SLC16A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)5.35021174
2embryonic process involved in female pregnancy (GO:0060136)5.07903653
3regulation of gene silencing by RNA (GO:0060966)4.62588527
4regulation of posttranscriptional gene silencing (GO:0060147)4.62588527
5regulation of gene silencing by miRNA (GO:0060964)4.62588527
6regulation of translational fidelity (GO:0006450)4.54839873
7establishment of apical/basal cell polarity (GO:0035089)4.28583328
8regulation of integrin activation (GO:0033623)4.24829038
9protein localization to endosome (GO:0036010)4.18096859
10response to peptidoglycan (GO:0032494)4.02272503
11pre-miRNA processing (GO:0031054)3.97405166
12barbed-end actin filament capping (GO:0051016)3.97337393
13transcription from mitochondrial promoter (GO:0006390)3.96388384
14negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.96290371
15replication fork processing (GO:0031297)3.91572462
16formation of translation preinitiation complex (GO:0001731)3.91237563
17apoptotic process involved in morphogenesis (GO:0060561)3.86791739
18pinocytosis (GO:0006907)3.85777380
19mitotic G1 DNA damage checkpoint (GO:0031571)3.84136750
20positive regulation by symbiont of host defense response (GO:0052509)3.72253561
21modulation by symbiont of host defense response (GO:0052031)3.72253561
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.72253561
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.72253561
24positive regulation by organism of defense response of other organism involved in symbiotic interact3.72253561
25modulation by symbiont of host immune response (GO:0052553)3.72253561
26heterochromatin organization (GO:0070828)3.71806798
27DNA unwinding involved in DNA replication (GO:0006268)3.71657797
28maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.69872106
29mitochondrial DNA metabolic process (GO:0032042)3.68052038
30IMP biosynthetic process (GO:0006188)3.56401883
31positive regulation of protein homooligomerization (GO:0032464)3.55482733
32somatic hypermutation of immunoglobulin genes (GO:0016446)3.54790968
33somatic diversification of immune receptors via somatic mutation (GO:0002566)3.54790968
34nodal signaling pathway (GO:0038092)3.53828021
35spliceosomal tri-snRNP complex assembly (GO:0000244)3.53412541
36establishment or maintenance of monopolar cell polarity (GO:0061339)3.51050102
37establishment of monopolar cell polarity (GO:0061162)3.51050102
38skin morphogenesis (GO:0043589)3.50482857
39DNA strand elongation involved in DNA replication (GO:0006271)3.50388321
40telomere maintenance via semi-conservative replication (GO:0032201)3.49405509
41negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.48214490
42folic acid-containing compound biosynthetic process (GO:0009396)3.47193973
43trophectodermal cell differentiation (GO:0001829)3.47044926
44mitotic nuclear envelope disassembly (GO:0007077)3.46648106
45positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.42976315
46DNA deamination (GO:0045006)3.42933041
47base-excision repair (GO:0006284)3.42465903
48dosage compensation (GO:0007549)3.39853065
49DNA strand renaturation (GO:0000733)3.39285953
50positive regulation of mitotic sister chromatid separation (GO:1901970)3.38660007
51positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.38660007
52positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.38660007
53negative regulation of interleukin-12 production (GO:0032695)3.33230644
54negative regulation of cell cycle arrest (GO:0071157)3.33140412
55mitotic G1/S transition checkpoint (GO:0044819)3.31765695
56proline metabolic process (GO:0006560)3.30686322
57detection of molecule of bacterial origin (GO:0032490)3.29152026
58DNA strand elongation (GO:0022616)3.27321635
59mitotic sister chromatid segregation (GO:0000070)3.26937503
60positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.24618215
61IMP metabolic process (GO:0046040)3.24478179
62G1 DNA damage checkpoint (GO:0044783)3.23508652
63macrophage activation involved in immune response (GO:0002281)3.23253203
64membrane disassembly (GO:0030397)3.22721741
65nuclear envelope disassembly (GO:0051081)3.22721741
66positive regulation of chromosome segregation (GO:0051984)3.20854136
67neutrophil activation involved in immune response (GO:0002283)3.16058543
68mRNA cleavage (GO:0006379)3.15607660
69embryonic placenta development (GO:0001892)3.15379251
70lipopolysaccharide-mediated signaling pathway (GO:0031663)3.14830720
71apoptotic cell clearance (GO:0043277)3.14769258
72positive regulation of SMAD protein import into nucleus (GO:0060391)3.13611887
73regulation of sister chromatid cohesion (GO:0007063)3.10267582
74protein localization to kinetochore (GO:0034501)3.10188305
75hypotonic response (GO:0006971)3.07182197
76peptidyl-arginine omega-N-methylation (GO:0035247)3.06716034
77nuclear pore organization (GO:0006999)3.05902221
78positive regulation of extracellular matrix organization (GO:1903055)3.04650409
79low-density lipoprotein particle clearance (GO:0034383)3.03431262
80nucleotide-excision repair, DNA gap filling (GO:0006297)3.00885630
81Golgi transport vesicle coating (GO:0048200)3.00865607
82COPI coating of Golgi vesicle (GO:0048205)3.00865607
83negative regulation of mRNA processing (GO:0050686)3.00501130
84glycosphingolipid catabolic process (GO:0046479)3.00159606
85negative regulation of RNA splicing (GO:0033119)2.98921088
86cell adhesion mediated by integrin (GO:0033627)2.97489393
87histone arginine methylation (GO:0034969)2.96881215
88negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.95461395
89negative regulation of cell killing (GO:0031342)2.95461395
90hemidesmosome assembly (GO:0031581)2.95093447
91mannose metabolic process (GO:0006013)2.94909855
92oligosaccharide catabolic process (GO:0009313)2.93240745
93oxidative demethylation (GO:0070989)2.91119578
94basement membrane organization (GO:0071711)2.90864198
95telomere maintenance via recombination (GO:0000722)2.90471064
96regulation of leukocyte degranulation (GO:0043300)2.89746581
97stress fiber assembly (GO:0043149)2.88542956
98endodermal cell differentiation (GO:0035987)2.88256015
99response to laminar fluid shear stress (GO:0034616)2.88250007
100sister chromatid segregation (GO:0000819)2.86990883
101regulation of early endosome to late endosome transport (GO:2000641)2.86324284
102NIK/NF-kappaB signaling (GO:0038061)2.85611354
103apoptotic process involved in development (GO:1902742)2.84503729
104termination of RNA polymerase II transcription (GO:0006369)2.84358692
105regulation of hippo signaling (GO:0035330)2.83664850
106regulation of mast cell degranulation (GO:0043304)2.82387439
107nuclear envelope organization (GO:0006998)2.80008977
108regulation of protein homooligomerization (GO:0032462)2.78853953
109DNA duplex unwinding (GO:0032508)2.78334683
110antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.78105589
111DNA geometric change (GO:0032392)2.77916677
112regulation of superoxide anion generation (GO:0032928)2.77814340
113regulation of myeloid leukocyte mediated immunity (GO:0002886)2.77197714
114viral mRNA export from host cell nucleus (GO:0046784)2.76377908
115detection of external biotic stimulus (GO:0098581)2.75821650
116cellular extravasation (GO:0045123)2.74473968
117regulation of RNA export from nucleus (GO:0046831)2.73744688
118nuclear pore complex assembly (GO:0051292)2.73472953
119intracellular estrogen receptor signaling pathway (GO:0030520)2.72321298
120paraxial mesoderm development (GO:0048339)2.71912107
121positive regulation of protein oligomerization (GO:0032461)2.70564913
122DNA replication initiation (GO:0006270)2.69707700
123hyaluronan catabolic process (GO:0030214)2.68339005
124positive regulation of Cdc42 GTPase activity (GO:0043089)2.66452932
125regulation of protein heterodimerization activity (GO:0043497)2.66261797
126response to muramyl dipeptide (GO:0032495)2.66257122
127antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.65461907
128negative regulation of JAK-STAT cascade (GO:0046426)2.64145726
129regulation of podosome assembly (GO:0071801)2.63732837
130DNA replication-dependent nucleosome organization (GO:0034723)2.63720091
131DNA replication-dependent nucleosome assembly (GO:0006335)2.63720091
132modulation by symbiont of host cellular process (GO:0044068)2.63449664
133mitotic recombination (GO:0006312)2.62989891
134glycolipid catabolic process (GO:0019377)2.62951997
135detection of other organism (GO:0098543)2.62382912
136negative regulation of histone methylation (GO:0031061)2.62250425
137glucose 6-phosphate metabolic process (GO:0051156)2.62156997
138meiotic chromosome segregation (GO:0045132)2.62080849
139regulation of SMAD protein import into nucleus (GO:0060390)2.61068891
140regulation of histone H3-K9 methylation (GO:0051570)2.60772846
141decidualization (GO:0046697)2.60640118
142peptidyl-proline hydroxylation (GO:0019511)2.60452180
143antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.58873570
144negative regulation of mRNA metabolic process (GO:1903312)2.58574790
145positive regulation of leukocyte degranulation (GO:0043302)2.58539644
146regulation of DNA damage checkpoint (GO:2000001)2.58483208
147regulation of double-strand break repair via homologous recombination (GO:0010569)2.57632181
148cell-substrate junction assembly (GO:0007044)2.56563509
149amino sugar catabolic process (GO:0046348)2.56112373
150translational initiation (GO:0006413)2.55440403
151telomere maintenance via telomere lengthening (GO:0010833)2.55353040
152myeloid dendritic cell differentiation (GO:0043011)2.54704422
153negative regulation of myeloid cell apoptotic process (GO:0033033)2.54189668
154substrate-dependent cell migration (GO:0006929)2.53773582
155regulation of mast cell activation involved in immune response (GO:0033006)2.53405261
156maternal placenta development (GO:0001893)2.52252021
157nuclear envelope reassembly (GO:0031468)2.52239070
158mitotic nuclear envelope reassembly (GO:0007084)2.52239070
159cellular response to thyroid hormone stimulus (GO:0097067)2.51709773
160regulation of double-strand break repair (GO:2000779)2.51654908
161protein localization to chromosome, centromeric region (GO:0071459)2.51233620
162regulation of membrane protein ectodomain proteolysis (GO:0051043)2.50640105
163positive regulation of T cell apoptotic process (GO:0070234)2.50196902
164antigen processing and presentation of endogenous antigen (GO:0019883)2.50045468
165regulation of extracellular matrix disassembly (GO:0010715)2.49497554
166regulation of interferon-beta biosynthetic process (GO:0045357)2.49303627
167positive regulation of phagocytosis (GO:0050766)2.47767327
168regulation of T-helper 2 cell differentiation (GO:0045628)2.47680678
169response to host (GO:0075136)2.47435005
170response to host defenses (GO:0052200)2.47435005
171response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.47435005
172protein hydroxylation (GO:0018126)2.47320068
173regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.46942501
174T-helper 1 type immune response (GO:0042088)2.45666369
175detection of bacterium (GO:0016045)2.44499344
176positive regulation of receptor recycling (GO:0001921)2.43804782
177negative regulation of erythrocyte differentiation (GO:0045647)2.42557862
178respiratory burst (GO:0045730)2.42364365
179response to progesterone (GO:0032570)2.40765658
180cortical actin cytoskeleton organization (GO:0030866)2.38918969
181adhesion of symbiont to host (GO:0044406)2.37794799
182macrophage differentiation (GO:0030225)2.37625403
183regulation of macrophage chemotaxis (GO:0010758)2.37456713
184maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.36898049
185regulation of cholesterol storage (GO:0010885)2.36562643
186detection of biotic stimulus (GO:0009595)2.35963042
187protein retention in ER lumen (GO:0006621)2.35514325
188germinal center formation (GO:0002467)2.35111096
189response to thyroid hormone (GO:0097066)2.34831884
190negative regulation of cytokine production involved in immune response (GO:0002719)2.33659966
191membrane raft organization (GO:0031579)2.32984976
192regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.32948464
193positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.32396170
194venous blood vessel morphogenesis (GO:0048845)2.31319311
195granulocyte activation (GO:0036230)2.30486145
196dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.27593628
197regulation of cholesterol homeostasis (GO:2000188)2.26626558
198regulation of phagocytosis (GO:0050764)2.26403532

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.62412712
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.62063267
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.22651571
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.12212840
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.08830322
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.52992319
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.51750427
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.38354821
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.38354821
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.38354821
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.34080654
12* VDR_21846776_ChIP-Seq_THP-1_Human2.32643223
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.31356279
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.30526054
15MYC_22102868_ChIP-Seq_BL_Human2.28535371
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.24030187
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.23330216
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.19444758
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.15306620
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.12720904
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.10288834
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.08775187
23* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.06651601
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.04244277
25* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.00924093
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.97713644
27NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.96481350
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.92905439
29HIF1A_21447827_ChIP-Seq_MCF-7_Human1.91512360
30IRF8_22096565_ChIP-ChIP_GC-B_Human1.90336571
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89569268
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.88029061
33MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.85324480
34IRF8_21731497_ChIP-ChIP_J774_Mouse1.80306614
35RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.79278031
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.77392179
37KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.77033757
38ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.76491438
39DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.75530256
40STAT3_1855785_ChIP-Seq_MESCs_Mouse1.71616977
41CLOCK_20551151_ChIP-Seq_293T_Human1.71573921
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.69553686
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.68764573
44XRN2_22483619_ChIP-Seq_HELA_Human1.66621383
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.65409904
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61367513
47TCF3_18692474_ChIP-Seq_MEFs_Mouse1.59820664
48PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.58477923
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.58346124
50RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.58240549
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.54979292
52ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.53253295
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.52856696
54* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.48448720
55Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.48416801
56SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.45340163
57ESR1_15608294_ChIP-ChIP_MCF-7_Human1.44637710
58SPI1_23127762_ChIP-Seq_K562_Human1.44065921
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.42792090
60* ELK3_25401928_ChIP-Seq_HUVEC_Human1.41628584
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41373198
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41186125
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.40398127
64KDM2B_26808549_Chip-Seq_K562_Human1.40335508
65* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.38961858
66LXR_22292898_ChIP-Seq_THP-1_Human1.38508809
67* KDM2B_26808549_Chip-Seq_DND41_Human1.37390142
68STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37153573
69* TP53_22127205_ChIP-Seq_IMR90_Human1.35608224
70STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.35513404
71SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.34901917
72TCF3_18692474_ChIP-Seq_MESCs_Mouse1.34664939
73NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.33922172
74NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33568751
75MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32132607
76POU5F1_16518401_ChIP-PET_MESCs_Mouse1.31279369
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30800923
78TRIM28_21343339_ChIP-Seq_HEK293_Human1.30558514
79UBF1/2_26484160_Chip-Seq_HMECs_Human1.28974762
80KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.28592131
81ETS1_20019798_ChIP-Seq_JURKAT_Human1.28344763
82ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28092309
83NANOG_21062744_ChIP-ChIP_HESCs_Human1.27189145
84* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26942791
85NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.26665773
86E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26253285
87CTCF_27219007_Chip-Seq_ERYTHROID_Human1.25495593
88POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25447234
89* RACK7_27058665_Chip-Seq_MCF-7_Human1.25394506
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25054159
91TTF2_22483619_ChIP-Seq_HELA_Human1.25028752
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23867845
93CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23839388
94TFEB_21752829_ChIP-Seq_HELA_Human1.23390246
95MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.22890424
96TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22847414
97RXR_22158963_ChIP-Seq_LIVER_Mouse1.22803799
98SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.22610629
99TCF7_22412390_ChIP-Seq_EML_Mouse1.22318113
100* SPI1_23547873_ChIP-Seq_NB4_Human1.22245616
101* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21510747
102KDM5A_27292631_Chip-Seq_BREAST_Human1.21071676
103PPARA_22158963_ChIP-Seq_LIVER_Mouse1.21013320
104MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20079412
105SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.19703533
106* MAF_26560356_Chip-Seq_TH1_Human1.19106519
107TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18932343
108* KDM2B_26808549_Chip-Seq_JURKAT_Human1.18541974
109CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.18227611
110DCP1A_22483619_ChIP-Seq_HELA_Human1.17749704
111GATA2_21666600_ChIP-Seq_HMVEC_Human1.17267506
112SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15393389
113SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.15254622
114SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.15254622
115TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14729913
116GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14580609
117ZNF263_19887448_ChIP-Seq_K562_Human1.14303702
118GATA1_19941827_ChIP-Seq_MEL_Mouse1.14268980
119VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14181154
120HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13708030
121GABP_19822575_ChIP-Seq_HepG2_Human1.13521288
122OCT4_18692474_ChIP-Seq_MEFs_Mouse1.12982091
123P68_20966046_ChIP-Seq_HELA_Human1.12762855
124* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12250194
125KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11869420
126* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11777522
127SA1_27219007_Chip-Seq_ERYTHROID_Human1.11675896
128P63_26484246_Chip-Seq_KERATINOCYTES_Human1.11204786
129EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10848403
130AR_21909140_ChIP-Seq_LNCAP_Human1.10843472
131* ATF3_27146783_Chip-Seq_COLON_Human1.10044977
132BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09533221
133BCOR_27268052_Chip-Seq_Bcells_Human1.09110013
134* NCOR1_26117541_ChIP-Seq_K562_Human1.08462827
135NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.08389169
136JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.08281210
137TET1_21451524_ChIP-Seq_MESCs_Mouse1.07562815
138KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07395807
139KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06712825
140PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06427687
141SOX2_18692474_ChIP-Seq_MEFs_Mouse1.06384657
142* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05914031
143THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05279558
144* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05276321
145ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05006069
146POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04955722
147PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.04742768
148SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04310449
149* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04076832
150* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04076613
151TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03952773
152EST1_17652178_ChIP-ChIP_JURKAT_Human1.03092013
153* UTX_26944678_Chip-Seq_JUKART_Human1.02707369
154ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02610624
155* VDR_24763502_ChIP-Seq_THP-1_Human1.02599749
156SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01896268
157CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01740432
158* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01307824
159* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01073231
160* MAF_26560356_Chip-Seq_TH2_Human1.00041919
161SMC4_20622854_ChIP-Seq_HELA_Human0.99738243
162BCL6_27268052_Chip-Seq_Bcells_Human0.99361888
163ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.98993278
164CREB1_15753290_ChIP-ChIP_HEK293T_Human0.97849409
165* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97532262
166SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97411074
167SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96045922
168P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95785596
169SOX2_18692474_ChIP-Seq_MESCs_Mouse0.95600880

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009278_abnormal_bone_marrow3.50667481
2MP0008057_abnormal_DNA_replication3.28316757
3MP0010030_abnormal_orbit_morphology3.16931336
4MP0009840_abnormal_foam_cell3.01317072
5MP0005076_abnormal_cell_differentiation2.86211557
6MP0005451_abnormal_body_composition2.77355306
7MP0003191_abnormal_cellular_cholesterol2.74970330
8MP0010352_gastrointestinal_tract_polyps2.57704531
9MP0010094_abnormal_chromosome_stability2.56818400
10MP0004957_abnormal_blastocyst_morpholog2.55751615
11MP0003111_abnormal_nucleus_morphology2.53140386
12MP0004233_abnormal_muscle_weight2.40367703
13MP0002877_abnormal_melanocyte_morpholog2.37625613
14MP0005257_abnormal_intraocular_pressure2.31905103
15MP0003300_gastrointestinal_ulcer2.31856027
16MP0003077_abnormal_cell_cycle2.20813506
17MP0003693_abnormal_embryo_hatching2.19724972
18MP0003705_abnormal_hypodermis_morpholog2.15451253
19MP0002419_abnormal_innate_immunity2.15262953
20MP0010307_abnormal_tumor_latency2.08647058
21MP0008260_abnormal_autophagy2.04623522
22MP0003303_peritoneal_inflammation1.98348495
23MP0004510_myositis1.95164358
24MP0002653_abnormal_ependyma_morphology1.93181668
25MP0001533_abnormal_skeleton_physiology1.89486612
26MP0001730_embryonic_growth_arrest1.84821283
27MP0003091_abnormal_cell_migration1.84800900
28MP0003566_abnormal_cell_adhesion1.83326120
29MP0003567_abnormal_fetal_cardiomyocyte1.81371813
30MP0003279_aneurysm1.78058829
31MP0005171_absent_coat_pigmentation1.77942049
32MP0002998_abnormal_bone_remodeling1.77407239
33MP0002148_abnormal_hypersensitivity_rea1.76548741
34MP0008932_abnormal_embryonic_tissue1.76276630
35MP0003890_abnormal_embryonic-extraembry1.73693433
36MP0009785_altered_susceptibility_to1.73229048
37MP0003075_altered_response_to1.72120614
38MP0001697_abnormal_embryo_size1.71784904
39MP0000350_abnormal_cell_proliferation1.71183255
40MP0004197_abnormal_fetal_growth/weight/1.70479280
41MP0004272_abnormal_basement_membrane1.66995884
42MP0000604_amyloidosis1.65739723
43MP0005025_abnormal_response_to1.65541235
44MP0002086_abnormal_extraembryonic_tissu1.64987397
45MP0005464_abnormal_platelet_physiology1.64632139
46MP0006054_spinal_hemorrhage1.64096962
47MP0003724_increased_susceptibility_to1.62691170
48MP0005397_hematopoietic_system_phenotyp1.62608922
49MP0001545_abnormal_hematopoietic_system1.62608922
50MP0002084_abnormal_developmental_patter1.60189824
51MP0005380_embryogenesis_phenotype1.59764458
52MP0001672_abnormal_embryogenesis/_devel1.59764458
53MP0004947_skin_inflammation1.59496011
54MP0001293_anophthalmia1.59153164
55MP0001958_emphysema1.57991826
56MP0004133_heterotaxia1.55896257
57MP0002085_abnormal_embryonic_tissue1.55524716
58MP0003453_abnormal_keratinocyte_physiol1.53951502
59MP0003123_paternal_imprinting1.49005328
60MP0001835_abnormal_antigen_presentation1.48173401
61MP0001790_abnormal_immune_system1.48083084
62MP0005387_immune_system_phenotype1.48083084
63MP0005000_abnormal_immune_tolerance1.46842527
64MP0005023_abnormal_wound_healing1.43715416
65MP0003984_embryonic_growth_retardation1.43598730
66MP0003119_abnormal_digestive_system1.43123630
67MP0003329_amyloid_beta_deposits1.42924761
68MP0003436_decreased_susceptibility_to1.41773820
69MP0002088_abnormal_embryonic_growth/wei1.41355482
70MP0008877_abnormal_DNA_methylation1.38603336
71MP0009053_abnormal_anal_canal1.34228916
72MP0002080_prenatal_lethality1.33285128
73MP0005164_abnormal_response_to1.31720831
74MP0000490_abnormal_crypts_of1.30070121
75MP0004858_abnormal_nervous_system1.29978348
76MP0002452_abnormal_antigen_presenting1.28517813
77MP0000767_abnormal_smooth_muscle1.23347937
78MP0008058_abnormal_DNA_repair1.22356053
79MP0008007_abnormal_cellular_replicative1.21622069
80MP0002723_abnormal_immune_serum1.21140334
81MP0002282_abnormal_trachea_morphology1.16334332
82MP0005058_abnormal_lysosome_morphology1.15939939
83MP0002269_muscular_atrophy1.14895940
84MP0008469_abnormal_protein_level1.13556094
85MP0001542_abnormal_bone_strength1.13088308
86MP0003448_altered_tumor_morphology1.12519846
87MP0001819_abnormal_immune_cell1.11006110
88MP0002420_abnormal_adaptive_immunity1.11002741
89MP0002896_abnormal_bone_mineralization1.10825373
90MP0001845_abnormal_inflammatory_respons1.09414456
91MP0003828_pulmonary_edema1.09141302
92MP0002933_joint_inflammation1.08006224
93MP0009333_abnormal_splenocyte_physiolog1.07736381
94MP0002060_abnormal_skin_morphology1.07175187
95MP0005390_skeleton_phenotype1.07050564
96MP0000733_abnormal_muscle_development1.06842626
97MP0003183_abnormal_peptide_metabolism1.06716854
98MP0001853_heart_inflammation1.06694345
99MP0003283_abnormal_digestive_organ1.06636686
100MP0003786_premature_aging1.05637787
101MP0003172_abnormal_lysosome_physiology1.05135295
102MP0003950_abnormal_plasma_membrane1.04364326
103MP0002019_abnormal_tumor_incidence1.03849483
104MP0009764_decreased_sensitivity_to1.02822571
105MP0000371_diluted_coat_color1.02723534
106MP0002405_respiratory_system_inflammati1.02495794
107MP0002111_abnormal_tail_morphology1.01893933
108MP0000313_abnormal_cell_death1.01603253
109MP0010155_abnormal_intestine_physiology1.00571578
110MP0004883_abnormal_blood_vessel0.99528280
111MP0005360_urolithiasis0.98052306
112MP0010630_abnormal_cardiac_muscle0.97117647
113MP0001800_abnormal_humoral_immune0.96538788
114MP0003221_abnormal_cardiomyocyte_apopto0.95911194
115MP0003795_abnormal_bone_structure0.94872239
116MP0005166_decreased_susceptibility_to0.94046612
117MP0000750_abnormal_muscle_regeneration0.91279082
118MP0003806_abnormal_nucleotide_metabolis0.90484478
119MP0001849_ear_inflammation0.90181869
120MP0005165_increased_susceptibility_to0.89404153
121MP0010234_abnormal_vibrissa_follicle0.88661877
122MP0002089_abnormal_postnatal_growth/wei0.88111482
123MP0000685_abnormal_immune_system0.87316125
124MP0004185_abnormal_adipocyte_glucose0.85630594
125MP0002925_abnormal_cardiovascular_devel0.84686560
126MP0005671_abnormal_response_to0.84550089
127MP0002106_abnormal_muscle_physiology0.84328511
128MP0005174_abnormal_tail_pigmentation0.84006490
129MP0002332_abnormal_exercise_endurance0.83618134
130MP0008438_abnormal_cutaneous_collagen0.82966224
131MP0000249_abnormal_blood_vessel0.82294001
132MP0006072_abnormal_retinal_apoptosis0.81969531
133MP0005623_abnormal_meninges_morphology0.81466946
134MP0000003_abnormal_adipose_tissue0.80261492
135MP0000858_altered_metastatic_potential0.79345553
136MP0004808_abnormal_hematopoietic_stem0.79020912
137MP0005409_darkened_coat_color0.78948982
138MP0001915_intracranial_hemorrhage0.78921219
139MP0003656_abnormal_erythrocyte_physiolo0.78680081
140MP0000759_abnormal_skeletal_muscle0.78488567
141MP0004087_abnormal_muscle_fiber0.77944371
142MP0002697_abnormal_eye_size0.76803482
143MP0000343_altered_response_to0.76178171
144MP0000432_abnormal_head_morphology0.75091135
145MP0000716_abnormal_immune_system0.74409245
146MP0002249_abnormal_larynx_morphology0.74382846
147MP0000689_abnormal_spleen_morphology0.74245849
148MP0002396_abnormal_hematopoietic_system0.74190352
149MP0001243_abnormal_dermal_layer0.73606162
150MP0000751_myopathy0.72181373
151MP0001216_abnormal_epidermal_layer0.72171801
152MP0000747_muscle_weakness0.72165482
153MP0001348_abnormal_lacrimal_gland0.71384665
154MP0008770_decreased_survivor_rate0.70655461
155MP0004264_abnormal_extraembryonic_tissu0.70429901
156MP0005083_abnormal_biliary_tract0.70313703
157MP0000266_abnormal_heart_morphology0.70187037
158MP0002139_abnormal_hepatobiliary_system0.70164575
159MP0002722_abnormal_immune_system0.69887516
160MP0003941_abnormal_skin_development0.68523802
161MP0002932_abnormal_joint_morphology0.68423353
162MP0005501_abnormal_skin_physiology0.68206294
163MP0002092_abnormal_eye_morphology0.67645004
164MP0006082_CNS_inflammation0.67463985
165MP0005595_abnormal_vascular_smooth0.66713502
166MP0000762_abnormal_tongue_morphology0.64350742
167MP0000703_abnormal_thymus_morphology0.64002672
168MP0005508_abnormal_skeleton_morphology0.63457470
169MP0002796_impaired_skin_barrier0.63300792
170MP0002398_abnormal_bone_marrow0.62848502
171MP0003935_abnormal_craniofacial_develop0.62388545
172MP0003385_abnormal_body_wall0.62057391

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.36094784
2Abnormality of glycolipid metabolism (HP:0010969)4.24504388
3Abnormality of liposaccharide metabolism (HP:0010968)4.24504388
4Abnormality of glycosphingolipid metabolism (HP:0004343)4.24504388
5Rib fusion (HP:0000902)3.70365230
6Abnormality of macrophages (HP:0004311)3.60812705
7Exercise-induced muscle cramps (HP:0003710)3.53393415
8Vertebral compression fractures (HP:0002953)3.34637272
9Ulnar bowing (HP:0003031)3.31435517
10Selective tooth agenesis (HP:0001592)3.27548061
11Aplasia/hypoplasia of the humerus (HP:0006507)3.26011742
12Pustule (HP:0200039)3.25636966
13Rectal fistula (HP:0100590)3.25382980
14Rectovaginal fistula (HP:0000143)3.25382980
15Short humerus (HP:0005792)3.23749811
16Dysostosis multiplex (HP:0000943)3.22919394
17Facial hemangioma (HP:0000329)3.14427520
18Increased cerebral lipofuscin (HP:0011813)3.08147656
19Cerebral aneurysm (HP:0004944)3.00438342
20Intestinal fistula (HP:0100819)2.98694830
21Concave nail (HP:0001598)2.96454882
22Annular pancreas (HP:0001734)2.93603965
23Vaginal fistula (HP:0004320)2.92083798
24Vacuolated lymphocytes (HP:0001922)2.90465118
25Atrophic scars (HP:0001075)2.89186491
26Deep venous thrombosis (HP:0002625)2.82878141
27Abnormality of polysaccharide metabolism (HP:0011012)2.78047701
28Abnormality of glycosaminoglycan metabolism (HP:0004371)2.78047701
29Abnormality of mucopolysaccharide metabolism (HP:0011020)2.78047701
30Absent radius (HP:0003974)2.76834969
31Recurrent bacterial skin infections (HP:0005406)2.69367399
32Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.68935945
33Ulnar deviation of the wrist (HP:0003049)2.68752910
34Peritonitis (HP:0002586)2.67202111
35Vertebral hypoplasia (HP:0008417)2.65239880
36Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.65239880
37Myocardial infarction (HP:0001658)2.63591058
38Poikiloderma (HP:0001029)2.62845126
39Axonal loss (HP:0003447)2.61276681
40Basal cell carcinoma (HP:0002671)2.60839069
41Achilles tendon contracture (HP:0001771)2.60782252
42Loss of speech (HP:0002371)2.55844804
43Absent forearm bone (HP:0003953)2.55222435
44Aplasia involving forearm bones (HP:0009822)2.55222435
45Abnormality of the calcaneus (HP:0008364)2.54839987
46Ependymoma (HP:0002888)2.52347770
47Increased neuronal autofluorescent lipopigment (HP:0002074)2.52090724
48Amyloidosis (HP:0011034)2.49938440
49Recurrent gram-negative bacterial infections (HP:0005420)2.49261220
50Congenital hip dislocation (HP:0001374)2.46156201
51Systemic lupus erythematosus (HP:0002725)2.44857203
52Alopecia of scalp (HP:0002293)2.42239763
53Distal lower limb amyotrophy (HP:0008944)2.41586531
54Abnormality of the Achilles tendon (HP:0005109)2.41177381
55Fragile skin (HP:0001030)2.38927478
56Neurofibrillary tangles (HP:0002185)2.38233645
57Arterial tortuosity (HP:0005116)2.38027895
58Absent thumb (HP:0009777)2.37082109
59Calcaneovalgus deformity (HP:0001848)2.36229152
60Upper motor neuron abnormality (HP:0002127)2.36060362
61Spondylolisthesis (HP:0003302)2.35026028
62Cervical subluxation (HP:0003308)2.32213323
63Abnormality of the astrocytes (HP:0100707)2.30301271
64Astrocytoma (HP:0009592)2.30301271
65Distal lower limb muscle weakness (HP:0009053)2.29426687
66Vascular tortuosity (HP:0004948)2.28876936
67Nuclear cataract (HP:0100018)2.28755763
68Tongue fasciculations (HP:0001308)2.28286459
69Hemorrhage of the eye (HP:0011885)2.27615445
70Myoglobinuria (HP:0002913)2.27203894
71Abnormal number of incisors (HP:0011064)2.26009828
72Broad face (HP:0000283)2.24349187
73Orthostatic hypotension (HP:0001278)2.24329371
74Myositis (HP:0100614)2.24301608
75Aortic dissection (HP:0002647)2.24038965
76Turricephaly (HP:0000262)2.23160196
77Short nail (HP:0001799)2.23051528
78Muscle fibrillation (HP:0010546)2.22305591
79Round ear (HP:0100830)2.22255208
80Squamous cell carcinoma (HP:0002860)2.21203452
81Orchitis (HP:0100796)2.20302826
82Abnormality of abdominal situs (HP:0011620)2.18899852
83Abdominal situs inversus (HP:0003363)2.18899852
84Blue sclerae (HP:0000592)2.18271890
85Patellar aplasia (HP:0006443)2.16893377
86Rhabdomyolysis (HP:0003201)2.15710668
87Exercise-induced myalgia (HP:0003738)2.14747545
88Muscle fiber inclusion bodies (HP:0100299)2.14089921
89Deformed tarsal bones (HP:0008119)2.14078284
90Metaphyseal cupping (HP:0003021)2.13996510
91Thin bony cortex (HP:0002753)2.13702381
92Increased IgM level (HP:0003496)2.12422760
93Eczematoid dermatitis (HP:0000976)2.10342021
94Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.09652228
95Vertebral fusion (HP:0002948)2.09198950
96Hyperacusis (HP:0010780)2.08740663
97Cellulitis (HP:0100658)2.08661982
98Purpura (HP:0000979)2.08181048
99Abnormality of the aortic arch (HP:0012303)2.06884256
100Elbow flexion contracture (HP:0002987)2.06349518
101Agnosia (HP:0010524)2.06193949
102Ankle contracture (HP:0006466)2.05550993
103Cerebral inclusion bodies (HP:0100314)2.05520707
104Aplasia/Hypoplasia of the patella (HP:0006498)2.04934763
105Flat acetabular roof (HP:0003180)2.04852785
106Increased serum ferritin (HP:0003281)2.04176788
107Albinism (HP:0001022)2.02236337
108Wormian bones (HP:0002645)2.01598262
109Trismus (HP:0000211)2.01406828
110Dilatation of the ascending aorta (HP:0005111)2.01395654
111Pathologic fracture (HP:0002756)2.00297637
112Gingivitis (HP:0000230)1.99289514
113Increased density of long bones (HP:0006392)1.97383200
114Distal upper limb amyotrophy (HP:0007149)1.95588050
115Upper limb amyotrophy (HP:0009129)1.95588050
116Asymmetric septal hypertrophy (HP:0001670)1.95447794
117Osteolytic defects of the phalanges of the hand (HP:0009771)1.95340516
118Osteolytic defects of the hand bones (HP:0009699)1.95340516
119Premature graying of hair (HP:0002216)1.94560323
120Male infertility (HP:0003251)1.94218683
121Myopathic facies (HP:0002058)1.92334885
122Abnormal hemoglobin (HP:0011902)1.91715730
123Coronal craniosynostosis (HP:0004440)1.90781512
124Natal tooth (HP:0000695)1.90290488
125Missing ribs (HP:0000921)1.89952568
126Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.89624415
127Aneurysm (HP:0002617)1.88012560
128Nemaline bodies (HP:0003798)1.84216986
129Mitral stenosis (HP:0001718)1.84196900
130Bone pain (HP:0002653)1.83935473
131Spinal rigidity (HP:0003306)1.83794110
132Glomerulonephritis (HP:0000099)1.83741251
133Disproportionate tall stature (HP:0001519)1.82994160
134Abnormality of complement system (HP:0005339)1.82474728
135Xanthomatosis (HP:0000991)1.81855922
136Increased connective tissue (HP:0009025)1.81561891
137Aortic aneurysm (HP:0004942)1.81413464
138Abnormal ossification of hand bones (HP:0005921)1.81065094
139Malnutrition (HP:0004395)1.80287524
140Bowing of the arm (HP:0006488)1.80095563
141Bowed forearm bones (HP:0003956)1.80095563
142Abnormality of the labia minora (HP:0012880)1.78586112
143Abnormality of carpal bone ossification (HP:0006257)1.76974351
144Mitral regurgitation (HP:0001653)1.76572438
145Chronic obstructive pulmonary disease (HP:0006510)1.75206286
146Obstructive lung disease (HP:0006536)1.75206286
147Type 1 muscle fiber predominance (HP:0003803)1.74684213
148Broad thumb (HP:0011304)1.74557662
149Protrusio acetabuli (HP:0003179)1.73900653
150Bladder diverticulum (HP:0000015)1.73810903
151Intestinal atresia (HP:0011100)1.73629958
152Distal arthrogryposis (HP:0005684)1.72874845
153Muscle stiffness (HP:0003552)1.72213668
154Recurrent abscess formation (HP:0002722)1.72185123
155Interstitial pulmonary disease (HP:0006530)1.71738488
156Genu recurvatum (HP:0002816)1.70925896
157Cheilitis (HP:0100825)1.70910384
158Joint stiffness (HP:0001387)1.70604424
159Broad alveolar ridges (HP:0000187)1.70390229
160Abnormality of the acetabulum (HP:0003170)1.70146720
161Generalized amyotrophy (HP:0003700)1.69260584
162Coxa vara (HP:0002812)1.68821071
163Polycythemia (HP:0001901)1.67616122
164Difficulty climbing stairs (HP:0003551)1.67411727
165Mediastinal lymphadenopathy (HP:0100721)1.66492546
166Hepatosplenomegaly (HP:0001433)1.65929065
167Segmental peripheral demyelination/remyelination (HP:0003481)1.65728361
168Biconcave vertebral bodies (HP:0004586)1.64731187
169Hypotelorism (HP:0000601)1.64271662
170Ovoid vertebral bodies (HP:0003300)1.64016306
171Hypertriglyceridemia (HP:0002155)1.63715872
172Fused cervical vertebrae (HP:0002949)1.63573402
173Diaphragmatic weakness (HP:0009113)1.63229261
174Choanal stenosis (HP:0000452)1.63177161
175Short 5th finger (HP:0009237)1.62388734
176Rhabdomyosarcoma (HP:0002859)1.61601071
177Urinary glycosaminoglycan excretion (HP:0003541)1.61057856
178Mucopolysacchariduria (HP:0008155)1.61057856
179Deviation of the thumb (HP:0009603)1.60478764
180Breast hypoplasia (HP:0003187)1.60342819
181Abnormality of the anterior horn cell (HP:0006802)1.60060970
182Degeneration of anterior horn cells (HP:0002398)1.60060970
183Neoplasm of the oral cavity (HP:0100649)1.59932316
184Hypochromic anemia (HP:0001931)1.59445808
185Reticulocytopenia (HP:0001896)1.59082840
186Spinal muscular atrophy (HP:0007269)1.58907305

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK3.97116774
2IRAK33.19557649
3DDR23.13568105
4MAP3K113.01337097
5PKN22.78498203
6FGR2.37842729
7BMX2.30370821
8SIK12.25469692
9TGFBR22.24718812
10PRPF4B2.15773083
11MAP3K62.11464251
12MST1R2.05601151
13CDK122.03791098
14MAP3K101.96673412
15TRIB31.96098291
16CDK71.95660702
17CDC71.88862807
18CSK1.83822123
19NEK21.80748270
20SMG11.80258628
21BUB11.80258158
22MATK1.77803139
23TYRO31.64701427
24WEE11.63591886
25STK101.63571998
26EPHB11.62643142
27PIM21.59554976
28NEK11.59226075
29FLT31.58377946
30PDGFRA1.56996493
31EEF2K1.55332658
32MAP3K131.51425054
33MAPK151.49355363
34MAP3K141.47734572
35TTN1.47673490
36IRAK41.46257829
37CDK61.44608476
38PAK41.43920212
39ZAP701.43496488
40PIM11.39775045
41TBK11.36060297
42RIPK41.32833448
43DYRK1B1.32579022
44MOS1.30611981
45FGFR41.28570385
46TESK21.27590759
47ALK1.27309453
48ARAF1.24105037
49MAP3K81.20515993
50MAP2K31.19619364
51RPS6KB21.17944110
52TLK11.16991515
53LATS21.16763286
54YES11.14855721
55PLK11.14078405
56TRPM71.11139799
57EPHB21.11003338
58EPHA21.07667713
59UHMK11.06334703
60PRKD21.06127210
61MAP3K11.05584400
62BLK1.05157803
63RPS6KL11.04878966
64RPS6KC11.04878966
65LIMK11.03603244
66PDPK11.00869111
67NEK90.98694384
68MTOR0.97767620
69DAPK10.94653699
70JAK30.94308836
71FGFR10.93874359
72TTK0.93266767
73CSF1R0.90310606
74ABL20.90307109
75RPS6KA60.89494092
76PTK20.88435459
77CDK40.88146306
78ATR0.87187584
79KSR20.87030288
80RPS6KA20.86125666
81EIF2AK10.85262485
82PRKG20.85181126
83CHEK20.82079117
84PHKG10.81615470
85PHKG20.81615470
86SIK20.79058618
87LRRK20.78660474
88RIPK10.74759169
89MAPK110.74618867
90STK380.72923647
91TAOK20.72917202
92NTRK10.72802604
93DMPK0.71361634
94RPS6KA10.70680978
95GRK70.70200294
96AURKB0.69790081
97STK40.69404931
98PINK10.69316159
99AURKA0.68079411
100SCYL20.68021188
101GSK3A0.67525008
102MARK20.67342410
103CHEK10.66820108
104ERN10.65109432
105OBSCN0.64668633
106CDK20.64445160
107PTK60.62700287
108PAK10.62490988
109MAP4K10.61182632
110NME20.60219625
111DYRK30.59229759
112RPS6KA40.58613118
113STK30.58488503
114SIK30.57617829
115MAPKAPK30.57600308
116PDGFRB0.56396176
117PLK40.56302988
118JAK10.55998126
119PDK10.54384889
120HCK0.53908430
121EGFR0.52400704
122CDC42BPA0.51110879
123LMTK20.50541847
124TESK10.50431995
125ATM0.50403613
126AKT20.49598596
127MAP3K30.49133468
128IKBKB0.48741819
129MET0.46052678
130PAK20.45536743
131MAPKAPK20.43804199
132PDK20.43217879
133GRK60.42201521
134TYK20.41908033
135CSNK2A10.41726744
136BRAF0.41599847
137MAPK120.39817072
138TAOK10.39729594
139IRAK20.39498551
140MAP3K90.38179615
141LYN0.36798680
142ERBB40.36711710
143MAP2K60.36530199
144CLK10.36353726
145CSNK2A20.35960620
146MAPK10.35043393
147MAP3K70.33341857
148HIPK20.30910835
149LCK0.30582946

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.76851758
2DNA replication_Homo sapiens_hsa030303.65284016
3Other glycan degradation_Homo sapiens_hsa005113.63190355
4Base excision repair_Homo sapiens_hsa034103.18072650
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.77170286
6Spliceosome_Homo sapiens_hsa030402.36656566
7RNA transport_Homo sapiens_hsa030132.36514416
8Lysosome_Homo sapiens_hsa041422.36509358
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.27560232
10One carbon pool by folate_Homo sapiens_hsa006702.05936048
11Cell cycle_Homo sapiens_hsa041101.89909681
12Nucleotide excision repair_Homo sapiens_hsa034201.87053027
13Staphylococcus aureus infection_Homo sapiens_hsa051501.85100989
14Biosynthesis of amino acids_Homo sapiens_hsa012301.80863667
15mRNA surveillance pathway_Homo sapiens_hsa030151.80321251
16Homologous recombination_Homo sapiens_hsa034401.75759173
17Fatty acid biosynthesis_Homo sapiens_hsa000611.75529786
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.68378568
19Ribosome_Homo sapiens_hsa030101.67071559
20TNF signaling pathway_Homo sapiens_hsa046681.56657809
21p53 signaling pathway_Homo sapiens_hsa041151.55190386
22Bladder cancer_Homo sapiens_hsa052191.54502492
23mTOR signaling pathway_Homo sapiens_hsa041501.50471478
24Adherens junction_Homo sapiens_hsa045201.47617883
25Notch signaling pathway_Homo sapiens_hsa043301.44678833
26HIF-1 signaling pathway_Homo sapiens_hsa040661.44343571
27Phagosome_Homo sapiens_hsa041451.43972200
28Pertussis_Homo sapiens_hsa051331.43810931
29Amoebiasis_Homo sapiens_hsa051461.43160233
30Fructose and mannose metabolism_Homo sapiens_hsa000511.42903523
31Hippo signaling pathway_Homo sapiens_hsa043901.40906838
32Legionellosis_Homo sapiens_hsa051341.40223163
33* Central carbon metabolism in cancer_Homo sapiens_hsa052301.35114097
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.34736589
35Shigellosis_Homo sapiens_hsa051311.34688582
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.33644230
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.31986028
38Complement and coagulation cascades_Homo sapiens_hsa046101.31332147
39MicroRNAs in cancer_Homo sapiens_hsa052061.29630294
40Fanconi anemia pathway_Homo sapiens_hsa034601.29063709
41Galactose metabolism_Homo sapiens_hsa000521.27999181
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.26823282
43Prion diseases_Homo sapiens_hsa050201.26417664
44Viral carcinogenesis_Homo sapiens_hsa052031.22024076
45Chronic myeloid leukemia_Homo sapiens_hsa052201.16220651
46Viral myocarditis_Homo sapiens_hsa054161.16144809
47TGF-beta signaling pathway_Homo sapiens_hsa043501.16057800
48Hedgehog signaling pathway_Homo sapiens_hsa043401.09655125
49NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08435982
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07557391
51Rheumatoid arthritis_Homo sapiens_hsa053231.06792753
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.06100689
53Leishmaniasis_Homo sapiens_hsa051401.03940255
54Basal cell carcinoma_Homo sapiens_hsa052171.03389279
55Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03096599
56Influenza A_Homo sapiens_hsa051641.02697734
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00218428
58Small cell lung cancer_Homo sapiens_hsa052220.99946806
59ECM-receptor interaction_Homo sapiens_hsa045120.99446007
60Pentose phosphate pathway_Homo sapiens_hsa000300.99038522
61Epstein-Barr virus infection_Homo sapiens_hsa051690.98408961
62Herpes simplex infection_Homo sapiens_hsa051680.96735821
63VEGF signaling pathway_Homo sapiens_hsa043700.96171141
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95605360
65Acute myeloid leukemia_Homo sapiens_hsa052210.95118382
66Endocytosis_Homo sapiens_hsa041440.93919658
67Hepatitis C_Homo sapiens_hsa051600.93913038
68Hematopoietic cell lineage_Homo sapiens_hsa046400.93673743
69RNA degradation_Homo sapiens_hsa030180.93526730
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90702802
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90649965
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.90250782
73Thyroid cancer_Homo sapiens_hsa052160.89443696
74HTLV-I infection_Homo sapiens_hsa051660.89355642
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89228085
76Proteoglycans in cancer_Homo sapiens_hsa052050.88225908
77Chemokine signaling pathway_Homo sapiens_hsa040620.86876407
78RNA polymerase_Homo sapiens_hsa030200.86228748
79Systemic lupus erythematosus_Homo sapiens_hsa053220.85297717
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85103504
81Vibrio cholerae infection_Homo sapiens_hsa051100.82740744
82Colorectal cancer_Homo sapiens_hsa052100.81183872
83Proteasome_Homo sapiens_hsa030500.80231187
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80072731
85Apoptosis_Homo sapiens_hsa042100.78608723
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78133336
87African trypanosomiasis_Homo sapiens_hsa051430.77991137
88Arginine and proline metabolism_Homo sapiens_hsa003300.77577884
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.77523821
90Oocyte meiosis_Homo sapiens_hsa041140.77045101
91Sulfur relay system_Homo sapiens_hsa041220.76032734
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75010874
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73025978
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72901700
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.72822940
96Hepatitis B_Homo sapiens_hsa051610.72696766
97Tight junction_Homo sapiens_hsa045300.72673856
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70249942
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.68180470
100Pyrimidine metabolism_Homo sapiens_hsa002400.67944362
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67302489
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66872918
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66026743
104Graft-versus-host disease_Homo sapiens_hsa053320.65360962
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.63785936
106Allograft rejection_Homo sapiens_hsa053300.62468529
107Platelet activation_Homo sapiens_hsa046110.62261283
108GnRH signaling pathway_Homo sapiens_hsa049120.61499981
109Focal adhesion_Homo sapiens_hsa045100.61018401
110Lysine degradation_Homo sapiens_hsa003100.60891848
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60805360
112Measles_Homo sapiens_hsa051620.60607330
113Salmonella infection_Homo sapiens_hsa051320.60200561
114Carbon metabolism_Homo sapiens_hsa012000.59109262
115Antigen processing and presentation_Homo sapiens_hsa046120.57598062
116Wnt signaling pathway_Homo sapiens_hsa043100.57451638
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57309168
118Insulin signaling pathway_Homo sapiens_hsa049100.57183082
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.56925361
120Jak-STAT signaling pathway_Homo sapiens_hsa046300.56800756
121Insulin resistance_Homo sapiens_hsa049310.56502134
122Pathways in cancer_Homo sapiens_hsa052000.55815931
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54938169
124Prolactin signaling pathway_Homo sapiens_hsa049170.54248765
125Pancreatic cancer_Homo sapiens_hsa052120.53696448
126Sphingolipid metabolism_Homo sapiens_hsa006000.53331250
127T cell receptor signaling pathway_Homo sapiens_hsa046600.52435009
128Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51812653
1292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50897000
130AMPK signaling pathway_Homo sapiens_hsa041520.50545007
131Osteoclast differentiation_Homo sapiens_hsa043800.49358135
132B cell receptor signaling pathway_Homo sapiens_hsa046620.49355674
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48409697
134Renal cell carcinoma_Homo sapiens_hsa052110.48385996
135Mineral absorption_Homo sapiens_hsa049780.46144651
136Autoimmune thyroid disease_Homo sapiens_hsa053200.45281345
137N-Glycan biosynthesis_Homo sapiens_hsa005100.45058006
138Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45040490
139Melanoma_Homo sapiens_hsa052180.42250657
140Toxoplasmosis_Homo sapiens_hsa051450.40393904
141Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40152389
142Endometrial cancer_Homo sapiens_hsa052130.38654173
143Tuberculosis_Homo sapiens_hsa051520.38271244
144Non-small cell lung cancer_Homo sapiens_hsa052230.38215672
145Neurotrophin signaling pathway_Homo sapiens_hsa047220.37391197
146Basal transcription factors_Homo sapiens_hsa030220.37384570
147Malaria_Homo sapiens_hsa051440.36976328
148Prostate cancer_Homo sapiens_hsa052150.36178620
149PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35921281

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »