SLC12A8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is thought to be a candidate for psoriasis susceptibility. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal cholesterol absorption (GO:0030299)4.96619633
2water-soluble vitamin biosynthetic process (GO:0042364)4.88103366
3limb bud formation (GO:0060174)4.33874099
4lung lobe morphogenesis (GO:0060463)4.28454402
5negative regulation of keratinocyte proliferation (GO:0010839)4.15924557
6GDP-mannose metabolic process (GO:0019673)4.03486602
7CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.00978596
8DNA integration (GO:0015074)3.98780686
9DNA strand renaturation (GO:0000733)3.96894755
10prostate gland growth (GO:0060736)3.95764834
11proline biosynthetic process (GO:0006561)3.92570596
12digestion (GO:0007586)3.92550101
13replication fork processing (GO:0031297)3.89253645
14sulfate transport (GO:0008272)3.88898893
15tryptophan catabolic process (GO:0006569)3.86694762
16indole-containing compound catabolic process (GO:0042436)3.86694762
17indolalkylamine catabolic process (GO:0046218)3.86694762
18somite development (GO:0061053)3.84090107
19sulfate transmembrane transport (GO:1902358)3.82493277
20regulation of nuclear cell cycle DNA replication (GO:0033262)3.74625422
21kynurenine metabolic process (GO:0070189)3.66484720
22negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.65041288
23cellular ketone body metabolic process (GO:0046950)3.64726231
24maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.63469983
25meiotic chromosome segregation (GO:0045132)3.62699839
26tryptophan metabolic process (GO:0006568)3.61296231
27behavioral response to nicotine (GO:0035095)3.59082292
28platelet dense granule organization (GO:0060155)3.58113091
29indolalkylamine metabolic process (GO:0006586)3.53234080
30centriole assembly (GO:0098534)3.47688869
31nucleoside diphosphate catabolic process (GO:0009134)3.44677952
32poly(A)+ mRNA export from nucleus (GO:0016973)3.42668878
33embryonic foregut morphogenesis (GO:0048617)3.41338221
34positive regulation of prostaglandin secretion (GO:0032308)3.40885070
35replicative senescence (GO:0090399)3.40063558
36negative regulation of axon guidance (GO:1902668)3.39940413
37intestinal epithelial cell development (GO:0060576)3.38662990
38DNA deamination (GO:0045006)3.36811890
39artery development (GO:0060840)3.35715737
40regulation of mesoderm development (GO:2000380)3.33886097
41cell proliferation involved in metanephros development (GO:0072203)3.26683892
42intestinal absorption (GO:0050892)3.24551121
43single strand break repair (GO:0000012)3.21083471
44ketone body metabolic process (GO:1902224)3.18054612
45thalamus development (GO:0021794)3.15258332
46regulation of mesenchymal cell apoptotic process (GO:2001053)3.12158690
47adenosine metabolic process (GO:0046085)3.11138162
48negative regulation of mast cell activation (GO:0033004)3.08318865
49positive regulation of oligodendrocyte differentiation (GO:0048714)3.06966156
50regulation of hippo signaling (GO:0035330)3.02287687
51proline metabolic process (GO:0006560)3.02037508
52regulation of meiosis I (GO:0060631)3.00612235
53exocrine pancreas development (GO:0031017)3.00455489
54detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.96590765
55T cell lineage commitment (GO:0002360)2.96385322
56response to pheromone (GO:0019236)2.95573151
57regulation of prostaglandin secretion (GO:0032306)2.95413767
58tRNA methylation (GO:0030488)2.94255263
59pyrimidine nucleotide catabolic process (GO:0006244)2.93498634
60microtubule depolymerization (GO:0007019)2.93248500
61mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.93072055
62lung secretory cell differentiation (GO:0061140)2.92445835
63daunorubicin metabolic process (GO:0044597)2.92353311
64polyketide metabolic process (GO:0030638)2.92353311
65doxorubicin metabolic process (GO:0044598)2.92353311
66nucleotide transmembrane transport (GO:1901679)2.91387818
67respiratory chain complex IV assembly (GO:0008535)2.91326649
68DNA double-strand break processing (GO:0000729)2.90049719
69pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.88784786
70aromatic amino acid family catabolic process (GO:0009074)2.88571761
71nucleoside transmembrane transport (GO:1901642)2.86134427
72glycerophospholipid catabolic process (GO:0046475)2.85752080
73negative regulation of DNA-dependent DNA replication (GO:2000104)2.85499635
74pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.85477876
75auditory receptor cell stereocilium organization (GO:0060088)2.84667387
76somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.84040092
77isotype switching (GO:0045190)2.84040092
78somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.84040092
79kinetochore assembly (GO:0051382)2.83187768
80positive regulation of meiosis (GO:0045836)2.82113846
81protein complex biogenesis (GO:0070271)2.80991598
82female gonad development (GO:0008585)2.79751223
83DNA demethylation (GO:0080111)2.78353883
84regulation of glucokinase activity (GO:0033131)2.77879563
85regulation of hexokinase activity (GO:1903299)2.77879563
86transcription from mitochondrial promoter (GO:0006390)2.77617933
87regulation of acrosome reaction (GO:0060046)2.77567660
88pancreas development (GO:0031016)2.76971947
89lung-associated mesenchyme development (GO:0060484)2.76423615
90lactate metabolic process (GO:0006089)2.76242094
91regulation of keratinocyte proliferation (GO:0010837)2.75355371
92signal peptide processing (GO:0006465)2.74661689
93keratinocyte development (GO:0003334)2.72766012
94cell proliferation involved in kidney development (GO:0072111)2.71924980
95negative regulation of telomere maintenance (GO:0032205)2.71881129
96motile cilium assembly (GO:0044458)2.71836359
97hindbrain development (GO:0030902)2.69811467
98notochord development (GO:0030903)2.69167133
99anterograde synaptic vesicle transport (GO:0048490)2.68451371
100pseudouridine synthesis (GO:0001522)2.67367177
101mesenchymal cell proliferation (GO:0010463)2.66886741
102ATP synthesis coupled proton transport (GO:0015986)2.65404992
103energy coupled proton transport, down electrochemical gradient (GO:0015985)2.65404992
104indole-containing compound metabolic process (GO:0042430)2.64972913
105regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.64340332
106regulation of mitotic spindle checkpoint (GO:1903504)2.64340332
107regulation of gene silencing by RNA (GO:0060966)2.64049902
108regulation of posttranscriptional gene silencing (GO:0060147)2.64049902
109regulation of gene silencing by miRNA (GO:0060964)2.64049902
110regulation of double-strand break repair via homologous recombination (GO:0010569)2.63970498
111positive regulation of DNA-dependent DNA replication (GO:2000105)2.63592103
112positive regulation of meiotic cell cycle (GO:0051446)2.63222743
113organic cation transport (GO:0015695)2.62955803
114mitochondrial respiratory chain complex assembly (GO:0033108)2.62410357
115proteasome assembly (GO:0043248)2.62289681
116thyroid hormone metabolic process (GO:0042403)2.62249907
117viral mRNA export from host cell nucleus (GO:0046784)2.61622845
118righting reflex (GO:0060013)2.60890775
119positive regulation of fatty acid transport (GO:2000193)2.60016913
120establishment of protein localization to mitochondrial membrane (GO:0090151)2.59892003
121regulation of chemokine secretion (GO:0090196)2.57790742
122multicellular organism reproduction (GO:0032504)2.57707930
123DNA dealkylation (GO:0035510)2.57511395
124reflex (GO:0060004)2.56669427
125RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.56461849
126tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.56461849
127base-excision repair, AP site formation (GO:0006285)2.55799237
128positive regulation of gastrulation (GO:2000543)2.55721627
129spinal cord motor neuron differentiation (GO:0021522)2.55462292
130protein K6-linked ubiquitination (GO:0085020)2.55114129
131rRNA methylation (GO:0031167)2.55067434
132cytidine metabolic process (GO:0046087)2.54734444
133cytidine catabolic process (GO:0006216)2.54734444
134cytidine deamination (GO:0009972)2.54734444
135basic amino acid transport (GO:0015802)2.53836757
136nucleotide-sugar biosynthetic process (GO:0009226)2.52868700
137vitamin biosynthetic process (GO:0009110)2.52580316
138L-fucose catabolic process (GO:0042355)2.51723376
139fucose catabolic process (GO:0019317)2.51723376
140L-fucose metabolic process (GO:0042354)2.51723376
141cytochrome complex assembly (GO:0017004)2.51620504
142maintenance of gastrointestinal epithelium (GO:0030277)2.51612934
143positive regulation of icosanoid secretion (GO:0032305)2.51383404
144mitochondrion distribution (GO:0048311)2.51100781
145oxidative demethylation (GO:0070989)2.50787262
146dorsal/ventral neural tube patterning (GO:0021904)2.50249721
147detection of other organism (GO:0098543)2.50143098
148DNA ligation (GO:0006266)2.49804538
149membrane lipid catabolic process (GO:0046466)2.49627760
150benzene-containing compound metabolic process (GO:0042537)2.49229275
151embryonic digestive tract morphogenesis (GO:0048557)2.48956012
152mismatch repair (GO:0006298)2.48126857
153detection of bacterium (GO:0016045)2.47864541
154cornea development in camera-type eye (GO:0061303)2.47780535
155dentate gyrus development (GO:0021542)2.47773164
156centriole replication (GO:0007099)2.47514547
157mitochondrial respiratory chain complex I assembly (GO:0032981)2.47156527
158NADH dehydrogenase complex assembly (GO:0010257)2.47156527
159mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.47156527
160DNA damage response, signal transduction resulting in transcription (GO:0042772)2.46174811
161piRNA metabolic process (GO:0034587)2.45847455
162regulation of timing of cell differentiation (GO:0048505)2.44078911
163kidney morphogenesis (GO:0060993)2.44002497
164inner ear receptor stereocilium organization (GO:0060122)2.43467052
165negative regulation of myoblast differentiation (GO:0045662)2.42554169
166cobalamin metabolic process (GO:0009235)2.41503735
167startle response (GO:0001964)2.40809532
168photoreceptor cell maintenance (GO:0045494)2.40253398
169telomere maintenance via telomerase (GO:0007004)2.39900412
170rRNA modification (GO:0000154)2.39557254
171intraciliary transport (GO:0042073)2.38958079
172inner ear receptor cell differentiation (GO:0060113)2.38358398
173positive regulation of interleukin-1 beta secretion (GO:0050718)2.38253706
174epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.37596282
175DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.36449520
176histone H3-K4 trimethylation (GO:0080182)2.35083365
177mesenchymal cell differentiation involved in kidney development (GO:0072161)2.34760355
178mesenchymal cell differentiation involved in renal system development (GO:2001012)2.34760355
179somatic hypermutation of immunoglobulin genes (GO:0016446)2.33787925
180somatic diversification of immune receptors via somatic mutation (GO:0002566)2.33787925
181regulation of helicase activity (GO:0051095)2.32345828
182androgen biosynthetic process (GO:0006702)2.31866198
183intra-S DNA damage checkpoint (GO:0031573)2.31803745
184DNA catabolic process, exonucleolytic (GO:0000738)2.31224547
185DNA methylation involved in gamete generation (GO:0043046)2.31075518
186regulation of development, heterochronic (GO:0040034)2.29112876
187ceramide catabolic process (GO:0046514)2.28253227

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.93487714
2GBX2_23144817_ChIP-Seq_PC3_Human3.70767034
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.66762080
4ZNF274_21170338_ChIP-Seq_K562_Hela3.22682985
5TP63_19390658_ChIP-ChIP_HaCaT_Human2.88650695
6PCGF2_27294783_Chip-Seq_ESCs_Mouse2.73760659
7BMI1_23680149_ChIP-Seq_NPCS_Mouse2.56721263
8VDR_22108803_ChIP-Seq_LS180_Human2.54679805
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.48389630
10PCGF2_27294783_Chip-Seq_NPCs_Mouse2.46069471
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.45195585
12* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38603447
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.33506713
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.33506713
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.33506713
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31927543
17SUZ12_27294783_Chip-Seq_NPCs_Mouse2.30252277
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.24919971
19NFE2_27457419_Chip-Seq_LIVER_Mouse2.22964870
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.17801051
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15366921
22IRF1_19129219_ChIP-ChIP_H3396_Human2.14526814
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.04636405
24POU5F1_16153702_ChIP-ChIP_HESCs_Human2.01198697
25E2F7_22180533_ChIP-Seq_HELA_Human2.00044198
26STAT3_18555785_Chip-Seq_ESCs_Mouse1.93679490
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.93300287
28* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90123553
29SUZ12_18555785_Chip-Seq_ESCs_Mouse1.86416953
30ELK1_19687146_ChIP-ChIP_HELA_Human1.82620375
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82024929
32RNF2_27304074_Chip-Seq_NSC_Mouse1.81220805
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.81022727
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.79050717
35EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.78856905
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76484910
37BCAT_22108803_ChIP-Seq_LS180_Human1.76288611
38TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.75454106
39EGR1_23403033_ChIP-Seq_LIVER_Mouse1.74115864
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.74013471
41E2F1_18555785_Chip-Seq_ESCs_Mouse1.72981447
42RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.71985018
43* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71553299
44NMYC_18555785_Chip-Seq_ESCs_Mouse1.69541897
45ZFX_18555785_Chip-Seq_ESCs_Mouse1.69541220
46NANOG_18555785_Chip-Seq_ESCs_Mouse1.68373467
47ESRRB_18555785_Chip-Seq_ESCs_Mouse1.63944092
48P53_22387025_ChIP-Seq_ESCs_Mouse1.63398822
49OCT4_18555785_Chip-Seq_ESCs_Mouse1.60884241
50SOX2_18555785_Chip-Seq_ESCs_Mouse1.59449180
51KLF4_18555785_Chip-Seq_ESCs_Mouse1.59202561
52P300_18555785_Chip-Seq_ESCs_Mouse1.58457334
53CMYC_18555785_Chip-Seq_ESCs_Mouse1.57180500
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56724792
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56724153
56EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.55504898
57* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55480225
58RUNX1_27457419_Chip-Seq_LIVER_Mouse1.54439863
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54153287
60FUS_26573619_Chip-Seq_HEK293_Human1.52662217
61ER_23166858_ChIP-Seq_MCF-7_Human1.49362132
62EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.49124461
63NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.48912037
64NANOG_19829295_ChIP-Seq_ESCs_Human1.47094422
65SOX2_19829295_ChIP-Seq_ESCs_Human1.47094422
66IRF8_22096565_ChIP-ChIP_GC-B_Human1.43986222
67MYC_18940864_ChIP-ChIP_HL60_Human1.43666837
68CTCF_18555785_Chip-Seq_ESCs_Mouse1.43665967
69SMAD1_18555785_Chip-Seq_ESCs_Mouse1.43550941
70AR_25329375_ChIP-Seq_VCAP_Human1.43117707
71CDX2_20551321_ChIP-Seq_CACO-2_Human1.42320723
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41412236
73KAP1_22055183_ChIP-Seq_ESCs_Mouse1.40915602
74PU1_27457419_Chip-Seq_LIVER_Mouse1.38600964
75TAL1_26923725_Chip-Seq_HPCs_Mouse1.37490057
76P300_19829295_ChIP-Seq_ESCs_Human1.34793378
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.31290424
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.28507912
79TP53_22573176_ChIP-Seq_HFKS_Human1.28351620
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28024093
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27894568
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26285698
83TCF4_22108803_ChIP-Seq_LS180_Human1.25575861
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.25237633
85EWS_26573619_Chip-Seq_HEK293_Human1.25136348
86FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24208596
87FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23977306
88FOXA1_25329375_ChIP-Seq_VCAP_Human1.23977306
89VDR_23849224_ChIP-Seq_CD4+_Human1.22689470
90EZH2_22144423_ChIP-Seq_EOC_Human1.22384211
91ELF1_17652178_ChIP-ChIP_JURKAT_Human1.22288563
92CDX2_22108803_ChIP-Seq_LS180_Human1.21337855
93FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21144081
94KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.20925641
95CBP_20019798_ChIP-Seq_JUKART_Human1.20177103
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20177103
97CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.16972498
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16852716
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16852716
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15440831
101CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15423603
102P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15222796
103SMAD4_21741376_ChIP-Seq_EPCs_Human1.15193328
104SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14714453
105SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.14294424
106* AR_20517297_ChIP-Seq_VCAP_Human1.12969606
107YY1_21170310_ChIP-Seq_MESCs_Mouse1.12634219
108SMAD_19615063_ChIP-ChIP_OVARY_Human1.11930506
109CRX_20693478_ChIP-Seq_RETINA_Mouse1.11922404
110AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10726507
111OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10106580
112NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.09615122
113POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09395200
114SRF_21415370_ChIP-Seq_HL-1_Mouse1.09337417
115RUNX2_22187159_ChIP-Seq_PCA_Human1.09252363
116HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09224641
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08620030
118CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07616827
119PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04777256
120OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04424087
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04330630
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02180847
123TCF3_18692474_ChIP-Seq_MESCs_Mouse1.01779328
124SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00758332
125PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99969010
126IGF1R_20145208_ChIP-Seq_DFB_Human0.98662637
127PIAS1_25552417_ChIP-Seq_VCAP_Human0.98521694
128HOXB7_26014856_ChIP-Seq_BT474_Human0.97888869
129PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97874162
130CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97394354
131FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97121151
132* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96878076
133NCOR_22424771_ChIP-Seq_293T_Human0.96310436
134CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95576164
135ETS1_20019798_ChIP-Seq_JURKAT_Human0.95098800
136AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94748399
137SMAD4_21799915_ChIP-Seq_A2780_Human0.94565035
138KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93884055
139LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91190354
140JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.90968513
141TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90887743
142* STAT3_23295773_ChIP-Seq_U87_Human0.90673273
143PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.89010921
144TAF15_26573619_Chip-Seq_HEK293_Human0.88964877
145HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.87731704
146STAT3_18555785_ChIP-Seq_MESCs_Mouse0.86718460
147* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85639255
148TCF4_23295773_ChIP-Seq_U87_Human0.83990757
149ETV1_20927104_ChIP-Seq_GIST48_Human0.83443419

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ5.88704193
2MP0006292_abnormal_olfactory_placode4.51326468
3MP0001188_hyperpigmentation3.38473910
4MP0002277_abnormal_respiratory_mucosa3.36426510
5MP0003195_calcinosis3.34617442
6MP0000566_synostosis3.33485581
7MP0002234_abnormal_pharynx_morphology2.97172985
8MP0000383_abnormal_hair_follicle2.80624494
9MP0008058_abnormal_DNA_repair2.76081961
10MP0005171_absent_coat_pigmentation2.63003070
11MP0008057_abnormal_DNA_replication2.57019026
12MP0010678_abnormal_skin_adnexa2.43312004
13MP0001666_abnormal_nutrient_absorption2.38826398
14MP0000490_abnormal_crypts_of2.34160489
15MP0003136_yellow_coat_color2.32995640
16MP0000015_abnormal_ear_pigmentation2.31387434
17MP0002102_abnormal_ear_morphology2.23969675
18MP0008789_abnormal_olfactory_epithelium2.16102349
19MP0002254_reproductive_system_inflammat2.12961443
20MP0002138_abnormal_hepatobiliary_system2.10061740
21MP0005394_taste/olfaction_phenotype1.99284509
22MP0005499_abnormal_olfactory_system1.99284509
23MP0002132_abnormal_respiratory_system1.94608134
24MP0002837_dystrophic_cardiac_calcinosis1.90875037
25MP0008875_abnormal_xenobiotic_pharmacok1.85477087
26MP0004264_abnormal_extraembryonic_tissu1.83956359
27MP0005075_abnormal_melanosome_morpholog1.79290374
28MP0005646_abnormal_pituitary_gland1.79099167
29MP0003787_abnormal_imprinting1.79051315
30MP0010094_abnormal_chromosome_stability1.76571422
31MP0002009_preneoplasia1.74081475
32MP0003693_abnormal_embryo_hatching1.71174293
33MP0002282_abnormal_trachea_morphology1.70715719
34MP0008872_abnormal_physiological_respon1.68121210
35MP0000427_abnormal_hair_cycle1.60841784
36MP0002249_abnormal_larynx_morphology1.60090996
37MP0000569_abnormal_digit_pigmentation1.57103568
38MP0001664_abnormal_digestion1.53735792
39MP0003941_abnormal_skin_development1.52943824
40MP0003718_maternal_effect1.51859402
41MP0009046_muscle_twitch1.51091655
42MP0003111_abnormal_nucleus_morphology1.50305816
43MP0003011_delayed_dark_adaptation1.49587346
44MP0005084_abnormal_gallbladder_morpholo1.47739843
45MP0008877_abnormal_DNA_methylation1.45400849
46MP0000470_abnormal_stomach_morphology1.45174886
47MP0005645_abnormal_hypothalamus_physiol1.44717005
48MP0002876_abnormal_thyroid_physiology1.44488288
49MP0005332_abnormal_amino_acid1.44406587
50MP0000678_abnormal_parathyroid_gland1.44156006
51MP0002938_white_spotting1.38463120
52MP0001873_stomach_inflammation1.37485747
53MP0005174_abnormal_tail_pigmentation1.36526083
54MP0008260_abnormal_autophagy1.36412786
55MP0003868_abnormal_feces_composition1.35320803
56MP0000049_abnormal_middle_ear1.35183496
57MP0010030_abnormal_orbit_morphology1.34499583
58MP0010386_abnormal_urinary_bladder1.32249071
59MP0005220_abnormal_exocrine_pancreas1.31971357
60MP0009053_abnormal_anal_canal1.31640780
61MP0005377_hearing/vestibular/ear_phenot1.30395229
62MP0003878_abnormal_ear_physiology1.30395229
63MP0003183_abnormal_peptide_metabolism1.29306425
64MP0003786_premature_aging1.26702236
65MP0010155_abnormal_intestine_physiology1.26642985
66MP0005085_abnormal_gallbladder_physiolo1.26525616
67MP0002909_abnormal_adrenal_gland1.26305830
68MP0008995_early_reproductive_senescence1.25755424
69MP0000685_abnormal_immune_system1.25635214
70MP0003890_abnormal_embryonic-extraembry1.24388377
71MP0002163_abnormal_gland_morphology1.23909949
72MP0005551_abnormal_eye_electrophysiolog1.23544417
73MP0004019_abnormal_vitamin_homeostasis1.22844323
74MP0000026_abnormal_inner_ear1.22393694
75MP0000462_abnormal_digestive_system1.22002392
76MP0009697_abnormal_copulation1.21463155
77MP0005360_urolithiasis1.17973816
78MP0001944_abnormal_pancreas_morphology1.15165115
79MP0004782_abnormal_surfactant_physiolog1.13882280
80MP0008004_abnormal_stomach_pH1.13254176
81MP0005395_other_phenotype1.13090816
82MP0006072_abnormal_retinal_apoptosis1.12598966
83MP0001986_abnormal_taste_sensitivity1.11826502
84MP0002693_abnormal_pancreas_physiology1.10490805
85MP0005253_abnormal_eye_physiology1.08719446
86MP0003119_abnormal_digestive_system1.07586350
87MP0004147_increased_porphyrin_level1.07520281
88MP0005409_darkened_coat_color1.07143329
89MP0001663_abnormal_digestive_system1.06935000
90MP0001984_abnormal_olfaction1.05320050
91MP0000372_irregular_coat_pigmentation1.04398579
92MP0002139_abnormal_hepatobiliary_system1.04280680
93MP0003937_abnormal_limbs/digits/tail_de1.03919386
94MP0000538_abnormal_urinary_bladder1.02706161
95MP0001186_pigmentation_phenotype1.01835227
96MP0002233_abnormal_nose_morphology1.01744870
97MP0003045_fibrosis1.01184876
98MP0002928_abnormal_bile_duct0.98864158
99MP0003806_abnormal_nucleotide_metabolis0.98353923
100MP0002751_abnormal_autonomic_nervous0.97973111
101MP0003252_abnormal_bile_duct0.97620486
102MP0002653_abnormal_ependyma_morphology0.96974982
103MP0001293_anophthalmia0.96778255
104MP0005381_digestive/alimentary_phenotyp0.96571573
105MP0002638_abnormal_pupillary_reflex0.96106019
106MP0003866_abnormal_defecation0.95932323
107MP0010234_abnormal_vibrissa_follicle0.94322265
108MP0004043_abnormal_pH_regulation0.93489930
109MP0005367_renal/urinary_system_phenotyp0.93414343
110MP0000516_abnormal_urinary_system0.93414343
111MP0000613_abnormal_salivary_gland0.93393869
112MP0002095_abnormal_skin_pigmentation0.93052510
113MP0001119_abnormal_female_reproductive0.92665647
114MP0002736_abnormal_nociception_after0.92390380
115MP0002168_other_aberrant_phenotype0.91533668
116MP0005310_abnormal_salivary_gland0.89692961
117MP0000762_abnormal_tongue_morphology0.89537894
118MP0001501_abnormal_sleep_pattern0.89239105
119MP0005365_abnormal_bile_salt0.88830071
120MP0002210_abnormal_sex_determination0.87638370
121MP0001968_abnormal_touch/_nociception0.86864496
122MP0001963_abnormal_hearing_physiology0.86773287
123MP0004133_heterotaxia0.86101071
124MP0009745_abnormal_behavioral_response0.85619141
125MP0004145_abnormal_muscle_electrophysio0.85391480
126MP0002735_abnormal_chemical_nociception0.85244094
127MP0005389_reproductive_system_phenotype0.85207984
128MP0001764_abnormal_homeostasis0.84149014
129MP0002396_abnormal_hematopoietic_system0.84147161
130MP0000631_abnormal_neuroendocrine_gland0.84016596
131MP0002075_abnormal_coat/hair_pigmentati0.82123846
132MP0000681_abnormal_thyroid_gland0.81901285
133MP0008961_abnormal_basal_metabolism0.81816341
134MP0001286_abnormal_eye_development0.81179718
135MP0001502_abnormal_circadian_rhythm0.80448615
136MP0004885_abnormal_endolymph0.79936138
137MP0001485_abnormal_pinna_reflex0.79725716
138MP0002160_abnormal_reproductive_system0.79667897
139MP0003938_abnormal_ear_development0.78973729
140MP0005410_abnormal_fertilization0.78296407
141MP0002090_abnormal_vision0.75597512
142MP0003315_abnormal_perineum_morphology0.75386231
143MP0001324_abnormal_eye_pigmentation0.74525522
144MP0010329_abnormal_lipoprotein_level0.74424287
145MP0004742_abnormal_vestibular_system0.74234008
146MP0002098_abnormal_vibrissa_morphology0.73817992
147MP0003950_abnormal_plasma_membrane0.73217833
148MP0004381_abnormal_hair_follicle0.73126542
149MP0003755_abnormal_palate_morphology0.72614662
150MP0005195_abnormal_posterior_eye0.72500774
151MP0000371_diluted_coat_color0.71676115
152MP0004142_abnormal_muscle_tone0.71591096
153MP0005379_endocrine/exocrine_gland_phen0.71552352
154MP0003077_abnormal_cell_cycle0.70912576
155MP0001529_abnormal_vocalization0.69138265
156MP0003936_abnormal_reproductive_system0.67122920
157MP0001756_abnormal_urination0.65699325
158MP0001145_abnormal_male_reproductive0.65574291

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.36736662
2Chromsome breakage (HP:0040012)4.86457579
3Pancreatic cysts (HP:0001737)4.15097001
4Abnormality of midbrain morphology (HP:0002418)3.50214436
5Molar tooth sign on MRI (HP:0002419)3.50214436
6Bilateral microphthalmos (HP:0007633)3.49689096
7Tubular atrophy (HP:0000092)3.42333132
8Congenital stationary night blindness (HP:0007642)3.33688800
9Prostate neoplasm (HP:0100787)3.23634188
10Abnormality of the renal collecting system (HP:0004742)3.15008868
11Duplicated collecting system (HP:0000081)3.07081832
12Optic nerve hypoplasia (HP:0000609)2.98752433
13Congenital, generalized hypertrichosis (HP:0004540)2.98105594
14Aplasia/Hypoplasia of the fovea (HP:0008060)2.97689064
15Hypoplasia of the fovea (HP:0007750)2.97689064
16Keratoconus (HP:0000563)2.93323996
17Increased corneal curvature (HP:0100692)2.93323996
18Aplasia/Hypoplasia of the uvula (HP:0010293)2.89982178
19Congenital sensorineural hearing impairment (HP:0008527)2.89267826
20Abnormality of the preputium (HP:0100587)2.87092597
21Type I transferrin isoform profile (HP:0003642)2.83785654
22Febrile seizures (HP:0002373)2.83307918
23Intestinal atresia (HP:0011100)2.82766136
24Nephronophthisis (HP:0000090)2.79717157
25Septo-optic dysplasia (HP:0100842)2.78787031
26Attenuation of retinal blood vessels (HP:0007843)2.74311590
27Tubulointerstitial nephritis (HP:0001970)2.71712242
28Oligodactyly (hands) (HP:0001180)2.68103604
29Abnormality of the ileum (HP:0001549)2.67458190
30Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.61695020
31Cystic liver disease (HP:0006706)2.53521105
32Abnormality of the labia minora (HP:0012880)2.53417982
33Reduced antithrombin III activity (HP:0001976)2.53197756
34Abnormality of the renal medulla (HP:0100957)2.52197076
35Furrowed tongue (HP:0000221)2.49921353
36Pendular nystagmus (HP:0012043)2.47806555
37Anophthalmia (HP:0000528)2.45620518
38Meckel diverticulum (HP:0002245)2.44561990
39Bile duct proliferation (HP:0001408)2.37147431
40Abnormal biliary tract physiology (HP:0012439)2.37147431
41Cheilitis (HP:0100825)2.35749266
42Lip pit (HP:0100267)2.34540659
43Aplasia/Hypoplasia of the tongue (HP:0010295)2.32854311
44Abnormality of chromosome stability (HP:0003220)2.29822865
45Narrow nasal bridge (HP:0000446)2.29289726
463-Methylglutaconic aciduria (HP:0003535)2.28712480
47Type 2 muscle fiber atrophy (HP:0003554)2.28658645
48Large for gestational age (HP:0001520)2.27217249
49Nephroblastoma (Wilms tumor) (HP:0002667)2.26668658
50Renal cortical cysts (HP:0000803)2.25493968
51Abnormality of the fovea (HP:0000493)2.23707451
52True hermaphroditism (HP:0010459)2.21239037
53Ectopic kidney (HP:0000086)2.20800969
54Sclerocornea (HP:0000647)2.20425683
55Medial flaring of the eyebrow (HP:0010747)2.18867322
56Abnormal number of incisors (HP:0011064)2.18806797
57Optic neuritis (HP:0100653)2.18511850
58Retrobulbar optic neuritis (HP:0100654)2.18511850
59Progressive sensorineural hearing impairment (HP:0000408)2.18110706
60Abnormality of male internal genitalia (HP:0000022)2.16587052
61Osteomalacia (HP:0002749)2.16301805
62Anencephaly (HP:0002323)2.15393248
63Progressive inability to walk (HP:0002505)2.14555424
64Abnormal rod and cone electroretinograms (HP:0008323)2.12712115
65Chronic hepatic failure (HP:0100626)2.12692852
66Rib fusion (HP:0000902)2.11606363
67Clubbing of toes (HP:0100760)2.11604822
68Embryonal renal neoplasm (HP:0011794)2.10594084
69Increased CSF lactate (HP:0002490)2.10011819
70Increased IgM level (HP:0003496)2.09559837
71Abnormal pancreas size (HP:0012094)2.08556725
72Abnormal respiratory epithelium morphology (HP:0012253)2.08238974
73Abnormal respiratory motile cilium morphology (HP:0005938)2.08238974
74Decreased electroretinogram (ERG) amplitude (HP:0000654)2.08124660
75Severe visual impairment (HP:0001141)2.07832149
76Inability to walk (HP:0002540)2.07628613
77Small intestinal stenosis (HP:0012848)2.07557032
78Duodenal stenosis (HP:0100867)2.07557032
79Tubulointerstitial fibrosis (HP:0005576)2.06710235
80Nephrogenic diabetes insipidus (HP:0009806)2.06101622
81Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.05346822
82Abnormal protein N-linked glycosylation (HP:0012347)2.05346822
83Abnormal protein glycosylation (HP:0012346)2.05346822
84Abnormal glycosylation (HP:0012345)2.05346822
85Abnormality of DNA repair (HP:0003254)2.05013884
86Mitochondrial inheritance (HP:0001427)2.04945206
87Type II lissencephaly (HP:0007260)2.04763939
88Acute necrotizing encephalopathy (HP:0006965)2.04239870
89Hypoplasia of the pons (HP:0012110)2.02395574
90Abnormality of macular pigmentation (HP:0008002)2.00911957
91Flat capital femoral epiphysis (HP:0003370)2.00832085
92Median cleft lip (HP:0000161)1.99960547
93Colon cancer (HP:0003003)1.99586212
94Sex reversal (HP:0012245)1.99562459
95Abnormal sex determination (HP:0012244)1.99562459
96Aplasia cutis congenita (HP:0001057)1.99012093
97Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.98579518
98Upper limb muscle weakness (HP:0003484)1.97543513
99Congenital primary aphakia (HP:0007707)1.94317022
100Hyperventilation (HP:0002883)1.92099951
101Polydipsia (HP:0001959)1.90820986
102Abnormal drinking behavior (HP:0030082)1.90820986
103Long foot (HP:0001833)1.90740567
104Progressive macrocephaly (HP:0004481)1.90725008
105Optic disc pallor (HP:0000543)1.90021992
106Abolished electroretinogram (ERG) (HP:0000550)1.89608203
107Decreased central vision (HP:0007663)1.89433303
108Birth length less than 3rd percentile (HP:0003561)1.88881953
109IgA deficiency (HP:0002720)1.88729026
110Chronic diarrhea (HP:0002028)1.88344411
111Acute encephalopathy (HP:0006846)1.88122646
112Neoplasm of the adrenal cortex (HP:0100641)1.88083766
113Aplasia/Hypoplasia of the tibia (HP:0005772)1.87347662
114Tented upper lip vermilion (HP:0010804)1.87266323
115Absent radius (HP:0003974)1.86073961
116Glycosuria (HP:0003076)1.85230953
117Abnormality of urine glucose concentration (HP:0011016)1.85230953
118Central scotoma (HP:0000603)1.85205983
119Hypergonadotropic hypogonadism (HP:0000815)1.85154278
120Methylmalonic acidemia (HP:0002912)1.84971043
121Lissencephaly (HP:0001339)1.84932502
122Impulsivity (HP:0100710)1.84654080
123Pancreatic fibrosis (HP:0100732)1.84445742
124Gait imbalance (HP:0002141)1.84322655
125Gastrointestinal atresia (HP:0002589)1.83391320
126Hepatic necrosis (HP:0002605)1.82544904
127Labial hypoplasia (HP:0000066)1.82336398
128Abnormal ciliary motility (HP:0012262)1.81714018
129Dandy-Walker malformation (HP:0001305)1.80858130
130Increased serum lactate (HP:0002151)1.80355740
131Patellar aplasia (HP:0006443)1.79226783
132Recurrent sinusitis (HP:0011108)1.79064293
133Hypoalbuminemia (HP:0003073)1.78406610
134Abnormal albumin level (HP:0012116)1.78406610
135Male pseudohermaphroditism (HP:0000037)1.78094277
136Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.77804178
137Tubulointerstitial abnormality (HP:0001969)1.77454887
138Poor head control (HP:0002421)1.77065102
139Congenital hepatic fibrosis (HP:0002612)1.76631042
140Intestinal fistula (HP:0100819)1.76125638
141Abnormality of aspartate family amino acid metabolism (HP:0010899)1.76115123
142Ketosis (HP:0001946)1.76051730
143Gaze-evoked nystagmus (HP:0000640)1.75109472
144Amelogenesis imperfecta (HP:0000705)1.74975860
145Methylmalonic aciduria (HP:0012120)1.74362087
146Abnormality of vitamin B metabolism (HP:0004340)1.74358259
147Poor coordination (HP:0002370)1.73591891
148Abnormality of the pons (HP:0007361)1.72196657
149Absent septum pellucidum (HP:0001331)1.72081217
150Rectal fistula (HP:0100590)1.71752401
151Rectovaginal fistula (HP:0000143)1.71752401
152Dynein arm defect of respiratory motile cilia (HP:0012255)1.71336271
153Absent/shortened dynein arms (HP:0200106)1.71336271
154Lipid accumulation in hepatocytes (HP:0006561)1.71067909
155Abnormality of the prostate (HP:0008775)1.70479688
156Abnormality of the renal cortex (HP:0011035)1.70176425
157Bifid uvula (HP:0000193)1.69684099
158Hepatocellular necrosis (HP:0001404)1.69263829
159Abnormality of the carotid arteries (HP:0005344)1.68711683
160Absent forearm bone (HP:0003953)1.68678996
161Aplasia involving forearm bones (HP:0009822)1.68678996
162Abnormality of the duodenum (HP:0002246)1.68541298
163White forelock (HP:0002211)1.68348571
164Ketoacidosis (HP:0001993)1.67963624
165Preaxial hand polydactyly (HP:0001177)1.67356263
166Abnormality of incisor morphology (HP:0011063)1.66482283
167Postaxial foot polydactyly (HP:0001830)1.66122291
168Hypoplastic female external genitalia (HP:0012815)1.66052112
169Fair hair (HP:0002286)1.66023128
170Oligohydramnios (HP:0001562)1.65701051
171Muscle fiber atrophy (HP:0100295)1.65220842
172Aganglionic megacolon (HP:0002251)1.64956549
173Hypothermia (HP:0002045)1.64771189
174Aplasia/Hypoplasia of the patella (HP:0006498)1.64495312
175Growth hormone deficiency (HP:0000824)1.64450563
176Conical tooth (HP:0000698)1.64404416

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.63220063
2ZAK3.22307098
3AKT33.00947124
4VRK22.92783135
5STK162.71479595
6YES12.67236212
7TAF12.54736586
8SIK32.50063280
9IRAK32.43321560
10INSRR2.41745676
11WNK32.39046959
12STK38L2.10524761
13GRK12.07283880
14NUAK11.99522836
15FRK1.95678798
16ACVR1B1.93846882
17TNIK1.86022231
18STK241.80373392
19TXK1.77920455
20SRPK11.72952581
21PINK11.69699306
22PRPF4B1.69036687
23MAPK151.67703414
24NEK61.67579807
25BMPR21.65570214
26STK391.62708426
27OXSR11.59962899
28EIF2AK21.57395865
29BUB11.54610133
30STK31.53573543
31NEK11.53473013
32MKNK21.52954353
33MAP2K71.49080409
34MAP3K141.46293931
35MAP3K61.44113347
36ERBB31.42070015
37ADRBK21.41923922
38TTK1.41552611
39PLK41.40374874
40NEK91.39474274
41VRK11.37726792
42PLK21.35148640
43IRAK41.34494100
44TAOK21.33659595
45CDK81.29961359
46CDK71.25547062
47CHEK21.24884263
48CDK31.18590632
49MAPK131.15679731
50PIM21.13937381
51BMPR1B1.12019951
52CSNK1G11.11148134
53TRIM281.10510611
54PASK1.09124589
55EPHA21.07743659
56BRD41.05378050
57MAP4K21.04784868
58PAK31.04646820
59MAP3K41.02596108
60MATK1.01585615
61TGFBR11.01499466
62MAPKAPK51.01057835
63CDK121.01048589
64WNK41.00784640
65MKNK10.99329275
66EIF2AK10.97722710
67TLK10.97659658
68CSNK1G30.96917314
69BLK0.93500396
70PNCK0.93073177
71PIK3CA0.92953295
72ATR0.92686468
73NME10.92662440
74TRPM70.90640848
75FGFR20.89875452
76MAPKAPK30.89854765
77LMTK20.89391154
78MUSK0.87608746
79MAP3K120.85907184
80CSNK1A1L0.84883419
81PLK10.83037936
82BRSK20.82774391
83DYRK20.81072149
84CSNK1G20.80300938
85TSSK60.80171712
86MST40.79538406
87MAP2K60.79328942
88PIM10.78418251
89PHKG10.77163069
90PHKG20.77163069
91SGK20.76822927
92EIF2AK30.76347547
93TEC0.75615452
94MAP2K20.75306377
95RPS6KB10.75123699
96WEE10.73977108
97PRKG20.73152046
98IRAK20.72542559
99BCR0.72510659
100CCNB10.70738010
101CHUK0.70528774
102TAOK30.70428843
103MAPK70.70334001
104IKBKB0.69565373
105PTK2B0.68245823
106PLK30.64867820
107TNK20.63124185
108ADRBK10.62253027
109FER0.61995295
110PRKCI0.59912571
111MELK0.59480908
112PRKCQ0.58457920
113DDR20.57947247
114PRKCG0.56728000
115DYRK30.56201174
116EPHB20.55586203
117ATM0.54981883
118BRAF0.53092001
119CDC70.52084770
120FGR0.50696270
121ERBB40.50210626
122RPS6KA50.50175836
123NEK20.46874943
124BCKDK0.46437826
125NLK0.46020061
126PRKD20.45555014
127DAPK20.44113948
128CDK90.43912942
129CSK0.43167721
130KIT0.42504730
131EPHA30.42413197
132SMG10.40028027
133DAPK30.38710712
134CDC42BPA0.38656844
135CSNK2A10.38189057
136GRK70.36787492
137PBK0.36471445
138AURKB0.36326682
139NTRK30.34613741
140LYN0.34403910
141PRKCE0.34167375
142DYRK1A0.33297945
143CSNK1A10.33184896
144RPS6KB20.31812870
145PRKAA10.31505855
146DAPK10.31223070
147PRKCD0.30478000
148MAPK30.30400717
149DMPK0.29384384
150CHEK10.29063483
151CAMK2A0.28293163
152IRAK10.28156830
153SIK20.28079312
154CAMK2B0.27210557
155CAMK2D0.27129348
156PRKACA0.26355928
157PIK3CG0.24663803
158PRKCZ0.24258343

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.13773377
2Homologous recombination_Homo sapiens_hsa034402.78531051
3Base excision repair_Homo sapiens_hsa034102.52763369
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.52416388
5Proteasome_Homo sapiens_hsa030502.28402175
6Pancreatic secretion_Homo sapiens_hsa049722.19243694
7Mismatch repair_Homo sapiens_hsa034302.18409032
8Asthma_Homo sapiens_hsa053102.15382254
9Oxidative phosphorylation_Homo sapiens_hsa001902.08234272
10Tryptophan metabolism_Homo sapiens_hsa003802.04456130
11Non-homologous end-joining_Homo sapiens_hsa034501.98829525
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.98105991
13Selenocompound metabolism_Homo sapiens_hsa004501.96380405
14Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.95348465
15DNA replication_Homo sapiens_hsa030301.93270749
16Fat digestion and absorption_Homo sapiens_hsa049751.87959033
17Butanoate metabolism_Homo sapiens_hsa006501.87577104
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.87266833
19Arachidonic acid metabolism_Homo sapiens_hsa005901.86426106
20Phototransduction_Homo sapiens_hsa047441.86112040
21Sulfur metabolism_Homo sapiens_hsa009201.80670843
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.78640595
23Type I diabetes mellitus_Homo sapiens_hsa049401.78624923
24Protein digestion and absorption_Homo sapiens_hsa049741.77857348
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.77362635
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.74768640
27Vitamin digestion and absorption_Homo sapiens_hsa049771.73735770
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.73357456
29Caffeine metabolism_Homo sapiens_hsa002321.73272973
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.73079409
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.69907546
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.67972579
33Basal transcription factors_Homo sapiens_hsa030221.60661635
34Linoleic acid metabolism_Homo sapiens_hsa005911.60231930
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.57814714
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.54750189
37RNA polymerase_Homo sapiens_hsa030201.53761403
38Mineral absorption_Homo sapiens_hsa049781.52224490
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51052496
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.50232334
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.45337999
42Propanoate metabolism_Homo sapiens_hsa006401.39709533
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.39340908
44Parkinsons disease_Homo sapiens_hsa050121.37794192
45Nucleotide excision repair_Homo sapiens_hsa034201.37591337
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37241122
47RNA degradation_Homo sapiens_hsa030181.35371501
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.31710572
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.28108790
50Pyrimidine metabolism_Homo sapiens_hsa002401.26663410
51Nicotine addiction_Homo sapiens_hsa050331.24422494
52Sphingolipid metabolism_Homo sapiens_hsa006001.23749136
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.21859567
54Circadian rhythm_Homo sapiens_hsa047101.21609179
55Ether lipid metabolism_Homo sapiens_hsa005651.15649228
56Purine metabolism_Homo sapiens_hsa002301.14993895
57Folate biosynthesis_Homo sapiens_hsa007901.14364026
58Fructose and mannose metabolism_Homo sapiens_hsa000511.14185726
59Cell cycle_Homo sapiens_hsa041101.14004127
60Chemical carcinogenesis_Homo sapiens_hsa052041.12790758
61Renin-angiotensin system_Homo sapiens_hsa046141.08215085
62Systemic lupus erythematosus_Homo sapiens_hsa053221.06400675
63Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.03820668
64Peroxisome_Homo sapiens_hsa041461.03427844
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03149845
66Taste transduction_Homo sapiens_hsa047421.02691841
67Autoimmune thyroid disease_Homo sapiens_hsa053201.01270048
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00720505
69p53 signaling pathway_Homo sapiens_hsa041150.99690352
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97967024
71Nitrogen metabolism_Homo sapiens_hsa009100.97186646
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.91980821
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91892035
74Huntingtons disease_Homo sapiens_hsa050160.90942282
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.90828675
76Hedgehog signaling pathway_Homo sapiens_hsa043400.90086941
77Other glycan degradation_Homo sapiens_hsa005110.89719869
78beta-Alanine metabolism_Homo sapiens_hsa004100.88865220
79Alzheimers disease_Homo sapiens_hsa050100.87737839
80Herpes simplex infection_Homo sapiens_hsa051680.87620942
81Protein export_Homo sapiens_hsa030600.84143711
82One carbon pool by folate_Homo sapiens_hsa006700.83859442
83mRNA surveillance pathway_Homo sapiens_hsa030150.82151577
84Primary immunodeficiency_Homo sapiens_hsa053400.81803615
85Arginine and proline metabolism_Homo sapiens_hsa003300.81136635
86Histidine metabolism_Homo sapiens_hsa003400.78657921
87Regulation of autophagy_Homo sapiens_hsa041400.77011230
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76262016
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76215965
90Spliceosome_Homo sapiens_hsa030400.74291445
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74008646
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73642865
93Hematopoietic cell lineage_Homo sapiens_hsa046400.73614921
94Influenza A_Homo sapiens_hsa051640.73611459
95ABC transporters_Homo sapiens_hsa020100.72856880
96Notch signaling pathway_Homo sapiens_hsa043300.71074793
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69642421
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69357260
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68075210
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.67079651
101RNA transport_Homo sapiens_hsa030130.66245126
102Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65895055
103Galactose metabolism_Homo sapiens_hsa000520.65526154
104Measles_Homo sapiens_hsa051620.64856659
105Allograft rejection_Homo sapiens_hsa053300.63779005
106Steroid biosynthesis_Homo sapiens_hsa001000.62545604
107N-Glycan biosynthesis_Homo sapiens_hsa005100.60752171
108Ovarian steroidogenesis_Homo sapiens_hsa049130.57114664
109Fatty acid degradation_Homo sapiens_hsa000710.56150624
110Graft-versus-host disease_Homo sapiens_hsa053320.55889855
111Fatty acid elongation_Homo sapiens_hsa000620.55617021
112Serotonergic synapse_Homo sapiens_hsa047260.54451276
113Vitamin B6 metabolism_Homo sapiens_hsa007500.54225110
114Pyruvate metabolism_Homo sapiens_hsa006200.53485696
115Glutathione metabolism_Homo sapiens_hsa004800.52401425
116Legionellosis_Homo sapiens_hsa051340.51004329
117Insulin secretion_Homo sapiens_hsa049110.49244701
118Basal cell carcinoma_Homo sapiens_hsa052170.47946482
119Wnt signaling pathway_Homo sapiens_hsa043100.45702390
120Antigen processing and presentation_Homo sapiens_hsa046120.44655644
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44395188
122Starch and sucrose metabolism_Homo sapiens_hsa005000.43757144
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40276626
124Collecting duct acid secretion_Homo sapiens_hsa049660.39604302
125Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38822871
126Retinol metabolism_Homo sapiens_hsa008300.38445530
127Metabolic pathways_Homo sapiens_hsa011000.37975489
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37799599
129Cardiac muscle contraction_Homo sapiens_hsa042600.36926119
130TGF-beta signaling pathway_Homo sapiens_hsa043500.36848292
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36776113
132Fatty acid metabolism_Homo sapiens_hsa012120.35425538
133Hippo signaling pathway_Homo sapiens_hsa043900.34141502
134Rheumatoid arthritis_Homo sapiens_hsa053230.33278707
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.31833968
136African trypanosomiasis_Homo sapiens_hsa051430.30989374
137Glycerolipid metabolism_Homo sapiens_hsa005610.30625553
138Jak-STAT signaling pathway_Homo sapiens_hsa046300.27967380
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27863744
140Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27422325
141Adherens junction_Homo sapiens_hsa045200.25639541
142Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24035723
143Epstein-Barr virus infection_Homo sapiens_hsa051690.23710954
144Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23281947

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