SLC13A5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein belonging to the solute carrier family 13 group of proteins. This family member is a sodium-dependent citrate cotransporter that may regulate metabolic processes. Mutations in this gene cause early infantile epileptic encephalopathy 25. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of fibrinolysis (GO:0051918)7.82615352
2regulation of fibrinolysis (GO:0051917)7.70070163
3regulation of protein activation cascade (GO:2000257)7.34975733
4cilium or flagellum-dependent cell motility (GO:0001539)7.11956896
5protein carboxylation (GO:0018214)7.08506053
6peptidyl-glutamic acid carboxylation (GO:0017187)7.08506053
7regulation of complement activation (GO:0030449)7.07139403
8L-phenylalanine catabolic process (GO:0006559)6.94851714
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.94851714
10complement activation, alternative pathway (GO:0006957)6.55017404
11sperm motility (GO:0030317)6.44311508
12acrosome reaction (GO:0007340)6.44147977
13fusion of sperm to egg plasma membrane (GO:0007342)6.29119083
14alanine transport (GO:0032328)6.18768673
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.17732493
16L-phenylalanine metabolic process (GO:0006558)6.17732493
17tooth mineralization (GO:0034505)6.14245895
18intestinal cholesterol absorption (GO:0030299)6.07491829
19very-low-density lipoprotein particle assembly (GO:0034379)6.06525973
20protein-lipid complex remodeling (GO:0034368)6.01315732
21macromolecular complex remodeling (GO:0034367)6.01315732
22plasma lipoprotein particle remodeling (GO:0034369)6.01315732
23blood coagulation, intrinsic pathway (GO:0007597)5.97104054
24high-density lipoprotein particle remodeling (GO:0034375)5.85623766
25plasma lipoprotein particle assembly (GO:0034377)5.80338199
26cholesterol efflux (GO:0033344)5.73626332
27acrosome assembly (GO:0001675)5.55239667
28axonemal dynein complex assembly (GO:0070286)5.50813557
29regulation of plasminogen activation (GO:0010755)5.48835696
30regulation of cholesterol esterification (GO:0010872)5.42518408
31epithelial cilium movement (GO:0003351)5.40067486
32negative regulation of cholesterol transport (GO:0032375)5.36267271
33negative regulation of sterol transport (GO:0032372)5.36267271
34exogenous drug catabolic process (GO:0042738)5.31082996
35motile cilium assembly (GO:0044458)5.30366285
36epoxygenase P450 pathway (GO:0019373)5.27420856
37aromatic amino acid family catabolic process (GO:0009074)5.24359592
38sperm-egg recognition (GO:0035036)5.20642640
39glyoxylate metabolic process (GO:0046487)5.18833394
40epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.12777651
41plasma lipoprotein particle organization (GO:0071827)5.11750103
42drug catabolic process (GO:0042737)5.06740415
43multicellular organism reproduction (GO:0032504)5.01407065
44protein-lipid complex assembly (GO:0065005)4.95951512
45cell wall macromolecule catabolic process (GO:0016998)4.87327736
46cell wall macromolecule metabolic process (GO:0044036)4.87327736
47response to gravity (GO:0009629)4.85971647
48negative regulation of protein activation cascade (GO:2000258)4.84478076
49plasma lipoprotein particle clearance (GO:0034381)4.79239486
50piRNA metabolic process (GO:0034587)4.79139758
51ethanol oxidation (GO:0006069)4.78185055
52regulation of cilium movement (GO:0003352)4.78146312
53plasma membrane fusion (GO:0045026)4.77779475
54binding of sperm to zona pellucida (GO:0007339)4.76399537
55spermatid development (GO:0007286)4.76346512
56positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.74084839
57protein-lipid complex subunit organization (GO:0071825)4.69877855
58omega-hydroxylase P450 pathway (GO:0097267)4.69803144
59imidazole-containing compound metabolic process (GO:0052803)4.66318781
60fibrinolysis (GO:0042730)4.64240189
61cilium movement (GO:0003341)4.58490553
62cell-cell recognition (GO:0009988)4.53994534
63regulation of apoptotic cell clearance (GO:2000425)4.53398729
64protein activation cascade (GO:0072376)4.51539613
65triglyceride homeostasis (GO:0070328)4.46693462
66acylglycerol homeostasis (GO:0055090)4.46693462
67L-serine transport (GO:0015825)4.45466464
68phospholipid efflux (GO:0033700)4.44156886
69acute-phase response (GO:0006953)4.30825856
70serine family amino acid catabolic process (GO:0009071)4.28424893
71gamma-aminobutyric acid transport (GO:0015812)4.25430214
72glutamate metabolic process (GO:0006536)4.23625941
73regulation of humoral immune response (GO:0002920)4.21558794
74male meiosis (GO:0007140)4.17770295
75reproduction (GO:0000003)4.15719814
76negative regulation of astrocyte differentiation (GO:0048712)4.13335943
77regulation of inclusion body assembly (GO:0090083)4.08934953
78complement activation, classical pathway (GO:0006958)4.08491360
79positive regulation of triglyceride lipase activity (GO:0061365)4.05541817
80positive regulation of lipoprotein lipase activity (GO:0051006)4.05541817
81synaptonemal complex organization (GO:0070193)4.05077976
82regulation of triglyceride catabolic process (GO:0010896)3.98635464
83negative regulation of blood coagulation (GO:0030195)3.93984655
84negative regulation of hemostasis (GO:1900047)3.93984655
85cytolysis (GO:0019835)3.93735488
86intestinal absorption (GO:0050892)3.89059702
87negative regulation of lipase activity (GO:0060192)3.88386016
88amino acid import (GO:0043090)3.86751620
89tyrosine metabolic process (GO:0006570)3.82961708
90ethanol metabolic process (GO:0006067)3.81515154
91cellular potassium ion homeostasis (GO:0030007)3.80610515
92complement activation (GO:0006956)3.80419143
93synaptonemal complex assembly (GO:0007130)3.78610691
94negative regulation of complement activation (GO:0045916)3.77589160
95sterol transport (GO:0015918)3.74125876
96cholesterol transport (GO:0030301)3.74125876
97indole-containing compound catabolic process (GO:0042436)3.72811039
98indolalkylamine catabolic process (GO:0046218)3.72811039
99tryptophan catabolic process (GO:0006569)3.72811039
100L-amino acid import (GO:0043092)3.72675104
101lipoprotein metabolic process (GO:0042157)3.72580147
102positive regulation of blood coagulation (GO:0030194)3.69942794
103positive regulation of hemostasis (GO:1900048)3.69942794
104calcium ion-dependent exocytosis (GO:0017156)3.69807687
105cholesterol homeostasis (GO:0042632)3.66546993
106positive regulation of fatty acid biosynthetic process (GO:0045723)3.65793941
107serine transport (GO:0032329)3.64857306
108bile acid biosynthetic process (GO:0006699)3.64214495
109aromatic amino acid family metabolic process (GO:0009072)3.60741417
110negative regulation of coagulation (GO:0050819)3.60408810
111sterol homeostasis (GO:0055092)3.60180328
112drug metabolic process (GO:0017144)3.59432735
113cartilage condensation (GO:0001502)3.58572608
114cell aggregation (GO:0098743)3.58572608
115bile acid metabolic process (GO:0008206)3.58551333
116alpha-amino acid catabolic process (GO:1901606)3.58420601
117opsonization (GO:0008228)3.57395276
118single fertilization (GO:0007338)3.54419166
119ventricular system development (GO:0021591)3.50879024
120disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.50581596
121killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.50581596
122sodium ion export (GO:0071436)3.50099187
123oxidative demethylation (GO:0070989)3.49721342
124glycine metabolic process (GO:0006544)3.47758295
125biomineral tissue development (GO:0031214)3.43536561
126negative regulation of wound healing (GO:0061045)3.42924243
127diacylglycerol metabolic process (GO:0046339)3.37133966
128cellular glucuronidation (GO:0052695)3.36179323
129regulation of bile acid biosynthetic process (GO:0070857)3.35511559
130proline metabolic process (GO:0006560)3.34794942
131positive regulation of coagulation (GO:0050820)3.31739142
132G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.31133739
133arginine metabolic process (GO:0006525)3.29093825
134low-density lipoprotein particle remodeling (GO:0034374)3.28854700
135proline transport (GO:0015824)3.28309045
136organic cation transport (GO:0015695)3.26462508
137glucuronate metabolic process (GO:0019585)3.24320371
138uronic acid metabolic process (GO:0006063)3.24320371
139sperm capacitation (GO:0048240)3.22877801
140* C4-dicarboxylate transport (GO:0015740)3.21811574
141acute inflammatory response (GO:0002526)3.21165156
142negative regulation of inclusion body assembly (GO:0090084)3.18811393
143regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.15990083
144cellular response to cholesterol (GO:0071397)3.13998987
145cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.12793299
146cellular amino acid catabolic process (GO:0009063)3.12151451
147flavonoid metabolic process (GO:0009812)3.11007521
148positive regulation of extracellular matrix organization (GO:1903055)3.09579432
149negative regulation of smoothened signaling pathway (GO:0045879)3.06164105
150fertilization (GO:0009566)3.00269968
151neurotransmitter-gated ion channel clustering (GO:0072578)3.00263898
152spermatogenesis (GO:0007283)2.98326982
153regulation of response to osmotic stress (GO:0047484)2.98014254
154male gamete generation (GO:0048232)2.96665660
155regulation of microtubule-based movement (GO:0060632)2.96654010
156cellular sodium ion homeostasis (GO:0006883)2.94328510
157positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.89965183
158notochord development (GO:0030903)2.85860620
159triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.79117541
160cell recognition (GO:0008037)2.78913676
161cell communication by electrical coupling (GO:0010644)2.78144332
162germ cell development (GO:0007281)2.77501248
163chaperone-mediated protein complex assembly (GO:0051131)2.76606644
164replacement ossification (GO:0036075)2.75595240
165endochondral ossification (GO:0001958)2.75595240
166alpha-linolenic acid metabolic process (GO:0036109)2.75206631
167gamete generation (GO:0007276)2.74519436
168hormone catabolic process (GO:0042447)2.72970084
169cerebellar granule cell differentiation (GO:0021707)2.69005012
170DNA methylation involved in gamete generation (GO:0043046)2.66945388
171chondroitin sulfate catabolic process (GO:0030207)2.66307291
172regulation of astrocyte differentiation (GO:0048710)2.64925811
173cellular response to sterol (GO:0036315)2.64469841
174neurotransmitter uptake (GO:0001504)2.64040339
175left/right pattern formation (GO:0060972)2.62792986
176fructose metabolic process (GO:0006000)2.61700301
177cellular process involved in reproduction in multicellular organism (GO:0022412)2.60916082
178chondrocyte development (GO:0002063)2.59608115
179atrial cardiac muscle cell action potential (GO:0086014)2.58734224
180glutamate receptor signaling pathway (GO:0007215)2.57427337
181negative regulation of response to reactive oxygen species (GO:1901032)2.54897708
182peptidyl-glutamic acid modification (GO:0018200)2.50941323
183negative regulation of sodium ion transport (GO:0010766)2.50603716
184potassium ion import (GO:0010107)2.50358482
185negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.49426399
186male meiosis I (GO:0007141)2.49122428
187locomotory exploration behavior (GO:0035641)2.47623480
188glutamate secretion (GO:0014047)2.47116844
189regulation of extracellular matrix organization (GO:1903053)2.46662441
190negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.45731236
191acidic amino acid transport (GO:0015800)2.45062346
192purine nucleotide transport (GO:0015865)2.44982571
193adenine nucleotide transport (GO:0051503)2.44814413
194dermatan sulfate biosynthetic process (GO:0030208)2.44408877
195reverse cholesterol transport (GO:0043691)2.44328809
196positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.43940526

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.90792298
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.85071872
3EGR1_23403033_ChIP-Seq_LIVER_Mouse4.67335518
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.03713729
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.90901247
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.80745829
7CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.34378472
8FOXA2_19822575_ChIP-Seq_HepG2_Human3.05618890
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.03628985
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.85128640
11* HNF4A_19822575_ChIP-Seq_HepG2_Human2.57696287
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.43070768
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.40956039
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.32982714
15CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.24088765
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.23382025
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.00641313
18GBX2_23144817_ChIP-Seq_PC3_Human1.94729229
19REST_21632747_ChIP-Seq_MESCs_Mouse1.93318411
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82162863
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.74212561
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.74084776
23* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.63788908
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61060434
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.54522054
26IGF1R_20145208_ChIP-Seq_DFB_Human1.54145260
27* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.53454416
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.51688363
29ESR1_15608294_ChIP-ChIP_MCF-7_Human1.50572508
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.48477143
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.48390539
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.48096084
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.46914332
34* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.45094255
35AR_21572438_ChIP-Seq_LNCaP_Human1.44727330
36* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.44534608
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42820358
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.39376333
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38377098
40SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.37277962
41KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.33626890
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32820813
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32820813
44ELK4_26923725_Chip-Seq_MESODERM_Mouse1.31104588
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29924541
46DROSHA_22980978_ChIP-Seq_HELA_Human1.27914943
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.27662171
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.27477217
49RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.26246308
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26200241
51MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24150097
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.24000048
53TCF4_18268006_ChIP-ChIP_LS174T_Human1.23032162
54EZH2_18974828_ChIP-Seq_MESCs_Mouse1.22115282
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.22115282
56ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19508543
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18568768
58JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18090857
59* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18080738
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.17975507
61* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17730832
62TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17582783
63BCAT_22108803_ChIP-Seq_LS180_Human1.17325618
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17027294
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.16918338
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16475554
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16371291
68SMAD4_21799915_ChIP-Seq_A2780_Human1.16206537
69GATA4_25053715_ChIP-Seq_YYC3_Human1.16140719
70TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.16060784
71REST_18959480_ChIP-ChIP_MESCs_Mouse1.14281350
72ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14052067
73MYC_19829295_ChIP-Seq_ESCs_Human1.12804759
74FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.12530123
75GATA1_26923725_Chip-Seq_HPCs_Mouse1.11926285
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11796701
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11080143
78CBP_20019798_ChIP-Seq_JUKART_Human1.11080143
79EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10506662
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09760378
81NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.08953735
82KAP1_22055183_ChIP-Seq_ESCs_Mouse1.08676040
83HTT_18923047_ChIP-ChIP_STHdh_Human1.08652982
84RING1B_27294783_Chip-Seq_ESCs_Mouse1.08224679
85FLI1_27457419_Chip-Seq_LIVER_Mouse1.06319861
86E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06264468
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.06133107
88BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05097858
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04285534
90IRF1_19129219_ChIP-ChIP_H3396_Human1.04243068
91AR_25329375_ChIP-Seq_VCAP_Human1.03978098
92RAC3_21632823_ChIP-Seq_H3396_Human1.03477502
93PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02661547
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02303191
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.01335446
96NANOG_19829295_ChIP-Seq_ESCs_Human1.00655184
97SOX2_19829295_ChIP-Seq_ESCs_Human1.00655184
98RXR_22108803_ChIP-Seq_LS180_Human1.00448040
99NFE2_27457419_Chip-Seq_LIVER_Mouse0.99711871
100P300_19829295_ChIP-Seq_ESCs_Human0.99038945
101ERA_21632823_ChIP-Seq_H3396_Human0.98156028
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97989812
103OCT4_20526341_ChIP-Seq_ESCs_Human0.97901937
104TBL1_22424771_ChIP-Seq_293T_Human0.97887091
105RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96754628
106TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96669940
107POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96335425
108VDR_22108803_ChIP-Seq_LS180_Human0.95964512
109PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95906274
110* LXR_22158963_ChIP-Seq_LIVER_Mouse0.95758082
111WDR5_24793694_ChIP-Seq_LNCAP_Human0.95467270
112ZNF274_21170338_ChIP-Seq_K562_Hela0.95369031
113AR_20517297_ChIP-Seq_VCAP_Human0.95247694
114ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95148561
115PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94567918
116NCOR_22424771_ChIP-Seq_293T_Human0.94003673
117FOXH1_21741376_ChIP-Seq_EPCs_Human0.93898433
118* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92623245
119AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92099198
120SMAD4_21741376_ChIP-Seq_EPCs_Human0.92069886
121MYC_27129775_Chip-Seq_CORNEA_Mouse0.92025017
122IKZF1_21737484_ChIP-ChIP_HCT116_Human0.91958296
123TAF2_19829295_ChIP-Seq_ESCs_Human0.91370038
124TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91367526
125STAT3_23295773_ChIP-Seq_U87_Human0.91078610
126RNF2_27304074_Chip-Seq_NSC_Mouse0.90815194
127TAL1_26923725_Chip-Seq_HPCs_Mouse0.88705283
128CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.88601900
129CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88489378
130SOX2_21211035_ChIP-Seq_LN229_Gbm0.87790429
131TCF4_23295773_ChIP-Seq_U87_Human0.87774867
132SMAD_19615063_ChIP-ChIP_OVARY_Human0.87528053
133TCF4_22108803_ChIP-Seq_LS180_Human0.87217600
134TAF15_26573619_Chip-Seq_HEK293_Human0.87154419
135CDX2_20551321_ChIP-Seq_CACO-2_Human0.87090979
136SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87030250
137TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86024348
138RXRA_24833708_ChIP-Seq_LIVER_Mouse0.85776181
139SMAD3_21741376_ChIP-Seq_ESCs_Human0.85478332
140ZNF217_24962896_ChIP-Seq_MCF-7_Human0.85144590
141FOXH1_21741376_ChIP-Seq_ESCs_Human0.85070870
142RARB_27405468_Chip-Seq_BRAIN_Mouse0.84709978
143BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.83962707
144GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83929285
145EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.83628167
146RAD21_21589869_ChIP-Seq_MESCs_Mouse0.82963282
147KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.82955236
148CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82183838
149CEBPB_22108803_ChIP-Seq_LS180_Human0.81838722
150EZH2_27294783_Chip-Seq_NPCs_Mouse0.80643039
151GATA3_21878914_ChIP-Seq_MCF-7_Human0.80480844
152SOX2_21211035_ChIP-Seq_LN229_Human0.80322931
153NANOG_20526341_ChIP-Seq_ESCs_Human0.80252910
154SMAD1_18555785_Chip-Seq_ESCs_Mouse0.79430221
155FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78999771
156ER_23166858_ChIP-Seq_MCF-7_Human0.78800464
157TP53_16413492_ChIP-PET_HCT116_Human0.78158558
158EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.77676224
159CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.77376993
160FOXA1_25329375_ChIP-Seq_VCAP_Human0.77095837
161FOXA1_27270436_Chip-Seq_PROSTATE_Human0.77095837
162P53_22127205_ChIP-Seq_FIBROBLAST_Human0.75881439
163BMI1_23680149_ChIP-Seq_NPCS_Mouse0.74690054
164* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.73877058
165OCT4_18555785_Chip-Seq_ESCs_Mouse0.72542464
166P53_21459846_ChIP-Seq_SAOS-2_Human0.72516036
167STAT3_18555785_Chip-Seq_ESCs_Mouse0.71720051

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.07873946
2MP0003195_calcinosis5.55449413
3MP0005365_abnormal_bile_salt4.85661810
4MP0008875_abnormal_xenobiotic_pharmacok4.84369500
5MP0005085_abnormal_gallbladder_physiolo4.42584901
6MP0003122_maternal_imprinting3.91828996
7MP0001542_abnormal_bone_strength3.79351112
8MP0001666_abnormal_nutrient_absorption3.36481685
9MP0003136_yellow_coat_color3.25138379
10MP0002653_abnormal_ependyma_morphology3.16209896
11MP0003252_abnormal_bile_duct3.06415945
12MP0002254_reproductive_system_inflammat2.61720284
13MP0003698_abnormal_male_reproductive2.52698026
14MP0003646_muscle_fatigue2.41738626
15MP0004185_abnormal_adipocyte_glucose2.21858550
16MP0009384_cardiac_valve_regurgitation2.19771714
17MP0004859_abnormal_synaptic_plasticity2.15027847
18MP0009046_muscle_twitch2.14036721
19MP0003123_paternal_imprinting2.11380598
20MP0003690_abnormal_glial_cell2.08596491
21MP0004885_abnormal_endolymph2.06240428
22MP0001929_abnormal_gametogenesis2.05245888
23MP0003329_amyloid_beta_deposits2.01708134
24MP0004134_abnormal_chest_morphology1.98692160
25MP0002282_abnormal_trachea_morphology1.96321588
26MP0004858_abnormal_nervous_system1.93616000
27MP0006292_abnormal_olfactory_placode1.91605033
28MP0002876_abnormal_thyroid_physiology1.86845839
29MP0005623_abnormal_meninges_morphology1.86518897
30MP0003868_abnormal_feces_composition1.85360947
31MP0002138_abnormal_hepatobiliary_system1.80194822
32MP0009250_abnormal_appendicular_skeleto1.78234302
33MP0000566_synostosis1.77986427
34MP0005670_abnormal_white_adipose1.74120165
35MP0005408_hypopigmentation1.72501958
36MP0003635_abnormal_synaptic_transmissio1.71019184
37MP0004270_analgesia1.70121687
38MP0002118_abnormal_lipid_homeostasis1.67641091
39MP0003121_genomic_imprinting1.62182662
40MP0005666_abnormal_adipose_tissue1.60454148
41MP0009780_abnormal_chondrocyte_physiolo1.54180516
42MP0005171_absent_coat_pigmentation1.53006473
43MP0005503_abnormal_tendon_morphology1.51686154
44MP0000609_abnormal_liver_physiology1.50637008
45MP0001486_abnormal_startle_reflex1.50404271
46MP0005646_abnormal_pituitary_gland1.50116854
47MP0000163_abnormal_cartilage_morphology1.48046758
48MP0010368_abnormal_lymphatic_system1.47501649
49MP0002572_abnormal_emotion/affect_behav1.45819486
50MP0008877_abnormal_DNA_methylation1.45458523
51MP0005423_abnormal_somatic_nervous1.43799259
52MP0003806_abnormal_nucleotide_metabolis1.42662577
53MP0002064_seizures1.41837136
54MP0002115_abnormal_skeleton_extremities1.40814602
55MP0002063_abnormal_learning/memory/cond1.38780623
56MP0002089_abnormal_postnatal_growth/wei1.36967658
57MP0002161_abnormal_fertility/fecundity1.33560306
58MP0003633_abnormal_nervous_system1.32874141
59MP0005084_abnormal_gallbladder_morpholo1.32182881
60MP0002132_abnormal_respiratory_system1.31737248
61MP0000432_abnormal_head_morphology1.31676141
62MP0009745_abnormal_behavioral_response1.30861217
63MP0001764_abnormal_homeostasis1.30568337
64MP0002896_abnormal_bone_mineralization1.29696827
65MP0001440_abnormal_grooming_behavior1.28368103
66MP0002210_abnormal_sex_determination1.26852510
67MP0004019_abnormal_vitamin_homeostasis1.26692340
68MP0000049_abnormal_middle_ear1.22756786
69MP0010030_abnormal_orbit_morphology1.21397948
70MP0005377_hearing/vestibular/ear_phenot1.19122229
71MP0003878_abnormal_ear_physiology1.19122229
72MP0001984_abnormal_olfaction1.16415766
73MP0003880_abnormal_central_pattern1.15708600
74MP0003279_aneurysm1.13483124
75MP0002938_white_spotting1.11992556
76MP0000604_amyloidosis1.10476943
77MP0002998_abnormal_bone_remodeling1.09949157
78MP0002249_abnormal_larynx_morphology1.09241220
79MP0001145_abnormal_male_reproductive1.08930882
80MP0001299_abnormal_eye_distance/1.08463255
81MP0002108_abnormal_muscle_morphology1.08171274
82MP0004272_abnormal_basement_membrane1.07225934
83MP0005636_abnormal_mineral_homeostasis1.07173932
84MP0000639_abnormal_adrenal_gland1.07160825
85MP0003879_abnormal_hair_cell1.05819998
86MP0001502_abnormal_circadian_rhythm1.04871815
87MP0009697_abnormal_copulation1.04259463
88MP0003631_nervous_system_phenotype1.03520955
89MP0001968_abnormal_touch/_nociception1.03013596
90MP0002116_abnormal_craniofacial_bone1.02959595
91MP0005508_abnormal_skeleton_morphology1.02289916
92MP0002160_abnormal_reproductive_system1.00778809
93MP0004233_abnormal_muscle_weight0.98089381
94MP0005167_abnormal_blood-brain_barrier0.97795770
95MP0001963_abnormal_hearing_physiology0.95139762
96MP0002736_abnormal_nociception_after0.94629527
97MP0002109_abnormal_limb_morphology0.94624426
98MP0002139_abnormal_hepatobiliary_system0.93801931
99MP0005379_endocrine/exocrine_gland_phen0.92867223
100MP0000762_abnormal_tongue_morphology0.92815052
101MP0003935_abnormal_craniofacial_develop0.90720620
102MP0003567_abnormal_fetal_cardiomyocyte0.90292743
103MP0000653_abnormal_sex_gland0.90174208
104MP0008569_lethality_at_weaning0.89954326
105MP0009642_abnormal_blood_homeostasis0.89625167
106MP0001986_abnormal_taste_sensitivity0.89084854
107MP0003011_delayed_dark_adaptation0.88450333
108MP0003634_abnormal_glial_cell0.88277510
109MP0003172_abnormal_lysosome_physiology0.86861514
110MP0002734_abnormal_mechanical_nocicepti0.86851141
111MP0003191_abnormal_cellular_cholesterol0.86277273
112MP0010329_abnormal_lipoprotein_level0.85442444
113MP0002909_abnormal_adrenal_gland0.85152356
114MP0001661_extended_life_span0.83956015
115MP0003075_altered_response_to0.83280417
116MP0001915_intracranial_hemorrhage0.82904069
117MP0004142_abnormal_muscle_tone0.82047776
118MP0005360_urolithiasis0.81994690
119MP0005332_abnormal_amino_acid0.81420683
120MP0000778_abnormal_nervous_system0.80578412
121MP0008872_abnormal_physiological_respon0.80493666
122MP0000598_abnormal_liver_morphology0.80483048
123MP0003283_abnormal_digestive_organ0.80328285
124MP0009643_abnormal_urine_homeostasis0.79701889
125MP0005319_abnormal_enzyme/_coenzyme0.79136911
126MP0002272_abnormal_nervous_system0.78793102
127MP0002113_abnormal_skeleton_development0.78732521
128MP0002067_abnormal_sensory_capabilities0.78629664
129MP0000462_abnormal_digestive_system0.78019175
130MP0003632_abnormal_nervous_system0.77528125
131MP0005647_abnormal_sex_gland0.77068346
132MP0002078_abnormal_glucose_homeostasis0.74746182
133MP0004133_heterotaxia0.74506879
134MP0004043_abnormal_pH_regulation0.74113968
135MP0001293_anophthalmia0.74103701
136MP0005448_abnormal_energy_balance0.73915157
137MP0000751_myopathy0.72034624
138MP0005551_abnormal_eye_electrophysiolog0.71057757
139MP0002557_abnormal_social/conspecific_i0.70502041
140MP0002295_abnormal_pulmonary_circulatio0.70214954
141MP0009840_abnormal_foam_cell0.69661326
142MP0001324_abnormal_eye_pigmentation0.68864665
143MP0003953_abnormal_hormone_level0.68583886
144MP0005389_reproductive_system_phenotype0.68543450
145MP0000026_abnormal_inner_ear0.68267770
146MP0002152_abnormal_brain_morphology0.67763979
147MP0002638_abnormal_pupillary_reflex0.67181541
148MP0002009_preneoplasia0.66447242
149MP0001529_abnormal_vocalization0.66147805
150MP0003755_abnormal_palate_morphology0.65921834
151MP0001756_abnormal_urination0.64351640
152MP0005195_abnormal_posterior_eye0.59696820
153MP0005220_abnormal_exocrine_pancreas0.55974186
154MP0004742_abnormal_vestibular_system0.53796805
155MP0003718_maternal_effect0.52798827
156MP0001270_distended_abdomen0.52553532
157MP0003315_abnormal_perineum_morphology0.52194809
158MP0003890_abnormal_embryonic-extraembry0.51234338
159MP0005584_abnormal_enzyme/coenzyme_acti0.50504639
160MP0002234_abnormal_pharynx_morphology0.49781800
161MP0003942_abnormal_urinary_system0.49102268
162MP0003638_abnormal_response/metabolism_0.48104759
163MP0005645_abnormal_hypothalamus_physiol0.47376978
164MP0005376_homeostasis/metabolism_phenot0.47244398
165MP0005395_other_phenotype0.46468657
166MP0003119_abnormal_digestive_system0.45856524
167MP0002971_abnormal_brown_adipose0.44633356
168MP0000678_abnormal_parathyroid_gland0.43852939
169MP0001286_abnormal_eye_development0.43310180
170MP0002233_abnormal_nose_morphology0.42537685

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)8.77210074
2Complement deficiency (HP:0004431)7.60551515
3Hypobetalipoproteinemia (HP:0003563)7.14358919
4Joint hemorrhage (HP:0005261)6.89348530
5Abnormality of aromatic amino acid family metabolism (HP:0004338)6.52645262
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.14171574
7Absent/shortened dynein arms (HP:0200106)5.98164355
8Dynein arm defect of respiratory motile cilia (HP:0012255)5.98164355
9Abnormality of complement system (HP:0005339)5.47553127
10Abnormality of monocarboxylic acid metabolism (HP:0010996)5.36495638
11Amelogenesis imperfecta (HP:0000705)5.29382781
12Metaphyseal cupping (HP:0003021)5.29082645
13Epiphyseal dysplasia (HP:0002656)5.03117288
14Spontaneous abortion (HP:0005268)4.96124795
15Xanthomatosis (HP:0000991)4.93941915
16Abnormality of the common coagulation pathway (HP:0010990)4.90142773
17Glomerulonephritis (HP:0000099)4.50234628
18Systemic lupus erythematosus (HP:0002725)4.47875607
19Conjugated hyperbilirubinemia (HP:0002908)4.47626855
20Small epiphyses (HP:0010585)4.47265017
21Irregular epiphyses (HP:0010582)4.46346216
22Hypolipoproteinemia (HP:0010981)4.24837961
23Abnormal respiratory motile cilium physiology (HP:0012261)4.11638364
24Hyperlipoproteinemia (HP:0010980)3.99890399
25Abnormal respiratory epithelium morphology (HP:0012253)3.83351459
26Abnormal respiratory motile cilium morphology (HP:0005938)3.83351459
27Aplasia involving bones of the upper limbs (HP:0009823)3.69372414
28Aplasia of the phalanges of the hand (HP:0009802)3.69372414
29Aplasia involving bones of the extremities (HP:0009825)3.69372414
30Cupped ribs (HP:0000887)3.67433502
31Hyperglycinemia (HP:0002154)3.64263320
32Epidermoid cyst (HP:0200040)3.62801354
33Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.61303208
34Abnormal tarsal ossification (HP:0008369)3.59392762
35Intrahepatic cholestasis (HP:0001406)3.59139511
36Hypercholesterolemia (HP:0003124)3.56584062
37Vitreoretinal degeneration (HP:0000655)3.49670735
38Hypoplastic ischia (HP:0003175)3.47366411
39Rhinitis (HP:0012384)3.46948163
40Neonatal short-limb short stature (HP:0008921)3.44200476
41Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.39890089
42Abnormality of the ischium (HP:0003174)3.17949557
43Abnormal ciliary motility (HP:0012262)3.17189612
44Genu varum (HP:0002970)3.15207859
45Abnormality of the vertebral endplates (HP:0005106)3.06120431
46Hemiparesis (HP:0001269)3.06003701
47Flattened epiphyses (HP:0003071)3.04182323
48Mild short stature (HP:0003502)3.04104193
49Menorrhagia (HP:0000132)3.02576176
50Short femoral neck (HP:0100864)3.01480670
51Irregular vertebral endplates (HP:0003301)3.00501809
52Enlarged kidneys (HP:0000105)2.98154534
53Hypoalphalipoproteinemia (HP:0003233)2.94872845
54Hemorrhage of the eye (HP:0011885)2.92038541
55Abnormality of the intrinsic pathway (HP:0010989)2.89544622
56Abnormality of glycine metabolism (HP:0010895)2.87588740
57Abnormality of serine family amino acid metabolism (HP:0010894)2.87588740
58Vascular calcification (HP:0004934)2.83416881
59Gingival bleeding (HP:0000225)2.75553750
60Onycholysis (HP:0001806)2.74067097
61Delayed epiphyseal ossification (HP:0002663)2.68496201
62Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.68467547
63Acanthocytosis (HP:0001927)2.68296222
64Megalencephaly (HP:0001355)2.65020837
65Flat capital femoral epiphysis (HP:0003370)2.63517708
66Recurrent gram-negative bacterial infections (HP:0005420)2.61581405
67Arthropathy (HP:0003040)2.61000143
68Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.60904245
69Absent epiphyses (HP:0010577)2.60904245
70Chronic bronchitis (HP:0004469)2.58641714
71Flat acetabular roof (HP:0003180)2.57598332
72Hyperglycinuria (HP:0003108)2.56570517
73Metaphyseal dysplasia (HP:0100255)2.54132360
74Broad alveolar ridges (HP:0000187)2.53523193
75Fat malabsorption (HP:0002630)2.52762932
76Thrombophlebitis (HP:0004418)2.51939896
77Nephritis (HP:0000123)2.51789532
78Infertility (HP:0000789)2.50116219
79Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.47045440
80Abnormality of femoral epiphyses (HP:0006499)2.47045440
81Delayed CNS myelination (HP:0002188)2.46979054
82Generalized aminoaciduria (HP:0002909)2.46019894
83Short ribs (HP:0000773)2.44956796
84Facial shape deformation (HP:0011334)2.43290418
85Potter facies (HP:0002009)2.43290418
86Osteoarthritis (HP:0002758)2.42490597
87Hepatoblastoma (HP:0002884)2.38028926
88Purpura (HP:0000979)2.35771588
89Mixed hearing impairment (HP:0000410)2.35186225
90Cardiovascular calcification (HP:0011915)2.34210569
91Neurofibrillary tangles (HP:0002185)2.33894752
92Vertebral clefting (HP:0008428)2.33401047
93Abnormality of the pubic bones (HP:0003172)2.32830991
94Relative macrocephaly (HP:0004482)2.30147863
95Abnormality of the nasal septum (HP:0000419)2.27840482
96Abnormality of the epiphysis of the femoral head (HP:0010574)2.27790264
97Abnormality of methionine metabolism (HP:0010901)2.26318160
98Absent frontal sinuses (HP:0002688)2.25533122
99Rickets (HP:0002748)2.24149408
100Abnormality of the phalanges of the 2nd finger (HP:0009541)2.24015484
101Limited elbow extension (HP:0001377)2.22231190
102Fibular hypoplasia (HP:0003038)2.21778161
103Abnormality of the middle phalanges of the toes (HP:0010183)2.21632075
104Pancreatic islet-cell hyperplasia (HP:0004510)2.21566276
105Abnormality of pyrimidine metabolism (HP:0004353)2.21517077
106Ulnar bowing (HP:0003031)2.21462120
107Abnormal vertebral ossification (HP:0100569)2.16224391
108Aplasia/hypoplasia of the femur (HP:0005613)2.15121584
109Hepatocellular carcinoma (HP:0001402)2.14903939
110Hemiplegia (HP:0002301)2.14039734
111Abnormality of the lower motor neuron (HP:0002366)2.13820911
112Poikilocytosis (HP:0004447)2.12811110
113Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.12561510
114Abnormality of dentin (HP:0010299)2.11989686
115Abnormality of the femoral head (HP:0003368)2.11638291
116Coxa vara (HP:0002812)2.11407582
117Widely patent fontanelles and sutures (HP:0004492)2.10201525
118Hypoglycemic coma (HP:0001325)2.08233617
119Clumsiness (HP:0002312)2.08148495
120Abnormality of glutamine family amino acid metabolism (HP:0010902)2.08132413
121Waddling gait (HP:0002515)2.08087223
122Abnormality of serum amino acid levels (HP:0003112)2.06066495
123Hypothermia (HP:0002045)2.05243195
124Pigmentary retinal degeneration (HP:0001146)2.04421322
125Abnormality of the dental pulp (HP:0006479)2.04118739
126Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.02145685
127Microglossia (HP:0000171)2.01192874
128Abnormal foot bone ossification (HP:0010675)2.00340803
129Ketosis (HP:0001946)2.00104057
130Deep venous thrombosis (HP:0002625)10.2829350
131Protuberant abdomen (HP:0001538)1.98276091
132Short middle phalanx of finger (HP:0005819)1.97948535
133Mitral stenosis (HP:0001718)1.96785499
134Abnormality of urine glucose concentration (HP:0011016)1.96166096
135Glycosuria (HP:0003076)1.96166096
136Fair hair (HP:0002286)1.95736728
137Protrusio acetabuli (HP:0003179)1.94958658
138Nephronophthisis (HP:0000090)1.94477135
139Hypoplastic pelvis (HP:0008839)1.93802698
140Platyspondyly (HP:0000926)1.92930194
141Abnormality of aspartate family amino acid metabolism (HP:0010899)1.91933477
142Diastasis recti (HP:0001540)1.91881509
143Bile duct proliferation (HP:0001408)1.91660019
144Abnormal biliary tract physiology (HP:0012439)1.91660019
145Osteomalacia (HP:0002749)1.90331264
146Abnormality of the dental root (HP:0006486)1.90324104
147Taurodontia (HP:0000679)1.90324104
148Abnormality of permanent molar morphology (HP:0011071)1.90324104
149Hyperammonemia (HP:0001987)1.90062285
150Rhizomelia (HP:0008905)1.89531304
151Abnormality of the proximal phalanges of the hand (HP:0009834)1.88421527
152Short hallux (HP:0010109)1.88002383
153Supernumerary spleens (HP:0009799)1.86482180
154Vaginal fistula (HP:0004320)1.85523808
155Focal motor seizures (HP:0011153)1.84063525
156Cerebral inclusion bodies (HP:0100314)1.83544401
157Abnormality of molar morphology (HP:0011070)1.83152962
158Abnormality of molar (HP:0011077)1.83152962
159Stillbirth (HP:0003826)1.82348285
160Increased serum pyruvate (HP:0003542)1.82342630
161Neoplasm of the liver (HP:0002896)1.78618533
162Skin nodule (HP:0200036)1.78023969
163Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.76861708
164Abnormality of the vitreous humor (HP:0004327)1.76834140
165Bell-shaped thorax (HP:0001591)1.76610189
166Hypophosphatemic rickets (HP:0004912)1.75937292
167Metaphyseal irregularity (HP:0003025)1.75763321
168Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.75583275
169Hyperphosphaturia (HP:0003109)1.75437049
170Abnormality of the middle phalanges of the hand (HP:0009833)1.75388703
171Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.74614299
172Abnormality of carpal bone ossification (HP:0006257)1.74553408
173Pulmonary embolism (HP:0002204)1.73677385
174Flared metaphyses (HP:0003015)1.72320413
175Micromelia (HP:0002983)1.70207430
176Broad long bones (HP:0005622)1.70165343
177Renal cortical cysts (HP:0000803)1.67479485
178Retinal atrophy (HP:0001105)1.66630298
179Abnormality of sulfur amino acid metabolism (HP:0004339)1.66611813
180Decreased central vision (HP:0007663)1.62098549
181Chronic hepatic failure (HP:0100626)1.61919735
182Bifid scrotum (HP:0000048)1.59569878
183Megaloblastic anemia (HP:0001889)1.58683364
184Abnormality of proline metabolism (HP:0010907)1.57950861
185Hydroxyprolinuria (HP:0003080)1.57950861
186Gout (HP:0001997)1.57799096
187Hypoplasia of the capital femoral epiphysis (HP:0003090)1.56883776
188Abnormality of the wing of the ilium (HP:0011867)1.55424441
189Abnormality of alanine metabolism (HP:0010916)1.53037999
190Hyperalaninemia (HP:0003348)1.53037999
191Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.53037999
192Submucous cleft hard palate (HP:0000176)1.52619395
193Metabolic acidosis (HP:0001942)1.49358560

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK44.91184363
2PDK34.91184363
3FGFR44.90951509
4PRKD34.80228119
5EPHA44.16894378
6FGFR33.68133385
7PDK23.49575032
8DDR23.28910768
9PIK3CA3.01397254
10FRK2.76152369
11ICK2.75685274
12NTRK22.72124943
13TNIK2.18304657
14SIK22.17824148
15LMTK22.16390124
16PHKG12.09002229
17PHKG22.09002229
18TESK12.07097681
19TYRO31.97177582
20MAP4K21.94481251
21CASK1.82790760
22GRK11.81129148
23ADRBK21.78635522
24NTRK31.77942841
25AKT31.77614067
26TRIB31.72502261
27WNK31.67696344
28BMPR1B1.57089615
29PNCK1.56645318
30TAOK31.51688761
31STK381.47054614
32BCKDK1.44526319
33SIK11.44479584
34DYRK1B1.44368772
35PRKAA21.44272199
36INSRR1.44264507
37ERBB21.40909494
38PINK11.39919905
39STK38L1.37501181
40DYRK21.33676880
41PTK2B1.26663599
42MAP3K41.23735846
43NUAK11.20714533
44FGFR21.15798261
45MAPK71.14655711
46MAP2K71.11868504
47PRKCG1.09847833
48ZAK1.04068768
49MAPK121.03947715
50BCR1.03428144
51MUSK0.95757846
52DAPK20.92663310
53PAK60.90604921
54STK390.89901326
55MAPK110.89313159
56PRKCZ0.88466318
57MKNK20.87466326
58CSNK1E0.85795057
59MAP2K40.83747575
60WNK40.82575486
61SGK20.81867439
62PRKG20.78251311
63PLK20.76778631
64SGK30.74568700
65ITK0.71475594
66NME10.67939146
67PDK10.66381597
68TIE10.65692346
69CAMKK10.64715502
70CSNK1D0.63384030
71MAP2K60.63263849
72SGK2230.62655000
73SGK4940.62655000
74STK240.61041581
75IGF1R0.60840149
76CAMKK20.60497494
77TAOK20.60434155
78WNK10.60187369
79STK160.59963325
80TGFBR20.58598783
81MATK0.58512923
82MAP3K110.57789515
83MAP3K30.56727406
84NEK60.56020944
85FGFR10.55324979
86ADRBK10.55090562
87BMX0.54758783
88CSNK1A10.54307790
89ERBB40.54257489
90MAPK130.53787580
91STK30.53285397
92CDK50.53224158
93NTRK10.52081940
94MINK10.50347202
95BRSK20.50210620
96PRKACG0.50048957
97CAMK2A0.49615842
98EPHA20.49392462
99LATS20.49340341
100MST40.49309894
101TLK10.48885546
102CSNK2A10.48707242
103PRKAA10.48008679
104CAMK1G0.47883338
105DYRK1A0.47148161
106CSNK2A20.46935540
107PAK30.46409317
108CDK90.45662540
109PBK0.45638205
110FGR0.45199314
111MAPKAPK30.44680318
112MARK10.44363127
113PDPK10.43843873
114ACVR1B0.43246136
115CSNK1G10.43127948
116PDGFRA0.42309709
117BRSK10.41985966
118MAP3K70.41925019
119NEK20.41534083
120PRKACB0.41048152
121CAMK40.41000055
122CSNK1A1L0.40137413
123PRKCQ0.40080405
124CAMK1D0.39895826
125SGK10.39393826
126RET0.38909926
127MAP3K60.38488186
128RPS6KB10.37032537
129FLT30.37002583
130EIF2AK10.36933493
131PRPF4B0.36716507
132CDK150.36247655
133PRKCB0.35554577
134LATS10.34580318
135RIPK10.34548811
136CCNB10.33903274
137PRKCA0.33676082
138STK110.33294844
139PRKG10.33198549
140GRK50.33091763
141GRK60.32995163
142OXSR10.32520194
143CDK180.32303128
144CDK30.32026722
145ERN10.32023821
146CDC42BPA0.31771984
147PRKACA0.31672676
148CDK120.31246432
149CDK190.30854180
150RPS6KA30.30469551
151MAPK100.29782743
152PRKCE0.29316960
153CDK11A0.27267987

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.50827746
2Fatty acid biosynthesis_Homo sapiens_hsa000614.11618179
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.88584065
4Caffeine metabolism_Homo sapiens_hsa002322.82424224
5Retinol metabolism_Homo sapiens_hsa008302.60960485
6Histidine metabolism_Homo sapiens_hsa003402.16275394
7Fatty acid metabolism_Homo sapiens_hsa012122.11384668
8Tyrosine metabolism_Homo sapiens_hsa003502.10026470
9Phenylalanine metabolism_Homo sapiens_hsa003602.05477258
10Nicotine addiction_Homo sapiens_hsa050332.01191866
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.01164383
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.98975993
13ECM-receptor interaction_Homo sapiens_hsa045121.94272761
14Bile secretion_Homo sapiens_hsa049761.92097705
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.72052013
16Steroid biosynthesis_Homo sapiens_hsa001001.71198205
17PPAR signaling pathway_Homo sapiens_hsa033201.69082838
18Fatty acid degradation_Homo sapiens_hsa000711.68140448
19Drug metabolism - other enzymes_Homo sapiens_hsa009831.67151271
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65360642
21Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.54384504
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53354819
23Propanoate metabolism_Homo sapiens_hsa006401.50772781
24Pyruvate metabolism_Homo sapiens_hsa006201.50716402
25Vitamin B6 metabolism_Homo sapiens_hsa007501.48745800
26GABAergic synapse_Homo sapiens_hsa047271.47837326
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.47326645
28Glutamatergic synapse_Homo sapiens_hsa047241.47324392
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.46379258
30Staphylococcus aureus infection_Homo sapiens_hsa051501.45023655
31Protein digestion and absorption_Homo sapiens_hsa049741.41404100
32Salivary secretion_Homo sapiens_hsa049701.40887691
33Fructose and mannose metabolism_Homo sapiens_hsa000511.36138768
34Arginine biosynthesis_Homo sapiens_hsa002201.34311500
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.34265397
36Dorso-ventral axis formation_Homo sapiens_hsa043201.32699618
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.29232056
38ABC transporters_Homo sapiens_hsa020101.28519378
39Insulin secretion_Homo sapiens_hsa049111.28439346
40Amphetamine addiction_Homo sapiens_hsa050311.24933392
41Glucagon signaling pathway_Homo sapiens_hsa049221.21006453
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.17611182
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.16952740
44Glycerophospholipid metabolism_Homo sapiens_hsa005641.16013812
45One carbon pool by folate_Homo sapiens_hsa006701.15428166
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13741899
47Basal cell carcinoma_Homo sapiens_hsa052171.13143969
48Circadian entrainment_Homo sapiens_hsa047131.13116438
49Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.12127805
50beta-Alanine metabolism_Homo sapiens_hsa004101.08942650
51Mineral absorption_Homo sapiens_hsa049781.08174995
52Hedgehog signaling pathway_Homo sapiens_hsa043401.04972423
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04254408
54Biosynthesis of amino acids_Homo sapiens_hsa012301.02785004
55Olfactory transduction_Homo sapiens_hsa047401.01033536
56Gastric acid secretion_Homo sapiens_hsa049711.00133414
57Complement and coagulation cascades_Homo sapiens_hsa046100.98869785
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98744749
59Long-term potentiation_Homo sapiens_hsa047200.98274523
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96481993
61Glycerolipid metabolism_Homo sapiens_hsa005610.95315306
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93776883
63Arachidonic acid metabolism_Homo sapiens_hsa005900.90613029
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90181554
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89704409
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89061057
67Selenocompound metabolism_Homo sapiens_hsa004500.88665745
68Renin secretion_Homo sapiens_hsa049240.88290362
69Calcium signaling pathway_Homo sapiens_hsa040200.87347069
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87169455
71Morphine addiction_Homo sapiens_hsa050320.87025178
72Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.84696831
73Cocaine addiction_Homo sapiens_hsa050300.83021739
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.79873311
75Pentose phosphate pathway_Homo sapiens_hsa000300.77385436
76Prion diseases_Homo sapiens_hsa050200.76470076
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76108894
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73537657
79Carbon metabolism_Homo sapiens_hsa012000.73357238
80Synaptic vesicle cycle_Homo sapiens_hsa047210.72974139
81Arginine and proline metabolism_Homo sapiens_hsa003300.72591427
82Taste transduction_Homo sapiens_hsa047420.72523232
83Thyroid hormone synthesis_Homo sapiens_hsa049180.68509217
84Vitamin digestion and absorption_Homo sapiens_hsa049770.66721023
85Sulfur metabolism_Homo sapiens_hsa009200.66218848
86cAMP signaling pathway_Homo sapiens_hsa040240.64600033
87Melanogenesis_Homo sapiens_hsa049160.63470686
88Folate biosynthesis_Homo sapiens_hsa007900.62924391
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61707613
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61608170
91Wnt signaling pathway_Homo sapiens_hsa043100.60639623
92Metabolic pathways_Homo sapiens_hsa011000.60305738
93Circadian rhythm_Homo sapiens_hsa047100.59543376
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59040268
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58777971
96Linoleic acid metabolism_Homo sapiens_hsa005910.58705020
97Ether lipid metabolism_Homo sapiens_hsa005650.58106507
98Peroxisome_Homo sapiens_hsa041460.57612086
99Sulfur relay system_Homo sapiens_hsa041220.57469177
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55758918
101Pancreatic secretion_Homo sapiens_hsa049720.55178162
102Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54966910
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52472448
104Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51622611
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49731222
106Tryptophan metabolism_Homo sapiens_hsa003800.48872080
107Cardiac muscle contraction_Homo sapiens_hsa042600.48523375
108Chemical carcinogenesis_Homo sapiens_hsa052040.48284141
109Lysine degradation_Homo sapiens_hsa003100.47891654
110Butanoate metabolism_Homo sapiens_hsa006500.46779490
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.45694466
112Long-term depression_Homo sapiens_hsa047300.45511226
113Estrogen signaling pathway_Homo sapiens_hsa049150.44735949
114Fatty acid elongation_Homo sapiens_hsa000620.43275510
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42891111
116Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42505605
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42389256
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41796869
119Starch and sucrose metabolism_Homo sapiens_hsa005000.41554375
120Focal adhesion_Homo sapiens_hsa045100.40107031
121Glycosaminoglycan degradation_Homo sapiens_hsa005310.39581470
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39222329
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37529347
124Fat digestion and absorption_Homo sapiens_hsa049750.35852393
125Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35678360
126Dopaminergic synapse_Homo sapiens_hsa047280.35044757
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.34666032
128Renin-angiotensin system_Homo sapiens_hsa046140.30404506
129Insulin resistance_Homo sapiens_hsa049310.29160158
130Phototransduction_Homo sapiens_hsa047440.24552141
131Protein export_Homo sapiens_hsa030600.22960854
132Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.21559604
133Other glycan degradation_Homo sapiens_hsa005110.19834433
134Pertussis_Homo sapiens_hsa051330.18971500
135N-Glycan biosynthesis_Homo sapiens_hsa005100.18693423
136Glutathione metabolism_Homo sapiens_hsa004800.17661786
137Sphingolipid metabolism_Homo sapiens_hsa006000.08738072
138Oxidative phosphorylation_Homo sapiens_hsa001900.05273933
139Galactose metabolism_Homo sapiens_hsa000520.05266757
140Ovarian steroidogenesis_Homo sapiens_hsa049130.03594198
141Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.01946650
142Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.01281339
143Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.01167910
144AMPK signaling pathway_Homo sapiens_hsa041520.00626408
145Serotonergic synapse_Homo sapiens_hsa04726-0.0013335

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