SLC12A6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.90796697
2B cell receptor signaling pathway (GO:0050853)4.66448713
3detection of molecule of bacterial origin (GO:0032490)4.56529708
4detection of other organism (GO:0098543)4.47956169
5positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.28392364
6negative regulation of interleukin-12 production (GO:0032695)4.24194871
7response to peptidoglycan (GO:0032494)4.21680709
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.17383586
9negative regulation of cell killing (GO:0031342)4.17383586
10negative regulation of lymphocyte mediated immunity (GO:0002707)4.14092325
11detection of external biotic stimulus (GO:0098581)4.11388495
12detection of bacterium (GO:0016045)4.05481231
13negative regulation of T cell mediated immunity (GO:0002710)4.04890413
14microglial cell activation (GO:0001774)4.02692438
15locomotory exploration behavior (GO:0035641)3.98324731
16leukocyte aggregation (GO:0070486)3.96517237
17response to host immune response (GO:0052572)3.84537259
18response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.84537259
19negative thymic T cell selection (GO:0045060)3.81299413
20negative T cell selection (GO:0043383)3.78149151
21positive regulation of B cell differentiation (GO:0045579)3.76047239
22regulation of B cell receptor signaling pathway (GO:0050855)3.65931692
23neutrophil mediated immunity (GO:0002446)3.65111878
24positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.64977300
25detection of biotic stimulus (GO:0009595)3.63078121
26macrophage activation (GO:0042116)3.62933021
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.61430417
28negative regulation of leukocyte mediated immunity (GO:0002704)3.59721894
29activated T cell proliferation (GO:0050798)3.58964926
30synaptic vesicle maturation (GO:0016188)3.58622748
31response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.57481266
32response to host (GO:0075136)3.57481266
33response to host defenses (GO:0052200)3.57481266
34regulation of ARF protein signal transduction (GO:0032012)3.52102411
35regulation of gamma-delta T cell differentiation (GO:0045586)3.50535898
36negative regulation of erythrocyte differentiation (GO:0045647)3.45043448
37negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.43014587
38regulation of short-term neuronal synaptic plasticity (GO:0048172)3.41183326
39regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.40417634
40response to muramyl dipeptide (GO:0032495)3.39569421
41positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.38815739
42respiratory burst (GO:0045730)3.36954484
43regulation of gamma-delta T cell activation (GO:0046643)3.35263875
44regulation of B cell differentiation (GO:0045577)3.34010377
45tolerance induction (GO:0002507)3.29511530
46regulation of synaptic vesicle exocytosis (GO:2000300)3.23108736
47immunoglobulin mediated immune response (GO:0016064)3.21539919
48regulation of mast cell activation (GO:0033003)3.21342107
49positive regulation of granulocyte differentiation (GO:0030854)3.21303619
50negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.18107640
51leukocyte migration involved in inflammatory response (GO:0002523)3.17756967
52negative regulation of T-helper cell differentiation (GO:0045623)3.17337134
53negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.17337134
54myeloid leukocyte mediated immunity (GO:0002444)3.13544077
55regulation of mast cell activation involved in immune response (GO:0033006)3.12052198
56regulation of tolerance induction (GO:0002643)3.11667334
57positive regulation of Rap GTPase activity (GO:0032854)3.11200088
58T cell migration (GO:0072678)3.10637455
59macrophage activation involved in immune response (GO:0002281)3.09442083
60production of molecular mediator involved in inflammatory response (GO:0002532)3.09158447
61histone H3-K4 trimethylation (GO:0080182)3.08074327
62synaptic vesicle exocytosis (GO:0016079)3.04555183
63defense response to protozoan (GO:0042832)3.02215581
64regulation of myeloid leukocyte mediated immunity (GO:0002886)3.01971800
65positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.00061021
66regulation of alpha-beta T cell proliferation (GO:0046640)2.99830407
67regulation of leukocyte degranulation (GO:0043300)2.97026082
68negative regulation of adaptive immune response (GO:0002820)2.96897499
69regulation of T cell tolerance induction (GO:0002664)2.93229071
70regulation of Rap GTPase activity (GO:0032317)2.92814754
71regulation of interferon-beta biosynthetic process (GO:0045357)2.92131198
72leukocyte degranulation (GO:0043299)2.91821445
73antigen processing and presentation via MHC class Ib (GO:0002475)2.90545287
74G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.89908492
75interferon-gamma production (GO:0032609)2.85856209
76cerebellar Purkinje cell differentiation (GO:0021702)2.84909156
77regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.84339646
78sodium ion export (GO:0071436)2.84089670
79negative regulation of interleukin-6 production (GO:0032715)2.83422772
80dendritic cell migration (GO:0036336)2.81151401
81regulation of regulatory T cell differentiation (GO:0045589)2.80208629
82regulation of T cell mediated cytotoxicity (GO:0001914)2.80158103
83positive regulation of interferon-alpha production (GO:0032727)2.79779687
84interferon-gamma-mediated signaling pathway (GO:0060333)2.79161039
85regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.78507481
86thymic T cell selection (GO:0045061)2.78410324
87positive regulation of tolerance induction (GO:0002645)2.76743460
88response to protozoan (GO:0001562)2.76661915
89modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.76647991
90positive regulation by organism of defense response of other organism involved in symbiotic interact2.76647991
91modulation by symbiont of host immune response (GO:0052553)2.76647991
92positive regulation by symbiont of host defense response (GO:0052509)2.76647991
93modulation by symbiont of host defense response (GO:0052031)2.76647991
94modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.76647991
95regulation of synaptic vesicle transport (GO:1902803)2.74248345
96regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.71682261
97positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.71190882
98positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.69256387
99cellular potassium ion homeostasis (GO:0030007)2.67288751
100regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.67160367
101synaptic vesicle docking involved in exocytosis (GO:0016081)2.64683256
102regulation of glutamate receptor signaling pathway (GO:1900449)2.63171634
103B cell proliferation (GO:0042100)2.61532075
104positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.61220333
105vocalization behavior (GO:0071625)2.59898359
106synaptic vesicle endocytosis (GO:0048488)2.58731651
107regulation of platelet aggregation (GO:0090330)2.58595272
108neutrophil activation (GO:0042119)2.55693107
109ionotropic glutamate receptor signaling pathway (GO:0035235)2.54915358
110mast cell degranulation (GO:0043303)2.53726292
111mast cell activation involved in immune response (GO:0002279)2.53726292
112retrograde transport, vesicle recycling within Golgi (GO:0000301)2.53547034
113exploration behavior (GO:0035640)2.53515435
114antigen processing and presentation of endogenous antigen (GO:0019883)2.52092561
115glutamate secretion (GO:0014047)2.50215114
116clathrin coat assembly (GO:0048268)2.50211312
117positive regulation of mast cell degranulation (GO:0043306)2.50035865
118positive regulation of mast cell activation involved in immune response (GO:0033008)2.50035865
119positive T cell selection (GO:0043368)2.46294381
120adaptation of signaling pathway (GO:0023058)2.45537090
121neutrophil activation involved in immune response (GO:0002283)2.44194700
122positive thymic T cell selection (GO:0045059)2.44150640
123neuronal action potential propagation (GO:0019227)2.43485803
124B cell homeostasis (GO:0001782)2.43237805
125response to interleukin-15 (GO:0070672)2.42762911
126phosphatidylinositol dephosphorylation (GO:0046856)2.42095632
127T cell selection (GO:0045058)2.40237625
128neurotransmitter secretion (GO:0007269)2.40141003
129myeloid cell activation involved in immune response (GO:0002275)2.40112916
130antigen receptor-mediated signaling pathway (GO:0050851)2.39716629
131Golgi to endosome transport (GO:0006895)2.39421144
132mast cell activation (GO:0045576)2.38679956
133negative regulation of synaptic transmission, GABAergic (GO:0032229)2.38183339
134activation of protein kinase A activity (GO:0034199)2.37979526
135germinal center formation (GO:0002467)2.37795381
136serine transport (GO:0032329)2.37619742
137positive regulation of mast cell activation (GO:0033005)2.36539534
138granulocyte activation (GO:0036230)2.36279039
139cytoplasmic mRNA processing body assembly (GO:0033962)2.36016021
140long-term synaptic potentiation (GO:0060291)2.33947557
141cellular response to interleukin-15 (GO:0071350)2.33351694
142peptidyl-threonine phosphorylation (GO:0018107)2.33340485
143negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.32301384
144membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.32107400
145protein localization to synapse (GO:0035418)2.31940345
146membrane depolarization during action potential (GO:0086010)2.31577850
147regulation of excitatory postsynaptic membrane potential (GO:0060079)2.30749144
148establishment of protein localization to Golgi (GO:0072600)2.30708936
149nerve growth factor signaling pathway (GO:0038180)2.30484498
150regulation of ARF GTPase activity (GO:0032312)2.29798559
151regulation of NFAT protein import into nucleus (GO:0051532)2.29161447
152negative regulation of phagocytosis (GO:0050765)2.27352806
153activation of JUN kinase activity (GO:0007257)2.26327279
154long-term memory (GO:0007616)2.25428488
155antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.24697991
156antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.24697991
157regulation of regulated secretory pathway (GO:1903305)2.22724308
158L-serine transport (GO:0015825)2.20796261
159regulation of mast cell degranulation (GO:0043304)2.20151044
160mature B cell differentiation (GO:0002335)2.19469948
161cellular extravasation (GO:0045123)2.18842362
162protein targeting to Golgi (GO:0000042)2.18707669
163positive regulation of membrane potential (GO:0045838)2.18626325

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.68377418
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.48495449
3EZH2_22144423_ChIP-Seq_EOC_Human3.37635336
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.10550191
5VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.68856799
6RUNX_20019798_ChIP-Seq_JUKART_Human2.53044433
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.48833388
8* SPI1_23547873_ChIP-Seq_NB4_Human2.33656182
9* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.32211729
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.23940635
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.19371161
12IKZF1_21737484_ChIP-ChIP_HCT116_Human2.09394135
13FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.05369968
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05206711
15DROSHA_22980978_ChIP-Seq_HELA_Human2.04126859
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.01676915
17SCL_19346495_ChIP-Seq_HPC-7_Human1.97694502
18MYC_22102868_ChIP-Seq_BL_Human1.92955272
19STAT4_19710469_ChIP-ChIP_TH1__Mouse1.92323992
20SPI1_23127762_ChIP-Seq_K562_Human1.91446064
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.88066775
22* IRF8_21731497_ChIP-ChIP_J774_Mouse1.86555576
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.85085416
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.74720415
25KDM2B_26808549_Chip-Seq_SUP-B15_Human1.73857688
26GBX2_23144817_ChIP-Seq_PC3_Human1.73570905
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.68058875
28TCF7_22412390_ChIP-Seq_EML_Mouse1.66260291
29VDR_21846776_ChIP-Seq_THP-1_Human1.65521385
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63520655
31KDM2B_26808549_Chip-Seq_DND41_Human1.55730159
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54020566
33* GATA3_26560356_Chip-Seq_TH2_Human1.53713486
34GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.50831905
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.49553273
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49364674
37NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.48575055
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.47453290
39* MYB_26560356_Chip-Seq_TH2_Human1.43823540
40GATA1_22025678_ChIP-Seq_K562_Human1.42290544
41MAF_26560356_Chip-Seq_TH2_Human1.41851410
42SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41767571
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40525643
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.39680639
45* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.39661105
46VDR_24763502_ChIP-Seq_THP-1_Human1.39593982
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.32643258
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32613189
49REST_21632747_ChIP-Seq_MESCs_Mouse1.31364712
50VDR_24787735_ChIP-Seq_THP-1_Human1.31075536
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30606982
52SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.27472716
53* UTX_26944678_Chip-Seq_JUKART_Human1.24229581
54* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23869786
55* MAF_26560356_Chip-Seq_TH1_Human1.23679651
56SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.22711257
57GATA2_21666600_ChIP-Seq_HMVEC_Human1.22628318
58MTF2_20144788_ChIP-Seq_MESCs_Mouse1.22425848
59* MYB_26560356_Chip-Seq_TH1_Human1.22269325
60MYB_21317192_ChIP-Seq_ERMYB_Mouse1.22259391
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.20704180
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20545621
63GATA1_19941827_ChIP-Seq_MEL_Mouse1.18640911
64IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18486562
65ARNT_22903824_ChIP-Seq_MCF-7_Human1.17806268
66NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17597858
67SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.16934056
68GATA3_27048872_Chip-Seq_THYMUS_Human1.16527264
69KDM2B_26808549_Chip-Seq_JURKAT_Human1.16281702
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15200831
71JARID2_20064375_ChIP-Seq_MESCs_Mouse1.15197555
72AHR_22903824_ChIP-Seq_MCF-7_Human1.14841485
73CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14027946
74* SMAD4_21799915_ChIP-Seq_A2780_Human1.13043423
75GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12167191
76TP53_16413492_ChIP-PET_HCT116_Human1.11636599
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11442435
78SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10887955
79STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10725624
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10011102
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09400435
82AR_21572438_ChIP-Seq_LNCaP_Human1.08627638
83TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08515749
84* KDM2B_26808549_Chip-Seq_K562_Human1.08220709
85BP1_19119308_ChIP-ChIP_Hs578T_Human1.07203395
86RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.05937557
87* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04993478
88MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04769207
89EZH2_18974828_ChIP-Seq_MESCs_Mouse1.04208801
90RNF2_18974828_ChIP-Seq_MESCs_Mouse1.04208801
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01972000
92CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01753354
93PU_27001747_Chip-Seq_BMDM_Mouse1.01522283
94DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00483206
95STAT3_23295773_ChIP-Seq_U87_Human1.00455569
96REST_18959480_ChIP-ChIP_MESCs_Mouse1.00015557
97VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98774346
98WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97963046
99CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97115360
100BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96905236
101RUNX1_22412390_ChIP-Seq_EML_Mouse0.96898406
102TCF4_23295773_ChIP-Seq_U87_Human0.96282612
103GATA1_19941826_ChIP-Seq_K562_Human0.96234005
104P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95992969
105CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95904718
106TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95402439
107PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94985130
108STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94951798
109SMRT_27268052_Chip-Seq_Bcells_Human0.94052573
110SOX2_21211035_ChIP-Seq_LN229_Gbm0.93880299
111ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.93792056
112PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93190771
113TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92679684
114AR_19668381_ChIP-Seq_PC3_Human0.92645323
115GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92086549
116CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91985868
117GATA1_19941827_ChIP-Seq_MEL86_Mouse0.91892242
118NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91811135
119TAF15_26573619_Chip-Seq_HEK293_Human0.91605588
120GATA2_19941826_ChIP-Seq_K562_Human0.91289701
121PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90193153
122RNF2_27304074_Chip-Seq_ESCs_Mouse0.89716622
123SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.89672989
124PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88160146
125NOTCH1_21737748_ChIP-Seq_TLL_Human0.84981648
126CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83491853
127STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.81886191
128FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.80257052
129PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79635862
130SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.79068939
131* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75307782
132KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.74804278
133SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.74598355
134SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.72904315
135FOXO3_23340844_ChIP-Seq_DLD1_Human0.72005892
136PU.1_20513432_ChIP-Seq_Bcells_Mouse0.67921744
137* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.66931404
138PRDM14_20953172_ChIP-Seq_ESCs_Human0.65054693
139GATA3_26560356_Chip-Seq_TH1_Human0.64893146
140TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.60656279
141* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.60529436

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.65012214
2MP0004859_abnormal_synaptic_plasticity3.98684638
3MP0000569_abnormal_digit_pigmentation3.81072947
4MP0001835_abnormal_antigen_presentation2.83009969
5MP0003303_peritoneal_inflammation2.66035338
6MP0001800_abnormal_humoral_immune2.52726003
7MP0001790_abnormal_immune_system2.49110405
8MP0005387_immune_system_phenotype2.49110405
9* MP0003635_abnormal_synaptic_transmissio2.35914839
10MP0003787_abnormal_imprinting2.33296955
11MP0002166_altered_tumor_susceptibility2.30325718
12MP0009046_muscle_twitch2.10245022
13MP0002452_abnormal_antigen_presenting2.09820450
14MP0006082_CNS_inflammation2.05612099
15MP0003183_abnormal_peptide_metabolism2.02845319
16MP0003828_pulmonary_edema1.99148703
17MP0005671_abnormal_response_to1.95792208
18MP0003300_gastrointestinal_ulcer1.94998877
19* MP0002064_seizures1.94354166
20MP0003172_abnormal_lysosome_physiology1.92316535
21MP0004510_myositis1.91414203
22MP0001533_abnormal_skeleton_physiology1.91076665
23* MP0009745_abnormal_behavioral_response1.90899510
24MP0003191_abnormal_cellular_cholesterol1.89212255
25MP0005000_abnormal_immune_tolerance1.88501504
26MP0002420_abnormal_adaptive_immunity1.88364657
27MP0001819_abnormal_immune_cell1.85364267
28MP0008569_lethality_at_weaning1.82588566
29MP0002723_abnormal_immune_serum1.81614816
30MP0008260_abnormal_autophagy1.78369349
31MP0002398_abnormal_bone_marrow1.78322051
32MP0003880_abnormal_central_pattern1.75615490
33MP0002006_tumorigenesis1.74850630
34* MP0002063_abnormal_learning/memory/cond1.73283637
35MP0001968_abnormal_touch/_nociception1.71271095
36MP0000685_abnormal_immune_system1.70191781
37MP0009278_abnormal_bone_marrow1.68524149
38MP0004381_abnormal_hair_follicle1.68167998
39MP0004270_analgesia1.58295043
40MP0000716_abnormal_immune_system1.56951845
41* MP0002572_abnormal_emotion/affect_behav1.56507196
42MP0000015_abnormal_ear_pigmentation1.55233981
43MP0005174_abnormal_tail_pigmentation1.54615090
44MP0004808_abnormal_hematopoietic_stem1.52312006
45MP0003656_abnormal_erythrocyte_physiolo1.49901608
46MP0002419_abnormal_innate_immunity1.49471987
47MP0005451_abnormal_body_composition1.48928547
48MP0004883_abnormal_blood_vessel1.48457093
49MP0001486_abnormal_startle_reflex1.46266125
50MP0000689_abnormal_spleen_morphology1.44165958
51MP0003045_fibrosis1.43411978
52MP0009333_abnormal_splenocyte_physiolog1.42277383
53MP0002132_abnormal_respiratory_system1.41756546
54MP0009764_decreased_sensitivity_to1.40951400
55MP0002909_abnormal_adrenal_gland1.39575671
56MP0005310_abnormal_salivary_gland1.37273679
57MP0002009_preneoplasia1.36665909
58MP0002822_catalepsy1.35772723
59MP0005464_abnormal_platelet_physiology1.34861597
60MP0001851_eye_inflammation1.33119977
61MP0002396_abnormal_hematopoietic_system1.32730563
62MP0008961_abnormal_basal_metabolism1.30264075
63MP0002272_abnormal_nervous_system1.30059043
64MP0002735_abnormal_chemical_nociception1.29880099
65MP0002998_abnormal_bone_remodeling1.29442106
66MP0001986_abnormal_taste_sensitivity1.27855253
67MP0008469_abnormal_protein_level1.26788805
68MP0002722_abnormal_immune_system1.26675257
69MP0005025_abnormal_response_to1.26543629
70MP0005423_abnormal_somatic_nervous1.26156006
71MP0001873_stomach_inflammation1.24009143
72* MP0002067_abnormal_sensory_capabilities1.20811106
73MP0003866_abnormal_defecation1.20458273
74MP0003879_abnormal_hair_cell1.19525620
75MP0008874_decreased_physiological_sensi1.18812062
76MP0003436_decreased_susceptibility_to1.18277153
77MP0000703_abnormal_thymus_morphology1.17844962
78MP0002429_abnormal_blood_cell1.17756981
79MP0005551_abnormal_eye_electrophysiolog1.17398111
80MP0005058_abnormal_lysosome_morphology1.16841758
81MP0001501_abnormal_sleep_pattern1.16637756
82MP0002736_abnormal_nociception_after1.15649063
83MP0005164_abnormal_response_to1.14256873
84MP0001545_abnormal_hematopoietic_system1.13593083
85MP0005397_hematopoietic_system_phenotyp1.13593083
86* MP0003633_abnormal_nervous_system1.11454422
87MP0003763_abnormal_thymus_physiology1.10670297
88MP0000465_gastrointestinal_hemorrhage1.09675581
89MP0004130_abnormal_muscle_cell1.08795704
90MP0000858_altered_metastatic_potential1.07783177
91MP0002277_abnormal_respiratory_mucosa1.07640371
92MP0009785_altered_susceptibility_to1.07262096
93MP0004947_skin_inflammation1.06423501
94MP0009780_abnormal_chondrocyte_physiolo1.05534259
95MP0004811_abnormal_neuron_physiology1.03241122
96MP0002148_abnormal_hypersensitivity_rea1.02947143
97MP0005075_abnormal_melanosome_morpholog1.02202654
98MP0002734_abnormal_mechanical_nocicepti1.00420838
99MP0001970_abnormal_pain_threshold0.98435029
100MP0005409_darkened_coat_color0.98403040
101MP0010234_abnormal_vibrissa_follicle0.97401262
102MP0001853_heart_inflammation0.96579060
103MP0010155_abnormal_intestine_physiology0.95700408
104MP0000604_amyloidosis0.95583189
105MP0008057_abnormal_DNA_replication0.95281622
106MP0004924_abnormal_behavior0.92290020
107MP0005386_behavior/neurological_phenoty0.92290020
108MP0001984_abnormal_olfaction0.89680760
109MP0003690_abnormal_glial_cell0.89085232
110MP0001879_abnormal_lymphatic_vessel0.87914147
111MP0002405_respiratory_system_inflammati0.87334436
112MP0001845_abnormal_inflammatory_respons0.86736274
113MP0002733_abnormal_thermal_nociception0.84896306
114MP0001440_abnormal_grooming_behavior0.84610475
115MP0008004_abnormal_stomach_pH0.81857331
116* MP0003631_nervous_system_phenotype0.81490495
117MP0002557_abnormal_social/conspecific_i0.80015229
118MP0003448_altered_tumor_morphology0.78678772
119MP0001663_abnormal_digestive_system0.77454731
120MP0000249_abnormal_blood_vessel0.76359137
121* MP0002229_neurodegeneration0.76233877
122MP0002928_abnormal_bile_duct0.75748052
123MP0002933_joint_inflammation0.75179587
124MP0002095_abnormal_skin_pigmentation0.74824309
125MP0003075_altered_response_to0.74761981
126MP0009763_increased_sensitivity_to0.74244198
127MP0003091_abnormal_cell_migration0.73449971
128MP0005645_abnormal_hypothalamus_physiol0.73311428
129MP0006054_spinal_hemorrhage0.73069749
130MP0004484_altered_response_of0.72462609
131MP0003221_abnormal_cardiomyocyte_apopto0.72268858
132MP0002138_abnormal_hepatobiliary_system0.72032374
133MP0005166_decreased_susceptibility_to0.71703318
134MP0005390_skeleton_phenotype0.69198677
135MP0009765_abnormal_xenobiotic_induced0.68567202
136MP0000371_diluted_coat_color0.60914310
137MP0005388_respiratory_system_phenotype0.60169907
138MP0002133_abnormal_respiratory_system0.60169907
139MP0009115_abnormal_fat_cell0.59831983
140MP0002332_abnormal_exercise_endurance0.59396921
141MP0000343_altered_response_to0.59352861
142MP0003795_abnormal_bone_structure0.58829983

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)5.32582482
2Orchitis (HP:0100796)5.14542049
3Optic neuritis (HP:0100653)5.13253477
4Retrobulbar optic neuritis (HP:0100654)5.13253477
5Agammaglobulinemia (HP:0004432)4.88052622
6Stomatitis (HP:0010280)4.62342150
7Abnormality of macrophages (HP:0004311)4.40183093
8Elevated erythrocyte sedimentation rate (HP:0003565)4.27054833
9Recurrent gram-negative bacterial infections (HP:0005420)4.18850882
10Gastrointestinal infarctions (HP:0005244)4.11288573
11Cellulitis (HP:0100658)3.93579066
12Keratoconjunctivitis sicca (HP:0001097)3.87383449
13Thyroiditis (HP:0100646)3.69688404
14Verrucae (HP:0200043)3.66961008
15Papilloma (HP:0012740)3.66961008
16Recurrent viral infections (HP:0004429)3.62769574
17Keratoconjunctivitis (HP:0001096)3.62650959
18Encephalitis (HP:0002383)3.60999442
19Abnormality of B cell number (HP:0010975)3.50565625
20B lymphocytopenia (HP:0010976)3.50565625
21Colitis (HP:0002583)3.47022508
22Panhypogammaglobulinemia (HP:0003139)3.40439351
23Chronic obstructive pulmonary disease (HP:0006510)3.38446395
24Obstructive lung disease (HP:0006536)3.38446395
25Abnormality of the fingertips (HP:0001211)3.37143607
26Gingivitis (HP:0000230)3.33582585
27Prolonged bleeding time (HP:0003010)3.29073281
28Focal motor seizures (HP:0011153)3.25310401
29Febrile seizures (HP:0002373)3.23541023
30Chest pain (HP:0100749)3.21182205
31Hemoptysis (HP:0002105)3.17454270
32Abnormality of T cells (HP:0002843)3.11527246
33Recurrent abscess formation (HP:0002722)3.11522043
34Pulmonary infiltrates (HP:0002113)3.09923337
35Increased IgE level (HP:0003212)3.07088270
36Leukocytosis (HP:0001974)3.06581490
37Recurrent fungal infections (HP:0002841)3.05910385
38Gingival bleeding (HP:0000225)3.05492293
39Urticaria (HP:0001025)3.05221329
40Arterial thrombosis (HP:0004420)3.01735700
41Inflammation of the large intestine (HP:0002037)2.97589061
42Pustule (HP:0200039)2.90440644
43Recurrent bronchitis (HP:0002837)2.89825305
44Gastrointestinal stroma tumor (HP:0100723)2.87921281
45Focal seizures (HP:0007359)2.86507206
46Meningitis (HP:0001287)2.85902915
47Gastrointestinal inflammation (HP:0004386)2.83438490
48Macroorchidism (HP:0000053)2.83325815
49Epistaxis (HP:0000421)2.83172115
50Papilledema (HP:0001085)2.81741423
51Recurrent bacterial skin infections (HP:0005406)2.81277894
52Pulmonary embolism (HP:0002204)2.72678610
53Visual hallucinations (HP:0002367)2.70377934
54Episodic fever (HP:0001954)2.66473874
55Peritonitis (HP:0002586)2.65922501
56Progressive cerebellar ataxia (HP:0002073)2.65486111
57Abnormal delayed hypersensitivity skin test (HP:0002963)2.64447264
58Vertebral arch anomaly (HP:0008438)2.64193530
59Granulocytopenia (HP:0001913)2.60066936
60Hypochromic microcytic anemia (HP:0004840)2.57376098
61Hematochezia (HP:0002573)2.55882014
62Chronic mucocutaneous candidiasis (HP:0002728)2.53835625
63Recurrent cutaneous fungal infections (HP:0011370)2.53835625
64Abnormality of T cell physiology (HP:0011840)2.50185433
65Osteomyelitis (HP:0002754)2.49123345
66Atonic seizures (HP:0010819)2.49036291
67Hypochromic anemia (HP:0001931)2.46665441
68Gangrene (HP:0100758)2.43398305
69Anorexia (HP:0002039)2.43006322
70Epileptic encephalopathy (HP:0200134)2.42048268
71Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.41921533
72Recurrent sinusitis (HP:0011108)2.41799665
73T lymphocytopenia (HP:0005403)2.41214389
74Postural instability (HP:0002172)2.40810834
75Viral hepatitis (HP:0006562)2.39511711
76Truncal ataxia (HP:0002078)2.33924027
77Autoimmune hemolytic anemia (HP:0001890)2.33813690
78Abnormality of the pleura (HP:0002103)2.29902341
79Genetic anticipation (HP:0003743)2.29612618
80Supranuclear gaze palsy (HP:0000605)2.29142625
81Inappropriate behavior (HP:0000719)2.25912400
82Widely spaced teeth (HP:0000687)2.24035272
83Slow saccadic eye movements (HP:0000514)2.23965346
84Abnormality of T cell number (HP:0011839)2.23303338
85Absent frontal sinuses (HP:0002688)2.23175876
86Myokymia (HP:0002411)2.22175359
87Eczematoid dermatitis (HP:0000976)2.22108706
88Sepsis (HP:0100806)2.21993859
89Abnormality of the endocardium (HP:0004306)2.18857182
90Action tremor (HP:0002345)2.18191828
91Chronic sinusitis (HP:0011109)2.17780281
92Lymphopenia (HP:0001888)2.17641726
93Gaze-evoked nystagmus (HP:0000640)2.17275981
94Subacute progressive viral hepatitis (HP:0006572)2.17047750
95Abnormality of eosinophils (HP:0001879)2.16709187
96IgM deficiency (HP:0002850)2.16378546
97Abnormality of the peritoneum (HP:0002585)2.15511816
98Hemiplegia (HP:0002301)2.14169594
99Microcytic anemia (HP:0001935)2.12360010
100Dysmetric saccades (HP:0000641)2.09535775
101Congenital stationary night blindness (HP:0007642)2.09285925
102Vasculitis (HP:0002633)2.07661487
103Absence seizures (HP:0002121)2.06942640
104Broad-based gait (HP:0002136)2.06035417
105Diplopia (HP:0000651)2.05970692
106Abnormality of binocular vision (HP:0011514)2.05970692
107Urinary bladder sphincter dysfunction (HP:0002839)2.05951909
108Impaired smooth pursuit (HP:0007772)2.05118234
109Mediastinal lymphadenopathy (HP:0100721)2.04781781
110Chronic otitis media (HP:0000389)2.04171190
111Glomerulopathy (HP:0100820)2.02086933
112Vertigo (HP:0002321)2.01847559
113Fatigue (HP:0012378)2.00952108
114Recurrent skin infections (HP:0001581)2.00291973
115Amyloidosis (HP:0011034)1.98625868
116Abnormality of cells of the lymphoid lineage (HP:0012140)1.98589779
117Eosinophilia (HP:0001880)1.96822271
118Hypoplasia of the thymus (HP:0000778)1.96263079
119Keratitis (HP:0000491)1.96252656
120Neoplasm of the tracheobronchial system (HP:0100552)1.95240855
121Mitral stenosis (HP:0001718)1.94959964
122Depression (HP:0000716)1.94203595
123Abnormal hair whorl (HP:0010721)1.92002422
124Skin ulcer (HP:0200042)1.92002117
125Acute hepatic failure (HP:0006554)1.91985864
126Increased IgM level (HP:0003496)1.91474247
127Cheilitis (HP:0100825)1.91455516
128Chronic diarrhea (HP:0002028)1.91234887
129Abnormality of ocular smooth pursuit (HP:0000617)1.90743364
130Increased cerebral lipofuscin (HP:0011813)1.90042616
131Autoimmune thrombocytopenia (HP:0001973)1.87876497
132Emphysema (HP:0002097)1.87641660
133Polyneuropathy (HP:0001271)1.87228748
134Resting tremor (HP:0002322)1.87227162
135Progressive inability to walk (HP:0002505)1.86401898
136Hyperacusis (HP:0010780)1.85665865
137Disinhibition (HP:0000734)1.84627744
138Recurrent otitis media (HP:0000403)1.83550107
139Amaurosis fugax (HP:0100576)1.83416590
140Mutism (HP:0002300)1.81232335
141Abnormal platelet volume (HP:0011876)1.80840038
142Neuronal loss in central nervous system (HP:0002529)1.79349382
143Dialeptic seizures (HP:0011146)1.79292456
144Stomach cancer (HP:0012126)1.79196694
145Stereotypic behavior (HP:0000733)1.78472619
146Hypergammaglobulinemia (HP:0010702)1.78142685
147Thrombophlebitis (HP:0004418)1.78123195
148Recurrent pneumonia (HP:0006532)1.75807343
149Abnormality of the intervertebral disk (HP:0005108)1.75702947
150IgG deficiency (HP:0004315)1.75581736
151Urinary urgency (HP:0000012)1.73945076
152Abnormal social behavior (HP:0012433)1.73773532
153Impaired social interactions (HP:0000735)1.73773532
154Severe combined immunodeficiency (HP:0004430)1.72512481
155Volvulus (HP:0002580)1.69861893
156Excessive salivation (HP:0003781)1.68741489
157Drooling (HP:0002307)1.68741489
158Scanning speech (HP:0002168)1.65660312
159Spontaneous hematomas (HP:0007420)1.65503122
160Dysmetria (HP:0001310)1.64838178
161Narrow palate (HP:0000189)1.64077308
162Pointed chin (HP:0000307)1.62870322

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.88284888
2MAP4K13.24658368
3MAP3K103.22111235
4SIK22.87778448
5TXK2.62620558
6MAP2K32.47430225
7FES2.26330453
8GRK62.14677934
9NTRK32.07030520
10MAP3K132.05768729
11CAMK1G2.04733265
12MAP3K91.97239760
13SYK1.91796565
14SGK31.73231163
15MAP3K41.68709742
16SGK21.66747812
17CSF1R1.64710568
18EPHB11.61524719
19TNK21.60314114
20JAK11.56896002
21FRK1.48092244
22PRKCH1.41733400
23HCK1.35985047
24FGFR31.31172796
25EEF2K1.30245030
26CAMK1D1.28720508
27IRAK11.28471402
28YES11.25535249
29TAOK31.25139976
30DAPK21.21660468
31BTK1.21287535
32MAP3K11.21149375
33CAMKK11.19882110
34CDK121.17268049
35PIK3CG1.16785387
36TYK21.16394455
37ALK1.15324125
38BLK1.15045159
39MAP3K121.12347723
40SIK31.12020032
41PDK11.11696162
42KIT1.09413506
43MAP3K141.08583350
44MAP2K71.07355473
45MAP3K31.06580675
46SGK2231.05551448
47SGK4941.05551448
48MINK11.03093206
49TBK11.01027666
50PRPF4B0.99574902
51EPHA40.97828851
52CLK10.97262258
53IKBKB0.97132741
54TGFBR20.96298119
55IRAK20.95830826
56NLK0.94888037
57MAP3K70.92091890
58HIPK20.91962914
59STK110.90553420
60BRD40.89710767
61NTRK20.89614068
62LCK0.86517461
63MAP2K40.86062153
64CDC42BPA0.85379083
65SGK10.85003431
66ITK0.84331427
67MARK20.83868384
68LYN0.83028684
69MARK30.82354399
70RIPK10.80967195
71FGFR20.78838530
72STK380.78612832
73CSK0.78271857
74KSR20.76586445
75CDK50.75544404
76MAP3K60.75248585
77RET0.74207468
78JAK30.73697664
79CDK90.73630812
80FYN0.73284863
81PDPK10.72608697
82SCYL20.72101907
83ZAP700.71721761
84MAP3K110.71661625
85MAPK130.69339886
86PNCK0.69205610
87MAPK120.69195949
88EPHA30.68134396
89DAPK10.67731666
90CAMK10.66828964
91PIM10.66323858
92FGFR40.66103225
93CAMKK20.63839504
94MAPK70.62823021
95JAK20.62810834
96PRKD20.62018274
97PAK60.61899534
98IKBKE0.58474300
99PRKCQ0.57579788
100IRAK40.57408605
101MATK0.57218285
102STK100.56956790
103FGR0.55687979
104NEK90.55402924
105TAOK10.55187776
106CAMK40.54786711
107BMPR20.54393253
108TRPM70.53234657
109TEC0.53132507
110RAF10.51206797
111PTK60.50145321
112MAP3K50.49868905
113PKN20.49744126
114GRK10.49134113
115RPS6KA20.48793817
116PRKD10.48384419
117ERN10.46803933
118DMPK0.46592075
119RPS6KC10.45850772
120RPS6KL10.45850772
121PTK2B0.45453847
122ACVR1B0.45329592
123RPS6KA60.45075781
124MAP3K20.44895919
125CHUK0.43171178
126LRRK20.42728904
127MAP2K60.42385949
128KSR10.40629342
129DYRK1B0.40121372

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.49979225
2Staphylococcus aureus infection_Homo sapiens_hsa051502.24561571
3Graft-versus-host disease_Homo sapiens_hsa053322.06013310
4Olfactory transduction_Homo sapiens_hsa047402.03531458
5Primary immunodeficiency_Homo sapiens_hsa053402.03089980
6Allograft rejection_Homo sapiens_hsa053302.02062890
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.93387674
8Autoimmune thyroid disease_Homo sapiens_hsa053201.91426465
9Long-term potentiation_Homo sapiens_hsa047201.78790751
10Morphine addiction_Homo sapiens_hsa050321.69110404
11Synaptic vesicle cycle_Homo sapiens_hsa047211.65073962
12Phosphatidylinositol signaling system_Homo sapiens_hsa040701.61173449
13Circadian entrainment_Homo sapiens_hsa047131.58803187
14Nicotine addiction_Homo sapiens_hsa050331.58604793
15Type I diabetes mellitus_Homo sapiens_hsa049401.56050697
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.51328379
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.51201712
18Malaria_Homo sapiens_hsa051441.49813902
19Osteoclast differentiation_Homo sapiens_hsa043801.49535383
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.47313167
21Glutamatergic synapse_Homo sapiens_hsa047241.45171356
22Salivary secretion_Homo sapiens_hsa049701.43019027
23Phototransduction_Homo sapiens_hsa047441.35717081
24Gastric acid secretion_Homo sapiens_hsa049711.33594882
25GABAergic synapse_Homo sapiens_hsa047271.30956324
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.30922118
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.30048769
28Dopaminergic synapse_Homo sapiens_hsa047281.27829825
29Cholinergic synapse_Homo sapiens_hsa047251.27446235
30Type II diabetes mellitus_Homo sapiens_hsa049301.26605304
31Chemokine signaling pathway_Homo sapiens_hsa040621.26475318
32Legionellosis_Homo sapiens_hsa051341.25859229
33Antigen processing and presentation_Homo sapiens_hsa046121.25482746
34Asthma_Homo sapiens_hsa053101.24704791
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24342286
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.22643073
37Glioma_Homo sapiens_hsa052141.19952399
38Oxytocin signaling pathway_Homo sapiens_hsa049211.16993601
39Amphetamine addiction_Homo sapiens_hsa050311.16920434
40Renin secretion_Homo sapiens_hsa049241.16480080
41Herpes simplex infection_Homo sapiens_hsa051681.15979907
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.14496725
43Viral myocarditis_Homo sapiens_hsa054161.14282445
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13814624
45Non-small cell lung cancer_Homo sapiens_hsa052231.13045550
46Leishmaniasis_Homo sapiens_hsa051401.12826864
47T cell receptor signaling pathway_Homo sapiens_hsa046601.12424270
48Dorso-ventral axis formation_Homo sapiens_hsa043201.11946759
49Insulin secretion_Homo sapiens_hsa049111.11610980
50GnRH signaling pathway_Homo sapiens_hsa049121.08610629
51Long-term depression_Homo sapiens_hsa047301.08492230
52Hematopoietic cell lineage_Homo sapiens_hsa046401.07901892
53Platelet activation_Homo sapiens_hsa046111.06402297
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02962202
55Tuberculosis_Homo sapiens_hsa051521.02526355
56Hepatitis C_Homo sapiens_hsa051601.01681581
57Inositol phosphate metabolism_Homo sapiens_hsa005621.01508245
58Phagosome_Homo sapiens_hsa041451.01339236
59Calcium signaling pathway_Homo sapiens_hsa040200.99684060
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.99183724
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.97906847
62Estrogen signaling pathway_Homo sapiens_hsa049150.96809969
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96185072
64Taste transduction_Homo sapiens_hsa047420.95524509
65Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94563140
66cAMP signaling pathway_Homo sapiens_hsa040240.94042720
67ErbB signaling pathway_Homo sapiens_hsa040120.93279880
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92606683
69Chronic myeloid leukemia_Homo sapiens_hsa052200.91511193
70mTOR signaling pathway_Homo sapiens_hsa041500.89373133
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.88896135
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88130253
73MAPK signaling pathway_Homo sapiens_hsa040100.88016698
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87823544
75Choline metabolism in cancer_Homo sapiens_hsa052310.86944706
76Apoptosis_Homo sapiens_hsa042100.86930776
77Rheumatoid arthritis_Homo sapiens_hsa053230.86807154
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86701792
79VEGF signaling pathway_Homo sapiens_hsa043700.86042785
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85614614
81Pertussis_Homo sapiens_hsa051330.85021924
82Serotonergic synapse_Homo sapiens_hsa047260.82111808
83Pancreatic cancer_Homo sapiens_hsa052120.81888173
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80896644
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78889442
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77131111
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.76181726
88Endocytosis_Homo sapiens_hsa041440.76017034
89Other glycan degradation_Homo sapiens_hsa005110.75812402
90Endometrial cancer_Homo sapiens_hsa052130.75666986
91Measles_Homo sapiens_hsa051620.75565240
92Toxoplasmosis_Homo sapiens_hsa051450.75159658
93Acute myeloid leukemia_Homo sapiens_hsa052210.74832150
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.74739896
95Influenza A_Homo sapiens_hsa051640.70413338
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.70314624
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70218985
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70120167
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69909793
100Pancreatic secretion_Homo sapiens_hsa049720.68723134
101Cocaine addiction_Homo sapiens_hsa050300.68353131
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68219829
103Hepatitis B_Homo sapiens_hsa051610.68195256
104Renal cell carcinoma_Homo sapiens_hsa052110.67513502
105FoxO signaling pathway_Homo sapiens_hsa040680.67486909
106Notch signaling pathway_Homo sapiens_hsa043300.67435244
107Insulin resistance_Homo sapiens_hsa049310.65917735
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65552430
109Salmonella infection_Homo sapiens_hsa051320.65074329
110Colorectal cancer_Homo sapiens_hsa052100.63199931
111Collecting duct acid secretion_Homo sapiens_hsa049660.62983755
112Prolactin signaling pathway_Homo sapiens_hsa049170.62306242
113Gap junction_Homo sapiens_hsa045400.62229864
114Viral carcinogenesis_Homo sapiens_hsa052030.60626923
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.60074599
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.60009943
117Amoebiasis_Homo sapiens_hsa051460.59615609
118Rap1 signaling pathway_Homo sapiens_hsa040150.58470686
119Epstein-Barr virus infection_Homo sapiens_hsa051690.56882312
120Prostate cancer_Homo sapiens_hsa052150.55783726
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55332966
122TNF signaling pathway_Homo sapiens_hsa046680.54999528
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54822676
124HIF-1 signaling pathway_Homo sapiens_hsa040660.54780782
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54388636
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.54274989
127Shigellosis_Homo sapiens_hsa051310.53619877
128African trypanosomiasis_Homo sapiens_hsa051430.53363185
129Thyroid hormone synthesis_Homo sapiens_hsa049180.53131775
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51555825
131HTLV-I infection_Homo sapiens_hsa051660.50371211
132Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50229562
133Lysosome_Homo sapiens_hsa041420.47643593
134Regulation of autophagy_Homo sapiens_hsa041400.47484863
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46331301
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.43871675
137Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43509417

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