SLC12A7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lysine metabolic process (GO:0006553)5.19726372
2lysine catabolic process (GO:0006554)5.19726372
3L-phenylalanine metabolic process (GO:0006558)4.62891455
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.62891455
52-oxoglutarate metabolic process (GO:0006103)4.62521094
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.52455618
7L-phenylalanine catabolic process (GO:0006559)4.52455618
8glyoxylate metabolic process (GO:0046487)4.50043025
9fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.23583844
10bundle of His cell to Purkinje myocyte communication (GO:0086069)4.23480925
11fatty acid beta-oxidation (GO:0006635)4.18941246
12kynurenine metabolic process (GO:0070189)4.18543648
13carnitine shuttle (GO:0006853)4.14604791
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.13493861
15fatty acid transmembrane transport (GO:1902001)4.11838223
16alpha-linolenic acid metabolic process (GO:0036109)4.00414027
17amino-acid betaine metabolic process (GO:0006577)3.97386679
18aromatic amino acid family catabolic process (GO:0009074)3.95471011
19sarcomere organization (GO:0045214)3.89825610
20phospholipid homeostasis (GO:0055091)3.89786607
21sulfur amino acid catabolic process (GO:0000098)3.89677867
22negative regulation of erythrocyte differentiation (GO:0045647)3.87511557
23aspartate family amino acid catabolic process (GO:0009068)3.87204002
24tricarboxylic acid metabolic process (GO:0072350)3.83776654
25fatty acid oxidation (GO:0019395)3.82813047
26serine family amino acid catabolic process (GO:0009071)3.78229217
27tricarboxylic acid cycle (GO:0006099)3.73613479
28regulation of cholesterol homeostasis (GO:2000188)3.73254970
29lipid oxidation (GO:0034440)3.72518846
30regulation of triglyceride catabolic process (GO:0010896)3.69161878
31homocysteine metabolic process (GO:0050667)3.68428399
32positive regulation of fatty acid beta-oxidation (GO:0032000)3.67502517
33cysteine metabolic process (GO:0006534)3.66059367
34acetyl-CoA metabolic process (GO:0006084)3.65341988
35valine metabolic process (GO:0006573)3.64478587
36fatty acid catabolic process (GO:0009062)3.64471899
37indole-containing compound catabolic process (GO:0042436)3.55092823
38indolalkylamine catabolic process (GO:0046218)3.55092823
39tryptophan catabolic process (GO:0006569)3.55092823
40mannose metabolic process (GO:0006013)3.54348118
41ethanol oxidation (GO:0006069)3.52838877
42short-chain fatty acid metabolic process (GO:0046459)3.51875073
43negative regulation of fibrinolysis (GO:0051918)3.49115746
44tryptophan metabolic process (GO:0006568)3.47590204
45carnitine metabolic process (GO:0009437)3.47554176
46cardiac myofibril assembly (GO:0055003)3.42498649
47antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.42041969
48negative regulation of fatty acid biosynthetic process (GO:0045717)3.38670168
49monocarboxylic acid catabolic process (GO:0072329)3.37356217
504-hydroxyproline metabolic process (GO:0019471)3.37287340
51bile acid biosynthetic process (GO:0006699)3.36587073
52fatty acid homeostasis (GO:0055089)3.36123533
53antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.35130911
54antigen processing and presentation of endogenous antigen (GO:0019883)3.35069465
55urea cycle (GO:0000050)3.34452211
56urea metabolic process (GO:0019627)3.34452211
57regulation of fatty acid oxidation (GO:0046320)3.32964960
58positive regulation of Cdc42 GTPase activity (GO:0043089)3.32175516
59glycine metabolic process (GO:0006544)3.32025184
60peptidyl-glutamic acid carboxylation (GO:0017187)3.29647038
61protein carboxylation (GO:0018214)3.29647038
62regulation of fatty acid beta-oxidation (GO:0031998)3.29108496
63cellular ketone body metabolic process (GO:0046950)3.28140453
64oxaloacetate metabolic process (GO:0006107)3.27638182
65NADH metabolic process (GO:0006734)3.26068998
66positive regulation of fatty acid oxidation (GO:0046321)3.25351093
67negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.24817649
68acylglycerol homeostasis (GO:0055090)3.23854559
69triglyceride homeostasis (GO:0070328)3.23854559
70high-density lipoprotein particle remodeling (GO:0034375)3.22070821
71alpha-amino acid catabolic process (GO:1901606)3.21592737
72amino-acid betaine transport (GO:0015838)3.18865589
73carnitine transport (GO:0015879)3.18865589
74cellular modified amino acid catabolic process (GO:0042219)3.17253267
75carnitine transmembrane transport (GO:1902603)3.15866446
76regulation of protein activation cascade (GO:2000257)3.15247413
77regulation of sequestering of triglyceride (GO:0010889)3.14977206
78tyrosine metabolic process (GO:0006570)3.14823922
79detection of bacterium (GO:0016045)3.12610995
80biotin metabolic process (GO:0006768)3.11840202
81complement activation, alternative pathway (GO:0006957)3.11481260
82regulation of cholesterol metabolic process (GO:0090181)3.09783897
83epoxygenase P450 pathway (GO:0019373)3.09214670
84negative regulation of sterol transport (GO:0032372)3.09075764
85negative regulation of cholesterol transport (GO:0032375)3.09075764
86dicarboxylic acid biosynthetic process (GO:0043650)3.08119876
87aromatic amino acid family metabolic process (GO:0009072)3.07673858
88regulation of fibrinolysis (GO:0051917)3.06551897
89detection of other organism (GO:0098543)3.05130836
90cellular amino acid catabolic process (GO:0009063)3.04924686
91bile acid metabolic process (GO:0008206)3.04670600
92plasma lipoprotein particle clearance (GO:0034381)3.04030480
93cardiac muscle cell development (GO:0055013)3.03168363
94ketone body metabolic process (GO:1902224)3.02844915
95nitrogen cycle metabolic process (GO:0071941)3.01520315
96cholesterol homeostasis (GO:0042632)3.00750935
97organic acid catabolic process (GO:0016054)3.00605849
98carboxylic acid catabolic process (GO:0046395)3.00605849
99drug catabolic process (GO:0042737)3.00284030
100branched-chain amino acid metabolic process (GO:0009081)3.00199793
101phospholipid efflux (GO:0033700)2.98646821
102negative regulation of potassium ion transmembrane transport (GO:1901380)2.98270517
103regulation of complement activation (GO:0030449)2.97455232
104response to peptidoglycan (GO:0032494)2.97450915
105sterol homeostasis (GO:0055092)2.97230450
106branched-chain amino acid catabolic process (GO:0009083)2.96617356
107intestinal cholesterol absorption (GO:0030299)2.96248940
108urate metabolic process (GO:0046415)2.95319410
109ventricular cardiac muscle cell action potential (GO:0086005)2.93165040
110response to muramyl dipeptide (GO:0032495)2.89203506
111NIK/NF-kappaB signaling (GO:0038061)2.89183039
112germinal center formation (GO:0002467)2.80860392
113apoptotic process involved in morphogenesis (GO:0060561)2.78501897
114positive regulation of gamma-delta T cell activation (GO:0046645)2.77811375
115epithelial cell differentiation involved in prostate gland development (GO:0060742)2.77750240
116regulation of apoptotic cell clearance (GO:2000425)2.76592633
117positive regulation of lipoprotein lipase activity (GO:0051006)2.69705978
118positive regulation of triglyceride lipase activity (GO:0061365)2.69705978
119glycosphingolipid catabolic process (GO:0046479)2.68868907
120pinocytosis (GO:0006907)2.65026952
121response to laminar fluid shear stress (GO:0034616)2.64379842
122antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.63606870
123regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.61320388
124modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.59493391
125positive regulation by organism of defense response of other organism involved in symbiotic interact2.59493391
126modulation by symbiont of host immune response (GO:0052553)2.59493391
127positive regulation by symbiont of host defense response (GO:0052509)2.59493391
128modulation by symbiont of host defense response (GO:0052031)2.59493391
129modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.59493391
130negative regulation of cell killing (GO:0031342)2.59110120
131negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.59110120
132regulation of gamma-delta T cell activation (GO:0046643)2.58625161
133barbed-end actin filament capping (GO:0051016)2.58175678
134macrophage activation involved in immune response (GO:0002281)2.57903958
135negative regulation of myotube differentiation (GO:0010832)2.55782377
136regulation of extracellular matrix disassembly (GO:0010715)2.55205791
137peptide catabolic process (GO:0043171)2.55073332
138positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.54641322
139atrioventricular valve morphogenesis (GO:0003181)2.53784049
140positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.53210474
141positive regulation of histone deacetylation (GO:0031065)2.51769751
142detection of external biotic stimulus (GO:0098581)2.50678688
143regulation of glucose import in response to insulin stimulus (GO:2001273)2.46793655
144epithelial cell-cell adhesion (GO:0090136)2.46418066
145glycolipid catabolic process (GO:0019377)2.44665920
146cell-cell junction maintenance (GO:0045217)2.41813523
147negative regulation of granulocyte differentiation (GO:0030853)2.41809270
148regulation of gamma-delta T cell differentiation (GO:0045586)2.41349315
149plasma lipoprotein particle assembly (GO:0034377)2.40742480
150immunoglobulin mediated immune response (GO:0016064)2.40009538
151positive regulation of lipid catabolic process (GO:0050996)2.39403413
152angiotensin maturation (GO:0002003)2.39147086
153semaphorin-plexin signaling pathway (GO:0071526)2.37839285
154regulation of myeloid leukocyte mediated immunity (GO:0002886)2.36747855
155regulation of leukocyte degranulation (GO:0043300)2.36006329
156protein-lipid complex assembly (GO:0065005)2.35949646
157complement activation, classical pathway (GO:0006958)2.35892580
158regulation of extracellular matrix organization (GO:1903053)2.35575146
159regulation of cholesterol storage (GO:0010885)2.33791900
160negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.32845590
161cellular response to thyroid hormone stimulus (GO:0097067)2.32204998
162ethanol metabolic process (GO:0006067)2.31364141
163regulation of cholesterol esterification (GO:0010872)2.31103129
164acute-phase response (GO:0006953)2.31063120
165positive thymic T cell selection (GO:0045059)2.29332115
166complement activation (GO:0006956)2.29055042
167regulation of dendritic cell antigen processing and presentation (GO:0002604)2.28998143
168glucose 6-phosphate metabolic process (GO:0051156)2.28277008
169desmosome organization (GO:0002934)2.28214579
170negative regulation of fatty acid transport (GO:2000192)2.27550615
171negative regulation of viral release from host cell (GO:1902187)2.24391184
172positive regulation of receptor recycling (GO:0001921)2.23997901
173detection of biotic stimulus (GO:0009595)2.22651280
174activation of MAPKKK activity (GO:0000185)2.20414278
175protein localization to endosome (GO:0036010)2.20094750
176adhesion of symbiont to host (GO:0044406)2.20035569
177thymic T cell selection (GO:0045061)2.19345562
178very-low-density lipoprotein particle assembly (GO:0034379)2.19022269
179cellular response to virus (GO:0098586)2.18975536
180fat-soluble vitamin biosynthetic process (GO:0042362)2.18956392
181positive regulation of extracellular matrix organization (GO:1903055)2.17824046
182regulation of endothelial cell chemotaxis (GO:2001026)2.17586961
183response to type I interferon (GO:0034340)2.17575442
184lipopolysaccharide-mediated signaling pathway (GO:0031663)2.17422541
185modulation by symbiont of host cellular process (GO:0044068)2.17391858
186negative regulation of toll-like receptor signaling pathway (GO:0034122)2.16000178
187positive regulation of protein deacetylation (GO:0090312)2.15825425
188neutrophil activation involved in immune response (GO:0002283)2.14289822
189regulation of necroptotic process (GO:0060544)2.12692794

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.73288757
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.05791914
3* RXR_22158963_ChIP-Seq_LIVER_Mouse4.95320178
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.77233740
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.03862225
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.18226451
7EGR1_23403033_ChIP-Seq_LIVER_Mouse2.76873263
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.74441630
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.71017031
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.50472483
11CLOCK_20551151_ChIP-Seq_293T_Human2.45458960
12ZNF263_19887448_ChIP-Seq_K562_Human2.39746358
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.07602949
14RARG_19884340_ChIP-ChIP_MEFs_Mouse1.96878223
15BP1_19119308_ChIP-ChIP_Hs578T_Human1.91852021
16VDR_24763502_ChIP-Seq_THP-1_Human1.91055151
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.86830385
18TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.86569436
19STAT3_1855785_ChIP-Seq_MESCs_Mouse1.84510953
20STAT6_21828071_ChIP-Seq_BEAS2B_Human1.81769110
21TP63_17297297_ChIP-ChIP_HaCaT_Human1.73143340
22MYC_22102868_ChIP-Seq_BL_Human1.70664175
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.70138202
24* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.66934997
25* KDM2B_26808549_Chip-Seq_K562_Human1.64911795
26TBX20_22080862_ChIP-Seq_HEART_Mouse1.61438568
27TBX20_22328084_ChIP-Seq_HEART_Mouse1.61438568
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59834888
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59169223
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.56147569
31* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54001489
32HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.52651849
33* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.47644775
34* SMC4_20622854_ChIP-Seq_HELA_Human1.46863968
35RACK7_27058665_Chip-Seq_MCF-7_Human1.46054979
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45360126
37* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43704437
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43242145
39MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.39852595
40KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38729844
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.37403631
42SA1_27219007_Chip-Seq_ERYTHROID_Human1.37206824
43ESR2_21235772_ChIP-Seq_MCF-7_Human1.36700472
44GATA1_19941827_ChIP-Seq_MEL_Mouse1.35322702
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.34817926
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.34469673
47TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.33901076
48SCL_19346495_ChIP-Seq_HPC-7_Human1.33813933
49CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31985265
50RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.31859754
51LXR_22292898_ChIP-Seq_THP-1_Human1.30946717
52TET1_21451524_ChIP-Seq_MESCs_Mouse1.29967482
53* KDM2B_26808549_Chip-Seq_JURKAT_Human1.29080814
54* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27848794
55SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27772723
56ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.27064046
57TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26104519
58ATF3_27146783_Chip-Seq_COLON_Human1.26029957
59SPI1_23127762_ChIP-Seq_K562_Human1.25776997
60UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.25463720
61GATA1_22025678_ChIP-Seq_K562_Human1.23800225
62IRF8_27001747_Chip-Seq_BMDM_Mouse1.22997224
63* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22935348
64ESR1_21235772_ChIP-Seq_MCF-7_Human1.22697025
65HIF1A_21447827_ChIP-Seq_MCF-7_Human1.21540573
66BCL6_27268052_Chip-Seq_Bcells_Human1.21536200
67* GATA1_19941826_ChIP-Seq_K562_Human1.21129455
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21061362
69FOXA2_19822575_ChIP-Seq_HepG2_Human1.20993203
70KDM2B_26808549_Chip-Seq_DND41_Human1.19901309
71GATA6_25053715_ChIP-Seq_YYC3_Human1.19710865
72MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18336842
73GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17459375
74ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16790167
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16703482
76SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16174718
77EGR1_19374776_ChIP-ChIP_THP-1_Human1.16121977
78MAF_26560356_Chip-Seq_TH2_Human1.15775519
79TCF7_22412390_ChIP-Seq_EML_Mouse1.15049259
80DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14779943
81SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13436088
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12171350
83* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11678454
84SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11357247
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11278433
86KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11109946
87SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10692076
88STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10592931
89ELF1_20517297_ChIP-Seq_JURKAT_Human1.10177648
90* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08460228
91IRF8_21731497_ChIP-ChIP_J774_Mouse1.07815692
92MAF_26560356_Chip-Seq_TH1_Human1.07594273
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06946269
94CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06473482
95TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05675304
96CDX2_20551321_ChIP-Seq_CACO-2_Human1.05621396
97EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.05174411
98ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03945054
99SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03810396
100FOXO3_23340844_ChIP-Seq_DLD1_Human1.03708102
101CTCF_27219007_Chip-Seq_Bcells_Human1.03522233
102TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02848927
103CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02677720
104MYB_21317192_ChIP-Seq_ERMYB_Mouse1.01364530
105UTX_26944678_Chip-Seq_JUKART_Human1.01074996
106P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00581520
107RUNX1_27514584_Chip-Seq_MCF-7_Human1.00258944
108* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00122167
109* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00069856
110TP63_22573176_ChIP-Seq_HFKS_Human0.99857374
111NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.99809571
112* HNF4A_19822575_ChIP-Seq_HepG2_Human0.99664744
113IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99589209
114NCOR1_26117541_ChIP-Seq_K562_Human0.98768299
115VDR_21846776_ChIP-Seq_THP-1_Human0.98616718
116CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97196781
117P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95820277
118GATA4_25053715_ChIP-Seq_YYC3_Human0.95612529
119SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93688392
120TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92041014
121STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.91852954
122ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91467566
123PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90632430
124RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.89834034
125* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.89335676
126KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.87776318
127KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.87776318
128KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.87776318
129NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87247254
130CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87059388
131* P68_20966046_ChIP-Seq_HELA_Human0.85347746
132AR_21909140_ChIP-Seq_LNCAP_Human0.85018614
133* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.84552897
134BCOR_27268052_Chip-Seq_Bcells_Human0.84511672
135CREB1_26743006_Chip-Seq_LNCaP_Human0.84142796
136SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83611903
137* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83390263
138FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.83237089
139SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.83129599
140BRD4_27068464_Chip-Seq_AML-cells_Mouse0.82452790
141RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.80994533
142FOXM1_23109430_ChIP-Seq_U2OS_Human0.79877796
143* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.79850370
144GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.79694754
145EP300_21415370_ChIP-Seq_HL-1_Mouse0.77253230
146* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.76952230
147IRF8_22096565_ChIP-ChIP_GC-B_Human0.75129745
148NANOG_18555785_ChIP-Seq_MESCs_Mouse0.74561582

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.68880947
2MP0002139_abnormal_hepatobiliary_system4.60501167
3MP0005085_abnormal_gallbladder_physiolo3.77973435
4MP0005365_abnormal_bile_salt3.71659516
5MP0002837_dystrophic_cardiac_calcinosis3.66336133
6MP0003806_abnormal_nucleotide_metabolis3.11432150
7MP0004084_abnormal_cardiac_muscle2.90333534
8MP0009840_abnormal_foam_cell2.87530280
9MP0003252_abnormal_bile_duct2.81579309
10MP0008875_abnormal_xenobiotic_pharmacok2.72224342
11MP0003436_decreased_susceptibility_to2.66544339
12MP0003303_peritoneal_inflammation2.60511451
13MP0003705_abnormal_hypodermis_morpholog2.50319638
14MP0010329_abnormal_lipoprotein_level2.21508570
15MP0005330_cardiomyopathy2.14784590
16MP0003172_abnormal_lysosome_physiology2.12459814
17MP0005670_abnormal_white_adipose2.05667124
18MP0003646_muscle_fatigue2.01948550
19MP0005409_darkened_coat_color1.96021035
20MP0004215_abnormal_myocardial_fiber1.94577940
21MP0010155_abnormal_intestine_physiology1.91999674
22MP0005083_abnormal_biliary_tract1.88129176
23MP0009278_abnormal_bone_marrow1.82258157
24MP0005076_abnormal_cell_differentiation1.80402742
25MP0001666_abnormal_nutrient_absorption1.78364874
26MP0005332_abnormal_amino_acid1.78052467
27MP0004947_skin_inflammation1.76460774
28MP0004036_abnormal_muscle_relaxation1.75962787
29MP0003724_increased_susceptibility_to1.75204803
30MP0000751_myopathy1.74542264
31MP0008260_abnormal_autophagy1.73717938
32MP0005025_abnormal_response_to1.73189875
33MP0003195_calcinosis1.71484775
34MP0004130_abnormal_muscle_cell1.71277930
35MP0000609_abnormal_liver_physiology1.69615990
36MP0003191_abnormal_cellular_cholesterol1.67855900
37MP0002419_abnormal_innate_immunity1.67354089
38MP0003453_abnormal_keratinocyte_physiol1.64536149
39MP0000685_abnormal_immune_system1.64143849
40MP0004858_abnormal_nervous_system1.64043815
41MP0001873_stomach_inflammation1.61460468
42MP0010630_abnormal_cardiac_muscle1.61154518
43MP0002254_reproductive_system_inflammat1.59704234
44MP0005387_immune_system_phenotype1.57997637
45MP0001790_abnormal_immune_system1.57997637
46MP0001835_abnormal_antigen_presentation1.56974858
47MP0005666_abnormal_adipose_tissue1.55408623
48MP0004087_abnormal_muscle_fiber1.51167157
49MP0005319_abnormal_enzyme/_coenzyme1.50767254
50MP0009785_altered_susceptibility_to1.48329992
51MP0002269_muscular_atrophy1.47670411
52MP0010368_abnormal_lymphatic_system1.45107986
53MP0000858_altered_metastatic_potential1.44398020
54MP0006082_CNS_inflammation1.43063343
55MP0008775_abnormal_heart_ventricle1.41361119
56MP0001544_abnormal_cardiovascular_syste1.38237459
57MP0005385_cardiovascular_system_phenoty1.38237459
58MP0002118_abnormal_lipid_homeostasis1.38152068
59MP0003566_abnormal_cell_adhesion1.35810729
60MP0002148_abnormal_hypersensitivity_rea1.34009054
61MP0002998_abnormal_bone_remodeling1.33629542
62MP0001533_abnormal_skeleton_physiology1.32824335
63* MP0009643_abnormal_urine_homeostasis1.32704454
64MP0002138_abnormal_hepatobiliary_system1.32126637
65MP0000750_abnormal_muscle_regeneration1.31297882
66MP0005000_abnormal_immune_tolerance1.30958141
67MP0002972_abnormal_cardiac_muscle1.29870043
68MP0004185_abnormal_adipocyte_glucose1.27393147
69MP0001800_abnormal_humoral_immune1.26953720
70MP0003183_abnormal_peptide_metabolism1.26722456
71MP0000749_muscle_degeneration1.26388700
72MP0003866_abnormal_defecation1.25757493
73MP0006138_congestive_heart_failure1.25557664
74MP0009333_abnormal_splenocyte_physiolog1.25301811
75MP0004019_abnormal_vitamin_homeostasis1.24144677
76MP0005464_abnormal_platelet_physiology1.23840618
77MP0010352_gastrointestinal_tract_polyps1.22757776
78MP0000604_amyloidosis1.20178362
79MP0002452_abnormal_antigen_presenting1.19489510
80MP0003221_abnormal_cardiomyocyte_apopto1.19327300
81MP0006036_abnormal_mitochondrial_physio1.16833027
82MP0002723_abnormal_immune_serum1.14588816
83MP0003075_altered_response_to1.14348682
84MP0008469_abnormal_protein_level1.13635819
85MP0003763_abnormal_thymus_physiology1.13298711
86MP0005671_abnormal_response_to1.13255382
87MP0003828_pulmonary_edema1.12749781
88MP0003878_abnormal_ear_physiology1.12698486
89MP0005377_hearing/vestibular/ear_phenot1.12698486
90MP0000678_abnormal_parathyroid_gland1.12689294
91MP0004510_myositis1.12030528
92MP0002166_altered_tumor_susceptibility1.11758998
93MP0008004_abnormal_stomach_pH1.11281966
94MP0001845_abnormal_inflammatory_respons1.11113935
95MP0003091_abnormal_cell_migration1.08627381
96MP0005310_abnormal_salivary_gland1.07688228
97MP0005397_hematopoietic_system_phenotyp1.05808294
98MP0001545_abnormal_hematopoietic_system1.05808294
99MP0001819_abnormal_immune_cell1.05608091
100MP0003300_gastrointestinal_ulcer1.04168433
101MP0002420_abnormal_adaptive_immunity1.04155248
102MP0002127_abnormal_cardiovascular_syste1.04118175
103MP0004381_abnormal_hair_follicle1.03504281
104MP0002405_respiratory_system_inflammati1.03396789
105MP0003567_abnormal_fetal_cardiomyocyte1.02800027
106MP0005375_adipose_tissue_phenotype1.02736681
107MP0002796_impaired_skin_barrier1.02633587
108MP0000598_abnormal_liver_morphology1.01020118
109MP0002877_abnormal_melanocyte_morpholog0.99499282
110MP0005166_decreased_susceptibility_to0.99234193
111MP0003137_abnormal_impulse_conducting0.99121620
112MP0000490_abnormal_crypts_of0.98665212
113MP0001851_eye_inflammation0.98098541
114MP0002132_abnormal_respiratory_system0.96875049
115MP0002933_joint_inflammation0.95835403
116MP0000343_altered_response_to0.95659426
117MP0000566_synostosis0.89969814
118MP0005620_abnormal_muscle_contractility0.87478908
119MP0000249_abnormal_blood_vessel0.87202453
120MP0003329_amyloid_beta_deposits0.86823580
121MP0001663_abnormal_digestive_system0.86822866
122MP0004264_abnormal_extraembryonic_tissu0.86161839
123MP0003279_aneurysm0.84835647
124MP0004043_abnormal_pH_regulation0.83799112
125MP0002106_abnormal_muscle_physiology0.83775333
126MP0002078_abnormal_glucose_homeostasis0.82216346
127MP0000716_abnormal_immune_system0.80368206
128MP0005451_abnormal_body_composition0.80240679
129MP0001853_heart_inflammation0.80093239
130MP0005023_abnormal_wound_healing0.78511192
131MP0002088_abnormal_embryonic_growth/wei0.78366897
132MP0002396_abnormal_hematopoietic_system0.77471011
133MP0000266_abnormal_heart_morphology0.77431850
134MP0003984_embryonic_growth_retardation0.77234191
135MP0000465_gastrointestinal_hemorrhage0.76544710
136MP0005266_abnormal_metabolism0.74964933
137MP0005584_abnormal_enzyme/coenzyme_acti0.74897113
138MP0001756_abnormal_urination0.74672841
139MP0008961_abnormal_basal_metabolism0.72091068
140MP0003283_abnormal_digestive_organ0.70448730
141MP0002971_abnormal_brown_adipose0.70245452
142MP0009763_increased_sensitivity_to0.69355757
143MP0000747_muscle_weakness0.69109398
144MP0002128_abnormal_blood_circulation0.68255849
145MP0003868_abnormal_feces_composition0.68140224
146MP0001672_abnormal_embryogenesis/_devel0.67617745
147MP0005380_embryogenesis_phenotype0.67617745
148MP0005058_abnormal_lysosome_morphology0.64987180
149MP0000003_abnormal_adipose_tissue0.62920121
150MP0001849_ear_inflammation0.62580299
151MP0004484_altered_response_of0.61660709
152MP0010234_abnormal_vibrissa_follicle0.61354390
153MP0009642_abnormal_blood_homeostasis0.61210875
154MP0000767_abnormal_smooth_muscle0.61037270
155MP0005334_abnormal_fat_pad0.60880005
156MP0003186_abnormal_redox_activity0.60787562
157MP0004085_abnormal_heartbeat0.60680168
158MP0002086_abnormal_extraembryonic_tissu0.60356600
159MP0006035_abnormal_mitochondrial_morpho0.60054811
160MP0000371_diluted_coat_color0.59798915
161MP0005369_muscle_phenotype0.59048364
162MP0009053_abnormal_anal_canal0.58668444
163MP0001661_extended_life_span0.57453364
164MP0005165_increased_susceptibility_to0.57338891
165MP0000759_abnormal_skeletal_muscle0.57201729
166MP0005187_abnormal_penis_morphology0.56452268

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.90518011
2Systemic lupus erythematosus (HP:0002725)4.56134680
3Ventricular tachycardia (HP:0004756)4.45812502
4Right ventricular cardiomyopathy (HP:0011663)4.33305131
5Sudden death (HP:0001699)4.30395192
6Intrahepatic cholestasis (HP:0001406)4.21270124
7Xanthomatosis (HP:0000991)4.17599071
8Deep venous thrombosis (HP:0002625)4.07862580
9Hyperglycinuria (HP:0003108)4.04792371
10Ketosis (HP:0001946)3.91709614
11Abnormality of monocarboxylic acid metabolism (HP:0010996)3.89126258
12Abnormality of aromatic amino acid family metabolism (HP:0004338)3.88441011
13Ketoacidosis (HP:0001993)3.81358437
14Hyperammonemia (HP:0001987)3.80409329
15Eczematoid dermatitis (HP:0000976)3.69013446
16Hemorrhage of the eye (HP:0011885)3.65506860
17Abnormality of fatty-acid metabolism (HP:0004359)3.63671757
18Myoglobinuria (HP:0002913)3.55253804
19Abnormality of glycine metabolism (HP:0010895)3.50360295
20Abnormality of serine family amino acid metabolism (HP:0010894)3.50360295
21Hyperinsulinemic hypoglycemia (HP:0000825)3.30201081
22Hypoalphalipoproteinemia (HP:0003233)3.29753257
23Hypobetalipoproteinemia (HP:0003563)3.28766639
24Malnutrition (HP:0004395)3.28214566
25Hyperglycinemia (HP:0002154)3.23632351
26Abnormality of dicarboxylic acid metabolism (HP:0010995)3.17826781
27Dicarboxylic aciduria (HP:0003215)3.17826781
28Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.16445036
29Hypolipoproteinemia (HP:0010981)3.14460501
30Hyperlipoproteinemia (HP:0010980)3.13658949
31Palpitations (HP:0001962)3.13613415
32Glomerulonephritis (HP:0000099)3.12529542
33Recurrent gram-negative bacterial infections (HP:0005420)3.10001006
34Lipoatrophy (HP:0100578)3.03710252
35Increased cerebral lipofuscin (HP:0011813)3.00038173
36Abnormality of glutamine family amino acid metabolism (HP:0010902)2.98507783
37Muscle fiber splitting (HP:0003555)2.95192031
38Asymmetric septal hypertrophy (HP:0001670)2.90884400
39Abnormality of macrophages (HP:0004311)2.90701748
40Hyporeflexia of lower limbs (HP:0002600)2.84655660
41Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.83269961
42Atrioventricular block (HP:0001678)2.82408107
43Dysostosis multiplex (HP:0000943)2.80006461
44Abnormality of liposaccharide metabolism (HP:0010968)2.79448819
45Abnormality of glycosphingolipid metabolism (HP:0004343)2.79448819
46Abnormality of glycolipid metabolism (HP:0010969)2.79448819
47Complement deficiency (HP:0004431)2.78190748
48Syncope (HP:0001279)2.77642613
49Abnormality of sulfur amino acid metabolism (HP:0004339)2.74229707
50Dilated cardiomyopathy (HP:0001644)2.73662877
51Atrial fibrillation (HP:0005110)2.73496456
52Hyperglycemia (HP:0003074)2.73457307
53Increased connective tissue (HP:0009025)2.73339557
54Hypoglycemic seizures (HP:0002173)2.71447132
55Skin nodule (HP:0200036)2.71207837
56Epidermoid cyst (HP:0200040)2.69687818
57Gout (HP:0001997)2.68284330
58Rhabdomyolysis (HP:0003201)2.68059765
59Generalized aminoaciduria (HP:0002909)2.68058693
60Late onset (HP:0003584)2.67912490
61Thin bony cortex (HP:0002753)2.67045757
62Distal lower limb muscle weakness (HP:0009053)2.66732480
63Exercise-induced muscle cramps (HP:0003710)2.65538058
64Bundle branch block (HP:0011710)2.63348805
65Broad face (HP:0000283)2.60572569
66Flat acetabular roof (HP:0003180)2.60543134
67Colitis (HP:0002583)2.60404581
68Prolonged partial thromboplastin time (HP:0003645)2.59882843
69Axonal loss (HP:0003447)2.57784900
70Recurrent abscess formation (HP:0002722)2.57754825
71Increased neuronal autofluorescent lipopigment (HP:0002074)2.56336528
72Loss of speech (HP:0002371)2.55924096
73Multiple enchondromatosis (HP:0005701)2.50624642
74Obstructive sleep apnea (HP:0002870)2.48630343
75Primary atrial arrhythmia (HP:0001692)2.47752157
76Cerebral aneurysm (HP:0004944)2.47056637
77Urinary glycosaminoglycan excretion (HP:0003541)2.46960875
78Mucopolysacchariduria (HP:0008155)2.46960875
79Hypercholesterolemia (HP:0003124)2.45511761
80Abnormality of purine metabolism (HP:0004352)2.45006262
81Purpura (HP:0000979)2.43556617
82Abnormality of polysaccharide metabolism (HP:0011012)2.41575792
83Abnormality of glycosaminoglycan metabolism (HP:0004371)2.41575792
84Abnormality of mucopolysaccharide metabolism (HP:0011020)2.41575792
85Abnormality of aspartate family amino acid metabolism (HP:0010899)2.40235724
86Heart block (HP:0012722)2.38685239
87Supraventricular tachycardia (HP:0004755)2.37997593
88Supraventricular arrhythmia (HP:0005115)2.37452877
89Abnormality of the nasal mucosa (HP:0000433)2.37412097
90Abnormal cartilage morphology (HP:0002763)2.36825383
91Gingivitis (HP:0000230)2.36685077
92Recurrent bacterial skin infections (HP:0005406)2.35641201
93Ventricular arrhythmia (HP:0004308)2.34861751
94Esophageal varix (HP:0002040)2.31659741
95Abnormality of the common coagulation pathway (HP:0010990)2.30932692
96Abnormality of the intrinsic pathway (HP:0010989)2.27977941
97Metabolic acidosis (HP:0001942)2.27891107
98Nephritis (HP:0000123)2.26641403
99Distal lower limb amyotrophy (HP:0008944)2.26539680
100Myositis (HP:0100614)2.25548127
101Abnormal atrioventricular conduction (HP:0005150)2.24387176
102Hepatocellular carcinoma (HP:0001402)2.24292291
103Abnormality of nucleobase metabolism (HP:0010932)2.23950309
104Exercise-induced myalgia (HP:0003738)2.22651879
105Myocardial infarction (HP:0001658)2.22361804
106Stroke (HP:0001297)2.22110007
107Thoracic kyphosis (HP:0002942)2.21355789
108Calf muscle hypertrophy (HP:0008981)2.20888583
109Subaortic stenosis (HP:0001682)2.20789584
110Abnormality of the left ventricular outflow tract (HP:0011103)2.20789584
111Lymphangioma (HP:0100764)2.19510443
112Increased IgE level (HP:0003212)2.19263199
113Polygenic inheritance (HP:0010982)2.19254164
114Gastrointestinal inflammation (HP:0004386)2.18867009
115Increased serum ferritin (HP:0003281)2.17913409
116Vacuolated lymphocytes (HP:0001922)2.16947926
117Joint hemorrhage (HP:0005261)2.16815456
118Amyloidosis (HP:0011034)2.15462748
119Nausea (HP:0002018)2.13726172
120Testicular atrophy (HP:0000029)2.10907368
121Pancreatic islet-cell hyperplasia (HP:0004510)2.10646715
122Abnormality of the thoracic spine (HP:0100711)2.10188701
123Polycythemia (HP:0001901)2.10153670
124Abnormality of the calf musculature (HP:0001430)2.08691942
125Fat malabsorption (HP:0002630)2.08426002
126Proximal tubulopathy (HP:0000114)2.07377905
127Abnormality of the fingertips (HP:0001211)2.06173951
128Orchitis (HP:0100796)2.05964073
129Spontaneous hematomas (HP:0007420)2.04656564
130Nasal polyposis (HP:0100582)2.03280374
131Ragged-red muscle fibers (HP:0003200)2.02949442
132Cellulitis (HP:0100658)2.02944218
133Lethargy (HP:0001254)2.00002286
134Spastic diplegia (HP:0001264)1.99833212
135Abnormality of methionine metabolism (HP:0010901)1.98614175
136Abnormality of serum amino acid levels (HP:0003112)1.98396143
137Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.98346538
138Centrally nucleated skeletal muscle fibers (HP:0003687)1.98149204
139Inflammation of the large intestine (HP:0002037)1.97414239
140Abnormality of complement system (HP:0005339)1.96281932
141Abnormality of endocrine pancreas physiology (HP:0012093)1.95744817
142Abnormality of the pancreatic islet cells (HP:0006476)1.95744817
143Interstitial pulmonary disease (HP:0006530)1.92709577
144Cervical subluxation (HP:0003308)1.91223124
145Increased purine levels (HP:0004368)1.90597827
146Hyperuricemia (HP:0002149)1.90597827
147Hyperbilirubinemia (HP:0002904)1.89876663
148Bone pain (HP:0002653)1.89865893
149Hypertriglyceridemia (HP:0002155)1.89730797
150Neonatal death (HP:0003811)1.89251791
151Aneurysm (HP:0002617)1.89165735
152Abnormality of proline metabolism (HP:0010907)1.87315977
153Hydroxyprolinuria (HP:0003080)1.87315977
154Insulin resistance (HP:0000855)1.87054983
155J-shaped sella turcica (HP:0002680)1.84915829
156Difficulty climbing stairs (HP:0003551)1.84618549
157Abdominal distention (HP:0003270)1.84532543
158Cholelithiasis (HP:0001081)1.84432720
159Easy fatigability (HP:0003388)1.84100624
160Pustule (HP:0200039)1.83862752
161Distal upper limb amyotrophy (HP:0007149)1.81395276
162Upper limb amyotrophy (HP:0009129)1.81395276
163Segmental peripheral demyelination/remyelination (HP:0003481)1.81303751
164Pathologic fracture (HP:0002756)1.80775768
165Chronic obstructive pulmonary disease (HP:0006510)1.79703475
166Obstructive lung disease (HP:0006536)1.79703475
167Mediastinal lymphadenopathy (HP:0100721)1.78452542
168Hyperacusis (HP:0010780)1.78025843
169Metaphyseal cupping (HP:0003021)1.76479964
170Nuclear cataract (HP:0100018)1.76466277
171Epistaxis (HP:0000421)1.74324212
172Bulbar palsy (HP:0001283)1.72761648
173Abnormality of iron homeostasis (HP:0011031)1.71524201
174Hypophosphatemia (HP:0002148)1.71488404
175Prolonged bleeding time (HP:0003010)1.70322952
176Diaphragmatic weakness (HP:0009113)1.68874133
177Recurrent fungal infections (HP:0002841)1.68338738
178Meningitis (HP:0001287)1.66352880
179Gastrointestinal infarctions (HP:0005244)1.65634591
180Elevated alkaline phosphatase (HP:0003155)1.63371096
181Abnormal vertebral ossification (HP:0100569)1.63293493
182Neurofibrillary tangles (HP:0002185)1.62552922
183Gingival bleeding (HP:0000225)1.60727420
184Abnormal enzyme/coenzyme activity (HP:0012379)1.60635562

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN23.83416081
2TRIB33.76672043
3TTN3.53465198
4BCKDK3.26672711
5PRPF4B2.70429832
6FGFR42.67324894
7ERN12.66002229
8SMG12.61360130
9IRAK32.51641473
10RIPK12.45977940
11MAP3K102.22036753
12SIK12.19352314
13LMTK22.02008913
14NEK11.99162613
15FLT31.95103496
16CDK121.93561663
17TAOK11.85090553
18INSRR1.71798621
19PTK61.71779167
20PDK31.67727749
21PDK41.67727749
22KDR1.61155782
23MYLK1.59947249
24PDGFRA1.51620665
25MAP3K31.49888691
26MAP3K131.48157069
27TIE11.45936560
28BLK1.43913720
29EPHA21.41797452
30RIPK41.39042555
31TNK21.36340674
32TGFBR21.35750070
33MARK21.35686170
34MAP3K141.31772886
35MAP4K11.30289773
36LATS11.26357515
37MAP2K31.24418410
38ICK1.21574766
39IRAK41.17648650
40DMPK1.17302427
41EEF2K1.17148493
42MAP3K11.15904072
43STK101.13261031
44TYK21.12888094
45PRKD21.11391723
46TAOK21.02355457
47STK38L1.00738990
48PDK20.99997123
49MTOR0.99375055
50PHKG20.99154329
51PHKG10.99154329
52IKBKE0.96351938
53MST1R0.94826651
54STK40.93543881
55EPHB10.93375321
56FGFR30.92181869
57CSF1R0.88873192
58MAP3K70.88121336
59BMX0.86791730
60PDPK10.85291629
61GRK60.84194174
62JAK10.83876269
63PRKAA20.83165727
64OBSCN0.82475709
65RPS6KA20.81320669
66HIPK20.81306463
67MATK0.80869582
68CDK40.80610746
69CHUK0.80471162
70MAPK110.80208849
71LRRK20.79764672
72PRKAA10.77229058
73IRAK20.77164036
74ITK0.76964362
75PRKD10.76543952
76CSK0.75988982
77CAMK1D0.75566096
78PTK20.75100790
79WNK40.74986691
80MAPK150.74981286
81DDR20.72353109
82JAK20.71933073
83NEK90.70992135
84PAK30.70203139
85FGR0.70075733
86MAP3K60.69864219
87MET0.68795617
88ZAP700.67998310
89DYRK1B0.67060053
90BTK0.67023329
91MAPK70.64453951
92IRAK10.62491283
93NME20.61672774
94CDK60.61094910
95CDC42BPA0.60834843
96KIT0.60685216
97FES0.59460352
98PAK40.58933869
99PASK0.58442619
100MAP3K80.57079633
101TAOK30.56539311
102IKBKB0.56299401
103NEK20.55909853
104SIK30.55840988
105TBK10.55804436
106JAK30.55447982
107MAPKAPK30.55403648
108TESK20.54981864
109STK240.54376453
110RPS6KC10.54167976
111RPS6KL10.54167976
112MAPK120.53148262
113PDK10.52863848
114TESK10.52480411
115MAP2K20.52399191
116RET0.52128666
117EPHA30.52076411
118TGFBR10.51217970
119MARK30.50509986
120GSK3A0.50395073
121PRKG20.50291219
122NLK0.49287297
123HCK0.47564763
124RPS6KA40.46959977
125RPS6KA60.46172213
126TTK0.44889824
127MAP3K110.42887967
128LCK0.42500262
129SIK20.42276740
130CAMK40.42069833
131MAP3K50.40754209
132STK380.40205691
133PIM10.39203681
134BRD40.38936451
135EPHB20.37334605
136FGFR10.35639389
137RPS6KA10.35297820
138RPS6KB20.35247913
139STK30.34135377
140PDGFRB0.33200245
141CAMK1G0.33078967
142LYN0.32879066
143PRKACG0.31142959

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.55965855
2Other glycan degradation_Homo sapiens_hsa005113.30809651
3Fatty acid degradation_Homo sapiens_hsa000713.25499159
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.13805500
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.99840628
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.83180825
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.76646398
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.66094095
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.65056927
10Propanoate metabolism_Homo sapiens_hsa006402.64007792
11Tryptophan metabolism_Homo sapiens_hsa003802.61750953
12Nitrogen metabolism_Homo sapiens_hsa009102.40702146
13Arginine biosynthesis_Homo sapiens_hsa002202.39357907
14Fatty acid metabolism_Homo sapiens_hsa012122.23540060
15Butanoate metabolism_Homo sapiens_hsa006502.06173800
16PPAR signaling pathway_Homo sapiens_hsa033201.98980322
17Carbon metabolism_Homo sapiens_hsa012001.96689021
18Pyruvate metabolism_Homo sapiens_hsa006201.81996723
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.77679810
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.73312232
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.71087302
22Complement and coagulation cascades_Homo sapiens_hsa046101.69144223
23Selenocompound metabolism_Homo sapiens_hsa004501.68350989
24Lysine degradation_Homo sapiens_hsa003101.65066882
25Osteoclast differentiation_Homo sapiens_hsa043801.64255777
26Peroxisome_Homo sapiens_hsa041461.63558775
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.62112990
28beta-Alanine metabolism_Homo sapiens_hsa004101.62102682
29Leishmaniasis_Homo sapiens_hsa051401.58295237
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.56940268
31Fat digestion and absorption_Homo sapiens_hsa049751.48827795
32Starch and sucrose metabolism_Homo sapiens_hsa005001.47966865
33Caffeine metabolism_Homo sapiens_hsa002321.47101548
34Biosynthesis of amino acids_Homo sapiens_hsa012301.44904151
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.34787157
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.32602056
37Bile secretion_Homo sapiens_hsa049761.32357173
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.31281623
39Lysosome_Homo sapiens_hsa041421.31221548
40Toll-like receptor signaling pathway_Homo sapiens_hsa046201.28902022
41Phenylalanine metabolism_Homo sapiens_hsa003601.26724982
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.23952610
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.23225333
44Histidine metabolism_Homo sapiens_hsa003401.21227544
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.19419978
46Chemical carcinogenesis_Homo sapiens_hsa052041.18356464
47B cell receptor signaling pathway_Homo sapiens_hsa046621.18347906
48Folate biosynthesis_Homo sapiens_hsa007901.17822258
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.17617811
50Hepatitis C_Homo sapiens_hsa051601.16026969
51Toxoplasmosis_Homo sapiens_hsa051451.15628609
52Staphylococcus aureus infection_Homo sapiens_hsa051501.11195716
53Tyrosine metabolism_Homo sapiens_hsa003501.09637360
54Chronic myeloid leukemia_Homo sapiens_hsa052201.09437079
55ABC transporters_Homo sapiens_hsa020101.09066932
56TNF signaling pathway_Homo sapiens_hsa046681.08214864
57Pertussis_Homo sapiens_hsa051331.06742676
58NF-kappa B signaling pathway_Homo sapiens_hsa040641.05693206
59Allograft rejection_Homo sapiens_hsa053301.05642507
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05128544
61Influenza A_Homo sapiens_hsa051641.04866500
62Tuberculosis_Homo sapiens_hsa051521.04653717
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01147071
64Cysteine and methionine metabolism_Homo sapiens_hsa002701.00373594
65Insulin resistance_Homo sapiens_hsa049310.99747971
66Arginine and proline metabolism_Homo sapiens_hsa003300.99163004
67Graft-versus-host disease_Homo sapiens_hsa053320.95984467
68Autoimmune thyroid disease_Homo sapiens_hsa053200.93875032
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91162149
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.90875953
71Amoebiasis_Homo sapiens_hsa051460.90249200
72VEGF signaling pathway_Homo sapiens_hsa043700.89944371
73Sulfur metabolism_Homo sapiens_hsa009200.89373940
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89089426
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87968717
76Retinol metabolism_Homo sapiens_hsa008300.87877561
77Fatty acid elongation_Homo sapiens_hsa000620.87320748
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83045547
79Pancreatic cancer_Homo sapiens_hsa052120.80092308
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79957294
81Galactose metabolism_Homo sapiens_hsa000520.79924095
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.78898075
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77615909
84Glycerolipid metabolism_Homo sapiens_hsa005610.76895886
85Dilated cardiomyopathy_Homo sapiens_hsa054140.76079183
86Vitamin digestion and absorption_Homo sapiens_hsa049770.75829606
87Renin-angiotensin system_Homo sapiens_hsa046140.74464091
88Fructose and mannose metabolism_Homo sapiens_hsa000510.74361564
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73250127
90Antigen processing and presentation_Homo sapiens_hsa046120.73010329
91One carbon pool by folate_Homo sapiens_hsa006700.71805649
92Malaria_Homo sapiens_hsa051440.71594348
93Non-small cell lung cancer_Homo sapiens_hsa052230.71530786
94Bladder cancer_Homo sapiens_hsa052190.71474363
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71389147
96Asthma_Homo sapiens_hsa053100.70916208
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70379669
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.69950862
99Chemokine signaling pathway_Homo sapiens_hsa040620.69718368
100Sulfur relay system_Homo sapiens_hsa041220.69627788
101Cyanoamino acid metabolism_Homo sapiens_hsa004600.67778790
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64975543
103Herpes simplex infection_Homo sapiens_hsa051680.64248303
104Salmonella infection_Homo sapiens_hsa051320.63945575
105Apoptosis_Homo sapiens_hsa042100.61938329
106Hepatitis B_Homo sapiens_hsa051610.60706851
107Viral myocarditis_Homo sapiens_hsa054160.60598265
108T cell receptor signaling pathway_Homo sapiens_hsa046600.60443408
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.59655644
110Pentose phosphate pathway_Homo sapiens_hsa000300.59559291
111Endometrial cancer_Homo sapiens_hsa052130.59243798
112Renal cell carcinoma_Homo sapiens_hsa052110.58403769
113Hematopoietic cell lineage_Homo sapiens_hsa046400.58228042
114Prolactin signaling pathway_Homo sapiens_hsa049170.57578794
115Platelet activation_Homo sapiens_hsa046110.57379455
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56883051
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56450014
118Measles_Homo sapiens_hsa051620.55552979
119Glucagon signaling pathway_Homo sapiens_hsa049220.53967301
120Glutathione metabolism_Homo sapiens_hsa004800.53706595
121AMPK signaling pathway_Homo sapiens_hsa041520.52803593
122Arachidonic acid metabolism_Homo sapiens_hsa005900.52669111
123GnRH signaling pathway_Homo sapiens_hsa049120.52210069
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.51932264
125African trypanosomiasis_Homo sapiens_hsa051430.51783167
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51688137
127Choline metabolism in cancer_Homo sapiens_hsa052310.51665815
128Sphingolipid metabolism_Homo sapiens_hsa006000.51027934
129Legionellosis_Homo sapiens_hsa051340.50961731
130Insulin signaling pathway_Homo sapiens_hsa049100.47272381
131Fatty acid biosynthesis_Homo sapiens_hsa000610.45877481
132Adherens junction_Homo sapiens_hsa045200.40366692
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.32678259
134Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32282557
135Metabolic pathways_Homo sapiens_hsa011000.31248724
136Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30511677
137Cardiac muscle contraction_Homo sapiens_hsa042600.28036314
138Notch signaling pathway_Homo sapiens_hsa043300.25978588
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25379287
140Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25290102
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24414379
142mTOR signaling pathway_Homo sapiens_hsa041500.22184009
143Carbohydrate digestion and absorption_Homo sapiens_hsa049730.20050806
144Vitamin B6 metabolism_Homo sapiens_hsa007500.19595624
145Small cell lung cancer_Homo sapiens_hsa052220.19584940
146Type II diabetes mellitus_Homo sapiens_hsa049300.18971911
147Focal adhesion_Homo sapiens_hsa045100.17051029
148Leukocyte transendothelial migration_Homo sapiens_hsa046700.16541192
149Thyroid hormone signaling pathway_Homo sapiens_hsa049190.12821366
150Prion diseases_Homo sapiens_hsa050200.12737623
151alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.12334440
152Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.11462948
153Acute myeloid leukemia_Homo sapiens_hsa052210.10702685
154Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.09006994
155Glycerophospholipid metabolism_Homo sapiens_hsa005640.08065816
156Protein digestion and absorption_Homo sapiens_hsa049740.07935591
157Tight junction_Homo sapiens_hsa045300.06886638

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