SLC16A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of integrated proviral latency (GO:0075713)4.95521531
2chromatin remodeling at centromere (GO:0031055)4.54119076
3DNA unwinding involved in DNA replication (GO:0006268)4.41476990
4CENP-A containing nucleosome assembly (GO:0034080)4.41357106
5protein complex localization (GO:0031503)4.33181677
6mitotic metaphase plate congression (GO:0007080)4.17908141
7nuclear pore complex assembly (GO:0051292)4.16707815
8DNA replication checkpoint (GO:0000076)4.06327721
9nuclear pore organization (GO:0006999)4.03039876
10paraxial mesoderm development (GO:0048339)4.00054917
11pre-miRNA processing (GO:0031054)3.98618790
12DNA strand elongation (GO:0022616)3.97716884
13protein localization to chromosome, centromeric region (GO:0071459)3.97314894
14cellular protein complex localization (GO:0034629)3.92577985
15folic acid-containing compound biosynthetic process (GO:0009396)3.91095529
16histone exchange (GO:0043486)3.81213938
17purine nucleobase biosynthetic process (GO:0009113)3.75065969
18DNA replication-independent nucleosome organization (GO:0034724)3.74864105
19DNA replication-independent nucleosome assembly (GO:0006336)3.74864105
20lymph vessel development (GO:0001945)3.67881940
21negative regulation of chromosome segregation (GO:0051985)3.67442687
22negative regulation of mitotic sister chromatid separation (GO:2000816)3.67440906
23negative regulation of sister chromatid segregation (GO:0033046)3.67440906
24negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.67440906
25negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.67440906
26negative regulation of mitotic sister chromatid segregation (GO:0033048)3.67440906
27establishment of viral latency (GO:0019043)3.61754734
28telomere maintenance via semi-conservative replication (GO:0032201)3.58696340
29metaphase plate congression (GO:0051310)3.56053925
30negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.53410957
31vascular endothelial growth factor signaling pathway (GO:0038084)3.52904197
32mitotic sister chromatid segregation (GO:0000070)3.49969966
33regulation of helicase activity (GO:0051095)3.49188112
34DNA replication-dependent nucleosome organization (GO:0034723)3.48299984
35DNA replication-dependent nucleosome assembly (GO:0006335)3.48299984
36spindle checkpoint (GO:0031577)3.46544925
37mitotic spindle checkpoint (GO:0071174)3.40285947
38lysine catabolic process (GO:0006554)3.39826942
39lysine metabolic process (GO:0006553)3.39826942
40sarcomere organization (GO:0045214)3.38599099
41regulation of gene silencing by RNA (GO:0060966)3.37260021
42regulation of posttranscriptional gene silencing (GO:0060147)3.37260021
43regulation of gene silencing by miRNA (GO:0060964)3.37260021
44sister chromatid segregation (GO:0000819)3.35082815
45regulation of mitotic metaphase/anaphase transition (GO:0030071)3.35042021
46regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.35042021
47regulation of mitotic spindle checkpoint (GO:1903504)3.32007379
48regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.32007379
49regulation of chromosome segregation (GO:0051983)3.31779566
50regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.30955813
51regulation of translational fidelity (GO:0006450)3.29034950
52mitotic sister chromatid cohesion (GO:0007064)3.26031843
53mitotic spindle assembly checkpoint (GO:0007094)3.25784172
54regulation of sister chromatid segregation (GO:0033045)3.24353488
55regulation of mitotic sister chromatid separation (GO:0010965)3.24353488
56regulation of mitotic sister chromatid segregation (GO:0033047)3.24353488
57heart trabecula formation (GO:0060347)3.23361186
58iron ion import (GO:0097286)3.23183366
59IMP metabolic process (GO:0046040)3.23128172
60double-strand break repair via nonhomologous end joining (GO:0006303)3.22533191
61non-recombinational repair (GO:0000726)3.22533191
62aspartate family amino acid catabolic process (GO:0009068)3.22314678
63spindle assembly checkpoint (GO:0071173)3.20991120
64carnitine shuttle (GO:0006853)3.19680922
65mitotic G2/M transition checkpoint (GO:0044818)3.19325990
66heme transport (GO:0015886)3.17498121
67IMP biosynthetic process (GO:0006188)3.15251008
68tricarboxylic acid cycle (GO:0006099)3.12663377
69ATP-dependent chromatin remodeling (GO:0043044)3.11015827
70mitotic recombination (GO:0006312)3.10771722
71positive regulation of SMAD protein import into nucleus (GO:0060391)3.10252860
72telomere maintenance via recombination (GO:0000722)3.09964380
73regulation of cell fate specification (GO:0042659)3.08428574
74ribosome assembly (GO:0042255)3.07627069
75somatic hypermutation of immunoglobulin genes (GO:0016446)3.06123718
76somatic diversification of immune receptors via somatic mutation (GO:0002566)3.06123718
77DNA ligation (GO:0006266)3.04719040
78L-serine metabolic process (GO:0006563)3.01292676
79negative regulation of DNA-dependent DNA replication (GO:2000104)3.00922659
80negative regulation of mitosis (GO:0045839)3.00461186
81endothelium development (GO:0003158)2.99294645
82regulation of centriole replication (GO:0046599)2.98573175
83chromatin assembly (GO:0031497)2.96053430
84kinetochore organization (GO:0051383)2.93005008
85DNA replication initiation (GO:0006270)2.90954195
86glycine metabolic process (GO:0006544)2.88461356
87fatty acid transmembrane transport (GO:1902001)2.88207258
88chromatin assembly or disassembly (GO:0006333)2.88079815
89pentose-phosphate shunt (GO:0006098)2.87972407
90anterior/posterior axis specification, embryo (GO:0008595)2.87455793
91regulation of cardioblast differentiation (GO:0051890)2.86987423
92embryonic heart tube development (GO:0035050)2.86373171
93low-density lipoprotein particle clearance (GO:0034383)2.85771620
94retina vasculature morphogenesis in camera-type eye (GO:0061299)2.85020878
95DNA double-strand break processing (GO:0000729)2.83953169
96positive regulation of chromosome segregation (GO:0051984)2.83139284
97DNA damage response, detection of DNA damage (GO:0042769)2.82785129
98telomere maintenance via telomere lengthening (GO:0010833)2.82764887
99cardiac myofibril assembly (GO:0055003)2.82440522
100telomere maintenance via telomerase (GO:0007004)2.82341663
101notochord development (GO:0030903)2.81913784
102ventricular cardiac muscle cell development (GO:0055015)2.81883728
103serine family amino acid biosynthetic process (GO:0009070)2.81758825
104establishment of chromosome localization (GO:0051303)2.81408361
105mitotic chromosome condensation (GO:0007076)2.81034840
106mitotic nuclear envelope disassembly (GO:0007077)2.78301444
107negative regulation of fatty acid biosynthetic process (GO:0045717)2.77235026
108gap junction assembly (GO:0016264)2.75693412
109RNA-dependent DNA replication (GO:0006278)2.73657786
110pore complex assembly (GO:0046931)2.73649544
111response to X-ray (GO:0010165)2.72147559
112DNA topological change (GO:0006265)2.71906534
113embryonic process involved in female pregnancy (GO:0060136)2.71780984
114regulation of translational termination (GO:0006449)2.71315466
115negative regulation of potassium ion transmembrane transport (GO:1901380)2.71144381
116chaperone-mediated protein complex assembly (GO:0051131)2.70922731
117regulation of nuclear cell cycle DNA replication (GO:0033262)2.69654550
118ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.68784816
119heterochromatin organization (GO:0070828)2.68531847
120apoptotic process involved in morphogenesis (GO:0060561)2.68119491
121negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.67371053
122formation of translation preinitiation complex (GO:0001731)2.66325026
123protein localization to endosome (GO:0036010)2.66118071
124protein localization to kinetochore (GO:0034501)2.65582413
125embryonic foregut morphogenesis (GO:0048617)2.64957692
126nuclear envelope disassembly (GO:0051081)2.64284136
127membrane disassembly (GO:0030397)2.64284136
128establishment of apical/basal cell polarity (GO:0035089)2.59980959
129labyrinthine layer development (GO:0060711)2.59819335
130regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.58381859
131regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.58215587
132folic acid metabolic process (GO:0046655)2.58170364
133regulation of sequestering of triglyceride (GO:0010889)2.57126340
134cellular hyperosmotic response (GO:0071474)2.55482676
135cardiac muscle tissue morphogenesis (GO:0055008)2.55371653
136regulation of histone H3-K9 methylation (GO:0051570)2.55169809
137bundle of His cell to Purkinje myocyte communication (GO:0086069)2.53714479
138endoderm formation (GO:0001706)2.53056768
139patterning of blood vessels (GO:0001569)2.52872212
140pteridine-containing compound biosynthetic process (GO:0042559)2.52823693
141nucleobase biosynthetic process (GO:0046112)2.52505800
1424-hydroxyproline metabolic process (GO:0019471)2.52371364
143cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.50748176
144maternal placenta development (GO:0001893)2.49884866
145NADPH regeneration (GO:0006740)2.49384708
146fatty acid beta-oxidation (GO:0006635)2.49294026
147mRNA transcription (GO:0009299)2.48007844
148DNA strand elongation involved in DNA replication (GO:0006271)2.47453073
149cellular response to arsenic-containing substance (GO:0071243)2.46429037
150blood vessel endothelial cell migration (GO:0043534)2.46028784
151polarized epithelial cell differentiation (GO:0030859)2.44338273
152endothelial cell morphogenesis (GO:0001886)2.43748426
153protoporphyrinogen IX biosynthetic process (GO:0006782)2.43504023
154DNA duplex unwinding (GO:0032508)2.41595952
155creatine metabolic process (GO:0006600)2.41326223
156quaternary ammonium group transport (GO:0015697)2.39787940
157hippo signaling (GO:0035329)2.38864980
158negative regulation of cell fate specification (GO:0009996)2.37358302
159protoporphyrinogen IX metabolic process (GO:0046501)2.37242708
160DNA geometric change (GO:0032392)2.37208547
161cardiac muscle cell development (GO:0055013)2.35473036
162acetyl-CoA metabolic process (GO:0006084)2.34974492
163mRNA transcription from RNA polymerase II promoter (GO:0042789)2.34119319
164carnitine transmembrane transport (GO:1902603)2.33411210
165serine family amino acid metabolic process (GO:0009069)2.33028783
166vitamin transport (GO:0051180)2.33001378
167vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.32647446
168germ cell migration (GO:0008354)2.32291863
169fatty acid homeostasis (GO:0055089)2.32037854
170tetrahydrofolate metabolic process (GO:0046653)2.31119265
171thioester biosynthetic process (GO:0035384)2.30125093
172acyl-CoA biosynthetic process (GO:0071616)2.30125093

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.65437717
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.41063948
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.47380091
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.35550017
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.33812275
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.10243947
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.06470358
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.01660111
9AR_21909140_ChIP-Seq_LNCAP_Human2.90288002
10ZNF263_19887448_ChIP-Seq_K562_Human2.81864459
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.47345115
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.41874859
13HIF1A_21447827_ChIP-Seq_MCF-7_Human2.35502888
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.34132911
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.29760654
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.24781938
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.23257021
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.18137095
19* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15918803
20* CLOCK_20551151_ChIP-Seq_293T_Human2.15604079
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.10256253
22POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.09409375
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05676247
24* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.02714472
25SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.01873298
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92900912
27YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.89986181
28NANOG_16153702_ChIP-ChIP_HESCs_Human1.88451074
29POU5F1_16153702_ChIP-ChIP_HESCs_Human1.86249942
30PPARA_22158963_ChIP-Seq_LIVER_Mouse1.83596323
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.79004283
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.78979325
33SALL4_18804426_ChIP-ChIP_XEN_Mouse1.73423558
34SOX2_16153702_ChIP-ChIP_HESCs_Human1.68304115
35TTF2_22483619_ChIP-Seq_HELA_Human1.68131755
36STAT3_1855785_ChIP-Seq_MESCs_Mouse1.66517863
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.66427543
38NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.64989250
39* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.64638542
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60512688
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.59848910
42* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.59281510
43SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.59141426
44RXR_22158963_ChIP-Seq_LIVER_Mouse1.57472020
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.56092694
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.51442323
47PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51373184
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.51091524
49KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.50676254
50* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.50122501
51TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.48123369
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.47672293
53FOXP3_21729870_ChIP-Seq_TREG_Human1.46026862
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44097460
55ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.42026648
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41783482
57* LXR_22158963_ChIP-Seq_LIVER_Mouse1.41604965
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40176750
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.39918245
60* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39268425
61TCF3_18692474_ChIP-Seq_MEFs_Mouse1.39169897
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39106700
63TRIM28_21343339_ChIP-Seq_HEK293_Human1.35348513
64* XRN2_22483619_ChIP-Seq_HELA_Human1.33740691
65CREB1_15753290_ChIP-ChIP_HEK293T_Human1.33205274
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32715922
67PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.30637459
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30558185
69MYC_22102868_ChIP-Seq_BL_Human1.30257467
70ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.29382882
71PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.27299214
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26816089
73* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26605776
74EWS_26573619_Chip-Seq_HEK293_Human1.25506810
75* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.25162759
76RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25032103
77FOXO3_23340844_ChIP-Seq_DLD1_Human1.24344373
78* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24038919
79MYC_18940864_ChIP-ChIP_HL60_Human1.23326514
80* ATF3_27146783_Chip-Seq_COLON_Human1.22883832
81PPAR_26484153_Chip-Seq_NCI-H1993_Human1.22806515
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.22697430
83* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.22515028
84RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22196177
85* ELK3_25401928_ChIP-Seq_HUVEC_Human1.18389918
86VDR_23849224_ChIP-Seq_CD4+_Human1.18079250
87SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16628855
88ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16505386
89GATA1_19941826_ChIP-Seq_K562_Human1.16314410
90NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.16162430
91* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14751485
92TP63_17297297_ChIP-ChIP_HaCaT_Human1.14648454
93* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12706628
94CHD1_26751641_Chip-Seq_LNCaP_Human1.12663623
95KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.12021212
96KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.12021212
97KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.12021212
98TCF3_18692474_ChIP-Seq_MESCs_Mouse1.12006936
99SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.11274683
100EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11220579
101* GABP_19822575_ChIP-Seq_HepG2_Human1.11176475
102KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11024383
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11018336
104SOX17_20123909_ChIP-Seq_XEN_Mouse1.10110112
105FUS_26573619_Chip-Seq_HEK293_Human1.08777512
106NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08573904
107* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08483489
108CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08089154
109NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08050077
110NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.07101904
111TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06670377
112CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02698973
113STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02660738
114* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01257813
115KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00546051
116SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.00493846
117DCP1A_22483619_ChIP-Seq_HELA_Human0.99134698
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99120349
119* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98800977
120GATA6_25053715_ChIP-Seq_YYC3_Human0.98060282
121DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98057103
122KDM5A_27292631_Chip-Seq_BREAST_Human0.97897837
123ELK1_19687146_ChIP-ChIP_HELA_Human0.95661716
124* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95478608
125* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94362041
126* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93578166
127NANOG_21062744_ChIP-ChIP_HESCs_Human0.93369687
128SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.93080867
129TP63_19390658_ChIP-ChIP_HaCaT_Human0.92620760
130* TBX20_22328084_ChIP-Seq_HEART_Mouse0.92346805
131* TBX20_22080862_ChIP-Seq_HEART_Mouse0.92346805
132ETS1_20019798_ChIP-Seq_JURKAT_Human0.91996927
133NANOG_18692474_ChIP-Seq_MEFs_Mouse0.91812858
134HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91810819
135NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90767138
136RACK7_27058665_Chip-Seq_MCF-7_Human0.90649696
137POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.90192994
138GATA1_26923725_Chip-Seq_HPCs_Mouse0.89505299
139POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.89431504
140EGR1_19374776_ChIP-ChIP_THP-1_Human0.88970093
141KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.88342123
142* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.85358272
143TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.82432738
144YY1_21170310_ChIP-Seq_MESCs_Mouse0.81849034
145SRF_21415370_ChIP-Seq_HL-1_Mouse0.80922730
146NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.80648243
147TBX3_20139965_ChIP-Seq_ESCs_Mouse0.77606844

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development5.09940335
2MP0004084_abnormal_cardiac_muscle3.22286193
3MP0002254_reproductive_system_inflammat3.10071934
4MP0004147_increased_porphyrin_level2.95918625
5MP0003890_abnormal_embryonic-extraembry2.90756028
6MP0004272_abnormal_basement_membrane2.85779546
7MP0006054_spinal_hemorrhage2.78348963
8MP0005623_abnormal_meninges_morphology2.76848368
9MP0003806_abnormal_nucleotide_metabolis2.67876188
10MP0008058_abnormal_DNA_repair2.64519339
11MP0004215_abnormal_myocardial_fiber2.35903309
12MP0003950_abnormal_plasma_membrane2.31376442
13MP0003705_abnormal_hypodermis_morpholog2.31191988
14MP0005167_abnormal_blood-brain_barrier2.26648584
15MP0005330_cardiomyopathy2.22518031
16MP0001293_anophthalmia2.15058331
17MP0000579_abnormal_nail_morphology2.04764880
18MP0003567_abnormal_fetal_cardiomyocyte1.98273862
19MP0006292_abnormal_olfactory_placode1.98214670
20MP0010352_gastrointestinal_tract_polyps1.97198155
21MP0003718_maternal_effect1.94888837
22MP0010030_abnormal_orbit_morphology1.94456664
23MP0008007_abnormal_cellular_replicative1.94012788
24MP0001730_embryonic_growth_arrest1.93951073
25MP0004957_abnormal_blastocyst_morpholog1.93704315
26MP0010630_abnormal_cardiac_muscle1.90671682
27MP0009697_abnormal_copulation1.79069890
28MP0008775_abnormal_heart_ventricle1.78610199
29MP0004036_abnormal_muscle_relaxation1.77091399
30MP0003136_yellow_coat_color1.74588945
31MP0006138_congestive_heart_failure1.74111889
32MP0003984_embryonic_growth_retardation1.73301319
33MP0004185_abnormal_adipocyte_glucose1.71321658
34MP0004264_abnormal_extraembryonic_tissu1.70451702
35MP0002088_abnormal_embryonic_growth/wei1.70420106
36MP0001879_abnormal_lymphatic_vessel1.68283241
37MP0002086_abnormal_extraembryonic_tissu1.66774765
38MP0005380_embryogenesis_phenotype1.64015526
39MP0001672_abnormal_embryogenesis/_devel1.64015526
40MP0010368_abnormal_lymphatic_system1.59168135
41MP0005666_abnormal_adipose_tissue1.57383889
42MP0001915_intracranial_hemorrhage1.55614722
43MP0009384_cardiac_valve_regurgitation1.52844528
44MP0003119_abnormal_digestive_system1.52471235
45MP0004087_abnormal_muscle_fiber1.52080155
46MP0003221_abnormal_cardiomyocyte_apopto1.49645670
47MP0004484_altered_response_of1.45939183
48MP0005385_cardiovascular_system_phenoty1.45831216
49MP0001544_abnormal_cardiovascular_syste1.45831216
50MP0004197_abnormal_fetal_growth/weight/1.44317642
51MP0008877_abnormal_DNA_methylation1.42601977
52MP0008438_abnormal_cutaneous_collagen1.41152214
53MP0002837_dystrophic_cardiac_calcinosis1.41118974
54MP0002233_abnormal_nose_morphology1.39428002
55MP0001286_abnormal_eye_development1.39331967
56MP0002972_abnormal_cardiac_muscle1.38513414
57MP0001697_abnormal_embryo_size1.36847197
58MP0010234_abnormal_vibrissa_follicle1.36034158
59MP0002111_abnormal_tail_morphology1.33819818
60MP0010094_abnormal_chromosome_stability1.31244804
61MP0001188_hyperpigmentation1.29855357
62MP0002084_abnormal_developmental_patter1.29048203
63MP0000428_abnormal_craniofacial_morphol1.27254278
64MP0009703_decreased_birth_body1.26642767
65MP0005360_urolithiasis1.26024652
66MP0001299_abnormal_eye_distance/1.25751247
67MP0003656_abnormal_erythrocyte_physiolo1.25115798
68MP0003011_delayed_dark_adaptation1.24055430
69MP0000747_muscle_weakness1.23974924
70MP0003111_abnormal_nucleus_morphology1.22869497
71MP0000762_abnormal_tongue_morphology1.22676441
72MP0002938_white_spotting1.21259486
73MP0002127_abnormal_cardiovascular_syste1.21092737
74MP0005085_abnormal_gallbladder_physiolo1.19572473
75MP0000751_myopathy1.19085829
76MP0003566_abnormal_cell_adhesion1.18946739
77MP0003077_abnormal_cell_cycle1.17750128
78MP0009840_abnormal_foam_cell1.17179359
79MP0000750_abnormal_muscle_regeneration1.17089376
80MP0002269_muscular_atrophy1.15292127
81MP0000749_muscle_degeneration1.15287625
82MP0004130_abnormal_muscle_cell1.15010875
83MP0000049_abnormal_middle_ear1.13715016
84MP0002080_prenatal_lethality1.13527246
85MP0004233_abnormal_muscle_weight1.13127562
86MP0003828_pulmonary_edema1.11461801
87MP0000733_abnormal_muscle_development1.08333638
88MP0002925_abnormal_cardiovascular_devel1.07639156
89MP0000537_abnormal_urethra_morphology1.06769772
90MP0005266_abnormal_metabolism1.05624691
91MP0003123_paternal_imprinting1.05547353
92MP0000266_abnormal_heart_morphology1.05440182
93MP0002092_abnormal_eye_morphology1.05176777
94MP0003385_abnormal_body_wall1.05010298
95MP0002796_impaired_skin_barrier1.04971879
96MP0002085_abnormal_embryonic_tissue1.04845443
97MP0005620_abnormal_muscle_contractility1.04515132
98MP0003786_premature_aging1.04238680
99MP0003315_abnormal_perineum_morphology1.03218569
100MP0000350_abnormal_cell_proliferation1.02649123
101MP0005165_increased_susceptibility_to1.02261110
102MP0003755_abnormal_palate_morphology1.01815010
103MP0002332_abnormal_exercise_endurance1.01011935
104MP0010678_abnormal_skin_adnexa1.00456988
105MP0000432_abnormal_head_morphology1.00266591
106MP0002128_abnormal_blood_circulation1.00156114
107MP0002139_abnormal_hepatobiliary_system0.99198099
108MP0003646_muscle_fatigue0.98857372
109MP0008932_abnormal_embryonic_tissue0.96263926
110MP0003693_abnormal_embryo_hatching0.95514725
111MP0004133_heterotaxia0.92158847
112MP0003861_abnormal_nervous_system0.91805242
113MP0005375_adipose_tissue_phenotype0.91254866
114MP0000313_abnormal_cell_death0.90153487
115MP0010307_abnormal_tumor_latency0.90024003
116MP0003935_abnormal_craniofacial_develop0.89525221
117MP0006035_abnormal_mitochondrial_morpho0.89221885
118MP0001177_atelectasis0.89080666
119MP0005408_hypopigmentation0.88619429
120MP0006036_abnormal_mitochondrial_physio0.88243955
121MP0003937_abnormal_limbs/digits/tail_de0.87217232
122MP0008057_abnormal_DNA_replication0.86569753
123MP0001614_abnormal_blood_vessel0.85739790
124MP0003091_abnormal_cell_migration0.85011324
125MP0005076_abnormal_cell_differentiation0.85006251
126MP0005023_abnormal_wound_healing0.82811580
127MP0001661_extended_life_span0.81008340
128MP0005670_abnormal_white_adipose0.80792488
129MP0001529_abnormal_vocalization0.79705808
130MP0000647_abnormal_sebaceous_gland0.78041142
131MP0003279_aneurysm0.77794680
132MP0003137_abnormal_impulse_conducting0.77579242
133MP0002106_abnormal_muscle_physiology0.77143479
134MP0003121_genomic_imprinting0.76262824
135MP0000566_synostosis0.76211425
136MP0001849_ear_inflammation0.75439292
137MP0005501_abnormal_skin_physiology0.74966872
138MP0009250_abnormal_appendicular_skeleto0.74448204
139MP0003115_abnormal_respiratory_system0.73431185
140MP0010329_abnormal_lipoprotein_level0.73177936
141MP0002090_abnormal_vision0.72975609
142MP0003942_abnormal_urinary_system0.72527705
143MP0009053_abnormal_anal_canal0.71563932
144MP0001727_abnormal_embryo_implantation0.71426836
145MP0002697_abnormal_eye_size0.71269979
146MP0009672_abnormal_birth_weight0.70979767
147MP0002396_abnormal_hematopoietic_system0.70940082
148MP0006072_abnormal_retinal_apoptosis0.70603592
149MP0003300_gastrointestinal_ulcer0.70114206
150MP0004085_abnormal_heartbeat0.68603591
151MP0005391_vision/eye_phenotype0.68363123
152MP0002210_abnormal_sex_determination0.65448775
153MP0008789_abnormal_olfactory_epithelium0.65375248
154MP0001145_abnormal_male_reproductive0.64855101
155MP0000467_abnormal_esophagus_morphology0.63946781
156MP0002081_perinatal_lethality0.62737851
157MP0000358_abnormal_cell_content/0.62595658
158MP0001346_abnormal_lacrimal_gland0.61132105
159MP0000490_abnormal_crypts_of0.60576071
160MP0005187_abnormal_penis_morphology0.59258052

Predicted human phenotypes

RankGene SetZ-score
1Confusion (HP:0001289)3.88262945
2Colon cancer (HP:0003003)3.65441546
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.56296422
4Abnormal lung lobation (HP:0002101)3.47607746
5Rhabdomyolysis (HP:0003201)3.43536349
6Chromsome breakage (HP:0040012)3.43486032
7Myoglobinuria (HP:0002913)3.37687844
8Sudden death (HP:0001699)3.28194089
9Muscle fiber splitting (HP:0003555)3.26859478
10Ventricular tachycardia (HP:0004756)3.26506145
11Septo-optic dysplasia (HP:0100842)3.24561373
12Reticulocytosis (HP:0001923)3.22578658
13Abnormality of the labia minora (HP:0012880)3.15180089
14Nephroblastoma (Wilms tumor) (HP:0002667)3.12443757
15Right ventricular cardiomyopathy (HP:0011663)3.12064459
16Hyporeflexia of lower limbs (HP:0002600)3.08077265
17Embryonal renal neoplasm (HP:0011794)3.07899019
18Meckel diverticulum (HP:0002245)2.99890464
19* Exercise-induced muscle cramps (HP:0003710)2.95679169
20Paralysis (HP:0003470)2.86451776
21Abnormality of chromosome stability (HP:0003220)2.84173655
22Increased connective tissue (HP:0009025)2.83711835
23Abnormality of the ileum (HP:0001549)2.79864651
24Megaloblastic anemia (HP:0001889)2.74310626
25Cortical dysplasia (HP:0002539)2.66893479
26Bilateral microphthalmos (HP:0007633)2.56850002
27Lipoatrophy (HP:0100578)2.54056991
28Absent radius (HP:0003974)2.51866649
29Hyperammonemia (HP:0001987)2.50813540
30Deep venous thrombosis (HP:0002625)2.47837552
31Intrahepatic cholestasis (HP:0001406)2.46787123
32Hepatoblastoma (HP:0002884)2.46239715
33Difficulty running (HP:0009046)2.45547287
34Metaphyseal cupping (HP:0003021)2.44489130
35Multiple enchondromatosis (HP:0005701)2.43311076
36Abnormality of reticulocytes (HP:0004312)2.43099897
37Esophageal varix (HP:0002040)2.42246891
38Choanal stenosis (HP:0000452)2.41748923
39Aplasia/Hypoplasia of the uvula (HP:0010293)2.41560352
40Bifid tongue (HP:0010297)2.40173849
41Increased serum pyruvate (HP:0003542)2.39344360
42Abnormality of glycolysis (HP:0004366)2.39344360
43Facial cleft (HP:0002006)2.39124735
44Increased nuchal translucency (HP:0010880)2.38765515
45Abnormality of the preputium (HP:0100587)2.37327096
46Aplasia involving forearm bones (HP:0009822)2.35641183
47Absent forearm bone (HP:0003953)2.35641183
48Atrial fibrillation (HP:0005110)2.34920579
49Myelomeningocele (HP:0002475)2.34209814
50Hypoalphalipoproteinemia (HP:0003233)2.32634716
51Deviation of the thumb (HP:0009603)2.31372425
52Spastic diplegia (HP:0001264)2.31362288
53Duodenal stenosis (HP:0100867)2.30942275
54Small intestinal stenosis (HP:0012848)2.30942275
55Xanthomatosis (HP:0000991)2.30679220
56Abnormality of iron homeostasis (HP:0011031)2.29813269
57Abnormality of dicarboxylic acid metabolism (HP:0010995)2.28765262
58Dicarboxylic aciduria (HP:0003215)2.28765262
59Hypolipoproteinemia (HP:0010981)2.26049130
60Homocystinuria (HP:0002156)2.24984223
61Abnormality of homocysteine metabolism (HP:0010919)2.24984223
62Dilated cardiomyopathy (HP:0001644)2.24164611
63Proximal placement of thumb (HP:0009623)2.22887681
64Palpitations (HP:0001962)2.21975092
65Abnormality of the septum pellucidum (HP:0007375)2.21532987
66Ileus (HP:0002595)2.20870757
67Abnormality of the duodenum (HP:0002246)2.19882408
68Rhabdomyosarcoma (HP:0002859)2.19670035
69Short humerus (HP:0005792)2.17872353
70Absent septum pellucidum (HP:0001331)2.17745353
71Supraventricular arrhythmia (HP:0005115)2.16378313
72Absent eyebrow (HP:0002223)2.16200785
73Abnormality of the vitamin B12 metabolism (HP:0004341)2.14874337
74Abnormal cartilage morphology (HP:0002763)2.13573365
75Abnormality of serum amino acid levels (HP:0003112)2.12815465
76Medulloblastoma (HP:0002885)2.12402972
77Reticulocytopenia (HP:0001896)2.11894019
78Hyperglycinemia (HP:0002154)2.10079225
79Aplasia/hypoplasia of the humerus (HP:0006507)2.09960055
80Abnormality of glycine metabolism (HP:0010895)2.09714786
81Abnormality of serine family amino acid metabolism (HP:0010894)2.09714786
82Maternal diabetes (HP:0009800)2.08111185
83Primary atrial arrhythmia (HP:0001692)2.07355962
84Hypobetalipoproteinemia (HP:0003563)2.07034293
85Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.06279496
86Acanthocytosis (HP:0001927)2.05790832
87Abnormality of transition element cation homeostasis (HP:0011030)2.05749075
88Supraventricular tachycardia (HP:0004755)2.05679148
89Hepatocellular carcinoma (HP:0001402)2.05281108
90Neoplasm of the colon (HP:0100273)2.03778305
91Aplasia/Hypoplasia of the sternum (HP:0006714)2.03668115
92Macrocytic anemia (HP:0001972)2.03585312
93Diaphragmatic weakness (HP:0009113)2.03444389
94Abnormality of cells of the erythroid lineage (HP:0012130)1.99606755
95Polycythemia (HP:0001901)1.98694581
96Selective tooth agenesis (HP:0001592)1.97358830
97Ectopic kidney (HP:0000086)1.96579450
98Short middle phalanx of the 5th finger (HP:0004220)1.96120054
99Breast aplasia (HP:0100783)1.94747893
100Stenosis of the external auditory canal (HP:0000402)1.94558074
101Hyperglycinuria (HP:0003108)1.93547447
102Poikilocytosis (HP:0004447)1.93321533
103Aplasia/Hypoplasia of the breasts (HP:0010311)1.93019484
104Absent eyelashes (HP:0000561)1.92916582
105Increased serum ferritin (HP:0003281)1.91696855
106Abnormality of vitamin B metabolism (HP:0004340)1.90879934
107Abnormality of the lacrimal duct (HP:0011481)1.90780569
108EMG: myopathic abnormalities (HP:0003458)1.90687151
109Nonimmune hydrops fetalis (HP:0001790)1.90102629
110* Hypoglycemic coma (HP:0001325)1.89565606
111Adenoma sebaceum (HP:0009720)1.89506160
112Angiofibromas (HP:0010615)1.89506160
113Triphalangeal thumb (HP:0001199)1.89480214
114Abnormality of vitamin metabolism (HP:0100508)1.88843971
115Abnormality of fatty-acid metabolism (HP:0004359)1.88838085
116Skull defect (HP:0001362)1.87005438
117Horseshoe kidney (HP:0000085)1.86174849
118Hypopigmentation of the fundus (HP:0007894)1.85661335
119Esophageal atresia (HP:0002032)1.83931153
120Neoplasm of the rectum (HP:0100743)1.81874864
121Duplication of thumb phalanx (HP:0009942)1.81839505
122Gastrointestinal atresia (HP:0002589)1.81329583
123Gastrointestinal carcinoma (HP:0002672)1.79710373
124Malignant gastrointestinal tract tumors (HP:0006749)1.79710373
125Glioma (HP:0009733)1.79430323
126Insidious onset (HP:0003587)1.79148383
127Termporal pattern (HP:0011008)1.79148383
128Ependymoma (HP:0002888)1.78916490
129Short hallux (HP:0010109)1.78854965
130Anophthalmia (HP:0000528)1.78661123
131Lymphangioma (HP:0100764)1.77314275
132Hypoplasia of the iris (HP:0007676)1.77058405
133Abnormal umbilical cord blood vessels (HP:0011403)1.76469606
134Single umbilical artery (HP:0001195)1.76469606
135Abnormality of the fetal cardiovascular system (HP:0010948)1.76469606
136Progressive external ophthalmoplegia (HP:0000590)1.76386976
137Preaxial foot polydactyly (HP:0001841)1.76155352
138Gonadotropin excess (HP:0000837)1.75838006
139Abnormal number of incisors (HP:0011064)1.75820986
140Choanal atresia (HP:0000453)1.75742395
141Ulnar bowing (HP:0003031)1.75353867
142Neoplasm of the small intestine (HP:0100833)1.74754143
143Biliary tract neoplasm (HP:0100574)1.74753982
144Nausea (HP:0002018)1.74584763
145Aplasia/Hypoplasia of the hallux (HP:0008362)1.74576105
146Subacute progressive viral hepatitis (HP:0006572)1.74555734
147Microvesicular hepatic steatosis (HP:0001414)1.74377205
148Cutaneous syndactyly (HP:0012725)1.74181295
149Abnormality of the heme biosynthetic pathway (HP:0010472)1.73317737
150Abnormality of aspartate family amino acid metabolism (HP:0010899)1.72913447
151Abnormal number of erythroid precursors (HP:0012131)1.72170696
152Uterine neoplasm (HP:0010784)1.72073890
153Subaortic stenosis (HP:0001682)1.71982962
154Abnormality of the left ventricular outflow tract (HP:0011103)1.71982962
155Abnormality of methionine metabolism (HP:0010901)1.68619311
156Progressive muscle weakness (HP:0003323)1.68365274
157Premature rupture of membranes (HP:0001788)1.68362427
158Abnormality of the nasolacrimal system (HP:0000614)1.68360115
159Missing ribs (HP:0000921)1.68108377
160Pterygium (HP:0001059)1.68040760
161Exercise-induced myalgia (HP:0003738)1.68014007
162Embryonal neoplasm (HP:0002898)1.67972332
163Abnormality of the umbilical cord (HP:0010881)1.67925976
164Absent hair (HP:0002298)1.67839956
165Abnormality of the carotid arteries (HP:0005344)1.67433756
166Calf muscle hypertrophy (HP:0008981)1.67401607
167Ovarian neoplasm (HP:0100615)1.66631311
168Atrioventricular block (HP:0001678)1.65235375
169High anterior hairline (HP:0009890)1.65024246
170Abnormality of cochlea (HP:0000375)1.64922987
171Volvulus (HP:0002580)1.64156745
172Cholelithiasis (HP:0001081)1.63786424
173Abnormal vertebral ossification (HP:0100569)1.63136244
174Birth length less than 3rd percentile (HP:0003561)1.61967501
175Abnormality of the salivary glands (HP:0010286)1.61598819
176Micronodular cirrhosis (HP:0001413)1.61383948
177Scapular winging (HP:0003691)1.61204551
178Difficulty climbing stairs (HP:0003551)1.60441865

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN23.57277280
2KDR3.25114659
3SRPK13.11861706
4SCYL22.95421009
5TIE12.83731996
6MKNK22.60628399
7STK102.43858828
8EEF2K2.41778248
9VRK22.39483075
10TNIK2.38580211
11TAF12.37587680
12TTN2.26202154
13TRIB32.07452879
14RPS6KB22.05471642
15NEK12.04213206
16MET2.04152115
17MAP3K102.02703526
18CDC71.98086163
19LRRK21.89941338
20WEE11.64417508
21MAP3K81.55216915
22LATS21.55032050
23CDK121.53055856
24PDK31.50661413
25PDK41.50661413
26TTK1.49372196
27MST41.45761144
28VRK11.37041381
29CHEK21.35190946
30TRIM281.34763654
31GRK11.33082473
32STK41.31793766
33LMTK21.28634414
34STK38L1.26813618
35STK391.24310728
36EPHA21.23479157
37PNCK1.23472843
38FLT31.20643576
39PAK41.17801168
40TLK11.17800635
41ATR1.15638035
42NUAK11.15374283
43STK161.14771604
44NEK21.12497477
45PDGFRA1.11094108
46PDK21.10967752
47NME11.10129462
48OBSCN1.07171792
49BMPR1B1.05969987
50CDK41.05659296
51WNK31.05534408
52BCKDK1.05478834
53NME21.04142755
54BRD41.03989152
55BUB11.03914687
56BMX1.03572430
57TESK21.02384772
58SMG10.99161678
59PTK60.98166094
60EIF2AK20.97615680
61ACVR1B0.96817564
62AURKB0.94198760
63FGFR20.94196149
64CDK60.93162885
65DYRK30.92872144
66PAK20.92866693
67TRPM70.92769087
68LATS10.89848852
69MAP2K20.89453274
70TGFBR10.89055452
71ALK0.87582118
72ICK0.87533206
73CSNK1G10.87526347
74DMPK0.85881224
75STK30.81987220
76BRSK10.81746854
77ROCK20.78844561
78AKT20.77993225
79MTOR0.75950270
80BCR0.75693021
81EPHB10.72943930
82PRKG20.70721849
83EIF2AK30.70526973
84PRKAA20.70319485
85MAP3K30.69513180
86FGFR10.69172564
87MELK0.68876729
88PIM10.68873451
89PBK0.68100884
90MAP2K30.67885759
91CAMK1D0.65617426
92GRK60.65373251
93TSSK60.63595749
94PRKD10.63229995
95ZAK0.62975499
96PLK20.62921617
97DYRK20.61683281
98PASK0.61284277
99CDK10.61208548
100CHEK10.59248813
101CSNK1D0.58196925
102PAK30.57601501
103CSNK1E0.57280681
104ILK0.56722475
105CDK20.56138613
106BRSK20.55183959
107TGFBR20.54756491
108PLK10.54462629
109PHKG10.53864677
110PHKG20.53864677
111DDR20.52292015
112RIPK10.51756318
113RPS6KA40.51673414
114PRKDC0.51216680
115CDK70.50927301
116GSK3A0.50042434
117AURKA0.49990367
118ITK0.49197184
119LIMK10.48201305
120SIK10.47885292
121MAP2K10.47466265
122NLK0.47356625
123EIF2AK10.47022108
124CSNK2A10.46893075
125FGR0.46472112
126CLK10.46260385
127MKNK10.46129574
128BRAF0.45845681
129CSNK2A20.45716596
130CAMK1G0.44217064
131ERBB40.43846204
132CAMK2D0.43467818
133PTK20.43433860
134CSNK1G20.42842312
135PDGFRB0.42700873
136CSNK1G30.41973902
137CDK190.41769815
138ATM0.40893788
139PLK40.40800357
140PLK30.40609005
141MAP3K90.40502182
142STK240.39766313
143CSNK1A1L0.38317161
144YES10.38153341
145CDK30.36842791
146OXSR10.30228078
147NTRK10.26429367

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.86958526
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.94034043
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.71075405
4Systemic lupus erythematosus_Homo sapiens_hsa053222.58735703
5Proteasome_Homo sapiens_hsa030502.49906569
6Fatty acid degradation_Homo sapiens_hsa000712.42279222
7Homologous recombination_Homo sapiens_hsa034402.38271652
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.36048995
9Propanoate metabolism_Homo sapiens_hsa006402.31510232
10Carbon metabolism_Homo sapiens_hsa012002.25920415
11One carbon pool by folate_Homo sapiens_hsa006702.09677316
12DNA replication_Homo sapiens_hsa030302.09433791
13Fatty acid metabolism_Homo sapiens_hsa012122.09396129
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.05211331
15RNA polymerase_Homo sapiens_hsa030202.03177365
16Biosynthesis of amino acids_Homo sapiens_hsa012301.93151740
17Fatty acid elongation_Homo sapiens_hsa000621.86108616
18Arginine biosynthesis_Homo sapiens_hsa002201.80118179
19Fanconi anemia pathway_Homo sapiens_hsa034601.79420365
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.78693003
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.71753287
22Steroid biosynthesis_Homo sapiens_hsa001001.68182644
23Basal transcription factors_Homo sapiens_hsa030221.64937470
24Protein export_Homo sapiens_hsa030601.61831759
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53572307
26Pyruvate metabolism_Homo sapiens_hsa006201.51464849
27Arginine and proline metabolism_Homo sapiens_hsa003301.45540908
28Mismatch repair_Homo sapiens_hsa034301.44481254
29PPAR signaling pathway_Homo sapiens_hsa033201.41926895
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.40452148
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.35705553
32Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.35161836
33Pyrimidine metabolism_Homo sapiens_hsa002401.27051296
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18534120
35RNA transport_Homo sapiens_hsa030131.18519182
36Fatty acid biosynthesis_Homo sapiens_hsa000611.17374173
37Small cell lung cancer_Homo sapiens_hsa052221.16902928
38Selenocompound metabolism_Homo sapiens_hsa004501.15813641
39Vitamin digestion and absorption_Homo sapiens_hsa049771.14204477
40Central carbon metabolism in cancer_Homo sapiens_hsa052301.13748708
41Basal cell carcinoma_Homo sapiens_hsa052171.11713570
42Fat digestion and absorption_Homo sapiens_hsa049751.10410040
43Bile secretion_Homo sapiens_hsa049761.10001729
44Adherens junction_Homo sapiens_hsa045201.09319397
45Cell cycle_Homo sapiens_hsa041101.08831432
46Tight junction_Homo sapiens_hsa045301.07302073
47HIF-1 signaling pathway_Homo sapiens_hsa040661.04572643
48Ribosome_Homo sapiens_hsa030101.04116839
49Purine metabolism_Homo sapiens_hsa002301.03414189
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.02515349
51beta-Alanine metabolism_Homo sapiens_hsa004101.00933820
52p53 signaling pathway_Homo sapiens_hsa041151.00671933
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99641857
54ECM-receptor interaction_Homo sapiens_hsa045120.98112784
55Oocyte meiosis_Homo sapiens_hsa041140.96904151
56Viral carcinogenesis_Homo sapiens_hsa052030.96009559
57Lysine degradation_Homo sapiens_hsa003100.94518134
58Vitamin B6 metabolism_Homo sapiens_hsa007500.93615740
59Pentose phosphate pathway_Homo sapiens_hsa000300.92803891
60Spliceosome_Homo sapiens_hsa030400.90795435
61Butanoate metabolism_Homo sapiens_hsa006500.90244189
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89368386
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87638630
64Tryptophan metabolism_Homo sapiens_hsa003800.87007043
65Nucleotide excision repair_Homo sapiens_hsa034200.85864262
66Wnt signaling pathway_Homo sapiens_hsa043100.84797478
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.84775640
68Alcoholism_Homo sapiens_hsa050340.83948031
69Focal adhesion_Homo sapiens_hsa045100.81661744
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81540487
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80648357
72Huntingtons disease_Homo sapiens_hsa050160.77862590
73Cardiac muscle contraction_Homo sapiens_hsa042600.76173757
74Dilated cardiomyopathy_Homo sapiens_hsa054140.75993176
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.75117561
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74834580
77Hedgehog signaling pathway_Homo sapiens_hsa043400.74595282
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72993802
79MicroRNAs in cancer_Homo sapiens_hsa052060.67593380
80Renal cell carcinoma_Homo sapiens_hsa052110.67583692
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64926163
82Complement and coagulation cascades_Homo sapiens_hsa046100.64312862
83Proteoglycans in cancer_Homo sapiens_hsa052050.64291274
84Oxidative phosphorylation_Homo sapiens_hsa001900.63509089
85Hippo signaling pathway_Homo sapiens_hsa043900.63461727
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62128539
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.61890232
88Sulfur metabolism_Homo sapiens_hsa009200.61241491
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61112011
90Peroxisome_Homo sapiens_hsa041460.60907381
91Folate biosynthesis_Homo sapiens_hsa007900.60479125
92RNA degradation_Homo sapiens_hsa030180.60276034
93Non-homologous end-joining_Homo sapiens_hsa034500.59158512
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.57977595
95AMPK signaling pathway_Homo sapiens_hsa041520.56795218
96Glutathione metabolism_Homo sapiens_hsa004800.56330093
97N-Glycan biosynthesis_Homo sapiens_hsa005100.56281945
98TGF-beta signaling pathway_Homo sapiens_hsa043500.56192858
99Insulin resistance_Homo sapiens_hsa049310.55794351
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54869945
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54645025
102Thyroid cancer_Homo sapiens_hsa052160.54121327
103Viral myocarditis_Homo sapiens_hsa054160.51256657
104Tyrosine metabolism_Homo sapiens_hsa003500.50877561
105Metabolic pathways_Homo sapiens_hsa011000.49614076
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48749951
107Base excision repair_Homo sapiens_hsa034100.48126547
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46907014
109Drug metabolism - other enzymes_Homo sapiens_hsa009830.46123452
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45498829
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43642123
112Starch and sucrose metabolism_Homo sapiens_hsa005000.42954575
113Parkinsons disease_Homo sapiens_hsa050120.42611954
114Sulfur relay system_Homo sapiens_hsa041220.41176043
115Glycerolipid metabolism_Homo sapiens_hsa005610.40300597
116Phenylalanine metabolism_Homo sapiens_hsa003600.39927082
117Galactose metabolism_Homo sapiens_hsa000520.39382249
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38283575
119Bladder cancer_Homo sapiens_hsa052190.38149909
120Caffeine metabolism_Homo sapiens_hsa002320.38112941
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35988700
122Alzheimers disease_Homo sapiens_hsa050100.35532303
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35480556
124Glucagon signaling pathway_Homo sapiens_hsa049220.35287080
125Cyanoamino acid metabolism_Homo sapiens_hsa004600.34200460
126Mineral absorption_Homo sapiens_hsa049780.33842567
127mRNA surveillance pathway_Homo sapiens_hsa030150.33298633
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30875891
129Colorectal cancer_Homo sapiens_hsa052100.30599801
130Prostate cancer_Homo sapiens_hsa052150.28148313
131Melanoma_Homo sapiens_hsa052180.27319022
132Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25232651
133Pathways in cancer_Homo sapiens_hsa052000.21645289
134Retinol metabolism_Homo sapiens_hsa008300.14095925

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »