SLC15A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by organism of defense response of other organism involved in symbiotic interact7.19282294
2modulation by symbiont of host immune response (GO:0052553)7.19282294
3positive regulation by symbiont of host defense response (GO:0052509)7.19282294
4modulation by symbiont of host defense response (GO:0052031)7.19282294
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:007.19282294
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:07.19282294
7response to peptidoglycan (GO:0032494)5.48056233
8neutrophil activation involved in immune response (GO:0002283)5.32367787
9macrophage activation involved in immune response (GO:0002281)5.18580471
10response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.80621228
11response to host immune response (GO:0052572)4.80621228
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.79785931
13positive regulation of interferon-alpha production (GO:0032727)4.70711181
14regulation of interferon-beta biosynthetic process (GO:0045357)4.64015917
15regulation of interferon-alpha production (GO:0032647)4.50533010
16respiratory burst (GO:0045730)4.48162791
17microglial cell activation (GO:0001774)4.47321629
18positive regulation of chemokine biosynthetic process (GO:0045080)4.47263091
19immunoglobulin mediated immune response (GO:0016064)4.42322699
20positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.36361007
21response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.29561636
22response to host (GO:0075136)4.29561636
23response to host defenses (GO:0052200)4.29561636
24positive regulation of heat generation (GO:0031652)4.21959946
25lipopolysaccharide-mediated signaling pathway (GO:0031663)4.17205146
26response to muramyl dipeptide (GO:0032495)4.08619422
27granulocyte activation (GO:0036230)4.03554520
28positive regulation of cellular amide metabolic process (GO:0034250)4.02524712
29hydrogen peroxide biosynthetic process (GO:0050665)3.99886574
30positive regulation of antigen processing and presentation (GO:0002579)3.99476251
31glycosphingolipid catabolic process (GO:0046479)3.93641100
32regulation of fever generation (GO:0031620)3.87093151
33regulation of dendritic cell antigen processing and presentation (GO:0002604)3.86311611
34detection of other organism (GO:0098543)3.84884366
35positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.80880417
36neutrophil activation (GO:0042119)3.79594620
37amino sugar catabolic process (GO:0046348)3.72796554
38macrophage activation (GO:0042116)3.72363873
39oligosaccharide catabolic process (GO:0009313)3.70420110
40myeloid cell activation involved in immune response (GO:0002275)3.68378104
41superoxide anion generation (GO:0042554)3.65019689
42natural killer cell mediated immunity (GO:0002228)3.62485886
43natural killer cell mediated cytotoxicity (GO:0042267)3.62485886
44detection of bacterium (GO:0016045)3.58590411
45cellular response to thyroid hormone stimulus (GO:0097067)3.56676779
46positive regulation of mast cell degranulation (GO:0043306)3.55979515
47positive regulation of mast cell activation involved in immune response (GO:0033008)3.55979515
48regulation of mononuclear cell migration (GO:0071675)3.55734842
49positive regulation of gamma-delta T cell activation (GO:0046645)3.55376713
50regulation of chemokine biosynthetic process (GO:0045073)3.53722644
51glycolipid catabolic process (GO:0019377)3.52388944
52detection of external biotic stimulus (GO:0098581)3.50992543
53reactive oxygen species biosynthetic process (GO:1903409)3.49062438
54cellular response to type I interferon (GO:0071357)3.45770051
55type I interferon signaling pathway (GO:0060337)3.45770051
56negative regulation of interleukin-12 production (GO:0032695)3.43995632
57regulation of mast cell degranulation (GO:0043304)3.43937739
58response to type I interferon (GO:0034340)3.42829323
59positive regulation of interferon-beta production (GO:0032728)3.41721584
60positive regulation of mast cell activation (GO:0033005)3.41236515
61regulation of antigen processing and presentation (GO:0002577)3.38467334
62positive regulation of toll-like receptor signaling pathway (GO:0034123)3.29310479
63positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.28790131
64B cell mediated immunity (GO:0019724)3.26352733
65detection of molecule of bacterial origin (GO:0032490)3.23984614
66myeloid dendritic cell activation (GO:0001773)3.23892513
67negative regulation of interleukin-17 production (GO:0032700)3.22337102
68regulation of mast cell activation involved in immune response (GO:0033006)3.22031953
69interferon-gamma-mediated signaling pathway (GO:0060333)3.21801437
70T-helper 1 type immune response (GO:0042088)3.21528853
71regulation of interleukin-8 biosynthetic process (GO:0045414)3.20981953
72regulation of vitamin D biosynthetic process (GO:0060556)3.20965941
73positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.20768256
74defense response to protozoan (GO:0042832)3.19827892
75cellular extravasation (GO:0045123)3.19203257
76antigen processing and presentation of endogenous antigen (GO:0019883)3.18934358
77I-kappaB phosphorylation (GO:0007252)3.17477864
78leukocyte aggregation (GO:0070486)3.17247814
79regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.16942450
80regulation of gamma-delta T cell activation (GO:0046643)3.16388850
81negative regulation of cytokine production involved in immune response (GO:0002719)3.15349263
82regulation of heat generation (GO:0031650)3.14270418
83positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.13940238
84antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.12368054
85antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.12368054
86neutrophil mediated immunity (GO:0002446)3.12199518
87detection of biotic stimulus (GO:0009595)3.11908462
88positive regulation of interleukin-12 production (GO:0032735)3.10066179
89ceramide catabolic process (GO:0046514)3.09931181
90low-density lipoprotein particle clearance (GO:0034383)3.09857789
91regulation of leukocyte degranulation (GO:0043300)3.09536279
92response to protozoan (GO:0001562)3.08893915
93positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.08527559
94leukocyte mediated cytotoxicity (GO:0001909)3.07803513
95monocyte chemotaxis (GO:0002548)3.07372346
96positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.07008889
97regulation of mast cell activation (GO:0033003)3.00961664
98positive regulation of chemokine production (GO:0032722)3.00455295
99regulation of cholesterol storage (GO:0010885)3.00354562
100regulation of myeloid leukocyte mediated immunity (GO:0002886)2.99924112
101NIK/NF-kappaB signaling (GO:0038061)2.99916840
102eosinophil chemotaxis (GO:0048245)2.99704000
103regulation of B cell receptor signaling pathway (GO:0050855)2.99235944
104negative regulation of myeloid cell apoptotic process (GO:0033033)2.99043285
105negative regulation of cell killing (GO:0031342)2.98709231
106negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.98709231
107positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.98239905
108myeloid dendritic cell differentiation (GO:0043011)2.95992615
109N-acetylneuraminate metabolic process (GO:0006054)2.95955640
110regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.95165392
111regulation of T-helper 1 cell differentiation (GO:0045625)2.94952648
112positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.93589490
113negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.91704098
114cytokine secretion (GO:0050663)2.91125910
115regulation of T-helper 2 cell differentiation (GO:0045628)2.91092227
116germinal center formation (GO:0002467)2.90759404
117positive regulation of NF-kappaB import into nucleus (GO:0042346)2.89676570
118positive regulation of leukocyte degranulation (GO:0043302)2.89406049
119regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.89278117
120regulation of interleukin-17 production (GO:0032660)2.89011412
121regulation of T cell tolerance induction (GO:0002664)2.88215516
122negative regulation of erythrocyte differentiation (GO:0045647)2.88212809
123negative regulation of viral genome replication (GO:0045071)2.88100652
124regulation of podosome assembly (GO:0071801)2.87555746
125positive regulation of type 2 immune response (GO:0002830)2.86096730
126regulation of interleukin-12 production (GO:0032655)2.84892403
127dendritic cell differentiation (GO:0097028)2.84582378
128cellular response to interferon-gamma (GO:0071346)2.83706431
129regulation of macrophage chemotaxis (GO:0010758)2.79328438
130positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.77624617
131positive regulation of monocyte chemotaxis (GO:0090026)2.76149735
132response to thyroid hormone (GO:0097066)2.72771195

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_21731497_ChIP-ChIP_J774_Mouse7.22346267
2* IRF8_22096565_ChIP-ChIP_GC-B_Human6.65706921
3BP1_19119308_ChIP-ChIP_Hs578T_Human6.55571522
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.81960447
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.57002035
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse4.12601395
7* IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.10050360
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.97709307
9* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.91966394
10RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.22324593
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.21042305
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.13295456
13MYB_21317192_ChIP-Seq_ERMYB_Mouse3.01342904
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.97479683
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.92493379
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.77037430
17* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.53838947
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.53124236
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.42122107
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.32055044
21BRD4_27068464_Chip-Seq_AML-cells_Mouse2.18104648
22* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.07133538
23* SPI1_23547873_ChIP-Seq_NB4_Human2.04923501
24VDR_24787735_ChIP-Seq_THP-1_Human1.96042171
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.85325343
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.84786071
27VDR_24763502_ChIP-Seq_THP-1_Human1.84627879
28SPI1_23127762_ChIP-Seq_K562_Human1.82913378
29PU_27001747_Chip-Seq_BMDM_Mouse1.80041358
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.78927415
31CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.76274671
32PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.75460824
33LXR_22292898_ChIP-Seq_THP-1_Human1.74364970
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.65648013
35MYC_22102868_ChIP-Seq_BL_Human1.64890831
36* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.64764781
37RUNX_20019798_ChIP-Seq_JUKART_Human1.64697697
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.59133573
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.58251301
40SCL_19346495_ChIP-Seq_HPC-7_Human1.52140635
41MYB_26560356_Chip-Seq_TH2_Human1.49984214
42NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.49935552
43MAF_26560356_Chip-Seq_TH1_Human1.47975880
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.42929705
45* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40917876
46VDR_21846776_ChIP-Seq_THP-1_Human1.38817318
47CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38693627
48* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37022362
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36874545
50CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31705917
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29601500
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.25527110
53* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.22963374
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.21718169
55MYB_26560356_Chip-Seq_TH1_Human1.21138708
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.21087964
57PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19803874
58IKZF1_21737484_ChIP-ChIP_HCT116_Human1.19760501
59SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19288238
60GATA1_22025678_ChIP-Seq_K562_Human1.18501675
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17028285
62GATA1_19941826_ChIP-Seq_K562_Human1.14756158
63PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13976700
64CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08806667
65GATA3_26560356_Chip-Seq_TH2_Human1.07688853
66BCL6_27268052_Chip-Seq_Bcells_Human1.07304486
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07004274
68BCOR_27268052_Chip-Seq_Bcells_Human1.02666023
69* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01747807
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00616794
71PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00148283
72* GATA3_27048872_Chip-Seq_THYMUS_Human1.00008589
73GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98780900
74UTX_26944678_Chip-Seq_JUKART_Human0.97074989
75STAT1_20625510_ChIP-Seq_HELA_Human0.94620999
76* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94498137
77TCF7_22412390_ChIP-Seq_EML_Mouse0.94429132
78FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93821166
79ELK3_25401928_ChIP-Seq_HUVEC_Human0.93209972
80EGR1_19032775_ChIP-ChIP_M12_Human0.93197060
81PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.92156888
82KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92033138
83VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90408515
84KDM2B_26808549_Chip-Seq_K562_Human0.89029034
85NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88734227
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88734227
87ESR2_21235772_ChIP-Seq_MCF-7_Human0.87730652
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87542373
89* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86251681
90CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.86149556
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86072052
92GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85714024
93TP63_17297297_ChIP-ChIP_HaCaT_Human0.85671021
94RACK7_27058665_Chip-Seq_MCF-7_Human0.85038767
95ELF1_20517297_ChIP-Seq_JURKAT_Human0.84407950
96KDM2B_26808549_Chip-Seq_JURKAT_Human0.83136868
97LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.82945042
98NCOR1_26117541_ChIP-Seq_K562_Human0.82497742
99TFEB_21752829_ChIP-Seq_HELA_Human0.80555841
100SOX2_20726797_ChIP-Seq_SW620_Human0.77524459
101GATA1_19941827_ChIP-Seq_MEL_Mouse0.76907058
102* MAF_26560356_Chip-Seq_TH2_Human0.74376071
103CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.71566032
104GATA2_19941826_ChIP-Seq_K562_Human0.70512479
105JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.70330268
106GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70238692
107JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.70073748
108SPI1_20517297_ChIP-Seq_HL60_Human0.68687870
109GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67974558
110TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.66591462
111KDM2B_26808549_Chip-Seq_DND41_Human0.66367858
112TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.65524363
113GATA1_22383799_ChIP-Seq_G1ME_Mouse0.63831109
114RARG_19884340_ChIP-ChIP_MEFs_Mouse0.63685511
115GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.62812323
116CJUN_26792858_Chip-Seq_BT549_Human0.62558223
117SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.61085449
118SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.61085449
119SMRT_27268052_Chip-Seq_Bcells_Human0.60818393
120KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.60148890
121ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.59916894

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.51517850
2MP0001835_abnormal_antigen_presentation4.13603405
3MP0003436_decreased_susceptibility_to3.86677321
4MP0009785_altered_susceptibility_to3.71234465
5MP0006082_CNS_inflammation3.37266415
6MP0004510_myositis3.34490126
7MP0005058_abnormal_lysosome_morphology3.28856858
8MP0002148_abnormal_hypersensitivity_rea3.28451282
9MP0002419_abnormal_innate_immunity3.27976721
10MP0005000_abnormal_immune_tolerance3.15297370
11MP0001790_abnormal_immune_system2.91437251
12MP0005387_immune_system_phenotype2.91437251
13MP0005025_abnormal_response_to2.90375553
14MP0003724_increased_susceptibility_to2.87163993
15MP0002452_abnormal_antigen_presenting2.63784871
16MP0000685_abnormal_immune_system2.48889270
17MP0001800_abnormal_humoral_immune2.45975424
18MP0002723_abnormal_immune_serum2.45866304
19MP0005671_abnormal_response_to2.40069033
20MP0003172_abnormal_lysosome_physiology2.38436383
21MP0001533_abnormal_skeleton_physiology2.18385817
22MP0001819_abnormal_immune_cell2.14435206
23MP0004947_skin_inflammation2.14149199
24MP0002420_abnormal_adaptive_immunity2.10977703
25MP0005464_abnormal_platelet_physiology2.07970933
26MP0002139_abnormal_hepatobiliary_system2.00118913
27MP0009278_abnormal_bone_marrow1.99844203
28MP0000569_abnormal_digit_pigmentation1.99232255
29MP0003448_altered_tumor_morphology1.96426993
30MP0002405_respiratory_system_inflammati1.88961572
31MP0009764_decreased_sensitivity_to1.88921032
32MP0009840_abnormal_foam_cell1.88739817
33MP0001845_abnormal_inflammatory_respons1.85981159
34MP0005451_abnormal_body_composition1.83477384
35MP0003075_altered_response_to1.81908622
36MP0000343_altered_response_to1.75431927
37MP0003191_abnormal_cellular_cholesterol1.74582619
38MP0008469_abnormal_protein_level1.72452619
39MP0001853_heart_inflammation1.72268616
40MP0000604_amyloidosis1.71554633
41MP0005257_abnormal_intraocular_pressure1.61953389
42MP0002998_abnormal_bone_remodeling1.60556348
43MP0005310_abnormal_salivary_gland1.48761067
44MP0010155_abnormal_intestine_physiology1.48264141
45MP0000716_abnormal_immune_system1.45790189
46MP0003806_abnormal_nucleotide_metabolis1.44806102
47MP0003183_abnormal_peptide_metabolism1.44716472
48MP0004858_abnormal_nervous_system1.40772882
49MP0003300_gastrointestinal_ulcer1.36100015
50MP0009333_abnormal_splenocyte_physiolog1.34120599
51MP0002398_abnormal_bone_marrow1.31664365
52MP0002254_reproductive_system_inflammat1.31066467
53MP0005166_decreased_susceptibility_to1.30150312
54MP0000858_altered_metastatic_potential1.28754018
55MP0005167_abnormal_blood-brain_barrier1.28682260
56MP0008004_abnormal_stomach_pH1.28153100
57MP0003690_abnormal_glial_cell1.28112922
58MP0002277_abnormal_respiratory_mucosa1.25812502
59MP0001545_abnormal_hematopoietic_system1.25097516
60MP0005397_hematopoietic_system_phenotyp1.25097516
61MP0002006_tumorigenesis1.23216432
62MP0003329_amyloid_beta_deposits1.18242000
63MP0000689_abnormal_spleen_morphology1.17395533
64MP0005076_abnormal_cell_differentiation1.17056624
65MP0008260_abnormal_autophagy1.15103206
66MP0002429_abnormal_blood_cell1.13263785
67MP0001851_eye_inflammation1.12264186
68MP0005164_abnormal_response_to1.11504240
69MP0010307_abnormal_tumor_latency1.07657321
70MP0005174_abnormal_tail_pigmentation1.07537705
71MP0005390_skeleton_phenotype1.02607002
72MP0002722_abnormal_immune_system1.01579134
73MP0002933_joint_inflammation0.99807985
74MP0006054_spinal_hemorrhage0.99469296
75MP0003828_pulmonary_edema0.97717663
76MP0004782_abnormal_surfactant_physiolog0.96020212
77MP0009763_increased_sensitivity_to0.95639580
78MP0003195_calcinosis0.92939429
79MP0002138_abnormal_hepatobiliary_system0.92357732
80MP0003453_abnormal_keratinocyte_physiol0.85591083
81MP0005083_abnormal_biliary_tract0.84285316
82MP0000465_gastrointestinal_hemorrhage0.83690038
83MP0003763_abnormal_thymus_physiology0.79588337
84MP0000015_abnormal_ear_pigmentation0.78860247
85MP0003091_abnormal_cell_migration0.78843189
86MP0002332_abnormal_exercise_endurance0.78696414
87MP0000371_diluted_coat_color0.76944767
88MP0003186_abnormal_redox_activity0.76340899
89MP0003566_abnormal_cell_adhesion0.76267086
90MP0000249_abnormal_blood_vessel0.74541850
91MP0002166_altered_tumor_susceptibility0.72385935
92MP0005365_abnormal_bile_salt0.72138943
93MP0005165_increased_susceptibility_to0.71882964
94MP0008874_decreased_physiological_sensi0.71570682
95MP0001542_abnormal_bone_strength0.70833848
96MP0001501_abnormal_sleep_pattern0.70668254
97MP0009765_abnormal_xenobiotic_induced0.68150419
98MP0003656_abnormal_erythrocyte_physiolo0.67909870
99MP0003795_abnormal_bone_structure0.67353605
100MP0003279_aneurysm0.63014910
101MP0002877_abnormal_melanocyte_morpholog0.61455439
102MP0005647_abnormal_sex_gland0.61425815
103MP0001873_stomach_inflammation0.60167846
104MP0001663_abnormal_digestive_system0.59328812
105MP0002090_abnormal_vision0.58154640
106MP0002136_abnormal_kidney_physiology0.57473320
107MP0005319_abnormal_enzyme/_coenzyme0.57060853
108MP0005197_abnormal_uvea_morphology0.54980887
109MP0000767_abnormal_smooth_muscle0.54976954
110MP0003866_abnormal_defecation0.54840249
111MP0000920_abnormal_myelination0.54663585
112MP0001958_emphysema0.54150277
113MP0000490_abnormal_crypts_of0.54062373
114MP0001849_ear_inflammation0.53754918
115MP0000609_abnormal_liver_physiology0.53484765
116MP0003045_fibrosis0.53461833
117MP0003634_abnormal_glial_cell0.53114350
118MP0003646_muscle_fatigue0.52346348
119MP0005023_abnormal_wound_healing0.51712112
120MP0004883_abnormal_blood_vessel0.51636862
121MP0010352_gastrointestinal_tract_polyps0.51622196
122MP0010386_abnormal_urinary_bladder0.51239796
123MP0004808_abnormal_hematopoietic_stem0.50205575

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.33676438
2Eczematoid dermatitis (HP:0000976)6.98930733
3Recurrent bacterial skin infections (HP:0005406)6.59813576
4Recurrent gram-negative bacterial infections (HP:0005420)6.22977468
5Abnormality of macrophages (HP:0004311)5.57388532
6Mediastinal lymphadenopathy (HP:0100721)5.24380367
7Increased cerebral lipofuscin (HP:0011813)5.00413360
8Stomatitis (HP:0010280)4.95802148
9Elevated erythrocyte sedimentation rate (HP:0003565)4.59190257
10Increased neuronal autofluorescent lipopigment (HP:0002074)4.42115185
11Vacuolated lymphocytes (HP:0001922)4.41467895
12Systemic lupus erythematosus (HP:0002725)4.39373295
13Orchitis (HP:0100796)4.30660192
14Autoimmune thrombocytopenia (HP:0001973)4.25230807
15Retrobulbar optic neuritis (HP:0100654)4.19467149
16Optic neuritis (HP:0100653)4.19467149
17Gingivitis (HP:0000230)4.14795606
18Myositis (HP:0100614)4.13999782
19Recurrent skin infections (HP:0001581)4.04671094
20Obstructive lung disease (HP:0006536)4.01917225
21Chronic obstructive pulmonary disease (HP:0006510)4.01917225
22Abnormality of liposaccharide metabolism (HP:0010968)3.70548205
23Abnormality of glycosphingolipid metabolism (HP:0004343)3.70548205
24Abnormality of glycolipid metabolism (HP:0010969)3.70548205
25Axonal loss (HP:0003447)3.68431748
26Recurrent fungal infections (HP:0002841)3.66838618
27Vasculitis (HP:0002633)3.54482723
28Mutism (HP:0002300)3.45799892
29Disinhibition (HP:0000734)3.29462003
30Dysostosis multiplex (HP:0000943)3.27183907
31Glomerulonephritis (HP:0000099)3.16416089
32Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.11760485
33Urticaria (HP:0001025)3.05914509
34Basal ganglia calcification (HP:0002135)3.05259519
35Tetraparesis (HP:0002273)3.04168374
36Neurofibrillary tangles (HP:0002185)3.03388095
37Thick nail (HP:0001805)3.00698108
38Increased IgM level (HP:0003496)2.99694136
39Interstitial pulmonary disease (HP:0006530)2.97242821
40Cellulitis (HP:0100658)2.95309674
41Prostate neoplasm (HP:0100787)2.94491798
42Recurrent viral infections (HP:0004429)2.93399401
43Myocardial infarction (HP:0001658)2.91881404
44Purpura (HP:0000979)2.88081797
45Pulmonary infiltrates (HP:0002113)2.80752579
46Periodontitis (HP:0000704)2.76011707
47Chronic mucocutaneous candidiasis (HP:0002728)2.71289611
48Recurrent cutaneous fungal infections (HP:0011370)2.71289611
49Chronic otitis media (HP:0000389)2.71120811
50Mucopolysacchariduria (HP:0008155)2.68340923
51Urinary glycosaminoglycan excretion (HP:0003541)2.68340923
52Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.67225209
53Osteomyelitis (HP:0002754)2.64737918
54Leukocytosis (HP:0001974)2.61443181
55Increased serum ferritin (HP:0003281)2.61143122
56Pustule (HP:0200039)2.60058980
57Hepatosplenomegaly (HP:0001433)2.59642129
58Abnormality of polysaccharide metabolism (HP:0011012)2.59100711
59Abnormality of glycosaminoglycan metabolism (HP:0004371)2.59100711
60Abnormality of mucopolysaccharide metabolism (HP:0011020)2.59100711
61Meningitis (HP:0001287)2.58713880
62Nuclear cataract (HP:0100018)2.58652866
63Loss of speech (HP:0002371)2.55984566
64Recurrent pneumonia (HP:0006532)2.53964951
65Apathy (HP:0000741)2.53557785
66Diminished motivation (HP:0000745)2.52016274
67Neuronal loss in central nervous system (HP:0002529)2.51344934
68Agnosia (HP:0010524)2.48547746
69Arterial thrombosis (HP:0004420)2.46010302
70Hematochezia (HP:0002573)2.40312006
71Amyloidosis (HP:0011034)2.39777359
72Bone pain (HP:0002653)2.36364594
73Keratoconjunctivitis sicca (HP:0001097)2.36215000
74Progressive neurologic deterioration (HP:0002344)2.32956292
75Inappropriate behavior (HP:0000719)2.30026645
76Premature loss of primary teeth (HP:0006323)2.28096735
77Hemoptysis (HP:0002105)2.26532619
78Gastrointestinal infarctions (HP:0005244)2.26224571
79Hypergammaglobulinemia (HP:0010702)2.22341758
80Nephritis (HP:0000123)2.22333158
81Complement deficiency (HP:0004431)2.21236472
82Keratoconjunctivitis (HP:0001096)2.18171134
83Encephalitis (HP:0002383)2.18010461
84Cerebral inclusion bodies (HP:0100314)2.17016173
85Vertebral compression fractures (HP:0002953)2.16350738
86Gingival bleeding (HP:0000225)2.15065784
87Recurrent lower respiratory tract infections (HP:0002783)2.15063770
88Restrictive lung disease (HP:0002091)2.13868495
89Pathologic fracture (HP:0002756)2.10131848
90Malnutrition (HP:0004395)2.09611072
91Abnormality of iron homeostasis (HP:0011031)2.09350290
92T lymphocytopenia (HP:0005403)2.09267093
93Increased IgE level (HP:0003212)2.09114158
94Personality changes (HP:0000751)2.08582077
95Polyneuropathy (HP:0001271)2.06677296
96Metaphyseal irregularity (HP:0003025)2.03674594
97Joint hemorrhage (HP:0005261)2.03574103
98Asymmetric septal hypertrophy (HP:0001670)2.02567106
99Anorexia (HP:0002039)1.98634222
100Abnormality of complement system (HP:0005339)1.97150359
101Osteolytic defects of the phalanges of the hand (HP:0009771)1.96961835
102Osteolytic defects of the hand bones (HP:0009699)1.96961835
103Dementia (HP:0000726)1.96876547
104J-shaped sella turcica (HP:0002680)1.94874849
105Nasal polyposis (HP:0100582)1.93992874
106Eosinophilia (HP:0001880)1.93561245
107Arthralgia (HP:0002829)1.92552370
108Colitis (HP:0002583)1.91983417
109Progressive visual loss (HP:0000529)1.91845557
110Porencephaly (HP:0002132)1.91437837
111Abnormality of T cell number (HP:0011839)1.90079686
112Pulmonary embolism (HP:0002204)1.90066564
113Peripheral demyelination (HP:0011096)1.89908084
114Gangrene (HP:0100758)1.89476741
115Poor head control (HP:0002421)1.88027576
116Upper motor neuron abnormality (HP:0002127)1.87598490
117Spontaneous hematomas (HP:0007420)1.86105630
118Albinism (HP:0001022)1.85979424
119Memory impairment (HP:0002354)1.84752256
120Abnormality of the vasculature of the conjunctiva (HP:0008054)1.84229773
121Prolonged neonatal jaundice (HP:0006579)1.83516989
122Petechiae (HP:0000967)1.83193545
123Inflammation of the large intestine (HP:0002037)1.82833674
124Abnormality of the pericardium (HP:0001697)1.81250915
125Esophageal neoplasm (HP:0100751)1.80825337
126Neoplasm of head and neck (HP:0012288)1.80825337
127Nausea (HP:0002018)1.79892000
128Sepsis (HP:0100806)1.78775956
129Abnormality of the nasal mucosa (HP:0000433)1.78661553
130Gastrointestinal stroma tumor (HP:0100723)1.78529299

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.49784910
2MAP3K144.43514735
3TBK13.92542053
4IRAK33.84198012
5BLK3.57273937
6PBK3.41323514
7TYK23.15850292
8IRAK43.11084565
9MAP4K12.87828177
10IKBKE2.70388078
11IKBKB2.55676519
12PRPF4B2.34752341
13KIT2.23324511
14JAK32.12834899
15ERN12.04360622
16FGR2.00607804
17TAOK11.93181542
18JAK11.91698205
19MAP3K131.90913215
20TXK1.89014367
21DDR21.83854798
22CSK1.71182284
23PIM21.65398449
24CHUK1.57034503
25FES1.49087926
26CDC42BPA1.48234737
27CSF1R1.43208134
28SYK1.40678913
29EPHB11.40052597
30HCK1.39650069
31TGFBR21.33009570
32TAOK31.28506820
33ZAP701.24848873
34ABL21.22682524
35LYN1.18486430
36ACVR1B1.16046564
37JAK21.14582896
38MATK1.12494966
39RPS6KA41.10526358
40TNK21.08889544
41LCK1.07947721
42MARK31.06909536
43NEK91.06379628
44SIK21.03798809
45BMX1.01025600
46TESK20.94490742
47NME20.93610345
48BMPR20.90944073
49CAMKK20.90544378
50MAP3K100.89717751
51ARAF0.89335906
52PIM10.86623862
53BTK0.86552476
54SIK30.81559737
55GRK70.78352078
56EGFR0.77047641
57STK100.76933489
58IRAK10.74659038
59MAP3K110.72736211
60MAP3K50.71653706
61YES10.71438622
62ADRBK20.70471572
63ABL10.70035549
64EPHA30.66755652
65CLK10.66698858
66EIF2AK20.65645534
67PTK60.64875799
68STK40.64838645
69PRKCD0.64310726
70RPS6KL10.59357836
71RPS6KC10.59357836
72MAPK70.59036483
73KSR20.57408383
74MOS0.57262663
75IRAK20.56951913
76MARK20.56749641
77MAP3K10.55114721
78MST40.54915717
79FGFR40.54292382
80GRK60.54018544
81TRIB30.52426384
82MAPK120.51728308
83TEC0.50347890
84FGFR30.49861098
85MAP2K30.49470405
86DAPK30.49313350
87SIK10.48553872
88RPS6KA20.48420906
89MST1R0.48062332
90CAMK1D0.47726155
91TTN0.47637430
92PRKD20.46856367
93MAP2K60.46789048
94FYN0.46381291
95DAPK20.43457257
96TESK10.43445916
97TYRO30.41102721
98PRKCQ0.41043321
99LRRK20.40728257
100MAPKAPK20.40552632
101PAK40.40269862
102ALK0.36688336
103ERBB40.36002430
104MAP3K30.34773443
105PDPK10.34620663
106HIPK20.33215575
107SMG10.32961666
108MAP3K60.32571058
109PRKG20.32130524
110MAP3K80.29943657
111MAPK40.29897117
112PKN10.29446920
113RIPK10.29429290
114ITK0.29292953
115RPS6KA60.28116198
116CDK60.27035276
117INSR0.26332548
118PLK20.25880274
119PKN20.25866110
120PDK10.25293987
121STK30.24966861
122TRPM70.23209211
123SRC0.22275815
124PDGFRB0.22138020
125TAOK20.22097482
126IGF1R0.20133284

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.51612924
2Staphylococcus aureus infection_Homo sapiens_hsa051503.02363518
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.89809558
4Graft-versus-host disease_Homo sapiens_hsa053322.86997848
5Osteoclast differentiation_Homo sapiens_hsa043802.67393989
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.56302916
7Legionellosis_Homo sapiens_hsa051342.49506009
8Pertussis_Homo sapiens_hsa051332.40226131
9Malaria_Homo sapiens_hsa051442.39411156
10NOD-like receptor signaling pathway_Homo sapiens_hsa046212.39373697
11Tuberculosis_Homo sapiens_hsa051522.39242065
12Rheumatoid arthritis_Homo sapiens_hsa053232.30029924
13Allograft rejection_Homo sapiens_hsa053302.28179738
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.20070280
15Lysosome_Homo sapiens_hsa041422.12922682
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.07802851
17TNF signaling pathway_Homo sapiens_hsa046682.02052431
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.98615626
19Measles_Homo sapiens_hsa051621.97268624
20Asthma_Homo sapiens_hsa053101.92106034
21Influenza A_Homo sapiens_hsa051641.87525275
22B cell receptor signaling pathway_Homo sapiens_hsa046621.85378403
23Phagosome_Homo sapiens_hsa041451.82167125
24African trypanosomiasis_Homo sapiens_hsa051431.76701376
25Type I diabetes mellitus_Homo sapiens_hsa049401.73277991
26Salmonella infection_Homo sapiens_hsa051321.71281290
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.69340835
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.61217888
29Toxoplasmosis_Homo sapiens_hsa051451.56205750
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.50273746
31Hematopoietic cell lineage_Homo sapiens_hsa046401.43540655
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.43500297
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.39400962
34Other glycan degradation_Homo sapiens_hsa005111.37229982
35Herpes simplex infection_Homo sapiens_hsa051681.36483398
36Chemokine signaling pathway_Homo sapiens_hsa040621.36021770
37Shigellosis_Homo sapiens_hsa051311.34476491
38Apoptosis_Homo sapiens_hsa042101.32755915
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.27124900
40Antigen processing and presentation_Homo sapiens_hsa046121.25063642
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.20650474
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.12519320
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10724598
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08873228
45Hepatitis C_Homo sapiens_hsa051601.05760659
46Hepatitis B_Homo sapiens_hsa051611.05407780
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01219675
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98191363
49Amoebiasis_Homo sapiens_hsa051460.93758380
50Collecting duct acid secretion_Homo sapiens_hsa049660.91357344
51Autoimmune thyroid disease_Homo sapiens_hsa053200.88046790
52Viral myocarditis_Homo sapiens_hsa054160.87964968
53T cell receptor signaling pathway_Homo sapiens_hsa046600.85077245
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.83122038
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82801272
56Prion diseases_Homo sapiens_hsa050200.81529971
57Acute myeloid leukemia_Homo sapiens_hsa052210.80822216
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72734064
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.71363848
60Type II diabetes mellitus_Homo sapiens_hsa049300.70211511
61Bladder cancer_Homo sapiens_hsa052190.69886533
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.68453839
63Primary immunodeficiency_Homo sapiens_hsa053400.67114445
64Chronic myeloid leukemia_Homo sapiens_hsa052200.67083892
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67028500
66Complement and coagulation cascades_Homo sapiens_hsa046100.65442648
67Prolactin signaling pathway_Homo sapiens_hsa049170.65276046
68Pancreatic cancer_Homo sapiens_hsa052120.65244895
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65043997
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57630359
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.56628502
72Systemic lupus erythematosus_Homo sapiens_hsa053220.55576870
73Epstein-Barr virus infection_Homo sapiens_hsa051690.54071561
74Galactose metabolism_Homo sapiens_hsa000520.52227328
75HIF-1 signaling pathway_Homo sapiens_hsa040660.51563711
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51402637
77Mineral absorption_Homo sapiens_hsa049780.50062953
78Platelet activation_Homo sapiens_hsa046110.49838487
79VEGF signaling pathway_Homo sapiens_hsa043700.48458706
80PPAR signaling pathway_Homo sapiens_hsa033200.39023568
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38105598
82Dorso-ventral axis formation_Homo sapiens_hsa043200.34506531
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34367575
84Small cell lung cancer_Homo sapiens_hsa052220.34009384
85Sphingolipid metabolism_Homo sapiens_hsa006000.33886980
86Endocytosis_Homo sapiens_hsa041440.33806465
87Viral carcinogenesis_Homo sapiens_hsa052030.33065495
88Fructose and mannose metabolism_Homo sapiens_hsa000510.30859285
89Renal cell carcinoma_Homo sapiens_hsa052110.30792399
90Caffeine metabolism_Homo sapiens_hsa002320.30654491
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29709692
92GnRH signaling pathway_Homo sapiens_hsa049120.29447809
93Vibrio cholerae infection_Homo sapiens_hsa051100.27642573
94Notch signaling pathway_Homo sapiens_hsa043300.26133027
95Insulin resistance_Homo sapiens_hsa049310.25998221
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25919264
97Proteoglycans in cancer_Homo sapiens_hsa052050.25795893
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.23838670
99Non-small cell lung cancer_Homo sapiens_hsa052230.22155276
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21449631
101MAPK signaling pathway_Homo sapiens_hsa040100.20694596
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18386843
103HTLV-I infection_Homo sapiens_hsa051660.18068839
104Renin-angiotensin system_Homo sapiens_hsa046140.17385567
105FoxO signaling pathway_Homo sapiens_hsa040680.17231109
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.15893305
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.15372141
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.15119248
109MicroRNAs in cancer_Homo sapiens_hsa052060.13010721
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.11990287
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.08574973

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