SLC14A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the urea transporter family. In mammalian cells, urea is the chief end product of nitrogen catabolism, and plays an important role in the urinary concentration mechanism. This protein is expressed in the inner medulla of the kidney, and mediates rapid transepithelial urea transport across the inner medullary collecting duct. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)8.36161038
2excretion (GO:0007588)8.09067279
3axonemal dynein complex assembly (GO:0070286)8.04646586
4renal absorption (GO:0070293)7.90885606
5epithelial cilium movement (GO:0003351)7.67588766
6response to mercury ion (GO:0046689)7.39205877
7cilium or flagellum-dependent cell motility (GO:0001539)6.97313141
8ventricular system development (GO:0021591)6.94928474
9collecting duct development (GO:0072044)6.56177755
10left/right axis specification (GO:0070986)6.38913898
11metanephric tubule development (GO:0072170)6.34581018
12metanephric nephron tubule development (GO:0072234)6.34581018
13GTP biosynthetic process (GO:0006183)6.08682713
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.78800324
15metanephric nephron epithelium development (GO:0072243)5.75177472
16actin filament depolymerization (GO:0030042)5.62579564
17nucleoside diphosphate phosphorylation (GO:0006165)5.50507326
18cardiovascular system development (GO:0072358)5.49007189
19UTP metabolic process (GO:0046051)5.43022364
20UTP biosynthetic process (GO:0006228)5.33116490
21metanephric epithelium development (GO:0072207)5.25297968
22tryptophan catabolic process (GO:0006569)4.90763166
23indole-containing compound catabolic process (GO:0042436)4.90763166
24indolalkylamine catabolic process (GO:0046218)4.90763166
25kynurenine metabolic process (GO:0070189)4.81685284
26behavioral response to nicotine (GO:0035095)4.73661054
27indolalkylamine metabolic process (GO:0006586)4.67165698
28response to water (GO:0009415)4.66065421
29nephron tubule development (GO:0072080)4.49167336
30L-fucose catabolic process (GO:0042355)4.44664210
31fucose catabolic process (GO:0019317)4.44664210
32L-fucose metabolic process (GO:0042354)4.44664210
33cell volume homeostasis (GO:0006884)4.25179479
34guanosine-containing compound biosynthetic process (GO:1901070)4.24771325
35renal tubule development (GO:0061326)4.14709864
36intraciliary transport (GO:0042073)4.14163860
37tryptophan metabolic process (GO:0006568)4.13676457
38detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.05789169
39water transport (GO:0006833)4.05488125
40CTP metabolic process (GO:0046036)4.00093768
41CTP biosynthetic process (GO:0006241)4.00093768
42microtubule bundle formation (GO:0001578)3.89258276
43response to pheromone (GO:0019236)3.84508649
44detection of light stimulus involved in visual perception (GO:0050908)3.82686265
45detection of light stimulus involved in sensory perception (GO:0050962)3.82686265
46cilium organization (GO:0044782)3.78098026
47pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.76922124
48piRNA metabolic process (GO:0034587)3.74154319
49aspartate family amino acid catabolic process (GO:0009068)3.60982563
50lysine catabolic process (GO:0006554)3.59730408
51lysine metabolic process (GO:0006553)3.59730408
52pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.58584468
53indole-containing compound metabolic process (GO:0042430)3.58522364
54nephron epithelium development (GO:0072009)3.56213112
55fluid transport (GO:0042044)3.56127380
56urate metabolic process (GO:0046415)3.54996357
57motile cilium assembly (GO:0044458)3.50751006
58carnitine metabolic process (GO:0009437)3.50197318
59cilium assembly (GO:0042384)3.49900541
60aminoglycoside antibiotic metabolic process (GO:0030647)3.46014806
61response to copper ion (GO:0046688)3.44990923
62auditory receptor cell stereocilium organization (GO:0060088)3.44073371
63nephron tubule formation (GO:0072079)3.41588712
64cilium morphogenesis (GO:0060271)3.40265742
65behavioral response to ethanol (GO:0048149)3.37181833
66gamma-aminobutyric acid transport (GO:0015812)3.34017176
67cellular biogenic amine catabolic process (GO:0042402)3.30771092
68amine catabolic process (GO:0009310)3.30771092
69photoreceptor cell maintenance (GO:0045494)3.29559296
70signal peptide processing (GO:0006465)3.29118018
71protein K11-linked deubiquitination (GO:0035871)3.22412130
72neural tube formation (GO:0001841)3.20034365
73organic cation transport (GO:0015695)3.19993306
74reflex (GO:0060004)3.15891971
75sex differentiation (GO:0007548)3.15803143
76regulation of action potential (GO:0098900)3.15014400
77drug transmembrane transport (GO:0006855)3.14994263
78renal system process (GO:0003014)3.13820107
79regulation of glucose import in response to insulin stimulus (GO:2001273)3.12829455
80DNA methylation involved in gamete generation (GO:0043046)3.11650365
81brain morphogenesis (GO:0048854)3.10252644
82hyperosmotic response (GO:0006972)3.08111809
83phosphate ion transport (GO:0006817)3.05431370
84protein polyglutamylation (GO:0018095)3.04352247
85amino-acid betaine metabolic process (GO:0006577)3.03175388
86sulfation (GO:0051923)3.01533890
87regulation of mesenchymal cell apoptotic process (GO:2001053)3.01124947
88NAD biosynthetic process (GO:0009435)3.00413955
89nucleotide phosphorylation (GO:0046939)3.00410609
90membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.95855907
91regulation of memory T cell differentiation (GO:0043380)2.95236975
92retinal cone cell development (GO:0046549)2.94830578
93DNA deamination (GO:0045006)2.94322315
94ketone body metabolic process (GO:1902224)2.94150969
95inner ear receptor stereocilium organization (GO:0060122)2.93842169
96nucleoside diphosphate metabolic process (GO:0009132)2.93273341
97regulation of cilium movement (GO:0003352)2.92610658
98aromatic amino acid family catabolic process (GO:0009074)2.90366701
99oxidative demethylation (GO:0070989)2.89004516
100cornea development in camera-type eye (GO:0061303)2.88786290
101water-soluble vitamin biosynthetic process (GO:0042364)2.88743592
102tricarboxylic acid metabolic process (GO:0072350)2.87643385
103protein localization to cilium (GO:0061512)2.87335361
104nonmotile primary cilium assembly (GO:0035058)2.86019725
105G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.84372417
106regulation of hippo signaling (GO:0035330)2.83485993
107tachykinin receptor signaling pathway (GO:0007217)2.81973962
108pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.80929410
109benzene-containing compound metabolic process (GO:0042537)2.80671562
110neuronal action potential propagation (GO:0019227)2.80278738
111cellular component assembly involved in morphogenesis (GO:0010927)2.79039283
112neuronal action potential (GO:0019228)2.78487140
113nephron tubule morphogenesis (GO:0072078)2.77953991
114nephron epithelium morphogenesis (GO:0072088)2.77953991
115sensory perception of smell (GO:0007608)2.76200793
116purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.75870297
117preassembly of GPI anchor in ER membrane (GO:0016254)2.75517548
118serotonin metabolic process (GO:0042428)2.75500056
119glyoxylate metabolic process (GO:0046487)2.75475298
120platelet dense granule organization (GO:0060155)2.74808562
121response to salt stress (GO:0009651)2.73284997
122primary amino compound metabolic process (GO:1901160)2.73202161
123negative regulation of cytosolic calcium ion concentration (GO:0051481)2.73191257
124kidney morphogenesis (GO:0060993)2.73186597
125L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.73072142
126pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.72788448
127establishment of protein localization to Golgi (GO:0072600)2.71705263
128cAMP catabolic process (GO:0006198)2.71686500
129detection of mechanical stimulus involved in sensory perception (GO:0050974)2.70640194
130* one-carbon compound transport (GO:0019755)2.70592429
131calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.69646544
132multicellular organism reproduction (GO:0032504)2.69300889
133cellular ketone body metabolic process (GO:0046950)2.69241359
134hyperosmotic salinity response (GO:0042538)2.68892481
135mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.68762584
136purine nucleoside triphosphate biosynthetic process (GO:0009145)2.67516688
137positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.67125727
138regulation of posttranscriptional gene silencing (GO:0060147)2.65937903
139regulation of gene silencing by miRNA (GO:0060964)2.65937903
140regulation of gene silencing by RNA (GO:0060966)2.65937903
141cysteine metabolic process (GO:0006534)2.65913355
142sphingoid metabolic process (GO:0046519)2.65289871
143quaternary ammonium group transport (GO:0015697)2.64263598
144microtubule-based movement (GO:0007018)2.64121578
145tricarboxylic acid cycle (GO:0006099)2.63491581
146negative regulation of systemic arterial blood pressure (GO:0003085)2.63411112
147homocysteine metabolic process (GO:0050667)2.63228080
148acrosome assembly (GO:0001675)2.62805592
149inositol metabolic process (GO:0006020)2.61590124
150membrane repolarization during action potential (GO:0086011)2.60740924
151branched-chain amino acid metabolic process (GO:0009081)2.60467874
152negative regulation of mast cell activation (GO:0033004)2.60141649
153respiratory chain complex IV assembly (GO:0008535)2.59466962
154drug transport (GO:0015893)2.58609070
155short-chain fatty acid metabolic process (GO:0046459)2.58518031
156pyrimidine nucleobase catabolic process (GO:0006208)2.57682181
157negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.57115396
158L-methionine salvage (GO:0071267)2.55810675
159L-methionine biosynthetic process (GO:0071265)2.55810675
160amino acid salvage (GO:0043102)2.55810675
161fatty acid beta-oxidation (GO:0006635)2.54848820
162negative regulation of telomere maintenance (GO:0032205)2.52992743
163adaptation of signaling pathway (GO:0023058)2.52607222
164cyclic nucleotide catabolic process (GO:0009214)2.52437241
165transmission of nerve impulse (GO:0019226)2.52285990
166nucleobase catabolic process (GO:0046113)2.52260303
167cell projection assembly (GO:0030031)2.52247592
168positive regulation of cellular response to insulin stimulus (GO:1900078)2.51865400
169drug catabolic process (GO:0042737)2.51030767
170positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.50693773
171DNA demethylation (GO:0080111)2.49618831
172adult feeding behavior (GO:0008343)2.49203267
173negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.48619551
174negative regulation of translation, ncRNA-mediated (GO:0040033)2.48619551
175regulation of translation, ncRNA-mediated (GO:0045974)2.48619551
176membrane depolarization during action potential (GO:0086010)2.48134865
177thyroid hormone metabolic process (GO:0042403)2.47784261
178aromatic amino acid family metabolic process (GO:0009072)2.46016902
179branched-chain amino acid catabolic process (GO:0009083)2.44341118
180positive regulation of sodium ion transmembrane transport (GO:1902307)2.42951690
181inorganic anion transport (GO:0015698)2.42592930
182limb development (GO:0060173)2.42306057
183cellular potassium ion homeostasis (GO:0030007)2.38593680
184regulation of microtubule-based movement (GO:0060632)2.37968251
185sodium ion transport (GO:0006814)2.36343926
186renal tubule morphogenesis (GO:0061333)2.36115528
187ribonucleoside triphosphate biosynthetic process (GO:0009201)2.34122065
188polyol transport (GO:0015791)10.5376242
189cilium movement (GO:0003341)10.3197930

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse3.79466670
2ZNF274_21170338_ChIP-Seq_K562_Hela3.61931222
3IGF1R_20145208_ChIP-Seq_DFB_Human2.67238333
4* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.64739798
5AR_21572438_ChIP-Seq_LNCaP_Human2.51268712
6EZH2_22144423_ChIP-Seq_EOC_Human2.46331254
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.45554578
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.23979886
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.19546267
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.04175107
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.00772233
12ER_23166858_ChIP-Seq_MCF-7_Human1.97524245
13PIAS1_25552417_ChIP-Seq_VCAP_Human1.97059012
14FUS_26573619_Chip-Seq_HEK293_Human1.96277941
15EWS_26573619_Chip-Seq_HEK293_Human1.91092069
16* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.86335801
17CDX2_19796622_ChIP-Seq_MESCs_Mouse1.82206939
18SALL1_21062744_ChIP-ChIP_HESCs_Human1.81372165
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81042172
20STAT3_23295773_ChIP-Seq_U87_Human1.75931932
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.69317523
22SUZ12_27294783_Chip-Seq_ESCs_Mouse1.69136583
23UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.68751114
24RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68509000
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.66784944
26TCF4_23295773_ChIP-Seq_U87_Human1.62024475
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.57988730
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.54498837
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53794807
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.53772685
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.53408058
32GBX2_23144817_ChIP-Seq_PC3_Human1.51369970
33RNF2_18974828_ChIP-Seq_MESCs_Mouse1.51216978
34EZH2_18974828_ChIP-Seq_MESCs_Mouse1.51216978
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50032355
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.49793285
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.49733499
38AR_25329375_ChIP-Seq_VCAP_Human1.48936746
39TAF15_26573619_Chip-Seq_HEK293_Human1.48460518
40IRF1_19129219_ChIP-ChIP_H3396_Human1.47976192
41SMAD4_21799915_ChIP-Seq_A2780_Human1.47755428
42POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.47662631
43TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47662631
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.47040928
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.45929917
46SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.45812114
47NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45260760
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.44442997
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44194047
50VDR_22108803_ChIP-Seq_LS180_Human1.43364283
51PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.43239462
52ESR1_21235772_ChIP-Seq_MCF-7_Human1.42636451
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42382997
54RXR_22108803_ChIP-Seq_LS180_Human1.42077938
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.41677389
56BCAT_22108803_ChIP-Seq_LS180_Human1.40926108
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38856711
58TP53_22573176_ChIP-Seq_HFKS_Human1.38523007
59ARNT_22903824_ChIP-Seq_MCF-7_Human1.38499796
60RNF2_27304074_Chip-Seq_NSC_Mouse1.38420191
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38099157
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.37144003
63ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.37029629
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37000943
65EP300_21415370_ChIP-Seq_HL-1_Mouse1.35781598
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.35688007
67MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35274762
68AHR_22903824_ChIP-Seq_MCF-7_Human1.35233730
69SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.33352872
70CLOCK_20551151_ChIP-Seq_293T_Human1.32531555
71REST_21632747_ChIP-Seq_MESCs_Mouse1.31324726
72NANOG_19829295_ChIP-Seq_ESCs_Human1.30662963
73SOX2_19829295_ChIP-Seq_ESCs_Human1.30662963
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30356548
75PRDM14_20953172_ChIP-Seq_ESCs_Human1.30100212
76EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.29920102
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.29847715
78DROSHA_22980978_ChIP-Seq_HELA_Human1.29753809
79* RUNX2_22187159_ChIP-Seq_PCA_Human1.29302244
80WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29020930
81* P300_19829295_ChIP-Seq_ESCs_Human1.27893791
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27851507
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.25838850
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25601019
85LXR_22158963_ChIP-Seq_LIVER_Mouse1.24930907
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24777079
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.24680392
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23705991
89CBX2_27304074_Chip-Seq_ESCs_Mouse1.23671563
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23556436
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23524168
92FLI1_21867929_ChIP-Seq_TH2_Mouse1.21772421
93HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20855720
94CRX_20693478_ChIP-Seq_RETINA_Mouse1.20484512
95FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20210497
96FOXA1_25329375_ChIP-Seq_VCAP_Human1.20210497
97P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19809619
98NOTCH1_21737748_ChIP-Seq_TLL_Human1.19198463
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19103670
100RING1B_27294783_Chip-Seq_ESCs_Mouse1.18684501
101RNF2_27304074_Chip-Seq_ESCs_Mouse1.16437357
102* SMAD4_21741376_ChIP-Seq_HESCs_Human1.14272899
103TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14111241
104TCF4_22108803_ChIP-Seq_LS180_Human1.14031293
105FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13669851
106PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11713262
107P53_22387025_ChIP-Seq_ESCs_Mouse1.11066583
108NCOR_22424771_ChIP-Seq_293T_Human1.10869428
109PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10794481
110CDX2_22108803_ChIP-Seq_LS180_Human1.09497687
111GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08858447
112GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08349795
113GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08076168
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07968845
115TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05418719
116AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04177531
117KDM2B_26808549_Chip-Seq_REH_Human1.03986627
118E2F1_18555785_Chip-Seq_ESCs_Mouse1.03837382
119STAT3_18555785_Chip-Seq_ESCs_Mouse1.03794126
120OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03661428
121ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03027329
122SMAD3_21741376_ChIP-Seq_EPCs_Human1.02647031
123TP53_16413492_ChIP-PET_HCT116_Human1.00259790
124* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99672483
125* SOX2_21211035_ChIP-Seq_LN229_Gbm0.99288074
126* AR_20517297_ChIP-Seq_VCAP_Human0.99273903
127SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99271770
128SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98743136
129P300_18555785_Chip-Seq_ESCs_Mouse0.98688798
130CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98312521
131GATA3_21878914_ChIP-Seq_MCF-7_Human0.98098346
132RING1B_27294783_Chip-Seq_NPCs_Mouse0.97294647
133BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.96296183
134* SMAD3_21741376_ChIP-Seq_HESCs_Human0.94942563
135RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93802187
136* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93463313
137STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91969556
138RXR_22158963_ChIP-Seq_LIVER_Mouse0.91883769
139* CJUN_26792858_Chip-Seq_BT549_Human0.90599997
140FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89963696
141* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89757000
142BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89535465
143PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88486978
144IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87896786
145CBP_20019798_ChIP-Seq_JUKART_Human0.87896786
146SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87427324
147FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.86322092
148PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.85715948
149FOXH1_21741376_ChIP-Seq_ESCs_Human0.85408248
150EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85311182
151SOX2_22085726_ChIP-Seq_NPCs_Mouse0.85187539
152TP53_20018659_ChIP-ChIP_R1E_Mouse0.83766867
153SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.82343823
154* LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.82152286
155ESR2_21235772_ChIP-Seq_MCF-7_Human0.81336270
156GATA4_25053715_ChIP-Seq_YYC3_Human0.81008978
157TBL1_22424771_ChIP-Seq_293T_Human0.80955428
158SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.80796084
159* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80529783
160SMAD3_21741376_ChIP-Seq_ESCs_Human0.80103159
161NANOG_18555785_Chip-Seq_ESCs_Mouse0.80095580
162EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.79482481
163PHF8_20622853_ChIP-Seq_HELA_Human0.79409948
164ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.78797865

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation9.01725698
2MP0003195_calcinosis7.40950117
3* MP0001756_abnormal_urination4.73844500
4MP0000569_abnormal_digit_pigmentation3.65286134
5MP0001765_abnormal_ion_homeostasis3.19053705
6* MP0009643_abnormal_urine_homeostasis2.91928885
7MP0008004_abnormal_stomach_pH2.89051294
8MP0005332_abnormal_amino_acid2.71309931
9MP0005551_abnormal_eye_electrophysiolog2.62669040
10MP0008877_abnormal_DNA_methylation2.60580524
11MP0004885_abnormal_endolymph2.59378375
12MP0003283_abnormal_digestive_organ2.50944974
13MP0001968_abnormal_touch/_nociception2.49849465
14MP0005636_abnormal_mineral_homeostasis2.44079557
15MP0002653_abnormal_ependyma_morphology2.43241126
16MP0002102_abnormal_ear_morphology2.38369742
17MP0001984_abnormal_olfaction2.36411805
18MP0009046_muscle_twitch2.20525391
19MP0005623_abnormal_meninges_morphology2.18531248
20* MP0002136_abnormal_kidney_physiology2.17267208
21MP0005360_urolithiasis2.07559193
22MP0002837_dystrophic_cardiac_calcinosis2.05211352
23MP0000538_abnormal_urinary_bladder2.03166131
24MP0009745_abnormal_behavioral_response1.97347834
25MP0002928_abnormal_bile_duct1.93912228
26MP0003136_yellow_coat_color1.90537273
27MP0005253_abnormal_eye_physiology1.88084648
28MP0001986_abnormal_taste_sensitivity1.86041332
29MP0002234_abnormal_pharynx_morphology1.82771190
30MP0008961_abnormal_basal_metabolism1.78354465
31MP0002138_abnormal_hepatobiliary_system1.77757529
32MP0004147_increased_porphyrin_level1.77393883
33MP0004019_abnormal_vitamin_homeostasis1.75340524
34MP0000534_abnormal_ureter_morphology1.74688558
35MP0000427_abnormal_hair_cycle1.70233297
36MP0002272_abnormal_nervous_system1.68584870
37MP0001270_distended_abdomen1.67522572
38MP0003252_abnormal_bile_duct1.63560524
39MP0001486_abnormal_startle_reflex1.62549109
40MP0002168_other_aberrant_phenotype1.62172691
41MP0008789_abnormal_olfactory_epithelium1.59237852
42MP0006072_abnormal_retinal_apoptosis1.59191905
43MP0004142_abnormal_muscle_tone1.57034218
44MP0003787_abnormal_imprinting1.56999900
45MP0005646_abnormal_pituitary_gland1.53087904
46MP0004133_heterotaxia1.51131211
47MP0004742_abnormal_vestibular_system1.44075242
48MP0003011_delayed_dark_adaptation1.41264969
49MP0002064_seizures1.36100538
50MP0005174_abnormal_tail_pigmentation1.36095700
51MP0002572_abnormal_emotion/affect_behav1.34689211
52MP0002139_abnormal_hepatobiliary_system1.32427446
53MP0005499_abnormal_olfactory_system1.31221472
54MP0005394_taste/olfaction_phenotype1.31221472
55MP0001970_abnormal_pain_threshold1.30494961
56MP0003718_maternal_effect1.30054579
57MP0003880_abnormal_central_pattern1.29403769
58MP0000372_irregular_coat_pigmentation1.28050607
59MP0000383_abnormal_hair_follicle1.24644393
60MP0004924_abnormal_behavior1.24565535
61MP0005386_behavior/neurological_phenoty1.24565535
62MP0002638_abnormal_pupillary_reflex1.23842909
63MP0002733_abnormal_thermal_nociception1.23598905
64MP0003959_abnormal_lean_body1.19931501
65MP0001440_abnormal_grooming_behavior1.18174437
66MP0006292_abnormal_olfactory_placode1.17369454
67MP0004858_abnormal_nervous_system1.14647464
68MP0010234_abnormal_vibrissa_follicle1.12774564
69MP0003942_abnormal_urinary_system1.11379488
70MP0005410_abnormal_fertilization1.09477269
71MP0005075_abnormal_melanosome_morpholog1.09279616
72MP0001529_abnormal_vocalization1.07905674
73MP0003635_abnormal_synaptic_transmissio1.07611489
74MP0001485_abnormal_pinna_reflex1.07271952
75MP0000230_abnormal_systemic_arterial1.03248473
76MP0001944_abnormal_pancreas_morphology1.02876151
77MP0004215_abnormal_myocardial_fiber1.02180152
78MP0002938_white_spotting1.01930914
79MP0010329_abnormal_lipoprotein_level1.01585109
80MP0005220_abnormal_exocrine_pancreas1.00758146
81MP0004145_abnormal_muscle_electrophysio0.99990291
82MP0002063_abnormal_learning/memory/cond0.98663406
83MP0005167_abnormal_blood-brain_barrier0.97923588
84MP0005535_abnormal_body_temperature0.97407041
85MP0003119_abnormal_digestive_system0.96513240
86MP0010386_abnormal_urinary_bladder0.95883282
87MP0000778_abnormal_nervous_system0.94787793
88MP0002736_abnormal_nociception_after0.90111504
89MP0002229_neurodegeneration0.90077954
90MP0003698_abnormal_male_reproductive0.90066986
91MP0005195_abnormal_posterior_eye0.89923312
92MP0002233_abnormal_nose_morphology0.89871032
93MP0003950_abnormal_plasma_membrane0.89752001
94MP0002095_abnormal_skin_pigmentation0.89644587
95MP0005423_abnormal_somatic_nervous0.89089581
96MP0002693_abnormal_pancreas_physiology0.88333612
97MP0002135_abnormal_kidney_morphology0.87373334
98MP0002160_abnormal_reproductive_system0.85971660
99MP0003878_abnormal_ear_physiology0.85087501
100MP0005377_hearing/vestibular/ear_phenot0.85087501
101MP0002069_abnormal_eating/drinking_beha0.84967039
102MP0002752_abnormal_somatic_nervous0.83109588
103MP0003137_abnormal_impulse_conducting0.82059080
104MP0002876_abnormal_thyroid_physiology0.81479965
105MP0005647_abnormal_sex_gland0.80285116
106MP0000631_abnormal_neuroendocrine_gland0.80027848
107MP0002896_abnormal_bone_mineralization0.78780950
108MP0000013_abnormal_adipose_tissue0.77923807
109MP0003300_gastrointestinal_ulcer0.77913068
110MP0008057_abnormal_DNA_replication0.77756481
111MP0005365_abnormal_bile_salt0.77059421
112MP0002282_abnormal_trachea_morphology0.76553980
113MP0001958_emphysema0.76291552
114MP0005448_abnormal_energy_balance0.74897698
115MP0001177_atelectasis0.74878337
116MP0009780_abnormal_chondrocyte_physiolo0.74870360
117MP0005379_endocrine/exocrine_gland_phen0.73848531
118MP0002078_abnormal_glucose_homeostasis0.73449492
119MP0003121_genomic_imprinting0.72564325
120MP0005395_other_phenotype0.70421929
121MP0000015_abnormal_ear_pigmentation0.70115559
122MP0005085_abnormal_gallbladder_physiolo0.67096110
123MP0008872_abnormal_physiological_respon0.65604785
124MP0003634_abnormal_glial_cell0.64459293
125MP0002557_abnormal_social/conspecific_i0.64207665
126MP0005584_abnormal_enzyme/coenzyme_acti0.63499498
127MP0000026_abnormal_inner_ear0.62199376
128MP0002735_abnormal_chemical_nociception0.59180327
129MP0000462_abnormal_digestive_system0.58964884
130MP0005389_reproductive_system_phenotype0.58398000
131MP0000762_abnormal_tongue_morphology0.56711645
132MP0002092_abnormal_eye_morphology0.55815805
133MP0001963_abnormal_hearing_physiology0.55524243
134MP0006276_abnormal_autonomic_nervous0.54817305
135MP0003953_abnormal_hormone_level0.54379950
136MP0005388_respiratory_system_phenotype0.53941506
137MP0002133_abnormal_respiratory_system0.53941506
138MP0001502_abnormal_circadian_rhythm0.52791844
139MP0001293_anophthalmia0.51762213
140MP0006036_abnormal_mitochondrial_physio0.51435856
141MP0001501_abnormal_sleep_pattern0.50745523
142MP0005319_abnormal_enzyme/_coenzyme0.50491129
143MP0003186_abnormal_redox_activity0.50286690
144MP0003938_abnormal_ear_development0.50059839
145MP0003879_abnormal_hair_cell0.49657710
146MP0005645_abnormal_hypothalamus_physiol0.49287516
147MP0000049_abnormal_middle_ear0.49139464
148MP0002734_abnormal_mechanical_nocicepti0.48144761
149MP0003646_muscle_fatigue0.47540240
150MP0001664_abnormal_digestion0.47097763
151MP0002249_abnormal_larynx_morphology0.45844187
152MP0005084_abnormal_gallbladder_morpholo0.45679844
153MP0008875_abnormal_xenobiotic_pharmacok0.45321919
154MP0002909_abnormal_adrenal_gland0.44437995
155MP0002067_abnormal_sensory_capabilities0.43982100
156MP0001764_abnormal_homeostasis0.41840269
157MP0003329_amyloid_beta_deposits0.41570256

Predicted human phenotypes

RankGene SetZ-score
1Hypokalemic alkalosis (HP:0001949)9.38200563
2Polyuria (HP:0000103)8.47770438
3Abnormality of chloride homeostasis (HP:0011422)8.14346372
4Abnormal urine output (HP:0012590)7.76899224
5Hyperactive renin-angiotensin system (HP:0000841)7.51043189
6Increased circulating renin level (HP:0000848)7.47459366
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.34963213
8Polydipsia (HP:0001959)7.21814330
9Abnormal drinking behavior (HP:0030082)7.21814330
10Hyperaldosteronism (HP:0000859)6.94120625
11Hypomagnesemia (HP:0002917)6.83718713
12Renal salt wasting (HP:0000127)6.76428562
13Abnormality of renal excretion (HP:0011036)6.75383459
14Abnormal respiratory motile cilium physiology (HP:0012261)6.13417027
15Abnormality of magnesium homeostasis (HP:0004921)5.70616795
16Alkalosis (HP:0001948)5.46257658
17Rhinitis (HP:0012384)5.29047842
18Abnormal ciliary motility (HP:0012262)5.26389196
19Tetany (HP:0001281)5.25924235
20Abnormality of renin-angiotensin system (HP:0000847)4.96863189
21Chronic bronchitis (HP:0004469)4.84984772
22Hypokalemia (HP:0002900)4.76157828
23Abnormal respiratory motile cilium morphology (HP:0005938)4.11743551
24Abnormal respiratory epithelium morphology (HP:0012253)4.11743551
25Congenital stationary night blindness (HP:0007642)4.11143440
26Hyperventilation (HP:0002883)4.05950682
27Abnormality of sodium homeostasis (HP:0010931)3.95372218
28Genetic anticipation (HP:0003743)3.82156430
29Abnormality of potassium homeostasis (HP:0011042)3.75421961
30Gaze-evoked nystagmus (HP:0000640)3.61367777
31Gout (HP:0001997)3.51143063
32Tubular atrophy (HP:0000092)3.49407774
33Dynein arm defect of respiratory motile cilia (HP:0012255)3.42402677
34Absent/shortened dynein arms (HP:0200106)3.42402677
35Attenuation of retinal blood vessels (HP:0007843)3.41106552
36Progressive cerebellar ataxia (HP:0002073)3.40638114
37Adrenal overactivity (HP:0002717)3.40057900
38Type II lissencephaly (HP:0007260)3.32573617
39Hyponatremia (HP:0002902)3.10829877
40Abolished electroretinogram (ERG) (HP:0000550)3.07019119
41Pendular nystagmus (HP:0012043)2.97845697
42Keratoconus (HP:0000563)2.85122128
43Increased corneal curvature (HP:0100692)2.85122128
44Hypercalciuria (HP:0002150)2.84006831
45Renal cortical cysts (HP:0000803)2.78410468
46Clumsiness (HP:0002312)2.73989571
47Bronchiectasis (HP:0002110)2.72547724
48Inability to walk (HP:0002540)2.71685039
49Abnormality of fatty-acid metabolism (HP:0004359)2.69960751
50Tubulointerstitial fibrosis (HP:0005576)2.63950571
51Abnormal rod and cone electroretinograms (HP:0008323)2.61482655
52Protruding tongue (HP:0010808)2.60619814
53Progressive inability to walk (HP:0002505)2.60037990
54Tubulointerstitial abnormality (HP:0001969)2.57532749
55Abnormality of the renal medulla (HP:0100957)2.57285852
56Pancreatic fibrosis (HP:0100732)2.56813829
57Cerebellar dysplasia (HP:0007033)2.55839031
58Broad-based gait (HP:0002136)2.55217632
59Aplasia/Hypoplasia of the tibia (HP:0005772)2.55130599
60Abnormality of the renal cortex (HP:0011035)2.54877022
61Decreased central vision (HP:0007663)2.49666958
62Lissencephaly (HP:0001339)2.48744684
63Hyperalaninemia (HP:0003348)2.46684046
64Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.46684046
65Abnormality of alanine metabolism (HP:0010916)2.46684046
66Fair hair (HP:0002286)2.43840159
67Decreased electroretinogram (ERG) amplitude (HP:0000654)2.43139622
68Abnormality of macular pigmentation (HP:0008002)2.42674535
69Chorioretinal atrophy (HP:0000533)2.41577327
70Decreased circulating renin level (HP:0003351)2.35950914
71Nephrogenic diabetes insipidus (HP:0009806)2.34454721
72Congenital primary aphakia (HP:0007707)2.33977069
73Absent rod-and cone-mediated responses on ERG (HP:0007688)2.31779943
74True hermaphroditism (HP:0010459)2.31150635
75Absent speech (HP:0001344)2.30718637
76Increased purine levels (HP:0004368)2.30495207
77Hyperuricemia (HP:0002149)2.30495207
78Large for gestational age (HP:0001520)2.24878734
79Febrile seizures (HP:0002373)2.22278454
80Tubulointerstitial nephritis (HP:0001970)2.21037581
81Sclerocornea (HP:0000647)2.20961747
82Severe visual impairment (HP:0001141)2.18216231
83Bony spicule pigmentary retinopathy (HP:0007737)2.16570236
84Dehydration (HP:0001944)2.15336268
85Congenital sensorineural hearing impairment (HP:0008527)2.11504311
86Cystic liver disease (HP:0006706)2.10699073
87Pancreatic cysts (HP:0001737)2.07067363
88Birth length less than 3rd percentile (HP:0003561)2.05672758
89Genital tract atresia (HP:0001827)2.04900738
90Nephrocalcinosis (HP:0000121)2.04883530
91Patellar aplasia (HP:0006443)2.04788018
92Focal seizures (HP:0007359)2.02643450
93Large eyes (HP:0001090)2.01002396
94Metabolic alkalosis (HP:0200114)10.6477707
95Anencephaly (HP:0002323)1.99228213
96Furrowed tongue (HP:0000221)1.98444065
97Hypothermia (HP:0002045)1.97786248
98Aplasia/Hypoplasia of the patella (HP:0006498)1.96344701
99Aplasia/Hypoplasia of the fovea (HP:0008060)1.96273321
100Hypoplasia of the fovea (HP:0007750)1.96273321
101Retinal dysplasia (HP:0007973)1.94995653
102Vaginal atresia (HP:0000148)1.91949866
103Bronchitis (HP:0012387)1.91084515
104Hemiparesis (HP:0001269)1.90897699
105Dialeptic seizures (HP:0011146)1.90587317
106Widely spaced teeth (HP:0000687)1.88505622
107Stomach cancer (HP:0012126)1.88060221
108Abnormality of the pons (HP:0007361)1.87741772
109Bile duct proliferation (HP:0001408)1.85586132
110Abnormal biliary tract physiology (HP:0012439)1.85586132
111Ketoacidosis (HP:0001993)1.85020473
112Male pseudohermaphroditism (HP:0000037)1.84929909
113Retinitis pigmentosa (HP:0000510)1.84537235
114Generalized hypopigmentation of hair (HP:0011358)1.83444040
115Abnormality of purine metabolism (HP:0004352)1.83014639
116Stage 5 chronic kidney disease (HP:0003774)1.82477466
117Hyperglycinuria (HP:0003108)1.81511779
118Neonatal onset (HP:0003623)1.80283530
119Hypoplasia of the pons (HP:0012110)1.79629804
120Focal motor seizures (HP:0011153)1.78980196
121Chondrocalcinosis (HP:0000934)1.78700284
122Central scotoma (HP:0000603)1.77731113
123Pachygyria (HP:0001302)1.77294500
124Nephronophthisis (HP:0000090)1.77232035
125Severe muscular hypotonia (HP:0006829)1.76908350
126Intestinal atresia (HP:0011100)1.76734070
127Optic nerve hypoplasia (HP:0000609)1.76555491
128Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.75242432
129Hypotension (HP:0002615)1.73295737
130Occipital encephalocele (HP:0002085)1.73140145
131Abnormality of Sharpey fibers (HP:0100685)1.72920655
132Nasal polyposis (HP:0100582)1.68267892
133Chronic hepatic failure (HP:0100626)1.66611305
134Postaxial foot polydactyly (HP:0001830)1.62438723
135Congenital hepatic fibrosis (HP:0002612)1.59639173
136Potter facies (HP:0002009)1.58838325
137Facial shape deformation (HP:0011334)1.58838325
138Proximal tubulopathy (HP:0000114)1.57430040
139Generalized muscle weakness (HP:0003324)1.54463026
140Abnormality of dentin (HP:0010299)1.53556028
141Molar tooth sign on MRI (HP:0002419)1.53000420
142Abnormality of midbrain morphology (HP:0002418)1.53000420
143Generalized aminoaciduria (HP:0002909)1.50948775
144Abnormality of serine family amino acid metabolism (HP:0010894)1.49884603
145Abnormality of glycine metabolism (HP:0010895)1.49884603
146Recurrent sinusitis (HP:0011108)1.48106431
147Neoplasm of head and neck (HP:0012288)1.44701456
148Esophageal neoplasm (HP:0100751)1.44701456
149Enlarged kidneys (HP:0000105)1.44080985
150Ketosis (HP:0001946)1.43868353
151Abnormality of the nasal mucosa (HP:0000433)1.41756870
152Vomiting (HP:0002013)1.38249068
153Chronic sinusitis (HP:0011109)1.38097698
154Renal tubular acidosis (HP:0001947)1.29643945
155Aplasia/Hypoplasia of the tongue (HP:0010295)1.27401638
156Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.27333791
157Broad distal phalanx of finger (HP:0009836)1.23563778
158Tachypnea (HP:0002789)1.20919898
159Facial cleft (HP:0002006)1.17504209
160Recurrent otitis media (HP:0000403)1.16546435
161Hyperkalemia (HP:0002153)1.15812762
162Glomerulosclerosis (HP:0000096)1.15581080
163Hyperglycinemia (HP:0002154)1.15452651
164Medial flaring of the eyebrow (HP:0010747)1.14235360
165Median cleft lip (HP:0000161)1.12516051
166Gait imbalance (HP:0002141)1.12501988

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.72331726
2OXSR16.44162249
3WNK45.04728609
4MAPK154.52417635
5ACVR1B3.41056787
6ADRBK22.83919614
7PNCK2.62359670
8NUAK12.33704829
9ZAK2.25246643
10MAP4K22.24117987
11SGK22.22931798
12SGK2232.18955463
13SGK4942.18955463
14TAOK32.02255583
15WNK311.9469404
16CASK1.80218244
17SGK31.67575351
18BCKDK1.66244172
19TLK11.54316362
20TXK1.46949200
21STK391.45239477
22WNK11.37894073
23TNIK1.25127894
24ADRBK11.23465813
25MKNK21.20535153
26SIK11.18937915
27MST41.09944299
28TRIM281.07702360
29BCR1.02304148
30TNK21.01178684
31PDK30.98544349
32PDK40.98544349
33STK38L0.95971302
34CDK190.92389579
35PIK3CA0.92066015
36STK110.90691515
37TEC0.88106794
38PIK3CG0.86483852
39PRKD30.85779130
40TRIB30.84770301
41CAMKK20.80516938
42GRK10.78601815
43EEF2K0.73577417
44IRAK10.69193778
45MAPKAPK30.67234429
46STK30.67133853
47PDK20.64315609
48PKN10.64120810
49BRSK20.64101990
50TRPM70.63297912
51DYRK20.63012299
52ITK0.61517523
53CAMK2A0.60648739
54PAK30.59628441
55MAP3K70.58445819
56CSNK1G20.56534815
57PLK20.56162420
58DAPK20.53126524
59MKNK10.52023562
60CDK80.50923069
61PTK60.50036358
62PRKAA10.49647650
63FGFR20.49626907
64MAP2K60.48777877
65IKBKB0.47634272
66RPS6KA50.47595497
67GSK3A0.46526683
68MST1R0.46067719
69CSNK1G30.46013214
70OBSCN0.43890229
71NTRK20.42831464
72SIK20.42766215
73ERBB30.42317517
74PRKD20.41146606
75SCYL20.41126847
76RPS6KA20.40773082
77NME10.40683849
78MAPK130.40529078
79PHKG20.39712549
80PHKG10.39712549
81SGK10.38912786
82PTK20.38512860
83AKT30.38026761
84FLT30.37955773
85KIT0.37871895
86CSNK1D0.37179915
87NLK0.37078526
88PRKG10.36342380
89PRKCQ0.35485869
90CAMK10.35118067
91GRK70.34964800
92EPHA40.34758632
93HIPK20.34490849
94NTRK10.34393487
95LMTK20.33746248
96TIE10.33038294
97CSNK1A10.32960937
98CAMKK10.32725101
99PAK20.32048236
100STK380.31841787
101CHUK0.31323025
102PINK10.31025444
103CDK30.30750658
104PLK40.30631290
105PRKCH0.29380061
106ABL10.29216098
107GRK50.28784499
108MINK10.28730020
109DYRK1B0.27070869
110DYRK30.26605078
111BMPR1B0.26036762
112PRKACA0.25689730
113STK100.25193944
114PRKACG0.24478564
115PRKCG0.24316263
116LATS10.23067219
117MARK10.22882311
118VRK10.21575183
119FER0.21179910
120LRRK20.21017057
121PDGFRA0.20280219
122ROCK10.20273559
123ERN10.19412314
124PRKAA20.18757696
125PTK2B0.18685493
126PRKCZ0.18537761
127MAP3K20.18535670
128EPHB10.18029895
129PRKCE0.17755700
130INSRR0.17325433
131ROCK20.16698250
132CSNK1G10.15461654
133ICK0.15366936
134CDK50.14951417
135MUSK0.14472425
136NTRK30.14350623
137MAPK110.13733607
138TGFBR10.13615995
139CAMK1G0.13423651
140MAP2K40.12621589
141PAK60.11899164
142MAP3K40.11815267
143SRC0.11162469
144MAP2K70.11098924
145PRKCA0.10860101
146PRKD10.10108818
147CSNK1A1L0.09324944
148MAPKAPK50.08480302
149CSNK1E0.08379555
150AKT20.08357806
151IRAK20.07725448
152MARK30.07536947
153RPS6KA30.07019568
154MTOR0.06980623
155KSR10.06979621
156ERBB20.06663385
157NEK10.06238100
158ERBB40.05875341

Predicted pathways (KEGG)

RankGene SetZ-score
1Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049644.27165756
2Vasopressin-regulated water reabsorption_Homo sapiens_hsa049623.45229964
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.28581686
4Propanoate metabolism_Homo sapiens_hsa006402.88139292
5Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.74572741
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.73834768
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.71731549
8Linoleic acid metabolism_Homo sapiens_hsa005912.66821468
9Butanoate metabolism_Homo sapiens_hsa006502.61113411
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.50747052
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.48289017
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.28669129
13Nicotine addiction_Homo sapiens_hsa050332.22527378
14Collecting duct acid secretion_Homo sapiens_hsa049662.21456803
15Sulfur metabolism_Homo sapiens_hsa009202.20477484
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.12865142
17Ether lipid metabolism_Homo sapiens_hsa005652.08175747
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.05771519
19Caffeine metabolism_Homo sapiens_hsa002322.03832379
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.03379098
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.02494559
22Fatty acid degradation_Homo sapiens_hsa000711.99320451
23Bile secretion_Homo sapiens_hsa049761.93092225
24Pyruvate metabolism_Homo sapiens_hsa006201.92758908
25Gastric acid secretion_Homo sapiens_hsa049711.91464536
26Nitrogen metabolism_Homo sapiens_hsa009101.91129719
27Oxidative phosphorylation_Homo sapiens_hsa001901.77236476
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.67881294
29Selenocompound metabolism_Homo sapiens_hsa004501.67551936
30Olfactory transduction_Homo sapiens_hsa047401.64108549
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.63984634
32Mineral absorption_Homo sapiens_hsa049781.50390598
33Huntingtons disease_Homo sapiens_hsa050161.49844121
34Homologous recombination_Homo sapiens_hsa034401.49790535
35Fatty acid metabolism_Homo sapiens_hsa012121.48679894
36Carbohydrate digestion and absorption_Homo sapiens_hsa049731.43979756
37Peroxisome_Homo sapiens_hsa041461.43127788
38Insulin secretion_Homo sapiens_hsa049111.42653390
39Basal transcription factors_Homo sapiens_hsa030221.35527821
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.33335846
41Thyroid hormone synthesis_Homo sapiens_hsa049181.33164245
42Retinol metabolism_Homo sapiens_hsa008301.32926235
43Tryptophan metabolism_Homo sapiens_hsa003801.32666690
44PPAR signaling pathway_Homo sapiens_hsa033201.29146503
45Fanconi anemia pathway_Homo sapiens_hsa034601.27426873
46Parkinsons disease_Homo sapiens_hsa050121.25711578
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.24475636
48Glutamatergic synapse_Homo sapiens_hsa047241.21455361
49Carbon metabolism_Homo sapiens_hsa012001.21094808
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.17901645
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15396884
52Serotonergic synapse_Homo sapiens_hsa047261.11608607
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10846036
54Arachidonic acid metabolism_Homo sapiens_hsa005901.10679677
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.10466295
56RNA polymerase_Homo sapiens_hsa030201.03336728
57Alzheimers disease_Homo sapiens_hsa050101.03017455
58Pentose and glucuronate interconversions_Homo sapiens_hsa000401.02430234
59Cardiac muscle contraction_Homo sapiens_hsa042601.01983590
60Protein digestion and absorption_Homo sapiens_hsa049740.98672737
61Vibrio cholerae infection_Homo sapiens_hsa051100.97658912
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89670841
63Calcium signaling pathway_Homo sapiens_hsa040200.87851027
64Glutathione metabolism_Homo sapiens_hsa004800.87385140
65One carbon pool by folate_Homo sapiens_hsa006700.86614610
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82742857
67Vitamin digestion and absorption_Homo sapiens_hsa049770.81493751
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.81086346
69Regulation of autophagy_Homo sapiens_hsa041400.80594582
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79781625
71Synaptic vesicle cycle_Homo sapiens_hsa047210.78848003
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78171790
73beta-Alanine metabolism_Homo sapiens_hsa004100.76866274
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76665265
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76210576
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75408142
77Fat digestion and absorption_Homo sapiens_hsa049750.74494829
78Other glycan degradation_Homo sapiens_hsa005110.73474919
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72401622
80Long-term depression_Homo sapiens_hsa047300.71481367
81Dorso-ventral axis formation_Homo sapiens_hsa043200.70232644
82Glucagon signaling pathway_Homo sapiens_hsa049220.68321637
83Fatty acid elongation_Homo sapiens_hsa000620.68276489
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67118234
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64779498
86cAMP signaling pathway_Homo sapiens_hsa040240.64152491
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.61330940
88ABC transporters_Homo sapiens_hsa020100.61139106
89GABAergic synapse_Homo sapiens_hsa047270.59167123
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57820249
91Circadian rhythm_Homo sapiens_hsa047100.57410387
92RNA degradation_Homo sapiens_hsa030180.57188909
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.56997934
94Lysine degradation_Homo sapiens_hsa003100.56293479
95Lysosome_Homo sapiens_hsa041420.55463432
96Purine metabolism_Homo sapiens_hsa002300.54160962
97Non-homologous end-joining_Homo sapiens_hsa034500.53009838
98Arginine biosynthesis_Homo sapiens_hsa002200.53003012
99Salivary secretion_Homo sapiens_hsa049700.50493647
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.50443625
101Histidine metabolism_Homo sapiens_hsa003400.50182357
102Renin secretion_Homo sapiens_hsa049240.50063887
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49793636
104Arginine and proline metabolism_Homo sapiens_hsa003300.49657727
105Glycerolipid metabolism_Homo sapiens_hsa005610.48245917
106Phenylalanine metabolism_Homo sapiens_hsa003600.47373347
107Ovarian steroidogenesis_Homo sapiens_hsa049130.45869157
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.45257992
109Pancreatic secretion_Homo sapiens_hsa049720.44085684
110Circadian entrainment_Homo sapiens_hsa047130.42512801
111Hedgehog signaling pathway_Homo sapiens_hsa043400.41971878
112Amphetamine addiction_Homo sapiens_hsa050310.41631138
113Insulin resistance_Homo sapiens_hsa049310.41543211
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39581205
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39427928
116Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38804469
117Oxytocin signaling pathway_Homo sapiens_hsa049210.38407323
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38200489
119Estrogen signaling pathway_Homo sapiens_hsa049150.37619733
120Tight junction_Homo sapiens_hsa045300.36316473
121Sphingolipid metabolism_Homo sapiens_hsa006000.35363279
122Morphine addiction_Homo sapiens_hsa050320.35183236
123Steroid hormone biosynthesis_Homo sapiens_hsa001400.34500954
124Metabolic pathways_Homo sapiens_hsa011000.34410444
125Cocaine addiction_Homo sapiens_hsa050300.34383747
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32022421
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31919896
128Fatty acid biosynthesis_Homo sapiens_hsa000610.31513258
129Protein export_Homo sapiens_hsa030600.31362741
130Type I diabetes mellitus_Homo sapiens_hsa049400.31241469
131Primary bile acid biosynthesis_Homo sapiens_hsa001200.31230588
132Chemical carcinogenesis_Homo sapiens_hsa052040.30772943
133Cholinergic synapse_Homo sapiens_hsa047250.30605148
134Drug metabolism - other enzymes_Homo sapiens_hsa009830.30574139
135Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29809005
136Asthma_Homo sapiens_hsa053100.29302545
137Hippo signaling pathway_Homo sapiens_hsa043900.29265088
138SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29227541
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29074780
140Basal cell carcinoma_Homo sapiens_hsa052170.28466427
141Starch and sucrose metabolism_Homo sapiens_hsa005000.28392035
142Melanogenesis_Homo sapiens_hsa049160.28256448
143Taste transduction_Homo sapiens_hsa047420.27437603
144Prion diseases_Homo sapiens_hsa050200.27434585
145Adipocytokine signaling pathway_Homo sapiens_hsa049200.27032173
146Dopaminergic synapse_Homo sapiens_hsa047280.26429537
147Phototransduction_Homo sapiens_hsa047440.26095730
148Biosynthesis of amino acids_Homo sapiens_hsa012300.25635106

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »