SLC16A7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the monocarboxylate transporter family. Members in this family transport metabolites, such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked transport of monocarboxylates and has the highest affinity for pyruvate. This protein has been reported to be more highly expressed in prostate and colorectal cancer specimens when compared to control specimens. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.06296907
2L-phenylalanine catabolic process (GO:0006559)6.06296907
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.66083375
4L-phenylalanine metabolic process (GO:0006558)5.66083375
5aromatic amino acid family catabolic process (GO:0009074)5.46934255
6tryptophan catabolic process (GO:0006569)4.95641497
7indole-containing compound catabolic process (GO:0042436)4.95641497
8indolalkylamine catabolic process (GO:0046218)4.95641497
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.78956901
10tryptophan metabolic process (GO:0006568)4.65349367
11kynurenine metabolic process (GO:0070189)4.63664591
12urea cycle (GO:0000050)4.49538651
13urea metabolic process (GO:0019627)4.49538651
14bile acid biosynthetic process (GO:0006699)4.49520239
15glyoxylate metabolic process (GO:0046487)4.44609175
16high-density lipoprotein particle remodeling (GO:0034375)4.43618483
17sulfur amino acid catabolic process (GO:0000098)4.36011698
18alpha-linolenic acid metabolic process (GO:0036109)4.33533524
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.31064843
20cysteine metabolic process (GO:0006534)4.24918235
21nitrogen cycle metabolic process (GO:0071941)4.21141440
22cellular ketone body metabolic process (GO:0046950)4.13271738
23amino-acid betaine metabolic process (GO:0006577)4.09398129
24regulation of sequestering of triglyceride (GO:0010889)4.07899520
25sperm motility (GO:0030317)4.05966598
26regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.02148888
27regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.98583014
28bile acid metabolic process (GO:0008206)3.98227184
29complement activation, alternative pathway (GO:0006957)3.95058932
30peptidyl-glutamic acid carboxylation (GO:0017187)3.94570340
31protein carboxylation (GO:0018214)3.94570340
32drug catabolic process (GO:0042737)3.94254400
33aromatic amino acid family metabolic process (GO:0009072)3.91932729
34behavioral response to nicotine (GO:0035095)3.90695923
35homocysteine metabolic process (GO:0050667)3.87704412
36reverse cholesterol transport (GO:0043691)3.86819832
37tyrosine metabolic process (GO:0006570)3.85077842
38negative regulation of sterol transport (GO:0032372)3.83485187
39negative regulation of cholesterol transport (GO:0032375)3.83485187
40alpha-amino acid catabolic process (GO:1901606)3.81925867
41lysine metabolic process (GO:0006553)3.81237186
42lysine catabolic process (GO:0006554)3.81237186
43serine family amino acid catabolic process (GO:0009071)3.80640076
44regulation of fibrinolysis (GO:0051917)3.80020550
45regulation of triglyceride catabolic process (GO:0010896)3.79946673
46response to epinephrine (GO:0071871)3.79884187
47dicarboxylic acid biosynthetic process (GO:0043650)3.78745937
48glutamate metabolic process (GO:0006536)3.78589403
49negative regulation of fibrinolysis (GO:0051918)3.73523752
50plasma lipoprotein particle remodeling (GO:0034369)3.73389722
51protein-lipid complex remodeling (GO:0034368)3.73389722
52macromolecular complex remodeling (GO:0034367)3.73389722
53organic cation transport (GO:0015695)3.72460522
54cellular response to epinephrine stimulus (GO:0071872)3.71416992
55drug transmembrane transport (GO:0006855)3.69623807
56membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.68415321
57short-chain fatty acid metabolic process (GO:0046459)3.65060501
58regulation of protein activation cascade (GO:2000257)3.61254908
59fatty acid transmembrane transport (GO:1902001)3.60570918
60regulation of cholesterol esterification (GO:0010872)3.59627941
61cellular amino acid catabolic process (GO:0009063)3.59323836
62ketone body metabolic process (GO:1902224)3.59301899
63interkinetic nuclear migration (GO:0022027)3.58935363
64indolalkylamine metabolic process (GO:0006586)3.57522231
65coenzyme catabolic process (GO:0009109)3.56559085
66exogenous drug catabolic process (GO:0042738)3.55478942
67cellular modified amino acid catabolic process (GO:0042219)3.54593799
68positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.50972325
69cellular biogenic amine catabolic process (GO:0042402)3.50216439
70amine catabolic process (GO:0009310)3.50216439
71negative regulation of lipase activity (GO:0060192)3.48346841
72regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.47531818
73cAMP catabolic process (GO:0006198)3.47223649
74acylglycerol homeostasis (GO:0055090)3.42095011
75triglyceride homeostasis (GO:0070328)3.42095011
76positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.38274203
77phospholipid efflux (GO:0033700)3.37734089
78cellular glucuronidation (GO:0052695)3.37561824
79acrosome reaction (GO:0007340)3.37376909
80plasma lipoprotein particle clearance (GO:0034381)3.36476286
81bile acid and bile salt transport (GO:0015721)3.36163371
82positive regulation of fatty acid oxidation (GO:0046321)3.35521195
83regulation of complement activation (GO:0030449)3.34276269
84pyrimidine nucleobase catabolic process (GO:0006208)3.33680318
85cholesterol efflux (GO:0033344)3.33347251
86benzene-containing compound metabolic process (GO:0042537)3.30406935
87regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.23832169
88relaxation of cardiac muscle (GO:0055119)3.20300347
89detection of calcium ion (GO:0005513)3.20206863
90positive regulation of action potential (GO:0045760)3.18956058
91fusion of sperm to egg plasma membrane (GO:0007342)3.18487318
92carboxylic acid catabolic process (GO:0046395)3.16943441
93organic acid catabolic process (GO:0016054)3.16943441
94aspartate family amino acid catabolic process (GO:0009068)3.15261971
95cell wall macromolecule metabolic process (GO:0044036)3.14976835
96cell wall macromolecule catabolic process (GO:0016998)3.14976835
97carnitine metabolic process (GO:0009437)3.14949975
98cyclic nucleotide catabolic process (GO:0009214)3.14083404
99positive regulation of heart rate (GO:0010460)3.13550582
100flavonoid metabolic process (GO:0009812)3.09198435
101regulation of cell communication by electrical coupling (GO:0010649)3.08258681
102low-density lipoprotein particle remodeling (GO:0034374)3.07314297
103urate metabolic process (GO:0046415)3.07059858
104positive regulation of lipid catabolic process (GO:0050996)3.05735759
105positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.05557976
106glucuronate metabolic process (GO:0019585)3.03750042
107uronic acid metabolic process (GO:0006063)3.03750042
108regulation of sarcomere organization (GO:0060297)3.03244090
109acetyl-CoA metabolic process (GO:0006084)3.02651755
110indole-containing compound metabolic process (GO:0042430)3.01969289
111response to mercury ion (GO:0046689)3.00552416
112myofibril assembly (GO:0030239)3.00004244
113cardiac myofibril assembly (GO:0055003)2.99330269
114nucleobase catabolic process (GO:0046113)2.97533958
115cofactor catabolic process (GO:0051187)2.96139909
116ethanol oxidation (GO:0006069)2.96042560
117monocarboxylic acid catabolic process (GO:0072329)2.95585298
118fibrinolysis (GO:0042730)2.94528589
119drug transport (GO:0015893)2.93422624
120carnitine shuttle (GO:0006853)2.92195324
121multicellular organism reproduction (GO:0032504)2.92107289
122positive regulation of triglyceride lipase activity (GO:0061365)2.91877345
123positive regulation of lipoprotein lipase activity (GO:0051006)2.91877345
124fatty acid oxidation (GO:0019395)2.90677361
125drug metabolic process (GO:0017144)2.89341539
126arginine metabolic process (GO:0006525)2.89023946
127regulation of relaxation of muscle (GO:1901077)2.87496488
128neuronal action potential (GO:0019228)2.86720204
129response to caffeine (GO:0031000)2.83003013
130regulation of cardiac muscle contraction (GO:0055117)2.81403095
131sarcomere organization (GO:0045214)2.75658284
132pericardium development (GO:0060039)2.75365522
133regulation of striated muscle contraction (GO:0006942)2.74916143
134serotonin metabolic process (GO:0042428)2.74502375
135fucose catabolic process (GO:0019317)2.74070996
136L-fucose metabolic process (GO:0042354)2.74070996
137L-fucose catabolic process (GO:0042355)2.74070996
138regulation of energy homeostasis (GO:2000505)2.73569564
139positive regulation of fatty acid beta-oxidation (GO:0032000)2.73077634
140adrenergic receptor signaling pathway (GO:0071875)2.67519842
141sulfation (GO:0051923)2.65616996
142regulation of action potential (GO:0098900)2.63969376
143regulation of actin filament-based movement (GO:1903115)2.60774726
144neural tube formation (GO:0001841)2.55910215
145regulation of pigment cell differentiation (GO:0050932)2.55103301
146negative regulation of cytosolic calcium ion concentration (GO:0051481)2.54572869
147regulation of membrane repolarization (GO:0060306)2.54505048
148membrane depolarization during action potential (GO:0086010)2.51251299
149urinary tract smooth muscle contraction (GO:0014848)2.50399973
150regulation of establishment of cell polarity (GO:2000114)2.47987136
151reflex (GO:0060004)2.47596064
152cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.47009149
153positive regulation of glycolytic process (GO:0045821)2.46730109
154positive regulation of cardiac muscle cell differentiation (GO:2000727)2.46706665
155primary amino compound metabolic process (GO:1901160)2.45492283
156cellular response to ethanol (GO:0071361)2.43807317
157activated T cell proliferation (GO:0050798)2.43786540
158positive regulation of cation channel activity (GO:2001259)2.40806618
159cardiac muscle hypertrophy (GO:0003300)2.39510929
160adult heart development (GO:0007512)2.37502395
161establishment of protein localization to Golgi (GO:0072600)2.37444334
162action potential (GO:0001508)2.37295377
163cardiac muscle contraction (GO:0060048)2.35341991
164regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.33837472
165detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.30973587
166signal peptide processing (GO:0006465)2.30948678
167negative regulation of synaptic transmission, GABAergic (GO:0032229)2.29717090
168striated muscle hypertrophy (GO:0014897)2.29501513
169renal tubule morphogenesis (GO:0061333)2.27414723
170positive regulation of phosphatase activity (GO:0010922)2.27308284
171regulation of fatty acid oxidation (GO:0046320)2.27185628
172cardiovascular system development (GO:0072358)2.27104889
173regulation of lipoprotein metabolic process (GO:0050746)2.25895129
174carnitine transmembrane transport (GO:1902603)2.25232806
175regulation of establishment or maintenance of cell polarity (GO:0032878)2.25129661
176parturition (GO:0007567)2.24042556
177epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.22689291
178regulation of the force of heart contraction (GO:0002026)2.20522456
179nephron epithelium morphogenesis (GO:0072088)2.19211061
180nephron tubule morphogenesis (GO:0072078)2.19211061
181cGMP-mediated signaling (GO:0019934)2.19208358
182regulation of heart rate (GO:0002027)2.19036970
183polyol transport (GO:0015791)2.18980044
184adult feeding behavior (GO:0008343)2.18276657
185positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.18033875
186regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.18007045
187toxin metabolic process (GO:0009404)2.18004498
188regulation of calcium ion transmembrane transporter activity (GO:1901019)2.17942559
189regulation of calcium ion transmembrane transport (GO:1903169)2.17942559
190response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.17906282

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.19377729
2* RXR_22158963_ChIP-Seq_LIVER_Mouse3.81239101
3* LXR_22158963_ChIP-Seq_LIVER_Mouse3.27767340
4EGR1_23403033_ChIP-Seq_LIVER_Mouse3.25532384
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.07510225
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.82035709
7EZH2_22144423_ChIP-Seq_EOC_Human2.78780311
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.54518496
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.45688670
10* GBX2_23144817_ChIP-Seq_PC3_Human2.42186092
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21859989
12TAF15_26573619_Chip-Seq_HEK293_Human2.19266179
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.15503383
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.14367703
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.13012983
16GATA1_22025678_ChIP-Seq_K562_Human2.07282281
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.03150554
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.88946638
19SMAD_19615063_ChIP-ChIP_OVARY_Human1.83973509
20FUS_26573619_Chip-Seq_HEK293_Human1.73134823
21PCGF2_27294783_Chip-Seq_NPCs_Mouse1.72624969
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67179699
23* ER_23166858_ChIP-Seq_MCF-7_Human1.67156475
24IGF1R_20145208_ChIP-Seq_DFB_Human1.64874824
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60127303
26TP53_16413492_ChIP-PET_HCT116_Human1.59171942
27CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.58174848
28EWS_26573619_Chip-Seq_HEK293_Human1.49701153
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.49208559
30* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47331864
31* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44190885
32EP300_21415370_ChIP-Seq_HL-1_Mouse1.43462584
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.39611701
34AR_21572438_ChIP-Seq_LNCaP_Human1.38387251
35* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.37718001
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36869408
37* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36003698
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.34154435
39* PIAS1_25552417_ChIP-Seq_VCAP_Human1.32171779
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.32147962
41* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31041591
42IRF8_22096565_ChIP-ChIP_GC-B_Human1.29597846
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29425447
44NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28448607
45NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28448607
46RUNX_20019798_ChIP-Seq_JUKART_Human1.28313757
47CJUN_26792858_Chip-Seq_BT549_Human1.27154199
48P300_19829295_ChIP-Seq_ESCs_Human1.26449753
49SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.26433868
50* SMAD4_21799915_ChIP-Seq_A2780_Human1.26247887
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.26078135
52MTF2_20144788_ChIP-Seq_MESCs_Mouse1.25257044
53EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24900715
54REST_21632747_ChIP-Seq_MESCs_Mouse1.23343151
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22870808
56CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.22821065
57PRDM14_20953172_ChIP-Seq_ESCs_Human1.21943723
58DROSHA_22980978_ChIP-Seq_HELA_Human1.21385616
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21004584
60* KDM2B_26808549_Chip-Seq_REH_Human1.20195316
61* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19867554
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19639182
63ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18255626
64RXR_22108803_ChIP-Seq_LS180_Human1.18011062
65* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17629872
66TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17363713
67SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.17230056
68HTT_18923047_ChIP-ChIP_STHdh_Human1.16784744
69* FLI1_21867929_ChIP-Seq_TH2_Mouse1.16546700
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16484856
71TCF4_22108803_ChIP-Seq_LS180_Human1.15644445
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.15457224
73EZH2_27294783_Chip-Seq_ESCs_Mouse1.14522180
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.13771953
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13243083
76AR_25329375_ChIP-Seq_VCAP_Human1.12947859
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12738139
78FOXA2_19822575_ChIP-Seq_HepG2_Human1.12708736
79* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12466306
80SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.12279953
81ZNF274_21170338_ChIP-Seq_K562_Hela1.11787748
82SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11690234
83* SOX2_21211035_ChIP-Seq_LN229_Gbm1.11201972
84RUNX2_22187159_ChIP-Seq_PCA_Human1.10407548
85* ARNT_22903824_ChIP-Seq_MCF-7_Human1.10260474
86* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09235118
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08882397
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08704919
89* SMAD3_21741376_ChIP-Seq_EPCs_Human1.07652836
90IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07280556
91STAT3_18555785_Chip-Seq_ESCs_Mouse1.07178586
92* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07100884
93* VDR_22108803_ChIP-Seq_LS180_Human1.07098391
94CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06744395
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.06137726
96PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05362912
97SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05130600
98JARID2_20064375_ChIP-Seq_MESCs_Mouse1.04720664
99* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04478240
100P53_22387025_ChIP-Seq_ESCs_Mouse1.04124498
101CDX2_22108803_ChIP-Seq_LS180_Human1.03747992
102* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03130978
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.02745627
104* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.01184404
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00527676
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00527676
107BCAT_22108803_ChIP-Seq_LS180_Human1.00503843
108CBP_20019798_ChIP-Seq_JUKART_Human0.99796879
109IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99796879
110SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99579481
111* AHR_22903824_ChIP-Seq_MCF-7_Human0.99410985
112TAL1_26923725_Chip-Seq_HPCs_Mouse0.98531119
113* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98148769
114EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97629632
115RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97629632
116CMYC_18555785_Chip-Seq_ESCs_Mouse0.97537428
117EED_16625203_ChIP-ChIP_MESCs_Mouse0.96327284
118* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95062360
119E2F1_18555785_Chip-Seq_ESCs_Mouse0.94918250
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94027300
121SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94002954
122RUNX1_27457419_Chip-Seq_LIVER_Mouse0.93226737
123TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93171020
124NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92955759
125* TCF4_23295773_ChIP-Seq_U87_Human0.92900450
126OCT4_18555785_Chip-Seq_ESCs_Mouse0.92388865
127EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.92307862
128P300_18555785_Chip-Seq_ESCs_Mouse0.91810401
129EZH2_27304074_Chip-Seq_ESCs_Mouse0.90298620
130SMAD4_21741376_ChIP-Seq_EPCs_Human0.90075931
131MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90020627
132JARID2_20075857_ChIP-Seq_MESCs_Mouse0.90007786
133* CRX_20693478_ChIP-Seq_RETINA_Mouse0.89789415
134Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.89739697
135* STAT3_23295773_ChIP-Seq_U87_Human0.89542226
136STAT1_17558387_ChIP-Seq_HELA_Human0.89056895
137RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87879734
138* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.87371932

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.80622705
2MP0005360_urolithiasis6.24867736
3MP0005085_abnormal_gallbladder_physiolo5.15451043
4MP0005365_abnormal_bile_salt5.07621324
5MP0008875_abnormal_xenobiotic_pharmacok4.73049563
6MP0000569_abnormal_digit_pigmentation4.12932825
7MP0005410_abnormal_fertilization3.62265886
8MP0004215_abnormal_myocardial_fiber3.46762078
9MP0004084_abnormal_cardiac_muscle3.31171794
10MP0003252_abnormal_bile_duct3.08435482
11MP0003646_muscle_fatigue2.99854544
12MP0003195_calcinosis2.97186403
13MP0010329_abnormal_lipoprotein_level2.90316443
14MP0005332_abnormal_amino_acid2.72928981
15MP0004484_altered_response_of2.51722156
16MP0004019_abnormal_vitamin_homeostasis2.36557304
17MP0005670_abnormal_white_adipose2.18713154
18MP0003806_abnormal_nucleotide_metabolis2.14698881
19MP0001666_abnormal_nutrient_absorption2.10073931
20MP0005503_abnormal_tendon_morphology2.03706297
21MP0005083_abnormal_biliary_tract2.00861440
22MP0004036_abnormal_muscle_relaxation1.99272385
23MP0003950_abnormal_plasma_membrane1.94771203
24MP0002118_abnormal_lipid_homeostasis1.88631292
25MP0008775_abnormal_heart_ventricle1.80187417
26MP0003868_abnormal_feces_composition1.79328097
27MP0004510_myositis1.76320826
28MP0003137_abnormal_impulse_conducting1.75769290
29MP0004043_abnormal_pH_regulation1.74282227
30MP0010386_abnormal_urinary_bladder1.70593455
31MP0003191_abnormal_cellular_cholesterol1.70312826
32MP0002138_abnormal_hepatobiliary_system1.66291319
33MP0009840_abnormal_foam_cell1.61850551
34MP0005647_abnormal_sex_gland1.60245051
35MP0002876_abnormal_thyroid_physiology1.59408691
36MP0000751_myopathy1.56887816
37MP0001764_abnormal_homeostasis1.56652704
38MP0004142_abnormal_muscle_tone1.56141319
39MP0005620_abnormal_muscle_contractility1.54818064
40MP0006138_congestive_heart_failure1.52719580
41MP0000609_abnormal_liver_physiology1.51392043
42MP0004859_abnormal_synaptic_plasticity1.49100965
43MP0005451_abnormal_body_composition1.47700244
44MP0000427_abnormal_hair_cycle1.46680721
45MP0001544_abnormal_cardiovascular_syste1.46154918
46MP0005385_cardiovascular_system_phenoty1.46154918
47MP0004085_abnormal_heartbeat1.45652625
48MP0003045_fibrosis1.43284877
49MP0005584_abnormal_enzyme/coenzyme_acti1.42135803
50MP0005319_abnormal_enzyme/_coenzyme1.41803710
51MP0003959_abnormal_lean_body1.39688650
52MP0002972_abnormal_cardiac_muscle1.39505532
53MP0005636_abnormal_mineral_homeostasis1.37920799
54MP0001765_abnormal_ion_homeostasis1.37678161
55MP0003880_abnormal_central_pattern1.37591986
56MP0009643_abnormal_urine_homeostasis1.32673303
57MP0005275_abnormal_skin_tensile1.32233927
58MP0002638_abnormal_pupillary_reflex1.31878381
59MP0002332_abnormal_exercise_endurance1.26906144
60MP0003690_abnormal_glial_cell1.26485091
61MP0004924_abnormal_behavior1.26084897
62MP0005386_behavior/neurological_phenoty1.26084897
63MP0000604_amyloidosis1.26021982
64MP0005535_abnormal_body_temperature1.20406117
65MP0003698_abnormal_male_reproductive1.19442757
66MP0003329_amyloid_beta_deposits1.17853643
67MP0003828_pulmonary_edema1.17679118
68MP0005174_abnormal_tail_pigmentation1.17414289
69MP0008961_abnormal_basal_metabolism1.16918244
70MP0010368_abnormal_lymphatic_system1.16515798
71MP0003136_yellow_coat_color1.16000255
72MP0003724_increased_susceptibility_to1.15423955
73MP0005171_absent_coat_pigmentation1.13985908
74MP0009697_abnormal_copulation1.12520679
75MP0001879_abnormal_lymphatic_vessel1.11697883
76MP0001756_abnormal_urination1.10762374
77MP0009745_abnormal_behavioral_response1.10023332
78MP0002736_abnormal_nociception_after1.08833590
79MP0004145_abnormal_muscle_electrophysio1.06808589
80MP0005595_abnormal_vascular_smooth1.05568393
81MP0004130_abnormal_muscle_cell1.04737921
82MP0001968_abnormal_touch/_nociception1.03920143
83MP0009764_decreased_sensitivity_to0.98953554
84MP0009115_abnormal_fat_cell0.98689838
85MP0000749_muscle_degeneration0.98391722
86MP0003635_abnormal_synaptic_transmissio0.98334266
87MP0009046_muscle_twitch0.98324948
88MP0002063_abnormal_learning/memory/cond0.94929360
89MP0005253_abnormal_eye_physiology0.93581751
90MP0001486_abnormal_startle_reflex0.93393028
91MP0001440_abnormal_grooming_behavior0.93023597
92MP0002572_abnormal_emotion/affect_behav0.91476739
93MP0002064_seizures0.91202320
94MP0002933_joint_inflammation0.90683272
95MP0002735_abnormal_chemical_nociception0.89659426
96MP0001501_abnormal_sleep_pattern0.89221259
97MP0001986_abnormal_taste_sensitivity0.89044726
98MP0001958_emphysema0.88721019
99MP0001485_abnormal_pinna_reflex0.88583496
100MP0005266_abnormal_metabolism0.88110682
101MP0003279_aneurysm0.87827917
102MP0002971_abnormal_brown_adipose0.86725414
103MP0002822_catalepsy0.85695217
104MP0001984_abnormal_olfaction0.85287008
105MP0005187_abnormal_penis_morphology0.85235025
106MP0001661_extended_life_span0.85190805
107MP0004270_analgesia0.83218253
108MP0002168_other_aberrant_phenotype0.83197317
109MP0008004_abnormal_stomach_pH0.82856019
110MP0009780_abnormal_chondrocyte_physiolo0.82584399
111MP0005334_abnormal_fat_pad0.82569987
112MP0005330_cardiomyopathy0.82208185
113MP0003763_abnormal_thymus_physiology0.81071726
114MP0003011_delayed_dark_adaptation0.79654705
115MP0004885_abnormal_endolymph0.78865072
116MP0008874_decreased_physiological_sensi0.78548798
117MP0003633_abnormal_nervous_system0.78471253
118MP0002106_abnormal_muscle_physiology0.78262358
119MP0005165_increased_susceptibility_to0.78252366
120MP0002254_reproductive_system_inflammat0.77480620
121MP0002009_preneoplasia0.76175947
122MP0009642_abnormal_blood_homeostasis0.75647866
123MP0009765_abnormal_xenobiotic_induced0.75210449
124MP0001929_abnormal_gametogenesis0.74615516
125MP0006072_abnormal_retinal_apoptosis0.73877971
126MP0005164_abnormal_response_to0.73124985
127MP0005369_muscle_phenotype0.73044517
128MP0003656_abnormal_erythrocyte_physiolo0.72715254
129MP0002078_abnormal_glucose_homeostasis0.72559401
130MP0002136_abnormal_kidney_physiology0.72273646
131MP0005646_abnormal_pituitary_gland0.72188684
132MP0008872_abnormal_physiological_respon0.71434667
133MP0000372_irregular_coat_pigmentation0.71139675
134MP0002108_abnormal_muscle_morphology0.69275806
135MP0002909_abnormal_adrenal_gland0.68862379
136MP0004883_abnormal_blood_vessel0.67829832
137MP0002102_abnormal_ear_morphology0.67782610
138MP0005084_abnormal_gallbladder_morpholo0.67696828
139MP0003879_abnormal_hair_cell0.67462841
140MP0000230_abnormal_systemic_arterial0.67364090
141MP0009384_cardiac_valve_regurgitation0.65932275
142MP0001664_abnormal_digestion0.65922633
143MP0002272_abnormal_nervous_system0.65901227
144MP0005666_abnormal_adipose_tissue0.65778969
145MP0002067_abnormal_sensory_capabilities0.65373785
146MP0002127_abnormal_cardiovascular_syste0.63461487
147MP0002161_abnormal_fertility/fecundity0.62448926
148MP0000538_abnormal_urinary_bladder0.59844777
149MP0000598_abnormal_liver_morphology0.59671793
150MP0003075_altered_response_to0.59553154
151MP0002069_abnormal_eating/drinking_beha0.57529448
152MP0003631_nervous_system_phenotype0.57117937
153MP0006276_abnormal_autonomic_nervous0.56598931
154MP0009763_increased_sensitivity_to0.56520392
155MP0003186_abnormal_redox_activity0.56474268
156MP0002557_abnormal_social/conspecific_i0.56344519
157MP0003953_abnormal_hormone_level0.55753200
158MP0005551_abnormal_eye_electrophysiolog0.54573467
159MP0005448_abnormal_energy_balance0.54347546
160MP0008469_abnormal_protein_level0.52927986
161MP0004742_abnormal_vestibular_system0.52837876
162MP0003638_abnormal_response/metabolism_0.52316606
163MP0002734_abnormal_mechanical_nocicepti0.51332127
164MP0000920_abnormal_myelination0.50278247
165MP0002837_dystrophic_cardiac_calcinosis0.49603869
166MP0002928_abnormal_bile_duct0.49340670

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.41394877
2Deep venous thrombosis (HP:0002625)5.38122725
3Prolonged partial thromboplastin time (HP:0003645)5.11189015
4Intrahepatic cholestasis (HP:0001406)4.99792363
5Absent/shortened dynein arms (HP:0200106)4.77420252
6Dynein arm defect of respiratory motile cilia (HP:0012255)4.77420252
7Xanthomatosis (HP:0000991)4.53250666
8Abnormality of monocarboxylic acid metabolism (HP:0010996)4.48904765
9Sudden death (HP:0001699)4.31499921
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.27309353
11Hyperlipoproteinemia (HP:0010980)4.19422113
12Atrial fibrillation (HP:0005110)4.16914114
13Hypobetalipoproteinemia (HP:0003563)4.11868897
14Bundle branch block (HP:0011710)4.08613581
15Complement deficiency (HP:0004431)4.08007823
16Joint hemorrhage (HP:0005261)3.97638445
17Ketosis (HP:0001946)3.80382187
18Epidermoid cyst (HP:0200040)3.80322576
19Primary atrial arrhythmia (HP:0001692)3.72353226
20Pancreatic cysts (HP:0001737)3.70683261
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.63840222
22Abnormality of aspartate family amino acid metabolism (HP:0010899)3.54688004
23Hyperammonemia (HP:0001987)3.53306300
24Syncope (HP:0001279)3.50167197
25Supraventricular tachycardia (HP:0004755)3.43528104
26Hyperglycinuria (HP:0003108)3.43298372
27Hyperglycinemia (HP:0002154)3.38354992
28Supraventricular arrhythmia (HP:0005115)3.34439342
29Hyperventilation (HP:0002883)3.30697996
30Abnormality of sulfur amino acid metabolism (HP:0004339)3.29999864
31Hypolipoproteinemia (HP:0010981)3.29516835
32Abnormality of methionine metabolism (HP:0010901)3.29350703
33Conjugated hyperbilirubinemia (HP:0002908)3.28476951
34Abnormality of serine family amino acid metabolism (HP:0010894)3.28128420
35Abnormality of glycine metabolism (HP:0010895)3.28128420
36Hypoalphalipoproteinemia (HP:0003233)3.19292840
37Congenital stationary night blindness (HP:0007642)3.11142970
38Abnormal respiratory motile cilium physiology (HP:0012261)3.10731861
39Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.10628694
40Hypercholesterolemia (HP:0003124)3.06719693
41Abnormality of the common coagulation pathway (HP:0010990)3.05759548
42Pancreatic fibrosis (HP:0100732)3.00388744
43Alkalosis (HP:0001948)3.00329102
44Genetic anticipation (HP:0003743)2.97550326
45Decreased circulating renin level (HP:0003351)2.95596474
46Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.94083637
47Abnormality of alanine metabolism (HP:0010916)2.94083637
48Hyperalaninemia (HP:0003348)2.94083637
49Gout (HP:0001997)2.93706064
50Tubular atrophy (HP:0000092)2.91966290
51Fat malabsorption (HP:0002630)2.90024013
52Congenital, generalized hypertrichosis (HP:0004540)2.89584072
53Abnormal respiratory epithelium morphology (HP:0012253)2.89493144
54Abnormal respiratory motile cilium morphology (HP:0005938)2.89493144
55Hypokalemic alkalosis (HP:0001949)2.88498254
56True hermaphroditism (HP:0010459)2.84918268
57Abnormality of complement system (HP:0005339)2.83162742
58Abnormality of fatty-acid metabolism (HP:0004359)2.82534172
59Vascular calcification (HP:0004934)2.81939250
60Congenital sensorineural hearing impairment (HP:0008527)2.80632595
61Progressive cerebellar ataxia (HP:0002073)2.73931473
62Abnormality of midbrain morphology (HP:0002418)2.73057750
63Molar tooth sign on MRI (HP:0002419)2.73057750
64Metabolic alkalosis (HP:0200114)2.69726081
65Abnormality of purine metabolism (HP:0004352)2.68324128
66Abnormality of renin-angiotensin system (HP:0000847)2.67648170
67Ketoacidosis (HP:0001993)2.67430225
68Abnormal ciliary motility (HP:0012262)2.66469606
69Abnormality of the intrinsic pathway (HP:0010989)2.64328150
70Lipoatrophy (HP:0100578)2.64102162
71Prolonged QT interval (HP:0001657)2.63041969
72Abnormality of nucleobase metabolism (HP:0010932)2.60497408
73Papilledema (HP:0001085)2.59993566
74Abnormal urine output (HP:0012590)2.59723991
75Increased circulating renin level (HP:0000848)2.59402074
76Abnormality of the renal medulla (HP:0100957)2.58805056
77Hyporeflexia of lower limbs (HP:0002600)2.56892820
78Ventricular tachycardia (HP:0004756)2.56833304
79Delayed CNS myelination (HP:0002188)2.56564224
80Left ventricular hypertrophy (HP:0001712)2.56407187
81Gaze-evoked nystagmus (HP:0000640)2.52669813
82Abnormality of renal excretion (HP:0011036)2.51741998
83Clumsiness (HP:0002312)2.51564585
84Glomerulonephritis (HP:0000099)2.50732566
85Heart block (HP:0012722)2.49827428
86Hyperaldosteronism (HP:0000859)2.49634874
87Hypothermia (HP:0002045)2.48166474
88Hyperactive renin-angiotensin system (HP:0000841)2.48096484
89Spontaneous abortion (HP:0005268)2.45529625
90Generalized hypopigmentation of hair (HP:0011358)2.45252481
91Abnormality of pyrimidine metabolism (HP:0004353)2.44843969
92Metabolic acidosis (HP:0001942)2.43035992
93Abnormality of chloride homeostasis (HP:0011422)2.42578417
94Hypomagnesemia (HP:0002917)2.42316167
95Attenuation of retinal blood vessels (HP:0007843)2.42028293
96Cardiovascular calcification (HP:0011915)2.41860262
97Neurofibrillary tangles (HP:0002185)2.39771264
98Status epilepticus (HP:0002133)2.38852220
99Abnormality of serum amino acid levels (HP:0003112)2.38828357
100Fair hair (HP:0002286)2.35327932
101Inability to walk (HP:0002540)2.33897268
102Polyuria (HP:0000103)2.33305924
103Calf muscle hypertrophy (HP:0008981)2.32800994
104Protruding tongue (HP:0010808)2.31670156
105Nephronophthisis (HP:0000090)2.31162405
106Facial diplegia (HP:0001349)2.30529116
107Enlarged kidneys (HP:0000105)2.30478590
108Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.29030957
109Prominent supraorbital ridges (HP:0000336)2.27521414
110Systemic lupus erythematosus (HP:0002725)2.26706711
111Ventricular fibrillation (HP:0001663)2.26672826
112Large for gestational age (HP:0001520)2.25563982
113Abnormal drinking behavior (HP:0030082)2.23507276
114Polydipsia (HP:0001959)2.23507276
115Chronic hepatic failure (HP:0100626)2.22959753
116Abnormality of the calf musculature (HP:0001430)2.22885266
117Abnormal gallbladder physiology (HP:0012438)2.22680734
118Cholecystitis (HP:0001082)2.22680734
119Hyperbilirubinemia (HP:0002904)2.22183004
120Abnormality of the renal cortex (HP:0011035)2.21607604
121Cystic liver disease (HP:0006706)2.21166340
122Rhinitis (HP:0012384)2.20915262
123Hyperuricemia (HP:0002149)2.20837570
124Increased purine levels (HP:0004368)2.20837570
125Abnormal EKG (HP:0003115)2.20709838
126Infertility (HP:0000789)2.19299760
127Asymmetric septal hypertrophy (HP:0001670)2.18122085
128Febrile seizures (HP:0002373)2.15806642
129Type II lissencephaly (HP:0007260)2.15390555
130Steatorrhea (HP:0002570)2.15303994
131Furrowed tongue (HP:0000221)2.15112487
132Chorioretinal atrophy (HP:0000533)2.14351149
133Hemorrhage of the eye (HP:0011885)2.14285086
134Tubulointerstitial nephritis (HP:0001970)2.13761922
135Hypophosphatemic rickets (HP:0004912)2.13542165
136Hepatocellular carcinoma (HP:0001402)2.13172566
137Chronic bronchitis (HP:0004469)2.12046333
138Abnormal atrioventricular conduction (HP:0005150)2.11791526
139Abnormality of T cell number (HP:0011839)2.08894842
140Renal cortical cysts (HP:0000803)2.08604851
141Renal salt wasting (HP:0000127)2.07271319
142Sensorimotor neuropathy (HP:0007141)2.07025819
143Tubulointerstitial abnormality (HP:0001969)2.06736150
144Widely spaced teeth (HP:0000687)2.06287779
145Muscle hypertrophy of the lower extremities (HP:0008968)2.04779176
146Proximal tubulopathy (HP:0000114)2.04442187
147Cerebral inclusion bodies (HP:0100314)2.04027729
148Atrioventricular block (HP:0001678)2.02936030
149Hypoglycemic coma (HP:0001325)2.01412440
150Stomach cancer (HP:0012126)2.00737857
151Abnormality of secondary sexual hair (HP:0009888)1.99206394
152Abnormality of the axillary hair (HP:0100134)1.99206394
153Hypoplastic ischia (HP:0003175)1.98068241
154Lethargy (HP:0001254)1.97726537
155Ventricular arrhythmia (HP:0004308)1.97572151
156Myocardial infarction (HP:0001658)1.96963376
157Pancreatitis (HP:0001733)1.95118913
158Increased corneal curvature (HP:0100692)1.93665621
159Keratoconus (HP:0000563)1.93665621
160Irritability (HP:0000737)1.93097464
161Focal motor seizures (HP:0011153)1.93070934
162Palpitations (HP:0001962)1.93062791
163Metaphyseal dysplasia (HP:0100255)1.92653334
164Amyloidosis (HP:0011034)1.92251191
165Hypokalemia (HP:0002900)1.92123484
166Acanthocytosis (HP:0001927)1.91074239
167Tubulointerstitial fibrosis (HP:0005576)1.90801158
168T lymphocytopenia (HP:0005403)1.90792323
169Rickets (HP:0002748)1.89763701
170Broad ribs (HP:0000885)1.88651608
171Abnormality of potassium homeostasis (HP:0011042)1.87261432
172Malnutrition (HP:0004395)1.87074237
173Absent speech (HP:0001344)1.86977296
174Progressive inability to walk (HP:0002505)1.86407508
175Neonatal onset (HP:0003623)1.86075086
176Medial flaring of the eyebrow (HP:0010747)1.85125327
177Generalized aminoaciduria (HP:0002909)1.83981040
178Pigmentary retinal degeneration (HP:0001146)1.82756198
179Hypoproteinemia (HP:0003075)1.79325473
180Broad-based gait (HP:0002136)1.78532492
181Abnormality of the ischium (HP:0003174)1.77821051
182Abnormality of the left ventricular outflow tract (HP:0011103)1.75009175
183Subaortic stenosis (HP:0001682)1.75009175

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK33.77296517
2PDK43.77296517
3OXSR13.45075702
4STK393.32450150
5PDK23.24094824
6WNK43.21221198
7BCKDK2.98962057
8EPHA42.93193402
9WNK32.50717058
10ACVR1B2.31927580
11CASK2.23995427
12TXK2.14898810
13DAPK22.14451878
14ADRBK22.12514761
15BMPR1B2.11030876
16NTRK32.05447360
17SIK12.00661456
18INSRR1.96080898
19OBSCN1.95568060
20MARK11.95030947
21FRK1.93932673
22TRPM71.91267330
23AKT31.82297244
24PAK31.76113917
25MST1R1.72537557
26MAP2K41.67544671
27TAOK31.58020060
28NEK91.50436874
29GRK71.48345581
30PTK2B1.43895604
31ADRBK11.43891259
32MAP2K71.43802712
33CAMK1G1.41790098
34ICK1.38832030
35NLK1.36582190
36MAP3K41.36160130
37STK381.35567991
38PRKD31.34670564
39TGFBR11.17017307
40TEC1.16031478
41TNIK1.14728229
42SGK2231.12836633
43SGK4941.12836633
44ITK1.09800310
45SGK21.09255195
46TIE11.09089029
47RIPK41.06358250
48TGFBR21.01983567
49PINK11.00315055
50LATS10.99214901
51PKN10.98209337
52PDK10.97298992
53SIK20.95874608
54MINK10.91640650
55KIT0.91013584
56TTN0.90277338
57CAMK1D0.88893886
58PRKCG0.88040736
59PDPK10.87484073
60ERN10.87264246
61TLK10.87171944
62MUSK0.84538900
63JAK10.84497304
64SYK0.83257216
65BRSK20.83075678
66WNK10.83052527
67SGK30.81918378
68MAP4K20.81910599
69FGFR20.80319263
70MAPK120.78776686
71PRKCZ0.76539429
72CAMKK10.76492067
73FGFR40.75663464
74ERBB40.75619053
75PNCK0.75101126
76CAMK2A0.73794919
77NTRK20.71906386
78PIK3CG0.68892522
79MAPK150.67816626
80NUAK10.67330191
81MAPKAPK30.67089238
82TESK10.66134592
83EPHA30.65544821
84DMPK0.63731487
85STK38L0.63474766
86BLK0.62738971
87DAPK10.62417645
88MAP2K60.61566434
89NEK60.61350333
90PRKAA20.61002377
91PDGFRB0.60842090
92MELK0.60784355
93CAMK40.60078102
94SGK10.58480770
95MAP3K20.58017218
96PRKCQ0.57818607
97ZAK0.56795001
98CSNK1G20.56638358
99TNK20.56443913
100MAP3K70.56369803
101PRKACA0.55322374
102CAMK10.55221334
103MARK20.54207004
104IRAK20.53361828
105PAK60.53113925
106CDK50.52530509
107IRAK10.52494155
108MAPKAPK50.52117727
109STK240.51438521
110MAPK70.51376368
111MAPK130.50585563
112MAP3K60.49981607
113GRK10.49625560
114PRKAA10.48890098
115MAP4K10.48747807
116STK160.48704605
117CAMK2D0.48335110
118PRKCH0.47318410
119CAMK2G0.46635677
120RPS6KA60.46117867
121MAP3K90.45188150
122FER0.45150757
123LCK0.44250437
124PRKACG0.44091704
125PIK3CA0.43831738
126MAP2K10.43152794
127IKBKB0.43141796
128STK30.42266122
129PRKD10.42052024
130GRK50.41802587
131CAMK2B0.41563308
132BMPR20.40956111
133MAPK40.40632065
134BTK0.40377786
135NTRK10.39761607
136PRKCE0.39681168
137ERBB30.39116471
138CCNB10.38733034
139PLK20.36713149
140CAMKK20.35718923
141PRKCA0.35588542
142PRKG10.35449058
143STK110.35060543
144MYLK0.33666479
145FES0.32963489
146FYN0.32518465
147ABL20.31163693
148MET0.30787005

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.57764721
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.03146439
3Nitrogen metabolism_Homo sapiens_hsa009102.88711772
4Arginine biosynthesis_Homo sapiens_hsa002202.81337039
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.75675825
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.50018687
7Propanoate metabolism_Homo sapiens_hsa006402.37901784
8Fatty acid degradation_Homo sapiens_hsa000712.35070320
9Tryptophan metabolism_Homo sapiens_hsa003802.32204410
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.30522587
11Butanoate metabolism_Homo sapiens_hsa006502.22970773
12Complement and coagulation cascades_Homo sapiens_hsa046102.19911731
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.16688549
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.10597292
15Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.08715862
16Dilated cardiomyopathy_Homo sapiens_hsa054142.00869533
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.00866582
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94604241
19PPAR signaling pathway_Homo sapiens_hsa033201.92969973
20Peroxisome_Homo sapiens_hsa041461.91651912
21Fatty acid metabolism_Homo sapiens_hsa012121.88487278
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.87732200
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.86437459
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.82341967
25Ovarian steroidogenesis_Homo sapiens_hsa049131.75500518
26Phototransduction_Homo sapiens_hsa047441.74937169
27Cardiac muscle contraction_Homo sapiens_hsa042601.74849862
28Chemical carcinogenesis_Homo sapiens_hsa052041.74709918
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.73322092
30Pyruvate metabolism_Homo sapiens_hsa006201.70486470
31Histidine metabolism_Homo sapiens_hsa003401.69808906
32Sulfur metabolism_Homo sapiens_hsa009201.67877894
33beta-Alanine metabolism_Homo sapiens_hsa004101.63344336
34Bile secretion_Homo sapiens_hsa049761.61782786
35Vascular smooth muscle contraction_Homo sapiens_hsa042701.59218047
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.56109641
37Staphylococcus aureus infection_Homo sapiens_hsa051501.51555490
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.51476712
39Calcium signaling pathway_Homo sapiens_hsa040201.48109450
40Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.45874690
41Retinol metabolism_Homo sapiens_hsa008301.45360300
42Dorso-ventral axis formation_Homo sapiens_hsa043201.42392205
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.37190856
44ABC transporters_Homo sapiens_hsa020101.32749234
45Pancreatic secretion_Homo sapiens_hsa049721.31442823
46Fatty acid elongation_Homo sapiens_hsa000621.29574243
47Circadian rhythm_Homo sapiens_hsa047101.26264837
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.24713225
49Selenocompound metabolism_Homo sapiens_hsa004501.24389493
50Phenylalanine metabolism_Homo sapiens_hsa003601.22968341
51Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.21017572
52Fatty acid biosynthesis_Homo sapiens_hsa000611.18050365
53Caffeine metabolism_Homo sapiens_hsa002321.15798243
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.11910209
55Olfactory transduction_Homo sapiens_hsa047401.11310817
56Serotonergic synapse_Homo sapiens_hsa047261.10658449
57cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10433979
58Glycerolipid metabolism_Homo sapiens_hsa005611.08591604
59cAMP signaling pathway_Homo sapiens_hsa040241.08560113
60Oxytocin signaling pathway_Homo sapiens_hsa049211.08131665
61Starch and sucrose metabolism_Homo sapiens_hsa005001.05894198
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04474410
63Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03492994
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03080536
65Tyrosine metabolism_Homo sapiens_hsa003501.02523560
66Drug metabolism - other enzymes_Homo sapiens_hsa009831.01132681
67Steroid biosynthesis_Homo sapiens_hsa001000.98926634
68Fat digestion and absorption_Homo sapiens_hsa049750.98658441
69Cholinergic synapse_Homo sapiens_hsa047250.96859828
70Vitamin digestion and absorption_Homo sapiens_hsa049770.96515740
71Vitamin B6 metabolism_Homo sapiens_hsa007500.95132805
72ECM-receptor interaction_Homo sapiens_hsa045120.91613482
73Primary immunodeficiency_Homo sapiens_hsa053400.88975511
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.88959380
75Platelet activation_Homo sapiens_hsa046110.85105128
76Nicotine addiction_Homo sapiens_hsa050330.83811081
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82585950
78Arachidonic acid metabolism_Homo sapiens_hsa005900.81768784
79Carbon metabolism_Homo sapiens_hsa012000.80275534
80Arginine and proline metabolism_Homo sapiens_hsa003300.79897282
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78434505
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.78029932
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78007409
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77813066
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74452803
86Collecting duct acid secretion_Homo sapiens_hsa049660.71930296
87Graft-versus-host disease_Homo sapiens_hsa053320.70393273
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68256624
89Biosynthesis of amino acids_Homo sapiens_hsa012300.67678545
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66973597
91T cell receptor signaling pathway_Homo sapiens_hsa046600.66707981
92Lysine degradation_Homo sapiens_hsa003100.65680081
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64707765
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.63197361
95Dopaminergic synapse_Homo sapiens_hsa047280.58526293
96Hematopoietic cell lineage_Homo sapiens_hsa046400.58336795
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57667448
98Protein digestion and absorption_Homo sapiens_hsa049740.54772174
99Oxidative phosphorylation_Homo sapiens_hsa001900.53822582
100Autoimmune thyroid disease_Homo sapiens_hsa053200.53383313
101FoxO signaling pathway_Homo sapiens_hsa040680.52897551
102MAPK signaling pathway_Homo sapiens_hsa040100.52039041
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51701842
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51378286
105Maturity onset diabetes of the young_Homo sapiens_hsa049500.50697728
106Linoleic acid metabolism_Homo sapiens_hsa005910.50374924
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49793398
108Ras signaling pathway_Homo sapiens_hsa040140.47373741
109Glucagon signaling pathway_Homo sapiens_hsa049220.46820306
110Glutathione metabolism_Homo sapiens_hsa004800.46244812
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45716881
112Long-term depression_Homo sapiens_hsa047300.45580447
113Glutamatergic synapse_Homo sapiens_hsa047240.45486624
114Synaptic vesicle cycle_Homo sapiens_hsa047210.44769608
115Alzheimers disease_Homo sapiens_hsa050100.44723655
116Parkinsons disease_Homo sapiens_hsa050120.44471523
117Allograft rejection_Homo sapiens_hsa053300.42626178
118Metabolic pathways_Homo sapiens_hsa011000.41659106
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.38965176
120Salivary secretion_Homo sapiens_hsa049700.38217546
121GABAergic synapse_Homo sapiens_hsa047270.38103909
122Renin secretion_Homo sapiens_hsa049240.37380173
123Amphetamine addiction_Homo sapiens_hsa050310.37328364
124Folate biosynthesis_Homo sapiens_hsa007900.34520252
125Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.33759907
126Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33485096
127Mineral absorption_Homo sapiens_hsa049780.28323494
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.27105289
129Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25575389
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.25552870
131Circadian entrainment_Homo sapiens_hsa047130.25525812
132Sulfur relay system_Homo sapiens_hsa041220.24050923
133Morphine addiction_Homo sapiens_hsa050320.23999683
134Taste transduction_Homo sapiens_hsa047420.23982941
135Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.23875007
136Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.22833367
137Pentose phosphate pathway_Homo sapiens_hsa000300.22204478
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.21857689
139Fructose and mannose metabolism_Homo sapiens_hsa000510.21523083
140Gastric acid secretion_Homo sapiens_hsa049710.20572939
141Long-term potentiation_Homo sapiens_hsa047200.19183659
142Thyroid hormone synthesis_Homo sapiens_hsa049180.19037218
143Ether lipid metabolism_Homo sapiens_hsa005650.18440893
144Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17887029
145Insulin secretion_Homo sapiens_hsa049110.16997697
146Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.16501237
147Insulin resistance_Homo sapiens_hsa049310.14975965
148Cocaine addiction_Homo sapiens_hsa050300.12423121

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