ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	axonemal dynein complex assembly (GO:0070286)	8.63186500
2	cilium or flagellum-dependent cell motility (GO:0001539)	8.00433029
3	motile cilium assembly (GO:0044458)	6.16282389
4	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	5.92174830
5	L-phenylalanine catabolic process (GO:0006559)	5.92174830
6	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	5.75508749
7	L-phenylalanine metabolic process (GO:0006558)	5.75508749
8	cilium movement (GO:0003341)	5.49516390
9	GDP-mannose metabolic process (GO:0019673)	5.11693917
10	thyroid hormone generation (GO:0006590)	4.97730564
11	aromatic amino acid family catabolic process (GO:0009074)	4.95595747
12	ethanol oxidation (GO:0006069)	4.78188324
13	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	4.63545396
14	glyoxylate metabolic process (GO:0046487)	4.48856913
15	sulfur amino acid catabolic process (GO:0000098)	4.47040129
16	drug catabolic process (GO:0042737)	4.38797234
17	high-density lipoprotein particle remodeling (GO:0034375)	4.37238051
18	primary alcohol catabolic process (GO:0034310)	4.37209248
19	bile acid biosynthetic process (GO:0006699)	4.35479974
20	cysteine metabolic process (GO:0006534)	4.32242648
21	tryptophan metabolic process (GO:0006568)	4.31904041
22	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.29168244
23	epithelial cilium movement (GO:0003351)	4.26874674
24	alpha-linolenic acid metabolic process (GO:0036109)	4.26750515
25	thyroid hormone metabolic process (GO:0042403)	4.21578785
26	indole-containing compound catabolic process (GO:0042436)	4.20916895
27	indolalkylamine catabolic process (GO:0046218)	4.20916895
28	tryptophan catabolic process (GO:0006569)	4.20916895
29	kynurenine metabolic process (GO:0070189)	4.18466603
30	negative regulation of fibrinolysis (GO:0051918)	4.07435511
31	cellular glucuronidation (GO:0052695)	4.05603688
32	axoneme assembly (GO:0035082)	4.05395724
33	exogenous drug catabolic process (GO:0042738)	3.99219675
34	lung epithelium development (GO:0060428)	3.97525131
35	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	3.94444465
36	glutamate metabolic process (GO:0006536)	3.88892879
37	urea cycle (GO:0000050)	3.88240843
38	urea metabolic process (GO:0019627)	3.88240843
39	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	3.87769903
40	negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)	3.86426744
41	glucuronate metabolic process (GO:0019585)	3.85541783
42	uronic acid metabolic process (GO:0006063)	3.85541783
43	tyrosine metabolic process (GO:0006570)	3.84899841
44	amino-acid betaine metabolic process (GO:0006577)	3.83959982
45	aromatic amino acid family metabolic process (GO:0009072)	3.81262532
46	left/right pattern formation (GO:0060972)	3.77787350
47	regulation of humoral immune response (GO:0002920)	3.74843853
48	lysine metabolic process (GO:0006553)	3.74691849
49	lysine catabolic process (GO:0006554)	3.74691849
50	bile acid metabolic process (GO:0008206)	3.73900953
51	serine family amino acid catabolic process (GO:0009071)	3.70377815
52	regulation of fibrinolysis (GO:0051917)	3.68299356
53	regulation of cholesterol esterification (GO:0010872)	3.67313937
54	vitamin transmembrane transport (GO:0035461)	3.66357537
55	reverse cholesterol transport (GO:0043691)	3.65673588
56	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.64552471
57	nitrogen cycle metabolic process (GO:0071941)	3.64438020
58	response to nitrosative stress (GO:0051409)	3.60831257
59	flavonoid metabolic process (GO:0009812)	3.60594129
60	protein carboxylation (GO:0018214)	3.60111832
61	peptidyl-glutamic acid carboxylation (GO:0017187)	3.60111832
62	tolerance induction (GO:0002507)	3.58334811
63	negative regulation of lipase activity (GO:0060192)	3.57142413
64	cellular ketone body metabolic process (GO:0046950)	3.54369198
65	benzene-containing compound metabolic process (GO:0042537)	3.51377910
66	sensory perception of smell (GO:0007608)	3.50677968
67	regulation of apoptotic cell clearance (GO:2000425)	3.50469624
68	alpha-amino acid catabolic process (GO:1901606)	3.50420503
69	plasma lipoprotein particle remodeling (GO:0034369)	3.50053363
70	protein-lipid complex remodeling (GO:0034368)	3.50053363
71	macromolecular complex remodeling (GO:0034367)	3.50053363
72	short-chain fatty acid metabolic process (GO:0046459)	3.49713588
73	regulation of protein activation cascade (GO:2000257)	3.46703591
74	dicarboxylic acid biosynthetic process (GO:0043650)	3.46208295
75	xenobiotic catabolic process (GO:0042178)	3.45984367
76	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	3.45579869
77	mannose metabolic process (GO:0006013)	3.40088212
78	positive regulation of triglyceride lipase activity (GO:0061365)	3.38777239
79	positive regulation of lipoprotein lipase activity (GO:0051006)	3.38777239
80	negative regulation of cholesterol transport (GO:0032375)	3.37765638
81	negative regulation of sterol transport (GO:0032372)	3.37765638
82	ethanol metabolic process (GO:0006067)	3.37733790
83	drug transmembrane transport (GO:0006855)	3.34905456
84	indolalkylamine metabolic process (GO:0006586)	3.34884605
85	cellular amino acid catabolic process (GO:0009063)	3.34455202
86	phospholipid efflux (GO:0033700)	3.30273426
87	cellular modified amino acid catabolic process (GO:0042219)	3.29834699
88	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	3.28857351
89	acylglycerol homeostasis (GO:0055090)	3.28368228
90	triglyceride homeostasis (GO:0070328)	3.28368228
91	positive regulation of tolerance induction (GO:0002645)	3.26843827
92	renal absorption (GO:0070293)	3.23977313
93	regulation of triglyceride catabolic process (GO:0010896)	3.22074885
94	negative regulation of stress fiber assembly (GO:0051497)	3.22000316
95	aldehyde catabolic process (GO:0046185)	3.21367189
96	regulation of complement activation (GO:0030449)	3.21354092
97	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	3.20254652
98	complement activation, alternative pathway (GO:0006957)	3.18583081
99	antigen processing and presentation of endogenous antigen (GO:0019883)	3.17817647
100	imidazole-containing compound metabolic process (GO:0052803)	3.17143875
101	coenzyme catabolic process (GO:0009109)	3.16661622
102	regulation of cholesterol homeostasis (GO:2000188)	3.16660426
103	regulation of bile acid biosynthetic process (GO:0070857)	3.16012919
104	cholesterol efflux (GO:0033344)	3.15930137
105	regulation of cholesterol biosynthetic process (GO:0045540)	3.15405507
106	negative regulation of B cell mediated immunity (GO:0002713)	3.12045740
107	negative regulation of immunoglobulin mediated immune response (GO:0002890)	3.12045740
108	drug metabolic process (GO:0017144)	3.11140757
109	negative regulation of humoral immune response (GO:0002921)	3.07299758
110	regulation of cholesterol metabolic process (GO:0090181)	3.04477410
111	L-ascorbic acid metabolic process (GO:0019852)	3.03317826
112	ketone body metabolic process (GO:1902224)	3.03169752
113	response to pheromone (GO:0019236)	3.00030822
114	bile acid and bile salt transport (GO:0015721)	2.99686012
115	carnitine metabolic process (GO:0009437)	2.99602678
116	organic acid catabolic process (GO:0016054)	2.97782398
117	carboxylic acid catabolic process (GO:0046395)	2.97782398
118	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.95112092
119	negative regulation of protein activation cascade (GO:2000258)	2.94813183
120	homocysteine metabolic process (GO:0050667)	2.92330865
121	gamma-aminobutyric acid transport (GO:0015812)	2.91413133
122	positive regulation of fatty acid biosynthetic process (GO:0045723)	2.90613400
123	arginine metabolic process (GO:0006525)	2.89503872
124	monocarboxylic acid catabolic process (GO:0072329)	2.89339692
125	drug transport (GO:0015893)	2.87613139
126	regulation of tolerance induction (GO:0002643)	2.86925573
127	fatty acid oxidation (GO:0019395)	2.86816843
128	plasma lipoprotein particle clearance (GO:0034381)	2.85405252
129	positive regulation of extracellular matrix organization (GO:1903055)	2.85045156
130	pyrimidine nucleoside catabolic process (GO:0046135)	2.83122592
131	cellular biogenic amine catabolic process (GO:0042402)	2.83089177
132	amine catabolic process (GO:0009310)	2.83089177
133	aspartate family amino acid catabolic process (GO:0009068)	2.82984114
134	positive regulation of protein kinase C signaling (GO:0090037)	2.82724725
135	low-density lipoprotein particle remodeling (GO:0034374)	2.81811677
136	lipid oxidation (GO:0034440)	2.81678065
137	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)	2.80454034
138	regulation of interleukin-13 production (GO:0032656)	2.78879268
139	positive thymic T cell selection (GO:0045059)	2.78719810
140	regulation of plasminogen activation (GO:0010755)	2.77028847
141	negative regulation of toll-like receptor signaling pathway (GO:0034122)	2.74941897
142	phenylpropanoid metabolic process (GO:0009698)	2.74274202
143	phosphate ion transmembrane transport (GO:0035435)	2.72615541
144	peptidyl-glutamic acid modification (GO:0018200)	2.68836808
145	fibrinolysis (GO:0042730)	2.66994624
146	proline metabolic process (GO:0006560)	2.66924814
147	phosphatidylcholine biosynthetic process (GO:0006656)	2.66577302
148	negative regulation of cell killing (GO:0031342)	2.66027113
149	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	2.66027113
150	regulation of cytokine production involved in inflammatory response (GO:1900015)	2.65346165
151	negative regulation of actin filament bundle assembly (GO:0032232)	2.64785000
152	negative regulation of fatty acid biosynthetic process (GO:0045717)	2.63160439
153	regulation of gamma-delta T cell differentiation (GO:0045586)	2.63103791
154	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.61222656
155	detection of bacterium (GO:0016045)	2.58574373
156	hydrogen peroxide biosynthetic process (GO:0050665)	2.57352590
157	thymic T cell selection (GO:0045061)	2.57214562
158	adenosine receptor signaling pathway (GO:0001973)	2.56731949
159	negative regulation of erythrocyte differentiation (GO:0045647)	2.56084950
160	response to phenylpropanoid (GO:0080184)	2.54475061
161	muscle organ morphogenesis (GO:0048644)	2.53011044
162	protein activation cascade (GO:0072376)	2.51983141
163	positive regulation of steroid metabolic process (GO:0045940)	2.51255954
164	primary alcohol metabolic process (GO:0034308)	2.48921841
165	glutathione biosynthetic process (GO:0006750)	2.46897707
166	regulation of skeletal muscle contraction (GO:0014819)	2.46494422
167	multicellular organismal water homeostasis (GO:0050891)	2.44547721
168	plasma lipoprotein particle assembly (GO:0034377)	2.44462661
169	regulation of fatty acid biosynthetic process (GO:0042304)	2.43697851
170	cellular response to ATP (GO:0071318)	2.42526459
171	sperm capacitation (GO:0048240)	2.42453263
172	regulation of gamma-delta T cell activation (GO:0046643)	2.41185004
173	progesterone metabolic process (GO:0042448)	2.39944759
174	acute-phase response (GO:0006953)	2.39431340
175	regulation of interleukin-5 production (GO:0032674)	2.38657461

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	6.87594433
2	RXR_22158963_ChIP-Seq_LIVER_Mouse	5.24772057
3	PPARA_22158963_ChIP-Seq_LIVER_Mouse	4.32220680
4	LXR_22158963_ChIP-Seq_LIVER_Mouse	4.05726859
5	EGR1_23403033_ChIP-Seq_LIVER_Mouse	3.30072942
6	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	3.22817566
7	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.19565964
8	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	3.15325213
9	VDR_21846776_ChIP-Seq_THP-1_Human	3.13345793
10	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.82709824
11	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.78365966
12	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	2.74177326
13	EZH2_22144423_ChIP-Seq_EOC_Human	2.59812178
14	P68_20966046_ChIP-Seq_HELA_Human	2.41638929
15	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.41303779
16	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.19593003
17	MAF_26560356_Chip-Seq_TH1_Human	2.14202807
18	DROSHA_22980978_ChIP-Seq_HELA_Human	2.03969666
19	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.03787319
20	MAF_26560356_Chip-Seq_TH2_Human	2.02209981
21	ELK3_25401928_ChIP-Seq_HUVEC_Human	2.00921642
22	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.99762978
23	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.98487312
24	MYC_22102868_ChIP-Seq_BL_Human	1.93075877
25	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.92165601
26	BCL6_27268052_Chip-Seq_Bcells_Human	1.84077953
27	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.83955176
28	* SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.83753780
29	BCOR_27268052_Chip-Seq_Bcells_Human	1.82426924
30	GATA1_22025678_ChIP-Seq_K562_Human	1.81710898
31	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.78408602
32	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.76282745
33	* CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.76046782
34	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.75466987
35	UTX_26944678_Chip-Seq_JUKART_Human	1.74286755
36	VDR_24763502_ChIP-Seq_THP-1_Human	1.72792210
37	* SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.70733665
38	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.70486271
39	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.70486271
40	KDM2B_26808549_Chip-Seq_DND41_Human	1.69725293
41	TCF7_22412390_ChIP-Seq_EML_Mouse	1.69426965
42	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.68831174
43	E2F1_20622854_ChIP-Seq_HELA_Human	1.67195299
44	PHF8_20622854_ChIP-Seq_HELA_Human	1.64113115
45	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.56629956
46	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.56445841
47	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.56118137
48	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.52466724
49	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.50233376
50	* RARB_24833708_ChIP-Seq_LIVER_Mouse	1.49050934
51	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.45586065
52	* SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.44469428
53	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.43647053
54	* CTCF_21964334_Chip-Seq_Bcells_Human	1.43233831
55	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.42307049
56	* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.42210323
57	* EZH2_27294783_Chip-Seq_ESCs_Mouse	1.40605808
58	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.39914308
59	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.39841313
60	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.39548865
61	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.38983127
62	CTCF_20526341_ChIP-Seq_ESCs_Human	1.38361458
63	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.37388703
64	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.34948437
65	* SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.34285067
66	LXR_22292898_ChIP-Seq_THP-1_Human	1.32893105
67	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.29356141
68	REST_21632747_ChIP-Seq_MESCs_Mouse	1.29143239
69	* SA1_27219007_Chip-Seq_Bcells_Human	1.29051405
70	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.28941316
71	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.28789407
72	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.27318641
73	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.26917974
74	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.26087081
75	TP53_22127205_ChIP-Seq_IMR90_Human	1.26004241
76	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.25938656
77	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.25866570
78	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.24619280
79	TP63_22573176_ChIP-Seq_HFKS_Human	1.24061283
80	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.23989159
81	* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.23280405
82	* KDM2B_26808549_Chip-Seq_JURKAT_Human	1.22849981
83	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.20715112
84	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.20022697
85	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.18383988
86	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.18166844
87	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.15733837
88	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.14858134
89	* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.14838007
90	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.14415974
91	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.14044303
92	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.12880164
93	P300_27268052_Chip-Seq_Bcells_Human	1.12431913
94	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.12167320
95	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.11841611
96	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.11763439
97	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.10782641
98	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.09519570
99	PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.09001224
100	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.08845054
101	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.08399977
102	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.07801187
103	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.07443565
104	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.07269727
105	ETS1_21867929_ChIP-Seq_TH2_Mouse	1.07181718
106	* SMC3_22415368_ChIP-Seq_MEFs_Mouse	1.06430779
107	* CTCF_26484167_Chip-Seq_Bcells_Mouse	1.05145535
108	KDM2B_26808549_Chip-Seq_K562_Human	1.04466269
109	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.04015475
110	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.03904204
111	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.03104278
112	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.02840433
113	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.02208232
114	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.01819081
115	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.01570215
116	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.01189358
117	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.00281537
118	* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.00040178
119	GBX2_23144817_ChIP-Seq_PC3_Human	0.99784580
120	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.96715672
121	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.95780845
122	CLOCK_20551151_ChIP-Seq_293T_Human	0.94652559
123	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.93720784
124	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.93409612
125	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.92299024
126	ZNF263_19887448_ChIP-Seq_K562_Human	0.91426770
127	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	0.87817809
128	* CTCF_27219007_Chip-Seq_Bcells_Human	0.87214229
129	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.86783308
130	* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.85324210
131	HNF4A_19822575_ChIP-Seq_HepG2_Human	0.83513160
132	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.83512572
133	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.82625854
134	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.82235871
135	HTT_18923047_ChIP-ChIP_STHdh_Human	0.81610166
136	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.81395106
137	GATA1_19941826_ChIP-Seq_K562_Human	0.79041091
138	WT1_25993318_ChIP-Seq_PODOCYTE_Human	0.79029831
139	TET1_21490601_ChIP-Seq_MESCs_Mouse	0.78010761
140	* RACK7_27058665_Chip-Seq_MCF-7_Human	0.77959152
141	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.76742099
142	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.76433294
143	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.75432847
144	* RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.75133449
145	SMC4_20622854_ChIP-Seq_HELA_Human	0.74956099
146	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.73975462
147	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.72953243
148	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.72789494
149	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.72372737
150	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.71509537
151	AHR_22903824_ChIP-Seq_MCF-7_Human	0.70110462
152	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.70083906
153	* CREB1_26743006_Chip-Seq_LNCaP_Human	0.66821152
154	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.66331925
155	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.66066218
156	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.65588925
157	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.65009934
158	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.64963055
159	KDM2B_26808549_Chip-Seq_SUP-B15_Human	0.64519292
160	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.64322868
161	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.63582760
162	BCAT_22108803_ChIP-Seq_LS180_Human	0.63440956
163	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.63389442

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	6.67558370
2	MP0008875_abnormal_xenobiotic_pharmacok	5.75845074
3	MP0005360_urolithiasis	5.71536183
4	MP0005365_abnormal_bile_salt	4.93895742
5	MP0005085_abnormal_gallbladder_physiolo	4.40798523
6	MP0001984_abnormal_olfaction	3.74124898
7	MP0002132_abnormal_respiratory_system	3.57396976
8	MP0005377_hearing/vestibular/ear_phenot	3.17080679
9	MP0003878_abnormal_ear_physiology	3.17080679
10	MP0009840_abnormal_foam_cell	3.14958592
11	MP0010329_abnormal_lipoprotein_level	2.96985254
12	MP0003806_abnormal_nucleotide_metabolis	2.93421811
13	MP0003252_abnormal_bile_duct	2.91483315
14	MP0001986_abnormal_taste_sensitivity	2.86126931
15	MP0003195_calcinosis	2.65063846
16	MP0005083_abnormal_biliary_tract	2.52881184
17	MP0003136_yellow_coat_color	2.47860391
18	MP0005332_abnormal_amino_acid	2.41589851
19	MP0002277_abnormal_respiratory_mucosa	2.31424572
20	MP0004381_abnormal_hair_follicle	2.20794479
21	MP0005409_darkened_coat_color	2.19375680
22	MP0001661_extended_life_span	2.03174641
23	MP0004043_abnormal_pH_regulation	1.99516520
24	MP0003763_abnormal_thymus_physiology	1.96577322
25	MP0004859_abnormal_synaptic_plasticity	1.95310822
26	MP0003436_decreased_susceptibility_to	1.85710803
27	MP0009333_abnormal_splenocyte_physiolog	1.85334654
28	MP0004019_abnormal_vitamin_homeostasis	1.84786685
29	MP0001666_abnormal_nutrient_absorption	1.82679135
30	MP0003172_abnormal_lysosome_physiology	1.78503266
31	MP0003303_peritoneal_inflammation	1.74913191
32	MP0002118_abnormal_lipid_homeostasis	1.73287213
33	MP0003011_delayed_dark_adaptation	1.72528611
34	MP0005584_abnormal_enzyme/coenzyme_acti	1.72359195
35	MP0005387_immune_system_phenotype	1.65140243
36	MP0001790_abnormal_immune_system	1.65140243
37	MP0003191_abnormal_cellular_cholesterol	1.65073637
38	MP0003329_amyloid_beta_deposits	1.62972258
39	MP0002138_abnormal_hepatobiliary_system	1.56086476
40	MP0000003_abnormal_adipose_tissue	1.55287752
41	MP0000685_abnormal_immune_system	1.53485418
42	MP0000013_abnormal_adipose_tissue	1.53230806
43	MP0003868_abnormal_feces_composition	1.47333300
44	MP0010155_abnormal_intestine_physiology	1.47106867
45	MP0003453_abnormal_keratinocyte_physiol	1.46287469
46	MP0003635_abnormal_synaptic_transmissio	1.44530535
47	MP0000609_abnormal_liver_physiology	1.42495771
48	MP0002653_abnormal_ependyma_morphology	1.41094960
49	MP0009745_abnormal_behavioral_response	1.41060659
50	MP0005394_taste/olfaction_phenotype	1.40357290
51	MP0005499_abnormal_olfactory_system	1.40357290
52	MP0005319_abnormal_enzyme/_coenzyme	1.38867650
53	MP0000681_abnormal_thyroid_gland	1.37633026
54	MP0002933_joint_inflammation	1.36822143
55	MP0005666_abnormal_adipose_tissue	1.36466349
56	MP0009643_abnormal_urine_homeostasis	1.35045446
57	MP0005375_adipose_tissue_phenotype	1.35043781
58	MP0001800_abnormal_humoral_immune	1.29973175
59	MP0003879_abnormal_hair_cell	1.27552761
60	MP0005025_abnormal_response_to	1.26015515
61	MP0009046_muscle_twitch	1.24219205
62	MP0001501_abnormal_sleep_pattern	1.22622439
63	MP0002909_abnormal_adrenal_gland	1.20255753
64	MP0005671_abnormal_response_to	1.20095769
65	MP0005058_abnormal_lysosome_morphology	1.19720356
66	MP0004130_abnormal_muscle_cell	1.19276790
67	MP0002272_abnormal_nervous_system	1.17372449
68	MP0003690_abnormal_glial_cell	1.14438280
69	MP0002876_abnormal_thyroid_physiology	1.14410368
70	MP0010234_abnormal_vibrissa_follicle	1.13824148
71	MP0005076_abnormal_cell_differentiation	1.13302301
72	MP0000566_synostosis	1.12881584
73	MP0005623_abnormal_meninges_morphology	1.11852923
74	MP0005464_abnormal_platelet_physiology	1.11724636
75	MP0000604_amyloidosis	1.11670651
76	MP0002063_abnormal_learning/memory/cond	1.11627326
77	MP0010368_abnormal_lymphatic_system	1.11359630
78	MP0002064_seizures	1.11074689
79	MP0005000_abnormal_immune_tolerance	1.11066964
80	MP0000678_abnormal_parathyroid_gland	1.10505654
81	MP0005636_abnormal_mineral_homeostasis	1.09698689
82	MP0002136_abnormal_kidney_physiology	1.06759031
83	MP0004947_skin_inflammation	1.06490923
84	MP0002723_abnormal_immune_serum	1.05999403
85	MP0002822_catalepsy	1.05608493
86	MP0005423_abnormal_somatic_nervous	1.02218670
87	MP0001756_abnormal_urination	1.02103182
88	MP0003091_abnormal_cell_migration	1.01520324
89	MP0002249_abnormal_larynx_morphology	1.01277764
90	MP0008872_abnormal_physiological_respon	1.01046965
91	MP0002405_respiratory_system_inflammati	1.00992879
92	MP0008469_abnormal_protein_level	0.98324296
93	MP0008874_decreased_physiological_sensi	0.98205374
94	MP0008789_abnormal_olfactory_epithelium	0.98158479
95	MP0001879_abnormal_lymphatic_vessel	0.96923780
96	MP0003075_altered_response_to	0.96508116
97	MP0002452_abnormal_antigen_presenting	0.95947535
98	MP0000751_myopathy	0.94476198
99	MP0002572_abnormal_emotion/affect_behav	0.94147097
100	MP0005670_abnormal_white_adipose	0.93466922
101	MP0005535_abnormal_body_temperature	0.92899391
102	MP0003186_abnormal_redox_activity	0.92831974
103	MP0009764_decreased_sensitivity_to	0.91667899
104	MP0002420_abnormal_adaptive_immunity	0.91367566
105	MP0009785_altered_susceptibility_to	0.90726881
106	MP0008569_lethality_at_weaning	0.90601607
107	MP0001819_abnormal_immune_cell	0.90551821
108	MP0005330_cardiomyopathy	0.90217698
109	MP0001765_abnormal_ion_homeostasis	0.90209998
110	MP0005084_abnormal_gallbladder_morpholo	0.89111511
111	MP0004185_abnormal_adipocyte_glucose	0.88823812
112	MP0004885_abnormal_endolymph	0.86941020
113	MP0005174_abnormal_tail_pigmentation	0.85783424
114	MP0005645_abnormal_hypothalamus_physiol	0.84229903
115	MP0009765_abnormal_xenobiotic_induced	0.84020703
116	MP0003866_abnormal_defecation	0.82231759
117	MP0003638_abnormal_response/metabolism_	0.82203931
118	MP0002398_abnormal_bone_marrow	0.81426217
119	MP0001764_abnormal_homeostasis	0.81134709
120	MP0000249_abnormal_blood_vessel	0.80991739
121	MP0000858_altered_metastatic_potential	0.80835109
122	MP0002419_abnormal_innate_immunity	0.79132548
123	MP0002557_abnormal_social/conspecific_i	0.78977793
124	MP0002078_abnormal_glucose_homeostasis	0.78963621
125	MP0001958_emphysema	0.78199625
126	MP0001845_abnormal_inflammatory_respons	0.77511094
127	MP0009697_abnormal_copulation	0.77208646
128	MP0001849_ear_inflammation	0.76894505
129	MP0000716_abnormal_immune_system	0.76827501
130	MP0001873_stomach_inflammation	0.76538028
131	MP0002102_abnormal_ear_morphology	0.76411825
132	MP0005220_abnormal_exocrine_pancreas	0.76222564
133	MP0001968_abnormal_touch/_nociception	0.74834616
134	MP0005171_absent_coat_pigmentation	0.73926069
135	MP0001835_abnormal_antigen_presentation	0.73905695
136	MP0002734_abnormal_mechanical_nocicepti	0.73535212
137	MP0006036_abnormal_mitochondrial_physio	0.72881840
138	MP0001440_abnormal_grooming_behavior	0.72016070
139	MP0002067_abnormal_sensory_capabilities	0.71893801
140	MP0004270_analgesia	0.70829601
141	MP0009642_abnormal_blood_homeostasis	0.70620527
142	MP0003633_abnormal_nervous_system	0.70234376
143	MP0003953_abnormal_hormone_level	0.70017930
144	MP0005647_abnormal_sex_gland	0.68585564
145	MP0003705_abnormal_hypodermis_morpholog	0.66864089
146	MP0005167_abnormal_blood-brain_barrier	0.65882343
147	MP0002184_abnormal_innervation	0.65651242
148	MP0002736_abnormal_nociception_after	0.64325170
149	MP0004782_abnormal_surfactant_physiolog	0.63958903
150	MP0002168_other_aberrant_phenotype	0.63257468
151	MP0001177_atelectasis	0.62921943
152	MP0002971_abnormal_brown_adipose	0.62840287
153	MP0003656_abnormal_erythrocyte_physiolo	0.62440577
154	MP0002928_abnormal_bile_duct	0.62392307
155	MP0001502_abnormal_circadian_rhythm	0.60617715
156	MP0005187_abnormal_penis_morphology	0.59586587
157	MP0000598_abnormal_liver_morphology	0.59214341
158	MP0002069_abnormal_eating/drinking_beha	0.59051473
159	MP0001486_abnormal_startle_reflex	0.58128591
160	MP0005451_abnormal_body_composition	0.57731330
161	MP0005448_abnormal_energy_balance	0.57491179
162	MP0000639_abnormal_adrenal_gland	0.57209401
163	MP0005376_homeostasis/metabolism_phenot	0.56753700
164	MP0005595_abnormal_vascular_smooth	0.55527382
165	MP0002254_reproductive_system_inflammat	0.55037414
166	MP0004142_abnormal_muscle_tone	0.53701451
167	MP0002735_abnormal_chemical_nociception	0.53376533

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	7.44651552
2	Abnormal respiratory motile cilium morphology (HP:0005938)	6.93637998
3	Abnormal respiratory epithelium morphology (HP:0012253)	6.93637998
4	Abnormal respiratory motile cilium physiology (HP:0012261)	6.56174411
5	Abnormal ciliary motility (HP:0012262)	6.42235124
6	Absent/shortened dynein arms (HP:0200106)	6.42078475
7	Dynein arm defect of respiratory motile cilia (HP:0012255)	6.42078475
8	Abnormality of aromatic amino acid family metabolism (HP:0004338)	6.16980660
9	Rhinitis (HP:0012384)	5.93395487
10	Nasal polyposis (HP:0100582)	5.72186570
11	Deep venous thrombosis (HP:0002625)	5.47487006
12	Abnormality of monocarboxylic acid metabolism (HP:0010996)	5.06515900
13	Bronchiectasis (HP:0002110)	5.04831532
14	Abnormality of the nasal mucosa (HP:0000433)	5.03056819
15	Intrahepatic cholestasis (HP:0001406)	4.61950210
16	Hyperactive renin-angiotensin system (HP:0000841)	4.54468221
17	Hemorrhage of the eye (HP:0011885)	4.48342250
18	Xanthomatosis (HP:0000991)	4.45223172
19	Hyperlipoproteinemia (HP:0010980)	4.38945309
20	Hypobetalipoproteinemia (HP:0003563)	4.35441788
21	Prolonged partial thromboplastin time (HP:0003645)	4.34296501
22	Recurrent sinusitis (HP:0011108)	4.19619267
23	Delayed CNS myelination (HP:0002188)	4.08095811
24	Ketosis (HP:0001946)	3.81490195
25	Testicular atrophy (HP:0000029)	3.70247485
26	Conjugated hyperbilirubinemia (HP:0002908)	3.65504119
27	Hypokalemic alkalosis (HP:0001949)	3.64065729
28	Recurrent otitis media (HP:0000403)	3.45459100
29	Bronchitis (HP:0012387)	3.44666395
30	Chronic bronchitis (HP:0004469)	3.44155612
31	Gout (HP:0001997)	3.43853938
32	Ketoacidosis (HP:0001993)	3.40900842
33	Hyperammonemia (HP:0001987)	3.37325594
34	Hyperglycinuria (HP:0003108)	3.37251794
35	Goiter (HP:0000853)	3.32123419
36	Alkalosis (HP:0001948)	3.31202630
37	Chronic sinusitis (HP:0011109)	3.24719961
38	Hyperglycinemia (HP:0002154)	3.21830466
39	Hyperaldosteronism (HP:0000859)	3.20133133
40	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.17674219
41	Hypolipoproteinemia (HP:0010981)	3.17364749
42	Joint hemorrhage (HP:0005261)	3.09363237
43	Thin bony cortex (HP:0002753)	3.08765168
44	Male infertility (HP:0003251)	3.01321277
45	Abnormality of glycine metabolism (HP:0010895)	2.99185655
46	Abnormality of serine family amino acid metabolism (HP:0010894)	2.99185655
47	Complement deficiency (HP:0004431)	2.97665354
48	Atelectasis (HP:0100750)	2.94430925
49	Infertility (HP:0000789)	2.90935386
50	Metabolic acidosis (HP:0001942)	2.90384292
51	Abnormality of the common coagulation pathway (HP:0010990)	2.90266898
52	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.85715180
53	Hypoalphalipoproteinemia (HP:0003233)	2.83319312
54	Hypoglycemic coma (HP:0001325)	2.82679979
55	Renal salt wasting (HP:0000127)	2.81507502
56	Hyperbilirubinemia (HP:0002904)	2.78945477
57	Chronic otitis media (HP:0000389)	2.77401280
58	Annular pancreas (HP:0001734)	2.73284560
59	Epidermoid cyst (HP:0200040)	2.73269853
60	Decreased circulating renin level (HP:0003351)	2.72213550
61	Fat malabsorption (HP:0002630)	2.69151279
62	Recurrent bronchitis (HP:0002837)	2.67840546
63	Vascular calcification (HP:0004934)	2.65825234
64	Status epilepticus (HP:0002133)	2.65192816
65	Abnormality of the intrinsic pathway (HP:0010989)	2.63038592
66	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.61002546
67	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.56198725
68	Mesangial abnormality (HP:0001966)	2.55455948
69	Abnormality of purine metabolism (HP:0004352)	2.54991863
70	Abnormality of fatty-acid metabolism (HP:0004359)	2.52526251
71	Vaginal fistula (HP:0004320)	2.51189166
72	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.50024160
73	Glomerulonephritis (HP:0000099)	2.48704004
74	Aplasia of the musculature (HP:0100854)	2.46358100
75	Abnormality of chloride homeostasis (HP:0011422)	2.43806791
76	Hypercholesterolemia (HP:0003124)	2.41012185
77	Neonatal onset (HP:0003623)	2.40559468
78	Abnormality of nucleobase metabolism (HP:0010932)	2.37984182
79	Thyroid-stimulating hormone excess (HP:0002925)	2.35210299
80	Abnormality of renin-angiotensin system (HP:0000847)	2.34742905
81	Late onset (HP:0003584)	2.34141272
82	Cardiovascular calcification (HP:0011915)	2.29581143
83	Systemic lupus erythematosus (HP:0002725)	2.28704647
84	Obstructive sleep apnea (HP:0002870)	2.28136311
85	Visual hallucinations (HP:0002367)	2.24918117
86	Pili torti (HP:0003777)	2.24770008
87	Popliteal pterygium (HP:0009756)	2.22923998
88	Sensorimotor neuropathy (HP:0007141)	2.19728597
89	Hyperkalemia (HP:0002153)	2.19643809
90	Action tremor (HP:0002345)	2.19567856
91	Abnormality of methionine metabolism (HP:0010901)	2.19341854
92	Spontaneous abortion (HP:0005268)	2.18704270
93	Purpura (HP:0000979)	2.18244759
94	Irritability (HP:0000737)	2.16321972
95	Esophageal varix (HP:0002040)	2.16072618
96	Ulnar bowing (HP:0003031)	2.15656827
97	Confusion (HP:0001289)	2.15000807
98	Abnormality of the lower motor neuron (HP:0002366)	2.14119484
99	Gastrointestinal stroma tumor (HP:0100723)	2.08724524
100	Emphysema (HP:0002097)	2.08702603
101	Amyloidosis (HP:0011034)	2.05043336
102	Spastic diplegia (HP:0001264)	2.05039945
103	Hepatocellular carcinoma (HP:0001402)	2.04902524
104	Focal dystonia (HP:0004373)	2.04053854
105	Abnormality of pyrimidine metabolism (HP:0004353)	2.03968820
106	Nephritis (HP:0000123)	2.03891061
107	Occipital encephalocele (HP:0002085)	2.02821544
108	Abnormality of complement system (HP:0005339)	2.01765033
109	Craniofacial dystonia (HP:0012179)	2.00928283
110	Hypoglycemic seizures (HP:0002173)	2.00156526
111	Decreased central vision (HP:0007663)	1.99510238
112	Hypochromic microcytic anemia (HP:0004840)	1.99150974
113	Dyschromatopsia (HP:0007641)	1.98705820
114	Torticollis (HP:0000473)	1.98047639
115	Abnormality of sodium homeostasis (HP:0010931)	1.97431282
116	Atrioventricular block (HP:0001678)	1.97096385
117	Increased purine levels (HP:0004368)	1.97060000
118	Hyperuricemia (HP:0002149)	1.97060000
119	Focal motor seizures (HP:0011153)	1.96874150
120	Rib fusion (HP:0000902)	1.96803082
121	Myokymia (HP:0002411)	1.96327295
122	Lethargy (HP:0001254)	1.94680059
123	Poikilocytosis (HP:0004447)	1.94399655
124	Fetal akinesia sequence (HP:0001989)	1.93406236
125	Steatorrhea (HP:0002570)	1.93218431
126	Epistaxis (HP:0000421)	1.92924078
127	Intestinal fistula (HP:0100819)	1.91817517
128	Mucopolysacchariduria (HP:0008155)	1.90533171
129	Urinary glycosaminoglycan excretion (HP:0003541)	1.90533171
130	Abnormal hair laboratory examination (HP:0003328)	1.89735417
131	Cholelithiasis (HP:0001081)	1.89715282
132	Tetany (HP:0001281)	1.89666329
133	Abnormality of serum amino acid levels (HP:0003112)	1.89657565
134	Abnormal gallbladder morphology (HP:0012437)	1.89384772
135	Renal tubular acidosis (HP:0001947)	1.88000729
136	Menorrhagia (HP:0000132)	1.87820391
137	Turricephaly (HP:0000262)	1.87496610
138	Vomiting (HP:0002013)	1.85674204
139	Death in childhood (HP:0003819)	1.85105824
140	Joint stiffness (HP:0001387)	1.84798897
141	Recurrent gram-negative bacterial infections (HP:0005420)	1.84120253
142	Malnutrition (HP:0004395)	1.84114996
143	Nephrolithiasis (HP:0000787)	1.84059469
144	Tetraplegia (HP:0002445)	1.84022314
145	Polycythemia (HP:0001901)	1.83721063
146	Metabolic alkalosis (HP:0200114)	1.83459124
147	Cholecystitis (HP:0001082)	1.82850135
148	Abnormal gallbladder physiology (HP:0012438)	1.82850135
149	Rectovaginal fistula (HP:0000143)	1.82666326
150	Rectal fistula (HP:0100590)	1.82666326
151	Colitis (HP:0002583)	1.82449520
152	Hypertriglyceridemia (HP:0002155)	1.80991286
153	Hyponatremia (HP:0002902)	1.80842185
154	Abnormality of polysaccharide metabolism (HP:0011012)	1.80274968
155	Abnormality of glycosaminoglycan metabolism (HP:0004371)	1.80274968
156	Abnormality of mucopolysaccharide metabolism (HP:0011020)	1.80274968
157	Brushfield spots (HP:0001088)	1.79637522
158	Adrenal overactivity (HP:0002717)	1.78323239
159	Eczematoid dermatitis (HP:0000976)	1.77929158
160	Anteriorly placed anus (HP:0001545)	1.72436930
161	Stridor (HP:0010307)	1.70327349
162	Gastrointestinal infarctions (HP:0005244)	1.69150540
163	Increased serum ferritin (HP:0003281)	1.67621680
164	Hypophosphatemic rickets (HP:0004912)	1.66497121
165	Cervical subluxation (HP:0003308)	1.66474584
166	Poikiloderma (HP:0001029)	1.62043824
167	Attenuation of retinal blood vessels (HP:0007843)	1.58119248
168	Myopathic facies (HP:0002058)	1.56707840
169	Rickets (HP:0002748)	1.56121657
170	Increased IgE level (HP:0003212)	1.55860177
171	Increased muscle lipid content (HP:0009058)	1.53116609
172	Abnormality of the radial head (HP:0003995)	1.52108170
173	Polygenic inheritance (HP:0010982)	1.51597972
174	Dislocated radial head (HP:0003083)	1.49448771
175	Hyperinsulinemic hypoglycemia (HP:0000825)	1.46820648
176	Widely patent fontanelles and sutures (HP:0004492)	1.44846007
177	Hypoalbuminemia (HP:0003073)	1.44796948
178	Abnormal albumin level (HP:0012116)	1.44796948
179	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.41842916
180	Myositis (HP:0100614)	1.41515188
181	Meningitis (HP:0001287)	1.41368262
182	Gastrointestinal inflammation (HP:0004386)	1.39903150

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPK15	3.61160623
2	BCKDK	3.53862410
3	DAPK2	3.06036329
4	CAMKK2	2.96252395
5	SMG1	2.78597371
6	RIPK1	2.57330340
7	MAP2K4	2.53013876
8	MAP4K1	2.51243642
9	RIPK4	2.47195508
10	ERN1	2.36444387
11	NTRK3	2.24801677
12	SIK1	2.03846710
13	CAMKK1	2.00508793
14	TBK1	1.94817689
15	LMTK2	1.78889972
16	EPHA2	1.78357672
17	GRK6	1.77896447
18	PRPF4B	1.76573244
19	BLK	1.73592998
20	MAP3K4	1.73146402
21	TAOK1	1.72767175
22	ERBB3	1.70453393
23	STK38	1.67128777
24	PINK1	1.64360897
25	FLT3	1.62962222
26	NME1	1.59478209
27	CSK	1.58288436
28	MAP3K9	1.56673975
29	TNIK	1.55439827
30	TRIB3	1.55211254
31	EPHA4	1.49191884
32	MAP3K2	1.44105392
33	TYK2	1.43865533
34	MINK1	1.43481807
35	ZAP70	1.40005014
36	MAP2K7	1.38813988
37	STK16	1.36833608
38	MAP2K3	1.34276524
39	DAPK1	1.31726355
40	KDR	1.30872257
41	MAPKAPK3	1.27628528
42	STK24	1.27526852
43	INSRR	1.27322001
44	MAP3K13	1.26032237
45	PIM2	1.25299111
46	CAMK2G	1.21972327
47	MST4	1.20463517
48	ICK	1.19893307
49	LRRK2	1.17755446
50	PASK	1.17726493
51	MAP3K6	1.16190682
52	FRK	1.15505283
53	PRKCG	1.14584509
54	CAMK2B	1.14534599
55	CAMK1	1.14353866
56	CDK19	1.13942075
57	TNK2	1.11957606
58	PAK3	1.11396294
59	BTK	1.10935529
60	MAP3K3	1.09856324
61	FGFR4	1.09471069
62	CAMK4	1.09405599
63	FER	1.08373830
64	MAP3K10	1.07281566
65	PTK2	1.05077344
66	CAMK1G	1.04623334
67	CAMK1D	1.03176060
68	PRKD2	0.98869715
69	CAMK2D	0.98488477
70	TLK1	0.97757797
71	MAP3K7	0.96610984
72	NTRK2	0.96174456
73	MAP2K6	0.95949622
74	TESK1	0.95018004
75	PTK6	0.93518422
76	PIK3CG	0.92621280
77	PRKG2	0.91251240
78	KSR2	0.89319122
79	PAK6	0.87722464
80	CDK4	0.87658809
81	TIE1	0.87238650
82	IKBKE	0.87090784
83	OXSR1	0.86523126
84	TXK	0.86467494
85	CDC42BPA	0.85870374
86	EEF2K	0.84824512
87	WNK4	0.82482089
88	TAOK3	0.82260586
89	PHKG1	0.79963860
90	PHKG2	0.79963860
91	SGK223	0.79742001
92	SGK494	0.79742001
93	DYRK1B	0.79697044
94	SGK3	0.78831993
95	MAPK7	0.78748637
96	TEC	0.78028873
97	MAP3K1	0.76624747
98	RET	0.73155038
99	NTRK1	0.72239742
100	MAP2K2	0.72045769
101	PRKCQ	0.72011632
102	PDPK1	0.70975449
103	HIPK2	0.70255754
104	JAK1	0.68345521
105	MAP3K14	0.67973319
106	SYK	0.66600736
107	SIK2	0.64802045
108	SGK2	0.64767223
109	BMPR2	0.64535688
110	IRAK4	0.63900148
111	CAMK2A	0.63787416
112	HCK	0.63622001
113	PKN2	0.61580133
114	PRKCZ	0.61207028
115	CDK5	0.61191620
116	ARAF	0.60814656
117	JAK3	0.60484396
118	FES	0.60425981
119	MST1R	0.60264278
120	IKBKB	0.60261941
121	MARK2	0.59791971
122	RPS6KL1	0.59065585
123	RPS6KC1	0.59065585
124	UHMK1	0.59045341
125	WNK3	0.58338399
126	PRKD3	0.57992545
127	MAP2K1	0.57219632
128	LYN	0.56371263
129	ITK	0.56314300
130	PRKCH	0.55118516
131	CSNK1G2	0.52752521
132	FGFR2	0.52519557
133	TESK2	0.51768599
134	RPS6KA2	0.51723383
135	MAP3K11	0.51718851
136	FGFR3	0.51140195
137	MAPK11	0.50107741
138	PRKAA2	0.49965712
139	BMX	0.49626607
140	MUSK	0.49223744
141	DAPK3	0.48524092
142	RPS6KA6	0.47683604
143	TAOK2	0.46975893
144	ILK	0.46503106
145	STK11	0.46460939
146	WNK1	0.43701085
147	PRKACG	0.43104874
148	MAPK12	0.42835329
149	PRKAA1	0.42111280
150	PDK1	0.41979833
151	PTK2B	0.41943590
152	EPHB1	0.41268082
153	ERBB2	0.41163055
154	LCK	0.40938656
155	CHUK	0.40170297
156	CDK12	0.40108811
157	SIK3	0.39714080
158	PRKD1	0.38025328
159	NLK	0.37164666
160	STK10	0.36005531
161	TRPM7	0.35741266
162	RPS6KA5	0.34756501

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.73859719
2	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.44073855
3	Nitrogen metabolism_Homo sapiens_hsa00910	2.92808238
4	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.69394992
5	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.61026933
6	Arginine biosynthesis_Homo sapiens_hsa00220	2.59147262
7	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.41891021
8	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.30160933
9	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.23855205
10	Chemical carcinogenesis_Homo sapiens_hsa05204	2.18455739
11	Fatty acid degradation_Homo sapiens_hsa00071	2.17444090
12	Tryptophan metabolism_Homo sapiens_hsa00380	2.12679119
13	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.12441411
14	Bile secretion_Homo sapiens_hsa04976	2.08607082
15	Butanoate metabolism_Homo sapiens_hsa00650	2.08341693
16	Primary immunodeficiency_Homo sapiens_hsa05340	1.98400113
17	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.94553988
18	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.87561122
19	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.85232269
20	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.80655937
21	beta-Alanine metabolism_Homo sapiens_hsa00410	1.76495135
22	Olfactory transduction_Homo sapiens_hsa04740	1.74356737
23	Peroxisome_Homo sapiens_hsa04146	1.73080229
24	Complement and coagulation cascades_Homo sapiens_hsa04610	1.71781376
25	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.70153249
26	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.69972346
27	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.69476556
28	Histidine metabolism_Homo sapiens_hsa00340	1.65878759
29	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.65062748
30	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.63166462
31	Retinol metabolism_Homo sapiens_hsa00830	1.61736738
32	Caffeine metabolism_Homo sapiens_hsa00232	1.58664442
33	Sulfur metabolism_Homo sapiens_hsa00920	1.57504261
34	Other glycan degradation_Homo sapiens_hsa00511	1.56772727
35	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.48854614
36	Propanoate metabolism_Homo sapiens_hsa00640	1.45392698
37	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.43739215
38	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.42669044
39	Tyrosine metabolism_Homo sapiens_hsa00350	1.40604019
40	PPAR signaling pathway_Homo sapiens_hsa03320	1.38347963
41	Allograft rejection_Homo sapiens_hsa05330	1.34072338
42	Fatty acid metabolism_Homo sapiens_hsa01212	1.32481853
43	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.26488841
44	Graft-versus-host disease_Homo sapiens_hsa05332	1.25829172
45	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.24230560
46	ABC transporters_Homo sapiens_hsa02010	1.23853643
47	Pyruvate metabolism_Homo sapiens_hsa00620	1.20597526
48	Phenylalanine metabolism_Homo sapiens_hsa00360	1.20306011
49	Thyroid hormone synthesis_Homo sapiens_hsa04918	1.19530585
50	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.18477365
51	Sulfur relay system_Homo sapiens_hsa04122	1.12407727
52	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.09331777
53	Nicotine addiction_Homo sapiens_hsa05033	1.04470533
54	Sphingolipid metabolism_Homo sapiens_hsa00600	1.04149125
55	Selenocompound metabolism_Homo sapiens_hsa00450	1.02003490
56	Notch signaling pathway_Homo sapiens_hsa04330	1.01664209
57	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.01143530
58	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.96836753
59	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.96404171
60	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.95854414
61	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.95722173
62	Taste transduction_Homo sapiens_hsa04742	0.92195041
63	GABAergic synapse_Homo sapiens_hsa04727	0.91932079
64	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.91857270
65	Type I diabetes mellitus_Homo sapiens_hsa04940	0.87848288
66	Glutathione metabolism_Homo sapiens_hsa00480	0.84619847
67	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.83976049
68	Hepatitis C_Homo sapiens_hsa05160	0.81132686
69	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.78745484
70	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.78685307
71	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.78150489
72	Arginine and proline metabolism_Homo sapiens_hsa00330	0.76646946
73	Folate biosynthesis_Homo sapiens_hsa00790	0.76138144
74	Circadian rhythm_Homo sapiens_hsa04710	0.75707573
75	Gastric acid secretion_Homo sapiens_hsa04971	0.75576520
76	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.74422636
77	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.73964496
78	Carbon metabolism_Homo sapiens_hsa01200	0.73354903
79	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.73056871
80	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.72392066
81	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.71414258
82	Glycerolipid metabolism_Homo sapiens_hsa00561	0.70178730
83	Circadian entrainment_Homo sapiens_hsa04713	0.69157347
84	Glutamatergic synapse_Homo sapiens_hsa04724	0.67584791
85	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.65034960
86	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.64561343
87	Salivary secretion_Homo sapiens_hsa04970	0.64246972
88	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.63483494
89	Insulin secretion_Homo sapiens_hsa04911	0.63016371
90	Acute myeloid leukemia_Homo sapiens_hsa05221	0.62552654
91	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.61688216
92	Fatty acid elongation_Homo sapiens_hsa00062	0.61200013
93	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.61089829
94	Galactose metabolism_Homo sapiens_hsa00052	0.59754490
95	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.55413412
96	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.55008487
97	Fat digestion and absorption_Homo sapiens_hsa04975	0.54631124
98	Morphine addiction_Homo sapiens_hsa05032	0.54506321
99	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.53745287
100	Amphetamine addiction_Homo sapiens_hsa05031	0.52118885
101	Antigen processing and presentation_Homo sapiens_hsa04612	0.51243594
102	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.51057795
103	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.49290154
104	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.48940456
105	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.47942592
106	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.47669575
107	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.47585255
108	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.46850796
109	Long-term potentiation_Homo sapiens_hsa04720	0.46145168
110	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.45095710
111	Lysine degradation_Homo sapiens_hsa00310	0.44590533
112	Leishmaniasis_Homo sapiens_hsa05140	0.43085776
113	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.42154922
114	Linoleic acid metabolism_Homo sapiens_hsa00591	0.41396147
115	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.41020859
116	Pertussis_Homo sapiens_hsa05133	0.40922719
117	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.40667414
118	Herpes simplex infection_Homo sapiens_hsa05168	0.40432942
119	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.35693984
120	Tuberculosis_Homo sapiens_hsa05152	0.35109435
121	Mineral absorption_Homo sapiens_hsa04978	0.35014077
122	VEGF signaling pathway_Homo sapiens_hsa04370	0.34904105
123	Viral myocarditis_Homo sapiens_hsa05416	0.34123204
124	Lysosome_Homo sapiens_hsa04142	0.33373394
125	Dopaminergic synapse_Homo sapiens_hsa04728	0.33193002
126	Endocytosis_Homo sapiens_hsa04144	0.32621630
127	Insulin signaling pathway_Homo sapiens_hsa04910	0.31290644
128	Asthma_Homo sapiens_hsa05310	0.30712743
129	cAMP signaling pathway_Homo sapiens_hsa04024	0.30348687
130	Influenza A_Homo sapiens_hsa05164	0.30315615
131	Osteoclast differentiation_Homo sapiens_hsa04380	0.29663250
132	Cocaine addiction_Homo sapiens_hsa05030	0.29271465
133	Glucagon signaling pathway_Homo sapiens_hsa04922	0.29123617
134	Collecting duct acid secretion_Homo sapiens_hsa04966	0.28978806
135	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.28920236
136	Toxoplasmosis_Homo sapiens_hsa05145	0.28726528
137	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.28075242
138	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.26903079
139	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.25775086
140	Metabolic pathways_Homo sapiens_hsa01100	0.25725226
141	Type II diabetes mellitus_Homo sapiens_hsa04930	0.23997917
142	Pentose phosphate pathway_Homo sapiens_hsa00030	0.23279363
143	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.21152279
144	Prion diseases_Homo sapiens_hsa05020	0.19117932
145	Long-term depression_Homo sapiens_hsa04730	0.17561273
146	Insulin resistance_Homo sapiens_hsa04931	0.16485583
147	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.16350729
148	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.16287901
149	Cholinergic synapse_Homo sapiens_hsa04725	0.15991304
150	Vibrio cholerae infection_Homo sapiens_hsa05110	0.15356907

SLC16A11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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