SLC15A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The mammalian kidney expresses a proton-coupled peptide transporter that is responsible for the absorption of small peptides, as well as beta-lactam antibiotics and other peptide-like drugs, from the tubular filtrate. This transporter, SLC15A2, belongs to the same gene family as SLC15A1 (MIM 600544), the proton-coupled peptide transporter found in the small intestine (Liu et al, 1995 [PubMed 7756356]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.07045947
2axonemal dynein complex assembly (GO:0070286)8.52921422
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.64829523
4cilium movement (GO:0003341)7.31111508
5epithelial cilium movement (GO:0003351)6.38410567
6axoneme assembly (GO:0035082)5.61640264
7motile cilium assembly (GO:0044458)5.37450891
8negative regulation of astrocyte differentiation (GO:0048712)5.02721471
9one-carbon compound transport (GO:0019755)4.92718890
10aminoglycoside antibiotic metabolic process (GO:0030647)4.92566152
11L-serine transport (GO:0015825)4.87242938
12L-amino acid import (GO:0043092)4.63730027
13amino acid import (GO:0043090)4.54109138
14alanine transport (GO:0032328)4.40093899
15positive regulation of cellular amide metabolic process (GO:0034250)4.39768391
16serine transport (GO:0032329)4.38515364
17regulation of cilium movement (GO:0003352)4.13964723
18surfactant homeostasis (GO:0043129)4.12922827
19renal absorption (GO:0070293)4.03112893
20presynaptic membrane assembly (GO:0097105)3.98416572
21neurotransmitter uptake (GO:0001504)3.93550645
22doxorubicin metabolic process (GO:0044598)3.88960610
23daunorubicin metabolic process (GO:0044597)3.88960610
24polyketide metabolic process (GO:0030638)3.88960610
25cilium organization (GO:0044782)3.80343227
26cilium assembly (GO:0042384)3.65567104
27mechanosensory behavior (GO:0007638)3.64927493
28neuron cell-cell adhesion (GO:0007158)3.58593405
29cellular potassium ion homeostasis (GO:0030007)3.55231848
30auditory behavior (GO:0031223)3.55206896
31regulation of phospholipid biosynthetic process (GO:0071071)3.53213379
32regulation of astrocyte differentiation (GO:0048710)3.50949416
33lateral sprouting from an epithelium (GO:0060601)3.46292005
34chemical homeostasis within a tissue (GO:0048875)3.46072774
35left/right axis specification (GO:0070986)3.44632622
36regulation of microtubule-based movement (GO:0060632)3.43050176
37presynaptic membrane organization (GO:0097090)3.41937731
38glial cell proliferation (GO:0014009)3.38834708
39intraciliary transport (GO:0042073)3.35727685
40chondroitin sulfate catabolic process (GO:0030207)3.34276019
41ovulation cycle (GO:0042698)3.18848880
42C4-dicarboxylate transport (GO:0015740)3.18175484
43metanephric tubule development (GO:0072170)3.15259628
44metanephric nephron tubule development (GO:0072234)3.15259628
45cellular response to reactive nitrogen species (GO:1902170)3.12064191
46positive regulation of chemokine secretion (GO:0090197)3.10792024
47kidney morphogenesis (GO:0060993)3.10791221
48negative regulation of cytosolic calcium ion concentration (GO:0051481)3.10559217
49lens fiber cell development (GO:0070307)3.09995939
50carnitine metabolic process (GO:0009437)3.08899011
51sodium ion export (GO:0071436)3.06848620
52organic cation transport (GO:0015695)3.04946963
53detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.02969163
54postsynaptic membrane organization (GO:0001941)3.02833076
55cilium morphogenesis (GO:0060271)3.01363578
56amino-acid betaine metabolic process (GO:0006577)3.01113687
57negative regulation of sodium ion transport (GO:0010766)2.99906516
58ventricular system development (GO:0021591)2.96757258
59astrocyte differentiation (GO:0048708)2.96084476
60negative regulation of neurotransmitter transport (GO:0051589)2.95536191
61left/right pattern formation (GO:0060972)2.94406503
62metanephric nephron epithelium development (GO:0072243)2.94217245
63atrial cardiac muscle cell action potential (GO:0086014)2.93957207
64photoreceptor cell maintenance (GO:0045494)2.93714288
65negative regulation of glial cell differentiation (GO:0045686)2.93557136
66positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.90525718
67negative regulation of inclusion body assembly (GO:0090084)2.89564899
68cellular component assembly involved in morphogenesis (GO:0010927)2.89374830
69negative regulation of mast cell activation (GO:0033004)2.89306838
70modified amino acid transport (GO:0072337)2.87159982
71negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.85948238
72phosphate ion transport (GO:0006817)2.85726139
73cell wall macromolecule metabolic process (GO:0044036)2.84765580
74excretion (GO:0007588)2.83720592
75microtubule bundle formation (GO:0001578)2.82881596
76diterpenoid biosynthetic process (GO:0016102)2.82438642
77regulation of beta-amyloid formation (GO:1902003)2.80663924
78positive regulation of alcohol biosynthetic process (GO:1902932)2.80025119
79cellular response to cholesterol (GO:0071397)2.79350311
80negative regulation of immunoglobulin mediated immune response (GO:0002890)2.78209083
81negative regulation of B cell mediated immunity (GO:0002713)2.78209083
82retinal cone cell development (GO:0046549)2.78078513
83negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.77483362
84thyroid hormone metabolic process (GO:0042403)2.76671263
85L-fucose catabolic process (GO:0042355)2.73844304
86fucose catabolic process (GO:0019317)2.73844304
87L-fucose metabolic process (GO:0042354)2.73844304
88locomotory exploration behavior (GO:0035641)2.73128385
89regulation of timing of cell differentiation (GO:0048505)2.72894326
90neurotransmitter catabolic process (GO:0042135)2.72475663
91cellular anion homeostasis (GO:0030002)2.70473519
92regulation of chemokine secretion (GO:0090196)2.69638321
93positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.68926492
94nonmotile primary cilium assembly (GO:0035058)2.68346502
95protein localization to cilium (GO:0061512)2.68216954
96adenine nucleotide transport (GO:0051503)2.67524440
97primary alcohol catabolic process (GO:0034310)2.67108166
98negative regulation of stress fiber assembly (GO:0051497)2.66793328
99mechanoreceptor differentiation (GO:0042490)2.66159176
100regulation of germinal center formation (GO:0002634)2.65603712
101response to auditory stimulus (GO:0010996)2.65438428
102nephron tubule development (GO:0072080)2.64974081
103hormone catabolic process (GO:0042447)2.64709381
104cGMP-mediated signaling (GO:0019934)2.64688407
105regulation of response to osmotic stress (GO:0047484)2.64527796
106thyroid hormone generation (GO:0006590)2.64081582
107negative regulation of smoothened signaling pathway (GO:0045879)2.62839201
108peptide catabolic process (GO:0043171)2.62556045
109lung epithelium development (GO:0060428)2.62302953
110metanephric epithelium development (GO:0072207)2.62125182
111cell morphogenesis involved in neuron differentiation (GO:0048667)2.61604542
112phosphate ion transmembrane transport (GO:0035435)2.61400368
113linoleic acid metabolic process (GO:0043651)2.60304538
114cell projection assembly (GO:0030031)2.59744038
115gland morphogenesis (GO:0022612)2.57102730
116membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.56001300
117cerebral cortex neuron differentiation (GO:0021895)2.53070218
118cell proliferation in forebrain (GO:0021846)2.52563960
119regulation of collateral sprouting (GO:0048670)2.52338494
120eye photoreceptor cell differentiation (GO:0001754)2.51192282
121photoreceptor cell differentiation (GO:0046530)2.51192282
122vocalization behavior (GO:0071625)2.50881131
123fructose metabolic process (GO:0006000)2.50688330
124platelet dense granule organization (GO:0060155)2.50354526
125positive regulation of positive chemotaxis (GO:0050927)2.50344396
126regulation of glomerular filtration (GO:0003093)2.49470562
127polyol transport (GO:0015791)2.48075389
128detection of light stimulus involved in sensory perception (GO:0050962)2.46885573
129detection of light stimulus involved in visual perception (GO:0050908)2.46885573
130cellular response to sterol (GO:0036315)2.45113043
131adaptation of signaling pathway (GO:0023058)2.44752982
132potassium ion homeostasis (GO:0055075)2.44319393
133neurotransmitter metabolic process (GO:0042133)2.44127730
134cellular sodium ion homeostasis (GO:0006883)2.43105011
135regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.42116180
136nephron tubule formation (GO:0072079)2.41532409
137potassium ion import (GO:0010107)2.41430055
138response to xenobiotic stimulus (GO:0009410)2.40782488
139microglial cell activation (GO:0001774)2.39823088
140glycoside metabolic process (GO:0016137)2.38414504
141urate metabolic process (GO:0046415)2.38341626
142gamma-aminobutyric acid transport (GO:0015812)2.38290820
143blood vessel maturation (GO:0001955)2.37784513
144regulation of positive chemotaxis (GO:0050926)2.37494140
145cell communication by electrical coupling (GO:0010644)2.37344900
146renal tubule development (GO:0061326)2.37028683
147retinoic acid metabolic process (GO:0042573)2.36784409
148ethanol metabolic process (GO:0006067)2.36479276
149terpenoid biosynthetic process (GO:0016114)2.35644488
150negative regulation of actin filament bundle assembly (GO:0032232)2.35572064
151dermatan sulfate metabolic process (GO:0030205)2.35487284
152cerebral cortex radially oriented cell migration (GO:0021799)2.35244973
153regulation of inositol phosphate biosynthetic process (GO:0010919)2.34659402
154regulation of hydrogen peroxide-induced cell death (GO:1903205)2.33898586
155radial glial cell differentiation (GO:0060019)2.33708406
156phenol-containing compound catabolic process (GO:0019336)2.33699796
157positive regulation of astrocyte differentiation (GO:0048711)2.33661734
158negative regulation of adenylate cyclase activity (GO:0007194)2.33604875
159low-density lipoprotein particle remodeling (GO:0034374)2.33465695
160negative regulation of humoral immune response (GO:0002921)2.33303792
161negative regulation of response to reactive oxygen species (GO:1901032)2.33077835
162oligodendrocyte differentiation (GO:0048709)2.32166182
163CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.31694447
164eosinophil chemotaxis (GO:0048245)2.30937266
165vitamin transmembrane transport (GO:0035461)2.30767382
166sodium-independent organic anion transport (GO:0043252)2.30562479
167retinal rod cell development (GO:0046548)2.30396570
168regulation of development, heterochronic (GO:0040034)2.28760863
169calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.28709567
170regulation of heat generation (GO:0031650)2.28526656
171protein heterotetramerization (GO:0051290)2.28516272
172neutral amino acid transport (GO:0015804)2.28023081
173central nervous system myelination (GO:0022010)2.27582551
174axon ensheathment in central nervous system (GO:0032291)2.27582551
175negative regulation of oligodendrocyte differentiation (GO:0048715)2.25708596
176relaxation of cardiac muscle (GO:0055119)2.25516920
177reflex (GO:0060004)2.25364923
178regulation of inclusion body assembly (GO:0090083)2.24242679
179positive regulation of oligodendrocyte differentiation (GO:0048714)2.23824868
180tolerance induction (GO:0002507)2.22837398
181regulation of neurotransmitter uptake (GO:0051580)2.21759317
182neural tube formation (GO:0001841)2.19810826

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.16445081
2AR_21572438_ChIP-Seq_LNCaP_Human2.36695211
3ZNF274_21170338_ChIP-Seq_K562_Hela2.22733888
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.20843985
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20357298
6VDR_22108803_ChIP-Seq_LS180_Human2.10279286
7SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09995277
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.07512109
9CDX2_19796622_ChIP-Seq_MESCs_Mouse2.06150217
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01704313
11TRIM28_21343339_ChIP-Seq_HEK293_Human1.98174744
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.96834784
13JARID2_20064375_ChIP-Seq_MESCs_Mouse1.90165542
14TAF15_26573619_Chip-Seq_HEK293_Human1.89680447
15EED_16625203_ChIP-ChIP_MESCs_Mouse1.87193023
16ESR2_21235772_ChIP-Seq_MCF-7_Human1.86866781
17GBX2_23144817_ChIP-Seq_PC3_Human1.85755582
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.84788429
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.84548175
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.83933187
21ZNF217_24962896_ChIP-Seq_MCF-7_Human1.83462930
22IGF1R_20145208_ChIP-Seq_DFB_Human1.80884840
23ER_23166858_ChIP-Seq_MCF-7_Human1.78955017
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.77577503
25MTF2_20144788_ChIP-Seq_MESCs_Mouse1.76480372
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.75740712
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.74555515
28RXR_22108803_ChIP-Seq_LS180_Human1.72325347
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.70269815
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.70269815
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.68904305
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.62660327
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.62328867
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.59587079
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.56906537
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.55435647
37STAT3_23295773_ChIP-Seq_U87_Human1.55027601
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.53708977
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53098588
40EZH2_27304074_Chip-Seq_ESCs_Mouse1.52561449
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.51965284
42DROSHA_22980978_ChIP-Seq_HELA_Human1.51440827
43FUS_26573619_Chip-Seq_HEK293_Human1.50749763
44IRF8_22096565_ChIP-ChIP_GC-B_Human1.49750283
45EWS_26573619_Chip-Seq_HEK293_Human1.49534216
46AHR_22903824_ChIP-Seq_MCF-7_Human1.47668649
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.43491604
48CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.43247857
49NR3C1_21868756_ChIP-Seq_MCF10A_Human1.42902207
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.41822842
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.41808821
52TCF4_23295773_ChIP-Seq_U87_Human1.41236895
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40590927
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.40541377
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39856519
56TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.38976122
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38184203
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38054009
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36036990
60RUNX2_22187159_ChIP-Seq_PCA_Human1.32358921
61TCF4_18268006_ChIP-ChIP_LS174T_Human1.31750914
62TP53_18474530_ChIP-ChIP_U2OS_Human1.30000126
63CBP_20019798_ChIP-Seq_JUKART_Human1.29879242
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29879242
65BP1_19119308_ChIP-ChIP_Hs578T_Human1.28757092
66TCF4_22108803_ChIP-Seq_LS180_Human1.26867141
67SCL_19346495_ChIP-Seq_HPC-7_Human1.26265239
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26261632
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.23673347
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.23423008
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23359322
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23226423
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.22320971
74REST_21632747_ChIP-Seq_MESCs_Mouse1.21248168
75RUNX_20019798_ChIP-Seq_JUKART_Human1.21078244
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.20293988
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20027459
78ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18648765
79RING1B_27294783_Chip-Seq_ESCs_Mouse1.18475489
80FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18267849
81ESR1_20079471_ChIP-ChIP_T-47D_Human1.18033406
82SMAD4_21799915_ChIP-Seq_A2780_Human1.17215725
83* P300_19829295_ChIP-Seq_ESCs_Human1.16886722
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16766350
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16217517
86BCAT_22108803_ChIP-Seq_LS180_Human1.15794148
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.14797447
88AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.13690025
89SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13648389
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13582352
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13017686
92NANOG_19829295_ChIP-Seq_ESCs_Human1.12615187
93SOX2_19829295_ChIP-Seq_ESCs_Human1.12615187
94PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12187848
95P53_22387025_ChIP-Seq_ESCs_Mouse1.11949563
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11535114
97EZH2_22144423_ChIP-Seq_EOC_Human1.10956788
98IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10448014
99SMAD3_21741376_ChIP-Seq_HESCs_Human1.10055645
100AR_25329375_ChIP-Seq_VCAP_Human1.08863596
101CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08819015
102PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08625547
103VDR_24787735_ChIP-Seq_THP-1_Human1.08422900
104TAL1_26923725_Chip-Seq_HPCs_Mouse1.08390047
105EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06473339
106* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06452799
107FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05791190
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05239670
109WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05096083
110NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04322334
111NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04322334
112* SOX2_21211035_ChIP-Seq_LN229_Gbm1.04203255
113* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03489967
114* FOXA1_25329375_ChIP-Seq_VCAP_Human1.03489967
115CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03439211
116AR_20517297_ChIP-Seq_VCAP_Human1.02246329
117SMAD4_21741376_ChIP-Seq_EPCs_Human1.01837451
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00930173
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00930173
120STAT3_18555785_Chip-Seq_ESCs_Mouse1.00814290
121MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99781426
122CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99474661
123FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99350496
124KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99194971
125E2F1_18555785_Chip-Seq_ESCs_Mouse0.99006252
126SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98792634
127TP53_16413492_ChIP-PET_HCT116_Human0.98713060
128SMRT_27268052_Chip-Seq_Bcells_Human0.98439394
129CDX2_22108803_ChIP-Seq_LS180_Human0.97987784
130THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97143146
131FLI1_21867929_ChIP-Seq_TH2_Mouse0.96857940
132TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95996922
133ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95966811
134ERG_21242973_ChIP-ChIP_JURKAT_Human0.95682234
135ETV1_20927104_ChIP-Seq_GIST48_Human0.94006285
136VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93861839
137TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93004258
138TP63_17297297_ChIP-ChIP_HaCaT_Human0.91921721
139TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91666946
140CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91664116
141RING1B_27294783_Chip-Seq_NPCs_Mouse0.91295905
142EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90145871
143SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89134804
144AR_19668381_ChIP-Seq_PC3_Human0.88820190
145TP63_23658742_ChIP-Seq_EP156T_Human0.88566598
146FOXO3_23340844_ChIP-Seq_DLD1_Human0.88064976
147SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87426653
148SMAD3_21741376_ChIP-Seq_EPCs_Human0.87311097
149POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86513008
150CJUN_26792858_Chip-Seq_BT549_Human0.85612071
151CDX2_20551321_ChIP-Seq_CACO-2_Human0.85599337
152SMAD4_21741376_ChIP-Seq_HESCs_Human0.85305030
153TP53_20018659_ChIP-ChIP_R1E_Mouse0.84899928
154P53_22127205_ChIP-Seq_FIBROBLAST_Human0.82504145
155TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82458350
156SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81851023
157PPAR_26484153_Chip-Seq_NCI-H1993_Human0.81294789

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.55743035
2MP0005646_abnormal_pituitary_gland3.92786335
3MP0000566_synostosis3.92348578
4MP0002653_abnormal_ependyma_morphology3.54257885
5MP0005377_hearing/vestibular/ear_phenot3.40887812
6MP0003878_abnormal_ear_physiology3.40887812
7MP0003136_yellow_coat_color3.06577682
8MP0002736_abnormal_nociception_after3.04506676
9MP0004885_abnormal_endolymph2.99387592
10MP0003690_abnormal_glial_cell2.87632632
11MP0001968_abnormal_touch/_nociception2.81049588
12MP0001958_emphysema2.61429029
13MP0004043_abnormal_pH_regulation2.55618552
14MP0008875_abnormal_xenobiotic_pharmacok2.46363771
15MP0006292_abnormal_olfactory_placode2.37931784
16MP0009780_abnormal_chondrocyte_physiolo2.28264557
17MP0001502_abnormal_circadian_rhythm2.23696182
18MP0004019_abnormal_vitamin_homeostasis2.21383820
19MP0002638_abnormal_pupillary_reflex2.16224933
20MP0009384_cardiac_valve_regurgitation2.11829897
21MP0005551_abnormal_eye_electrophysiolog2.02291004
22MP0003011_delayed_dark_adaptation1.93560764
23MP0008789_abnormal_olfactory_epithelium1.86461512
24MP0003880_abnormal_central_pattern1.85719056
25MP0001984_abnormal_olfaction1.84955524
26MP0005394_taste/olfaction_phenotype1.82018888
27MP0005499_abnormal_olfactory_system1.82018888
28MP0005332_abnormal_amino_acid1.80516151
29MP0002090_abnormal_vision1.71681390
30MP0003195_calcinosis1.71169554
31MP0002876_abnormal_thyroid_physiology1.70556038
32MP0004858_abnormal_nervous_system1.67329457
33MP0002928_abnormal_bile_duct1.64370442
34MP0004133_heterotaxia1.63510792
35MP0002132_abnormal_respiratory_system1.60226150
36MP0005253_abnormal_eye_physiology1.56964451
37MP0005423_abnormal_somatic_nervous1.54413904
38MP0001486_abnormal_startle_reflex1.52881384
39MP0001970_abnormal_pain_threshold1.50956139
40MP0001485_abnormal_pinna_reflex1.50376937
41MP0005167_abnormal_blood-brain_barrier1.49986428
42MP0002735_abnormal_chemical_nociception1.47482020
43MP0002272_abnormal_nervous_system1.43889060
44MP0005174_abnormal_tail_pigmentation1.43255359
45MP0001765_abnormal_ion_homeostasis1.41659003
46MP0003635_abnormal_synaptic_transmissio1.40772299
47MP0002734_abnormal_mechanical_nocicepti1.40356534
48MP0010030_abnormal_orbit_morphology1.40071305
49MP0004782_abnormal_surfactant_physiolog1.39919559
50MP0008872_abnormal_physiological_respon1.39871875
51MP0001986_abnormal_taste_sensitivity1.38627154
52MP0001346_abnormal_lacrimal_gland1.35524748
53MP0003075_altered_response_to1.33418956
54MP0002733_abnormal_thermal_nociception1.33334377
55MP0008961_abnormal_basal_metabolism1.32458510
56MP0002277_abnormal_respiratory_mucosa1.32240664
57MP0000049_abnormal_middle_ear1.28739838
58MP0006072_abnormal_retinal_apoptosis1.28143315
59MP0000026_abnormal_inner_ear1.25670287
60MP0009046_muscle_twitch1.24020428
61MP0003300_gastrointestinal_ulcer1.20994870
62MP0004142_abnormal_muscle_tone1.20464293
63MP0000631_abnormal_neuroendocrine_gland1.16664270
64MP0009764_decreased_sensitivity_to1.16062353
65MP0000569_abnormal_digit_pigmentation1.15381322
66MP0001963_abnormal_hearing_physiology1.13143374
67MP0001501_abnormal_sleep_pattern1.12089899
68MP0002557_abnormal_social/conspecific_i1.11444641
69MP0003303_peritoneal_inflammation1.11273194
70* MP0002136_abnormal_kidney_physiology1.10294186
71MP0001853_heart_inflammation1.09298833
72MP0000778_abnormal_nervous_system1.05923741
73MP0002229_neurodegeneration1.05527855
74MP0005645_abnormal_hypothalamus_physiol1.04871325
75MP0004270_analgesia1.04703871
76MP0009643_abnormal_urine_homeostasis1.04369347
77MP0001835_abnormal_antigen_presentation1.03408078
78MP0003633_abnormal_nervous_system1.02474088
79MP0005171_absent_coat_pigmentation1.01738400
80MP0002098_abnormal_vibrissa_morphology1.01504977
81MP0001177_atelectasis1.01249127
82MP0005388_respiratory_system_phenotype0.99255089
83MP0002133_abnormal_respiratory_system0.99255089
84MP0000465_gastrointestinal_hemorrhage0.98069739
85MP0000383_abnormal_hair_follicle0.96971440
86MP0009745_abnormal_behavioral_response0.95865528
87MP0003634_abnormal_glial_cell0.95354455
88MP0008995_early_reproductive_senescence0.94881833
89MP0001756_abnormal_urination0.94840539
90MP0001905_abnormal_dopamine_level0.94562147
91MP0005391_vision/eye_phenotype0.93040599
92MP0000427_abnormal_hair_cycle0.92969697
93MP0000428_abnormal_craniofacial_morphol0.92461056
94MP0001664_abnormal_digestion0.92260431
95MP0003183_abnormal_peptide_metabolism0.91728252
96MP0005195_abnormal_posterior_eye0.91121943
97MP0003279_aneurysm0.91115546
98MP0004215_abnormal_myocardial_fiber0.90206973
99MP0005671_abnormal_response_to0.89570988
100MP0002095_abnormal_skin_pigmentation0.89335149
101MP0003329_amyloid_beta_deposits0.87950579
102MP0002009_preneoplasia0.85095441
103MP0005636_abnormal_mineral_homeostasis0.84969088
104MP0008877_abnormal_DNA_methylation0.84212676
105MP0005166_decreased_susceptibility_to0.83472167
106MP0003938_abnormal_ear_development0.83195437
107MP0005595_abnormal_vascular_smooth0.82502717
108MP0005084_abnormal_gallbladder_morpholo0.82234702
109MP0005310_abnormal_salivary_gland0.81938036
110MP0001800_abnormal_humoral_immune0.81759551
111MP0000920_abnormal_myelination0.78963873
112MP0008569_lethality_at_weaning0.78825643
113MP0000230_abnormal_systemic_arterial0.78563536
114MP0003724_increased_susceptibility_to0.77997249
115MP0002282_abnormal_trachea_morphology0.77035823
116MP0004859_abnormal_synaptic_plasticity0.77028874
117MP0001919_abnormal_reproductive_system0.76395371
118MP0003631_nervous_system_phenotype0.76367121
119MP0002249_abnormal_larynx_morphology0.76312795
120MP0003941_abnormal_skin_development0.76040351
121MP0006276_abnormal_autonomic_nervous0.75831605
122MP0002909_abnormal_adrenal_gland0.75134889
123MP0003045_fibrosis0.75109935
124MP0004147_increased_porphyrin_level0.74404541
125MP0003638_abnormal_response/metabolism_0.73952884
126MP0002168_other_aberrant_phenotype0.73701585
127MP0001440_abnormal_grooming_behavior0.73222170
128MP0004742_abnormal_vestibular_system0.73220046
129MP0002572_abnormal_emotion/affect_behav0.71980221
130MP0004883_abnormal_blood_vessel0.71160681
131MP0005386_behavior/neurological_phenoty0.70745454
132MP0004924_abnormal_behavior0.70745454
133MP0010678_abnormal_skin_adnexa0.70488422
134MP0000647_abnormal_sebaceous_gland0.70479594
135MP0003252_abnormal_bile_duct0.70337800
136MP0000762_abnormal_tongue_morphology0.68814938
137MP0002067_abnormal_sensory_capabilities0.68359653
138MP0002063_abnormal_learning/memory/cond0.68233006
139MP0002127_abnormal_cardiovascular_syste0.67754580
140MP0000579_abnormal_nail_morphology0.64740218
141MP0002295_abnormal_pulmonary_circulatio0.63308217
142MP0003632_abnormal_nervous_system0.62420038
143MP0002089_abnormal_postnatal_growth/wei0.62146544
144MP0002233_abnormal_nose_morphology0.62094426
145MP0002064_seizures0.61906841
146MP0002138_abnormal_hepatobiliary_system0.61833518
147MP0003172_abnormal_lysosome_physiology0.61632682

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)7.47929469
2Dynein arm defect of respiratory motile cilia (HP:0012255)7.47929469
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.43968038
4Abnormal ciliary motility (HP:0012262)7.13656527
5Abnormal respiratory motile cilium morphology (HP:0005938)7.08773185
6Abnormal respiratory epithelium morphology (HP:0012253)7.08773185
7Abnormal respiratory motile cilium physiology (HP:0012261)7.04214915
8Rhinitis (HP:0012384)6.32167271
9Aplasia involving bones of the upper limbs (HP:0009823)5.86513503
10Aplasia of the phalanges of the hand (HP:0009802)5.86513503
11Aplasia involving bones of the extremities (HP:0009825)5.86513503
12Bronchiectasis (HP:0002110)4.99803500
13Chronic bronchitis (HP:0004469)4.97721003
14True hermaphroditism (HP:0010459)4.56112035
15Pancreatic fibrosis (HP:0100732)4.28073469
16Abnormality of the middle phalanges of the toes (HP:0010183)4.21645941
17Metabolic alkalosis (HP:0200114)4.12478347
18Increased circulating renin level (HP:0000848)4.11931888
19Pancreatic cysts (HP:0001737)4.10500571
20Megalencephaly (HP:0001355)4.07859794
21Polyuria (HP:0000103)3.96832934
22Abnormal urine output (HP:0012590)3.89320340
23Abnormality of renal excretion (HP:0011036)3.86375646
24Hyperactive renin-angiotensin system (HP:0000841)3.86216714
25Nasal polyposis (HP:0100582)3.75725068
26Hypomagnesemia (HP:0002917)3.75570187
27Chronic sinusitis (HP:0011109)3.65136492
28Synostosis involving the elbow (HP:0003938)3.63509601
29Humeroradial synostosis (HP:0003041)3.63509601
30Polydipsia (HP:0001959)3.57046576
31Abnormal drinking behavior (HP:0030082)3.57046576
32Hypokalemic alkalosis (HP:0001949)3.55626208
33Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)3.37169948
34Chronic otitis media (HP:0000389)3.36449487
35Bronchitis (HP:0012387)3.34834356
36Nephronophthisis (HP:0000090)3.20725264
37Onycholysis (HP:0001806)3.19174545
38Abnormality of midbrain morphology (HP:0002418)3.18124681
39Molar tooth sign on MRI (HP:0002419)3.18124681
40Medial flaring of the eyebrow (HP:0010747)3.09662598
41Cystic liver disease (HP:0006706)3.06316533
42Renal tubular acidosis (HP:0001947)3.05129340
43Abnormality of chloride homeostasis (HP:0011422)2.98879914
44Gout (HP:0001997)2.97752201
45Chronic hepatic failure (HP:0100626)2.94813702
46Abnormality of magnesium homeostasis (HP:0004921)2.92648656
47Congenital stationary night blindness (HP:0007642)2.90782814
48Hyperglycinuria (HP:0003108)2.89688415
49Recurrent sinusitis (HP:0011108)2.89444299
50Abnormality of the nasal mucosa (HP:0000433)2.88489128
51Hyperaldosteronism (HP:0000859)2.88071949
52Abnormality of the axillary hair (HP:0100134)2.85856680
53Abnormality of secondary sexual hair (HP:0009888)2.85856680
54Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.79966390
55Hyperventilation (HP:0002883)2.78740194
56Occipital encephalocele (HP:0002085)2.76150906
57Decreased central vision (HP:0007663)2.73205873
58Stomach cancer (HP:0012126)2.72581561
59Abnormality of renin-angiotensin system (HP:0000847)2.72311722
60Long nose (HP:0003189)2.70180898
61Abnormality of the nasal septum (HP:0000419)2.68280626
62Gait imbalance (HP:0002141)2.68075366
63Hemiplegia (HP:0002301)2.63537068
64Short hallux (HP:0010109)2.63178170
65Abnormality of the dental pulp (HP:0006479)2.61908823
66Proximal tubulopathy (HP:0000114)2.60871276
67Congenital primary aphakia (HP:0007707)2.59958332
68Abolished electroretinogram (ERG) (HP:0000550)2.59828012
69Congenital hepatic fibrosis (HP:0002612)2.57680755
70Renal salt wasting (HP:0000127)2.56520990
71Nephrogenic diabetes insipidus (HP:0009806)2.53680982
72Postaxial foot polydactyly (HP:0001830)2.53279857
73Abnormality of the phalanges of the 5th finger (HP:0004213)2.52963084
74Tetany (HP:0001281)2.46345989
75Decreased circulating renin level (HP:0003351)2.45712640
76Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.36805273
77Infertility (HP:0000789)2.33490332
78Confusion (HP:0001289)2.33437322
79Tubular atrophy (HP:0000092)2.32317216
80Aplasia/Hypoplasia of the hallux (HP:0008362)2.30517166
81Tubulointerstitial fibrosis (HP:0005576)2.28273854
82Adactyly (HP:0009776)2.26931305
83Mixed hearing impairment (HP:0000410)2.23157628
84Recurrent bronchitis (HP:0002837)2.22849786
85Hemiparesis (HP:0001269)2.21674384
86Aplasia/Hypoplasia of the tongue (HP:0010295)2.21447531
87Symphalangism affecting the phalanges of the hand (HP:0009773)2.20577570
88Abnormality of permanent molar morphology (HP:0011071)2.20350965
89Abnormality of the dental root (HP:0006486)2.20350965
90Taurodontia (HP:0000679)2.20350965
91Neonatal short-limb short stature (HP:0008921)2.19283701
92Split foot (HP:0001839)2.19205705
93Abnormality of the phalanges of the 2nd finger (HP:0009541)2.18856215
94Abnormal rod and cone electroretinograms (HP:0008323)2.15815820
95Abnormality of molar (HP:0011077)2.14716029
96Abnormality of molar morphology (HP:0011070)2.14716029
97Abnormality of the proximal phalanges of the hand (HP:0009834)2.14109453
98Keratoconus (HP:0000563)2.13506406
99Increased corneal curvature (HP:0100692)2.13506406
100Fibular aplasia (HP:0002990)2.12977001
101Absent rod-and cone-mediated responses on ERG (HP:0007688)2.12786009
102Genital tract atresia (HP:0001827)2.12068685
103Interstitial pulmonary disease (HP:0006530)2.11527582
104Furrowed tongue (HP:0000221)2.11157642
105Abnormality of serine family amino acid metabolism (HP:0010894)2.09914199
106Abnormality of glycine metabolism (HP:0010895)2.09914199
107Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.08898175
108Sclerocornea (HP:0000647)2.07750756
109Progressive cerebellar ataxia (HP:0002073)2.06939621
110Morphological abnormality of the middle ear (HP:0008609)2.06465423
111Diplopia (HP:0000651)2.06351754
112Abnormality of binocular vision (HP:0011514)2.06351754
113Male pseudohermaphroditism (HP:0000037)2.04137518
114Abnormality of the renal medulla (HP:0100957)2.02683010
115Asplenia (HP:0001746)2.02406996
116Septo-optic dysplasia (HP:0100842)2.00897952
117Abnormality of the middle phalanges of the hand (HP:0009833)2.00854220
118Attenuation of retinal blood vessels (HP:0007843)2.00273709
119Vaginal atresia (HP:0000148)1.99992285
120Focal motor seizures (HP:0011153)1.99955476
121Abnormality of the renal cortex (HP:0011035)1.99225462
122Postaxial hand polydactyly (HP:0001162)1.98853076
123Increased purine levels (HP:0004368)1.98695603
124Hyperuricemia (HP:0002149)1.98695603
125Aplasia/Hypoplasia of the spleen (HP:0010451)1.98369479
126Lip pit (HP:0100267)1.97907473
127Bifid scrotum (HP:0000048)1.96168234
128Abnormality of macular pigmentation (HP:0008002)1.92221568
129Median cleft lip (HP:0000161)1.91439896
130Blepharitis (HP:0000498)1.89298396
131Tubulointerstitial abnormality (HP:0001969)1.87275909
132Nasolacrimal duct obstruction (HP:0000579)1.86362819
133Recurrent otitis media (HP:0000403)1.86057622
134Clumsiness (HP:0002312)1.84701348
135Abnormality of the costochondral junction (HP:0000919)1.83122060
136Urethral obstruction (HP:0000796)1.83000317
137Neurofibrillary tangles (HP:0002185)1.81715281
138Anencephaly (HP:0002323)1.81534153
139Hydroxyprolinuria (HP:0003080)1.80017377
140Abnormality of proline metabolism (HP:0010907)1.80017377
141Nephropathy (HP:0000112)1.79839536
142Hypercalciuria (HP:0002150)1.79708584
143Absent toe (HP:0010760)1.79274478
144Tubulointerstitial nephritis (HP:0001970)1.78106528
145Short middle phalanx of finger (HP:0005819)1.77066603
146Pigmentary retinal degeneration (HP:0001146)1.77045383
147Widely spaced teeth (HP:0000687)1.76604263
148Bile duct proliferation (HP:0001408)1.75691352
149Abnormal biliary tract physiology (HP:0012439)1.75691352
150Elevated erythrocyte sedimentation rate (HP:0003565)1.75500967
151Absent speech (HP:0001344)1.75284399
152Gaze-evoked nystagmus (HP:0000640)1.74967322
153Ketoacidosis (HP:0001993)1.74387783
154Large for gestational age (HP:0001520)1.74272675
155Broad hallux (HP:0010055)1.72830027
156Nephrocalcinosis (HP:0000121)1.72674164
157Back pain (HP:0003418)1.71594844
158Hypokalemia (HP:0002900)1.71573544
159Sensorimotor neuropathy (HP:0007141)1.71458812
160Hyperkalemia (HP:0002153)1.70044582
161Abnormality of the distal phalanges of the toes (HP:0010182)1.70014237
162Synostosis of carpal bones (HP:0005048)1.69994141
163Widely patent fontanelles and sutures (HP:0004492)1.69966950
164Febrile seizures (HP:0002373)1.69955270
165Poor coordination (HP:0002370)1.66886439
166Short middle phalanx of the 5th finger (HP:0004220)1.66425952
167Abnormality of nail color (HP:0100643)1.65934196
168Abnormality of the fingertips (HP:0001211)1.65031989
169Oculomotor apraxia (HP:0000657)1.64111712
170Type II lissencephaly (HP:0007260)1.62155510
171Bony spicule pigmentary retinopathy (HP:0007737)1.55216728
172Polyphagia (HP:0002591)1.52505674
173Supernumerary spleens (HP:0009799)1.48521471
174Renal cortical cysts (HP:0000803)1.47569170
175Aplasia/Hypoplasia of the tibia (HP:0005772)1.44901002
176Central scotoma (HP:0000603)1.44731990

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.44957992
2SIK13.11150856
3PNCK3.04461243
4TNIK3.00883560
5INSRR2.96959228
6IRAK32.95201671
7MUSK2.88532723
8LMTK22.87736290
9SGK22.61850608
10WNK32.55847955
11NTRK22.28103661
12NTRK32.14782396
13SGK4942.13950669
14SGK2232.13950669
15PHKG22.11084758
16PHKG12.11084758
17SGK32.00372769
18MAP4K21.98692989
19TLK11.90684753
20OXSR11.88435793
21CAMK1D1.87272479
22MAPK151.84776739
23WNK41.81189066
24LATS11.78948870
25ADRBK21.77407402
26MKNK21.75416207
27EPHA21.54372364
28CDK31.46274124
29BLK1.42569897
30MST41.38010980
31ACVR1B1.37607131
32CAMK1G1.37605880
33FGFR31.34262045
34EPHB11.32881799
35PTK2B1.29716047
36TSSK61.28232688
37FES1.26455199
38STK391.23100711
39STK38L1.16768402
40CASK1.15402570
41NLK1.11865452
42PRKD31.09639888
43CDK91.08561255
44MAPK131.08195484
45MAPK71.03418440
46ERBB31.03296832
47GRK11.02490417
48FGFR21.02216359
49EPHA41.02123393
50EPHA31.02017959
51EPHB20.98048083
52HIPK20.97054204
53MAPKAPK30.97013824
54MAPK120.94631418
55PINK10.93339568
56STK380.91344455
57PRKCE0.90867065
58DAPK20.89953915
59RIPK40.89344614
60ERBB20.88955935
61PKN10.88675126
62WEE10.87902906
63BMPR1B0.84120320
64MAPKAPK50.84003276
65IRAK10.82548097
66MAP3K70.80031410
67TNK20.78043323
68PIK3CA0.77221308
69SGK10.77180803
70PRKCQ0.76765289
71MAP3K20.76235866
72JAK30.75833059
73KIT0.74099840
74GRK60.73167960
75ITK0.71925199
76MAP3K130.70771800
77MAP3K30.69768035
78MAP3K40.69304808
79TGFBR20.68209995
80SYK0.67038143
81LYN0.64600687
82DYRK20.64552684
83CAMKK20.63595459
84PRKAA20.62596757
85CAMK10.62010520
86ROCK10.61778374
87PDK20.60575889
88GRK70.59329428
89PAK30.59037384
90LRRK20.58948013
91DYRK1A0.58737321
92PLK20.58654609
93NEK60.58248578
94MAP3K140.57510434
95TRPM70.57136434
96CSNK1G20.57081852
97IGF1R0.56643049
98YES10.56109004
99CAMK40.56052327
100PRKD20.55277120
101TXK0.54041032
102PBK0.53708649
103MARK20.52349981
104EIF2AK30.52204764
105BTK0.51006791
106CSNK1G10.50963954
107CSF1R0.50268946
108SIK20.50056700
109ZAK0.50045326
110IRAK20.49999850
111IKBKB0.49572234
112CHUK0.48190594
113MAP2K20.47636546
114CAMK2A0.47561177
115PDGFRB0.47307963
116TIE10.45337151
117BRSK20.45223561
118DYRK30.44975027
119RPS6KA40.44902726
120ABL10.44899851
121BMPR20.44225181
122FGR0.43962131
123STK100.43242489
124NUAK10.42889350
125FGFR40.42649653
126STK110.42602796
127MARK10.42551895
128TRIB30.41874985
129CDK80.41220037
130PRKAA10.40786768
131RIPK10.40270122
132MAP2K70.39300714
133JAK10.38816861
134TEC0.38812996
135FER0.38615947
136PRKG10.38230249
137CAMKK10.38069076
138GSK3A0.37993259
139ADRBK10.37825706
140STK240.36814235
141BCKDK0.36374229
142TAOK30.35906866
143CSK0.35774852
144RPS6KB20.35693057
145HCK0.35661450
146PTK60.35289738
147PRKACA0.35179661
148PIK3CG0.35079573
149VRK10.35056006

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.49307645
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.36032347
3Nitrogen metabolism_Homo sapiens_hsa009103.19268182
4Linoleic acid metabolism_Homo sapiens_hsa005912.34416394
5Phototransduction_Homo sapiens_hsa047442.34360165
6Asthma_Homo sapiens_hsa053102.26945087
7Histidine metabolism_Homo sapiens_hsa003402.25457785
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.19534702
9Fatty acid metabolism_Homo sapiens_hsa012122.13432214
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.98391049
11Fatty acid degradation_Homo sapiens_hsa000711.95287759
12Circadian rhythm_Homo sapiens_hsa047101.94334912
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.85874166
14Mineral absorption_Homo sapiens_hsa049781.78992647
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.76906706
16Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.75572494
17Vitamin digestion and absorption_Homo sapiens_hsa049771.72676826
18Allograft rejection_Homo sapiens_hsa053301.54160786
19Gastric acid secretion_Homo sapiens_hsa049711.47653180
20Autoimmune thyroid disease_Homo sapiens_hsa053201.42093881
21PPAR signaling pathway_Homo sapiens_hsa033201.39976568
22Propanoate metabolism_Homo sapiens_hsa006401.39841619
23Type I diabetes mellitus_Homo sapiens_hsa049401.35202457
24Bile secretion_Homo sapiens_hsa049761.33149531
25Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.32756597
26Graft-versus-host disease_Homo sapiens_hsa053321.32671396
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.28989543
28Salivary secretion_Homo sapiens_hsa049701.22737000
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.22567005
30Staphylococcus aureus infection_Homo sapiens_hsa051501.20094537
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17111708
32Peroxisome_Homo sapiens_hsa041461.15640395
33Sulfur metabolism_Homo sapiens_hsa009201.14375128
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11460927
35Arachidonic acid metabolism_Homo sapiens_hsa005901.09537575
36Tryptophan metabolism_Homo sapiens_hsa003801.08362414
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.07819813
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.07774943
39Chemical carcinogenesis_Homo sapiens_hsa052041.05324395
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.05161855
41Antigen processing and presentation_Homo sapiens_hsa046121.02367783
42Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00523585
43Glutamatergic synapse_Homo sapiens_hsa047240.99682237
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98957104
45Butanoate metabolism_Homo sapiens_hsa006500.98664048
46Steroid hormone biosynthesis_Homo sapiens_hsa001400.97320756
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96417824
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.96025838
49GABAergic synapse_Homo sapiens_hsa047270.95829529
50Olfactory transduction_Homo sapiens_hsa047400.94310459
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94110423
52Nicotine addiction_Homo sapiens_hsa050330.93984410
53Basal cell carcinoma_Homo sapiens_hsa052170.92991308
54Amphetamine addiction_Homo sapiens_hsa050310.92553164
55Lysine degradation_Homo sapiens_hsa003100.91997805
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89588942
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85557489
58Serotonergic synapse_Homo sapiens_hsa047260.85005217
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84850437
60Insulin secretion_Homo sapiens_hsa049110.84274227
61Caffeine metabolism_Homo sapiens_hsa002320.84246060
62Dorso-ventral axis formation_Homo sapiens_hsa043200.84116912
63beta-Alanine metabolism_Homo sapiens_hsa004100.83608709
64cAMP signaling pathway_Homo sapiens_hsa040240.83390169
65Long-term depression_Homo sapiens_hsa047300.82218208
66Other glycan degradation_Homo sapiens_hsa005110.80045978
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.79087054
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76730340
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76457356
70Oxytocin signaling pathway_Homo sapiens_hsa049210.75918857
71Circadian entrainment_Homo sapiens_hsa047130.74933482
72Glutathione metabolism_Homo sapiens_hsa004800.74289848
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.74105626
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73769052
75Ovarian steroidogenesis_Homo sapiens_hsa049130.72420365
76Choline metabolism in cancer_Homo sapiens_hsa052310.72292678
77ABC transporters_Homo sapiens_hsa020100.71298456
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70900880
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70870541
80Rheumatoid arthritis_Homo sapiens_hsa053230.70595348
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69437056
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68026630
83Fructose and mannose metabolism_Homo sapiens_hsa000510.66845893
84Calcium signaling pathway_Homo sapiens_hsa040200.66516147
85Lysosome_Homo sapiens_hsa041420.66058077
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65349065
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65312856
88Insulin resistance_Homo sapiens_hsa049310.65232913
89Starch and sucrose metabolism_Homo sapiens_hsa005000.64096663
90Pancreatic secretion_Homo sapiens_hsa049720.63555795
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.60432680
92Cocaine addiction_Homo sapiens_hsa050300.60250059
93Leishmaniasis_Homo sapiens_hsa051400.59789706
94Thyroid hormone synthesis_Homo sapiens_hsa049180.58890510
95Estrogen signaling pathway_Homo sapiens_hsa049150.57357706
96Protein digestion and absorption_Homo sapiens_hsa049740.56739347
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.56382572
98Morphine addiction_Homo sapiens_hsa050320.55488516
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55297641
100Glycerolipid metabolism_Homo sapiens_hsa005610.55084983
101Tyrosine metabolism_Homo sapiens_hsa003500.55067794
102Melanogenesis_Homo sapiens_hsa049160.54782917
103Renin secretion_Homo sapiens_hsa049240.54645757
104Ether lipid metabolism_Homo sapiens_hsa005650.54180236
105Hippo signaling pathway_Homo sapiens_hsa043900.53230456
106Inositol phosphate metabolism_Homo sapiens_hsa005620.53224760
107Retinol metabolism_Homo sapiens_hsa008300.53190959
108Sphingolipid metabolism_Homo sapiens_hsa006000.53012616
109Taste transduction_Homo sapiens_hsa047420.52098899
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50874674
111Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50839813
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.50485580
113Dopaminergic synapse_Homo sapiens_hsa047280.49342091
114Primary immunodeficiency_Homo sapiens_hsa053400.48156353
115Hematopoietic cell lineage_Homo sapiens_hsa046400.47668348
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47146741
117Steroid biosynthesis_Homo sapiens_hsa001000.46402749
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.46127164
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45777798
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45420725
121Platelet activation_Homo sapiens_hsa046110.44277487
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44177131
123Galactose metabolism_Homo sapiens_hsa000520.44072781
124Hepatitis C_Homo sapiens_hsa051600.43903393
125Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43826985
126Leukocyte transendothelial migration_Homo sapiens_hsa046700.43649558
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43570680
128Rap1 signaling pathway_Homo sapiens_hsa040150.43460452
129Cholinergic synapse_Homo sapiens_hsa047250.42378258
130Adherens junction_Homo sapiens_hsa045200.42171363
131Regulation of autophagy_Homo sapiens_hsa041400.41965672
132African trypanosomiasis_Homo sapiens_hsa051430.41415643
133Notch signaling pathway_Homo sapiens_hsa043300.41240548
134Arginine and proline metabolism_Homo sapiens_hsa003300.39253227
135FoxO signaling pathway_Homo sapiens_hsa040680.39110143
136Hedgehog signaling pathway_Homo sapiens_hsa043400.39096553
137Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39028606
138Fatty acid elongation_Homo sapiens_hsa000620.36145666
139Jak-STAT signaling pathway_Homo sapiens_hsa046300.32938329

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