SLC16A13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of fibrinolysis (GO:0051918)7.27318999
2regulation of fibrinolysis (GO:0051917)6.66965186
3peptidyl-glutamic acid carboxylation (GO:0017187)5.86748647
4protein carboxylation (GO:0018214)5.86748647
5L-phenylalanine metabolic process (GO:0006558)5.40829107
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.40829107
7regulation of protein activation cascade (GO:2000257)5.18829242
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.18655337
9L-phenylalanine catabolic process (GO:0006559)5.18655337
10negative regulation of sterol transport (GO:0032372)5.17803040
11negative regulation of cholesterol transport (GO:0032375)5.17803040
12fibrinolysis (GO:0042730)5.16086639
13aminoglycoside antibiotic metabolic process (GO:0030647)4.97350430
14very-low-density lipoprotein particle assembly (GO:0034379)4.96424499
15regulation of complement activation (GO:0030449)4.91092264
16urate metabolic process (GO:0046415)4.78073515
17urea metabolic process (GO:0019627)4.67823761
18regulation of plasminogen activation (GO:0010755)4.58651925
19complement activation, alternative pathway (GO:0006957)4.52437800
20DNA unwinding involved in DNA replication (GO:0006268)4.51530745
21intestinal cholesterol absorption (GO:0030299)4.41494287
22phospholipid efflux (GO:0033700)4.35573712
23blood coagulation, intrinsic pathway (GO:0007597)4.34661232
24exogenous drug catabolic process (GO:0042738)4.31900523
25plasma lipoprotein particle assembly (GO:0034377)4.28625019
26nitrogen cycle metabolic process (GO:0071941)4.25477658
27ribosomal small subunit assembly (GO:0000028)4.22372453
28urea cycle (GO:0000050)4.21659465
29drug transport (GO:0015893)4.14926869
30drug transmembrane transport (GO:0006855)4.12595202
31regulation of cholesterol esterification (GO:0010872)4.07390412
32viral transcription (GO:0019083)4.05688804
33DNA strand elongation involved in DNA replication (GO:0006271)4.05627278
34epoxygenase P450 pathway (GO:0019373)4.04663494
35cholesterol efflux (GO:0033344)3.99353413
36drug catabolic process (GO:0042737)3.98957686
37negative regulation of hemostasis (GO:1900047)3.93132046
38negative regulation of blood coagulation (GO:0030195)3.93132046
39translational termination (GO:0006415)3.93084029
40daunorubicin metabolic process (GO:0044597)3.91624113
41polyketide metabolic process (GO:0030638)3.91624113
42doxorubicin metabolic process (GO:0044598)3.91624113
43protein-lipid complex assembly (GO:0065005)3.83068729
44DNA strand elongation (GO:0022616)3.82931170
45DNA deamination (GO:0045006)3.76518968
46translational elongation (GO:0006414)3.76099677
47folic acid metabolic process (GO:0046655)3.72425845
48alpha-linolenic acid metabolic process (GO:0036109)3.71478896
49formation of translation preinitiation complex (GO:0001731)3.70604500
50cellular glucuronidation (GO:0052695)3.69016290
51plasma lipoprotein particle clearance (GO:0034381)3.68694235
52positive regulation of extracellular matrix organization (GO:1903055)3.66778243
53omega-hydroxylase P450 pathway (GO:0097267)3.65641339
54regulation of cholesterol homeostasis (GO:2000188)3.65362869
55positive regulation of blood coagulation (GO:0030194)3.62446483
56positive regulation of hemostasis (GO:1900048)3.62446483
57maturation of SSU-rRNA (GO:0030490)3.60549589
58triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.59442125
59plasma lipoprotein particle remodeling (GO:0034369)3.57896916
60protein-lipid complex remodeling (GO:0034368)3.57896916
61macromolecular complex remodeling (GO:0034367)3.57896916
62regulation of apoptotic cell clearance (GO:2000425)3.57202009
63high-density lipoprotein particle remodeling (GO:0034375)3.56786684
64negative regulation of coagulation (GO:0050819)3.56684187
65acute-phase response (GO:0006953)3.55796370
66translational initiation (GO:0006413)3.54098473
67telomere maintenance via semi-conservative replication (GO:0032201)3.52317571
68positive regulation of lipoprotein lipase activity (GO:0051006)3.51019627
69positive regulation of triglyceride lipase activity (GO:0061365)3.51019627
70negative regulation of fatty acid biosynthetic process (GO:0045717)3.48308338
71organic cation transport (GO:0015695)3.47173284
72regulation of lipoprotein particle clearance (GO:0010984)3.45074812
73proline biosynthetic process (GO:0006561)3.44323479
74glucuronate metabolic process (GO:0019585)3.43721004
75uronic acid metabolic process (GO:0006063)3.43721004
76negative regulation of wound healing (GO:0061045)3.42633415
77SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.40466001
78fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.39323965
79positive regulation of coagulation (GO:0050820)3.37989234
80Golgi transport vesicle coating (GO:0048200)3.33292561
81COPI coating of Golgi vesicle (GO:0048205)3.33292561
82DNA replication initiation (GO:0006270)3.32873925
83cotranslational protein targeting to membrane (GO:0006613)3.30984345
84tricarboxylic acid metabolic process (GO:0072350)3.29698598
85regulation of humoral immune response (GO:0002920)3.29599987
86protein targeting to ER (GO:0045047)3.29283583
87glycine metabolic process (GO:0006544)3.27156975
88nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.26894833
89dosage compensation (GO:0007549)3.23705430
90plasma lipoprotein particle organization (GO:0071827)3.22617914
91regulation of cholesterol biosynthetic process (GO:0045540)3.22341440
92toxin transport (GO:1901998)3.22323452
93nucleobase biosynthetic process (GO:0046112)3.20566820
94negative regulation of lipase activity (GO:0060192)3.19129765
95regulation of triglyceride catabolic process (GO:0010896)3.15731891
96viral life cycle (GO:0019058)3.14082536
97folic acid-containing compound biosynthetic process (GO:0009396)3.12655513
98negative regulation of lipid transport (GO:0032369)3.12524841
99ethanol oxidation (GO:0006069)3.12022633
100acylglycerol homeostasis (GO:0055090)3.11941876
101triglyceride homeostasis (GO:0070328)3.11941876
102protein localization to kinetochore (GO:0034501)3.10961604
103bile acid metabolic process (GO:0008206)3.10887239
104establishment of protein localization to endoplasmic reticulum (GO:0072599)3.09709283
105ribosomal small subunit biogenesis (GO:0042274)3.08079661
106protein localization to endoplasmic reticulum (GO:0070972)3.06874412
107primary alcohol catabolic process (GO:0034310)3.06784302
108reverse cholesterol transport (GO:0043691)3.06305768
109protein activation cascade (GO:0072376)3.06061250
110serine family amino acid catabolic process (GO:0009071)3.05660727
111cellular protein complex disassembly (GO:0043624)3.04545502
112protein-lipid complex subunit organization (GO:0071825)3.04193701
113pentose-phosphate shunt (GO:0006098)3.02583959
114positive regulation of fatty acid biosynthetic process (GO:0045723)3.02253609
115bile acid biosynthetic process (GO:0006699)3.01689912
116phosphate ion transport (GO:0006817)3.01067026
117aromatic amino acid family catabolic process (GO:0009074)2.99724401
118pseudouridine synthesis (GO:0001522)2.97996022
119glutamate metabolic process (GO:0006536)2.96212706
120modified amino acid transport (GO:0072337)2.95350052
121NADPH regeneration (GO:0006740)2.91468538
122lysine metabolic process (GO:0006553)2.91160678
123lysine catabolic process (GO:0006554)2.91160678
124telomere maintenance via telomere lengthening (GO:0010833)2.91054921
125glucose 6-phosphate metabolic process (GO:0051156)2.90873453
126DNA replication checkpoint (GO:0000076)2.89614760
127regulation of cholesterol metabolic process (GO:0090181)2.89524562
128ribosomal large subunit biogenesis (GO:0042273)2.88809748
129fat-soluble vitamin biosynthetic process (GO:0042362)2.88461448
130protein complex disassembly (GO:0043241)2.88293944
131telomere maintenance via recombination (GO:0000722)2.88191782
132ethanol metabolic process (GO:0006067)2.86792385
133drug metabolic process (GO:0017144)2.86775937
134ribosome assembly (GO:0042255)2.85439311
135IMP biosynthetic process (GO:0006188)2.85202503
136cytolysis (GO:0019835)2.83846103
137amino-acid betaine metabolic process (GO:0006577)2.80528132
138mitotic recombination (GO:0006312)2.80521944
139phenylpropanoid metabolic process (GO:0009698)2.80517377
140mitotic nuclear envelope disassembly (GO:0007077)2.80366453
141ribonucleoprotein complex biogenesis (GO:0022613)2.77936215
142purine nucleobase biosynthetic process (GO:0009113)2.76456608
143regulation of extracellular matrix organization (GO:1903053)2.73591598
144positive regulation of cellular amine metabolic process (GO:0033240)2.73379926
145IMP metabolic process (GO:0046040)2.73364861
146low-density lipoprotein particle remodeling (GO:0034374)2.72343452
147ribosome biogenesis (GO:0042254)2.71396739
148negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.71185126
149complement activation, classical pathway (GO:0006958)2.70684921
150regulation of fatty acid biosynthetic process (GO:0042304)2.70160057
151mitotic metaphase plate congression (GO:0007080)2.69483689
152rRNA processing (GO:0006364)2.68583542
153peptide catabolic process (GO:0043171)2.67706374
154macromolecular complex disassembly (GO:0032984)2.65880606
1553-UTR-mediated mRNA stabilization (GO:0070935)2.64465703
156nucleotide-excision repair, DNA gap filling (GO:0006297)2.64144066
157nuclear envelope disassembly (GO:0051081)2.62948326
158membrane disassembly (GO:0030397)2.62948326
159protein localization to chromosome, centromeric region (GO:0071459)2.61002887
160negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.59987811
161metaphase plate congression (GO:0051310)2.59876134
162rRNA metabolic process (GO:0016072)2.59305795
163nuclear-transcribed mRNA catabolic process (GO:0000956)2.57624653
164anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.57619232
165quaternary ammonium group transport (GO:0015697)2.57239098
166negative regulation of RNA splicing (GO:0033119)2.56793907
167regulation of apoptotic process involved in morphogenesis (GO:1902337)2.56287572
168regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.55757666
169folic acid-containing compound metabolic process (GO:0006760)2.55262890
170folic acid transport (GO:0015884)2.54843749
171proline metabolic process (GO:0006560)2.54075767
172translation (GO:0006412)2.51891253
173galactose catabolic process (GO:0019388)2.50489822
174pteridine-containing compound biosynthetic process (GO:0042559)2.50414881
175serine family amino acid biosynthetic process (GO:0009070)2.47406148
176establishment of integrated proviral latency (GO:0075713)2.46941994
177renal absorption (GO:0070293)2.46921644
178glyoxylate metabolic process (GO:0046487)2.46115095
179regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.46094968
180mitotic chromosome condensation (GO:0007076)2.45142347
181mRNA catabolic process (GO:0006402)2.44990378
182RNA catabolic process (GO:0006401)2.44884430
183deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.44467307
184positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.44065084
185platelet dense granule organization (GO:0060155)2.43811600
186pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.43175251
187regulation of translational fidelity (GO:0006450)2.40554048
188base-excision repair, AP site formation (GO:0006285)2.39822373
189glycoside metabolic process (GO:0016137)2.39244720
190endothelium development (GO:0003158)2.38952548
191excretion (GO:0007588)2.37650938
192negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.37405230
193negative regulation of ligase activity (GO:0051352)2.37405230
194phosphate ion transmembrane transport (GO:0035435)2.36862650
195serine family amino acid metabolic process (GO:0009069)2.36718726

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.92234078
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.74652424
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.90545129
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.71488460
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.12079118
6* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.97011721
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.71126372
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.53768299
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.52884211
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.42931904
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.41344668
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.38533128
13ZNF263_19887448_ChIP-Seq_K562_Human2.36154763
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.36059556
15AR_21909140_ChIP-Seq_LNCAP_Human2.33826181
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.33700549
17MYC_22102868_ChIP-Seq_BL_Human2.31340150
18XRN2_22483619_ChIP-Seq_HELA_Human2.30251222
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.28340050
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.26726684
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.22193140
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.17606368
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.05455218
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.01762260
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.01071717
26LXR_22158963_ChIP-Seq_LIVER_Mouse2.00828682
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.95561312
28VDR_21846776_ChIP-Seq_THP-1_Human1.92972516
29FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.92539439
30E2F1_18555785_ChIP-Seq_MESCs_Mouse1.90614140
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.89958339
32CIITA_25753668_ChIP-Seq_RAJI_Human1.88673538
33EGR1_23403033_ChIP-Seq_LIVER_Mouse1.88544818
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.87498111
35* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85814481
36RACK7_27058665_Chip-Seq_MCF-7_Human1.85805526
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.83802156
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.83205176
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.82839865
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.80401587
41BP1_19119308_ChIP-ChIP_Hs578T_Human1.72014981
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.63066552
43GABP_19822575_ChIP-Seq_HepG2_Human1.62334593
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58022237
45DCP1A_22483619_ChIP-Seq_HELA_Human1.56408491
46TTF2_22483619_ChIP-Seq_HELA_Human1.55472760
47EGR1_19374776_ChIP-ChIP_THP-1_Human1.55450448
48VDR_23849224_ChIP-Seq_CD4+_Human1.55440683
49SCL_19346495_ChIP-Seq_HPC-7_Human1.55356901
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.54232765
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.53250990
52NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.52114172
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46119182
54ESR1_15608294_ChIP-ChIP_MCF-7_Human1.45820909
55FOXP3_21729870_ChIP-Seq_TREG_Human1.45435293
56* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45400171
57TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44524802
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41795129
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41791525
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40701692
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.39155615
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.38970744
63RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38210244
64* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.37767403
65IRF8_22096565_ChIP-ChIP_GC-B_Human1.36646691
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35732456
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34401898
68TP63_17297297_ChIP-ChIP_HaCaT_Human1.32949166
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.31888487
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29898619
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.29278826
72* TET1_21451524_ChIP-Seq_MESCs_Mouse1.29201701
73MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29106534
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29041667
75SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.28808241
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27049229
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26765682
78THAP11_20581084_ChIP-Seq_MESCs_Mouse1.26736579
79ELF1_20517297_ChIP-Seq_JURKAT_Human1.26425749
80KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26295645
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25880120
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.25771155
83KDM2B_26808549_Chip-Seq_DND41_Human1.24811483
84BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24634906
85CLOCK_20551151_ChIP-Seq_293T_Human1.23564804
86* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23248771
87KDM5A_27292631_Chip-Seq_BREAST_Human1.22630103
88* ELK3_25401928_ChIP-Seq_HUVEC_Human1.22165506
89TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.22093133
90HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.20984180
91* TFEB_21752829_ChIP-Seq_HELA_Human1.20396051
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.19225165
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18537358
94SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18306042
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17590014
96SPI1_23547873_ChIP-Seq_NB4_Human1.16466037
97MYB_21317192_ChIP-Seq_ERMYB_Mouse1.16333481
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16299077
99YY1_21170310_ChIP-Seq_MESCs_Mouse1.16039637
100E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.15568658
101* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15134698
102CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14022819
103NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13880713
104POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.13805507
105MAF_26560356_Chip-Seq_TH2_Human1.13420691
106TCF7_22412390_ChIP-Seq_EML_Mouse1.13074597
107ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11297097
108HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.10444806
109STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08566633
110MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.08204780
111* RUNX1_22412390_ChIP-Seq_EML_Mouse1.07819614
112KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07780357
113SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07523120
114ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07234441
115* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07121298
116UTX_26944678_Chip-Seq_JUKART_Human1.06910224
117SMC4_20622854_ChIP-Seq_HELA_Human1.06812536
118* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06796735
119* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06442982
120NCOR1_26117541_ChIP-Seq_K562_Human1.05991224
121RARA_24833708_ChIP-Seq_LIVER_Mouse1.05618297
122CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04530336
123GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03233543
124DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02963408
125MAF_26560356_Chip-Seq_TH1_Human1.02915310
126BCOR_27268052_Chip-Seq_Bcells_Human1.02417892
127SA1_27219007_Chip-Seq_ERYTHROID_Human1.02323208
128SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02050446
129RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01019022
130NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00936180
131ATF3_27146783_Chip-Seq_COLON_Human1.00633396
132* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00469045
133UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00396125
134VDR_24763502_ChIP-Seq_THP-1_Human0.98420651
135* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98363927
136LXR_22292898_ChIP-Seq_THP-1_Human0.98043311
137* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97689218
138SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97207538
139BCL6_27268052_Chip-Seq_Bcells_Human0.97114726
140TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.96740449
141SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96696867
142CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95942298
143YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95808428
144FOXA2_19822575_ChIP-Seq_HepG2_Human0.95792778
145* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95766833
146SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95548582
147GATA6_25053715_ChIP-Seq_YYC3_Human0.95471469
148* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95416666
149RARB_24833708_ChIP-Seq_LIVER_Mouse0.95357920
150KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95129754
151GATA1_19941827_ChIP-Seq_MEL_Mouse0.94264602
152CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94137478
153BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92616752
154P63_26484246_Chip-Seq_KERATINOCYTES_Human0.92292762
155TP63_19390658_ChIP-ChIP_HaCaT_Human0.90675484
156* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90039919
157PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.89932066
158ELK1_19687146_ChIP-ChIP_HELA_Human0.89677166
159P68_20966046_ChIP-Seq_HELA_Human0.89657681
160PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89472620
161NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.89011602
162STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88945701
163KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88273222
164* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.87411246
165NOTCH1_21737748_ChIP-Seq_TLL_Human0.87247050

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005365_abnormal_bile_salt3.99933764
2MP0005085_abnormal_gallbladder_physiolo3.54790678
3MP0003693_abnormal_embryo_hatching3.54085419
4MP0005360_urolithiasis3.13810083
5MP0002396_abnormal_hematopoietic_system3.12921855
6MP0004957_abnormal_blastocyst_morpholog3.09687608
7MP0003111_abnormal_nucleus_morphology2.61623283
8MP0003077_abnormal_cell_cycle2.59429885
9MP0001666_abnormal_nutrient_absorption2.58906511
10MP0010094_abnormal_chromosome_stability2.56330202
11MP0003252_abnormal_bile_duct2.42345878
12MP0004019_abnormal_vitamin_homeostasis2.34684398
13MP0008007_abnormal_cellular_replicative2.29059989
14MP0003191_abnormal_cellular_cholesterol2.26362492
15MP0000490_abnormal_crypts_of2.20812108
16MP0009643_abnormal_urine_homeostasis2.19910910
17MP0010329_abnormal_lipoprotein_level1.97916962
18MP0010352_gastrointestinal_tract_polyps1.97196078
19MP0003878_abnormal_ear_physiology1.89323333
20MP0005377_hearing/vestibular/ear_phenot1.89323333
21MP0000609_abnormal_liver_physiology1.81091581
22MP0005332_abnormal_amino_acid1.80517329
23MP0002136_abnormal_kidney_physiology1.79027381
24MP0001730_embryonic_growth_arrest1.78768459
25MP0004264_abnormal_extraembryonic_tissu1.76726933
26MP0004043_abnormal_pH_regulation1.75874118
27MP0008932_abnormal_embryonic_tissue1.75496590
28MP0003868_abnormal_feces_composition1.72052159
29MP0004808_abnormal_hematopoietic_stem1.71592079
30MP0002089_abnormal_postnatal_growth/wei1.69862981
31MP0003436_decreased_susceptibility_to1.69257556
32MP0003786_premature_aging1.67137992
33MP0003315_abnormal_perineum_morphology1.65892927
34MP0010030_abnormal_orbit_morphology1.60858115
35MP0001756_abnormal_urination1.57097555
36MP0005636_abnormal_mineral_homeostasis1.54737975
37MP0008260_abnormal_autophagy1.44960687
38MP0002138_abnormal_hepatobiliary_system1.43331988
39MP0008058_abnormal_DNA_repair1.42676077
40MP0005451_abnormal_body_composition1.41554822
41MP0009840_abnormal_foam_cell1.41443466
42MP0001697_abnormal_embryo_size1.41304293
43MP0001765_abnormal_ion_homeostasis1.40533414
44MP0005076_abnormal_cell_differentiation1.39005318
45MP0000350_abnormal_cell_proliferation1.38555942
46MP0002877_abnormal_melanocyte_morpholog1.35458602
47MP0005397_hematopoietic_system_phenotyp1.35267719
48MP0001545_abnormal_hematopoietic_system1.35267719
49MP0006054_spinal_hemorrhage1.35181353
50MP0003186_abnormal_redox_activity1.30449644
51MP0003300_gastrointestinal_ulcer1.30125442
52MP0009697_abnormal_copulation1.29737692
53MP0005380_embryogenesis_phenotype1.28892447
54MP0001672_abnormal_embryogenesis/_devel1.28892447
55MP0001661_extended_life_span1.28491964
56MP0002132_abnormal_respiratory_system1.27047155
57MP0002118_abnormal_lipid_homeostasis1.26765004
58MP0010368_abnormal_lymphatic_system1.26696523
59MP0005058_abnormal_lysosome_morphology1.25232830
60MP0003984_embryonic_growth_retardation1.25079275
61MP0003718_maternal_effect1.24473148
62MP0002080_prenatal_lethality1.24204418
63MP0000685_abnormal_immune_system1.23947997
64MP0002088_abnormal_embryonic_growth/wei1.23890996
65MP0004147_increased_porphyrin_level1.21732257
66MP0002019_abnormal_tumor_incidence1.21227367
67MP0004133_heterotaxia1.21087130
68MP0005167_abnormal_blood-brain_barrier1.20039918
69MP0005319_abnormal_enzyme/_coenzyme1.19624983
70MP0000313_abnormal_cell_death1.18182836
71MP0003567_abnormal_fetal_cardiomyocyte1.15506508
72MP0002084_abnormal_developmental_patter1.15351994
73MP0005083_abnormal_biliary_tract1.14924491
74MP0000465_gastrointestinal_hemorrhage1.14069078
75MP0004947_skin_inflammation1.13123939
76MP0000689_abnormal_spleen_morphology1.13066396
77MP0009333_abnormal_splenocyte_physiolog1.12964379
78MP0001958_emphysema1.12466662
79MP0002139_abnormal_hepatobiliary_system1.11429616
80MP0003705_abnormal_hypodermis_morpholog1.10741445
81MP0003763_abnormal_thymus_physiology1.10695602
82MP0002086_abnormal_extraembryonic_tissu1.10428277
83MP0009278_abnormal_bone_marrow1.10242043
84MP0002085_abnormal_embryonic_tissue1.10222782
85MP0008469_abnormal_protein_level1.09065184
86MP0003566_abnormal_cell_adhesion1.06668999
87MP0002135_abnormal_kidney_morphology1.04718133
88MP0003943_abnormal_hepatobiliary_system1.04430511
89MP0001915_intracranial_hemorrhage1.03584336
90MP0005025_abnormal_response_to1.03518529
91MP0002722_abnormal_immune_system1.02903976
92MP0005220_abnormal_exocrine_pancreas1.02291492
93MP0008057_abnormal_DNA_replication1.02123549
94MP0000678_abnormal_parathyroid_gland1.01294441
95MP0004185_abnormal_adipocyte_glucose0.99202838
96MP0000566_synostosis0.99093401
97MP0002796_impaired_skin_barrier0.98634437
98MP0001764_abnormal_homeostasis0.97909651
99MP0002098_abnormal_vibrissa_morphology0.96234764
100MP0000358_abnormal_cell_content/0.94049625
101MP0008961_abnormal_basal_metabolism0.93848787
102MP0002398_abnormal_bone_marrow0.91759124
103MP0009785_altered_susceptibility_to0.91639090
104MP0001790_abnormal_immune_system0.90709046
105MP0005387_immune_system_phenotype0.90709046
106MP0003453_abnormal_keratinocyte_physiol0.89921906
107MP0000477_abnormal_intestine_morphology0.89616480
108MP0005408_hypopigmentation0.89152068
109MP0002429_abnormal_blood_cell0.87998000
110MP0002419_abnormal_innate_immunity0.87367275
111MP0000604_amyloidosis0.86000530
112MP0000538_abnormal_urinary_bladder0.85187604
113MP0000598_abnormal_liver_morphology0.83916517
114MP0001800_abnormal_humoral_immune0.83410685
115MP0001835_abnormal_antigen_presentation0.83314790
116MP0010307_abnormal_tumor_latency0.83008384
117MP0001853_heart_inflammation0.82121382
118MP0000703_abnormal_thymus_morphology0.81934851
119MP0005000_abnormal_immune_tolerance0.81716452
120MP0001873_stomach_inflammation0.80992061
121MP0003172_abnormal_lysosome_physiology0.80895938
122MP0004197_abnormal_fetal_growth/weight/0.80656007
123MP0009763_increased_sensitivity_to0.80255797
124MP0008995_early_reproductive_senescence0.80199938
125MP0003806_abnormal_nucleotide_metabolis0.79443818
126MP0005584_abnormal_enzyme/coenzyme_acti0.79334151
127MP0005023_abnormal_wound_healing0.79021370
128MP0005464_abnormal_platelet_physiology0.78704717
129MP0003303_peritoneal_inflammation0.78244288
130MP0005409_darkened_coat_color0.77815807
131MP0002653_abnormal_ependyma_morphology0.77094083
132MP0003221_abnormal_cardiomyocyte_apopto0.76739486
133MP0001293_anophthalmia0.76735868
134MP0000537_abnormal_urethra_morphology0.76419756
135MP0000858_altered_metastatic_potential0.76082072
136MP0004272_abnormal_basement_membrane0.75823703
137MP0005501_abnormal_skin_physiology0.73112829
138MP0009642_abnormal_blood_homeostasis0.73057535
139MP0001845_abnormal_inflammatory_respons0.72779641
140MP0003195_calcinosis0.72266111
141MP0002970_abnormal_white_adipose0.71878601
142MP0002723_abnormal_immune_serum0.71579580
143MP0004858_abnormal_nervous_system0.71330666
144MP0005671_abnormal_response_to0.70205020
145MP0001881_abnormal_mammary_gland0.69866951
146MP0004233_abnormal_muscle_weight0.69351595
147MP0006082_CNS_inflammation0.68695249
148MP0001216_abnormal_epidermal_layer0.68382748
149MP0002111_abnormal_tail_morphology0.68346875
150MP0009053_abnormal_anal_canal0.67840888
151MP0002166_altered_tumor_susceptibility0.67528267
152MP0010155_abnormal_intestine_physiology0.67431642
153MP0009672_abnormal_birth_weight0.67272056
154MP0003183_abnormal_peptide_metabolism0.66614668
155MP0008875_abnormal_xenobiotic_pharmacok0.65877757
156MP0001849_ear_inflammation0.65282010
157MP0010234_abnormal_vibrissa_follicle0.64879744
158MP0002420_abnormal_adaptive_immunity0.64162900
159MP0002452_abnormal_antigen_presenting0.63294926
160MP0001819_abnormal_immune_cell0.63269991
161MP0003075_altered_response_to0.63092783
162MP0000003_abnormal_adipose_tissue0.62539254
163MP0000716_abnormal_immune_system0.62434137

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)8.59257835
2Abnormality of monocarboxylic acid metabolism (HP:0010996)6.05991603
3Prolonged partial thromboplastin time (HP:0003645)5.85148303
4Joint hemorrhage (HP:0005261)5.23149942
5Abnormality of aromatic amino acid family metabolism (HP:0004338)5.08500191
6Increased circulating renin level (HP:0000848)4.86319775
7Hypobetalipoproteinemia (HP:0003563)4.80802514
8Polyuria (HP:0000103)4.80773899
9Gout (HP:0001997)4.68366496
10Reticulocytopenia (HP:0001896)4.64100426
11Complement deficiency (HP:0004431)4.60362154
12Hemorrhage of the eye (HP:0011885)4.49452892
13Systemic lupus erythematosus (HP:0002725)4.41506990
14Abnormal urine output (HP:0012590)4.35237846
15Hypomagnesemia (HP:0002917)4.31378715
16Hypokalemic alkalosis (HP:0001949)4.25793023
17Hyperactive renin-angiotensin system (HP:0000841)4.19426029
18Abnormality of complement system (HP:0005339)4.14923957
19Abnormality of renal excretion (HP:0011036)4.11362937
20Abnormality of magnesium homeostasis (HP:0004921)4.04864601
21Abnormality of the common coagulation pathway (HP:0010990)3.94607120
22Abnormal drinking behavior (HP:0030082)3.92055563
23Polydipsia (HP:0001959)3.92055563
24Xanthomatosis (HP:0000991)3.91714391
25Conjugated hyperbilirubinemia (HP:0002908)3.82903851
26Metabolic alkalosis (HP:0200114)3.74809782
27Tetany (HP:0001281)3.69390640
28Proximal tubulopathy (HP:0000114)3.52728574
29Abnormality of chloride homeostasis (HP:0011422)3.42143331
30Hypercalciuria (HP:0002150)3.37575797
31IgM deficiency (HP:0002850)3.28362472
32Hypercholesterolemia (HP:0003124)3.23694481
33Thrombocytosis (HP:0001894)3.23151275
34Increased purine levels (HP:0004368)3.19900178
35Hyperuricemia (HP:0002149)3.19900178
36Purpura (HP:0000979)3.18873527
37Glomerulonephritis (HP:0000099)3.03122392
38Renal salt wasting (HP:0000127)3.02500746
39Cholecystitis (HP:0001082)2.97996310
40Abnormal gallbladder physiology (HP:0012438)2.97996310
41Vacuolated lymphocytes (HP:0001922)2.97567678
42Generalized aminoaciduria (HP:0002909)2.95763824
43Intrahepatic cholestasis (HP:0001406)2.87929926
44Vascular calcification (HP:0004934)2.85643984
45Recurrent gram-negative bacterial infections (HP:0005420)2.80553948
46Hypolipoproteinemia (HP:0010981)2.76777943
47Abnormality of renin-angiotensin system (HP:0000847)2.75870885
48Menorrhagia (HP:0000132)2.71893076
49Abnormality of the Achilles tendon (HP:0005109)2.71706593
50Petechiae (HP:0000967)2.70747741
51Hyperaldosteronism (HP:0000859)2.70148763
52Abnormality of cells of the erythroid lineage (HP:0012130)2.68736350
53Hyperlipoproteinemia (HP:0010980)2.65985909
54Microretrognathia (HP:0000308)2.65914612
55Macrocytic anemia (HP:0001972)2.64300658
56Hyperglycinuria (HP:0003108)2.64107294
57Abnormality of purine metabolism (HP:0004352)2.61076332
58Abnormal number of erythroid precursors (HP:0012131)2.54380910
59Abnormality of the intrinsic pathway (HP:0010989)2.52966137
60Oral leukoplakia (HP:0002745)2.47885239
61Rickets (HP:0002748)2.46944669
62Myocardial infarction (HP:0001658)2.46461596
63Alkalosis (HP:0001948)2.43247245
64Cardiovascular calcification (HP:0011915)2.43145046
65Rough bone trabeculation (HP:0100670)2.42478956
66Gingival bleeding (HP:0000225)2.41127731
67Delayed CNS myelination (HP:0002188)2.40908577
68Abnormality of nucleobase metabolism (HP:0010932)2.39242866
69Multiple enchondromatosis (HP:0005701)2.38768044
70Spontaneous abortion (HP:0005268)2.38407438
71Mitral stenosis (HP:0001718)2.34763543
72Colon cancer (HP:0003003)2.33804188
73Abnormal platelet function (HP:0011869)2.32615810
74Impaired platelet aggregation (HP:0003540)2.32615810
75Abnormality of glutamine family amino acid metabolism (HP:0010902)2.31788339
76Glycosuria (HP:0003076)2.31009944
77Abnormality of urine glucose concentration (HP:0011016)2.31009944
78Thrombophlebitis (HP:0004418)2.30780527
79Hyperphosphaturia (HP:0003109)2.27888039
80Nephritis (HP:0000123)2.26842537
81Aplastic anemia (HP:0001915)2.25440218
82Metaphyseal cupping (HP:0003021)2.24934541
83Nephrocalcinosis (HP:0000121)2.23462713
84Reticulocytosis (HP:0001923)2.22657745
85Prolonged neonatal jaundice (HP:0006579)2.22254987
86Hepatocellular carcinoma (HP:0001402)2.18592091
87Basal cell carcinoma (HP:0002671)2.18421490
88Achilles tendon contracture (HP:0001771)2.16068907
89Carpal bone hypoplasia (HP:0001498)2.14949036
90Back pain (HP:0003418)2.14081088
91Abnormality of polysaccharide metabolism (HP:0011012)2.13352884
92Abnormality of glycosaminoglycan metabolism (HP:0004371)2.13352884
93Abnormality of mucopolysaccharide metabolism (HP:0011020)2.13352884
94Flat acetabular roof (HP:0003180)2.12798717
95Mucopolysacchariduria (HP:0008155)2.12296101
96Urinary glycosaminoglycan excretion (HP:0003541)2.12296101
97Megaloblastic anemia (HP:0001889)2.11143095
98Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.11038678
99Asymmetry of the thorax (HP:0001555)2.09657797
100Hyperammonemia (HP:0001987)2.09621584
101Abnormal urine phosphate concentration (HP:0012599)2.09109245
102Fat malabsorption (HP:0002630)2.08684381
103Elevated erythrocyte sedimentation rate (HP:0003565)2.08520037
104Increased serum ferritin (HP:0003281)2.07793608
105Nonimmune hydrops fetalis (HP:0001790)2.07480426
106Polygenic inheritance (HP:0010982)2.04583411
107Rhabdomyosarcoma (HP:0002859)2.03953072
108Bilateral sensorineural hearing impairment (HP:0008619)2.03685411
109Bicornuate uterus (HP:0000813)2.02137145
110Hypophosphatemic rickets (HP:0004912)2.00130517
111Pulmonary embolism (HP:0002204)1.99889787
112Nephrolithiasis (HP:0000787)1.99547658
113Abnormality of serine family amino acid metabolism (HP:0010894)1.99391701
114Abnormality of glycine metabolism (HP:0010895)1.99391701
115Renal tubular acidosis (HP:0001947)1.98259945
116Epistaxis (HP:0000421)1.95999861
117Abnormality of pyrimidine metabolism (HP:0004353)1.95575935
118Hypokalemia (HP:0002900)1.93327808
119Gangrene (HP:0100758)1.93168678
120Pallor (HP:0000980)1.91690610
121Abnormal trabecular bone morphology (HP:0100671)1.91343569
122Delayed epiphyseal ossification (HP:0002663)1.90396329
123Abnormality of macrophages (HP:0004311)1.86958460
124Ketoacidosis (HP:0001993)1.86541298
125Seborrheic dermatitis (HP:0001051)1.85871252
126Hyperbilirubinemia (HP:0002904)1.85481487
127Hyponatremia (HP:0002902)1.84371847
128Vertebral compression fractures (HP:0002953)1.83083930
129Hypertriglyceridemia (HP:0002155)1.82788869
130High anterior hairline (HP:0009890)1.82711620
131Amaurosis fugax (HP:0100576)1.82474727
132Elevated alkaline phosphatase (HP:0003155)1.82468359
133Abnormality of alkaline phosphatase activity (HP:0004379)1.80569054
134Angiofibromas (HP:0010615)1.80433255
135Adenoma sebaceum (HP:0009720)1.80433255
136Abnormal platelet volume (HP:0011876)1.80302712
137Chondrocalcinosis (HP:0000934)1.79335694
138Abnormal enzyme/coenzyme activity (HP:0012379)1.79156100
139Cholelithiasis (HP:0001081)1.79153499
140Obstructive lung disease (HP:0006536)1.78864481
141Chronic obstructive pulmonary disease (HP:0006510)1.78864481
142Abnormality of glycolysis (HP:0004366)1.78852654
143Degeneration of anterior horn cells (HP:0002398)1.78224800
144Abnormality of the anterior horn cell (HP:0006802)1.78224800
145Esophageal varix (HP:0002040)1.77248568
146Abnormality of carpal bone ossification (HP:0006257)1.76684082
147Lymphangioma (HP:0100764)1.76508241
148Premature ovarian failure (HP:0008209)1.76350278
149Cervical subluxation (HP:0003308)1.75879114
150Thin bony cortex (HP:0002753)1.75127728
151Abnormality of fatty-acid metabolism (HP:0004359)1.74828661
152Selective tooth agenesis (HP:0001592)1.73615419
153Nausea (HP:0002018)1.73607795
154Squamous cell carcinoma (HP:0002860)1.73586466
155Dicarboxylic aciduria (HP:0003215)1.73565852
156Abnormality of dicarboxylic acid metabolism (HP:0010995)1.73565852
157Reduced antithrombin III activity (HP:0001976)1.72785084
158Increased serum pyruvate (HP:0003542)1.72682671
159Agnosia (HP:0010524)1.72491624
160Abnormality of reticulocytes (HP:0004312)1.72316234
161Abnormal number of incisors (HP:0011064)1.72131766
162Severe short stature (HP:0003510)1.71670286
163Neoplasm of striated muscle (HP:0009728)1.70915752
164Malnutrition (HP:0004395)1.69509517
165Aplasia/Hypoplasia of the sacrum (HP:0008517)1.68493330
166Bifid scrotum (HP:0000048)1.68395005
167Abnormality of the lumbar spine (HP:0100712)1.67427519
168Dysostosis multiplex (HP:0000943)1.66896681
169Lower limb hyperreflexia (HP:0002395)1.65174516
170Abnormality of sodium homeostasis (HP:0010931)1.65138475
171Increased mean platelet volume (HP:0011877)1.65026009
172Pancytopenia (HP:0001876)1.64170090
173Meningitis (HP:0001287)1.63948602
174Polycythemia (HP:0001901)1.63313509
175Abnormality of iron homeostasis (HP:0011031)1.63197273
176Poikiloderma (HP:0001029)1.63064473
177Hypoalphalipoproteinemia (HP:0003233)1.62835632
17811 pairs of ribs (HP:0000878)1.62519856
179Ependymoma (HP:0002888)1.62316052
180Abnormal tarsal ossification (HP:0008369)1.61929052
181J-shaped sella turcica (HP:0002680)1.61730741
182Steatorrhea (HP:0002570)1.60594748
183Abnormality of the thoracic spine (HP:0100711)1.60456331
184Abnormality of the nasal mucosa (HP:0000433)1.59257003
185Arterial thrombosis (HP:0004420)1.59067490
186Type I transferrin isoform profile (HP:0003642)1.58931654
187Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.57184803
188Hypochromic anemia (HP:0001931)1.56377408
189Gastrointestinal infarctions (HP:0005244)1.56207051
190Abnormal gallbladder morphology (HP:0012437)1.56190935
191Hypophosphatemia (HP:0002148)1.56131009
192Ureteral stenosis (HP:0000071)1.55380119
193Thoracic kyphosis (HP:0002942)1.54741656

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.20039514
2SMG13.91963805
3ACVR1B3.45932836
4FGFR43.36120476
5WEE12.92952591
6BUB12.78993025
7TGFBR12.76774885
8ICK2.61306175
9SIK12.56517314
10WNK42.55936032
11IRAK32.53072462
12PRPF4B2.52076113
13EPHA22.45156447
14WNK32.26844003
15EEF2K2.25566655
16KDR2.18486765
17MAP4K12.11671561
18NME22.11481557
19PASK2.01750852
20NEK11.93673179
21EIF2AK11.93059347
22PAK41.84906640
23OXSR11.83829133
24DYRK31.81115852
25CDC71.69699982
26SRPK11.69203313
27TESK11.67572562
28MST1R1.66157628
29STK101.65987651
30LRRK21.65831530
31PIM21.63441901
32RIPK11.62686131
33TSSK61.62406833
34KIT1.58949075
35ERN11.58821659
36FLT31.54984996
37TTK1.54949534
38SCYL21.54670146
39TESK21.45959529
40BCKDK1.45759900
41TGFBR21.43513173
42NEK21.41819363
43MAP3K31.37322924
44MKNK11.32091861
45MAP3K141.30795541
46CDK71.30091016
47STK161.23495293
48TAOK21.22102685
49BTK1.20631831
50RPS6KB21.20601688
51MAPKAPK31.15667922
52IRAK41.14642164
53CDK41.14049078
54TEC1.14005891
55VRK21.13936360
56PKN21.11888055
57MAP3K81.11095272
58BRSK21.10404246
59MAP3K111.08307524
60MAP3K131.07970612
61RPS6KA41.06830954
62VRK11.04729595
63TYK21.04607562
64PLK41.04103958
65PDGFRA1.04065246
66BLK1.03959618
67CSF1R1.02655000
68PLK11.02006477
69RIPK41.01733604
70TAOK11.00784571
71ATR1.00367981
72PIM10.97285034
73AURKB0.96112989
74MAP3K60.95628245
75MAP2K30.94411446
76ZAP700.92636496
77JAK30.91907613
78PDPK10.90600712
79EPHB10.90326173
80FGFR30.86493017
81CSK0.85607946
82AURKA0.84485783
83MKNK20.82955512
84MAP3K10.81144595
85MAP3K100.80022643
86TXK0.76053389
87AKT20.75596876
88CDK120.75240625
89MAP2K20.74086538
90CDK90.73583701
91TNK20.71567056
92KSR20.70981371
93NEK90.70606077
94STK40.69718310
95MATK0.68960903
96TLK10.68193793
97PRKD20.66794167
98CHEK20.64256639
99MET0.62592899
100MAP2K60.60952184
101CDC42BPA0.60610198
102PDK10.60488816
103TBK10.60021275
104TRIB30.57632993
105GRK60.54513086
106BRSK10.53179553
107CDK80.53165208
108EIF2AK30.52718097
109PAK10.50598644
110PTK60.50235422
111BRD40.49391493
112DYRK1B0.49347477
113CHEK10.48379160
114RET0.48079946
115MAPKAPK20.47614873
116IRAK20.46922509
117LATS10.46258035
118PTK20.43857708
119CHUK0.43541902
120IKBKE0.43359076
121GRK10.43323297
122MELK0.42492278
123CDK60.41916815
124IKBKB0.41644720
125LATS20.41205267
126SIK30.38527549
127PRKCI0.37855089
128MOS0.37355583
129LCK0.37303460
130CDK20.35949611
131ARAF0.35308548
132STK38L0.35134336
133FGR0.34945335
134BRAF0.34923856
135PRKG20.34734977
136MTOR0.34483439
137ITK0.34379258
138CCNB10.33868694
139CDK190.31625457
140CAMK1D0.31152287
141PRKAA20.31052058
142ABL20.30639410
143BMX0.30329042
144SYK0.29069009
145LMTK20.28095695
146CSNK2A20.28069367
147MARK20.27405769
148ILK0.26487519
149MAPK110.26475824
150TTN0.26296973
151DAPK10.25929481
152CSNK2A10.25912567

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.19202583
2DNA replication_Homo sapiens_hsa030304.16320102
3Complement and coagulation cascades_Homo sapiens_hsa046103.76497309
4Ribosome_Homo sapiens_hsa030103.17109529
5Mismatch repair_Homo sapiens_hsa034302.98679331
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.85386578
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.71477201
8Base excision repair_Homo sapiens_hsa034102.69605359
9Phenylalanine metabolism_Homo sapiens_hsa003602.49884743
10Proteasome_Homo sapiens_hsa030502.47889979
11Spliceosome_Homo sapiens_hsa030402.47401702
12Caffeine metabolism_Homo sapiens_hsa002322.46361028
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.16516853
14Retinol metabolism_Homo sapiens_hsa008302.15749424
15RNA polymerase_Homo sapiens_hsa030202.08241887
16Homologous recombination_Homo sapiens_hsa034402.06796701
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.03474843
18RNA transport_Homo sapiens_hsa030131.96720915
19Arginine biosynthesis_Homo sapiens_hsa002201.96572351
20Cell cycle_Homo sapiens_hsa041101.96035214
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.95990883
22Other glycan degradation_Homo sapiens_hsa005111.95639838
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.95299045
24Pyrimidine metabolism_Homo sapiens_hsa002401.93660463
25One carbon pool by folate_Homo sapiens_hsa006701.91800884
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.91687094
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88375749
28Nucleotide excision repair_Homo sapiens_hsa034201.84213468
29Chemical carcinogenesis_Homo sapiens_hsa052041.79731917
30Selenocompound metabolism_Homo sapiens_hsa004501.76367751
31Tyrosine metabolism_Homo sapiens_hsa003501.61234268
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.61041495
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.59004270
34Pentose phosphate pathway_Homo sapiens_hsa000301.51758116
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.46761153
36Vitamin digestion and absorption_Homo sapiens_hsa049771.42325334
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41860577
38Staphylococcus aureus infection_Homo sapiens_hsa051501.40072100
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39417599
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.37590302
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.35899542
42Folate biosynthesis_Homo sapiens_hsa007901.33710576
43PPAR signaling pathway_Homo sapiens_hsa033201.32438478
44Butanoate metabolism_Homo sapiens_hsa006501.31431649
45Glutathione metabolism_Homo sapiens_hsa004801.29969151
46Starch and sucrose metabolism_Homo sapiens_hsa005001.29772926
47Biosynthesis of amino acids_Homo sapiens_hsa012301.28350802
48Steroid biosynthesis_Homo sapiens_hsa001001.27710528
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25469704
50Carbon metabolism_Homo sapiens_hsa012001.21692120
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.21318844
52Prion diseases_Homo sapiens_hsa050201.21216859
53Histidine metabolism_Homo sapiens_hsa003401.18436568
54p53 signaling pathway_Homo sapiens_hsa041151.16116128
55Vitamin B6 metabolism_Homo sapiens_hsa007501.14513418
56RNA degradation_Homo sapiens_hsa030181.09612214
57Sulfur relay system_Homo sapiens_hsa041221.04730571
58Lysine degradation_Homo sapiens_hsa003101.04391545
59N-Glycan biosynthesis_Homo sapiens_hsa005101.03919704
60Fanconi anemia pathway_Homo sapiens_hsa034601.03326731
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02137643
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02033934
63Cysteine and methionine metabolism_Homo sapiens_hsa002701.00916877
64Peroxisome_Homo sapiens_hsa041460.99592055
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99403434
66Non-homologous end-joining_Homo sapiens_hsa034500.99231338
67beta-Alanine metabolism_Homo sapiens_hsa004100.94308258
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91080739
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.90793015
70Fat digestion and absorption_Homo sapiens_hsa049750.90304128
71Galactose metabolism_Homo sapiens_hsa000520.89127961
72Fatty acid degradation_Homo sapiens_hsa000710.88860643
73Propanoate metabolism_Homo sapiens_hsa006400.88770192
74Antigen processing and presentation_Homo sapiens_hsa046120.88444574
75Notch signaling pathway_Homo sapiens_hsa043300.87314734
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86207797
77Thyroid cancer_Homo sapiens_hsa052160.84238154
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82028085
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81842046
80Renin-angiotensin system_Homo sapiens_hsa046140.81143932
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79236833
82Pyruvate metabolism_Homo sapiens_hsa006200.78937688
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78396582
84Arginine and proline metabolism_Homo sapiens_hsa003300.78007220
85Purine metabolism_Homo sapiens_hsa002300.77539064
86Fructose and mannose metabolism_Homo sapiens_hsa000510.76468989
87Bladder cancer_Homo sapiens_hsa052190.73856528
88Shigellosis_Homo sapiens_hsa051310.72337960
89Small cell lung cancer_Homo sapiens_hsa052220.71266375
90ABC transporters_Homo sapiens_hsa020100.69901756
91mRNA surveillance pathway_Homo sapiens_hsa030150.66734042
92Epstein-Barr virus infection_Homo sapiens_hsa051690.64134642
93Legionellosis_Homo sapiens_hsa051340.62754302
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.61732811
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.60775751
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.58223955
97Fatty acid biosynthesis_Homo sapiens_hsa000610.56731045
98Lysosome_Homo sapiens_hsa041420.55079995
99Tryptophan metabolism_Homo sapiens_hsa003800.54574924
100Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54302010
101Primary immunodeficiency_Homo sapiens_hsa053400.54157673
102Fatty acid elongation_Homo sapiens_hsa000620.53506970
103Pertussis_Homo sapiens_hsa051330.53376055
104Herpes simplex infection_Homo sapiens_hsa051680.50859411
105HTLV-I infection_Homo sapiens_hsa051660.48374940
106Insulin resistance_Homo sapiens_hsa049310.46900848
107Basal transcription factors_Homo sapiens_hsa030220.46370861
108Non-small cell lung cancer_Homo sapiens_hsa052230.45631109
109MicroRNAs in cancer_Homo sapiens_hsa052060.45253622
110B cell receptor signaling pathway_Homo sapiens_hsa046620.45190045
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44468043
112Hepatitis C_Homo sapiens_hsa051600.43587106
113NF-kappa B signaling pathway_Homo sapiens_hsa040640.42851299
114Chronic myeloid leukemia_Homo sapiens_hsa052200.42528428
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41451801
116Viral carcinogenesis_Homo sapiens_hsa052030.41195331
117Fatty acid metabolism_Homo sapiens_hsa012120.39340726
118Acute myeloid leukemia_Homo sapiens_hsa052210.39254664
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38774208
120Metabolic pathways_Homo sapiens_hsa011000.38747890
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37895952
122Apoptosis_Homo sapiens_hsa042100.37500077
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37420322
124Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36992736
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35519668
126Protein export_Homo sapiens_hsa030600.31749336
127Protein digestion and absorption_Homo sapiens_hsa049740.31440371
128Bile secretion_Homo sapiens_hsa049760.30946811
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.30945626
130Systemic lupus erythematosus_Homo sapiens_hsa053220.30226299
131Hepatitis B_Homo sapiens_hsa051610.30221437
132RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27938248
133Basal cell carcinoma_Homo sapiens_hsa052170.26330349
134Mineral absorption_Homo sapiens_hsa049780.25528410
135Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25457178
136Measles_Homo sapiens_hsa051620.25204718
137Hippo signaling pathway_Homo sapiens_hsa043900.25188512
138Pancreatic cancer_Homo sapiens_hsa052120.24933698
139Leishmaniasis_Homo sapiens_hsa051400.24819515
140T cell receptor signaling pathway_Homo sapiens_hsa046600.24585233
141Insulin signaling pathway_Homo sapiens_hsa049100.24337160
142Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23184250
143Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23146371
144Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23007213
145Colorectal cancer_Homo sapiens_hsa052100.22258078
146Arachidonic acid metabolism_Homo sapiens_hsa005900.21818196
147VEGF signaling pathway_Homo sapiens_hsa043700.21280827
148Salmonella infection_Homo sapiens_hsa051320.18893341

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