SLC13A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an apical membrane Na(+)-sulfate cotransporter involved in sulfate homeostasis in the kidney. Defects in this gene lead to many pathophysiologic problems. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transmembrane transport (GO:0006855)9.43868556
2urate metabolic process (GO:0046415)9.14381828
3aminoglycoside antibiotic metabolic process (GO:0030647)9.05473188
4lipoprotein transport (GO:0042953)8.32887859
5drug transport (GO:0015893)8.02593828
6vitamin D metabolic process (GO:0042359)7.50081755
7organic cation transport (GO:0015695)7.41784819
8epoxygenase P450 pathway (GO:0019373)7.32243311
9regulation of guanylate cyclase activity (GO:0031282)7.30258962
10drug catabolic process (GO:0042737)6.88972103
11phosphate ion transport (GO:0006817)6.68297451
12fat-soluble vitamin biosynthetic process (GO:0042362)6.67506007
13positive regulation of guanylate cyclase activity (GO:0031284)6.17846190
14exogenous drug catabolic process (GO:0042738)6.09291961
15regulation of triglyceride catabolic process (GO:0010896)6.03119788
16excretion (GO:0007588)6.02915087
17fat-soluble vitamin catabolic process (GO:0042363)5.96715153
18vitamin catabolic process (GO:0009111)5.96715153
19cellular glucuronidation (GO:0052695)5.66934431
20phosphate ion homeostasis (GO:0055062)5.59839768
21trivalent inorganic anion homeostasis (GO:0072506)5.59839768
22quaternary ammonium group transport (GO:0015697)5.58185833
23cellular response to vitamin D (GO:0071305)5.55715478
24phosphate ion transmembrane transport (GO:0035435)5.45455710
25regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.35371149
26endocrine process (GO:0050886)5.35371149
27regulation of systemic arterial blood pressure by hormone (GO:0001990)5.35371149
28toxin transport (GO:1901998)5.34748565
29hormone catabolic process (GO:0042447)5.24938038
30adhesion of symbiont to host cell (GO:0044650)5.24721163
31virion attachment to host cell (GO:0019062)5.24721163
32modified amino acid transport (GO:0072337)5.22655702
33renal absorption (GO:0070293)5.22012886
34nonribosomal peptide biosynthetic process (GO:0019184)5.10924919
35lysine metabolic process (GO:0006553)5.07274183
36lysine catabolic process (GO:0006554)5.07274183
37oligosaccharide catabolic process (GO:0009313)5.06978774
38bile acid and bile salt transport (GO:0015721)4.98840595
39polyol transport (GO:0015791)4.95373735
40regulation of systemic arterial blood pressure (GO:0003073)4.82052531
41digestion (GO:0007586)4.81188767
42homocysteine metabolic process (GO:0050667)4.78830197
43vitamin A metabolic process (GO:0006776)4.69579938
44metanephric tubule development (GO:0072170)4.63052018
45metanephric nephron tubule development (GO:0072234)4.63052018
46peptide hormone processing (GO:0016486)4.60928938
47glutathione biosynthetic process (GO:0006750)4.51102637
48regulation of cGMP biosynthetic process (GO:0030826)4.44868299
49alkaloid metabolic process (GO:0009820)4.32322670
50peptide catabolic process (GO:0043171)4.29562232
51adhesion of symbiont to host (GO:0044406)4.29395110
52metanephric nephron epithelium development (GO:0072243)4.27703268
53glycoside metabolic process (GO:0016137)4.26413082
54cysteine metabolic process (GO:0006534)4.25356708
55intestinal absorption (GO:0050892)4.22134072
56vitamin biosynthetic process (GO:0009110)4.22118642
57cellular response to vitamin (GO:0071295)4.18448454
58receptor guanylyl cyclase signaling pathway (GO:0007168)4.18331463
59bicarbonate transport (GO:0015701)4.14399663
60glyoxylate metabolic process (GO:0046487)4.08064968
61drinking behavior (GO:0042756)4.07872572
62peptide biosynthetic process (GO:0043043)4.07717081
63heme transport (GO:0015886)4.05109958
64nephron tubule development (GO:0072080)4.04456780
65very-low-density lipoprotein particle assembly (GO:0034379)4.04237893
66carnitine transport (GO:0015879)4.03984265
67amino-acid betaine transport (GO:0015838)4.03984265
68transepithelial transport (GO:0070633)4.03810247
69metanephric epithelium development (GO:0072207)4.01265350
70* sulfur compound transport (GO:0072348)3.96647241
71angiotensin maturation (GO:0002003)3.94140012
72pyrimidine ribonucleoside catabolic process (GO:0046133)3.93163400
73cellular anion homeostasis (GO:0030002)3.90997896
74regulation of bile acid biosynthetic process (GO:0070857)3.90279378
75renal system process involved in regulation of blood volume (GO:0001977)3.86763368
76cGMP biosynthetic process (GO:0006182)3.84633097
77diacylglycerol metabolic process (GO:0046339)3.83306911
78sulfation (GO:0051923)3.80803815
79response to mercury ion (GO:0046689)3.79802127
80regulation of cGMP metabolic process (GO:0030823)3.76780723
81lipoprotein metabolic process (GO:0042157)3.76588590
82fructose metabolic process (GO:0006000)3.71509328
83renal tubule development (GO:0061326)3.71278428
84omega-hydroxylase P450 pathway (GO:0097267)3.66896534
85tricarboxylic acid metabolic process (GO:0072350)3.64199000
86glomerulus development (GO:0032835)3.63126648
87positive regulation of cGMP biosynthetic process (GO:0030828)3.60316568
88purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.59459976
893-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.59459976
90positive regulation of icosanoid secretion (GO:0032305)3.56648612
91bile acid metabolic process (GO:0008206)3.53007416
92regulation of cellular extravasation (GO:0002691)3.52632165
93positive regulation of fatty acid transport (GO:2000193)3.51026223
94quinone biosynthetic process (GO:1901663)3.50799100
95flavonoid metabolic process (GO:0009812)3.49140448
96histamine transport (GO:0051608)3.47792452
97glycine transport (GO:0015816)3.47269693
98plasma lipoprotein particle assembly (GO:0034377)3.46706827
99phospholipid scrambling (GO:0017121)3.46141311
100* sodium ion transport (GO:0006814)3.46107258
101nephron epithelium morphogenesis (GO:0072088)3.46087360
102nephron tubule morphogenesis (GO:0072078)3.46087360
103vitamin transmembrane transport (GO:0035461)3.44946679
104vitamin transport (GO:0051180)3.44925058
105arginine metabolic process (GO:0006525)3.44845359
106cobalamin metabolic process (GO:0009235)3.44681780
107cellular response to nitric oxide (GO:0071732)3.42320838
108short-chain fatty acid metabolic process (GO:0046459)3.40278835
109proline metabolic process (GO:0006560)3.40249433
110proline transport (GO:0015824)3.37047892
111cytidine metabolic process (GO:0046087)3.33525327
112cytidine catabolic process (GO:0006216)3.33525327
113cytidine deamination (GO:0009972)3.33525327
114sodium-independent organic anion transport (GO:0043252)3.32253895
115glycolipid catabolic process (GO:0019377)3.31745848
116* sulfate transmembrane transport (GO:1902358)3.30376667
117positive regulation of lipid catabolic process (GO:0050996)3.30176714
118regulation of apoptotic process involved in morphogenesis (GO:1902337)3.29520663
119glutathione derivative metabolic process (GO:1901685)3.28330655
120glutathione derivative biosynthetic process (GO:1901687)3.28330655
121mRNA modification (GO:0016556)3.26964976
122urea cycle (GO:0000050)3.26380857
123nephron epithelium development (GO:0072009)3.25995240
124L-ascorbic acid metabolic process (GO:0019852)3.25645030
125phenol-containing compound catabolic process (GO:0019336)3.25247477
126negative regulation of gene silencing (GO:0060969)3.22897445
127response to vitamin D (GO:0033280)3.21450842
128sphingomyelin metabolic process (GO:0006684)3.20820803
129negative regulation of keratinocyte proliferation (GO:0010839)3.19866425
130alditol metabolic process (GO:0019400)3.19770428
131urea metabolic process (GO:0019627)3.19144366
132glycosphingolipid catabolic process (GO:0046479)3.18230720
133glutathione metabolic process (GO:0006749)3.16692978
134cholesterol homeostasis (GO:0042632)3.14718493
135high-density lipoprotein particle remodeling (GO:0034375)3.14689749
136fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.14688995
137fat-soluble vitamin metabolic process (GO:0006775)3.14307064
138branched-chain amino acid metabolic process (GO:0009081)3.13469554
139sterol homeostasis (GO:0055092)3.12039063
140positive regulation of cGMP metabolic process (GO:0030825)3.11462375
141auditory receptor cell differentiation (GO:0042491)3.11358111
142glycosylceramide metabolic process (GO:0006677)3.10980897
143regulation of protein glycosylation (GO:0060049)3.10255983
144sodium ion homeostasis (GO:0055078)3.07346997
145digestive system process (GO:0022600)3.06849506
146positive regulation of triglyceride metabolic process (GO:0090208)3.06538763
147regulation of vitamin metabolic process (GO:0030656)3.03232499
148bone remodeling (GO:0046849)3.00520708
149aspartate family amino acid catabolic process (GO:0009068)2.96791745
150neurotransmitter biosynthetic process (GO:0042136)2.94374774
151NADH metabolic process (GO:0006734)2.92233561
152glycerol metabolic process (GO:0006071)2.91423651
153response to magnesium ion (GO:0032026)2.91261882
154regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.89714461
155uronic acid metabolic process (GO:0006063)2.89673159
156glucuronate metabolic process (GO:0019585)2.89673159
157response to phenylpropanoid (GO:0080184)2.89414997
158positive regulation of digestive system process (GO:0060456)2.89179749
159calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.88179125
160drug metabolic process (GO:0017144)2.87760593
161cellular carbohydrate catabolic process (GO:0044275)2.85916020
162glucocorticoid biosynthetic process (GO:0006704)2.85663921
163membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.85280308
164* sulfate transport (GO:0008272)2.85114135
165tryptophan metabolic process (GO:0006568)2.84916047
166amino-acid betaine metabolic process (GO:0006577)2.84290179
167superoxide anion generation (GO:0042554)2.83230638
168renal tubule morphogenesis (GO:0061333)2.83175896

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.87694428
2GBX2_23144817_ChIP-Seq_PC3_Human2.70222302
3CDX2_20551321_ChIP-Seq_CACO-2_Human2.65168908
4CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.54512129
5CDX2_19796622_ChIP-Seq_MESCs_Mouse2.34221272
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.33372769
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.18781248
8VDR_22108803_ChIP-Seq_LS180_Human2.10555945
9PCGF2_27294783_Chip-Seq_NPCs_Mouse2.07166800
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06089847
11* IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.05244722
12FLI1_27457419_Chip-Seq_LIVER_Mouse1.97244823
13CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.96880321
14SUZ12_27294783_Chip-Seq_NPCs_Mouse1.96826582
15PIAS1_25552417_ChIP-Seq_VCAP_Human1.94439938
16PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88254248
17EZH2_22144423_ChIP-Seq_EOC_Human1.86400214
18FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.82643295
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.77844219
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73514267
21NFE2_27457419_Chip-Seq_LIVER_Mouse1.72145726
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.70936284
23GATA1_22025678_ChIP-Seq_K562_Human1.65187577
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63430213
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.60001706
26IGF1R_20145208_ChIP-Seq_DFB_Human1.59947875
27EZH2_27294783_Chip-Seq_NPCs_Mouse1.58676326
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54580201
29* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.53634807
30STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.53452668
31BCAT_22108803_ChIP-Seq_LS180_Human1.53398796
32* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.51006002
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50400559
34SMAD3_21741376_ChIP-Seq_HESCs_Human1.49242703
35TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48443950
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.48439481
37SUZ12_18555785_Chip-Seq_ESCs_Mouse1.47610561
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47300395
39P53_22387025_ChIP-Seq_ESCs_Mouse1.45532755
40E2F1_18555785_Chip-Seq_ESCs_Mouse1.44432106
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44182121
42NANOG_18555785_Chip-Seq_ESCs_Mouse1.42704903
43* GATA4_25053715_ChIP-Seq_YYC3_Human1.42156051
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41927518
45EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.40220856
46HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.37426990
47RXR_22158963_ChIP-Seq_LIVER_Mouse1.37262304
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.37120190
49RXR_22108803_ChIP-Seq_LS180_Human1.34565929
50STAT3_18555785_Chip-Seq_ESCs_Mouse1.33683731
51OCT4_18555785_Chip-Seq_ESCs_Mouse1.33151446
52ESRRB_18555785_Chip-Seq_ESCs_Mouse1.33008318
53TCF4_22108803_ChIP-Seq_LS180_Human1.32810401
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32454562
55EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30739114
56* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29896321
57ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29790730
58LXR_22158963_ChIP-Seq_LIVER_Mouse1.29255114
59SMAD4_21799915_ChIP-Seq_A2780_Human1.29214090
60EGR1_23403033_ChIP-Seq_LIVER_Mouse1.28130629
61PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.28047360
62CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27768784
63SOX2_18555785_Chip-Seq_ESCs_Mouse1.27722774
64P300_18555785_Chip-Seq_ESCs_Mouse1.25907995
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25017533
66TRIM28_21343339_ChIP-Seq_HEK293_Human1.23972051
67ZFX_18555785_Chip-Seq_ESCs_Mouse1.23704879
68CMYC_18555785_Chip-Seq_ESCs_Mouse1.23392023
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21716960
70PRDM14_20953172_ChIP-Seq_ESCs_Human1.21625063
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.19614094
72SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.19498249
73SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.19252203
74RUNX1_27457419_Chip-Seq_LIVER_Mouse1.18695172
75* P300_19829295_ChIP-Seq_ESCs_Human1.18206149
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17463219
77TCF4_18268006_ChIP-ChIP_LS174T_Human1.16371336
78CDX2_22108803_ChIP-Seq_LS180_Human1.15869512
79NMYC_18555785_Chip-Seq_ESCs_Mouse1.15795501
80FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14904634
81KLF4_18555785_Chip-Seq_ESCs_Mouse1.14461659
82SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14091168
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13999695
84FOXA1_25552417_ChIP-Seq_VCAP_Human1.13887293
85AHR_22903824_ChIP-Seq_MCF-7_Human1.13813680
86IRF8_22096565_ChIP-ChIP_GC-B_Human1.12941664
87OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12693475
88EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.12555665
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12539313
90SOX2_20726797_ChIP-Seq_SW620_Human1.12140433
91* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11662921
92AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11622027
93CJUN_26792858_Chip-Seq_BT549_Human1.11539160
94NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.11217149
95CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10530141
96FOXA1_25329375_ChIP-Seq_VCAP_Human1.10360402
97FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10360402
98HNF4A_19822575_ChIP-Seq_HepG2_Human1.09460828
99CRX_20693478_ChIP-Seq_RETINA_Mouse1.09381913
100CTCF_18555785_Chip-Seq_ESCs_Mouse1.09219170
101EED_16625203_ChIP-ChIP_MESCs_Mouse1.09077247
102PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08956580
103NCOR_22424771_ChIP-Seq_293T_Human1.08558020
104SMAD4_21741376_ChIP-Seq_HESCs_Human1.08254622
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07894859
106ER_23166858_ChIP-Seq_MCF-7_Human1.07872293
107TAL1_26923725_Chip-Seq_HPCs_Mouse1.07234312
108FUS_26573619_Chip-Seq_HEK293_Human1.05447971
109CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04780081
110SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04631101
111STAT1_17558387_ChIP-Seq_HELA_Human1.04150851
112CBX2_27304074_Chip-Seq_ESCs_Mouse1.03792917
113KDM2B_26808549_Chip-Seq_REH_Human1.03737996
114DROSHA_22980978_ChIP-Seq_HELA_Human1.03724413
115SMAD1_18555785_Chip-Seq_ESCs_Mouse1.03665291
116ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02870272
117TAF15_26573619_Chip-Seq_HEK293_Human1.02669933
118* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02655908
119IRF8_21731497_ChIP-ChIP_J774_Mouse1.02413072
120SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02285349
121TCF4_23295773_ChIP-Seq_U87_Human1.02024023
122ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01377170
123* STAT3_23295773_ChIP-Seq_U87_Human1.01339741
124SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.01201407
125FOXO3_23340844_ChIP-Seq_DLD1_Human1.00947707
126ZNF274_21170338_ChIP-Seq_K562_Hela1.00945210
127ESR2_21235772_ChIP-Seq_MCF-7_Human1.00870494
128PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00299180
129NANOG_20526341_ChIP-Seq_ESCs_Human1.00148435
130TAF2_19829295_ChIP-Seq_ESCs_Human1.00120718
131* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00063156
132GATA6_25053715_ChIP-Seq_YYC3_Human0.99794141
133P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99635027
134PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99501174
135AR_25329375_ChIP-Seq_VCAP_Human0.99445980
136PU1_27457419_Chip-Seq_LIVER_Mouse0.98634763
137RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98633224
138SMAD3_21741376_ChIP-Seq_EPCs_Human0.98075548
139TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97664845
140EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96693412
141RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96128309
142TP63_23658742_ChIP-Seq_EP156T_Human0.95500733
143ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95424791
144AR_20517297_ChIP-Seq_VCAP_Human0.95062090
145NANOG_19829295_ChIP-Seq_ESCs_Human0.93080097
146SOX2_19829295_ChIP-Seq_ESCs_Human0.93080097
147MYC_19829295_ChIP-Seq_ESCs_Human0.92342521
148ETV1_20927104_ChIP-Seq_GIST48_Human0.91391058

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.49157607
2MP0004043_abnormal_pH_regulation5.83048182
3MP0004019_abnormal_vitamin_homeostasis5.41886347
4MP0002138_abnormal_hepatobiliary_system4.59104729
5MP0001765_abnormal_ion_homeostasis3.77092908
6MP0003195_calcinosis3.75971303
7MP0005332_abnormal_amino_acid3.67512503
8MP0009379_abnormal_foot_pigmentation3.51662421
9MP0003878_abnormal_ear_physiology3.45241427
10MP0005377_hearing/vestibular/ear_phenot3.45241427
11MP0002139_abnormal_hepatobiliary_system3.44178086
12MP0003252_abnormal_bile_duct3.32932451
13* MP0009643_abnormal_urine_homeostasis3.32770049
14MP0009840_abnormal_foam_cell3.01403685
15* MP0002136_abnormal_kidney_physiology2.67903568
16* MP0005636_abnormal_mineral_homeostasis2.67675190
17MP0001756_abnormal_urination2.55103371
18MP0000538_abnormal_urinary_bladder2.30417218
19MP0008875_abnormal_xenobiotic_pharmacok2.23495439
20MP0004264_abnormal_extraembryonic_tissu2.14330838
21MP0001666_abnormal_nutrient_absorption2.14018216
22MP0005085_abnormal_gallbladder_physiolo2.08858082
23MP0002876_abnormal_thyroid_physiology2.03040925
24MP0003300_gastrointestinal_ulcer1.96897864
25MP0005451_abnormal_body_composition1.93119534
26MP0001958_emphysema1.91499893
27MP0004147_increased_porphyrin_level1.90083318
28MP0005084_abnormal_gallbladder_morpholo1.89510202
29MP0003868_abnormal_feces_composition1.68977953
30MP0002928_abnormal_bile_duct1.60944687
31MP0000566_synostosis1.55421092
32MP0003718_maternal_effect1.55131646
33MP0001501_abnormal_sleep_pattern1.51700700
34MP0003183_abnormal_peptide_metabolism1.37816742
35MP0008961_abnormal_basal_metabolism1.29825327
36MP0008872_abnormal_physiological_respon1.27759958
37MP0005448_abnormal_energy_balance1.27306233
38MP0010386_abnormal_urinary_bladder1.21427443
39MP0004270_analgesia1.20729007
40MP0002168_other_aberrant_phenotype1.18556267
41MP0000678_abnormal_parathyroid_gland1.13749539
42MP0003806_abnormal_nucleotide_metabolis1.13106963
43MP0004885_abnormal_endolymph1.09438681
44MP0005058_abnormal_lysosome_morphology1.08350064
45MP0000230_abnormal_systemic_arterial1.07173273
46MP0000462_abnormal_digestive_system1.02371964
47MP0009764_decreased_sensitivity_to1.01077724
48MP0005174_abnormal_tail_pigmentation0.98206706
49MP0001663_abnormal_digestive_system0.96392406
50MP0003186_abnormal_redox_activity0.94843727
51MP0002135_abnormal_kidney_morphology0.92471777
52MP0005409_darkened_coat_color0.91812825
53MP0002896_abnormal_bone_mineralization0.91801870
54* MP0005365_abnormal_bile_salt0.91515497
55MP0002822_catalepsy0.89544898
56MP0002089_abnormal_postnatal_growth/wei0.89121927
57MP0005381_digestive/alimentary_phenotyp0.88493428
58MP0001664_abnormal_digestion0.84697264
59MP0002098_abnormal_vibrissa_morphology0.84497137
60MP0002277_abnormal_respiratory_mucosa0.84029080
61MP0001764_abnormal_homeostasis0.81620988
62MP0003045_fibrosis0.81201808
63MP0000609_abnormal_liver_physiology0.79425984
64MP0005310_abnormal_salivary_gland0.78717099
65MP0000569_abnormal_digit_pigmentation0.77643366
66MP0003866_abnormal_defecation0.76684611
67MP0004742_abnormal_vestibular_system0.76415617
68MP0002971_abnormal_brown_adipose0.75972312
69MP0005220_abnormal_exocrine_pancreas0.75358937
70MP0003941_abnormal_skin_development0.72841044
71MP0005670_abnormal_white_adipose0.71508014
72MP0001188_hyperpigmentation0.70029230
73MP0002998_abnormal_bone_remodeling0.69139140
74MP0005319_abnormal_enzyme/_coenzyme0.68738690
75* MP0005584_abnormal_enzyme/coenzyme_acti0.66755230
76MP0003191_abnormal_cellular_cholesterol0.64728876
77MP0005395_other_phenotype0.62882285
78MP0005166_decreased_susceptibility_to0.62606943
79MP0001963_abnormal_hearing_physiology0.60983885
80MP0005408_hypopigmentation0.60853446
81MP0009115_abnormal_fat_cell0.60522438
82* MP0009642_abnormal_blood_homeostasis0.60320973
83MP0005535_abnormal_body_temperature0.60307881
84MP0010155_abnormal_intestine_physiology0.59338365
85MP0000015_abnormal_ear_pigmentation0.59298993
86MP0003283_abnormal_digestive_organ0.59024347
87MP0001485_abnormal_pinna_reflex0.58129650
88MP0003879_abnormal_hair_cell0.58093588
89MP0005551_abnormal_eye_electrophysiolog0.57115620
90MP0000427_abnormal_hair_cycle0.57065229
91MP0000490_abnormal_crypts_of0.55500647
92MP0002078_abnormal_glucose_homeostasis0.55499029
93MP0000026_abnormal_inner_ear0.55106401
94MP0002069_abnormal_eating/drinking_beha0.54789180
95MP0001440_abnormal_grooming_behavior0.53684382
96MP0000371_diluted_coat_color0.52780796
97MP0003795_abnormal_bone_structure0.51769973
98MP0002118_abnormal_lipid_homeostasis0.51519551
99MP0001177_atelectasis0.50269524
100MP0005257_abnormal_intraocular_pressure0.49666917
101MP0003315_abnormal_perineum_morphology0.49433630
102MP0002272_abnormal_nervous_system0.49380776
103MP0005334_abnormal_fat_pad0.49357806
104MP0001845_abnormal_inflammatory_respons0.47624207
105MP0003638_abnormal_response/metabolism_0.47608074
106MP0001986_abnormal_taste_sensitivity0.47237029
107MP0002102_abnormal_ear_morphology0.46911229
108MP0000477_abnormal_intestine_morphology0.45752640
109MP0003646_muscle_fatigue0.45503513
110MP0005666_abnormal_adipose_tissue0.44219436
111MP0002733_abnormal_thermal_nociception0.44157939
112MP0000534_abnormal_ureter_morphology0.43883620
113MP0010234_abnormal_vibrissa_follicle0.43841946
114MP0005646_abnormal_pituitary_gland0.43422318
115MP0005501_abnormal_skin_physiology0.43208555
116MP0002734_abnormal_mechanical_nocicepti0.42398544
117MP0001191_abnormal_skin_condition0.42338470
118MP0010329_abnormal_lipoprotein_level0.42111070
119MP0002396_abnormal_hematopoietic_system0.41900695
120MP0004215_abnormal_myocardial_fiber0.41793382
121MP0009697_abnormal_copulation0.41172347
122MP0009780_abnormal_chondrocyte_physiolo0.41000372
123MP0010678_abnormal_skin_adnexa0.40786518
124MP0002638_abnormal_pupillary_reflex0.40752312
125MP0003938_abnormal_ear_development0.40393484
126MP0004924_abnormal_behavior0.39824772
127MP0005386_behavior/neurological_phenoty0.39824772
128* MP0003953_abnormal_hormone_level0.39702133
129MP0001873_stomach_inflammation0.39198098
130MP0008469_abnormal_protein_level0.38878471
131MP0004484_altered_response_of0.38793483
132MP0005165_increased_susceptibility_to0.37756103
133MP0003172_abnormal_lysosome_physiology0.36917957
134MP0005376_homeostasis/metabolism_phenot0.36596773
135MP0001186_pigmentation_phenotype0.36186696
136* MP0002115_abnormal_skeleton_extremities0.35665670
137MP0000163_abnormal_cartilage_morphology0.34813005
138MP0004145_abnormal_muscle_electrophysio0.33920480
139MP0000383_abnormal_hair_follicle0.32913749

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)7.64868278
2Metabolic alkalosis (HP:0200114)7.30000236
3Hyperactive renin-angiotensin system (HP:0000841)7.21003850
4Polyuria (HP:0000103)6.79267014
5Hypokalemic alkalosis (HP:0001949)6.72781111
6Abnormal urine output (HP:0012590)6.41488378
7Hypomagnesemia (HP:0002917)6.40582669
8Abnormality of chloride homeostasis (HP:0011422)6.39192123
9Abnormality of renal excretion (HP:0011036)6.17518777
10Hypobetalipoproteinemia (HP:0003563)5.79834438
11Abnormality of magnesium homeostasis (HP:0004921)5.49584739
12Gout (HP:0001997)5.47642845
13Proximal tubulopathy (HP:0000114)5.24793038
14Abnormality of renin-angiotensin system (HP:0000847)5.21164920
15Abnormal drinking behavior (HP:0030082)5.11826615
16Polydipsia (HP:0001959)5.11826615
17Abnormality of glutamine family amino acid metabolism (HP:0010902)5.09599810
18Tetany (HP:0001281)5.07547298
19Hyperaldosteronism (HP:0000859)4.77586537
20Pigmentary retinal degeneration (HP:0001146)4.65561823
21Acanthocytosis (HP:0001927)4.58023770
22Alkalosis (HP:0001948)4.54486616
23Hypercalciuria (HP:0002150)4.32298763
24Hyperuricemia (HP:0002149)4.28445818
25Increased purine levels (HP:0004368)4.28445818
26Fat malabsorption (HP:0002630)4.26457729
27Abnormality of vitamin metabolism (HP:0100508)4.11956298
28Renal salt wasting (HP:0000127)4.05111037
29Abnormality of purine metabolism (HP:0004352)4.03933724
30Abnormality of urine glucose concentration (HP:0011016)3.80953420
31Glycosuria (HP:0003076)3.80953420
32Hypokalemia (HP:0002900)3.80034972
33Renal tubular acidosis (HP:0001947)3.71531949
34Hydroxyprolinuria (HP:0003080)3.71134026
35Abnormality of proline metabolism (HP:0010907)3.71134026
36Hyperglycinuria (HP:0003108)3.60233518
37Megaloblastic anemia (HP:0001889)3.45097681
38Generalized aminoaciduria (HP:0002909)3.41801078
39Dehydration (HP:0001944)3.25996146
40Abnormality of potassium homeostasis (HP:0011042)3.25600033
41Nephrocalcinosis (HP:0000121)3.23560991
42Widely patent fontanelles and sutures (HP:0004492)3.11209985
43Delayed epiphyseal ossification (HP:0002663)3.03185879
44Abnormal urine phosphate concentration (HP:0012599)2.97817603
45Abnormality of nucleobase metabolism (HP:0010932)2.97303386
46Hyperphosphaturia (HP:0003109)2.92118159
47Nausea (HP:0002018)2.87192939
48Nephrolithiasis (HP:0000787)2.81773100
49Hypophosphatemia (HP:0002148)2.80142384
50Hypolipoproteinemia (HP:0010981)2.74324834
51Vascular calcification (HP:0004934)2.72327081
52Potter facies (HP:0002009)2.69364307
53Facial shape deformation (HP:0011334)2.69364307
54Confusion (HP:0001289)2.66922433
55Xanthomatosis (HP:0000991)2.63593226
56Steatorrhea (HP:0002570)2.62804994
57Abnormality of serine family amino acid metabolism (HP:0010894)2.62205471
58Abnormality of glycine metabolism (HP:0010895)2.62205471
59Enlarged kidneys (HP:0000105)2.57676725
60Decreased circulating renin level (HP:0003351)2.51194390
61Abnormality of aspartate family amino acid metabolism (HP:0010899)2.48481546
62Chronic diarrhea (HP:0002028)2.43783580
63Chorioretinal atrophy (HP:0000533)2.39607778
64Rickets (HP:0002748)2.38770682
65Renal tubular dysfunction (HP:0000124)2.36709447
66Cardiovascular calcification (HP:0011915)2.36601308
67Hyponatremia (HP:0002902)2.36448214
68Malnutrition (HP:0004395)2.36079173
69Abnormality of renal resorption (HP:0011038)2.32601144
70Focal segmental glomerulosclerosis (HP:0000097)2.32144324
71Posterior subcapsular cataract (HP:0007787)2.31293024
72Abnormality of sodium homeostasis (HP:0010931)2.29380808
73Abdominal distention (HP:0003270)2.27372668
74Conjugated hyperbilirubinemia (HP:0002908)2.26349513
75Ketoacidosis (HP:0001993)2.22761176
76Hypotension (HP:0002615)2.19959187
77Vacuolated lymphocytes (HP:0001922)2.19347545
78Abnormality of the renal cortex (HP:0011035)2.18013439
79Poikilocytosis (HP:0004447)2.15680538
80Abnormality of the vitamin B12 metabolism (HP:0004341)2.15119650
81Osteomalacia (HP:0002749)2.15024573
82Tubulointerstitial fibrosis (HP:0005576)2.14915824
83Metaphyseal irregularity (HP:0003025)2.14628032
84Congenital sensorineural hearing impairment (HP:0008527)2.13876413
85Epidermoid cyst (HP:0200040)2.12595471
86Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.12395643
87Hyperammonemia (HP:0001987)2.08583181
88Tubular atrophy (HP:0000092)2.06225928
89Alveolar cell carcinoma (HP:0006519)2.05128775
90Thin bony cortex (HP:0002753)2.03491703
91Ileus (HP:0002595)1.99702984
92Abnormality of vitamin B metabolism (HP:0004340)1.97158680
93Abnormal enzyme/coenzyme activity (HP:0012379)1.96123341
94Abnormality of alkaline phosphatase activity (HP:0004379)1.94494933
95Hyperventilation (HP:0002883)1.93547200
96Bilateral sensorineural hearing impairment (HP:0008619)1.93293610
97Abnormal albumin level (HP:0012116)1.92321969
98Hypoalbuminemia (HP:0003073)1.92321969
99Hypothermia (HP:0002045)1.91448128
100Irritability (HP:0000737)1.89315178
101Enlarged epiphyses (HP:0010580)1.87853570
102Metabolic acidosis (HP:0001942)1.84908875
103Metaphyseal cupping (HP:0003021)1.84055411
104Adrenal overactivity (HP:0002717)1.83922553
105Lethargy (HP:0001254)1.83465746
106Methylmalonic aciduria (HP:0012120)1.82356901
107Neoplasm of the tracheobronchial system (HP:0100552)1.81865274
108Elfin facies (HP:0004428)1.81093069
109Autoimmune thrombocytopenia (HP:0001973)1.80074038
110Abnormality of the renal medulla (HP:0100957)1.77655064
111Abnormality of calcium-phosphate metabolism (HP:0100530)1.75759433
112Abnormality of sulfur amino acid metabolism (HP:0004339)1.74784578
113Abnormality of monocarboxylic acid metabolism (HP:0010996)1.74483581
114Abnormality of carpal bone ossification (HP:0006257)1.73823230
115Hyperphosphatemia (HP:0002905)1.73555487
116Hyperkalemia (HP:0002153)1.73084513
117Abnormal tarsal ossification (HP:0008369)1.72124232
118Abnormality of the fingertips (HP:0001211)1.71589470
119Abnormality of fatty-acid metabolism (HP:0004359)1.70155806
120Abnormality of the costochondral junction (HP:0000919)1.69812402
121Bicornuate uterus (HP:0000813)1.67153655
122Macrocytic anemia (HP:0001972)1.66547119
123Vomiting (HP:0002013)1.66489289
124Tubulointerstitial abnormality (HP:0001969)1.65800072
125Abnormality of Sharpey fibers (HP:0100685)1.65278214
126Hypophosphatemic rickets (HP:0004912)1.63821938
127Glomerulosclerosis (HP:0000096)1.62566492
128Ketosis (HP:0001946)1.60678484
129Wide cranial sutures (HP:0010537)1.59179058
130Protuberant abdomen (HP:0001538)1.58232044
131Hyperparathyroidism (HP:0000843)1.57314301
132Cerebral palsy (HP:0100021)1.54521188

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B8.69873756
2WNK47.42210448
3OXSR16.46405900
4WNK36.28197247
5STK393.81718748
6FRK3.43438083
7STK38L2.76346270
8ZAK2.25016944
9MST1R2.20873188
10MST42.04879019
11INSRR1.99198743
12SGK2231.96456246
13SGK4941.96456246
14MAP3K141.67406812
15SGK21.65474419
16MAP3K101.64645774
17LMTK21.64240027
18MAP3K91.60845388
19AKT31.55322021
20PIK3CG1.53972487
21SGK31.53517067
22IRAK31.50885116
23WNK11.34323037
24NUAK11.28795362
25SIK31.28770571
26STK381.21661095
27EPHA41.17120022
28LATS11.14034018
29DAPK21.06489767
30NLK1.02013151
31EPHB20.96012655
32TNIK0.92210406
33TTK0.90234553
34ERN10.89666395
35CASK0.85180450
36STK160.79874868
37DDR20.77035438
38MAP3K70.76925305
39PRKAA20.76390370
40PRKACG0.75617588
41NME10.75442230
42ERBB40.74975301
43SGK10.72959110
44MAP3K120.71829877
45TXK0.71692393
46PINK10.70995107
47MET0.69348043
48GRK10.68952557
49TEC0.68640847
50YES10.68531300
51MATK0.68163561
52CAMKK20.67552504
53TAF10.63477229
54GSK3A0.63439649
55PDK20.62434894
56MAP2K20.61601831
57PRKAA10.59122165
58PRKG20.59083916
59IRAK40.55926723
60EIF2AK20.55529806
61GRK60.53094406
62MAPK110.52789603
63MAP2K60.52311248
64PAK30.52182704
65PNCK0.51953686
66TYK20.51938090
67NEK60.51470668
68FGFR30.50723059
69STK30.50671142
70EPHB10.50356944
71PDK40.50244602
72PDK30.50244602
73CDK80.48053720
74ADRBK10.48050359
75CAMK2A0.47514407
76NTRK30.46366056
77MAP3K130.45806072
78CDK120.45210394
79BRD40.44496257
80MAP2K70.42680662
81MAP3K30.42284486
82CHUK0.41820760
83PRKCI0.41569669
84TGFBR20.41380691
85IRAK10.41163190
86ITK0.40766158
87PTK60.40674783
88STK240.40189640
89MAP4K20.40051492
90CSNK1A10.39989786
91BMPR20.38943120
92NTRK20.38111124
93TLK10.36359150
94EPHA20.35077805
95BCKDK0.34838610
96TESK20.34287236
97PRKG10.34203248
98MYLK0.31540013
99ERBB20.31243723
100CDK30.30819848
101TAOK10.30679440
102BMPR1B0.30565807
103PTK20.30345267
104PDK10.30241496
105MARK10.30154290
106PRKCA0.29967502
107MAPK70.29931360
108PRKCQ0.28703044
109MAPK150.28687302
110ADRBK20.28622699
111PRKCD0.28201043
112MAPK130.28113336
113FGFR40.27796976
114AKT20.27463022
115PRKCE0.27311604
116TYRO30.27013688
117PRPF4B0.25800894
118PRKD20.25329084
119STK110.24961688
120SRC0.24331067
121IKBKE0.23660817
122CAMK1G0.23531515
123ABL20.23487732
124FER0.23364282
125PIK3CA0.23209531
126IGF1R0.22417218
127CHEK20.21961640
128RIPK40.21912692
129SRPK10.21892662
130PDPK10.21707489
131PRKCZ0.21100207
132PRKACA0.20462474
133PRKCG0.19839091
134PBK0.19570089
135EPHA30.19228825
136STK100.19128898
137DYRK20.19070818
138MAP3K60.18906710
139FYN0.18890989
140MAP4K10.18735777
141TAOK30.18513521
142ROCK10.18227027
143PIM10.18036999
144ERBB30.18031697
145CAMK1D0.17761737
146MAP3K20.17259993
147DMPK0.16930494
148RIPK10.16928481
149IRAK20.16823015
150JAK10.16547991
151MAP3K40.16325962

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin digestion and absorption_Homo sapiens_hsa049774.13517119
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.69478847
3Mineral absorption_Homo sapiens_hsa049783.40395448
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.88265983
5Cyanoamino acid metabolism_Homo sapiens_hsa004602.83766344
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.81127750
7Butanoate metabolism_Homo sapiens_hsa006502.68763878
8Collecting duct acid secretion_Homo sapiens_hsa049662.58516588
9Renin-angiotensin system_Homo sapiens_hsa046142.51354119
10Linoleic acid metabolism_Homo sapiens_hsa005912.48202410
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.47062602
12Protein digestion and absorption_Homo sapiens_hsa049742.25806895
13Sulfur metabolism_Homo sapiens_hsa009202.19361832
14Propanoate metabolism_Homo sapiens_hsa006402.07677716
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.06869752
16Bile secretion_Homo sapiens_hsa049762.05947237
17Peroxisome_Homo sapiens_hsa041462.00728450
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.00430399
19Starch and sucrose metabolism_Homo sapiens_hsa005001.92137916
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.82959791
21Carbohydrate digestion and absorption_Homo sapiens_hsa049731.82735119
22Tryptophan metabolism_Homo sapiens_hsa003801.77705237
23beta-Alanine metabolism_Homo sapiens_hsa004101.76942213
24Glutathione metabolism_Homo sapiens_hsa004801.75948609
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.74323734
26Other glycan degradation_Homo sapiens_hsa005111.69622731
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.63705630
28Fatty acid degradation_Homo sapiens_hsa000711.63070012
29Pyruvate metabolism_Homo sapiens_hsa006201.56791801
30Arginine and proline metabolism_Homo sapiens_hsa003301.45374138
31Lysine degradation_Homo sapiens_hsa003101.44155882
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40562230
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.40470387
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.38123079
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.36801592
36Histidine metabolism_Homo sapiens_hsa003401.34562464
37Sphingolipid metabolism_Homo sapiens_hsa006001.23278153
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20527183
39Steroid biosynthesis_Homo sapiens_hsa001001.17623840
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17173184
41Fat digestion and absorption_Homo sapiens_hsa049751.16839752
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.13389940
43Folate biosynthesis_Homo sapiens_hsa007901.11255715
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10176570
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.07271130
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06132971
47Fructose and mannose metabolism_Homo sapiens_hsa000511.05605797
48PPAR signaling pathway_Homo sapiens_hsa033201.05083777
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98713213
50ABC transporters_Homo sapiens_hsa020100.95630027
51Fatty acid metabolism_Homo sapiens_hsa012120.91885100
52Glycerolipid metabolism_Homo sapiens_hsa005610.89603746
53Arachidonic acid metabolism_Homo sapiens_hsa005900.87322525
54Thyroid hormone synthesis_Homo sapiens_hsa049180.83877391
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80337909
56Carbon metabolism_Homo sapiens_hsa012000.75863659
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.75281267
58Galactose metabolism_Homo sapiens_hsa000520.73340498
59Phenylalanine metabolism_Homo sapiens_hsa003600.73178702
60Fatty acid biosynthesis_Homo sapiens_hsa000610.64687833
61Gastric acid secretion_Homo sapiens_hsa049710.63026131
62Retinol metabolism_Homo sapiens_hsa008300.57786754
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56213444
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55114091
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52364769
66Glycerophospholipid metabolism_Homo sapiens_hsa005640.51628971
67Serotonergic synapse_Homo sapiens_hsa047260.50926184
68Arginine biosynthesis_Homo sapiens_hsa002200.47976841
69Chemical carcinogenesis_Homo sapiens_hsa052040.47910943
70Metabolic pathways_Homo sapiens_hsa011000.47569486
71Vibrio cholerae infection_Homo sapiens_hsa051100.46666038
72Lysosome_Homo sapiens_hsa041420.46293854
73Rheumatoid arthritis_Homo sapiens_hsa053230.44393801
74Cocaine addiction_Homo sapiens_hsa050300.44097095
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41665454
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.41468915
77Selenocompound metabolism_Homo sapiens_hsa004500.40946078
78Asthma_Homo sapiens_hsa053100.40786358
79Renin secretion_Homo sapiens_hsa049240.40352759
80Choline metabolism in cancer_Homo sapiens_hsa052310.40139000
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.39160514
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35348432
83Inositol phosphate metabolism_Homo sapiens_hsa005620.35115252
84Caffeine metabolism_Homo sapiens_hsa002320.34767031
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33866988
86Tyrosine metabolism_Homo sapiens_hsa003500.32699134
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.31729509
88Nitrogen metabolism_Homo sapiens_hsa009100.31335862
89Hepatitis C_Homo sapiens_hsa051600.30160135
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28452190
91Pentose phosphate pathway_Homo sapiens_hsa000300.27869131
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.22694976
93Sulfur relay system_Homo sapiens_hsa041220.22462445
94Insulin resistance_Homo sapiens_hsa049310.21860752
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.19191559
96Amphetamine addiction_Homo sapiens_hsa050310.17875330
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.13759746
98Glucagon signaling pathway_Homo sapiens_hsa049220.13097234
99Allograft rejection_Homo sapiens_hsa053300.11848208
100Nicotine addiction_Homo sapiens_hsa050330.11195491
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.11042202
102Autoimmune thyroid disease_Homo sapiens_hsa053200.10946046
103Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.10916194
104Pancreatic secretion_Homo sapiens_hsa049720.10566594
105Graft-versus-host disease_Homo sapiens_hsa053320.10151930
106Fatty acid elongation_Homo sapiens_hsa000620.09885716
107Type I diabetes mellitus_Homo sapiens_hsa049400.08570509
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.08317584
109Synaptic vesicle cycle_Homo sapiens_hsa047210.08235444
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.07597919
111Circadian rhythm_Homo sapiens_hsa047100.06730416
112Insulin secretion_Homo sapiens_hsa049110.06339594
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.04528824
114Long-term depression_Homo sapiens_hsa047300.04414914
115Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.04402922
116Taste transduction_Homo sapiens_hsa047420.04244170
117Oxidative phosphorylation_Homo sapiens_hsa001900.03871112
118ECM-receptor interaction_Homo sapiens_hsa045120.02914939
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.02393012
120Type II diabetes mellitus_Homo sapiens_hsa049300.02182940
121Dopaminergic synapse_Homo sapiens_hsa047280.02070794
122Phagosome_Homo sapiens_hsa041450.00585762
123Hematopoietic cell lineage_Homo sapiens_hsa046400.00528799
124Salivary secretion_Homo sapiens_hsa049700.00397151
125Ether lipid metabolism_Homo sapiens_hsa005650.00192519
126Retrograde endocannabinoid signaling_Homo sapiens_hsa04723-0.0432305
127Glutamatergic synapse_Homo sapiens_hsa04724-0.0309642
128Cholinergic synapse_Homo sapiens_hsa04725-0.0093102
129Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0003879

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