SLC12A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the SLC12A transporter family. The encoded protein mediates the coupled movement of potassium and chloride ions across the plasma membrane. This gene is expressed ubiquitously. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell adhesion mediated by integrin (GO:0033627)4.76437503
2endodermal cell differentiation (GO:0035987)4.56611036
3protein heterotrimerization (GO:0070208)4.36430084
4apoptotic cell clearance (GO:0043277)4.29137266
5plasma membrane repair (GO:0001778)4.29010682
6chondrocyte proliferation (GO:0035988)4.20238554
7collagen fibril organization (GO:0030199)4.15923806
8basement membrane organization (GO:0071711)4.06348325
9wound healing, spreading of epidermal cells (GO:0035313)3.98496280
10skin morphogenesis (GO:0043589)3.91185052
11regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.87812902
12vascular endothelial growth factor signaling pathway (GO:0038084)3.71713552
13protein carboxylation (GO:0018214)3.71256639
14peptidyl-glutamic acid carboxylation (GO:0017187)3.71256639
15hemidesmosome assembly (GO:0031581)3.69214023
16regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.68240336
17cell-substrate junction assembly (GO:0007044)3.66770039
18epithelial cell-cell adhesion (GO:0090136)3.63881018
19negative regulation of fatty acid transport (GO:2000192)3.55740721
20planar cell polarity pathway involved in neural tube closure (GO:0090179)3.54575008
21neuron projection extension involved in neuron projection guidance (GO:1902284)3.54521132
22axon extension involved in axon guidance (GO:0048846)3.54521132
23negative regulation of fibrinolysis (GO:0051918)3.49568150
24cardiac myofibril assembly (GO:0055003)3.48276802
25low-density lipoprotein particle clearance (GO:0034383)3.38025230
26collagen metabolic process (GO:0032963)3.35356764
27regulation of hippo signaling (GO:0035330)3.29014200
28regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.26208915
29regulation of plasminogen activation (GO:0010755)3.25799760
30sarcomere organization (GO:0045214)3.25785042
31collagen catabolic process (GO:0030574)3.25043785
32positive regulation of endothelial cell apoptotic process (GO:2000353)3.24122266
33COPI coating of Golgi vesicle (GO:0048205)3.23697745
34Golgi transport vesicle coating (GO:0048200)3.23697745
35regulation of apoptotic cell clearance (GO:2000425)3.22911805
36apoptotic process involved in morphogenesis (GO:0060561)3.22541770
37atrioventricular valve morphogenesis (GO:0003181)3.19449723
38positive regulation of p38MAPK cascade (GO:1900745)3.15883782
39adherens junction assembly (GO:0034333)3.15394004
40wound healing, spreading of cells (GO:0044319)3.13801532
41extracellular matrix disassembly (GO:0022617)3.13768665
42multicellular organismal macromolecule metabolic process (GO:0044259)3.12105967
43positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.11855331
44regulation of tight junction assembly (GO:2000810)3.11832277
45protein retention in ER lumen (GO:0006621)3.10582917
46mannose metabolic process (GO:0006013)3.08750204
47regulation of extracellular matrix disassembly (GO:0010715)3.08327200
48renal filtration (GO:0097205)3.07914196
49glomerular basement membrane development (GO:0032836)3.07296579
50cell migration involved in sprouting angiogenesis (GO:0002042)3.05493227
51maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.04815261
52desmosome organization (GO:0002934)3.04306479
53retina vasculature morphogenesis in camera-type eye (GO:0061299)3.04151076
54stress fiber assembly (GO:0043149)3.03624297
55cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.01236062
56endothelial cell morphogenesis (GO:0001886)2.96987170
57branching involved in salivary gland morphogenesis (GO:0060445)2.96404344
58multicellular organismal catabolic process (GO:0044243)2.95782924
59multicellular organismal metabolic process (GO:0044236)2.94134598
60hippo signaling (GO:0035329)2.90009783
61positive regulation of osteoblast proliferation (GO:0033690)2.89587370
62extracellular matrix assembly (GO:0085029)2.87441353
63insulin-like growth factor receptor signaling pathway (GO:0048009)2.87203994
64focal adhesion assembly (GO:0048041)2.86008580
65cell-substrate adherens junction assembly (GO:0007045)2.86008580
66pinocytosis (GO:0006907)2.84747023
67regulation of p38MAPK cascade (GO:1900744)2.83682004
68positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.83580131
69substrate adhesion-dependent cell spreading (GO:0034446)2.83129995
70myofibril assembly (GO:0030239)2.83044597
71regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.81335505
72venous blood vessel morphogenesis (GO:0048845)2.81282215
73regulation of cholesterol homeostasis (GO:2000188)2.81181416
74regulation of SMAD protein import into nucleus (GO:0060390)2.80571004
75barbed-end actin filament capping (GO:0051016)2.80517031
76bone trabecula formation (GO:0060346)2.79418066
77regulation of membrane protein ectodomain proteolysis (GO:0051043)2.78194471
78regulation of fibrinolysis (GO:0051917)2.74238736
79response to fluid shear stress (GO:0034405)2.73137388
80cellular response to interferon-alpha (GO:0035457)2.72452329
81blood vessel endothelial cell migration (GO:0043534)2.69924919
82polarized epithelial cell differentiation (GO:0030859)2.69014306
83muscle filament sliding (GO:0030049)2.67561420
84actin-myosin filament sliding (GO:0033275)2.67561420
85protein hydroxylation (GO:0018126)2.66996883
86glomerular filtration (GO:0003094)2.64960225
87positive regulation of blood vessel endothelial cell migration (GO:0043536)2.63696233
88protein localization to endosome (GO:0036010)2.63191334
89glomerular visceral epithelial cell development (GO:0072015)2.63013679
90regulation of cholesterol storage (GO:0010885)2.61595338
91response to laminar fluid shear stress (GO:0034616)2.61335450
92peptidyl-proline hydroxylation (GO:0019511)2.60516221
93surfactant homeostasis (GO:0043129)2.60006071
94vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.57787422
95dermatan sulfate biosynthetic process (GO:0030208)2.56904495
96positive regulation of SMAD protein import into nucleus (GO:0060391)2.56599873
97adhesion of symbiont to host cell (GO:0044650)2.56588423
98virion attachment to host cell (GO:0019062)2.56588423
99negative regulation of smooth muscle cell migration (GO:0014912)2.55054399
100negative regulation of chondrocyte differentiation (GO:0032331)2.54872183
101cell migration involved in heart development (GO:0060973)2.53912573
102regulation of integrin activation (GO:0033623)2.52959691
103cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.52545687
104fibroblast migration (GO:0010761)2.51360339
105actomyosin structure organization (GO:0031032)2.50626161
106endothelial cell chemotaxis (GO:0035767)2.50088267
107endocardial cushion development (GO:0003197)2.49405354
108endocytic recycling (GO:0032456)2.48936394
109paraxial mesoderm development (GO:0048339)2.48730812
110extracellular fibril organization (GO:0043206)2.48716061
111adhesion of symbiont to host (GO:0044406)2.48631763
112negative regulation of heart growth (GO:0061117)2.48154350
113negative regulation of cardiac muscle tissue growth (GO:0055022)2.48154350
114substrate-dependent cell migration (GO:0006929)2.47374738
115keratan sulfate catabolic process (GO:0042340)2.47300191
116regulation of integrin-mediated signaling pathway (GO:2001044)2.46859734
117apoptotic process involved in development (GO:1902742)2.46668988
118positive regulation of epithelial to mesenchymal transition (GO:0010718)2.45157661
119regulation of extracellular matrix organization (GO:1903053)2.45108524
120extracellular structure organization (GO:0043062)2.44625241
121regulation of early endosome to late endosome transport (GO:2000641)2.44254378
122cytoskeletal anchoring at plasma membrane (GO:0007016)2.43220609
123positive regulation of receptor recycling (GO:0001921)2.43143836
124actin filament depolymerization (GO:0030042)2.42668223
125dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.42316432
126cell proliferation involved in metanephros development (GO:0072203)2.42066284
127semaphorin-plexin signaling pathway (GO:0071526)2.41741199
128Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.41570197
129tooth mineralization (GO:0034505)2.41038676
130positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.40631704
131cellular response to vitamin (GO:0071295)2.39540401
132retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.39417055
133embryonic process involved in female pregnancy (GO:0060136)2.38568568
134negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.37798707
135positive regulation of extracellular matrix organization (GO:1903055)2.36674937
136positive regulation of fatty acid beta-oxidation (GO:0032000)2.36669494
137type B pancreatic cell proliferation (GO:0044342)2.36171896
138extracellular matrix organization (GO:0030198)2.35636868
139hypotonic response (GO:0006971)2.34126274
140regulation of cholesterol biosynthetic process (GO:0045540)2.30569370
141kidney mesenchyme development (GO:0072074)2.30100338
142hyaluronan catabolic process (GO:0030214)2.29912155
143regulation of glucose import in response to insulin stimulus (GO:2001273)2.29241241
144regulation of establishment of planar polarity (GO:0090175)2.29217132
145protein targeting to plasma membrane (GO:0072661)2.28577361
146embryo implantation (GO:0007566)2.27384019

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.98264841
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.28296432
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.20258017
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.77062577
5CLOCK_20551151_ChIP-Seq_293T_Human3.31405896
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.18966571
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.66508855
8RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.57482631
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.54530307
10* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.52988265
11ELK3_25401928_ChIP-Seq_HUVEC_Human2.30323414
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.26845060
13HIF1A_21447827_ChIP-Seq_MCF-7_Human2.23030676
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13885446
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.07536659
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.02451215
17CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.97428057
18* ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.86078230
19KDM2B_26808549_Chip-Seq_SUP-B15_Human1.79556586
20ZNF263_19887448_ChIP-Seq_K562_Human1.77412373
21* TBX20_22328084_ChIP-Seq_HEART_Mouse1.73160639
22* TBX20_22080862_ChIP-Seq_HEART_Mouse1.73160639
23KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.73097477
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.72687117
25EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.71924532
26* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.71745503
27ATF3_27146783_Chip-Seq_COLON_Human1.69850562
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.66611050
29* RACK7_27058665_Chip-Seq_MCF-7_Human1.65643464
30PPAR_26484153_Chip-Seq_NCI-H1993_Human1.62450650
31EP300_21415370_ChIP-Seq_HL-1_Mouse1.61828603
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.61122827
33FOXO3_23340844_ChIP-Seq_DLD1_Human1.60090464
34SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.58714361
35SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.58695743
36SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.56247167
37SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.56247167
38CJUN_26792858_Chip-Seq_BT549_Human1.55046306
39KDM2B_26808549_Chip-Seq_DND41_Human1.52412269
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.52237233
41NFIB_24661679_ChIP-Seq_LUNG_Mouse1.50655403
42* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.49052440
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.48018017
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.47697190
45* LXR_22292898_ChIP-Seq_THP-1_Human1.46495795
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.45804971
47PPARA_22158963_ChIP-Seq_LIVER_Mouse1.45421573
48ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.44918313
49STAT3_1855785_ChIP-Seq_MESCs_Mouse1.44637105
50SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.43459524
51* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.40407705
52BRD4_25478319_ChIP-Seq_HGPS_Human1.40180201
53ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.40073808
54* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39678570
55UBF1/2_26484160_Chip-Seq_HMECs_Human1.38696777
56SOX9_24532713_ChIP-Seq_HFSC_Mouse1.37560265
57SALL4_18804426_ChIP-ChIP_XEN_Mouse1.36723320
58KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.36351490
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34585636
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.33523574
61UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32572715
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32226454
63RXR_22158963_ChIP-Seq_LIVER_Mouse1.32043078
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.31688645
65NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.30802742
66* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30744983
67LXR_22158963_ChIP-Seq_LIVER_Mouse1.30708856
68* TP53_22127205_ChIP-Seq_IMR90_Human1.29326756
69NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.25681219
70ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25574633
71JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24708330
72ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.24669721
73CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23058502
74* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22609116
75FOXA2_19822575_ChIP-Seq_HepG2_Human1.21358917
76* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19514790
77* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18449818
78SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18005419
79SMC3_22415368_ChIP-Seq_MEFs_Mouse1.17376043
80GATA2_21666600_ChIP-Seq_HMVEC_Human1.17124665
81* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.16964334
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16314419
83SMC1_22415368_ChIP-Seq_MEFs_Mouse1.16251210
84ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.15583393
85CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15537128
86SMC4_20622854_ChIP-Seq_HELA_Human1.13915693
87TCF7_22412390_ChIP-Seq_EML_Mouse1.12596128
88WT1_19549856_ChIP-ChIP_CCG9911_Human1.11698260
89CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11309349
90KDM2B_26808549_Chip-Seq_K562_Human1.11132090
91STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10718530
92FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.09360994
93FOXM1_23109430_ChIP-Seq_U2OS_Human1.09248186
94TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09111475
95* SA1_27219007_Chip-Seq_ERYTHROID_Human1.08864546
96* TP53_23651856_ChIP-Seq_MEFs_Mouse1.08462502
97JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08078664
98VDR_21846776_ChIP-Seq_THP-1_Human1.07966999
99ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07425706
100TET1_21451524_ChIP-Seq_MESCs_Mouse1.05582865
101MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.05577447
102SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05287323
103BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05201295
104KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04944754
105MYC_22102868_ChIP-Seq_BL_Human1.04612100
106CREB1_26743006_Chip-Seq_LNCaP_Human1.04391842
107CTCF_27219007_Chip-Seq_Bcells_Human1.03200038
108NCOR1_26117541_ChIP-Seq_K562_Human1.02836346
109KDM2B_26808549_Chip-Seq_JURKAT_Human1.02047222
110DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01731871
111* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01720488
112P68_20966046_ChIP-Seq_HELA_Human1.01054133
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00216949
114FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99788470
115TET1_21490601_ChIP-Seq_MESCs_Mouse0.99298154
116DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97596499
117ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97328614
118TP53_20018659_ChIP-ChIP_R1E_Mouse0.97207020
119DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94753732
120* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94484439
121* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94074455
122TP63_22573176_ChIP-Seq_HFKS_Human0.93659545
123RUNX1_27514584_Chip-Seq_MCF-7_Human0.93630539
124AR_21909140_ChIP-Seq_LNCAP_Human0.91920287
125SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88601726

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.99228971
2MP0003705_abnormal_hypodermis_morpholog4.09534272
3MP0005275_abnormal_skin_tensile3.64931116
4MP0003279_aneurysm3.05780458
5MP0004272_abnormal_basement_membrane2.95529418
6MP0001958_emphysema2.72412526
7MP0003566_abnormal_cell_adhesion2.68278219
8MP0005623_abnormal_meninges_morphology2.63522066
9MP0005503_abnormal_tendon_morphology2.62344071
10MP0004084_abnormal_cardiac_muscle2.27723562
11MP0010352_gastrointestinal_tract_polyps2.17635457
12MP0005409_darkened_coat_color2.05960715
13MP0000751_myopathy1.97750205
14MP0003091_abnormal_cell_migration1.92406884
15MP0005023_abnormal_wound_healing1.91870936
16MP0009384_cardiac_valve_regurgitation1.88434406
17MP0000750_abnormal_muscle_regeneration1.83031207
18MP0000733_abnormal_muscle_development1.77591138
19MP0010030_abnormal_orbit_morphology1.70573404
20MP0005257_abnormal_intraocular_pressure1.65940399
21MP0002060_abnormal_skin_morphology1.60243166
22MP0006054_spinal_hemorrhage1.57474802
23MP0005076_abnormal_cell_differentiation1.55744083
24MP0004087_abnormal_muscle_fiber1.53718934
25MP0005451_abnormal_body_composition1.46741152
26MP0000767_abnormal_smooth_muscle1.44004540
27MP0005508_abnormal_skeleton_morphology1.43376369
28MP0005330_cardiomyopathy1.39326290
29MP0000749_muscle_degeneration1.38868676
30MP0010630_abnormal_cardiac_muscle1.37150308
31MP0002837_dystrophic_cardiac_calcinosis1.34635507
32MP0004185_abnormal_adipocyte_glucose1.33984331
33MP0001661_extended_life_span1.33713769
34MP0001348_abnormal_lacrimal_gland1.31553419
35MP0003300_gastrointestinal_ulcer1.30090942
36MP0002295_abnormal_pulmonary_circulatio1.29992619
37MP0009278_abnormal_bone_marrow1.26540645
38MP0003950_abnormal_plasma_membrane1.26499660
39MP0010368_abnormal_lymphatic_system1.25435065
40MP0009840_abnormal_foam_cell1.24485275
41MP0005666_abnormal_adipose_tissue1.24115972
42MP0008775_abnormal_heart_ventricle1.23169426
43MP0006138_congestive_heart_failure1.21890618
44MP0002877_abnormal_melanocyte_morpholog1.21870459
45MP0000343_altered_response_to1.19763110
46MP0005360_urolithiasis1.19347328
47MP0003828_pulmonary_edema1.17700635
48MP0004036_abnormal_muscle_relaxation1.16220563
49MP0002108_abnormal_muscle_morphology1.13069347
50MP0000762_abnormal_tongue_morphology1.12999771
51MP0003303_peritoneal_inflammation1.12058210
52MP0003191_abnormal_cellular_cholesterol1.11447080
53MP0001243_abnormal_dermal_layer1.11390612
54MP0005670_abnormal_white_adipose1.11191416
55MP0001544_abnormal_cardiovascular_syste1.11005402
56MP0005385_cardiovascular_system_phenoty1.11005402
57MP0002896_abnormal_bone_mineralization1.09964324
58MP0003045_fibrosis1.07217552
59MP0004130_abnormal_muscle_cell1.06929129
60MP0005375_adipose_tissue_phenotype1.06545547
61MP0002128_abnormal_blood_circulation1.05988304
62MP0002972_abnormal_cardiac_muscle1.05404838
63MP0003448_altered_tumor_morphology1.04327468
64MP0001915_intracranial_hemorrhage1.03820698
65MP0003172_abnormal_lysosome_physiology1.02966685
66MP0001542_abnormal_bone_strength1.01398480
67MP0002269_muscular_atrophy1.01164411
68MP0008260_abnormal_autophagy1.00372456
69MP0001299_abnormal_eye_distance/1.00047250
70MP0003941_abnormal_skin_development0.99601862
71MP0003453_abnormal_keratinocyte_physiol0.98302947
72MP0000678_abnormal_parathyroid_gland0.97756991
73MP0000428_abnormal_craniofacial_morphol0.97750996
74MP0009053_abnormal_anal_canal0.96719223
75MP0000759_abnormal_skeletal_muscle0.95890412
76MP0002168_other_aberrant_phenotype0.95224026
77MP0002998_abnormal_bone_remodeling0.94874822
78MP0005390_skeleton_phenotype0.94640981
79MP0004858_abnormal_nervous_system0.94218622
80MP0004233_abnormal_muscle_weight0.92793340
81MP0003329_amyloid_beta_deposits0.92761992
82MP0004510_myositis0.92614538
83MP0001614_abnormal_blood_vessel0.92497329
84MP0002933_joint_inflammation0.92463930
85MP0005595_abnormal_vascular_smooth0.92223926
86MP0001849_ear_inflammation0.91375771
87MP0000747_muscle_weakness0.91056139
88MP0002254_reproductive_system_inflammat0.90888417
89MP0004215_abnormal_myocardial_fiber0.90861487
90MP0001533_abnormal_skeleton_physiology0.90093390
91MP0003942_abnormal_urinary_system0.89737694
92MP0002925_abnormal_cardiovascular_devel0.89374725
93MP0000003_abnormal_adipose_tissue0.87686008
94MP0003115_abnormal_respiratory_system0.87567941
95MP0005058_abnormal_lysosome_morphology0.87312688
96MP0003283_abnormal_digestive_organ0.85988588
97MP0003385_abnormal_body_wall0.85775025
98MP0001879_abnormal_lymphatic_vessel0.84483782
99MP0000579_abnormal_nail_morphology0.83279305
100MP0002106_abnormal_muscle_physiology0.82458537
101MP0000858_altered_metastatic_potential0.81562437
102MP0010307_abnormal_tumor_latency0.81041950
103MP0009780_abnormal_chondrocyte_physiolo0.80647692
104MP0005369_muscle_phenotype0.80646654
105MP0000266_abnormal_heart_morphology0.80298937
106MP0005620_abnormal_muscle_contractility0.80204870
107MP0002249_abnormal_larynx_morphology0.79860826
108MP0005164_abnormal_response_to0.79604361
109MP0002089_abnormal_postnatal_growth/wei0.79424544
110MP0009250_abnormal_appendicular_skeleto0.79188433
111MP0000467_abnormal_esophagus_morphology0.78529612
112MP0000163_abnormal_cartilage_morphology0.78056123
113MP0002115_abnormal_skeleton_extremities0.77803053
114MP0005165_increased_susceptibility_to0.76578750
115MP0000013_abnormal_adipose_tissue0.76071078
116MP0000534_abnormal_ureter_morphology0.74903570
117MP0004134_abnormal_chest_morphology0.74352449
118MP0005501_abnormal_skin_physiology0.65921347
119MP0000249_abnormal_blood_vessel0.64783818
120MP0001175_abnormal_lung_morphology0.62207778
121MP0002113_abnormal_skeleton_development0.60718290

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.18057772
2Premature rupture of membranes (HP:0001788)6.16781592
3Cerebral aneurysm (HP:0004944)4.16963941
4Shallow orbits (HP:0000586)4.16326665
5Ankle contracture (HP:0006466)4.06482367
6Increased connective tissue (HP:0009025)3.99013648
7Atrophic scars (HP:0001075)3.88643530
8Peritonitis (HP:0002586)3.83257304
9Aortic dissection (HP:0002647)3.67792440
10Broad metatarsal (HP:0001783)3.62931563
11Neonatal short-limb short stature (HP:0008921)3.23529565
12Aortic aneurysm (HP:0004942)3.13401575
13Cervical subluxation (HP:0003308)3.12689985
14Deep venous thrombosis (HP:0002625)3.12302052
15Muscle fiber splitting (HP:0003555)3.11775689
16Dilatation of the ascending aorta (HP:0005111)3.10375563
17Type 1 muscle fiber predominance (HP:0003803)3.09841530
18Fragile skin (HP:0001030)3.09359876
19Bladder diverticulum (HP:0000015)2.99300183
20Soft skin (HP:0000977)2.94494174
21Genu recurvatum (HP:0002816)2.85549848
22Mitral valve prolapse (HP:0001634)2.84576226
23Right ventricular cardiomyopathy (HP:0011663)2.81852685
24Upper limb amyotrophy (HP:0009129)2.78608061
25Distal upper limb amyotrophy (HP:0007149)2.78608061
26Spinal rigidity (HP:0003306)2.73321918
27Difficulty climbing stairs (HP:0003551)2.71416003
28Blue sclerae (HP:0000592)2.67885115
29Hyporeflexia of lower limbs (HP:0002600)2.67173700
30Aneurysm (HP:0002617)2.64017093
31Ulnar bowing (HP:0003031)2.57745418
32Abnormality of dentin (HP:0010299)2.56997519
33Wormian bones (HP:0002645)2.54504709
34Vertebral compression fractures (HP:0002953)2.52196190
35Ventricular tachycardia (HP:0004756)2.49179582
36Osteolytic defects of the phalanges of the hand (HP:0009771)2.46283569
37Osteolytic defects of the hand bones (HP:0009699)2.46283569
38Mitral stenosis (HP:0001718)2.40952855
39Increased variability in muscle fiber diameter (HP:0003557)2.36629189
40Mildly elevated creatine phosphokinase (HP:0008180)2.36104930
41Scapular winging (HP:0003691)2.35281418
42Hand muscle atrophy (HP:0009130)2.30074021
43Broad face (HP:0000283)2.27384065
44Hemorrhage of the eye (HP:0011885)2.24804960
45Wrist flexion contracture (HP:0001239)2.24360915
46Biconcave vertebral bodies (HP:0004586)2.23173775
47Follicular hyperkeratosis (HP:0007502)2.21442546
48Radial bowing (HP:0002986)2.17701459
49Sudden death (HP:0001699)2.17695179
50Hyperacusis (HP:0010780)2.16370712
51Short nail (HP:0001799)2.15528878
52Camptodactyly of toe (HP:0001836)2.14302778
53Abnormality of the acetabulum (HP:0003170)2.14221457
54Abnormality of skeletal muscle fiber size (HP:0012084)2.12631117
55Hypoplastic ischia (HP:0003175)2.12439586
56Exercise-induced muscle cramps (HP:0003710)2.11719380
57Elbow flexion contracture (HP:0002987)2.10431447
58Bowing of the arm (HP:0006488)2.09529579
59Bowed forearm bones (HP:0003956)2.09529579
60Lipoatrophy (HP:0100578)2.07768420
61Joint stiffness (HP:0001387)2.07465799
62Hyperextensible skin (HP:0000974)2.06945629
63Distal lower limb amyotrophy (HP:0008944)2.05254294
64Difficulty running (HP:0009046)2.04386977
65Ectopia lentis (HP:0001083)2.03849888
66Abnormality of the peritoneum (HP:0002585)2.02102606
67Asymmetric septal hypertrophy (HP:0001670)2.00400282
68Distal lower limb muscle weakness (HP:0009053)1.99424857
69Slender build (HP:0001533)1.98867956
70Natal tooth (HP:0000695)1.98729258
71Abnormality of carpal bone ossification (HP:0006257)1.96564666
72Abnormal ossification of hand bones (HP:0005921)1.95928047
73Flat acetabular roof (HP:0003180)1.95880353
74Vascular tortuosity (HP:0004948)1.95674883
75Aortic regurgitation (HP:0001659)1.94856451
76Cardiovascular calcification (HP:0011915)1.94628762
77Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.94411968
78Spondylolisthesis (HP:0003302)1.94242436
79Deviation of the hallux (HP:0010051)1.94242057
80Metaphyseal cupping (HP:0003021)1.94039554
81Abnormal delivery (HP:0001787)1.94030479
82Bowel diverticulosis (HP:0005222)1.92274712
83Abnormality of the calf musculature (HP:0001430)1.91768876
84Coxa vara (HP:0002812)1.91337832
85Coronal craniosynostosis (HP:0004440)1.91276102
86Generalized amyotrophy (HP:0003700)1.90820969
87Hallux valgus (HP:0001822)1.90037638
88Abnormality of complement system (HP:0005339)1.89694897
89Achilles tendon contracture (HP:0001771)1.89632915
90Lymphangioma (HP:0100764)1.89499685
91Myocardial infarction (HP:0001658)1.86639362
92Tibial bowing (HP:0002982)1.85472713
93Obstructive sleep apnea (HP:0002870)1.85424179
94Overgrowth (HP:0001548)1.85398665
95Round ear (HP:0100830)1.84763632
96Joint hemorrhage (HP:0005261)1.83908148
97Abnormality of the ischium (HP:0003174)1.83520271
98Joint laxity (HP:0001388)1.82876530
99Wide anterior fontanel (HP:0000260)1.82483967
100Infantile muscular hypotonia (HP:0008947)1.81952995
101Dislocated radial head (HP:0003083)1.81912360
102Knee flexion contracture (HP:0006380)1.81346740
103Atrial fibrillation (HP:0005110)1.80879248
104Nonimmune hydrops fetalis (HP:0001790)1.80104924
105Platyspondyly (HP:0000926)1.80004769
106Advanced eruption of teeth (HP:0006288)1.79490446
107Turricephaly (HP:0000262)1.78816660
108Disproportionate tall stature (HP:0001519)1.78679176
109Hip contracture (HP:0003273)1.77411291
110Osteoarthritis (HP:0002758)1.77037244
111Renal duplication (HP:0000075)1.76920232
112Ulnar deviation of the wrist (HP:0003049)1.76721349
113Mesangial abnormality (HP:0001966)1.76663323
114Thin ribs (HP:0000883)1.75781183
115Increased density of long bones (HP:0006392)1.75302762
116Premature skin wrinkling (HP:0100678)1.74327014
117Mitral regurgitation (HP:0001653)1.73295049
118Arterial tortuosity (HP:0005116)1.73117627
119Abnormality of the Achilles tendon (HP:0005109)1.72555607
120EMG: myopathic abnormalities (HP:0003458)1.72474951
121Complement deficiency (HP:0004431)1.72251617
122Alopecia of scalp (HP:0002293)1.71722299
123Abnormality of the calcaneus (HP:0008364)1.70333449
124Thin bony cortex (HP:0002753)1.70294782
125Abnormality of the radial head (HP:0003995)1.70074699
126Joint contractures involving the joints of the feet (HP:0100492)1.69687539
127Venous abnormality (HP:0002624)1.68746308
128Cupped ribs (HP:0000887)1.66487767
129Inguinal hernia (HP:0000023)1.64850577
130Back pain (HP:0003418)1.64412467
131Asymmetry of the thorax (HP:0001555)1.63361402
132Ovoid vertebral bodies (HP:0003300)1.63314301

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.88260829
2TRIB34.72813188
3PKN23.39632982
4DDR22.89948242
5ERN12.82975953
6PDGFRA2.67057106
7RIPK12.11058169
8SIK12.10651950
9EPHA22.02741476
10SMG12.02109956
11LATS11.95966046
12NTRK11.94587039
13PTK61.90263822
14EPHB11.84853841
15BMX1.84452395
16DMPK1.73604340
17PAK41.62325908
18PRPF4B1.60429910
19MAP3K101.56914820
20PAK21.54592345
21EEF2K1.53974757
22MST1R1.46523919
23LRRK21.44993798
24LATS21.44648261
25TGFBR21.40745561
26PTK21.38875811
27MAP3K31.36342231
28CDK121.34387227
29LMTK21.33361623
30MAP3K61.31249171
31PRKD21.29579441
32MTOR1.21231827
33TRPM71.18448645
34FGFR41.18392991
35EPHB21.18174206
36MET1.09870870
37RPS6KA41.09081344
38RPS6KA21.08180795
39STK31.04306547
40FER1.04264763
41PDGFRB1.04054000
42STK101.03805696
43MYLK1.02366661
44KDR1.01975311
45STK381.01964700
46FGFR11.00597214
47PAK30.99642351
48ROCK10.98978343
49ILK0.98530509
50MARK20.96766973
51FGFR30.96719770
52MAP2K30.95175195
53KSR20.93373027
54IRAK30.92554524
55TBK10.88860072
56WNK10.88263836
57CAMK1D0.87612003
58JAK10.87117934
59TESK10.86810721
60MAP3K130.85627035
61OBSCN0.84215369
62PTK2B0.84064880
63PDPK10.83568759
64NEK90.82599014
65CDK60.78765587
66ICK0.78124408
67AKT30.77387966
68TIE10.75994016
69EPHA30.74660393
70JAK30.71959343
71PRKD10.71336582
72DAPK30.71094103
73RPS6KL10.70854784
74RPS6KC10.70854784
75MOS0.70082674
76MAP3K80.68444111
77STK38L0.67669662
78NEK10.67438058
79PHKG20.66963054
80PHKG10.66963054
81ZAP700.65933234
82TYK20.65231830
83MAPK70.64529836
84MAPKAPK30.63519456
85CDC42BPA0.63414753
86ROCK20.63251287
87FLT30.62869017
88MAP2K10.62578721
89MAPK110.62317165
90LIMK10.61255142
91ALK0.60389350
92ARAF0.58612569
93PIM20.57983680
94MAPK150.56552032
95CSK0.55778132
96PRKCH0.54375366
97CHUK0.54038065
98ABL20.53247853
99MAP3K70.52621218
100NME20.52561070
101ERBB40.52370188
102DYRK1B0.51565381
103MAPK120.51476790
104TGFBR10.51165031
105PDK20.50894247
106GSK3A0.50838732
107RPS6KA60.50700360
108MAP3K10.50636913
109KIT0.49736707
110MELK0.47916145
111PIK3CA0.47785952
112PRKD30.47780429
113FGFR20.47477884
114PRKAA20.47283163
115TYRO30.47113908
116SGK30.45592268
117CDK40.44915472
118RET0.44591837
119PRKG20.44175644
120INSR0.43290958
121STK40.42733648
122TAOK20.41969333
123PDK40.41493552
124PDK30.41493552
125RPS6KB20.40942454
126SCYL20.39930509
127PIK3CG0.39115081
128ZAK0.37418753
129IKBKB0.36577909
130EGFR0.35818513
131WNK40.35796404
132PRKAA10.35611203
133PAK10.35321574
134MAP3K20.34728546
135HIPK20.34225516
136MAPK40.32028325
137SRC0.30948967

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.56300991
2Focal adhesion_Homo sapiens_hsa045102.71485209
3Other glycan degradation_Homo sapiens_hsa005112.66054333
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.48730651
5Dilated cardiomyopathy_Homo sapiens_hsa054142.44215148
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.20949912
7Small cell lung cancer_Homo sapiens_hsa052222.20527502
8Proteoglycans in cancer_Homo sapiens_hsa052052.10717015
9Amoebiasis_Homo sapiens_hsa051462.09412837
10AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.88488871
11Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.86572317
12Viral myocarditis_Homo sapiens_hsa054161.84234456
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.83173016
14Nitrogen metabolism_Homo sapiens_hsa009101.82992134
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.80825155
16Malaria_Homo sapiens_hsa051441.80712537
17Adherens junction_Homo sapiens_hsa045201.75935236
18Bladder cancer_Homo sapiens_hsa052191.74731947
19Protein digestion and absorption_Homo sapiens_hsa049741.53604399
20MicroRNAs in cancer_Homo sapiens_hsa052061.52834773
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.44324941
22Chronic myeloid leukemia_Homo sapiens_hsa052201.42515083
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.35834151
24Adipocytokine signaling pathway_Homo sapiens_hsa049201.34211944
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.32366107
26Hippo signaling pathway_Homo sapiens_hsa043901.30475203
27Toxoplasmosis_Homo sapiens_hsa051451.29623841
28Basal cell carcinoma_Homo sapiens_hsa052171.26151066
29Regulation of actin cytoskeleton_Homo sapiens_hsa048101.25174318
30PPAR signaling pathway_Homo sapiens_hsa033201.19857647
31Fatty acid degradation_Homo sapiens_hsa000711.19575084
32PI3K-Akt signaling pathway_Homo sapiens_hsa041511.17319942
33TGF-beta signaling pathway_Homo sapiens_hsa043501.14513806
34Notch signaling pathway_Homo sapiens_hsa043301.13619875
35Fatty acid metabolism_Homo sapiens_hsa012121.13406389
36Central carbon metabolism in cancer_Homo sapiens_hsa052301.13064871
37Insulin resistance_Homo sapiens_hsa049311.11515906
38Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05664206
39p53 signaling pathway_Homo sapiens_hsa041151.05600589
40Apoptosis_Homo sapiens_hsa042101.04885303
41Lysosome_Homo sapiens_hsa041421.02729737
42HIF-1 signaling pathway_Homo sapiens_hsa040661.00487634
43TNF signaling pathway_Homo sapiens_hsa046681.00021370
44Fatty acid biosynthesis_Homo sapiens_hsa000610.96889401
45Complement and coagulation cascades_Homo sapiens_hsa046100.96674883
46Fructose and mannose metabolism_Homo sapiens_hsa000510.95809041
47Tight junction_Homo sapiens_hsa045300.94551805
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94462904
49Leishmaniasis_Homo sapiens_hsa051400.94011453
50Carbon metabolism_Homo sapiens_hsa012000.92828701
51Pancreatic cancer_Homo sapiens_hsa052120.91422199
52Galactose metabolism_Homo sapiens_hsa000520.91419403
53Non-small cell lung cancer_Homo sapiens_hsa052230.90227198
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89455771
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88998200
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.88213867
57Hedgehog signaling pathway_Homo sapiens_hsa043400.88205284
58Shigellosis_Homo sapiens_hsa051310.88093988
59HTLV-I infection_Homo sapiens_hsa051660.87969684
60Lysine degradation_Homo sapiens_hsa003100.87381381
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86209499
62Pathways in cancer_Homo sapiens_hsa052000.83766865
63Melanoma_Homo sapiens_hsa052180.81156121
64GnRH signaling pathway_Homo sapiens_hsa049120.80730609
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.80437275
66Osteoclast differentiation_Homo sapiens_hsa043800.80428788
67Staphylococcus aureus infection_Homo sapiens_hsa051500.80069800
68mTOR signaling pathway_Homo sapiens_hsa041500.79804657
69Prostate cancer_Homo sapiens_hsa052150.79445034
70Legionellosis_Homo sapiens_hsa051340.77032413
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75442726
72Renal cell carcinoma_Homo sapiens_hsa052110.73659999
73Axon guidance_Homo sapiens_hsa043600.73166159
74Biosynthesis of amino acids_Homo sapiens_hsa012300.70186785
75Arginine biosynthesis_Homo sapiens_hsa002200.69790784
76Platelet activation_Homo sapiens_hsa046110.69772357
77Melanogenesis_Homo sapiens_hsa049160.69538357
78Prion diseases_Homo sapiens_hsa050200.69329684
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69243895
80Thyroid cancer_Homo sapiens_hsa052160.69060158
81ErbB signaling pathway_Homo sapiens_hsa040120.68699061
82Glioma_Homo sapiens_hsa052140.67791144
83Inositol phosphate metabolism_Homo sapiens_hsa005620.66992129
84AMPK signaling pathway_Homo sapiens_hsa041520.66831076
85Estrogen signaling pathway_Homo sapiens_hsa049150.66578349
86Salmonella infection_Homo sapiens_hsa051320.66242508
87Phenylalanine metabolism_Homo sapiens_hsa003600.66180578
88Rap1 signaling pathway_Homo sapiens_hsa040150.65209230
89Viral carcinogenesis_Homo sapiens_hsa052030.64538668
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64189860
91N-Glycan biosynthesis_Homo sapiens_hsa005100.64023250
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63737132
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61926332
94Pertussis_Homo sapiens_hsa051330.61395836
95Thyroid hormone synthesis_Homo sapiens_hsa049180.61201892
96Acute myeloid leukemia_Homo sapiens_hsa052210.60573807
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60399649
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59928015
99Dorso-ventral axis formation_Homo sapiens_hsa043200.59713584
100Phagosome_Homo sapiens_hsa041450.58231117
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58107293
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.58021162
103VEGF signaling pathway_Homo sapiens_hsa043700.57847474
104Choline metabolism in cancer_Homo sapiens_hsa052310.57800257
105Tuberculosis_Homo sapiens_hsa051520.56432115
106Glucagon signaling pathway_Homo sapiens_hsa049220.56370757
107Insulin signaling pathway_Homo sapiens_hsa049100.55880664
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55439758
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54846450
110Sulfur relay system_Homo sapiens_hsa041220.54769109
111Hepatitis B_Homo sapiens_hsa051610.54622387
112ABC transporters_Homo sapiens_hsa020100.54463917
113Sphingolipid metabolism_Homo sapiens_hsa006000.53030120
114Prolactin signaling pathway_Homo sapiens_hsa049170.52118054
115Pentose phosphate pathway_Homo sapiens_hsa000300.51710338
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50929815
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.49981569
118Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48871591
119Starch and sucrose metabolism_Homo sapiens_hsa005000.45197190
120Endometrial cancer_Homo sapiens_hsa052130.44480656
121NF-kappa B signaling pathway_Homo sapiens_hsa040640.43274994
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42286295
123Endocytosis_Homo sapiens_hsa041440.40935480
124Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40342698
125Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39981387
126Caffeine metabolism_Homo sapiens_hsa002320.39806534
127FoxO signaling pathway_Homo sapiens_hsa040680.39334472
128Bile secretion_Homo sapiens_hsa049760.37362641
129One carbon pool by folate_Homo sapiens_hsa006700.35649165
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.35047586
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.34438441

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