SLC15A5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.30322345
2L-phenylalanine catabolic process (GO:0006559)6.30322345
3aromatic amino acid family catabolic process (GO:0009074)6.18364180
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.08215158
5L-phenylalanine metabolic process (GO:0006558)6.08215158
6indole-containing compound catabolic process (GO:0042436)6.08128447
7indolalkylamine catabolic process (GO:0046218)6.08128447
8tryptophan catabolic process (GO:0006569)6.08128447
9tryptophan metabolic process (GO:0006568)5.66389694
10bile acid biosynthetic process (GO:0006699)5.45582529
11kynurenine metabolic process (GO:0070189)5.42560361
12urea cycle (GO:0000050)5.42084404
13urea metabolic process (GO:0019627)5.42084404
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.21905429
15nitrogen cycle metabolic process (GO:0071941)4.93817238
16cysteine metabolic process (GO:0006534)4.92249123
17sulfur amino acid catabolic process (GO:0000098)4.79886669
18alpha-linolenic acid metabolic process (GO:0036109)4.77146319
19coenzyme catabolic process (GO:0009109)4.67333782
20complement activation, alternative pathway (GO:0006957)4.65811436
21cellular ketone body metabolic process (GO:0046950)4.62959745
22glyoxylate metabolic process (GO:0046487)4.62819082
23regulation of protein activation cascade (GO:2000257)4.61698793
24cellular glucuronidation (GO:0052695)4.57736815
25homocysteine metabolic process (GO:0050667)4.52014201
26bile acid metabolic process (GO:0008206)4.50126993
27aromatic amino acid family metabolic process (GO:0009072)4.47053218
28indolalkylamine metabolic process (GO:0006586)4.37582220
29regulation of complement activation (GO:0030449)4.37526041
30serine family amino acid catabolic process (GO:0009071)4.33100779
31glucuronate metabolic process (GO:0019585)4.32751512
32uronic acid metabolic process (GO:0006063)4.32751512
33amine catabolic process (GO:0009310)4.32260685
34cellular biogenic amine catabolic process (GO:0042402)4.32260685
35high-density lipoprotein particle remodeling (GO:0034375)4.28005117
36regulation of female gonad development (GO:2000194)4.26310550
37fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.25928321
38regulation of triglyceride catabolic process (GO:0010896)4.17997619
39peptidyl-glutamic acid carboxylation (GO:0017187)4.15191458
40protein carboxylation (GO:0018214)4.15191458
41tyrosine metabolic process (GO:0006570)4.07590587
42bile acid and bile salt transport (GO:0015721)4.01878306
43drug catabolic process (GO:0042737)3.98909453
44amino-acid betaine metabolic process (GO:0006577)3.96017964
45ketone body metabolic process (GO:1902224)3.95851711
46ethanol oxidation (GO:0006069)3.95787240
47alpha-amino acid catabolic process (GO:1901606)3.94150064
48nicotinamide nucleotide biosynthetic process (GO:0019359)3.94114163
49pyridine nucleotide biosynthetic process (GO:0019363)3.94114163
50lysine metabolic process (GO:0006553)3.92696447
51lysine catabolic process (GO:0006554)3.92696447
52imidazole-containing compound metabolic process (GO:0052803)3.91673492
53triglyceride homeostasis (GO:0070328)3.91505473
54acylglycerol homeostasis (GO:0055090)3.91505473
55negative regulation of fibrinolysis (GO:0051918)3.89306886
56NAD biosynthetic process (GO:0009435)3.84779166
57regulation of fibrinolysis (GO:0051917)3.81815111
58aldehyde catabolic process (GO:0046185)3.81118168
59regulation of cholesterol esterification (GO:0010872)3.72297446
60fat-soluble vitamin biosynthetic process (GO:0042362)3.71887190
61arginine metabolic process (GO:0006525)3.71071917
62plasma lipoprotein particle remodeling (GO:0034369)3.66244550
63protein-lipid complex remodeling (GO:0034368)3.66244550
64macromolecular complex remodeling (GO:0034367)3.66244550
65peroxisome fission (GO:0016559)3.64684168
66reverse cholesterol transport (GO:0043691)3.63969852
67complement activation, classical pathway (GO:0006958)3.63582555
68cellular amino acid catabolic process (GO:0009063)3.60027738
69cofactor catabolic process (GO:0051187)3.59787075
70fibrinolysis (GO:0042730)3.58498640
71cellular modified amino acid catabolic process (GO:0042219)3.58404565
72phospholipid efflux (GO:0033700)3.58220685
73benzene-containing compound metabolic process (GO:0042537)3.55118931
74piRNA metabolic process (GO:0034587)3.49385583
75negative regulation of execution phase of apoptosis (GO:1900118)3.45602030
76serine family amino acid metabolic process (GO:0009069)3.44101908
77linoleic acid metabolic process (GO:0043651)3.43934830
78negative regulation of lipase activity (GO:0060192)3.41657812
79complement activation (GO:0006956)3.37797429
80acetyl-CoA metabolic process (GO:0006084)3.35708528
81exogenous drug catabolic process (GO:0042738)3.31862586
82citrulline biosynthetic process (GO:0019240)3.31698648
83regulation of sequestering of triglyceride (GO:0010889)3.29890496
84low-density lipoprotein particle remodeling (GO:0034374)3.27079626
85opsonization (GO:0008228)3.26706971
86dicarboxylic acid biosynthetic process (GO:0043650)3.26302972
87glutamate metabolic process (GO:0006536)3.26269328
88glycine metabolic process (GO:0006544)3.26048940
89cytolysis (GO:0019835)3.25237126
90protein activation cascade (GO:0072376)3.20565602
91cholesterol efflux (GO:0033344)3.20085686
92carboxylic acid catabolic process (GO:0046395)3.19539601
93organic acid catabolic process (GO:0016054)3.19539601
94regulation of bile acid biosynthetic process (GO:0070857)3.17051463
95very-low-density lipoprotein particle assembly (GO:0034379)3.13700725
96NAD metabolic process (GO:0019674)3.13224895
97sulfur amino acid metabolic process (GO:0000096)3.12585831
98negative regulation of sterol transport (GO:0032372)3.09282637
99negative regulation of cholesterol transport (GO:0032375)3.09282637
100response to nitrosative stress (GO:0051409)3.07790730

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.56334631
2EGR1_23403033_ChIP-Seq_LIVER_Mouse5.54391265
3* RXR_22158963_ChIP-Seq_LIVER_Mouse5.24190511
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.15061000
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.13662270
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.66333181
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.97017013
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.86814365
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.70684119
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.54803468
11KAP1_22055183_ChIP-Seq_ESCs_Mouse2.26075498
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.23372901
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.08695395
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.04276624
15GBX2_23144817_ChIP-Seq_PC3_Human1.91967502
16FLI1_27457419_Chip-Seq_LIVER_Mouse1.75997087
17SUZ12_27294783_Chip-Seq_NPCs_Mouse1.68611961
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65493333
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64989431
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63814141
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.59607102
22NFE2_27457419_Chip-Seq_LIVER_Mouse1.57674715
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56174533
24HTT_18923047_ChIP-ChIP_STHdh_Human1.55745489
25EZH2_27294783_Chip-Seq_NPCs_Mouse1.47470044
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47336846
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46531507
28AUTS2_25519132_ChIP-Seq_293T-REX_Human1.40556601
29STAT1_17558387_ChIP-Seq_HELA_Human1.37939701
30* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35328944
31P300_19829295_ChIP-Seq_ESCs_Human1.34706120
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32864452
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30140250
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29828598
35ESR1_20079471_ChIP-ChIP_T-47D_Human1.27562493
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25429797
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24664202
38CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18190703
39TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17956511
40EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17687207
41CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16717012
42NANOG_18555785_Chip-Seq_ESCs_Mouse1.15658461
43AR_21572438_ChIP-Seq_LNCaP_Human1.14349663
44MYC_18940864_ChIP-ChIP_HL60_Human1.14333371
45STAT3_18555785_Chip-Seq_ESCs_Mouse1.13119993
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.12494792
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10831886
48EWS_26573619_Chip-Seq_HEK293_Human1.10520226
49TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.10170881
50CRX_20693478_ChIP-Seq_RETINA_Mouse1.09631168
51OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08875613
52P53_22387025_ChIP-Seq_ESCs_Mouse1.07902280
53SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07586257
54SMAD4_21799915_ChIP-Seq_A2780_Human1.05951968
55EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05146181
56FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03915512
57SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03499924
58FUS_26573619_Chip-Seq_HEK293_Human1.02702657
59CDX2_22108803_ChIP-Seq_LS180_Human1.02523235
60STAT3_23295773_ChIP-Seq_U87_Human1.01990362
61ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01909643
62JUN_21703547_ChIP-Seq_K562_Human1.01833273
63RUNX1_27457419_Chip-Seq_LIVER_Mouse1.01715713
64E2F1_18555785_Chip-Seq_ESCs_Mouse1.01227983
65OCT4_18555785_Chip-Seq_ESCs_Mouse1.01139570
66AR_25329375_ChIP-Seq_VCAP_Human1.00649229
67HNF4A_19822575_ChIP-Seq_HepG2_Human1.00174800
68SOX2_18555785_Chip-Seq_ESCs_Mouse0.99690330
69CMYC_18555785_Chip-Seq_ESCs_Mouse0.98705972
70ESRRB_18555785_Chip-Seq_ESCs_Mouse0.98648750
71TAF15_26573619_Chip-Seq_HEK293_Human0.98331391
72FOXA2_19822575_ChIP-Seq_HepG2_Human0.98032183
73NMYC_18555785_Chip-Seq_ESCs_Mouse0.97665070
74SMAD1_18555785_Chip-Seq_ESCs_Mouse0.96417748
75TAL1_26923725_Chip-Seq_HPCs_Mouse0.95809072
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95697470
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95244702
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95244702
79FOXH1_21741376_ChIP-Seq_EPCs_Human0.95210776
80CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94758947
81MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92617379
82PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90514206
83STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90350826
84ZFX_18555785_Chip-Seq_ESCs_Mouse0.89995111
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89815243
86P300_18555785_Chip-Seq_ESCs_Mouse0.89081420
87BCAT_22108803_ChIP-Seq_LS180_Human0.88908009
88CTCF_18555785_Chip-Seq_ESCs_Mouse0.88457597
89NFYA_21822215_ChIP-Seq_K562_Human0.88074414
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87912215
91ERG_20517297_ChIP-Seq_VCAP_Human0.87591195
92GF1B_26923725_Chip-Seq_HPCs_Mouse0.85872504
93KLF4_18555785_Chip-Seq_ESCs_Mouse0.84435322
94TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84416998
95CBP_20019798_ChIP-Seq_JUKART_Human0.84374340
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.84374340
97CTBP1_25329375_ChIP-Seq_LNCAP_Human0.83604005
98Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.83140258
99LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82732432
100CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.82706905

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.92852767
2MP0005360_urolithiasis6.68203323
3MP0005365_abnormal_bile_salt5.60558800
4MP0005085_abnormal_gallbladder_physiolo5.56691378
5MP0008875_abnormal_xenobiotic_pharmacok4.65623460
6MP0005451_abnormal_body_composition3.80356151
7MP0003806_abnormal_nucleotide_metabolis3.48751558
8MP0003718_maternal_effect3.45186939
9MP0003252_abnormal_bile_duct3.34194822
10MP0003646_muscle_fatigue3.17390277
11MP0010329_abnormal_lipoprotein_level2.78627215
12MP0005332_abnormal_amino_acid2.42087841
13MP0009697_abnormal_copulation2.29117337
14MP0009840_abnormal_foam_cell2.19066620
15MP0003195_calcinosis2.10661068
16MP0001984_abnormal_olfaction1.97990863
17MP0001666_abnormal_nutrient_absorption1.91066762
18MP0003868_abnormal_feces_composition1.72882975
19MP0005647_abnormal_sex_gland1.68502106
20MP0000609_abnormal_liver_physiology1.62456966
21MP0002118_abnormal_lipid_homeostasis1.62291506
22MP0005083_abnormal_biliary_tract1.56928763
23MP0005395_other_phenotype1.50166341
24MP0002138_abnormal_hepatobiliary_system1.47397171
25MP0003699_abnormal_female_reproductive1.41270018
26MP0000566_synostosis1.41065538
27MP0001119_abnormal_female_reproductive1.40103497
28MP0002638_abnormal_pupillary_reflex1.37742764
29MP0005646_abnormal_pituitary_gland1.34122902
30MP0002876_abnormal_thyroid_physiology1.31411660
31MP0009764_decreased_sensitivity_to1.31292430
32MP0005319_abnormal_enzyme/_coenzyme1.30646126
33MP0001529_abnormal_vocalization1.29981604
34MP0003186_abnormal_redox_activity1.27485850
35MP0004019_abnormal_vitamin_homeostasis1.26520474
36MP0006292_abnormal_olfactory_placode1.24689823
37MP0005408_hypopigmentation1.21400178
38MP0001764_abnormal_homeostasis1.19780488
39MP0002837_dystrophic_cardiac_calcinosis1.12612490
40MP0006036_abnormal_mitochondrial_physio1.11482352
41MP0005584_abnormal_enzyme/coenzyme_acti1.10749498
42MP0000579_abnormal_nail_morphology1.08481652
43MP0003656_abnormal_erythrocyte_physiolo1.04319431
44MP0010368_abnormal_lymphatic_system1.03118691
45MP0005187_abnormal_penis_morphology1.03103024
46MP0005220_abnormal_exocrine_pancreas0.93025029
47MP0002971_abnormal_brown_adipose0.90162281
48MP0000639_abnormal_adrenal_gland0.90114339
49MP0002249_abnormal_larynx_morphology0.89825638
50MP0004782_abnormal_surfactant_physiolog0.89023611
51MP0005266_abnormal_metabolism0.81238620
52MP0000598_abnormal_liver_morphology0.80284208
53MP0004130_abnormal_muscle_cell0.78852342
54MP0005084_abnormal_gallbladder_morpholo0.76505775
55MP0004142_abnormal_muscle_tone0.76332077
56MP0000653_abnormal_sex_gland0.73976798
57MP0005535_abnormal_body_temperature0.72731278
58MP0001929_abnormal_gametogenesis0.71882584
59MP0001905_abnormal_dopamine_level0.71100649
60MP0001919_abnormal_reproductive_system0.70845143
61MP0009763_increased_sensitivity_to0.70265096
62MP0002078_abnormal_glucose_homeostasis0.69515992
63MP0003191_abnormal_cellular_cholesterol0.67843053
64MP0005334_abnormal_fat_pad0.66858217
65MP0002210_abnormal_sex_determination0.63349398
66MP0009642_abnormal_blood_homeostasis0.63015032
67MP0001502_abnormal_circadian_rhythm0.62942515
68MP0009643_abnormal_urine_homeostasis0.61634942
69MP0006035_abnormal_mitochondrial_morpho0.60570499
70MP0009765_abnormal_xenobiotic_induced0.59684991
71MP0005389_reproductive_system_phenotype0.59232713
72MP0005376_homeostasis/metabolism_phenot0.58764932
73MP0002102_abnormal_ear_morphology0.57930357
74MP0006276_abnormal_autonomic_nervous0.57168676
75MP0003890_abnormal_embryonic-extraembry0.57136951
76MP0005636_abnormal_mineral_homeostasis0.56745386
77MP0008874_decreased_physiological_sensi0.55102538
78MP0000613_abnormal_salivary_gland0.53904663
79MP0002161_abnormal_fertility/fecundity0.53175984
80MP0002736_abnormal_nociception_after0.52097320
81MP0005248_abnormal_Harderian_gland0.52075456
82MP0002332_abnormal_exercise_endurance0.51972068
83MP0008469_abnormal_protein_level0.51525925
84MP0000372_irregular_coat_pigmentation0.48901835
85MP0005166_decreased_susceptibility_to0.46041406
86MP0003937_abnormal_limbs/digits/tail_de0.45533123
87MP0004185_abnormal_adipocyte_glucose0.44366215
88MP0005257_abnormal_intraocular_pressure0.43634501
89MP0010386_abnormal_urinary_bladder0.43633766
90MP0003011_delayed_dark_adaptation0.42580165
91MP0001915_intracranial_hemorrhage0.42439335
92MP0003953_abnormal_hormone_level0.42232292
93MP0008961_abnormal_basal_metabolism0.41444812
94MP0002269_muscular_atrophy0.37901624
95MP0002653_abnormal_ependyma_morphology0.37427146
96MP0005197_abnormal_uvea_morphology0.35593222
97MP0005499_abnormal_olfactory_system0.35393966
98MP0005394_taste/olfaction_phenotype0.35393966
99MP0008789_abnormal_olfactory_epithelium0.35026464
100MP0002928_abnormal_bile_duct0.35020831

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.44219217
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.20978180
3Hypobetalipoproteinemia (HP:0003563)6.16766906
4Deep venous thrombosis (HP:0002625)5.87090369
5Prolonged partial thromboplastin time (HP:0003645)4.96710049
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.60117930
7Complement deficiency (HP:0004431)4.47183537
8Xanthomatosis (HP:0000991)4.42303068
9Hyperlipoproteinemia (HP:0010980)4.23871009
10Hyperglycinemia (HP:0002154)4.10869129
11Hypolipoproteinemia (HP:0010981)4.06837143
12Hyperglycinuria (HP:0003108)3.73689608
13Abnormality of methionine metabolism (HP:0010901)3.72110617
14Fat malabsorption (HP:0002630)3.71512813
15Ketosis (HP:0001946)3.69321446
16Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.67079637
17Hyperammonemia (HP:0001987)3.65347480
18Conjugated hyperbilirubinemia (HP:0002908)3.64699121
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.62071118
20Abnormality of aspartate family amino acid metabolism (HP:0010899)3.60577334
21Epidermoid cyst (HP:0200040)3.48947679
22Abnormality of glycine metabolism (HP:0010895)3.46334776
23Abnormality of serine family amino acid metabolism (HP:0010894)3.46334776
24Joint hemorrhage (HP:0005261)3.39997177
25Abnormality of pyrimidine metabolism (HP:0004353)3.34195080
26Abnormality of sulfur amino acid metabolism (HP:0004339)3.34044383
27Male infertility (HP:0003251)3.33496447
28Abnormality of glutamine family amino acid metabolism (HP:0010902)3.32390957
29Abnormality of serum amino acid levels (HP:0003112)3.19013918
30Acanthocytosis (HP:0001927)3.15821779
31Abnormality of fatty-acid metabolism (HP:0004359)3.14786115
32Renal cortical cysts (HP:0000803)3.13480560
33Ketoacidosis (HP:0001993)3.10691693
34Steatorrhea (HP:0002570)3.10666759
35Abnormality of the intrinsic pathway (HP:0010989)3.09352398
36Spontaneous abortion (HP:0005268)3.06004214
37Hypoglycemic coma (HP:0001325)3.03998625
38Cholecystitis (HP:0001082)3.03420021
39Abnormal gallbladder physiology (HP:0012438)3.03420021
40Abnormality of complement system (HP:0005339)3.01130829
41Abnormality of the common coagulation pathway (HP:0010990)2.96547548
42Hypoalphalipoproteinemia (HP:0003233)2.88860822
43Hypercholesterolemia (HP:0003124)2.74535956
44Generalized aminoaciduria (HP:0002909)2.74501195
45Abnormality of nucleobase metabolism (HP:0010932)2.68083800
46Papillary thyroid carcinoma (HP:0002895)2.61221634
47Hyperbilirubinemia (HP:0002904)2.61146886
48Brushfield spots (HP:0001088)2.53143339
49Bile duct proliferation (HP:0001408)2.48319467
50Abnormal biliary tract physiology (HP:0012439)2.48319467
51Metabolic acidosis (HP:0001942)2.48105558
52Recurrent gram-negative bacterial infections (HP:0005420)2.45918792
53Lethargy (HP:0001254)2.43687872
54Hepatocellular carcinoma (HP:0001402)2.42196491
55Cortical dysplasia (HP:0002539)2.38666388
56Enlarged kidneys (HP:0000105)2.36120268
57Abnormality of purine metabolism (HP:0004352)2.35028160
58Dicarboxylic aciduria (HP:0003215)2.34126130
59Abnormality of dicarboxylic acid metabolism (HP:0010995)2.34126130
60Abnormal gallbladder morphology (HP:0012437)2.33598415
61Hypoglycemic seizures (HP:0002173)2.29050011
62Fair hair (HP:0002286)2.26999716
63Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.20648620
64Proximal tubulopathy (HP:0000114)2.19053765
65Cholelithiasis (HP:0001081)2.14533303
66Delayed CNS myelination (HP:0002188)2.03973384
67Hydroxyprolinuria (HP:0003080)2.03649550
68Abnormality of proline metabolism (HP:0010907)2.03649550
69Irritability (HP:0000737)2.02517773
70Malnutrition (HP:0004395)2.00865434
71Abnormality of the gallbladder (HP:0005264)2.00180596
72Cerebral edema (HP:0002181)2.00052266
73Hyperglycemia (HP:0003074)1.99847741
74Hypochromic microcytic anemia (HP:0004840)1.97978601
75Gout (HP:0001997)1.94950587
76Late onset (HP:0003584)1.94911455
77Opisthotonus (HP:0002179)1.94892193
78Hypergonadotropic hypogonadism (HP:0000815)1.94323769
79Systemic lupus erythematosus (HP:0002725)1.94030891
80Sensorimotor neuropathy (HP:0007141)1.92930140
81Azoospermia (HP:0000027)1.92408036
82Myocardial infarction (HP:0001658)1.89533279
83Poikilocytosis (HP:0004447)1.88752823
84Chromosomal breakage induced by crosslinking agents (HP:0003221)1.88238359
85Abnormality of urine glucose concentration (HP:0011016)1.85794181
86Glycosuria (HP:0003076)1.85794181
87Progressive external ophthalmoplegia (HP:0000590)1.85164344
88Abnormal tarsal ossification (HP:0008369)1.78194188
89Adrenal hypoplasia (HP:0000835)1.76327895
90Increased purine levels (HP:0004368)1.76188773
91Hyperuricemia (HP:0002149)1.76188773
92Respiratory distress (HP:0002098)1.75853489
93Skin nodule (HP:0200036)1.74518903
94Chorioretinal atrophy (HP:0000533)1.72528744
95Acute hepatic failure (HP:0006554)1.71880358
96Abnormality of the renal cortex (HP:0011035)1.71404281
97Hepatic necrosis (HP:0002605)1.70914498
98Methylmalonic aciduria (HP:0012120)1.70644836
99Hyperventilation (HP:0002883)1.69700745
100Vomiting (HP:0002013)1.69437251

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K64.56045719
2STK38L4.31117718
3ERBB44.00659221
4TAOK33.95672605
5LATS23.25283692
6LATS13.16797658
7BRAF3.06912830
8MAP3K132.89209637
9MAP2K72.48409190
10BMPR22.34802431
11BCKDK2.32717380
12CDK82.25521726
13MAP2K42.25114912
14MOS2.12528214
15ARAF1.93834847
16AKT31.93356221
17MAP3K91.84357368
18SGK21.73545321
19PLK41.66270071
20MAP3K41.63056688
21MAP3K51.62833539
22DYRK21.61234080
23KSR21.49350599
24MAPK131.47097220
25MUSK1.46344886
26MELK1.41710247
27MAP3K121.38621130
28PIK3CG1.35784394
29ABL21.34622952
30CSNK1G11.31844865
31TTK1.21644150
32PINK11.21496285
33INSRR1.18250773
34SGK2231.16967058
35SGK4941.16967058
36CSNK1A1L1.15096768
37CSNK1G21.03196437
38MAPK111.02914732
39STK241.02323167
40CSNK1G31.01895968
41NLK0.99706703
42PRKAA10.92590186
43SIK10.88523049
44CHEK20.87165986
45OBSCN0.86963832
46STK30.86846563
47SGK30.86842485
48TAOK10.84608040
49RAF10.83383332
50CDK90.78999262
51PRKAA20.78988024
52NEK90.75274912
53CDK30.69148402
54CAMK2A0.65147700
55STK380.64951738
56MAP3K140.64016780
57JAK30.63946468
58KSR10.63133235
59JAK20.58848453
60PLK20.55337443
61PBK0.54859771
62BMPR1B0.54737383
63NTRK20.52585285
64FGR0.47771646
65ADRBK20.45078744
66FRK0.43560518
67CAMK2G0.43415384
68TAOK20.43125699
69ABL10.42881934
70PLK10.42204849
71FGFR40.40874005
72IRAK20.39835621
73EIF2AK10.38730997
74AKT20.36508877
75SIK30.35956813
76MST1R0.34240969
77PRKCQ0.33761867
78TYK20.33343327
79IRAK10.31924459
80PRKD30.31330680
81RET0.30538880
82PHKG10.27884730
83PHKG20.27884730
84PLK30.27526168
85PKN10.26376745
86SGK10.26167049
87PRKCZ0.26150263
88KIT0.25234446
89PDPK10.22445010
90PTK2B0.22038481
91AURKA0.22016921
92JAK10.21067944
93PDK10.20964368
94AURKB0.20619119
95HIPK20.20361419
96NUAK10.19884895
97CSNK1A10.19408692
98PRKD20.18905716
99PRKCG0.18279294
100CDK60.17464076

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.66130224
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33552202
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.32483028
4Arginine biosynthesis_Homo sapiens_hsa002202.79484283
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.69540136
6Tryptophan metabolism_Homo sapiens_hsa003802.65008291
7Complement and coagulation cascades_Homo sapiens_hsa046102.55337599
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.52957455
9Fatty acid degradation_Homo sapiens_hsa000712.45654145
10Peroxisome_Homo sapiens_hsa041462.45150632
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.42879970
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.40014530
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.37810012
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.12422202
15Propanoate metabolism_Homo sapiens_hsa006402.12292777
16Butanoate metabolism_Homo sapiens_hsa006502.06968906
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.99525935
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.98199866
19Histidine metabolism_Homo sapiens_hsa003401.97068510
20Nitrogen metabolism_Homo sapiens_hsa009101.95804633
21Fatty acid metabolism_Homo sapiens_hsa012121.89266628
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.87910009
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.78888889
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.77490940
25Chemical carcinogenesis_Homo sapiens_hsa052041.74601973
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.72724604
27beta-Alanine metabolism_Homo sapiens_hsa004101.70831224
28Folate biosynthesis_Homo sapiens_hsa007901.69044966
29PPAR signaling pathway_Homo sapiens_hsa033201.67804976
30Retinol metabolism_Homo sapiens_hsa008301.65778216
31Caffeine metabolism_Homo sapiens_hsa002321.64084426
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63212030
33Vitamin B6 metabolism_Homo sapiens_hsa007501.53124414
34Sulfur metabolism_Homo sapiens_hsa009201.49213613
35Staphylococcus aureus infection_Homo sapiens_hsa051501.47140792
36Steroid biosynthesis_Homo sapiens_hsa001001.47048248
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.46615032
38Tyrosine metabolism_Homo sapiens_hsa003501.42957291
39Pyruvate metabolism_Homo sapiens_hsa006201.40312655
40Starch and sucrose metabolism_Homo sapiens_hsa005001.40241523
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.37684785
42Phenylalanine metabolism_Homo sapiens_hsa003601.35753717
43Selenocompound metabolism_Homo sapiens_hsa004501.23524364
44Ovarian steroidogenesis_Homo sapiens_hsa049131.15947189
45Fatty acid elongation_Homo sapiens_hsa000621.15494361
46Arginine and proline metabolism_Homo sapiens_hsa003301.14466267
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12523865
48Biosynthesis of amino acids_Homo sapiens_hsa012300.98503099
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.98350182
50ABC transporters_Homo sapiens_hsa020100.97722359
51Fatty acid biosynthesis_Homo sapiens_hsa000610.96374584
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95941072
53Bile secretion_Homo sapiens_hsa049760.94263875
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87672627
55Sulfur relay system_Homo sapiens_hsa041220.84688353
56Carbon metabolism_Homo sapiens_hsa012000.83265710
57One carbon pool by folate_Homo sapiens_hsa006700.79617470
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75114705
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74551378
60Linoleic acid metabolism_Homo sapiens_hsa005910.70341068
61Metabolic pathways_Homo sapiens_hsa011000.63123273
62Lysine degradation_Homo sapiens_hsa003100.62120630
63Basal transcription factors_Homo sapiens_hsa030220.59764751
64Vitamin digestion and absorption_Homo sapiens_hsa049770.48000923
65Circadian rhythm_Homo sapiens_hsa047100.46946976
66RNA degradation_Homo sapiens_hsa030180.45874471
67Glutathione metabolism_Homo sapiens_hsa004800.42254461
68Fat digestion and absorption_Homo sapiens_hsa049750.41883404
69Glycerolipid metabolism_Homo sapiens_hsa005610.38656430
70Ether lipid metabolism_Homo sapiens_hsa005650.38190416
71Pentose phosphate pathway_Homo sapiens_hsa000300.34526851
72Homologous recombination_Homo sapiens_hsa034400.31432629
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31199075
74Prion diseases_Homo sapiens_hsa050200.31195614
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.25501908
76Fanconi anemia pathway_Homo sapiens_hsa034600.24629253
77Galactose metabolism_Homo sapiens_hsa000520.24547929
78Fructose and mannose metabolism_Homo sapiens_hsa000510.20714997
79Insulin resistance_Homo sapiens_hsa049310.17037403
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16946951
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.13519521
82Glucagon signaling pathway_Homo sapiens_hsa049220.06055149
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.06006082
84Arachidonic acid metabolism_Homo sapiens_hsa005900.04814148
85Dorso-ventral axis formation_Homo sapiens_hsa043200.03516296
86Pyrimidine metabolism_Homo sapiens_hsa002400.03510178
87Pancreatic cancer_Homo sapiens_hsa052120.02909373
88Prolactin signaling pathway_Homo sapiens_hsa049170.00601385
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.00410442
90Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0988222
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0901627
92Cyanoamino acid metabolism_Homo sapiens_hsa00460-0.0883635
93Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0789768
94TGF-beta signaling pathway_Homo sapiens_hsa04350-0.0632809
95Cell cycle_Homo sapiens_hsa04110-0.0622286
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0545858
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0511474
98Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080-0.0304571
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524-0.0246925
100Purine metabolism_Homo sapiens_hsa00230-0.0170318

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