SLC16A5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the monocarboxylate transporter family and the major facilitator superfamily. The encoded protein is localized to the cell membrane and acts as a proton-linked transporter of bumetanide. Transport by the encoded protein is inhibited by four loop diuretics, nateglinide, thiazides, probenecid, and glibenclamide. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.84257967
2L-phenylalanine catabolic process (GO:0006559)6.83665580
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.83665580
4L-phenylalanine metabolic process (GO:0006558)6.61427521
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.61427521
6intestinal cholesterol absorption (GO:0030299)6.02247486
7aromatic amino acid family catabolic process (GO:0009074)5.94499061
8high-density lipoprotein particle remodeling (GO:0034375)5.61259026
9regulation of cholesterol esterification (GO:0010872)5.45472574
10cysteine metabolic process (GO:0006534)5.38405784
11urea cycle (GO:0000050)5.36935824
12urea metabolic process (GO:0019627)5.36935824
13alpha-linolenic acid metabolic process (GO:0036109)5.32313758
14neutrophil activation involved in immune response (GO:0002283)5.29516668
15drug catabolic process (GO:0042737)5.24511424
16phospholipid efflux (GO:0033700)5.17857789
17negative regulation of cholesterol transport (GO:0032375)5.17559396
18negative regulation of sterol transport (GO:0032372)5.17559396
19indole-containing compound catabolic process (GO:0042436)5.15258602
20indolalkylamine catabolic process (GO:0046218)5.15258602
21tryptophan catabolic process (GO:0006569)5.15258602
22sulfur amino acid catabolic process (GO:0000098)5.13168606
23kynurenine metabolic process (GO:0070189)5.09423707
24regulation of triglyceride catabolic process (GO:0010896)5.08036790
25reverse cholesterol transport (GO:0043691)4.97824989
26homocysteine metabolic process (GO:0050667)4.96373198
27nitrogen cycle metabolic process (GO:0071941)4.91007186
28glyoxylate metabolic process (GO:0046487)4.89721927
29tryptophan metabolic process (GO:0006568)4.89584376
30serine family amino acid catabolic process (GO:0009071)4.87662273
31bile acid biosynthetic process (GO:0006699)4.87267032
32protein-lipid complex remodeling (GO:0034368)4.77863713
33macromolecular complex remodeling (GO:0034367)4.77863713
34plasma lipoprotein particle remodeling (GO:0034369)4.77863713
35intestinal absorption (GO:0050892)4.76606029
36modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.65384969
37positive regulation by organism of defense response of other organism involved in symbiotic interact4.65384969
38modulation by symbiont of host immune response (GO:0052553)4.65384969
39positive regulation by symbiont of host defense response (GO:0052509)4.65384969
40modulation by symbiont of host defense response (GO:0052031)4.65384969
41modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.65384969
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.64508602
43negative regulation of fibrinolysis (GO:0051918)4.63197771
44bile acid metabolic process (GO:0008206)4.60769167
45amino-acid betaine metabolic process (GO:0006577)4.60139623
46response to peptidoglycan (GO:0032494)4.59895249
47fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.55750643
48lysine metabolic process (GO:0006553)4.51736300
49lysine catabolic process (GO:0006554)4.51736300
50plasma lipoprotein particle assembly (GO:0034377)4.51600194
51flavonoid metabolic process (GO:0009812)4.48660142
52cholesterol efflux (GO:0033344)4.45730963
53antigen processing and presentation of endogenous antigen (GO:0019883)4.43781408
54triglyceride homeostasis (GO:0070328)4.43656395
55acylglycerol homeostasis (GO:0055090)4.43656395
56bile acid and bile salt transport (GO:0015721)4.42076840
57positive regulation of triglyceride lipase activity (GO:0061365)4.40312062
58positive regulation of lipoprotein lipase activity (GO:0051006)4.40312062
59peptidyl-glutamic acid carboxylation (GO:0017187)4.39169899
60protein carboxylation (GO:0018214)4.39169899
61detection of other organism (GO:0098543)4.38837410
62aromatic amino acid family metabolic process (GO:0009072)4.37336080
63cellular ketone body metabolic process (GO:0046950)4.32342546
64regulation of fibrinolysis (GO:0051917)4.31179268
65regulation of bile acid biosynthetic process (GO:0070857)4.30336060
66detection of bacterium (GO:0016045)4.27475100
67cellular extravasation (GO:0045123)4.26332442
68alpha-amino acid catabolic process (GO:1901606)4.22524216
69negative regulation of cell killing (GO:0031342)4.19406799
70negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.19406799
71glycine metabolic process (GO:0006544)4.16236092
72tyrosine metabolic process (GO:0006570)4.13175002
73positive regulation of gamma-delta T cell activation (GO:0046645)4.12694506
74plasma lipoprotein particle clearance (GO:0034381)4.11807502
75cholesterol homeostasis (GO:0042632)4.09950707
76cellular glucuronidation (GO:0052695)4.08930089
77serine family amino acid biosynthetic process (GO:0009070)4.08029829
78drug metabolic process (GO:0017144)4.07539374
79protein-lipid complex assembly (GO:0065005)4.07323440
80antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.05538300
81serine family amino acid metabolic process (GO:0009069)4.04647518
82sterol homeostasis (GO:0055092)4.04191906
83regulation of cholesterol homeostasis (GO:2000188)4.03863218
84exogenous drug catabolic process (GO:0042738)4.02806606
85very-low-density lipoprotein particle assembly (GO:0034379)3.98691274
86cellular amino acid catabolic process (GO:0009063)3.95904267
87cellular modified amino acid catabolic process (GO:0042219)3.92058852
88glutamate metabolic process (GO:0006536)3.90331039
89regulation of protein activation cascade (GO:2000257)3.85283544
90positive regulation of lipid catabolic process (GO:0050996)3.81742463
91lipoprotein metabolic process (GO:0042157)3.81677141
92complement activation, alternative pathway (GO:0006957)3.79058561
93phospholipid homeostasis (GO:0055091)3.78731839
94macrophage activation involved in immune response (GO:0002281)3.76431156
95neutrophil activation (GO:0042119)3.74735977
96plasma lipoprotein particle organization (GO:0071827)3.74419732
97short-chain fatty acid metabolic process (GO:0046459)3.72953205
98ketone body metabolic process (GO:1902224)3.71591302
99benzene-containing compound metabolic process (GO:0042537)3.71471285
100arginine metabolic process (GO:0006525)3.70952415
101positive regulation of Cdc42 GTPase activity (GO:0043089)3.67384076
102axonemal dynein complex assembly (GO:0070286)3.65427400
103regulation of T-helper 2 cell differentiation (GO:0045628)3.65018724
104coenzyme catabolic process (GO:0009109)3.63098748
105indolalkylamine metabolic process (GO:0006586)3.62772577
106regulation of myeloid leukocyte mediated immunity (GO:0002886)3.62722892
107low-density lipoprotein particle remodeling (GO:0034374)3.60996539
108uronic acid metabolic process (GO:0006063)3.60801830
109glucuronate metabolic process (GO:0019585)3.60801830
110regulation of leukocyte degranulation (GO:0043300)3.60391613
111negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.60155746
112drug transmembrane transport (GO:0006855)3.60014084
113regulation of mast cell degranulation (GO:0043304)3.58020445
114antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.57474533
115organic acid catabolic process (GO:0016054)3.55786362
116carboxylic acid catabolic process (GO:0046395)3.55786362
117detection of external biotic stimulus (GO:0098581)3.55386097
118ethanol oxidation (GO:0006069)3.54610663
119protein-lipid complex subunit organization (GO:0071825)3.53690034
120negative regulation of lipase activity (GO:0060192)3.50071579
121regulation of complement activation (GO:0030449)3.49667124
122immunoglobulin mediated immune response (GO:0016064)3.49210704
123cellular biogenic amine catabolic process (GO:0042402)3.46955782
124amine catabolic process (GO:0009310)3.46955782
125carnitine metabolic process (GO:0009437)3.46673155
126respiratory burst (GO:0045730)3.46386260
127imidazole-containing compound metabolic process (GO:0052803)3.42734948
1282-oxoglutarate metabolic process (GO:0006103)3.41659620
129response to host (GO:0075136)3.41049373
130response to host defenses (GO:0052200)3.41049373
131response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.41049373
132cholesterol transport (GO:0030301)3.39641794
133sterol transport (GO:0015918)3.39641794
134granulocyte activation (GO:0036230)3.35787059
135response to host immune response (GO:0052572)3.34040161
136response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.34040161
137tolerance induction (GO:0002507)3.33451573
138negative regulation of lymphocyte mediated immunity (GO:0002707)3.28575505
139regulation of gamma-delta T cell activation (GO:0046643)3.24018681
140regulation of interferon-beta biosynthetic process (GO:0045357)3.23500969
141negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.22996907
142negative regulation of T-helper cell differentiation (GO:0045623)3.22996907
143regulation of mast cell activation involved in immune response (GO:0033006)3.21404336
144positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.21110537
145cilium or flagellum-dependent cell motility (GO:0001539)3.14261883
146detection of molecule of bacterial origin (GO:0032490)3.11221234
147negative regulation of erythrocyte differentiation (GO:0045647)3.09190854
148detection of biotic stimulus (GO:0009595)3.02909887
149regulation of dendritic cell antigen processing and presentation (GO:0002604)3.02886674
150negative regulation of interleukin-8 production (GO:0032717)2.97398242
151negative regulation of leukocyte mediated immunity (GO:0002704)2.96269624
152germinal center formation (GO:0002467)2.96131885
153leukocyte migration involved in inflammatory response (GO:0002523)2.94206734
154negative regulation of toll-like receptor signaling pathway (GO:0034122)2.93333424
155microglial cell activation (GO:0001774)2.92960165
156regulation of regulated secretory pathway (GO:1903305)2.92782613
157negative regulation of type 2 immune response (GO:0002829)2.91868570
158positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.91509933
159regulation of gamma-delta T cell differentiation (GO:0045586)2.90264774
160myeloid cell activation involved in immune response (GO:0002275)2.89130584
161regulation of B cell receptor signaling pathway (GO:0050855)2.87702688
162macrophage activation (GO:0042116)2.86380689
163regulation of tolerance induction (GO:0002643)2.84731632
164negative regulation of interleukin-12 production (GO:0032695)2.84461087
165pentose-phosphate shunt (GO:0006098)2.84386947
166neutrophil mediated immunity (GO:0002446)2.84012212
167B cell mediated immunity (GO:0019724)2.83784568
168leukocyte aggregation (GO:0070486)2.82966556
169negative regulation of interleukin-6 production (GO:0032715)2.82105511
170regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.81949586
171regulation of superoxide anion generation (GO:0032928)2.80910690
172positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.77883100
173positive regulation of B cell differentiation (GO:0045579)2.77868403
174response to muramyl dipeptide (GO:0032495)2.75936729
175positive regulation of mast cell activation (GO:0033005)2.75779327
176embryonic process involved in female pregnancy (GO:0060136)2.74042919
177positive regulation of tolerance induction (GO:0002645)2.71810311
178regulation of mast cell activation (GO:0033003)2.69338116
179citrulline biosynthetic process (GO:0019240)2.67633624
180antigen processing and presentation via MHC class Ib (GO:0002475)2.66221399
181primary alcohol catabolic process (GO:0034310)2.61612354
182negative regulation of phagocytosis (GO:0050765)2.61476271
183response to type I interferon (GO:0034340)2.61258629
184leukocyte degranulation (GO:0043299)2.61210579
185cellular response to type I interferon (GO:0071357)2.60645182
186type I interferon signaling pathway (GO:0060337)2.60645182
187phospholipid scrambling (GO:0017121)2.60340909
188motile cilium assembly (GO:0044458)2.58090580
189NADPH regeneration (GO:0006740)2.57149284
190positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.55529166
191pinocytosis (GO:0006907)2.54719529
192positive regulation of mast cell degranulation (GO:0043306)2.53975968
193positive regulation of mast cell activation involved in immune response (GO:0033008)2.53975968
194positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.53058121
195lipoxygenase pathway (GO:0019372)2.51963522
196negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.51410014
197positive regulation of leukocyte degranulation (GO:0043302)2.50672335
198negative regulation of T cell mediated immunity (GO:0002710)2.49992965
199desmosome organization (GO:0002934)2.49687380
200barbed-end actin filament capping (GO:0051016)2.48972108

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.81277907
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.89348296
3LXR_22158963_ChIP-Seq_LIVER_Mouse6.14778134
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.92768130
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.85299775
6* CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.65979989
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.64829657
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.66569393
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.50471117
10VDR_21846776_ChIP-Seq_THP-1_Human2.87359544
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.57380305
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.54262237
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.45311760
14VDR_24763502_ChIP-Seq_THP-1_Human2.42296185
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.19837971
16* ELK3_25401928_ChIP-Seq_HUVEC_Human2.11100872
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.04645632
18RUNX1_22412390_ChIP-Seq_EML_Mouse2.00589578
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.8313156
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98421719
21KDM2B_26808549_Chip-Seq_SUP-B15_Human1.95963249
22TCF7_22412390_ChIP-Seq_EML_Mouse1.95935988
23SPI1_23127762_ChIP-Seq_K562_Human1.94955628
24TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.92714427
25MYB_21317192_ChIP-Seq_ERMYB_Mouse1.91640669
26* SPI1_23547873_ChIP-Seq_NB4_Human1.87368574
27IRF8_27001747_Chip-Seq_BMDM_Mouse1.84730830
28CLOCK_20551151_ChIP-Seq_293T_Human1.77741433
29KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.76678309
30SOX2_27498859_Chip-Seq_STOMACH_Mouse1.74072833
31SCL_19346495_ChIP-Seq_HPC-7_Human1.68612014
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.66825663
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.63094578
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59213278
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.58757919
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54999441
37STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.54952582
38GATA4_25053715_ChIP-Seq_YYC3_Human1.52465463
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.51470014
40* FOXA2_19822575_ChIP-Seq_HepG2_Human1.50741634
41* HNF4A_19822575_ChIP-Seq_HepG2_Human1.49350750
42CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.48391628
43KDM2B_26808549_Chip-Seq_DND41_Human1.46426249
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46113254
45CDX2_20551321_ChIP-Seq_CACO-2_Human1.45371652
46GATA1_22383799_ChIP-Seq_G1ME_Mouse1.45046390
47TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40345651
48IRF8_22096565_ChIP-ChIP_GC-B_Human1.39767319
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.39698496
50PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.39186241
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37493063
52MAF_26560356_Chip-Seq_TH2_Human1.35909446
53P63_26484246_Chip-Seq_KERATINOCYTES_Human1.35133925
54CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35096233
55GATA1_22025678_ChIP-Seq_K562_Human1.34895985
56BCL6_27268052_Chip-Seq_Bcells_Human1.33701481
57GATA2_21666600_ChIP-Seq_HMVEC_Human1.31943285
58PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29876447
59P68_20966046_ChIP-Seq_HELA_Human1.29821343
60NCOR1_26117541_ChIP-Seq_K562_Human1.28962742
61MYB_26560356_Chip-Seq_TH2_Human1.27253904
62IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26716165
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24914385
64TP63_17297297_ChIP-ChIP_HaCaT_Human1.23952616
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23826557
66* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23096541
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20028191
68CTCF_27219007_Chip-Seq_ERYTHROID_Human1.19652431
69LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18457131
70SMC4_20622854_ChIP-Seq_HELA_Human1.18028971
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.16289590
72CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15536789
73* GATA6_25053715_ChIP-Seq_YYC3_Human1.15483863
74ELF1_17652178_ChIP-ChIP_JURKAT_Human1.15080486
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.14017603
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.13051510
77SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11201706
78PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09679402
79ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08941441
80STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.08519619
81NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05656184
82* ATF3_27146783_Chip-Seq_COLON_Human1.05378104
83HTT_18923047_ChIP-ChIP_STHdh_Human1.04197545
84RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02908967
85ESR1_20079471_ChIP-ChIP_T-47D_Human1.02479353
86TET1_21451524_ChIP-Seq_MESCs_Mouse1.01665608
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01595042
88* TP63_22573176_ChIP-Seq_HFKS_Human1.01245926
89SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99352951
90ESR2_21235772_ChIP-Seq_MCF-7_Human0.93126674
91* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.86938005
92STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.84790132
93LXR_22292898_ChIP-Seq_THP-1_Human0.84540106
94NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.83989385
95FOXO3_23340844_ChIP-Seq_DLD1_Human0.83973955
96ZNF263_19887448_ChIP-Seq_K562_Human0.83236646
97* RARA_24833708_ChIP-Seq_LIVER_Mouse0.83018139
98* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.78610614
99GATA2_19941826_ChIP-Seq_K562_Human0.78586333
100RACK7_27058665_Chip-Seq_MCF-7_Human0.78097274
101FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.75830442
102BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.75502280
103RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.74479843
104KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74371327
105E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.73910799
106ESR1_21235772_ChIP-Seq_MCF-7_Human0.73215400
107RUNX_20019798_ChIP-Seq_JUKART_Human0.73208395
108AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.73076128
109ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.72493667
110CEBPB_22108803_ChIP-Seq_LS180_Human0.72126385
111PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.70956076
112* RARB_24833708_ChIP-Seq_LIVER_Mouse0.70888041
113RARG_19884340_ChIP-ChIP_MEFs_Mouse0.67608616
114SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.66998305
115FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.66357449
116* SOX2_20726797_ChIP-Seq_SW620_Human0.65746723
117* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.65212712
118GATA1_19941827_ChIP-Seq_MEL_Mouse0.65073008
119GATA1_19941826_ChIP-Seq_K562_Human0.64589222
120GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.64556275
121BRD4_27068464_Chip-Seq_AML-cells_Mouse0.64137180
122UTX_26944678_Chip-Seq_JUKART_Human0.64082218
123CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.63738462
124KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.63254142
125Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.63242709
126FOXA1_25552417_ChIP-Seq_VCAP_Human0.62961989
127EGR1_19032775_ChIP-ChIP_M12_Human0.62790496
128PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.62291076
129GATA2_22383799_ChIP-Seq_G1ME_Mouse0.62267243
130KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.62248484
131STAT3_1855785_ChIP-Seq_MESCs_Mouse0.62146052
132BCOR_27268052_Chip-Seq_Bcells_Human0.61875654
133SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.61284474
134FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.60508755
135ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.60157065
136BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.59969668
137FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.59585197
138MYC_19915707_ChIP-ChIP_AK7_Human0.59219387
139MAF_26560356_Chip-Seq_TH1_Human0.58857442
140FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.58697034
141AUTS2_25519132_ChIP-Seq_293T-REX_Human0.57441357
142CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.57003077
143CREB1_26743006_Chip-Seq_LNCaP_Human0.56990170
144SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.56634268
145E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.55355744
146KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.55186246
147NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.54861544
148NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.53070745
149* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52942884
150AR_20517297_ChIP-Seq_VCAP_Human0.52240797
151FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.51957624
152* MYB_26560356_Chip-Seq_TH1_Human0.51481746
153MYC_22102868_ChIP-Seq_BL_Human0.51189129
154SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.50940669
155FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.50553835
156* RUNX1_27514584_Chip-Seq_MCF-7_Human0.50334397
157P53_21459846_ChIP-Seq_SAOS-2_Human0.50191239

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.92929811
2MP0002139_abnormal_hepatobiliary_system7.37345941
3MP0005365_abnormal_bile_salt5.97366260
4MP0005085_abnormal_gallbladder_physiolo5.80742872
5MP0008875_abnormal_xenobiotic_pharmacok5.10933445
6MP0001666_abnormal_nutrient_absorption4.02494378
7MP0009840_abnormal_foam_cell3.66867078
8MP0003252_abnormal_bile_duct3.56722764
9MP0010329_abnormal_lipoprotein_level3.38366403
10MP0003806_abnormal_nucleotide_metabolis3.35860120
11MP0005083_abnormal_biliary_tract2.98803764
12MP0001835_abnormal_antigen_presentation2.65874404
13MP0005332_abnormal_amino_acid2.65414608
14MP0003303_peritoneal_inflammation2.60331208
15MP0002419_abnormal_innate_immunity2.55022688
16MP0009278_abnormal_bone_marrow2.41894609
17MP0004019_abnormal_vitamin_homeostasis2.30050426
18MP0003191_abnormal_cellular_cholesterol2.25111723
19MP0008260_abnormal_autophagy2.19535226
20MP0000609_abnormal_liver_physiology2.11660703
21MP0003868_abnormal_feces_composition2.06037363
22MP0003195_calcinosis2.06034629
23MP0000465_gastrointestinal_hemorrhage2.04345937
24MP0001533_abnormal_skeleton_physiology1.98991827
25MP0002118_abnormal_lipid_homeostasis1.96933906
26MP0005000_abnormal_immune_tolerance1.94726819
27MP0001790_abnormal_immune_system1.93985556
28MP0005387_immune_system_phenotype1.93985556
29MP0002148_abnormal_hypersensitivity_rea1.88710443
30MP0002452_abnormal_antigen_presenting1.86039247
31MP0005451_abnormal_body_composition1.85631897
32MP0001800_abnormal_humoral_immune1.82497624
33MP0002420_abnormal_adaptive_immunity1.80655376
34MP0002723_abnormal_immune_serum1.80271041
35MP0001819_abnormal_immune_cell1.79856175
36MP0000858_altered_metastatic_potential1.75929238
37MP0005058_abnormal_lysosome_morphology1.73688837
38MP0003828_pulmonary_edema1.73298492
39MP0002138_abnormal_hepatobiliary_system1.69513315
40MP0002396_abnormal_hematopoietic_system1.66072831
41MP0002405_respiratory_system_inflammati1.64956241
42MP0003172_abnormal_lysosome_physiology1.64604201
43MP0003183_abnormal_peptide_metabolism1.64479819
44MP0005397_hematopoietic_system_phenotyp1.63829414
45MP0001545_abnormal_hematopoietic_system1.63829414
46MP0005319_abnormal_enzyme/_coenzyme1.60535935
47MP0005076_abnormal_cell_differentiation1.56019226
48MP0008004_abnormal_stomach_pH1.55717481
49MP0009643_abnormal_urine_homeostasis1.52005642
50MP0003566_abnormal_cell_adhesion1.51796449
51MP0001764_abnormal_homeostasis1.51106996
52MP0005584_abnormal_enzyme/coenzyme_acti1.42830644
53MP0001851_eye_inflammation1.36641620
54MP0005671_abnormal_response_to1.35374958
55MP0005164_abnormal_response_to1.35152003
56MP0004883_abnormal_blood_vessel1.34241459
57MP0002398_abnormal_bone_marrow1.31693136
58MP0009333_abnormal_splenocyte_physiolog1.31346070
59MP0000716_abnormal_immune_system1.29923069
60MP0003705_abnormal_hypodermis_morpholog1.29640725
61MP0002998_abnormal_bone_remodeling1.23592822
62MP0003453_abnormal_keratinocyte_physiol1.22885073
63MP0003075_altered_response_to1.17258544
64MP0009697_abnormal_copulation1.17250731
65MP0002429_abnormal_blood_cell1.14359655
66MP0002722_abnormal_immune_system1.13450166
67MP0005023_abnormal_wound_healing1.12508468
68MP0000598_abnormal_liver_morphology1.09181601
69MP0005084_abnormal_gallbladder_morpholo1.07674498
70MP0000689_abnormal_spleen_morphology1.07268099
71MP0005636_abnormal_mineral_homeostasis1.04975311
72MP0010234_abnormal_vibrissa_follicle1.03720959
73MP0004782_abnormal_surfactant_physiolog1.03592993
74MP0004808_abnormal_hematopoietic_stem1.02829861
75MP0005390_skeleton_phenotype1.02485621
76MP0000490_abnormal_crypts_of1.01874871
77MP0002277_abnormal_respiratory_mucosa1.01806898
78MP0002822_catalepsy1.01787769
79MP0005166_decreased_susceptibility_to1.00867740
80MP0005220_abnormal_exocrine_pancreas1.00184314
81MP0003656_abnormal_erythrocyte_physiolo0.99872013
82MP0004264_abnormal_extraembryonic_tissu0.96887085
83MP0004185_abnormal_adipocyte_glucose0.95129805
84MP0003186_abnormal_redox_activity0.94079563
85MP0001853_heart_inflammation0.93875055
86MP0004381_abnormal_hair_follicle0.90595568
87MP0002876_abnormal_thyroid_physiology0.89966171
88MP0010155_abnormal_intestine_physiology0.89474616
89MP0009764_decreased_sensitivity_to0.89450461
90MP0005310_abnormal_salivary_gland0.88666028
91MP0008469_abnormal_protein_level0.87969654
92MP0009642_abnormal_blood_homeostasis0.86755191
93MP0009765_abnormal_xenobiotic_induced0.86322690
94MP0009763_increased_sensitivity_to0.85371911
95MP0000604_amyloidosis0.85268093
96MP0005448_abnormal_energy_balance0.83109540
97MP0000678_abnormal_parathyroid_gland0.82754384
98MP0004947_skin_inflammation0.82255159
99MP0001756_abnormal_urination0.80541429
100MP0000703_abnormal_thymus_morphology0.78210615
101MP0002078_abnormal_glucose_homeostasis0.77387746
102MP0002254_reproductive_system_inflammat0.77235291
103MP0003448_altered_tumor_morphology0.76986317
104MP0002132_abnormal_respiratory_system0.76667882
105MP0003091_abnormal_cell_migration0.76665934
106MP0003878_abnormal_ear_physiology0.75744016
107MP0005377_hearing/vestibular/ear_phenot0.75744016
108MP0005165_increased_susceptibility_to0.75511925
109MP0006036_abnormal_mitochondrial_physio0.75262474
110MP0002136_abnormal_kidney_physiology0.74761876
111MP0003300_gastrointestinal_ulcer0.74535814
112MP0005408_hypopigmentation0.74530046
113MP0003763_abnormal_thymus_physiology0.72917237
114MP0005501_abnormal_skin_physiology0.72856429
115MP0002971_abnormal_brown_adipose0.72309764
116MP0005464_abnormal_platelet_physiology0.72179338
117MP0003795_abnormal_bone_structure0.71144397
118MP0005334_abnormal_fat_pad0.69539992
119MP0001958_emphysema0.69183168
120MP0003011_delayed_dark_adaptation0.65843900
121MP0003866_abnormal_defecation0.64773719
122MP0005647_abnormal_sex_gland0.64519718
123MP0001873_stomach_inflammation0.63254078
124MP0002166_altered_tumor_susceptibility0.62597002
125MP0005376_homeostasis/metabolism_phenot0.61983408
126MP0006035_abnormal_mitochondrial_morpho0.61493095
127MP0001845_abnormal_inflammatory_respons0.60982621
128MP0004043_abnormal_pH_regulation0.60382089
129MP0001663_abnormal_digestive_system0.59787541
130MP0004130_abnormal_muscle_cell0.58471133
131MP0006082_CNS_inflammation0.57528086
132MP0000462_abnormal_digestive_system0.57304841
133MP0005670_abnormal_white_adipose0.56632619
134MP0008872_abnormal_physiological_respon0.55575038
135MP0005535_abnormal_body_temperature0.53878497
136MP0005266_abnormal_metabolism0.52878505
137MP0001765_abnormal_ion_homeostasis0.51979617
138MP0003638_abnormal_response/metabolism_0.51922662
139MP0005381_digestive/alimentary_phenotyp0.50247250
140MP0008873_increased_physiological_sensi0.50200369
141MP0003718_maternal_effect0.50062626
142MP0002796_impaired_skin_barrier0.49833511
143MP0001661_extended_life_span0.49287502
144MP0001243_abnormal_dermal_layer0.48301549
145MP0000685_abnormal_immune_system0.48123222
146MP0003436_decreased_susceptibility_to0.47917324
147MP0001849_ear_inflammation0.47875770
148MP0000477_abnormal_intestine_morphology0.46818569
149MP0009115_abnormal_fat_cell0.45240832
150MP0003724_increased_susceptibility_to0.44242492
151MP0009785_altered_susceptibility_to0.43131316
152MP0003953_abnormal_hormone_level0.42866173
153MP0005167_abnormal_blood-brain_barrier0.41143056
154MP0009053_abnormal_anal_canal0.40712275
155MP0005666_abnormal_adipose_tissue0.39889277
156MP0008961_abnormal_basal_metabolism0.38800951
157MP0003329_amyloid_beta_deposits0.37878157
158MP0005395_other_phenotype0.37128224
159MP0008874_decreased_physiological_sensi0.36377794
160MP0000249_abnormal_blood_vessel0.35741974
161MP0005025_abnormal_response_to0.35313781
162MP0002970_abnormal_white_adipose0.35191174

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)6.76455336
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.62216435
3Deep venous thrombosis (HP:0002625)6.14439283
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.13920557
5Intrahepatic cholestasis (HP:0001406)5.93762573
6Xanthomatosis (HP:0000991)5.71998585
7Eczematoid dermatitis (HP:0000976)5.44167119
8Prolonged partial thromboplastin time (HP:0003645)5.13868723
9Abnormality of glutamine family amino acid metabolism (HP:0010902)5.02066879
10Hyperlipoproteinemia (HP:0010980)4.94828728
11Recurrent abscess formation (HP:0002722)4.90802104
12Hypolipoproteinemia (HP:0010981)4.76916050
13Myositis (HP:0100614)4.72274690
14Recurrent bacterial skin infections (HP:0005406)4.55514507
15Hyperammonemia (HP:0001987)4.49310743
16Hyperglycinuria (HP:0003108)4.46165756
17Abnormality of macrophages (HP:0004311)4.35860950
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.30609814
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.26994255
20Elevated erythrocyte sedimentation rate (HP:0003565)4.26212919
21Fat malabsorption (HP:0002630)4.21547626
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.17924058
23Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.16550856
24Abnormality of glycine metabolism (HP:0010895)4.11346945
25Abnormality of serine family amino acid metabolism (HP:0010894)4.11346945
26Ketosis (HP:0001946)4.03677598
27Abnormal respiratory epithelium morphology (HP:0012253)3.97919291
28Abnormal respiratory motile cilium morphology (HP:0005938)3.97919291
29Conjugated hyperbilirubinemia (HP:0002908)3.96010739
30Hyperglycinemia (HP:0002154)3.93766374
31Absent/shortened dynein arms (HP:0200106)3.90750282
32Dynein arm defect of respiratory motile cilia (HP:0012255)3.90750282
33Epidermoid cyst (HP:0200040)3.90461544
34Abnormality of the common coagulation pathway (HP:0010990)3.77828583
35Hypoalphalipoproteinemia (HP:0003233)3.75832593
36Abnormality of methionine metabolism (HP:0010901)3.75471512
37Joint hemorrhage (HP:0005261)3.74989493
38Nasal polyposis (HP:0100582)3.71702748
39Recurrent gram-negative bacterial infections (HP:0005420)3.64118699
40Abnormal respiratory motile cilium physiology (HP:0012261)3.58684459
41Orchitis (HP:0100796)3.55570853
42Abnormality of pyrimidine metabolism (HP:0004353)3.55327020
43Abnormal ciliary motility (HP:0012262)3.53630107
44Hypoglycemic coma (HP:0001325)3.53547890
45Hypercholesterolemia (HP:0003124)3.53473790
46Abnormality of the nasal mucosa (HP:0000433)3.36489453
47Abnormality of fatty-acid metabolism (HP:0004359)3.32742997
48Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.26605017
49Chronic bronchitis (HP:0004469)3.22326352
50Abnormality of nucleobase metabolism (HP:0010932)3.21810143
51Complement deficiency (HP:0004431)3.18513055
52Rhinitis (HP:0012384)3.16523710
53Malnutrition (HP:0004395)3.15237680
54Acanthocytosis (HP:0001927)3.14800333
55Abnormality of the intrinsic pathway (HP:0010989)3.13373809
56Prolonged bleeding time (HP:0003010)3.13311285
57Petechiae (HP:0000967)3.11612646
58Hyperbilirubinemia (HP:0002904)3.11171462
59Hypoplasia of the thymus (HP:0000778)3.10692242
60Abnormality of purine metabolism (HP:0004352)3.05051705
61Ketoacidosis (HP:0001993)3.04512493
62Chronic obstructive pulmonary disease (HP:0006510)3.01147898
63Obstructive lung disease (HP:0006536)3.01147898
64Interstitial pulmonary disease (HP:0006530)3.00949726
65Spontaneous hematomas (HP:0007420)2.97068498
66Bronchiectasis (HP:0002110)2.94387671
67Metabolic acidosis (HP:0001942)2.92212574
68Steatorrhea (HP:0002570)2.89861944
69Gout (HP:0001997)2.87518006
70Optic neuritis (HP:0100653)2.84671468
71Retrobulbar optic neuritis (HP:0100654)2.84671468
72Cellulitis (HP:0100658)2.84440991
73Gingivitis (HP:0000230)2.83854973
74Increased IgE level (HP:0003212)2.83721558
75T lymphocytopenia (HP:0005403)2.80669566
76Pustule (HP:0200039)2.80168090
77Recurrent skin infections (HP:0001581)2.77143076
78Hydroxyprolinuria (HP:0003080)2.75553858
79Abnormality of proline metabolism (HP:0010907)2.75553858
80Stomatitis (HP:0010280)2.73090964
81Epistaxis (HP:0000421)2.69482117
82Abnormality of serum amino acid levels (HP:0003112)2.69290115
83Delayed CNS myelination (HP:0002188)2.68418219
84Abnormality of T cell number (HP:0011839)2.68097669
85Recurrent sinusitis (HP:0011108)2.67296139
86Recurrent fungal infections (HP:0002841)2.66691750
87Combined immunodeficiency (HP:0005387)2.64482104
88Mediastinal lymphadenopathy (HP:0100721)2.64100577
89Urticaria (HP:0001025)2.63997014
90Ileus (HP:0002595)2.62231411
91Abnormality of dicarboxylic acid metabolism (HP:0010995)2.61803007
92Dicarboxylic aciduria (HP:0003215)2.61803007
93Purpura (HP:0000979)2.61322003
94Increased cerebral lipofuscin (HP:0011813)2.61026578
95Severe combined immunodeficiency (HP:0004430)2.58589474
96Myocardial infarction (HP:0001658)2.54703096
97Hepatocellular carcinoma (HP:0001402)2.54553392
98Meningitis (HP:0001287)2.54459552
99Vascular calcification (HP:0004934)2.54303992
100Lethargy (HP:0001254)2.52376852
101Loss of speech (HP:0002371)2.52362221
102Chronic otitis media (HP:0000389)2.50168541
103Gastrointestinal infarctions (HP:0005244)2.50070671
104Gastrointestinal inflammation (HP:0004386)2.41483551
105Thrombocytosis (HP:0001894)2.39828574
106B lymphocytopenia (HP:0010976)2.39083667
107Abnormality of B cell number (HP:0010975)2.39083667
108Alkalosis (HP:0001948)2.38430399
109Spontaneous abortion (HP:0005268)2.37269833
110Increased serum ferritin (HP:0003281)2.37051753
111Episodic fever (HP:0001954)2.36367676
112Increased neuronal autofluorescent lipopigment (HP:0002074)2.34447951
113Spastic diplegia (HP:0001264)2.32904448
114Poikilocytosis (HP:0004447)2.31677621
115Pancreatitis (HP:0001733)2.29330298
116Polygenic inheritance (HP:0010982)2.28592422
117Esophageal varix (HP:0002040)2.28532747
118Hyperactive renin-angiotensin system (HP:0000841)2.28375524
119Hepatosplenomegaly (HP:0001433)2.27861044
120Irritability (HP:0000737)2.27803642
121Abnormality of complement system (HP:0005339)2.26774927
122Late onset (HP:0003584)2.26479621
123Anorexia (HP:0002039)2.23856961
124Chest pain (HP:0100749)2.23144800
125Cardiovascular calcification (HP:0011915)2.21518155
126Hypoglycemic seizures (HP:0002173)2.21182813
127Skin nodule (HP:0200036)2.20879695
128Distal lower limb muscle weakness (HP:0009053)2.18152626
129Vasculitis (HP:0002633)2.18012893
130Inflammation of the large intestine (HP:0002037)2.17737754
131Peritonitis (HP:0002586)2.13896968
132Premature loss of primary teeth (HP:0006323)2.13531097
133Abnormal cartilage morphology (HP:0002763)2.12490233
134Hypergammaglobulinemia (HP:0010702)2.12193695
135Arterial thrombosis (HP:0004420)2.10951063
136Abnormal delayed hypersensitivity skin test (HP:0002963)2.10191129
137Abnormality of iron homeostasis (HP:0011031)2.08869253
138Glycosuria (HP:0003076)2.07652459
139Abnormality of urine glucose concentration (HP:0011016)2.07652459
140Recurrent otitis media (HP:0000403)2.06735112
141Easy fatigability (HP:0003388)2.06386068
142Male infertility (HP:0003251)2.06090675
143Bronchitis (HP:0012387)2.05801977
144Vomiting (HP:0002013)2.04326154
145Glomerulonephritis (HP:0000099)2.04110745
146Autoimmune thrombocytopenia (HP:0001973)2.03565958
147Generalized aminoaciduria (HP:0002909)2.03103140
148Hyperuricemia (HP:0002149)2.02819465
149Increased purine levels (HP:0004368)2.02819465
150Granulocytopenia (HP:0001913)2.02317408
151Proximal tubulopathy (HP:0000114)2.00484750
152Hypertriglyceridemia (HP:0002155)1.99418329
153Cerebral edema (HP:0002181)1.98958372
154Hypochromic microcytic anemia (HP:0004840)1.98954139
155Osteomyelitis (HP:0002754)1.98859280
156Abnormal tarsal ossification (HP:0008369)1.97031756
157Hemoptysis (HP:0002105)1.96346699
158Flat acetabular roof (HP:0003180)1.95909959
159Menorrhagia (HP:0000132)1.95323631
160Keratoconjunctivitis sicca (HP:0001097)1.95161455
161Brushfield spots (HP:0001088)1.94291744
162Acute hepatic failure (HP:0006554)1.94150457
163Chronic sinusitis (HP:0011109)1.93236658
164Amyloidosis (HP:0011034)1.92606507
165Abnormal platelet volume (HP:0011876)1.91811503
166Encephalitis (HP:0002383)1.91635318
167Abnormality of vitamin metabolism (HP:0100508)1.91585386
168Colitis (HP:0002583)1.90810517
169Gingival bleeding (HP:0000225)1.90654675
170Hypertensive crisis (HP:0100735)1.90494655
171Chronic mucocutaneous candidiasis (HP:0002728)1.90333704
172Recurrent cutaneous fungal infections (HP:0011370)1.90333704
173Abnormal gallbladder morphology (HP:0012437)1.89923294
174Increased mean platelet volume (HP:0011877)1.89415117
175Thyroiditis (HP:0100646)1.88638263
176Cholelithiasis (HP:0001081)1.87012323
177Pulmonary infiltrates (HP:0002113)1.86876357
178Skin ulcer (HP:0200042)1.86528384
179Increased connective tissue (HP:0009025)1.86463216
180Growth hormone excess (HP:0000845)1.85811193
181Eosinophilia (HP:0001880)1.82469595
182Hemorrhage of the eye (HP:0011885)1.82051359
183Neonatal onset (HP:0003623)1.82018613
184Sensorimotor neuropathy (HP:0007141)1.81076832
185Dysostosis multiplex (HP:0000943)1.80969980
186Nephrolithiasis (HP:0000787)1.80644783
187Pulmonary embolism (HP:0002204)1.78771362
188Abnormality of liposaccharide metabolism (HP:0010968)1.77538474
189Abnormality of glycosphingolipid metabolism (HP:0004343)1.77538474
190Abnormality of glycolipid metabolism (HP:0010969)1.77538474
191Widely patent fontanelles and sutures (HP:0004492)1.77485110
192Abnormal vertebral ossification (HP:0100569)1.75545027
193Abnormality of the distal phalanges of the toes (HP:0010182)1.75443669
194Slow saccadic eye movements (HP:0000514)1.73996572

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.84208498
2FGFR43.95754099
3ERN13.61880078
4PKN23.43826519
5GRK63.27388043
6RIPK43.12201283
7MST1R3.08398534
8SIK13.00749467
9FRK2.90517344
10IRAK42.54260408
11TXK2.53617124
12MAP4K12.32367140
13MAP3K102.08271464
14PTK62.05229276
15TYK22.00037263
16MST41.98266921
17TAOK31.95680828
18TRIB31.91187734
19ZAP701.86331092
20FLT31.83139322
21IRAK31.81911495
22BLK1.78864873
23PRPF4B1.74179611
24INSRR1.72955948
25SMG11.72221115
26MAPK151.67672045
27MAP3K71.64076720
28TNK21.54454110
29FGR1.53199314
30STK101.45605304
31MAPK111.41944493
32SIK31.41831292
33ITK1.40951220
34MAP2K21.36587081
35CSK1.36297330
36PAK41.33294974
37BTK1.29321043
38FES1.18317472
39CSF1R1.17657491
40BMX1.12664806
41IRAK21.09811470
42NLK1.08995330
43PRKD21.07400957
44EPHB11.03841689
45PIK3CG1.02787498
46JAK21.00969580
47KDR1.00913338
48MATK1.00836988
49MARK21.00789445
50TBK11.00435809
51MAP2K40.99620860
52MAPK40.99317655
53KIT0.98377830
54MAPK70.97413419
55IRAK10.96291734
56FGFR20.93267303
57PRKAA20.92773829
58FGFR30.91804143
59ICK0.87717747
60MAPK120.85164723
61RIPK10.83762351
62ERBB40.83654946
63IKBKE0.83274821
64LMTK20.80948769
65CDK60.79209841
66PRKCQ0.78399109
67MAP2K60.78254706
68PTK2B0.78027576
69JAK10.76992735
70CDC42BPA0.76985221
71TESK10.76164489
72PRKG20.76032291
73PDGFRB0.74415346
74TAOK20.72887985
75DYRK1B0.72700741
76LYN0.71250691
77LRRK20.70225086
78LATS10.68763599
79MAP3K60.67853954
80MAP3K110.67619091
81MAP2K30.67482819
82EEF2K0.65978232
83MET0.64908345
84MAP3K30.63659621
85NME10.62850210
86NUAK10.62806954
87STK380.61043274
88ERBB20.60878363
89SGK30.60399367
90MAPKAPK20.60389677
91MAP3K130.58659293
92PDK10.57245690
93TTN0.57108185
94PIK3CA0.56264151
95SYK0.56133266
96MAP3K80.54942184
97CDK40.54020926
98TESK20.53668831
99LCK0.52533031
100CDK90.52482132
101MAP3K140.52298102
102HIPK20.52296515
103PTK20.52186429
104PRKAA10.50750788
105CDK120.50442710
106IKBKB0.48553243
107PDK40.48355668
108PDK30.48355668
109PDPK10.47056627
110NME20.46992023
111TAOK10.46695947
112KSR20.46565263
113CSNK1G10.46560113
114MAP3K10.44084212
115PRKCD0.42541935
116PRKACG0.42433838
117FYN0.41805200
118RET0.41419194
119NEK90.41323062
120PRKCZ0.40721794
121PRKCI0.40335442
122AKT30.39701148
123TGFBR20.39402268
124EPHA20.39199990
125ACVR1B0.38937113
126RPS6KL10.38925095
127RPS6KC10.38925095
128DAPK20.37290782
129YES10.37278895
130MAP2K10.37125055
131RPS6KA20.36308269
132MAP3K20.36147853
133ABL20.36022301
134TEC0.35858866
135MAPKAPK30.35352125
136JAK30.35069083
137GRK10.33621778
138CAMK1D0.32758958
139RPS6KB20.32699139
140MTOR0.32473779
141CSNK1A1L0.32017000
142MELK0.31784798
143PRKD10.31426791
144CSNK1G30.31087493
145STK240.30627232
146HCK0.29973079
147IGF1R0.29799963
148GSK3A0.29111396
149STK40.28635653

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.65097334
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.60559028
3Nitrogen metabolism_Homo sapiens_hsa009103.22346244
4Other glycan degradation_Homo sapiens_hsa005112.97648679
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.92034519
6Arginine biosynthesis_Homo sapiens_hsa002202.89936099
7Tryptophan metabolism_Homo sapiens_hsa003802.59852683
8Osteoclast differentiation_Homo sapiens_hsa043802.54043154
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.49306114
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.48291431
11Fatty acid degradation_Homo sapiens_hsa000712.46050296
12Leishmaniasis_Homo sapiens_hsa051402.40549585
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.40113205
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.39956245
15Fat digestion and absorption_Homo sapiens_hsa049752.34725375
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.34198734
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.14054700
18Caffeine metabolism_Homo sapiens_hsa002322.08661195
19Butanoate metabolism_Homo sapiens_hsa006502.03084514
20Complement and coagulation cascades_Homo sapiens_hsa046102.00935146
21Histidine metabolism_Homo sapiens_hsa003402.00749313
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.90374222
23Chemical carcinogenesis_Homo sapiens_hsa052041.89444020
24PPAR signaling pathway_Homo sapiens_hsa033201.87690741
25Propanoate metabolism_Homo sapiens_hsa006401.85837988
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.85501319
27Peroxisome_Homo sapiens_hsa041461.85200090
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.84469282
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.83521729
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.80417836
31Sulfur metabolism_Homo sapiens_hsa009201.79781810
32B cell receptor signaling pathway_Homo sapiens_hsa046621.77348051
33Bile secretion_Homo sapiens_hsa049761.73853464
34Tuberculosis_Homo sapiens_hsa051521.72431220
35Folate biosynthesis_Homo sapiens_hsa007901.72035321
36beta-Alanine metabolism_Homo sapiens_hsa004101.71342440
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.70996516
38Fatty acid metabolism_Homo sapiens_hsa012121.69237231
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.68792650
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.63618316
41Vitamin digestion and absorption_Homo sapiens_hsa049771.62028593
42Allograft rejection_Homo sapiens_hsa053301.58923008
43Hematopoietic cell lineage_Homo sapiens_hsa046401.58856331
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.58682370
45Starch and sucrose metabolism_Homo sapiens_hsa005001.54691762
46Retinol metabolism_Homo sapiens_hsa008301.53948953
47Graft-versus-host disease_Homo sapiens_hsa053321.51954641
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.51098932
49Selenocompound metabolism_Homo sapiens_hsa004501.51055291
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47334461
51Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45042232
52Autoimmune thyroid disease_Homo sapiens_hsa053201.44084759
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.40694135
54Staphylococcus aureus infection_Homo sapiens_hsa051501.38415662
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.38264887
56Malaria_Homo sapiens_hsa051441.37051630
57Pyruvate metabolism_Homo sapiens_hsa006201.35619330
58Influenza A_Homo sapiens_hsa051641.34413990
59Toxoplasmosis_Homo sapiens_hsa051451.33978312
60Platelet activation_Homo sapiens_hsa046111.31905260
61Phenylalanine metabolism_Homo sapiens_hsa003601.31667604
62Lysosome_Homo sapiens_hsa041421.27302355
63Legionellosis_Homo sapiens_hsa051341.27203076
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26779775
65Biosynthesis of amino acids_Homo sapiens_hsa012301.22160420
66Cysteine and methionine metabolism_Homo sapiens_hsa002701.21941387
67NF-kappa B signaling pathway_Homo sapiens_hsa040641.21240071
68Maturity onset diabetes of the young_Homo sapiens_hsa049501.20996929
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.19841203
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.19071616
71ABC transporters_Homo sapiens_hsa020101.18311854
72Viral myocarditis_Homo sapiens_hsa054161.16091994
73Antigen processing and presentation_Homo sapiens_hsa046121.15677006
74Glycerolipid metabolism_Homo sapiens_hsa005611.15552730
75Measles_Homo sapiens_hsa051621.15450767
76Carbon metabolism_Homo sapiens_hsa012001.14730235
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14680624
78Chemokine signaling pathway_Homo sapiens_hsa040621.14657613
79Phagosome_Homo sapiens_hsa041451.14625212
80TNF signaling pathway_Homo sapiens_hsa046681.12659579
81NOD-like receptor signaling pathway_Homo sapiens_hsa046211.10576524
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.10333392
83Arginine and proline metabolism_Homo sapiens_hsa003301.08132609
84Chronic myeloid leukemia_Homo sapiens_hsa052201.07910461
85Fatty acid elongation_Homo sapiens_hsa000621.07004749
86Jak-STAT signaling pathway_Homo sapiens_hsa046301.06158406
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05779718
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04662347
89Herpes simplex infection_Homo sapiens_hsa051681.03267373
90African trypanosomiasis_Homo sapiens_hsa051431.02912994
91Steroid biosynthesis_Homo sapiens_hsa001001.02859867
92Endocytosis_Homo sapiens_hsa041441.02846800
93Notch signaling pathway_Homo sapiens_hsa043301.02750258
94Tyrosine metabolism_Homo sapiens_hsa003501.02614142
95Shigellosis_Homo sapiens_hsa051311.01072700
96Amoebiasis_Homo sapiens_hsa051460.98019893
97Sulfur relay system_Homo sapiens_hsa041220.96645528
98Apoptosis_Homo sapiens_hsa042100.95418531
99Pancreatic cancer_Homo sapiens_hsa052120.94162151
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93924820
101Salmonella infection_Homo sapiens_hsa051320.92958659
102Lysine degradation_Homo sapiens_hsa003100.90740274
103Pertussis_Homo sapiens_hsa051330.89982659
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86878164
105Non-small cell lung cancer_Homo sapiens_hsa052230.86071741
106Type I diabetes mellitus_Homo sapiens_hsa049400.85515896
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81065410
108Hepatitis B_Homo sapiens_hsa051610.79994480
109Asthma_Homo sapiens_hsa053100.79979487
110Glutathione metabolism_Homo sapiens_hsa004800.79509098
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78592223
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78206357
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76345692
114Pentose phosphate pathway_Homo sapiens_hsa000300.74887191
115Renin-angiotensin system_Homo sapiens_hsa046140.72735208
116VEGF signaling pathway_Homo sapiens_hsa043700.72225521
117Choline metabolism in cancer_Homo sapiens_hsa052310.71395889
118AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70826126
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70281442
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.70197725
121Galactose metabolism_Homo sapiens_hsa000520.68731140
122Rheumatoid arthritis_Homo sapiens_hsa053230.66937684
123Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65191669
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62677863
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61705556
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.60693609
127Sphingolipid metabolism_Homo sapiens_hsa006000.60433176
128One carbon pool by folate_Homo sapiens_hsa006700.60051089
129Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58890912
130Central carbon metabolism in cancer_Homo sapiens_hsa052300.58722993
131SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58685507
132Fructose and mannose metabolism_Homo sapiens_hsa000510.57940502
133Primary immunodeficiency_Homo sapiens_hsa053400.54562307
134Renal cell carcinoma_Homo sapiens_hsa052110.54196557
135Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53522389
136Inositol phosphate metabolism_Homo sapiens_hsa005620.52943708
137Endometrial cancer_Homo sapiens_hsa052130.51667749
138Vitamin B6 metabolism_Homo sapiens_hsa007500.50602083
139Neurotrophin signaling pathway_Homo sapiens_hsa047220.50542514
140Mineral absorption_Homo sapiens_hsa049780.49861593
141Bladder cancer_Homo sapiens_hsa052190.49202402
142Metabolic pathways_Homo sapiens_hsa011000.45066583
143Protein digestion and absorption_Homo sapiens_hsa049740.39668495
144alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35441462
145Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34146213
146Glycerophospholipid metabolism_Homo sapiens_hsa005640.32336587
147Fatty acid biosynthesis_Homo sapiens_hsa000610.30823379
148Linoleic acid metabolism_Homo sapiens_hsa005910.29153323
149Insulin resistance_Homo sapiens_hsa049310.25315756
150Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21064447
151Adipocytokine signaling pathway_Homo sapiens_hsa049200.13673652
152Pancreatic secretion_Homo sapiens_hsa049720.13285800
153Intestinal immune network for IgA production_Homo sapiens_hsa046720.08502227
154AMPK signaling pathway_Homo sapiens_hsa041520.00731072
155Acute myeloid leukemia_Homo sapiens_hsa05221-0.2122689
156Prion diseases_Homo sapiens_hsa05020-0.2034151
157Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2011638
158Regulation of autophagy_Homo sapiens_hsa04140-0.1920802
159Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1578661
160Insulin signaling pathway_Homo sapiens_hsa04910-0.1289503
161Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1113443
162Hepatitis C_Homo sapiens_hsa05160-0.0912725
163Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0911055
164Thyroid cancer_Homo sapiens_hsa05216-0.0756970
165Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0565768
166Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0519922
167Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.0406663
168Glucagon signaling pathway_Homo sapiens_hsa04922-0.0308062
169Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0224051
170T cell receptor signaling pathway_Homo sapiens_hsa04660-0.0065900

Most similar genes based on co-expression Upload to Enrichr

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