SLC16A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an integral membrane protein that functions as a transporter of thyroid hormone. The encoded protein facilitates the cellular importation of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). This gene is expressed in many tissues and likely plays an important role in the development of the central nervous system. Loss of function mutations in this gene are associated with psychomotor retardation in males while females exhibit no neurological defects and more moderate thyroid-deficient phenotypes. This gene is subject to X-chromosome inactivation. Mutations in this gene are the cause of Allan-Herndon-Dudley syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.78615378
2L-phenylalanine catabolic process (GO:0006559)6.78615378
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.47041823
4L-phenylalanine metabolic process (GO:0006558)6.47041823
5aromatic amino acid family catabolic process (GO:0009074)6.11588867
6glyoxylate metabolic process (GO:0046487)5.66446420
7tryptophan catabolic process (GO:0006569)5.57788934
8indole-containing compound catabolic process (GO:0042436)5.57788934
9indolalkylamine catabolic process (GO:0046218)5.57788934
10kynurenine metabolic process (GO:0070189)5.44415668
11alpha-linolenic acid metabolic process (GO:0036109)5.43717907
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.33111942
13bile acid biosynthetic process (GO:0006699)5.32474717
14tryptophan metabolic process (GO:0006568)5.26410119
15cysteine metabolic process (GO:0006534)5.09262401
16lysine metabolic process (GO:0006553)4.96295544
17lysine catabolic process (GO:0006554)4.96295544
18sulfur amino acid catabolic process (GO:0000098)4.82850802
19urea metabolic process (GO:0019627)4.80983198
20urea cycle (GO:0000050)4.80983198
21cellular ketone body metabolic process (GO:0046950)4.79134974
22negative regulation of fibrinolysis (GO:0051918)4.76943076
23high-density lipoprotein particle remodeling (GO:0034375)4.76003339
24serine family amino acid catabolic process (GO:0009071)4.75013876
25protein carboxylation (GO:0018214)4.70008611
26peptidyl-glutamic acid carboxylation (GO:0017187)4.70008611
27fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.65780579
28regulation of fibrinolysis (GO:0051917)4.63222581
29regulation of protein activation cascade (GO:2000257)4.50290885
30homocysteine metabolic process (GO:0050667)4.50088328
31complement activation, alternative pathway (GO:0006957)4.48722303
32amino-acid betaine metabolic process (GO:0006577)4.44131712
33bile acid metabolic process (GO:0008206)4.43740333
34nitrogen cycle metabolic process (GO:0071941)4.40496246
35aromatic amino acid family metabolic process (GO:0009072)4.39392220
36alpha-amino acid catabolic process (GO:1901606)4.28540538
37reverse cholesterol transport (GO:0043691)4.28319819
38cellular modified amino acid catabolic process (GO:0042219)4.23013556
39regulation of complement activation (GO:0030449)4.22155407
40tyrosine metabolic process (GO:0006570)4.21141753
41glutamate metabolic process (GO:0006536)4.17689869
42ketone body metabolic process (GO:1902224)4.12729384
43dicarboxylic acid biosynthetic process (GO:0043650)4.07980698
44protein-lipid complex remodeling (GO:0034368)4.03529141
45macromolecular complex remodeling (GO:0034367)4.03529141
46plasma lipoprotein particle remodeling (GO:0034369)4.03529141
47postsynaptic membrane organization (GO:0001941)4.03513620
48regulation of cholesterol esterification (GO:0010872)4.03051019
49negative regulation of cholesterol transport (GO:0032375)4.02940212
50negative regulation of sterol transport (GO:0032372)4.02940212
51cellular amino acid catabolic process (GO:0009063)4.02376137
52drug catabolic process (GO:0042737)4.02034733
53urate metabolic process (GO:0046415)4.00327548
54regulation of triglyceride catabolic process (GO:0010896)3.94110056
55drug transmembrane transport (GO:0006855)3.93921024
56coenzyme catabolic process (GO:0009109)3.91048332
57pyrimidine nucleobase catabolic process (GO:0006208)3.89757174
58indolalkylamine metabolic process (GO:0006586)3.89148547
59acylglycerol homeostasis (GO:0055090)3.87204879
60triglyceride homeostasis (GO:0070328)3.87204879
61benzene-containing compound metabolic process (GO:0042537)3.86868090
62presynaptic membrane assembly (GO:0097105)3.84949898
63cellular glucuronidation (GO:0052695)3.83906331
64short-chain fatty acid metabolic process (GO:0046459)3.79751086
65serine family amino acid metabolic process (GO:0009069)3.79162360
66cellular biogenic amine catabolic process (GO:0042402)3.77071241
67amine catabolic process (GO:0009310)3.77071241
68ethanol oxidation (GO:0006069)3.74418069
69phospholipid efflux (GO:0033700)3.67915533
70aspartate family amino acid catabolic process (GO:0009068)3.64937853
71axonal fasciculation (GO:0007413)3.62508610
72exogenous drug catabolic process (GO:0042738)3.61030605
73bile acid and bile salt transport (GO:0015721)3.60977655
74glycine metabolic process (GO:0006544)3.58842602
75plasma lipoprotein particle clearance (GO:0034381)3.58399877
76arginine metabolic process (GO:0006525)3.58145951
77acetyl-CoA metabolic process (GO:0006084)3.57480516
78regulation of cholesterol homeostasis (GO:2000188)3.56825686
79organic acid catabolic process (GO:0016054)3.50652539
80carboxylic acid catabolic process (GO:0046395)3.50652539
81cholesterol efflux (GO:0033344)3.50619049
82serine family amino acid biosynthetic process (GO:0009070)3.50067993
83glucuronate metabolic process (GO:0019585)3.45977241
84uronic acid metabolic process (GO:0006063)3.45977241
85neuron projection extension involved in neuron projection guidance (GO:1902284)3.44248773
86axon extension involved in axon guidance (GO:0048846)3.44248773
87presynaptic membrane organization (GO:0097090)3.44009214
88imidazole-containing compound metabolic process (GO:0052803)3.42700015
89fibrinolysis (GO:0042730)3.40157093
90regulation of bile acid biosynthetic process (GO:0070857)3.39801481
91low-density lipoprotein particle remodeling (GO:0034374)3.38673414
92positive regulation of fatty acid beta-oxidation (GO:0032000)3.33559405
932-oxoglutarate metabolic process (GO:0006103)3.32867161
94neuron recognition (GO:0008038)3.32632943
95phospholipid homeostasis (GO:0055091)3.32514067
96nucleobase catabolic process (GO:0046113)3.32428965
97aldehyde catabolic process (GO:0046185)3.31215902
98positive regulation of lipid catabolic process (GO:0050996)3.30542798
99negative regulation of axon guidance (GO:1902668)3.29107007
100monocarboxylic acid catabolic process (GO:0072329)3.28881553
101carnitine metabolic process (GO:0009437)3.27655153
102regulation of plasminogen activation (GO:0010755)3.27452310
103fatty acid beta-oxidation (GO:0006635)3.27237262
104flavonoid metabolic process (GO:0009812)3.25390320
105fatty acid oxidation (GO:0019395)3.24671338
106plasma lipoprotein particle assembly (GO:0034377)3.23148839
107drug transport (GO:0015893)3.21757799
108lipid oxidation (GO:0034440)3.20407168
109negative regulation of axon extension involved in axon guidance (GO:0048843)3.09230738
110axon extension (GO:0048675)3.05859531
111dendritic spine morphogenesis (GO:0060997)3.00393446
112protein heterotrimerization (GO:0070208)2.95696413
113lateral sprouting from an epithelium (GO:0060601)2.94627872
114regulation of axon guidance (GO:1902667)2.93585587
115retinal ganglion cell axon guidance (GO:0031290)2.92094081
116limb bud formation (GO:0060174)2.91582716
117positive regulation of synapse assembly (GO:0051965)2.89550138
118spinal cord development (GO:0021510)2.79290643
119regulation of axon extension involved in axon guidance (GO:0048841)2.76923636
120G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.74234567
121regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.73388162
122establishment of tissue polarity (GO:0007164)2.72563347
123establishment of planar polarity (GO:0001736)2.72563347
124paraxial mesoderm development (GO:0048339)2.70407404
125central nervous system projection neuron axonogenesis (GO:0021952)2.70147823
126neuron cell-cell adhesion (GO:0007158)2.68281038
127hemidesmosome assembly (GO:0031581)2.66229923
128calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.64134013
129bone trabecula formation (GO:0060346)2.60701987
130behavioral response to nicotine (GO:0035095)2.59060898
131negative chemotaxis (GO:0050919)2.51351851
132omega-hydroxylase P450 pathway (GO:0097267)2.49906988
133kidney mesenchyme development (GO:0072074)2.48988740
134cerebral cortex radially oriented cell migration (GO:0021799)2.48644262
135vocalization behavior (GO:0071625)2.47310011
136cell migration involved in sprouting angiogenesis (GO:0002042)2.46002755
137neuron projection extension (GO:1990138)2.44861715
138regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.44547279
139regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.41209241
140collagen fibril organization (GO:0030199)2.40843887
141planar cell polarity pathway involved in neural tube closure (GO:0090179)2.40329271
142positive regulation of gastrulation (GO:2000543)2.37806065
143ganglion development (GO:0061548)2.35899692
144synapse assembly (GO:0007416)2.35556258
145metanephric mesenchyme development (GO:0072075)2.33202380
146regulation of synapse assembly (GO:0051963)2.30096696
147olfactory bulb development (GO:0021772)2.29607311
148regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.27764703
149chondrocyte proliferation (GO:0035988)2.27225623
150oxidative demethylation (GO:0070989)2.24525543
151camera-type eye morphogenesis (GO:0048593)2.23811274
152cochlea morphogenesis (GO:0090103)2.23623387
153Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.23299873
154protein localization to synapse (GO:0035418)2.21365980
155regulation of respiratory system process (GO:0044065)2.21141094
156gamma-aminobutyric acid transport (GO:0015812)2.20003298
157limb development (GO:0060173)2.18878441
158appendage development (GO:0048736)2.18878441
159endodermal cell differentiation (GO:0035987)2.18330636
160neuron fate determination (GO:0048664)2.17316936
161head development (GO:0060322)2.17243380
162regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.17053736
163dermatan sulfate biosynthetic process (GO:0030208)2.16701004
164regulation of establishment of planar polarity (GO:0090175)2.16392284
165epoxygenase P450 pathway (GO:0019373)2.16262054
166convergent extension (GO:0060026)2.16154361
167central nervous system neuron axonogenesis (GO:0021955)2.15176725
168cranial nerve morphogenesis (GO:0021602)2.13623921
169regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.13607274
170negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.13531097
171outer ear morphogenesis (GO:0042473)2.12986674
172inner ear receptor cell development (GO:0060119)2.12062982
173somite development (GO:0061053)2.12038435
174sequestering of actin monomers (GO:0042989)2.11997128
175transmission of nerve impulse (GO:0019226)2.10628358
176cell proliferation in forebrain (GO:0021846)2.10093471
177lens fiber cell development (GO:0070307)2.06177298
178negative regulation of axon extension (GO:0030517)2.05621634
179substrate-independent telencephalic tangential migration (GO:0021826)2.05579558
180substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.05579558
181neural crest cell development (GO:0014032)2.04159719
182negative regulation of synaptic transmission, GABAergic (GO:0032229)2.02986679
183non-canonical Wnt signaling pathway (GO:0035567)2.02147616
184lymphangiogenesis (GO:0001946)2.02004314
185apical protein localization (GO:0045176)2.01998399
186kidney morphogenesis (GO:0060993)2.01606193
187regulation of non-canonical Wnt signaling pathway (GO:2000050)2.00573506
188short-term memory (GO:0007614)1.99679173
189sequestering of extracellular ligand from receptor (GO:0035581)1.99399436

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.11051077
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.55196637
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.49110597
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.15163541
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.64337007
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.15328030
7EZH2_22144423_ChIP-Seq_EOC_Human4.06894926
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.97531273
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.47093012
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.00929983
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.54836575
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.27643605
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.23404401
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.20980997
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07548358
16SALL1_21062744_ChIP-ChIP_HESCs_Human1.89426752
17WT1_19549856_ChIP-ChIP_CCG9911_Human1.84455298
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81911689
19TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.79380067
20* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77802944
21CLOCK_20551151_ChIP-Seq_293T_Human1.68990035
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65275022
23FOXA2_19822575_ChIP-Seq_HepG2_Human1.59595578
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56178675
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48478849
26* SMAD4_21799915_ChIP-Seq_A2780_Human1.47568494
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46608504
28POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46373718
29FUS_26573619_Chip-Seq_HEK293_Human1.44987386
30* P300_19829295_ChIP-Seq_ESCs_Human1.44810844
31RNF2_27304074_Chip-Seq_NSC_Mouse1.42372291
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41325783
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38419576
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36660833
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.35360994
36ZNF274_21170338_ChIP-Seq_K562_Hela1.35233366
37SMAD3_21741376_ChIP-Seq_EPCs_Human1.34335872
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.33971037
39KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.33798066
40REST_21632747_ChIP-Seq_MESCs_Mouse1.32114819
41TP63_17297297_ChIP-ChIP_HaCaT_Human1.31967006
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30942939
43PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29670360
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.29087962
45TBX3_20139965_ChIP-Seq_ESCs_Mouse1.28912487
46TBX3_20139965_ChIP-Seq_MESCs_Mouse1.28539650
47HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.28296085
48ISL1_27105846_Chip-Seq_CPCs_Mouse1.25792797
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25669363
50EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24782733
51TRIM28_21343339_ChIP-Seq_HEK293_Human1.23701656
52TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.23570758
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22708431
54* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.22565671
55IGF1R_20145208_ChIP-Seq_DFB_Human1.21706798
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18555313
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18372054
58* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.17711505
59HNF4A_19822575_ChIP-Seq_HepG2_Human1.17298302
60* CJUN_26792858_Chip-Seq_BT549_Human1.15844256
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15784159
62TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15729211
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.13634273
64STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13456076
65BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12428695
66* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12260188
67* EED_16625203_ChIP-ChIP_MESCs_Mouse1.12101148
68GBX2_23144817_ChIP-Seq_PC3_Human1.11456965
69* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.11300389
70* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.11300389
71RING1B_27294783_Chip-Seq_NPCs_Mouse1.10792668
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09864941
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09864941
74SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.09237500
75* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07936755
76SOX9_26525672_Chip-Seq_HEART_Mouse1.07645251
77* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.06216065
78REST_18959480_ChIP-ChIP_MESCs_Mouse1.05932074
79ESR1_21235772_ChIP-Seq_MCF-7_Human1.05862921
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03975673
81AR_25329375_ChIP-Seq_VCAP_Human1.03876454
82SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03602575
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03273663
84AR_21572438_ChIP-Seq_LNCaP_Human1.02435093
85ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02295938
86SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01970072
87* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01258210
88EWS_26573619_Chip-Seq_HEK293_Human1.01141619
89HTT_18923047_ChIP-ChIP_STHdh_Human1.00199963
90CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.00146996
91JARID2_20075857_ChIP-Seq_MESCs_Mouse1.00054427
92LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99291864
93OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98964199
94STAT3_23295773_ChIP-Seq_U87_Human0.98882002
95TP53_16413492_ChIP-PET_HCT116_Human0.98872122
96NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98799211
97NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98799211
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98721958
99ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96546020
100RUNX2_22187159_ChIP-Seq_PCA_Human0.96149065
101PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95444233
102NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95257887
103HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94248122
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94081944
105ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93901433
106MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.93678501
107MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93626925
108ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93476747
109AR_19668381_ChIP-Seq_PC3_Human0.92457687
110SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.92158516
111PIAS1_25552417_ChIP-Seq_VCAP_Human0.91969923
112ESR1_20079471_ChIP-ChIP_T-47D_Human0.89229023
113CDX2_20551321_ChIP-Seq_CACO-2_Human0.88290072
114DROSHA_22980978_ChIP-Seq_HELA_Human0.85384707
115ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85367696
116STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.85207104
117* JARID2_20064375_ChIP-Seq_MESCs_Mouse0.84369698
118EZH2_27294783_Chip-Seq_ESCs_Mouse0.84050369
119AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.83808095
120SUZ12_27294783_Chip-Seq_ESCs_Mouse0.83048525
121BCAT_22108803_ChIP-Seq_LS180_Human0.82590039
122TAF15_26573619_Chip-Seq_HEK293_Human0.79648709
123TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.79136250
124ZNF263_19887448_ChIP-Seq_K562_Human0.78831064
125SMAD4_21741376_ChIP-Seq_HESCs_Human0.77494978
126AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.76969118
127SOX2_27498859_Chip-Seq_STOMACH_Mouse0.76907237
128* LXR_22292898_ChIP-Seq_THP-1_Human0.74057184
129EP300_21415370_ChIP-Seq_HL-1_Mouse0.73143161
130TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.72567255
131* EZH2_27304074_Chip-Seq_ESCs_Mouse0.72282322
132DNAJC2_21179169_ChIP-ChIP_NT2_Human0.71980442
133CDX2_19796622_ChIP-Seq_MESCs_Mouse0.71052707
134RXRA_24833708_ChIP-Seq_LIVER_Mouse0.68793219
135WT1_25993318_ChIP-Seq_PODOCYTE_Human0.67652562
136SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67477545
137SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.67391296
138PPAR_26484153_Chip-Seq_NCI-H1993_Human0.66383227
139ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.65733513
140AUTS2_25519132_ChIP-Seq_293T-REX_Human0.63769884
141GATA4_25053715_ChIP-Seq_YYC3_Human0.63644276
142ARNT_22903824_ChIP-Seq_MCF-7_Human0.63183526
143GATA1_22025678_ChIP-Seq_K562_Human0.61900298
144TP53_18474530_ChIP-ChIP_U2OS_Human0.61875763
145AHR_22903824_ChIP-Seq_MCF-7_Human0.61483648
146SMAD4_21741376_ChIP-Seq_EPCs_Human0.61159332
147TP53_20018659_ChIP-ChIP_R1E_Mouse0.61070538
148RNF2_27304074_Chip-Seq_ESCs_Mouse0.61025287
149* PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.60627741
150EGR1_19032775_ChIP-ChIP_M12_Human0.60579808
151FOXO3_23340844_ChIP-Seq_DLD1_Human0.60340866
152SOX2_21211035_ChIP-Seq_LN229_Gbm0.60059893
153CTBP1_25329375_ChIP-Seq_LNCAP_Human0.59882866
154CTBP2_25329375_ChIP-Seq_LNCAP_Human0.59795762
155RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59634091
156* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.59132884
157CTCF_27219007_Chip-Seq_Bcells_Human0.58577288
158* RING1B_27294783_Chip-Seq_ESCs_Mouse0.58072251
159NR3C1_23031785_ChIP-Seq_PC12_Mouse0.58020765
160NR3C1_21868756_ChIP-Seq_MCF10A_Human0.57144875
161RXR_22108803_ChIP-Seq_LS180_Human0.56955835

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.89081169
2MP0005360_urolithiasis7.61182972
3MP0005085_abnormal_gallbladder_physiolo5.82366377
4MP0005365_abnormal_bile_salt5.66389373
5MP0008875_abnormal_xenobiotic_pharmacok4.77368289
6MP0003252_abnormal_bile_duct3.76695311
7MP0010329_abnormal_lipoprotein_level3.28119073
8MP0003806_abnormal_nucleotide_metabolis3.14725844
9MP0005332_abnormal_amino_acid3.04309569
10MP0010030_abnormal_orbit_morphology2.85539094
11MP0003195_calcinosis2.77649264
12MP0009840_abnormal_foam_cell2.56742820
13MP0004019_abnormal_vitamin_homeostasis2.53600743
14MP0005083_abnormal_biliary_tract2.47759381
15MP0000778_abnormal_nervous_system2.43377900
16MP0001666_abnormal_nutrient_absorption2.23861381
17MP0005503_abnormal_tendon_morphology2.23553230
18MP0002138_abnormal_hepatobiliary_system2.03480293
19MP0001299_abnormal_eye_distance/1.98642042
20MP0005275_abnormal_skin_tensile1.96868567
21* MP0002118_abnormal_lipid_homeostasis1.91825087
22MP0003191_abnormal_cellular_cholesterol1.89471483
23MP0000609_abnormal_liver_physiology1.77715475
24MP0005257_abnormal_intraocular_pressure1.75477067
25MP0003868_abnormal_feces_composition1.75175604
26MP0003880_abnormal_central_pattern1.70505995
27MP0000049_abnormal_middle_ear1.69327673
28MP0000534_abnormal_ureter_morphology1.69265797
29MP0005623_abnormal_meninges_morphology1.67218423
30MP0003941_abnormal_skin_development1.63286595
31MP0003122_maternal_imprinting1.59892321
32* MP0005319_abnormal_enzyme/_coenzyme1.55419639
33MP0002234_abnormal_pharynx_morphology1.55367053
34MP0001529_abnormal_vocalization1.53968255
35MP0008789_abnormal_olfactory_epithelium1.52861972
36* MP0005584_abnormal_enzyme/coenzyme_acti1.49312449
37MP0009643_abnormal_urine_homeostasis1.46035976
38MP0003755_abnormal_palate_morphology1.45591710
39MP0009250_abnormal_appendicular_skeleto1.45473564
40MP0003942_abnormal_urinary_system1.43110218
41MP0009780_abnormal_chondrocyte_physiolo1.43089543
42MP0003279_aneurysm1.41531001
43MP0003385_abnormal_body_wall1.41458235
44MP0002233_abnormal_nose_morphology1.38248610
45MP0003937_abnormal_limbs/digits/tail_de1.37379556
46MP0003283_abnormal_digestive_organ1.33544893
47MP0002938_white_spotting1.29922735
48MP0003705_abnormal_hypodermis_morpholog1.29556337
49MP0005499_abnormal_olfactory_system1.29424975
50MP0005394_taste/olfaction_phenotype1.29424975
51MP0000762_abnormal_tongue_morphology1.27038937
52MP0002102_abnormal_ear_morphology1.25320416
53MP0001984_abnormal_olfaction1.24324192
54MP0004133_heterotaxia1.22797605
55MP0006292_abnormal_olfactory_placode1.22586941
56MP0010368_abnormal_lymphatic_system1.22419015
57MP0002697_abnormal_eye_size1.22022022
58MP0000537_abnormal_urethra_morphology1.21817938
59MP0005636_abnormal_mineral_homeostasis1.17213557
60MP0002184_abnormal_innervation1.16215489
61MP0010386_abnormal_urinary_bladder1.15886311
62MP0004270_analgesia1.15513645
63MP0002751_abnormal_autonomic_nervous1.15432228
64MP0003329_amyloid_beta_deposits1.14698896
65MP0001542_abnormal_bone_strength1.13439890
66MP0003119_abnormal_digestive_system1.12687369
67MP0005647_abnormal_sex_gland1.11345085
68MP0003861_abnormal_nervous_system1.09958378
69MP0009697_abnormal_copulation1.09543353
70MP0005508_abnormal_skeleton_morphology1.08245644
71MP0001764_abnormal_homeostasis1.07865200
72MP0004043_abnormal_pH_regulation1.07748185
73MP0000604_amyloidosis1.07403258
74MP0005423_abnormal_somatic_nervous1.06196847
75MP0000428_abnormal_craniofacial_morphol1.04772544
76MP0003011_delayed_dark_adaptation1.04469726
77MP0000955_abnormal_spinal_cord1.03403390
78MP0002876_abnormal_thyroid_physiology1.02489447
79MP0003935_abnormal_craniofacial_develop1.02459309
80MP0003635_abnormal_synaptic_transmissio1.02365800
81MP0002108_abnormal_muscle_morphology1.01219233
82MP0006072_abnormal_retinal_apoptosis1.01149858
83MP0005451_abnormal_body_composition1.00319721
84MP0003938_abnormal_ear_development1.00196587
85MP0002734_abnormal_mechanical_nocicepti1.00062864
86MP0002116_abnormal_craniofacial_bone0.99639237
87MP0000566_synostosis0.97676865
88MP0001286_abnormal_eye_development0.96943777
89MP0001293_anophthalmia0.96079981
90MP0004142_abnormal_muscle_tone0.95688848
91MP0001756_abnormal_urination0.95606422
92MP0000462_abnormal_digestive_system0.94989443
93MP0005197_abnormal_uvea_morphology0.94160714
94MP0000026_abnormal_inner_ear0.93524880
95MP0002254_reproductive_system_inflammat0.92711049
96MP0005248_abnormal_Harderian_gland0.92289607
97MP0003890_abnormal_embryonic-extraembry0.91969613
98MP0002736_abnormal_nociception_after0.90910884
99MP0000598_abnormal_liver_morphology0.90335001
100MP0003186_abnormal_redox_activity0.89813581
101MP0003121_genomic_imprinting0.88259585
102MP0000751_myopathy0.88185141
103MP0002557_abnormal_social/conspecific_i0.87673132
104MP0009053_abnormal_anal_canal0.87640680
105MP0005084_abnormal_gallbladder_morpholo0.87567881
106MP0002063_abnormal_learning/memory/cond0.87339788
107MP0002752_abnormal_somatic_nervous0.86381223
108MP0002152_abnormal_brain_morphology0.85822742
109MP0004130_abnormal_muscle_cell0.84599495
110MP0009764_decreased_sensitivity_to0.84134548
111MP0003690_abnormal_glial_cell0.83414951
112MP0000432_abnormal_head_morphology0.83180634
113MP0002882_abnormal_neuron_morphology0.82976906
114MP0002572_abnormal_emotion/affect_behav0.82301406
115MP0001486_abnormal_startle_reflex0.82047705
116MP0005535_abnormal_body_temperature0.78769071
117MP0002081_perinatal_lethality0.78405019
118MP0000631_abnormal_neuroendocrine_gland0.78260119
119MP0009745_abnormal_behavioral_response0.77140357
120MP0000427_abnormal_hair_cycle0.77015176
121MP0001879_abnormal_lymphatic_vessel0.76338147
122MP0000767_abnormal_smooth_muscle0.74640226
123* MP0009642_abnormal_blood_homeostasis0.74490780
124MP0002272_abnormal_nervous_system0.74373264
125MP0005187_abnormal_penis_morphology0.70453736
126MP0003656_abnormal_erythrocyte_physiolo0.70059266
127MP0003638_abnormal_response/metabolism_0.68036625
128MP0005220_abnormal_exocrine_pancreas0.67308734
129MP0002136_abnormal_kidney_physiology0.66719456
130MP0002078_abnormal_glucose_homeostasis0.66463693
131MP0005670_abnormal_white_adipose0.66095753
132MP0009384_cardiac_valve_regurgitation0.65359232
133MP0001765_abnormal_ion_homeostasis0.63899435
134MP0001661_extended_life_span0.61782999
135MP0002295_abnormal_pulmonary_circulatio0.61508125
136MP0002971_abnormal_brown_adipose0.61095536
137MP0002168_other_aberrant_phenotype0.60206903
138MP0009763_increased_sensitivity_to0.60014179
139MP0002249_abnormal_larynx_morphology0.58537474
140MP0005167_abnormal_blood-brain_barrier0.57412511
141MP0000639_abnormal_adrenal_gland0.57086202
142MP0002089_abnormal_postnatal_growth/wei0.56327920
143MP0002928_abnormal_bile_duct0.55294946
144MP0005334_abnormal_fat_pad0.54446708
145MP0005408_hypopigmentation0.53641594
146MP0005376_homeostasis/metabolism_phenot0.53062441
147MP0004272_abnormal_basement_membrane0.52765605
148MP0005595_abnormal_vascular_smooth0.52303947
149MP0000230_abnormal_systemic_arterial0.51243993
150MP0003075_altered_response_to0.51089020
151MP0000538_abnormal_urinary_bladder0.50829620
152MP0001958_emphysema0.50403531
153MP0001177_atelectasis0.49975783
154MP0002896_abnormal_bone_mineralization0.48245750
155MP0002837_dystrophic_cardiac_calcinosis0.47650953
156MP0009765_abnormal_xenobiotic_induced0.46311687
157MP0004858_abnormal_nervous_system0.45756913
158MP0002282_abnormal_trachea_morphology0.45360911
159MP0002822_catalepsy0.45088120
160MP0005666_abnormal_adipose_tissue0.45072830
161MP0004885_abnormal_endolymph0.44331104
162* MP0003953_abnormal_hormone_level0.43921137
163MP0004883_abnormal_blood_vessel0.43848008
164MP0006036_abnormal_mitochondrial_physio0.43680434
165MP0000579_abnormal_nail_morphology0.43208005
166MP0005448_abnormal_energy_balance0.43041544
167MP0005395_other_phenotype0.42636236
168MP0008874_decreased_physiological_sensi0.42369811
169MP0008872_abnormal_physiological_respon0.41204259
170MP0008961_abnormal_basal_metabolism0.39162670
171MP0005166_decreased_susceptibility_to0.38809413
172* MP0008469_abnormal_protein_level0.38790162
173MP0006276_abnormal_autonomic_nervous0.38502918
174MP0008438_abnormal_cutaneous_collagen0.36550718
175MP0004859_abnormal_synaptic_plasticity0.36433711
176MP0002135_abnormal_kidney_morphology0.32704678

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.85047726
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.43313827
3Intrahepatic cholestasis (HP:0001406)6.35827650
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.70645351
5Xanthomatosis (HP:0000991)5.69237939
6Prolonged partial thromboplastin time (HP:0003645)5.62797690
7Hypobetalipoproteinemia (HP:0003563)5.13067337
8Hyperlipoproteinemia (HP:0010980)4.80776520
9Complement deficiency (HP:0004431)4.69180553
10Abnormality of glutamine family amino acid metabolism (HP:0010902)4.53439736
11Ketosis (HP:0001946)4.49748971
12Hyperglycinemia (HP:0002154)4.44380249
13Hyperammonemia (HP:0001987)4.41336140
14Hyperglycinuria (HP:0003108)4.38382936
15Abnormality of glycine metabolism (HP:0010895)4.25080348
16Abnormality of serine family amino acid metabolism (HP:0010894)4.25080348
17Epidermoid cyst (HP:0200040)4.03806175
18Hypolipoproteinemia (HP:0010981)4.00439713
19Joint hemorrhage (HP:0005261)3.92499344
20Abnormality of sulfur amino acid metabolism (HP:0004339)3.85532512
21Abnormality of aspartate family amino acid metabolism (HP:0010899)3.81324097
22Abnormality of the common coagulation pathway (HP:0010990)3.72656809
23Hypoalphalipoproteinemia (HP:0003233)3.71875061
24Premature rupture of membranes (HP:0001788)3.68998257
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.57578916
26Ketoacidosis (HP:0001993)3.55924889
27Gout (HP:0001997)3.55504499
28Hypoglycemic coma (HP:0001325)3.45451101
29Abnormality of methionine metabolism (HP:0010901)3.39288131
30Fat malabsorption (HP:0002630)3.37639786
31Broad metatarsal (HP:0001783)3.37622338
32Protrusio acetabuli (HP:0003179)3.30475766
33Abnormality of complement system (HP:0005339)3.28090372
34Conjugated hyperbilirubinemia (HP:0002908)3.28049563
35Abnormality of fatty-acid metabolism (HP:0004359)3.21337133
36Ankle contracture (HP:0006466)3.17437366
37Abnormality of purine metabolism (HP:0004352)3.05588393
38Abnormality of nucleobase metabolism (HP:0010932)3.04847505
39Abnormality of pyrimidine metabolism (HP:0004353)3.03365729
40Vascular calcification (HP:0004934)3.02855356
41Abnormality of dentin (HP:0010299)3.01282411
42Atrophic scars (HP:0001075)3.00895341
43Abnormality of the intrinsic pathway (HP:0010989)2.99098576
44Hypercholesterolemia (HP:0003124)2.94590340
45Coronal craniosynostosis (HP:0004440)2.92602943
46Hepatocellular carcinoma (HP:0001402)2.86520230
47Cardiovascular calcification (HP:0011915)2.82764193
48Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.82465672
49Abnormality of serum amino acid levels (HP:0003112)2.81515102
50* Delayed CNS myelination (HP:0002188)2.77724141
51Shallow orbits (HP:0000586)2.77619271
52Metabolic acidosis (HP:0001942)2.76462860
53Hyperbilirubinemia (HP:0002904)2.74305835
54Soft skin (HP:0000977)2.68703995
55Follicular hyperkeratosis (HP:0007502)2.62756970
56Bladder diverticulum (HP:0000015)2.58101346
57Neonatal onset (HP:0003623)2.57937675
58Spontaneous abortion (HP:0005268)2.57319276
59Abnormality of proline metabolism (HP:0010907)2.43910980
60Hydroxyprolinuria (HP:0003080)2.43910980
61Skin nodule (HP:0200036)2.43625928
62Dicarboxylic aciduria (HP:0003215)2.42774965
63Abnormality of dicarboxylic acid metabolism (HP:0010995)2.42774965
64Enlarged kidneys (HP:0000105)2.42529472
65Mitral stenosis (HP:0001718)2.42179232
66Sensorimotor neuropathy (HP:0007141)2.42154341
67Alkalosis (HP:0001948)2.41392694
68Lethargy (HP:0001254)2.41343778
69Wrist flexion contracture (HP:0001239)2.39894714
70Steatorrhea (HP:0002570)2.39221214
71Esophageal varix (HP:0002040)2.37084550
72Spastic diplegia (HP:0001264)2.33669943
73Hyperuricemia (HP:0002149)2.33135882
74Increased purine levels (HP:0004368)2.33135882
75Neonatal short-limb short stature (HP:0008921)2.31030169
76Proximal tubulopathy (HP:0000114)2.30729417
77Myocardial infarction (HP:0001658)2.30591078
78Aortic dissection (HP:0002647)2.27599984
79Malnutrition (HP:0004395)2.27488167
80Hypoglycemic seizures (HP:0002173)2.23820603
81Hypochromic microcytic anemia (HP:0004840)2.22856954
82Abnormality of the labia minora (HP:0012880)2.22595687
83Rickets (HP:0002748)2.21814288
84Generalized aminoaciduria (HP:0002909)2.18890355
85Wide anterior fontanel (HP:0000260)2.17280670
86* Irritability (HP:0000737)2.13822789
87Systemic lupus erythematosus (HP:0002725)2.12358056
88Morphological abnormality of the middle ear (HP:0008609)2.08553405
89Vascular tortuosity (HP:0004948)2.08134211
90Esophageal atresia (HP:0002032)2.08021226
91Vomiting (HP:0002013)2.07166148
92Hypoventilation (HP:0002791)2.06258957
93Turricephaly (HP:0000262)2.05298599
94Hypophosphatemic rickets (HP:0004912)2.04277421
95Status epilepticus (HP:0002133)2.03670033
96Lymphangioma (HP:0100764)2.03651650
97Hyperventilation (HP:0002883)2.02502854
98Late onset (HP:0003584)2.00039937
99Keratoconus (HP:0000563)1.99829081
100Increased corneal curvature (HP:0100692)1.99829081
101Partial duplication of the phalanx of hand (HP:0009999)1.99476382
102Confusion (HP:0001289)1.98780720
103Bowel diverticulosis (HP:0005222)1.98294869
104Amyloidosis (HP:0011034)1.97785243
105Genu recurvatum (HP:0002816)1.93023849
106Spinal rigidity (HP:0003306)1.92310064
107Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.89805221
108Short 4th metacarpal (HP:0010044)1.89805221
109Aortic aneurysm (HP:0004942)1.88637082
110Abnormal gallbladder morphology (HP:0012437)1.88452688
111Back pain (HP:0003418)1.88271739
112Cholelithiasis (HP:0001081)1.87206012
113Glomerulonephritis (HP:0000099)1.87056815
114Nephrolithiasis (HP:0000787)1.86540170
115Gastrointestinal atresia (HP:0002589)1.85176138
116Pancreatic fibrosis (HP:0100732)1.84378764
117Cerebral edema (HP:0002181)1.84262225
118Abnormal cartilage morphology (HP:0002763)1.83357197
119Preaxial foot polydactyly (HP:0001841)1.81949345
120Glycosuria (HP:0003076)1.80659681
121Abnormality of urine glucose concentration (HP:0011016)1.80659681
122Shawl scrotum (HP:0000049)1.80659540
123Fragile skin (HP:0001030)1.79355162
124Opisthotonus (HP:0002179)1.79106845
125Overgrowth (HP:0001548)1.79046013
126Cholecystitis (HP:0001082)1.78720527
127Abnormal gallbladder physiology (HP:0012438)1.78720527
128Delayed gross motor development (HP:0002194)1.78407173
129Broad long bones (HP:0005622)1.78039541
130Cutaneous finger syndactyly (HP:0010554)1.77649839
131Pancreatitis (HP:0001733)1.77085237
132Abnormality of midbrain morphology (HP:0002418)1.76744510
133Molar tooth sign on MRI (HP:0002419)1.76744510
134Infantile muscular hypotonia (HP:0008947)1.76491362
135Type 1 muscle fiber predominance (HP:0003803)1.76466921
136Hepatoblastoma (HP:0002884)1.76320153
137Abnormal enzyme/coenzyme activity (HP:0012379)1.75673525
138Bifid tongue (HP:0010297)1.75266594
139Buphthalmos (HP:0000557)1.73701230
140Limited hip movement (HP:0008800)1.73627403
141Cutaneous syndactyly (HP:0012725)1.73589873
142Partial duplication of thumb phalanx (HP:0009944)1.69328653
143Arterial tortuosity (HP:0005116)1.67998311
144Acanthocytosis (HP:0001927)1.67200924
145Hypokalemic alkalosis (HP:0001949)1.66838266
146High anterior hairline (HP:0009890)1.66300320
147Thrombophlebitis (HP:0004418)1.66190376
148Hyperactive renin-angiotensin system (HP:0000841)1.66140505
149Abnormality of the gallbladder (HP:0005264)1.65791729
150Abnormality of the lower motor neuron (HP:0002366)1.65103300
151Septo-optic dysplasia (HP:0100842)1.64899879
152* Abnormality of the antihelix (HP:0009738)1.64170281
153Labial hypoplasia (HP:0000066)1.61911860
154Renal dysplasia (HP:0000110)1.61550245
155Trigonocephaly (HP:0000243)1.60984340
156Mild short stature (HP:0003502)1.59049932
157Retinal dysplasia (HP:0007973)1.57066778
158Narrow nasal bridge (HP:0000446)1.55258112
159Calcaneovalgus deformity (HP:0001848)1.55039968
160Intellectual disability, moderate (HP:0002342)1.54556952
161Wormian bones (HP:0002645)1.54489625
162Anterior segment dysgenesis (HP:0007700)1.54245994
163Hip contracture (HP:0003273)1.53572019
164Vaginal atresia (HP:0000148)1.53229115
165Aplasia involving bones of the upper limbs (HP:0009823)1.52904517
166Aplasia of the phalanges of the hand (HP:0009802)1.52904517
167Aplasia involving bones of the extremities (HP:0009825)1.52904517
168Broad phalanx (HP:0006009)1.52813618
169Genital tract atresia (HP:0001827)1.52705487
170Deformed tarsal bones (HP:0008119)1.52498024
171Abnormality of the diencephalon (HP:0010662)1.52372067
172Nephronophthisis (HP:0000090)1.51453315
173Optic nerve hypoplasia (HP:0000609)1.51273085
174Fragile nails (HP:0001808)1.50595037
175Abnormality of the 4th metacarpal (HP:0010012)1.50128343
176Hypoplastic ischia (HP:0003175)1.49523739
177Hyperextensible skin (HP:0000974)1.49514098
178Ulnar bowing (HP:0003031)1.48407271
179Aplasia/Hypoplasia of the tongue (HP:0010295)1.48208846
180Aplasia/Hypoplasia of the hallux (HP:0008362)1.48163033
181Megalencephaly (HP:0001355)1.47137534
182* Drooling (HP:0002307)1.47115039
183Occipital encephalocele (HP:0002085)1.46818650
184Gait imbalance (HP:0002141)1.46633520
185Split foot (HP:0001839)1.46331474
186Myokymia (HP:0002411)1.45293093
187Postaxial hand polydactyly (HP:0001162)1.44861028
188Lissencephaly (HP:0001339)1.44576085
189Short hallux (HP:0010109)1.44398664
190Micropenis (HP:0000054)1.44192074
191Pachygyria (HP:0001302)1.44050267
192* Narrow forehead (HP:0000341)1.43549633
193Hypoplastic female external genitalia (HP:0012815)1.43092169
194Slender build (HP:0001533)1.41973922
195Synostosis involving bones of the feet (HP:0009140)1.41664085
196Synostosis involving bones of the lower limbs (HP:0009138)1.41664085
197Broad finger (HP:0001500)1.41455714

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.01608595
2SIK13.83697916
3CASK3.30140553
4ERN13.07898196
5FGFR43.01315330
6PNCK2.91008678
7MARK12.51024953
8EPHA42.28805112
9DAPK22.24813294
10WNK32.17605228
11MAP2K42.12497079
12TRIB32.11534712
13FGFR22.06437186
14INSRR1.98760968
15LATS11.82051093
16MYLK1.79956433
17ERBB41.79543890
18WNK41.76948520
19TIE11.72626700
20LATS21.68407560
21BMPR1B1.57704562
22EPHB21.56673273
23PKN21.56387602
24MAP4K21.50587244
25AKT31.50291580
26BCR1.44128985
27MST1R1.42747458
28MAP3K71.33820017
29PHKG11.30481965
30PHKG21.30481965
31STK38L1.30033574
32LMTK21.28144941
33TGFBR11.27706335
34PTK61.25422649
35MAPK131.24494343
36PRKCZ1.23091012
37PLK21.22323162
38TNIK1.18031672
39LIMK11.15170155
40PRKD31.15161268
41OXSR11.12108348
42FER1.10503353
43PRKCE1.09924862
44MAPK121.08177663
45CAMK1D1.05203102
46MINK11.04779677
47CAMK1G1.04624395
48FRK1.03580921
49MAP3K91.03403306
50PAK21.01517135
51NTRK21.01106814
52TRIM281.00795646
53KSR11.00009338
54SGK2230.98230286
55SGK4940.98230286
56SGK30.97743546
57RIPK10.97095262
58MAPK110.95305216
59NTRK10.94781740
60FGFR30.94273455
61ERBB20.93335876
62PAK30.93256539
63ABL20.92957140
64CDK80.92796630
65PDGFRA0.92614745
66ADRBK20.90541310
67MAP3K40.90448446
68TAF10.89943510
69SGK20.88157941
70PRKAA20.84932503
71PTK20.84760681
72TAOK30.84455039
73GRK10.84406642
74RET0.84052047
75FGFR10.83849828
76PRKCG0.81776460
77DYRK30.79516981
78ADRBK10.78618337
79DDR20.77116671
80VRK20.76890312
81STK380.75758304
82CSNK1G10.75408531
83NTRK30.74989438
84ROCK20.74017551
85RPS6KA20.73866585
86MAPK40.72982198
87PINK10.72887870
88GSK3A0.72425793
89PLK30.71460886
90CSNK1A1L0.70087897
91KSR20.69752799
92CSNK1G30.68933165
93PIK3CG0.66927219
94DMPK0.64840696
95PRKACG0.63680588
96ZAK0.63460464
97FLT30.63367986
98KDR0.63362781
99MAP3K20.63023228
100BMX0.62026468
101PTK2B0.61731321
102PRKAA10.61406417
103EPHA30.61061869
104PDK30.61047651
105PDK40.61047651
106JAK20.60613271
107MAPK150.60412560
108TSSK60.60199492
109PAK60.58169951
110PRKD20.57619925
111MAP2K10.57121511
112CSNK1G20.56925184
113TAOK20.56433085
114DAPK10.55748178
115TYRO30.55687280
116CDK180.55624628
117DYRK1A0.55618999
118TGFBR20.55123035
119ERBB30.54730274
120CAMKK10.54401312
121CDK150.54130613
122CAMK2B0.53774363
123UHMK10.53363849
124MET0.53114920
125ILK0.52599989
126CAMK2A0.51591094
127CAMK10.50890449
128ICK0.50508454
129SIK20.50462239
130CDK140.50281399
131CAMK40.50246316
132MAP2K60.50094461
133NEK90.49850234
134CDK11A0.49411649
135NUAK10.48571093
136MAPK70.46630632
137GRK60.46174239
138GRK50.46027492
139EPHB10.45221819
140PRKG10.44947799
141PDPK10.43688384
142STK160.43320476
143IGF1R0.43270200
144PKN10.42943372
145DYRK1B0.42568223
146MTOR0.42164510
147MAP3K120.42103330
148CDK90.41917066
149MAP3K100.41548275
150CAMK2G0.41234979
151PLK40.40735494
152DYRK20.40434062
153MAP2K70.39331866
154ROCK10.39263097
155CDK50.38854803

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.15169239
2Nitrogen metabolism_Homo sapiens_hsa009103.60211706
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.27988468
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.19009582
5Arginine biosynthesis_Homo sapiens_hsa002202.88750929
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.82686508
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.68446744
8Fatty acid degradation_Homo sapiens_hsa000712.62135717
9Tryptophan metabolism_Homo sapiens_hsa003802.59271239
10Butanoate metabolism_Homo sapiens_hsa006502.54917220
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.54274080
12Complement and coagulation cascades_Homo sapiens_hsa046102.39600435
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.32740567
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.20940738
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.18990101
16Propanoate metabolism_Homo sapiens_hsa006402.12286827
17Peroxisome_Homo sapiens_hsa041462.07373565
18Fatty acid metabolism_Homo sapiens_hsa012122.02174015
19PPAR signaling pathway_Homo sapiens_hsa033201.93869592
20ECM-receptor interaction_Homo sapiens_hsa045121.93631329
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.88692193
22Bile secretion_Homo sapiens_hsa049761.82414639
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.78021120
24Hedgehog signaling pathway_Homo sapiens_hsa043401.71911132
25Chemical carcinogenesis_Homo sapiens_hsa052041.70281629
26beta-Alanine metabolism_Homo sapiens_hsa004101.67354604
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.66853603
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.64659321
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.63355751
30Histidine metabolism_Homo sapiens_hsa003401.60867916
31Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.52165016
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.51727306
33Hippo signaling pathway_Homo sapiens_hsa043901.46998881
34Pyruvate metabolism_Homo sapiens_hsa006201.45970757
35Retinol metabolism_Homo sapiens_hsa008301.45933702
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.42855354
37Phenylalanine metabolism_Homo sapiens_hsa003601.36202769
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.35125514
39Tyrosine metabolism_Homo sapiens_hsa003501.34149957
40Sulfur metabolism_Homo sapiens_hsa009201.33978295
41Caffeine metabolism_Homo sapiens_hsa002321.31677984
42Nicotine addiction_Homo sapiens_hsa050331.31138256
43Selenocompound metabolism_Homo sapiens_hsa004501.28401276
44Staphylococcus aureus infection_Homo sapiens_hsa051501.26123857
45Starch and sucrose metabolism_Homo sapiens_hsa005001.24001829
46Protein export_Homo sapiens_hsa030601.20549846
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.19034962
48Fatty acid elongation_Homo sapiens_hsa000621.18510525
49Dilated cardiomyopathy_Homo sapiens_hsa054141.13671182
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12880248
51Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.12184847
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11106178
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09512271
54Steroid biosynthesis_Homo sapiens_hsa001001.08621904
55Carbon metabolism_Homo sapiens_hsa012001.08052392
56Cocaine addiction_Homo sapiens_hsa050301.06267735
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.01964757
58ABC transporters_Homo sapiens_hsa020101.00956221
59Cardiac muscle contraction_Homo sapiens_hsa042601.00147150
60Biosynthesis of amino acids_Homo sapiens_hsa012300.99759573
61Glutamatergic synapse_Homo sapiens_hsa047240.99690490
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.99003987
63Vitamin digestion and absorption_Homo sapiens_hsa049770.96165615
64Wnt signaling pathway_Homo sapiens_hsa043100.94773099
65Focal adhesion_Homo sapiens_hsa045100.94682201
66Fat digestion and absorption_Homo sapiens_hsa049750.94091474
67Arginine and proline metabolism_Homo sapiens_hsa003300.92890804
68Lysine degradation_Homo sapiens_hsa003100.92002219
69Melanogenesis_Homo sapiens_hsa049160.90138305
70TGF-beta signaling pathway_Homo sapiens_hsa043500.89240637
71Dopaminergic synapse_Homo sapiens_hsa047280.88468192
72Tight junction_Homo sapiens_hsa045300.87072764
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86162631
74Circadian entrainment_Homo sapiens_hsa047130.85825658
75Gap junction_Homo sapiens_hsa045400.83741852
76Insulin secretion_Homo sapiens_hsa049110.83496008
77Phototransduction_Homo sapiens_hsa047440.77673120
78Morphine addiction_Homo sapiens_hsa050320.77446719
79Folate biosynthesis_Homo sapiens_hsa007900.75638276
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72165580
81Serotonergic synapse_Homo sapiens_hsa047260.72141326
82Fatty acid biosynthesis_Homo sapiens_hsa000610.70032022
83Glycerolipid metabolism_Homo sapiens_hsa005610.67799044
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.67759966
85Adherens junction_Homo sapiens_hsa045200.67177622
86Melanoma_Homo sapiens_hsa052180.65328660
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64003758
88Oxidative phosphorylation_Homo sapiens_hsa001900.60464057
89Sulfur relay system_Homo sapiens_hsa041220.60214144
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59985428
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59065199
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58271425
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58192068
94Glutathione metabolism_Homo sapiens_hsa004800.56072173
95PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55539673
96Vitamin B6 metabolism_Homo sapiens_hsa007500.54574364
97Cholinergic synapse_Homo sapiens_hsa047250.54574288
98Parkinsons disease_Homo sapiens_hsa050120.51235905
99Amphetamine addiction_Homo sapiens_hsa050310.50314254
100Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48988566
101Proteoglycans in cancer_Homo sapiens_hsa052050.48347604
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46430943
103Prion diseases_Homo sapiens_hsa050200.45703557
104cAMP signaling pathway_Homo sapiens_hsa040240.44937159
105Basal transcription factors_Homo sapiens_hsa030220.44341066
106Huntingtons disease_Homo sapiens_hsa050160.43505306
107Alzheimers disease_Homo sapiens_hsa050100.42793720
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40023186
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39180433
110Metabolic pathways_Homo sapiens_hsa011000.34296057
111Insulin resistance_Homo sapiens_hsa049310.32742531
112Thyroid hormone synthesis_Homo sapiens_hsa049180.29068632
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.28680419
114Pentose phosphate pathway_Homo sapiens_hsa000300.27638401
115Glucagon signaling pathway_Homo sapiens_hsa049220.27199995
116AMPK signaling pathway_Homo sapiens_hsa041520.14449986
117Fructose and mannose metabolism_Homo sapiens_hsa000510.14060592
118Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.13967158
119One carbon pool by folate_Homo sapiens_hsa006700.12724483
120Ovarian steroidogenesis_Homo sapiens_hsa049130.12700117
121Galactose metabolism_Homo sapiens_hsa000520.10467019
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.09069739
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.08835494
124Protein digestion and absorption_Homo sapiens_hsa049740.07378603
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.06420553
126Insulin signaling pathway_Homo sapiens_hsa049100.03527831
127Mineral absorption_Homo sapiens_hsa049780.03139683
128Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.03076216
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.00613490
130GABAergic synapse_Homo sapiens_hsa047270.00187812
131Amoebiasis_Homo sapiens_hsa05146-0.1120914
132Axon guidance_Homo sapiens_hsa04360-0.1033722
133Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524-0.0953072
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0935637
135Linoleic acid metabolism_Homo sapiens_hsa00591-0.0896566
136Gastric acid secretion_Homo sapiens_hsa04971-0.0883080
137Bladder cancer_Homo sapiens_hsa05219-0.0859467
138Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0741491
139Basal cell carcinoma_Homo sapiens_hsa05217-0.0667445
140Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0503645
141Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0492694
142Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0375522
143Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.0249759

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