SLC13A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1urate metabolic process (GO:0046415)8.26986397
2drug transmembrane transport (GO:0006855)8.08886427
3aminoglycoside antibiotic metabolic process (GO:0030647)7.75165984
4glyoxylate metabolic process (GO:0046487)6.99191062
5lysine catabolic process (GO:0006554)6.92850819
6lysine metabolic process (GO:0006553)6.92850819
7drug transport (GO:0015893)6.91345245
8organic cation transport (GO:0015695)6.24468496
9phosphate ion transport (GO:0006817)6.22892940
10cysteine metabolic process (GO:0006534)6.16707226
11drug catabolic process (GO:0042737)6.05135949
12exogenous drug catabolic process (GO:0042738)5.93159442
13L-phenylalanine catabolic process (GO:0006559)5.93143821
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.93143821
15L-phenylalanine metabolic process (GO:0006558)5.85087646
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.85087646
17axonemal dynein complex assembly (GO:0070286)5.80299260
18response to mercury ion (GO:0046689)5.47519188
19aromatic amino acid family catabolic process (GO:0009074)5.38851039
20quaternary ammonium group transport (GO:0015697)5.34774654
21phosphate ion transmembrane transport (GO:0035435)5.23398106
22cellular modified amino acid catabolic process (GO:0042219)5.07204063
23aspartate family amino acid catabolic process (GO:0009068)5.06249442
24short-chain fatty acid metabolic process (GO:0046459)5.05760069
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.01963537
26homocysteine metabolic process (GO:0050667)4.99874244
27serine family amino acid catabolic process (GO:0009071)4.99845409
28indole-containing compound catabolic process (GO:0042436)4.92170674
29indolalkylamine catabolic process (GO:0046218)4.92170674
30tryptophan catabolic process (GO:0006569)4.92170674
31tricarboxylic acid metabolic process (GO:0072350)4.89968591
32tryptophan metabolic process (GO:0006568)4.70100346
33amino-acid betaine metabolic process (GO:0006577)4.58642054
34vitamin D metabolic process (GO:0042359)4.58290057
35serine family amino acid metabolic process (GO:0009069)4.51715276
36cilium or flagellum-dependent cell motility (GO:0001539)4.48521432
37branched-chain amino acid metabolic process (GO:0009081)4.47557518
38cilium movement (GO:0003341)4.43797482
39nonribosomal peptide biosynthetic process (GO:0019184)4.42986407
40epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.42920604
41cellular ketone body metabolic process (GO:0046950)4.41159403
42sulfur amino acid catabolic process (GO:0000098)4.40550555
43excretion (GO:0007588)4.36949795
44negative regulation of sterol transport (GO:0032372)4.30779990
45negative regulation of cholesterol transport (GO:0032375)4.30779990
46glutamate metabolic process (GO:0006536)4.20830438
47renal absorption (GO:0070293)4.17215882
48epithelial cilium movement (GO:0003351)4.15508138
49valine metabolic process (GO:0006573)4.13150982
50serine family amino acid biosynthetic process (GO:0009070)4.11586745
51fructose metabolic process (GO:0006000)4.11219670
52cellular amino acid catabolic process (GO:0009063)4.10670816
53alpha-amino acid catabolic process (GO:1901606)4.09918523
54fatty acid beta-oxidation (GO:0006635)4.08406194
55kynurenine metabolic process (GO:0070189)4.05719772
56phosphate ion homeostasis (GO:0055062)4.04971437
57trivalent inorganic anion homeostasis (GO:0072506)4.04971437
58proline metabolic process (GO:0006560)4.04570658
59glutathione biosynthetic process (GO:0006750)4.02324089
60axon ensheathment in central nervous system (GO:0032291)4.00810529
61central nervous system myelination (GO:0022010)4.00810529
62modified amino acid transport (GO:0072337)3.98243703
632-oxoglutarate metabolic process (GO:0006103)3.95809956
64aromatic amino acid family metabolic process (GO:0009072)3.95397451
65negative regulation of fibrinolysis (GO:0051918)3.94639665
66branched-chain amino acid catabolic process (GO:0009083)3.93434744
67amino-acid betaine transport (GO:0015838)3.91191872
68carnitine transport (GO:0015879)3.91191872
69fatty acid oxidation (GO:0019395)3.90887082
70lipid oxidation (GO:0034440)3.90613472
71carnitine metabolic process (GO:0009437)3.90582555
72vitamin transmembrane transport (GO:0035461)3.90037675
73intestinal cholesterol absorption (GO:0030299)3.84988239
74acetyl-CoA metabolic process (GO:0006084)3.82809161
75ketone body metabolic process (GO:1902224)3.79465647
76regulation of fibrinolysis (GO:0051917)3.77989779
77metanephric tubule development (GO:0072170)3.71852893
78metanephric nephron tubule development (GO:0072234)3.71852893
79toxin transport (GO:1901998)3.71013643
80embryonic retina morphogenesis in camera-type eye (GO:0060059)3.69109866
81organic acid catabolic process (GO:0016054)3.66792451
82carboxylic acid catabolic process (GO:0046395)3.66792451
83bile acid biosynthetic process (GO:0006699)3.65676206
84dicarboxylic acid biosynthetic process (GO:0043650)3.65045811
85peptidyl-glutamic acid carboxylation (GO:0017187)3.63511064
86protein carboxylation (GO:0018214)3.63511064
87fatty acid catabolic process (GO:0009062)3.58898883
88regulation of protein activation cascade (GO:2000257)3.56020611
89monocarboxylic acid catabolic process (GO:0072329)3.54167033
90alpha-linolenic acid metabolic process (GO:0036109)3.53482176
91regulation of bile acid biosynthetic process (GO:0070857)3.50047929
92indolalkylamine metabolic process (GO:0006586)3.47195734
93flavonoid metabolic process (GO:0009812)3.45232754
94aldehyde catabolic process (GO:0046185)3.44485501
95very-low-density lipoprotein particle assembly (GO:0034379)3.42646669
96metanephric nephron epithelium development (GO:0072243)3.39797807
97benzene-containing compound metabolic process (GO:0042537)3.39725519
98regulation of complement activation (GO:0030449)3.39082034
99polyol transport (GO:0015791)3.38651742
100drug metabolic process (GO:0017144)3.38194224
101indole-containing compound metabolic process (GO:0042430)3.37499319
102glutamine family amino acid catabolic process (GO:0009065)3.37473990
103ethanol metabolic process (GO:0006067)3.31131389
104regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.30851257
105sodium-independent organic anion transport (GO:0043252)3.30591237
106glycoside metabolic process (GO:0016137)3.29849745
107glutathione metabolic process (GO:0006749)3.29035209
108amine catabolic process (GO:0009310)3.28750039
109cellular biogenic amine catabolic process (GO:0042402)3.28750039
110primary alcohol catabolic process (GO:0034310)3.27827718
111peptide biosynthetic process (GO:0043043)3.26975581
112response to phenylpropanoid (GO:0080184)3.25659356
113regulation of cholesterol homeostasis (GO:2000188)3.25172983
114uronic acid metabolic process (GO:0006063)3.24032719
115glucuronate metabolic process (GO:0019585)3.24032719
116regulation of non-canonical Wnt signaling pathway (GO:2000050)3.21129447
117tyrosine metabolic process (GO:0006570)3.20462686
118response to growth hormone (GO:0060416)3.20336490
119small molecule catabolic process (GO:0044282)3.19607381
120dicarboxylic acid metabolic process (GO:0043648)3.18964606
121negative regulation of astrocyte differentiation (GO:0048712)3.17672403
122motile cilium assembly (GO:0044458)3.16343637
123glutathione derivative biosynthetic process (GO:1901687)3.16258785
124glutathione derivative metabolic process (GO:1901685)3.16258785
125regulation of gene silencing by RNA (GO:0060966)3.15978035
126regulation of posttranscriptional gene silencing (GO:0060147)3.15978035
127regulation of gene silencing by miRNA (GO:0060964)3.15978035
128cellular glucuronidation (GO:0052695)3.13023623
129peptide catabolic process (GO:0043171)3.12148233
130biotin metabolic process (GO:0006768)3.11693256
131blood coagulation, intrinsic pathway (GO:0007597)3.07924499
132plasma lipoprotein particle assembly (GO:0034377)3.06741878
133plasma lipoprotein particle remodeling (GO:0034369)3.05917681
134protein-lipid complex remodeling (GO:0034368)3.05917681
135macromolecular complex remodeling (GO:0034367)3.05917681
136regulation of apoptotic cell clearance (GO:2000425)3.05665728
137nephron epithelium morphogenesis (GO:0072088)3.05102881
138nephron tubule morphogenesis (GO:0072078)3.05102881
139low-density lipoprotein particle remodeling (GO:0034374)3.02182047
140cholesterol efflux (GO:0033344)3.00556924
141positive regulation of dendritic spine morphogenesis (GO:0061003)2.94439166
142ethanol oxidation (GO:0006069)2.91794087
143glycine metabolic process (GO:0006544)2.90355556
144axoneme assembly (GO:0035082)2.88161788
145C4-dicarboxylate transport (GO:0015740)2.85738523
146lung epithelium development (GO:0060428)2.85295555
147neurotransmitter-gated ion channel clustering (GO:0072578)2.84296824
148cellular sodium ion homeostasis (GO:0006883)2.83425501
149regulation of cilium movement (GO:0003352)2.83085756
150otic vesicle formation (GO:0030916)2.78134312
151sodium ion homeostasis (GO:0055078)2.74333943
152high-density lipoprotein particle remodeling (GO:0034375)2.72099881
153gamma-aminobutyric acid transport (GO:0015812)2.69716568
154collecting duct development (GO:0072044)2.63610644
155peptidyl-glutamic acid modification (GO:0018200)2.62991323
156reverse cholesterol transport (GO:0043691)2.62539180
157metanephric epithelium development (GO:0072207)2.60563979
158plasma lipoprotein particle organization (GO:0071827)2.59521239
159triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.59173492
160regulation of cholesterol esterification (GO:0010872)2.58672978
161mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.57996891
162protein-lipid complex assembly (GO:0065005)2.57316497
163neuronal action potential propagation (GO:0019227)2.57029062
164L-serine metabolic process (GO:0006563)2.55756989
165negative regulation of protein localization to cell surface (GO:2000009)2.55639736
166negative regulation of sodium ion transport (GO:0010766)2.54227508
167regulation of plasminogen activation (GO:0010755)2.47265028
168peristalsis (GO:0030432)2.46360010
169postsynaptic membrane organization (GO:0001941)2.46019523
170renal tubule morphogenesis (GO:0061333)2.43254910
171complement activation, alternative pathway (GO:0006957)2.42319403
172G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.40281697
173protein-lipid complex subunit organization (GO:0071825)2.35423797
174behavioral response to nicotine (GO:0035095)2.34326385
175cochlea development (GO:0090102)2.33843650
176L-ascorbic acid metabolic process (GO:0019852)2.32115598

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.38434011
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.18040303
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.15858275
4* LXR_22158963_ChIP-Seq_LIVER_Mouse4.65778964
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.25323469
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.36002874
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.27457798
8EZH2_22144423_ChIP-Seq_EOC_Human3.12486665
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.68640310
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.64169463
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.55252298
12AR_21572438_ChIP-Seq_LNCaP_Human2.27833243
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.18746234
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14822151
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13563176
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09129672
17ZNF274_21170338_ChIP-Seq_K562_Hela2.06711899
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.05421438
19GBX2_23144817_ChIP-Seq_PC3_Human2.04895777
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.04313690
21CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.02913798
22TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.92045166
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.91804847
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.87232134
25ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.79163263
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.73323445
27CLOCK_20551151_ChIP-Seq_293T_Human1.72573115
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.72343934
29REST_21632747_ChIP-Seq_MESCs_Mouse1.69394258
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.57065156
31* FOXA2_19822575_ChIP-Seq_HepG2_Human1.54471021
32CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.52320762
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.51981547
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.45418857
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44305457
36IGF1R_20145208_ChIP-Seq_DFB_Human1.43462323
37* HNF4A_19822575_ChIP-Seq_HepG2_Human1.42610209
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41499143
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.40969017
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.40062628
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.38429671
42LXR_22292898_ChIP-Seq_THP-1_Human1.37635209
43CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.34998736
44CDX2_20551321_ChIP-Seq_CACO-2_Human1.32688951
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27895343
46TAF15_26573619_Chip-Seq_HEK293_Human1.27376527
47RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27284274
48EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27284274
49RNF2_27304074_Chip-Seq_NSC_Mouse1.23795525
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22235643
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22235643
52JARID2_20064375_ChIP-Seq_MESCs_Mouse1.22043022
53STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.21742584
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21485647
55ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20884413
56NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.20077523
57SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.18223818
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15865451
59P300_19829295_ChIP-Seq_ESCs_Human1.14583095
60FUS_26573619_Chip-Seq_HEK293_Human1.13451568
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13232511
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13111591
63BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12800188
64* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12578182
65JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12562315
66SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12505312
67SOX2_27498859_Chip-Seq_STOMACH_Mouse1.12470157
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.12005002
69* REST_18959480_ChIP-ChIP_MESCs_Mouse1.11760030
70SMAD4_21799915_ChIP-Seq_A2780_Human1.10215113
71ERG_21242973_ChIP-ChIP_JURKAT_Human1.09316822
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09273259
73* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08916268
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08771458
75TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08733419
76GATA1_26923725_Chip-Seq_HPCs_Mouse1.08579176
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07390684
78RXR_22108803_ChIP-Seq_LS180_Human1.07212066
79EZH2_27304074_Chip-Seq_ESCs_Mouse1.06350213
80EGR1_19032775_ChIP-ChIP_M12_Human1.05160026
81KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.04052930
82KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.04052930
83KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.04052930
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.03940985
85P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03772145
86GATA4_25053715_ChIP-Seq_YYC3_Human1.02808276
87SOX2_16153702_ChIP-ChIP_HESCs_Human1.02393382
88ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01735343
89IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01717653
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00762603
91RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00266936
92* ER_23166858_ChIP-Seq_MCF-7_Human1.00181579
93FOXO3_23340844_ChIP-Seq_DLD1_Human0.99567756
94RUNX2_22187159_ChIP-Seq_PCA_Human0.99312156
95AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99278522
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98727361
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98486467
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98118193
99SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97488677
100* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.96970048
101POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96736747
102RACK7_27058665_Chip-Seq_MCF-7_Human0.95623274
103* STAT3_23295773_ChIP-Seq_U87_Human0.95393648
104ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95323831
105RING1B_27294783_Chip-Seq_ESCs_Mouse0.95107954
106RNF2_27304074_Chip-Seq_ESCs_Mouse0.94564340
107PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93950038
108ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93263926
109ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93203528
110GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.92906198
111SALL1_21062744_ChIP-ChIP_HESCs_Human0.92862169
112PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92370454
113Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.92043897
114FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91692525
115AR_21909140_ChIP-Seq_LNCAP_Human0.91264116
116* AR_19668381_ChIP-Seq_PC3_Human0.91113106
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90315601
118NANOG_16153702_ChIP-ChIP_HESCs_Human0.89936939
119SMAD3_21741376_ChIP-Seq_ESCs_Human0.89900640
120ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88982580
121ESR1_20079471_ChIP-ChIP_T-47D_Human0.88937057
122NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88425267
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88425267
124TCF4_22108803_ChIP-Seq_LS180_Human0.88104060
125KAP1_22055183_ChIP-Seq_ESCs_Mouse0.87974507
126TCF4_23295773_ChIP-Seq_U87_Human0.87938958
127RAD21_21589869_ChIP-Seq_MESCs_Mouse0.87616758
128* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87430856
129RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87154847
130PIAS1_25552417_ChIP-Seq_VCAP_Human0.86386636
131TBX20_22080862_ChIP-Seq_HEART_Mouse0.83957539
132TBX20_22328084_ChIP-Seq_HEART_Mouse0.83957539
133SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.82059603
134GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81668198
135EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.79668126
136TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.76785399
137PPAR_26484153_Chip-Seq_NCI-H1993_Human0.75552834
138* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.75136005
139MYC_19915707_ChIP-ChIP_AK7_Human0.74626345
140GATA1_19941826_ChIP-Seq_K562_Human0.74458602
141VDR_22108803_ChIP-Seq_LS180_Human0.74316869
142SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.74235762
143SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.72825648
144BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.72688832
145SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.72219376
146TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.71777503
147TAF2_19829295_ChIP-Seq_ESCs_Human0.71774003
148CTCF_27219007_Chip-Seq_Bcells_Human0.69340324
149* SMAD4_21741376_ChIP-Seq_HESCs_Human0.68951791
150SOX2_20726797_ChIP-Seq_SW620_Human0.68642265
151SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.67995443
152* SMAD3_21741376_ChIP-Seq_HESCs_Human0.67989543
153TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.67985536
154P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.67137366
155SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67114632
156DROSHA_22980978_ChIP-Seq_HELA_Human0.66870626
157MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.66350375
158GATA1_19941827_ChIP-Seq_MEL_Mouse0.65154313
159TP63_23658742_ChIP-Seq_EP156T_Human0.64820807
160STAT3_1855785_ChIP-Seq_MESCs_Mouse0.64582058
161DNAJC2_21179169_ChIP-ChIP_NT2_Human0.64173856
162* GATA2_19941826_ChIP-Seq_K562_Human0.64111681
163GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.63978275
164WT1_25993318_ChIP-Seq_PODOCYTE_Human0.63881492
165SUZ12_27294783_Chip-Seq_ESCs_Mouse0.63785449
166SMC4_20622854_ChIP-Seq_HELA_Human0.62641784
167EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.62516208
168CBP_21632823_ChIP-Seq_H3396_Human0.60902175
169GATA6_25053715_ChIP-Seq_YYC3_Human0.60774381
170CDX2_22108803_ChIP-Seq_LS180_Human0.59683366
171TP63_22573176_ChIP-Seq_HFKS_Human0.59554389
172GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.59469508
173SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.58799517
174RXRA_24833708_ChIP-Seq_LIVER_Mouse0.58259107
175AUTS2_25519132_ChIP-Seq_293T-REX_Human0.58042497

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.81727364
2MP0002139_abnormal_hepatobiliary_system6.09221904
3MP0004043_abnormal_pH_regulation4.82690334
4MP0005332_abnormal_amino_acid4.65980013
5MP0004019_abnormal_vitamin_homeostasis4.48272711
6MP0003195_calcinosis3.71491390
7MP0008875_abnormal_xenobiotic_pharmacok3.58919851
8MP0005365_abnormal_bile_salt3.51633036
9MP0000566_synostosis3.35631461
10MP0002138_abnormal_hepatobiliary_system3.34795490
11MP0009643_abnormal_urine_homeostasis3.31556461
12MP0005085_abnormal_gallbladder_physiolo3.29015134
13MP0006292_abnormal_olfactory_placode3.11909870
14MP0003122_maternal_imprinting2.94009746
15MP0001765_abnormal_ion_homeostasis2.93559177
16MP0003252_abnormal_bile_duct2.79830015
17MP0005636_abnormal_mineral_homeostasis2.67643182
18MP0001756_abnormal_urination2.49711138
19MP0005058_abnormal_lysosome_morphology2.38274654
20MP0002136_abnormal_kidney_physiology2.33699651
21MP0003136_yellow_coat_color2.29544123
22MP0003806_abnormal_nucleotide_metabolis2.08986161
23MP0001958_emphysema1.99819563
24MP0003191_abnormal_cellular_cholesterol1.97544431
25MP0003878_abnormal_ear_physiology1.94099470
26MP0005377_hearing/vestibular/ear_phenot1.94099470
27MP0005584_abnormal_enzyme/coenzyme_acti1.91700020
28MP0010329_abnormal_lipoprotein_level1.88032552
29MP0003186_abnormal_redox_activity1.80924881
30MP0004270_analgesia1.79029007
31MP0009840_abnormal_foam_cell1.72159146
32MP0003880_abnormal_central_pattern1.66681296
33MP0008789_abnormal_olfactory_epithelium1.64317327
34MP0001293_anophthalmia1.64177288
35MP0004885_abnormal_endolymph1.63613065
36MP0002653_abnormal_ependyma_morphology1.61728157
37MP0001529_abnormal_vocalization1.58819236
38MP0002938_white_spotting1.57870210
39MP0010030_abnormal_orbit_morphology1.57036241
40MP0005319_abnormal_enzyme/_coenzyme1.56033914
41MP0005423_abnormal_somatic_nervous1.53796360
42MP0003941_abnormal_skin_development1.53709120
43MP0002118_abnormal_lipid_homeostasis1.46410567
44MP0005499_abnormal_olfactory_system1.45540637
45MP0005394_taste/olfaction_phenotype1.45540637
46MP0003123_paternal_imprinting1.45413066
47MP0004133_heterotaxia1.44501631
48MP0005083_abnormal_biliary_tract1.39265831
49MP0001984_abnormal_olfaction1.39261583
50MP0005451_abnormal_body_composition1.39178249
51MP0001486_abnormal_startle_reflex1.32549021
52MP0001666_abnormal_nutrient_absorption1.32358760
53MP0005551_abnormal_eye_electrophysiolog1.32153082
54MP0009780_abnormal_chondrocyte_physiolo1.31722232
55MP0003690_abnormal_glial_cell1.31485849
56MP0009046_muscle_twitch1.29639785
57MP0003300_gastrointestinal_ulcer1.26041536
58MP0003890_abnormal_embryonic-extraembry1.25916452
59MP0003121_genomic_imprinting1.25173038
60MP0002249_abnormal_larynx_morphology1.25071003
61MP0003329_amyloid_beta_deposits1.24707978
62MP0002160_abnormal_reproductive_system1.23809124
63MP0001270_distended_abdomen1.21697201
64MP0003938_abnormal_ear_development1.19173667
65MP0000609_abnormal_liver_physiology1.18752363
66MP0000678_abnormal_parathyroid_gland1.18250049
67MP0003942_abnormal_urinary_system1.16694427
68MP0002822_catalepsy1.14883573
69MP0000538_abnormal_urinary_bladder1.14865788
70MP0000604_amyloidosis1.14060773
71MP0000049_abnormal_middle_ear1.13228373
72MP0005670_abnormal_white_adipose1.12247612
73MP0001764_abnormal_homeostasis1.11658112
74MP0002734_abnormal_mechanical_nocicepti1.11516054
75MP0001968_abnormal_touch/_nociception1.10511233
76MP0002064_seizures1.09589445
77MP0004858_abnormal_nervous_system1.08908520
78MP0009745_abnormal_behavioral_response1.08079159
79MP0005084_abnormal_gallbladder_morpholo1.08050008
80MP0003172_abnormal_lysosome_physiology1.06838509
81MP0002272_abnormal_nervous_system1.06593806
82MP0005535_abnormal_body_temperature1.05686230
83MP0000230_abnormal_systemic_arterial1.05618769
84MP0008961_abnormal_basal_metabolism1.04866398
85MP0002233_abnormal_nose_morphology1.02709349
86MP0010368_abnormal_lymphatic_system1.02639221
87MP0003635_abnormal_synaptic_transmissio1.02573967
88MP0000631_abnormal_neuroendocrine_gland1.02531594
89MP0002168_other_aberrant_phenotype1.00434967
90MP0006036_abnormal_mitochondrial_physio0.99424324
91MP0003718_maternal_effect0.96010391
92MP0009764_decreased_sensitivity_to0.95869757
93MP0002282_abnormal_trachea_morphology0.95169687
94MP0003937_abnormal_limbs/digits/tail_de0.93063384
95MP0000778_abnormal_nervous_system0.91214640
96MP0005646_abnormal_pituitary_gland0.90172669
97MP0002876_abnormal_thyroid_physiology0.90135131
98MP0000026_abnormal_inner_ear0.90062204
99MP0000955_abnormal_spinal_cord0.89361766
100MP0002234_abnormal_pharynx_morphology0.89183414
101MP0002135_abnormal_kidney_morphology0.88099448
102MP0003868_abnormal_feces_composition0.87910383
103MP0002928_abnormal_bile_duct0.87693874
104MP0003075_altered_response_to0.87591776
105MP0004859_abnormal_synaptic_plasticity0.87397255
106MP0009642_abnormal_blood_homeostasis0.87032058
107MP0002557_abnormal_social/conspecific_i0.86849647
108MP0002638_abnormal_pupillary_reflex0.86696634
109MP0001963_abnormal_hearing_physiology0.85991425
110MP0001299_abnormal_eye_distance/0.85225072
111MP0002063_abnormal_learning/memory/cond0.84645292
112MP0000534_abnormal_ureter_morphology0.84524174
113MP0002735_abnormal_chemical_nociception0.84485558
114MP0002572_abnormal_emotion/affect_behav0.84292974
115MP0005666_abnormal_adipose_tissue0.84187386
116MP0003638_abnormal_response/metabolism_0.80842835
117MP0002736_abnormal_nociception_after0.80812341
118MP0002089_abnormal_postnatal_growth/wei0.79506459
119MP0003567_abnormal_fetal_cardiomyocyte0.79250221
120MP0003950_abnormal_plasma_membrane0.78518877
121MP0002184_abnormal_innervation0.76941406
122MP0004147_increased_porphyrin_level0.76794955
123MP0002752_abnormal_somatic_nervous0.74557127
124MP0002067_abnormal_sensory_capabilities0.73977266
125MP0001286_abnormal_eye_development0.73946544
126MP0008469_abnormal_protein_level0.73880655
127MP0006276_abnormal_autonomic_nervous0.72145785
128MP0000920_abnormal_myelination0.72055979
129MP0003315_abnormal_perineum_morphology0.71745872
130MP0005187_abnormal_penis_morphology0.71343605
131MP0000598_abnormal_liver_morphology0.69906954
132MP0003011_delayed_dark_adaptation0.68491127
133MP0005167_abnormal_blood-brain_barrier0.68098125
134MP0001661_extended_life_span0.66693926
135MP0002896_abnormal_bone_mineralization0.66037864
136MP0005165_increased_susceptibility_to0.65578337
137MP0003705_abnormal_hypodermis_morpholog0.64495486
138MP0002254_reproductive_system_inflammat0.63357794
139MP0005395_other_phenotype0.58578651
140MP0003633_abnormal_nervous_system0.58414863
141MP0005166_decreased_susceptibility_to0.56900663
142MP0002078_abnormal_glucose_homeostasis0.56730445
143MP0000747_muscle_weakness0.54212265
144MP0003646_muscle_fatigue0.51646884
145MP0002796_impaired_skin_barrier0.50436286
146MP0002971_abnormal_brown_adipose0.48867759
147MP0003656_abnormal_erythrocyte_physiolo0.47306426
148MP0004264_abnormal_extraembryonic_tissu0.44997922
149MP0005220_abnormal_exocrine_pancreas0.44857506
150MP0003953_abnormal_hormone_level0.44646620
151MP0001485_abnormal_pinna_reflex0.43703735
152MP0002069_abnormal_eating/drinking_beha0.43524317
153MP0003631_nervous_system_phenotype0.43330235
154MP0005595_abnormal_vascular_smooth0.42897706
155MP0004742_abnormal_vestibular_system0.42143944
156MP0005376_homeostasis/metabolism_phenot0.40701716
157MP0002998_abnormal_bone_remodeling0.39139186
158MP0005408_hypopigmentation0.38844241
159MP0009763_increased_sensitivity_to0.37891637
160MP0005647_abnormal_sex_gland0.36739657
161MP0003879_abnormal_hair_cell0.36737876
162MP0006035_abnormal_mitochondrial_morpho0.34020384
163MP0002115_abnormal_skeleton_extremities0.33945168
164MP0009765_abnormal_xenobiotic_induced0.33350280
165MP0000371_diluted_coat_color0.33012794
166MP0002295_abnormal_pulmonary_circulatio0.32891448
167MP0009384_cardiac_valve_regurgitation0.32571263
168MP0008874_decreased_physiological_sensi0.32522541
169MP0009672_abnormal_birth_weight0.30547926
170MP0003724_increased_susceptibility_to0.30516209

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)6.81051317
2Hypokalemic alkalosis (HP:0001949)6.40290747
3Gout (HP:0001997)6.39152169
4Metabolic alkalosis (HP:0200114)6.32634603
5Polyuria (HP:0000103)5.67717266
6Hypomagnesemia (HP:0002917)5.61692262
7Hyperactive renin-angiotensin system (HP:0000841)5.58747399
8Abnormal urine output (HP:0012590)5.45236049
9Abnormality of renal excretion (HP:0011036)5.16651368
10Abnormality of chloride homeostasis (HP:0011422)5.12363200
11Proximal tubulopathy (HP:0000114)5.00247654
12Hyperglycinuria (HP:0003108)4.98658119
13Abnormality of glutamine family amino acid metabolism (HP:0010902)4.90598960
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.84653609
15Abnormality of magnesium homeostasis (HP:0004921)4.72296914
16Abnormal respiratory motile cilium morphology (HP:0005938)4.66493475
17Abnormal respiratory epithelium morphology (HP:0012253)4.66493475
18Abnormal drinking behavior (HP:0030082)4.59224751
19Polydipsia (HP:0001959)4.59224751
20Alkalosis (HP:0001948)4.56931941
21Hyperuricemia (HP:0002149)4.44241902
22Increased purine levels (HP:0004368)4.44241902
23Abnormal respiratory motile cilium physiology (HP:0012261)4.37571475
24Abnormal ciliary motility (HP:0012262)4.34821383
25Absent/shortened dynein arms (HP:0200106)4.33216213
26Dynein arm defect of respiratory motile cilia (HP:0012255)4.33216213
27Abnormality of glycine metabolism (HP:0010895)4.31356734
28Abnormality of serine family amino acid metabolism (HP:0010894)4.31356734
29Abnormality of purine metabolism (HP:0004352)4.30084694
30Abnormality of renin-angiotensin system (HP:0000847)4.10120096
31Generalized aminoaciduria (HP:0002909)4.06142825
32Renal salt wasting (HP:0000127)3.97171588
33Hyperaldosteronism (HP:0000859)3.94230146
34Ketosis (HP:0001946)3.82550245
35Rhinitis (HP:0012384)3.81880371
36Ketoacidosis (HP:0001993)3.79218084
37Tetany (HP:0001281)3.71298391
38Abnormality of aromatic amino acid family metabolism (HP:0004338)3.54808916
39Prolonged partial thromboplastin time (HP:0003645)3.50422963
40Abnormality of urine glucose concentration (HP:0011016)3.41548375
41Glycosuria (HP:0003076)3.41548375
42Abnormality of nucleobase metabolism (HP:0010932)3.39909769
43Renal tubular acidosis (HP:0001947)3.35254528
44Hypercalciuria (HP:0002150)3.34516696
45Hyperglycinemia (HP:0002154)3.29675503
46Abnormality of aspartate family amino acid metabolism (HP:0010899)3.24248591
47Chronic bronchitis (HP:0004469)3.23983338
48Hyperammonemia (HP:0001987)3.21680453
49Hydroxyprolinuria (HP:0003080)3.21628973
50Abnormality of proline metabolism (HP:0010907)3.21628973
51Xanthomatosis (HP:0000991)3.15289329
52Hypokalemia (HP:0002900)3.08249658
53Abnormality of fatty-acid metabolism (HP:0004359)3.06917922
54Delayed CNS myelination (HP:0002188)2.95523320
55Hyperphosphaturia (HP:0003109)2.92916327
56Vascular calcification (HP:0004934)2.92399224
57Abnormal urine phosphate concentration (HP:0012599)2.79731732
58Rickets (HP:0002748)2.77099781
59Abnormality of sulfur amino acid metabolism (HP:0004339)2.76962096
60Nephrolithiasis (HP:0000787)2.75260116
61Hypophosphatemia (HP:0002148)2.69935411
62Vacuolated lymphocytes (HP:0001922)2.69322506
63Nephrocalcinosis (HP:0000121)2.65216208
64Intrahepatic cholestasis (HP:0001406)2.61825445
65True hermaphroditism (HP:0010459)2.60964170
66Delayed epiphyseal ossification (HP:0002663)2.60336290
67Abnormality of potassium homeostasis (HP:0011042)2.60238972
68Cardiovascular calcification (HP:0011915)2.58985834
69Enlarged kidneys (HP:0000105)2.57743479
70Hypobetalipoproteinemia (HP:0003563)2.57271506
71Abnormality of dicarboxylic acid metabolism (HP:0010995)2.57020513
72Dicarboxylic aciduria (HP:0003215)2.57020513
73Widely patent fontanelles and sutures (HP:0004492)2.51473465
74Metabolic acidosis (HP:0001942)2.51021285
75Confusion (HP:0001289)2.50799653
76Vomiting (HP:0002013)2.42682347
77Abnormal enzyme/coenzyme activity (HP:0012379)2.40381538
78Abnormality of monocarboxylic acid metabolism (HP:0010996)2.34669937
79Hepatoblastoma (HP:0002884)2.29822349
80Pancreatic fibrosis (HP:0100732)2.28648820
81Abnormality of alkaline phosphatase activity (HP:0004379)2.28560107
82Bronchiectasis (HP:0002110)2.27093961
83Pancreatic cysts (HP:0001737)2.26797513
84Malnutrition (HP:0004395)2.26552375
85Complement deficiency (HP:0004431)2.26173986
86Sensorimotor neuropathy (HP:0007141)2.25830517
87Lethargy (HP:0001254)2.25732952
88Supernumerary spleens (HP:0009799)2.23213135
89Tubular atrophy (HP:0000092)2.16917700
90Metaphyseal cupping (HP:0003021)2.16743053
91Irritability (HP:0000737)2.15534282
92Dehydration (HP:0001944)2.12404284
93Hypoglycemic coma (HP:0001325)2.09086990
94Axonal loss (HP:0003447)2.08950922
95Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.07001834
96Abnormality of renal resorption (HP:0011038)2.06821543
97Methylmalonic aciduria (HP:0012120)2.05997938
98Deep venous thrombosis (HP:0002625)2.04758873
99Cystic liver disease (HP:0006706)2.03994755
100Renal tubular dysfunction (HP:0000124)2.03612859
101Abnormality of the renal medulla (HP:0100957)2.03335507
102Abnormality of sodium homeostasis (HP:0010931)2.02347658
103Abnormality of serum amino acid levels (HP:0003112)2.01357045
104Epidermoid cyst (HP:0200040)1.99130494
105Abnormal tarsal ossification (HP:0008369)1.96440972
106Elevated alkaline phosphatase (HP:0003155)1.93546235
107Hyponatremia (HP:0002902)1.93457756
108Hypophosphatemic rickets (HP:0004912)1.92152651
109Facial shape deformation (HP:0011334)1.91699773
110Potter facies (HP:0002009)1.91699773
111Neonatal onset (HP:0003623)1.89675242
112Osteomalacia (HP:0002749)1.87348004
113Late onset (HP:0003584)1.87165495
114Joint hemorrhage (HP:0005261)1.86073140
115Nausea (HP:0002018)1.84533618
116Hepatocellular carcinoma (HP:0001402)1.84362736
117Dysostosis multiplex (HP:0000943)1.83080320
118Adrenal overactivity (HP:0002717)1.82892836
119Lymphangioma (HP:0100764)1.82097886
120Nephronophthisis (HP:0000090)1.80400994
121Protuberant abdomen (HP:0001538)1.80369151
122Vaginal atresia (HP:0000148)1.80280575
123Chronic hepatic failure (HP:0100626)1.79386916
124Thin bony cortex (HP:0002753)1.79189944
125Epiphyseal dysplasia (HP:0002656)1.79169551
126Chondrocalcinosis (HP:0000934)1.78091191
127Occipital encephalocele (HP:0002085)1.76877355
128Bifid scrotum (HP:0000048)1.76776744
129Choanal stenosis (HP:0000452)1.76628875
130Genital tract atresia (HP:0001827)1.75812395
131Glomerulosclerosis (HP:0000096)1.75318003
132Nephrogenic diabetes insipidus (HP:0009806)1.75304187
133Cutaneous finger syndactyly (HP:0010554)1.74316011
134Tubulointerstitial fibrosis (HP:0005576)1.74151905
135Abnormality of the costochondral junction (HP:0000919)1.73849094
136Anophthalmia (HP:0000528)1.69607475
137Postaxial foot polydactyly (HP:0001830)1.68973246
138Myokymia (HP:0002411)1.67786752
139Aplasia/Hypoplasia of the tongue (HP:0010295)1.67135531
140Coronal craniosynostosis (HP:0004440)1.66408415
141Septo-optic dysplasia (HP:0100842)1.65148505
142Hypercholesterolemia (HP:0003124)1.64227183
143Hypotension (HP:0002615)1.62541760
144Bronchomalacia (HP:0002780)1.60915328
145Abnormality of carpal bone ossification (HP:0006257)1.56019222
146Infertility (HP:0000789)1.53042524
147Focal motor seizures (HP:0011153)1.49839666
148Abnormality of the labia minora (HP:0012880)1.49387878
149Anosmia (HP:0000458)1.46425068
150Cutaneous syndactyly (HP:0012725)1.46282330
151Decreased central vision (HP:0007663)1.46129534
152Abnormal biliary tract physiology (HP:0012439)1.44739659
153Bile duct proliferation (HP:0001408)1.44739659
154Arthropathy (HP:0003040)1.44663094
155Broad alveolar ridges (HP:0000187)1.44125462
156Abnormality of midbrain morphology (HP:0002418)1.43985616
157Molar tooth sign on MRI (HP:0002419)1.43985616

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK48.45771541
2OXSR16.71677671
3WNK36.32601560
4STK394.52455582
5BCKDK4.05521834
6SGK4942.21868050
7SGK2232.21868050
8NTRK31.95675745
9STK38L1.95083599
10MAP4K21.86123446
11WNK11.84725839
12PNCK1.81283830
13MAP3K91.76271743
14CASK1.67781588
15ERN11.65151516
16FGFR41.64680853
17EPHB11.60720978
18PDK31.56560174
19PDK41.56560174
20MARK11.52591562
21TYRO31.51983190
22TLK11.42585214
23ZAK1.38418312
24AKT31.38242951
25NEK11.31109294
26STK381.29471438
27MAP3K41.26274907
28SGK21.25040453
29FGFR11.23573012
30SGK31.23415048
31MAPKAPK51.19931479
32PRKD31.19444499
33MST1R1.17944347
34TRIB31.17917779
35PINK11.14114892
36DYRK21.14038719
37BMPR1B1.12180794
38GRK61.09247450
39PDK21.06720940
40GRK11.04555637
41LMTK21.04458681
42EPHA41.01838778
43SIK10.97820626
44TTK0.95946113
45TSSK60.89237044
46CDC70.87656433
47WEE10.87408540
48NME10.85195619
49BRSK10.85160629
50BRSK20.84850403
51LRRK20.84639441
52INSRR0.84407196
53VRK10.82842065
54GSK3A0.79279651
55MAP3K70.79053388
56PIK3CA0.78552986
57TAF10.78245980
58DYRK30.75426858
59MAPK110.74796036
60PTK60.71935499
61ADRBK20.71317414
62SGK10.66661793
63MAPK130.65861900
64PHKG10.65332467
65PHKG20.65332467
66PDPK10.64516367
67CSNK1E0.64230390
68MKNK20.64152055
69FGFR30.61514612
70MAP2K40.60604842
71TGFBR20.58883944
72ABL20.58493215
73PLK10.58052981
74PRKAA20.57797092
75BCR0.57483529
76EIF2AK10.56971287
77UHMK10.56207733
78ERBB40.55920546
79MARK20.54049059
80NEK60.53573504
81PRKCZ0.52388730
82PTK20.52306217
83MAPK120.51384658
84TNIK0.51121554
85MST40.49766817
86CSNK1A10.49707438
87PRKAA10.49085322
88SIK20.48667216
89PRKCH0.48458658
90RIPK10.46775714
91PLK30.46555629
92DYRK1A0.46443246
93TIE10.46039766
94CDK80.45843913
95MAP2K70.42981683
96NTRK10.42752407
97DAPK20.42226836
98PRKD20.41990748
99DYRK1B0.41963153
100MET0.41888270
101PDK10.41636026
102RPS6KA30.41226960
103CAMK40.40354460
104JAK20.40343825
105PLK20.40037905
106CAMK1D0.39934540
107CSNK1D0.39782513
108PRKACG0.39683850
109PAK30.38939834
110PRKCE0.38284530
111CAMKK10.37782235
112CAMK2B0.36917554
113CAMKK20.35246650
114CDK70.34817366
115CDK50.34750713
116LATS20.34654220
117SRPK10.34136244
118CAMK2A0.33607942
119CAMK10.32832940
120TYK20.32633899
121PRKCG0.32441341
122PTK2B0.31727885
123MUSK0.31665219
124IRAK20.31253053
125BUB10.29981298
126PRKG10.29066531
127BMX0.29022364
128PAK40.28925781
129AURKA0.28856051
130EPHB20.28852116
131PRKDC0.28734512
132MAP3K30.28217999
133PRKCD0.26347920
134NTRK20.24795914
135STK110.24624976
136MINK10.23535012
137PRKCA0.23415540
138CAMK1G0.22444882
139ERBB20.22193458
140PRKCQ0.21828997
141CSK0.21606893
142FGR0.20978680
143MAP3K20.20536922
144MAPK40.20120222
145PBK0.20062319
146PRKACA0.18471090
147IRAK10.18224981
148JAK10.17896950
149FGFR20.17084408
150KSR20.16841993
151PKN10.15983647
152PIK3CG0.15583213
153FER0.15559377
154CAMK2G0.15375659
155IGF1R0.14428726
156SRC0.13633904
157PKN20.13422430
158IRAK30.12036546
159LATS10.11941674
160MAP3K60.09537891
161ROCK10.09148272
162INSR0.08888430
163MAPK150.08806838
164KDR0.08595297
165MAP2K30.08562183
166MAP3K140.08435619

Predicted pathways (KEGG)

RankGene SetZ-score
1Butanoate metabolism_Homo sapiens_hsa006503.30201439
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.28307694
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.18250675
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.08602750
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.07994235
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.00264519
7Propanoate metabolism_Homo sapiens_hsa006402.77262060
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.75022048
9Nitrogen metabolism_Homo sapiens_hsa009102.70120346
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.60342550
11Fatty acid degradation_Homo sapiens_hsa000712.58677385
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.41627715
13Peroxisome_Homo sapiens_hsa041462.39425647
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.34967697
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.33198126
16Tryptophan metabolism_Homo sapiens_hsa003802.31599979
17Primary bile acid biosynthesis_Homo sapiens_hsa001202.20377540
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.14841009
19Fatty acid metabolism_Homo sapiens_hsa012122.07759730
20Pyruvate metabolism_Homo sapiens_hsa006202.05066305
21beta-Alanine metabolism_Homo sapiens_hsa004101.87585824
22Vitamin digestion and absorption_Homo sapiens_hsa049771.85867728
23Arginine biosynthesis_Homo sapiens_hsa002201.83951596
24Bile secretion_Homo sapiens_hsa049761.73542325
25Sulfur metabolism_Homo sapiens_hsa009201.72806593
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.69955407
27Nicotine addiction_Homo sapiens_hsa050331.68422348
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.61935909
29PPAR signaling pathway_Homo sapiens_hsa033201.60978463
30Carbon metabolism_Homo sapiens_hsa012001.47587798
31Histidine metabolism_Homo sapiens_hsa003401.44240919
32Collecting duct acid secretion_Homo sapiens_hsa049661.41087101
33Arginine and proline metabolism_Homo sapiens_hsa003301.39319021
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.34834087
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.28858704
36Glutathione metabolism_Homo sapiens_hsa004801.24387807
37Fatty acid elongation_Homo sapiens_hsa000621.21522629
38Starch and sucrose metabolism_Homo sapiens_hsa005001.19577953
39Steroid biosynthesis_Homo sapiens_hsa001001.19379113
40Phenylalanine metabolism_Homo sapiens_hsa003601.10529970
41Selenocompound metabolism_Homo sapiens_hsa004501.05983060
42Lysine degradation_Homo sapiens_hsa003101.05650512
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.05543252
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05182118
45Biosynthesis of amino acids_Homo sapiens_hsa012301.03360981
46Linoleic acid metabolism_Homo sapiens_hsa005911.02389686
47Complement and coagulation cascades_Homo sapiens_hsa046101.02018561
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01556031
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.01371081
50Chemical carcinogenesis_Homo sapiens_hsa052040.98509233
51Mineral absorption_Homo sapiens_hsa049780.96298787
52Folate biosynthesis_Homo sapiens_hsa007900.93923538
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93661951
54Other glycan degradation_Homo sapiens_hsa005110.93269914
55Glycerolipid metabolism_Homo sapiens_hsa005610.88298139
56GABAergic synapse_Homo sapiens_hsa047270.82743296
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.81652152
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78807392
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.76773997
60Glutamatergic synapse_Homo sapiens_hsa047240.72343703
61Retinol metabolism_Homo sapiens_hsa008300.71850383
62Protein digestion and absorption_Homo sapiens_hsa049740.71321758
63Fructose and mannose metabolism_Homo sapiens_hsa000510.69653681
64Pentose phosphate pathway_Homo sapiens_hsa000300.68636634
65Cocaine addiction_Homo sapiens_hsa050300.68509122
66Basal cell carcinoma_Homo sapiens_hsa052170.66055516
67Lysosome_Homo sapiens_hsa041420.65314536
68Taste transduction_Homo sapiens_hsa047420.63176346
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.62745572
70Amphetamine addiction_Homo sapiens_hsa050310.62065484
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59761790
72Tyrosine metabolism_Homo sapiens_hsa003500.59427891
73Staphylococcus aureus infection_Homo sapiens_hsa051500.59033263
74Huntingtons disease_Homo sapiens_hsa050160.58874815
75ABC transporters_Homo sapiens_hsa020100.58785639
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57098036
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54897060
78Hedgehog signaling pathway_Homo sapiens_hsa043400.53056148
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52949146
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.52525564
81Morphine addiction_Homo sapiens_hsa050320.51823582
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.49623476
83Insulin secretion_Homo sapiens_hsa049110.49301811
84Metabolic pathways_Homo sapiens_hsa011000.49202117
85Sulfur relay system_Homo sapiens_hsa041220.48872389
86Phototransduction_Homo sapiens_hsa047440.47617977
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47616807
88Alcoholism_Homo sapiens_hsa050340.47306533
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46022594
90Renin-angiotensin system_Homo sapiens_hsa046140.43376984
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42255997
92Circadian rhythm_Homo sapiens_hsa047100.42240998
93Cardiac muscle contraction_Homo sapiens_hsa042600.39990646
94Axon guidance_Homo sapiens_hsa043600.39960084
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39123783
96Hippo signaling pathway_Homo sapiens_hsa043900.38178483
97Wnt signaling pathway_Homo sapiens_hsa043100.37316981
98Thyroid hormone synthesis_Homo sapiens_hsa049180.37115732
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37061658
100Serotonergic synapse_Homo sapiens_hsa047260.36497921
101RNA polymerase_Homo sapiens_hsa030200.34609873
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33882017
103Systemic lupus erythematosus_Homo sapiens_hsa053220.32826047
104Dopaminergic synapse_Homo sapiens_hsa047280.32691634
105Caffeine metabolism_Homo sapiens_hsa002320.27641481
106Gastric acid secretion_Homo sapiens_hsa049710.24844335
107Fat digestion and absorption_Homo sapiens_hsa049750.24718957
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.24071985
109Oxidative phosphorylation_Homo sapiens_hsa001900.22844102
110Fatty acid biosynthesis_Homo sapiens_hsa000610.21396419
111Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.17415579
112Insulin resistance_Homo sapiens_hsa049310.15771615
113Arachidonic acid metabolism_Homo sapiens_hsa005900.15487366
114Galactose metabolism_Homo sapiens_hsa000520.14849852
115alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.13759065
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.12989877
117Vitamin B6 metabolism_Homo sapiens_hsa007500.11315059
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.07695185
119Synaptic vesicle cycle_Homo sapiens_hsa047210.06670360
120Sphingolipid metabolism_Homo sapiens_hsa006000.06299173
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.05633984
122Glucagon signaling pathway_Homo sapiens_hsa049220.01600733
123Choline metabolism in cancer_Homo sapiens_hsa052310.01142228
124AMPK signaling pathway_Homo sapiens_hsa041520.00100825
125Parkinsons disease_Homo sapiens_hsa05012-0.0372567
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0253101
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962-0.0232876
128One carbon pool by folate_Homo sapiens_hsa00670-0.0199425
129Vibrio cholerae infection_Homo sapiens_hsa05110-0.0076555

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