ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nuclear pore complex assembly (GO:0051292)	7.71672723
2	nuclear pore organization (GO:0006999)	6.57171311
3	DNA replication initiation (GO:0006270)	5.83915795
4	regulation of translational fidelity (GO:0006450)	5.83540907
5	pore complex assembly (GO:0046931)	5.47703167
6	DNA unwinding involved in DNA replication (GO:0006268)	5.24914501
7	negative regulation of DNA repair (GO:0045738)	5.24563973
8	regulation of histone H3-K27 methylation (GO:0061085)	5.00951736
9	mitotic chromosome condensation (GO:0007076)	4.66045905
10	regulation of RNA export from nucleus (GO:0046831)	4.57707315
11	DNA topological change (GO:0006265)	4.05447865
12	mRNA cleavage (GO:0006379)	4.00311025
13	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.83912112
14	mitotic sister chromatid segregation (GO:0000070)	3.83116320
15	sister chromatid segregation (GO:0000819)	3.82624266
16	DNA duplex unwinding (GO:0032508)	3.80300058
17	negative regulation of histone methylation (GO:0031061)	3.79958676
18	DNA synthesis involved in DNA repair (GO:0000731)	3.77445862
19	regulation of nucleobase-containing compound transport (GO:0032239)	3.72642323
20	mitotic nuclear envelope disassembly (GO:0007077)	3.68875970
21	DNA geometric change (GO:0032392)	3.60947381
22	mitotic sister chromatid cohesion (GO:0007064)	3.57122936
23	positive regulation of transcription from RNA polymerase III promoter (GO:0045945)	3.54697787
24	regulation of histone H3-K4 methylation (GO:0051569)	3.44210839
25	membrane disassembly (GO:0030397)	3.43062364
26	nuclear envelope disassembly (GO:0051081)	3.43062364
27	folic acid-containing compound biosynthetic process (GO:0009396)	3.42742866
28	regulation of double-strand break repair (GO:2000779)	3.40833474
29	regulation of translational elongation (GO:0006448)	3.36739857
30	formation of translation preinitiation complex (GO:0001731)	3.36187070
31	regulation of NFAT protein import into nucleus (GO:0051532)	3.34945516
32	DNA conformation change (GO:0071103)	3.34366292
33	chromosome condensation (GO:0030261)	3.27515268
34	protein export from nucleus (GO:0006611)	3.26283219
35	heterochromatin organization (GO:0070828)	3.26064011
36	mRNA stabilization (GO:0048255)	3.25140192
37	RNA stabilization (GO:0043489)	3.25140192
38	proline biosynthetic process (GO:0006561)	3.23781272
39	response to laminar fluid shear stress (GO:0034616)	3.23751716
40	ribosomal small subunit biogenesis (GO:0042274)	3.18611297
41	DNA strand elongation involved in DNA replication (GO:0006271)	3.18253185
42	positive regulation of protein import into nucleus, translocation (GO:0033160)	3.17814304
43	peptidyl-lysine dimethylation (GO:0018027)	3.17593835
44	COPII vesicle coating (GO:0048208)	3.13807376
45	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.12391051
46	regulation of histone methylation (GO:0031060)	3.10725992
47	DNA strand elongation (GO:0022616)	3.10677318
48	regulation of centriole replication (GO:0046599)	3.09795727
49	glucocorticoid receptor signaling pathway (GO:0042921)	3.03811938
50	pre-miRNA processing (GO:0031054)	3.00672503
51	poly(A)+ mRNA export from nucleus (GO:0016973)	2.98710887
52	histone deubiquitination (GO:0016578)	2.98194489
53	spliceosomal tri-snRNP complex assembly (GO:0000244)	2.91435393
54	COPI coating of Golgi vesicle (GO:0048205)	2.88384165
55	Golgi transport vesicle coating (GO:0048200)	2.88384165
56	DNA packaging (GO:0006323)	2.87581433
57	histone H3-K4 trimethylation (GO:0080182)	2.86003346
58	mRNA transport (GO:0051028)	2.84287295
59	DNA replication checkpoint (GO:0000076)	2.83121890
60	cytoplasmic mRNA processing body assembly (GO:0033962)	2.82537752
61	monoubiquitinated protein deubiquitination (GO:0035520)	2.81596980
62	definitive hemopoiesis (GO:0060216)	2.81546685
63	tetrahydrofolate metabolic process (GO:0046653)	2.81267992
64	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	2.80841196
65	nuclear envelope organization (GO:0006998)	2.80406302
66	homocysteine metabolic process (GO:0050667)	2.80365266
67	folic acid metabolic process (GO:0046655)	2.79643328
68	histone H3-K9 demethylation (GO:0033169)	2.78589403
69	iron ion import (GO:0097286)	2.76423227
70	protoporphyrinogen IX metabolic process (GO:0046501)	2.75891708
71	regulation of centrosome cycle (GO:0046605)	2.70431849
72	histone H3-K4 methylation (GO:0051568)	2.70129302
73	establishment of mitotic spindle localization (GO:0040001)	2.68518579
74	dosage compensation (GO:0007549)	2.67434596
75	histone H3-K36 demethylation (GO:0070544)	2.66549248
76	TOR signaling (GO:0031929)	2.65869049
77	cranial suture morphogenesis (GO:0060363)	2.64203297
78	regulation of centrosome duplication (GO:0010824)	2.63829965
79	corticosteroid receptor signaling pathway (GO:0031958)	2.62375726
80	peptidyl-arginine omega-N-methylation (GO:0035247)	2.58140473
81	telomere maintenance via semi-conservative replication (GO:0032201)	2.56896093
82	response to vitamin A (GO:0033189)	2.55891037
83	protein localization to chromosome, centromeric region (GO:0071459)	2.55751568
84	folic acid-containing compound metabolic process (GO:0006760)	2.55047976
85	maturation of SSU-rRNA (GO:0030490)	2.53822799
86	positive regulation of cell cycle checkpoint (GO:1901978)	2.53532082
87	mannose metabolic process (GO:0006013)	2.53137990
88	negative regulation of fatty acid biosynthetic process (GO:0045717)	2.52253405
89	response to epidermal growth factor (GO:0070849)	2.51862165
90	regulation of mitotic spindle organization (GO:0060236)	2.51831238
91	double-strand break repair via nonhomologous end joining (GO:0006303)	2.50768554
92	non-recombinational repair (GO:0000726)	2.50768554
93	IMP biosynthetic process (GO:0006188)	2.50114792
94	mRNA export from nucleus (GO:0006406)	2.49432696
95	spindle organization (GO:0007051)	2.47299493
96	embryonic process involved in female pregnancy (GO:0060136)	2.46536926
97	protein-DNA complex disassembly (GO:0032986)	2.45702782
98	nucleosome disassembly (GO:0006337)	2.45702782
99	establishment of RNA localization (GO:0051236)	2.44949542
100	nucleic acid transport (GO:0050657)	2.44949542

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	9.26415550
2	FOXM1_23109430_ChIP-Seq_U2OS_Human	4.46314295
3	MYC_22102868_ChIP-Seq_BL_Human	3.44258724
4	EGR1_19374776_ChIP-ChIP_THP-1_Human	3.11125296
5	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.92295747
6	ZNF263_19887448_ChIP-Seq_K562_Human	2.73610364
7	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.65479251
8	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.63078067
9	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	2.53957351
10	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.41338556
11	E2F1_21310950_ChIP-Seq_MCF-7_Human	2.36656504
12	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.33825293
13	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.33664412
14	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.32829006
15	AR_21909140_ChIP-Seq_LNCAP_Human	2.32285662
16	VDR_21846776_ChIP-Seq_THP-1_Human	2.15137250
17	XRN2_22483619_ChIP-Seq_HELA_Human	2.06273658
18	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.04263166
19	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.03640168
20	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.94957282
21	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.93858897
22	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.91719156
23	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.86371802
24	KDM5A_27292631_Chip-Seq_BREAST_Human	1.85447920
25	CIITA_25753668_ChIP-Seq_RAJI_Human	1.85098209
26	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.74235031
27	GATA1_22025678_ChIP-Seq_K562_Human	1.73810332
28	NCOR1_26117541_ChIP-Seq_K562_Human	1.71467710
29	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.67598867
30	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.63303658
31	DCP1A_22483619_ChIP-Seq_HELA_Human	1.62630269
32	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.61510731
33	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.59305602
34	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.58797824
35	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.57284470
36	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.52924538
37	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.50765329
38	CHD1_26751641_Chip-Seq_LNCaP_Human	1.46491086
39	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.44643159
40	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.44313831
41	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.44125857
42	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.41463668
43	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.40069930
44	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.37340384
45	RACK7_27058665_Chip-Seq_MCF-7_Human	1.36953899
46	TTF2_22483619_ChIP-Seq_HELA_Human	1.34673444
47	TCF7_22412390_ChIP-Seq_EML_Mouse	1.34115093
48	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.33938647
49	CLOCK_20551151_ChIP-Seq_293T_Human	1.33315953
50	TFEB_21752829_ChIP-Seq_HELA_Human	1.30768797
51	KDM2B_26808549_Chip-Seq_DND41_Human	1.29511141
52	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.29279621
53	GABP_19822575_ChIP-Seq_HepG2_Human	1.25921991
54	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.25763334
55	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.24143734
56	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.24122115
57	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.21244306
58	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.20815304
59	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.20324862
60	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.20001877
61	MAF_26560356_Chip-Seq_TH1_Human	1.19851594
62	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.16512943
63	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.15576364
64	LXR_22292898_ChIP-Seq_THP-1_Human	1.15482726
65	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.15003385
66	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.15001481
67	MAF_26560356_Chip-Seq_TH2_Human	1.13824211
68	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	1.12660552
69	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.11940002
70	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.11500460
71	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.11430031
72	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.09861710
73	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.08552678
74	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.08085809
75	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.04690324
76	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.04352022
77	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.03969622
78	GATA6_25053715_ChIP-Seq_YYC3_Human	1.03761263
79	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.03536434
80	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.03358287
81	ATF3_27146783_Chip-Seq_COLON_Human	1.02739222
82	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.02344595
83	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.00401755
84	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	0.98054433
85	KDM2B_26808549_Chip-Seq_SUP-B15_Human	0.97479065
86	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.97322316
87	KDM2B_26808549_Chip-Seq_JURKAT_Human	0.97270147
88	CREB1_26743006_Chip-Seq_LNCaP_Human	0.95873353
89	UBF1/2_26484160_Chip-Seq_HMECs_Human	0.92921628
90	GATA1_19941826_ChIP-Seq_K562_Human	0.92562772
91	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.91990285
92	NANOG_21062744_ChIP-ChIP_HESCs_Human	0.91401625
93	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.90789294
94	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.90563321
95	UTX_26944678_Chip-Seq_JUKART_Human	0.89885435
96	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.89798435
97	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	0.89047072
98	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.87636109
99	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.86976703
100	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.86242781

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	3.91332412
2	MP0002009_preneoplasia	3.38952223
3	MP0003111_abnormal_nucleus_morphology	3.22611197
4	MP0010094_abnormal_chromosome_stability	3.11597442
5	MP0005451_abnormal_body_composition	3.09887563
6	MP0005076_abnormal_cell_differentiation	2.85897941
7	MP0003077_abnormal_cell_cycle	2.64520676
8	MP0002877_abnormal_melanocyte_morpholog	2.57468487
9	MP0003693_abnormal_embryo_hatching	2.54191399
10	MP0000537_abnormal_urethra_morphology	2.51237307
11	MP0004957_abnormal_blastocyst_morpholog	2.45451942
12	MP0002396_abnormal_hematopoietic_system	2.33513461
13	MP0008007_abnormal_cellular_replicative	2.24604917
14	MP0004233_abnormal_muscle_weight	2.22910682
15	MP0005058_abnormal_lysosome_morphology	2.03709051
16	MP0008995_early_reproductive_senescence	2.03329217
17	MP0003315_abnormal_perineum_morphology	1.98654470
18	MP0004808_abnormal_hematopoietic_stem	1.97628347
19	MP0001730_embryonic_growth_arrest	1.87091978
20	MP0001346_abnormal_lacrimal_gland	1.82814784
21	MP0001661_extended_life_span	1.81112802
22	MP0008058_abnormal_DNA_repair	1.80672384
23	MP0003705_abnormal_hypodermis_morpholog	1.80385588
24	MP0000350_abnormal_cell_proliferation	1.73037467
25	MP0009697_abnormal_copulation	1.71245225
26	MP0003984_embryonic_growth_retardation	1.69853546
27	MP0002088_abnormal_embryonic_growth/wei	1.67338265
28	MP0004185_abnormal_adipocyte_glucose	1.65519142
29	MP0001672_abnormal_embryogenesis/_devel	1.61719994
30	MP0005380_embryogenesis_phenotype	1.61719994
31	MP0003656_abnormal_erythrocyte_physiolo	1.60809994
32	MP0010307_abnormal_tumor_latency	1.60126666
33	MP0005409_darkened_coat_color	1.52719896
34	MP0004264_abnormal_extraembryonic_tissu	1.49238843
35	MP0002086_abnormal_extraembryonic_tissu	1.45002320
36	MP0005248_abnormal_Harderian_gland	1.44080126
37	MP0010030_abnormal_orbit_morphology	1.41689208
38	MP0001697_abnormal_embryo_size	1.40175899
39	MP0008932_abnormal_embryonic_tissue	1.39788171
40	MP0002080_prenatal_lethality	1.36659763
41	MP0005187_abnormal_penis_morphology	1.36323545
42	MP0002132_abnormal_respiratory_system	1.35284370
43	MP0003942_abnormal_urinary_system	1.34151470
44	MP0010234_abnormal_vibrissa_follicle	1.31192252
45	MP0010352_gastrointestinal_tract_polyps	1.30397588
46	MP0000003_abnormal_adipose_tissue	1.28995842
47	MP0005408_hypopigmentation	1.27167733
48	MP0003786_premature_aging	1.26194318
49	MP0008961_abnormal_basal_metabolism	1.21877332
50	MP0004197_abnormal_fetal_growth/weight/	1.17181181
51	MP0003172_abnormal_lysosome_physiology	1.15258851
52	MP0002084_abnormal_developmental_patter	1.13542533
53	MP0002166_altered_tumor_susceptibility	1.12883457
54	MP0002249_abnormal_larynx_morphology	1.12816192
55	MP0000313_abnormal_cell_death	1.12097041
56	MP0010630_abnormal_cardiac_muscle	1.07830059
57	MP0001915_intracranial_hemorrhage	1.07243618
58	MP0002085_abnormal_embryonic_tissue	1.06804557
59	MP0000747_muscle_weakness	1.02756432
60	MP0002269_muscular_atrophy	1.01733776
61	MP0003938_abnormal_ear_development	0.98505958
62	MP0003115_abnormal_respiratory_system	0.97434645
63	MP0003385_abnormal_body_wall	0.96599260
64	MP0002697_abnormal_eye_size	0.94331644
65	MP0005083_abnormal_biliary_tract	0.92940398
66	MP0004084_abnormal_cardiac_muscle	0.91397663
67	MP0003890_abnormal_embryonic-extraembry	0.90620079
68	MP0009672_abnormal_birth_weight	0.90209190
69	MP0000733_abnormal_muscle_development	0.88420136
70	MP0000383_abnormal_hair_follicle	0.86852332
71	MP0001545_abnormal_hematopoietic_system	0.86267568
72	MP0005397_hematopoietic_system_phenotyp	0.86267568
73	MP0009703_decreased_birth_body	0.85637253
74	MP0005220_abnormal_exocrine_pancreas	0.84813149
75	MP0005621_abnormal_cell_physiology	0.84073342
76	MP0006035_abnormal_mitochondrial_morpho	0.83479983
77	MP0002970_abnormal_white_adipose	0.82196056
78	MP0002019_abnormal_tumor_incidence	0.82144371
79	MP0000534_abnormal_ureter_morphology	0.81777149
80	MP0000358_abnormal_cell_content/	0.81304078
81	MP0002092_abnormal_eye_morphology	0.80848829
82	MP0005375_adipose_tissue_phenotype	0.78913105
83	MP0003221_abnormal_cardiomyocyte_apopto	0.78574549
84	MP0003937_abnormal_limbs/digits/tail_de	0.78335996
85	MP0010678_abnormal_skin_adnexa	0.78143777
86	MP0005384_cellular_phenotype	0.77941938
87	MP0000678_abnormal_parathyroid_gland	0.77781539
88	MP0000566_synostosis	0.75640136
89	MP0004087_abnormal_muscle_fiber	0.75063298
90	MP0002108_abnormal_muscle_morphology	0.74317136
91	MP0001849_ear_inflammation	0.73952132
92	MP0009115_abnormal_fat_cell	0.72449859
93	MP0000609_abnormal_liver_physiology	0.72269480
94	MP0000598_abnormal_liver_morphology	0.71960238
95	MP0001348_abnormal_lacrimal_gland	0.71874259
96	MP0000759_abnormal_skeletal_muscle	0.71622190
97	MP0003943_abnormal_hepatobiliary_system	0.70913694
98	MP0004036_abnormal_muscle_relaxation	0.70077489
99	MP0005666_abnormal_adipose_tissue	0.69657229
100	MP0000703_abnormal_thymus_morphology	0.68485739

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Dysmetric saccades (HP:0000641)	3.79674484
2	Chromsome breakage (HP:0040012)	3.73342707
3	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.34783043
4	Poikiloderma (HP:0001029)	3.07397437
5	Acanthocytosis (HP:0001927)	2.98452661
6	Deep venous thrombosis (HP:0002625)	2.96768970
7	Reticulocytosis (HP:0001923)	2.91158071
8	Abnormality of the fingertips (HP:0001211)	2.81705206
9	Right ventricular cardiomyopathy (HP:0011663)	2.78668943
10	Sparse lateral eyebrow (HP:0005338)	2.75979952
11	Ulnar bowing (HP:0003031)	2.71651621
12	Microvesicular hepatic steatosis (HP:0001414)	2.67118510
13	Septate vagina (HP:0001153)	2.64550389
14	Overlapping toe (HP:0001845)	2.63752383
15	Asymmetry of the thorax (HP:0001555)	2.56908911
16	Ankyloglossia (HP:0010296)	2.51020134
17	Broad palm (HP:0001169)	2.50034850
18	Abnormality of reticulocytes (HP:0004312)	2.49404709
19	Abnormality of homocysteine metabolism (HP:0010919)	2.48873622
20	Homocystinuria (HP:0002156)	2.48873622
21	Acute myeloid leukemia (HP:0004808)	2.43579680
22	Flat acetabular roof (HP:0003180)	2.41980009
23	Deviation of the thumb (HP:0009603)	2.41612675
24	Proximal placement of thumb (HP:0009623)	2.37446499
25	High anterior hairline (HP:0009890)	2.36790210
26	Deep palmar crease (HP:0006191)	2.30559702
27	Progressive external ophthalmoplegia (HP:0000590)	2.30463395
28	Deep philtrum (HP:0002002)	2.29362430
29	Capillary hemangiomas (HP:0005306)	2.28246908
30	11 pairs of ribs (HP:0000878)	2.28000576
31	Heterotopia (HP:0002282)	2.26936555
32	Abnormal gallbladder physiology (HP:0012438)	2.26317337
33	Cholecystitis (HP:0001082)	2.26317337
34	Long eyelashes (HP:0000527)	2.25536330
35	Birth length less than 3rd percentile (HP:0003561)	2.24987517
36	Abnormality of cochlea (HP:0000375)	2.23214642
37	Limited elbow extension (HP:0001377)	2.21211949
38	Hyperacusis (HP:0010780)	2.18881393
39	Abnormality of the intrinsic pathway (HP:0010989)	2.16076209
40	Entropion (HP:0000621)	2.09921909
41	Self-mutilation (HP:0000742)	2.09331207
42	Colitis (HP:0002583)	2.06297646
43	Progressive muscle weakness (HP:0003323)	2.06112049
44	Decreased lacrimation (HP:0000633)	2.04340889
45	Hypobetalipoproteinemia (HP:0003563)	1.99810871
46	Sandal gap (HP:0001852)	1.97758612
47	Anal stenosis (HP:0002025)	1.96149090
48	Missing ribs (HP:0000921)	1.94609089
49	Pancreatic islet-cell hyperplasia (HP:0004510)	1.93827735
50	Poikilocytosis (HP:0004447)	1.93482877
51	Increased nuchal translucency (HP:0010880)	1.93475653
52	Prolonged partial thromboplastin time (HP:0003645)	1.93266419
53	Abnormality of the thoracic spine (HP:0100711)	1.92602993
54	Dislocated radial head (HP:0003083)	1.91127056
55	Abnormal foot bone ossification (HP:0010675)	1.89804966
56	Prominent nose (HP:0000448)	1.89476267
57	Abnormality of the calcaneus (HP:0008364)	1.88618538
58	Thoracic kyphosis (HP:0002942)	1.87827001
59	Obsessive-compulsive behavior (HP:0000722)	1.85972228
60	Abnormality of oral frenula (HP:0000190)	1.85365726
61	Duplication of thumb phalanx (HP:0009942)	1.82845812
62	Centrally nucleated skeletal muscle fibers (HP:0003687)	1.82792296
63	Truncus arteriosus (HP:0001660)	1.81989756
64	Abnormality of chromosome stability (HP:0003220)	1.81175627
65	Submucous cleft hard palate (HP:0000176)	1.79418661
66	Termporal pattern (HP:0011008)	1.79083271
67	Insidious onset (HP:0003587)	1.79083271
68	Facial hemangioma (HP:0000329)	1.78686276
69	Absent radius (HP:0003974)	1.78470361
70	Cafe-au-lait spot (HP:0000957)	1.78237274
71	Small epiphyses (HP:0010585)	1.77794769
72	Abnormality of the radial head (HP:0003995)	1.77723873
73	Anteriorly placed anus (HP:0001545)	1.77419469
74	Hemorrhage of the eye (HP:0011885)	1.76697512
75	Bowel incontinence (HP:0002607)	1.76565125
76	Seborrheic dermatitis (HP:0001051)	1.75726034
77	Alacrima (HP:0000522)	1.75663200
78	Cerebral aneurysm (HP:0004944)	1.74740968
79	Abnormality of the columella (HP:0009929)	1.72792062
80	Low anterior hairline (HP:0000294)	1.72773418
81	Hypoparathyroidism (HP:0000829)	1.72008679
82	Tapered finger (HP:0001182)	1.70800760
83	Broad alveolar ridges (HP:0000187)	1.70158392
84	Myelodysplasia (HP:0002863)	1.69617691
85	Macroorchidism (HP:0000053)	1.69258755
86	Increased number of teeth (HP:0011069)	1.68951976
87	Premature skin wrinkling (HP:0100678)	1.68719750
88	Atelectasis (HP:0100750)	1.67237802
89	Bifid scrotum (HP:0000048)	1.67085931
90	Squamous cell carcinoma (HP:0002860)	1.66779305
91	Nasolacrimal duct obstruction (HP:0000579)	1.66416656
92	Abnormally folded helix (HP:0008544)	1.65674147
93	Disproportionate tall stature (HP:0001519)	1.64481411
94	Abnormality of the common coagulation pathway (HP:0010990)	1.64290345
95	Relative macrocephaly (HP:0004482)	1.63328936
96	Broad face (HP:0000283)	1.63318223
97	Orthostatic hypotension (HP:0001278)	1.63289878
98	Abnormal large intestine physiology (HP:0012700)	1.63262268
99	Biconcave vertebral bodies (HP:0004586)	1.62538270
100	Premature ovarian failure (HP:0008209)	1.62202446

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK12	5.08234089
2	EEF2K	3.98928128
3	ICK	3.51605340
4	TRIB3	3.36912250
5	NEK2	2.85446300
6	BRD4	2.23869273
7	MAP3K10	2.12396823
8	AKT3	2.11374812
9	CAMK1G	1.95891751
10	MST1R	1.92553800
11	IRAK3	1.87217953
12	SCYL2	1.81308725
13	CDC7	1.78288584
14	SRPK1	1.76720596
15	RPS6KB2	1.75810050
16	EIF2AK1	1.67096819
17	LATS1	1.63625753
18	PKN2	1.62196207
19	CAMK1D	1.54101586
20	SMG1	1.47916611
21	SIK1	1.47036628
22	RIPK4	1.43972715
23	MTOR	1.41808834
24	KSR2	1.30509240
25	NME2	1.28259453
26	FGFR4	1.26689275
27	TTK	1.24912026
28	WNK4	1.22352573
29	WNK1	1.18190863
30	CDK4	1.18035464
31	MAPK11	1.17358663
32	PNCK	1.16581725
33	LATS2	1.13737516
34	CDK7	1.08869053
35	CLK1	1.08741407
36	CHEK1	1.04647589
37	ATR	1.03193643
38	ERN1	1.03140954
39	RIPK1	1.02352758
40	BRSK2	1.02052588
41	SIK2	1.01891233
42	MARK3	1.01144455
43	BMPR2	0.98651654
44	CDK6	0.96784328
45	FGFR2	0.95762204
46	MAP3K13	0.89044131
47	MAP2K3	0.88890174
48	BLK	0.86279758
49	PBK	0.83410290
50	CHEK2	0.83360613
51	RPS6KA4	0.83003432
52	MAP3K7	0.82716101
53	PAK2	0.81030652
54	PRPF4B	0.79414135
55	PDGFRA	0.75423679
56	CDK2	0.75103314
57	CDK8	0.74240293
58	FGFR3	0.73352115
59	CDK1	0.72569045
60	PDK2	0.71535770
61	ATM	0.69727743
62	SGK3	0.69427495
63	AURKB	0.66213182
64	TRPM7	0.65789285
65	RAF1	0.65610851
66	RPS6KB1	0.64987788
67	MAPK15	0.64909302
68	MAP3K8	0.64378986
69	WEE1	0.64305747
70	MAP3K2	0.62702370
71	RET	0.62238581
72	MAP3K6	0.61798810
73	MELK	0.59881748
74	SGK2	0.57401389
75	CDK3	0.57224219
76	PINK1	0.57148117
77	CDC42BPA	0.56813195
78	AKT2	0.55384503
79	BRSK1	0.53789761
80	MAPK10	0.52819700
81	PRKAA2	0.52753728
82	FGFR1	0.52349535
83	ALK	0.52190986
84	SGK223	0.50516388
85	SGK494	0.50516388
86	PDPK1	0.50047136
87	PLK4	0.49894211
88	MAP3K14	0.48310226
89	MAPK14	0.47020609
90	NEK1	0.45692198
91	BMX	0.45640216
92	EIF2AK3	0.43843831
93	TSSK6	0.43018583
94	AKT1	0.42728388
95	PRKAA1	0.42595954
96	NEK6	0.41662581
97	MKNK1	0.38891873
98	GSK3B	0.38838206
99	IRAK2	0.38106726
100	PASK	0.36691784

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	3.08470220
2	DNA replication_Homo sapiens_hsa03030	2.72240851
3	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.58924172
4	One carbon pool by folate_Homo sapiens_hsa00670	2.55328763
5	mRNA surveillance pathway_Homo sapiens_hsa03015	2.45453200
6	Cell cycle_Homo sapiens_hsa04110	2.08726467
7	RNA transport_Homo sapiens_hsa03013	2.07510577
8	Chronic myeloid leukemia_Homo sapiens_hsa05220	2.05379103
9	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.90825335
10	Lysine degradation_Homo sapiens_hsa00310	1.89280048
11	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.86481518
12	Non-homologous end-joining_Homo sapiens_hsa03450	1.86093536
13	Non-small cell lung cancer_Homo sapiens_hsa05223	1.83962645
14	Spliceosome_Homo sapiens_hsa03040	1.83062478
15	mTOR signaling pathway_Homo sapiens_hsa04150	1.68180515
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.61214890
17	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.60242988
18	Pancreatic cancer_Homo sapiens_hsa05212	1.59817310
19	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.52850242
20	Other glycan degradation_Homo sapiens_hsa00511	1.48376840
21	Nucleotide excision repair_Homo sapiens_hsa03420	1.46805012
22	Acute myeloid leukemia_Homo sapiens_hsa05221	1.45864140
23	Mismatch repair_Homo sapiens_hsa03430	1.41807418
24	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.40583225
25	Thyroid cancer_Homo sapiens_hsa05216	1.40020820
26	Pentose phosphate pathway_Homo sapiens_hsa00030	1.36720923
27	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.29633667
28	Prostate cancer_Homo sapiens_hsa05215	1.29389690
29	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.27979014
30	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.25559044
31	Homologous recombination_Homo sapiens_hsa03440	1.21249019
32	Small cell lung cancer_Homo sapiens_hsa05222	1.21004980
33	Arginine biosynthesis_Homo sapiens_hsa00220	1.20549258
34	Bladder cancer_Homo sapiens_hsa05219	1.19920412
35	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.17480348
36	MicroRNAs in cancer_Homo sapiens_hsa05206	1.15057971
37	Renal cell carcinoma_Homo sapiens_hsa05211	1.14767945
38	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.13654249
39	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.12043760
40	Base excision repair_Homo sapiens_hsa03410	1.11395802
41	Insulin signaling pathway_Homo sapiens_hsa04910	1.10657588
42	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.09478907
43	Sulfur relay system_Homo sapiens_hsa04122	1.08093783
44	Carbon metabolism_Homo sapiens_hsa01200	1.05616292
45	Viral carcinogenesis_Homo sapiens_hsa05203	1.04890284
46	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.04158674
47	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.00992191
48	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.99829140
49	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.97664558
50	AMPK signaling pathway_Homo sapiens_hsa04152	0.97153241
51	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.95824621
52	Hepatitis B_Homo sapiens_hsa05161	0.94760171
53	Endometrial cancer_Homo sapiens_hsa05213	0.94488209
54	Glioma_Homo sapiens_hsa05214	0.94309889
55	Colorectal cancer_Homo sapiens_hsa05210	0.92975314
56	ErbB signaling pathway_Homo sapiens_hsa04012	0.90456412
57	FoxO signaling pathway_Homo sapiens_hsa04068	0.87905054
58	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.81606854
59	Insulin resistance_Homo sapiens_hsa04931	0.79907157
60	Complement and coagulation cascades_Homo sapiens_hsa04610	0.79541684
61	Pyruvate metabolism_Homo sapiens_hsa00620	0.77702746
62	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.77123487
63	VEGF signaling pathway_Homo sapiens_hsa04370	0.76934303
64	Selenocompound metabolism_Homo sapiens_hsa00450	0.76141983
65	Type II diabetes mellitus_Homo sapiens_hsa04930	0.75513302
66	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.72526642
67	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.72418453
68	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.72049233
69	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.71988270
70	Herpes simplex infection_Homo sapiens_hsa05168	0.67806650
71	Adherens junction_Homo sapiens_hsa04520	0.66544268
72	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.65733667
73	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.65682171
74	HTLV-I infection_Homo sapiens_hsa05166	0.65216260
75	Choline metabolism in cancer_Homo sapiens_hsa05231	0.64847741
76	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.60446413
77	ABC transporters_Homo sapiens_hsa02010	0.60156426
78	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.58382244
79	Oocyte meiosis_Homo sapiens_hsa04114	0.56477703
80	Apoptosis_Homo sapiens_hsa04210	0.55659635
81	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.53447594
82	Basal transcription factors_Homo sapiens_hsa03022	0.51566128
83	Glucagon signaling pathway_Homo sapiens_hsa04922	0.50743070
84	Notch signaling pathway_Homo sapiens_hsa04330	0.50487070
85	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.50235941
86	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.49722571
87	GnRH signaling pathway_Homo sapiens_hsa04912	0.48679935
88	Proteoglycans in cancer_Homo sapiens_hsa05205	0.46529012
89	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.46186174
90	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.45994587
91	RNA degradation_Homo sapiens_hsa03018	0.45131371
92	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.43658860
93	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.43227272
94	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.40706553
95	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.40423261
96	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.40035928
97	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.37997559
98	Alcoholism_Homo sapiens_hsa05034	0.37750860
99	Melanoma_Homo sapiens_hsa05218	0.37644370
100	Influenza A_Homo sapiens_hsa05164	0.36175646

SLC16A6P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »