SLC16A8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes (Yoon et al., 1999 [PubMed 10493836]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanin metabolic process (GO:0006582)9.71538273
2secondary metabolite biosynthetic process (GO:0044550)9.10859782
3retinal metabolic process (GO:0042574)8.53534844
4protein-chromophore linkage (GO:0018298)8.35771217
5cellular response to electrical stimulus (GO:0071257)7.71086862
6detection of light stimulus involved in sensory perception (GO:0050962)7.43735803
7detection of light stimulus involved in visual perception (GO:0050908)7.43735803
8retinol metabolic process (GO:0042572)6.81852905
9fat-soluble vitamin metabolic process (GO:0006775)5.71764185
10planar cell polarity pathway involved in neural tube closure (GO:0090179)5.24223978
11tyrosine metabolic process (GO:0006570)5.09500611
12positive regulation of protein homooligomerization (GO:0032464)5.07191713
13convergent extension (GO:0060026)4.84380548
14endothelial cell chemotaxis (GO:0035767)4.84350194
15positive regulation of guanylate cyclase activity (GO:0031284)4.76470934
16response to pheromone (GO:0019236)4.73125462
17regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.72670835
18negative regulation of cytosolic calcium ion concentration (GO:0051481)4.47890374
19camera-type eye morphogenesis (GO:0048593)4.39598403
20regulation of hippo signaling (GO:0035330)4.27908264
21regulation of skeletal muscle contraction (GO:0014819)4.26502031
22regulation of guanylate cyclase activity (GO:0031282)4.25170384
23gonadal mesoderm development (GO:0007506)4.21365796
24retinal rod cell development (GO:0046548)4.12094200
25negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.07706710
26quaternary ammonium group transport (GO:0015697)4.00862536
27protein import into peroxisome matrix (GO:0016558)3.82430306
28primary alcohol metabolic process (GO:0034308)3.81903436
29regulation of rhodopsin mediated signaling pathway (GO:0022400)3.81274776
30adherens junction assembly (GO:0034333)3.75943532
31bicarbonate transport (GO:0015701)3.72812808
32ruffle organization (GO:0031529)3.70367944
33negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.69289531
34regulation of histone H3-K27 methylation (GO:0061085)3.67739597
35secondary metabolic process (GO:0019748)3.66853445
36negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.58809955
37histone H4-K16 acetylation (GO:0043984)3.56855936
38cellular component maintenance (GO:0043954)3.56761042
39type B pancreatic cell proliferation (GO:0044342)3.55146708
40determination of adult lifespan (GO:0008340)3.55101376
41phototransduction (GO:0007602)3.52604702
42sodium ion export (GO:0071436)3.51222444
43detection of light stimulus (GO:0009583)3.49857047
44rhodopsin mediated signaling pathway (GO:0016056)3.41784010
45ribosomal large subunit biogenesis (GO:0042273)3.39986647
46mitochondrion distribution (GO:0048311)3.36375303
47phenol-containing compound biosynthetic process (GO:0046189)3.35820272
48branching involved in salivary gland morphogenesis (GO:0060445)3.31174999
49peptidyl-lysine dimethylation (GO:0018027)3.30650823
50regulation of cytokine production involved in inflammatory response (GO:1900015)3.29452579
51retinoic acid metabolic process (GO:0042573)3.26383353
52ketone body metabolic process (GO:1902224)3.25111345
53semaphorin-plexin signaling pathway (GO:0071526)3.23555550
54positive regulation of histone deacetylation (GO:0031065)3.20894669
55positive regulation by host of viral transcription (GO:0043923)3.19152151
56regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.17817595
57Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.17004460
58melanocyte differentiation (GO:0030318)3.15058854
59regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.14410913
60positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.13163981
61focal adhesion assembly (GO:0048041)3.12996111
62cell-substrate adherens junction assembly (GO:0007045)3.12996111
63regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.11906084
64vascular endothelial growth factor signaling pathway (GO:0038084)3.11747317
65positive regulation of protein deacetylation (GO:0090312)3.08730717
66regulation of synapse maturation (GO:0090128)3.08282089
67phototransduction, visible light (GO:0007603)3.06193498
68skeletal muscle adaptation (GO:0043501)3.04781427
69G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.01567582
70mitochondrial DNA metabolic process (GO:0032042)3.00221911
71cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.00021603
72vitamin A metabolic process (GO:0006776)23.2786721
73DNA methylation involved in gamete generation (GO:0043046)2.97394953
74detection of visible light (GO:0009584)2.96651924
75keratan sulfate catabolic process (GO:0042340)2.95701792
76visual perception (GO:0007601)2.95367623
77sensory perception of light stimulus (GO:0050953)2.94955232
78regulation of establishment of planar polarity (GO:0090175)2.94633831
79negative regulation of granulocyte differentiation (GO:0030853)2.94290636
80positive regulation of cGMP biosynthetic process (GO:0030828)2.94226186
81regulation of protein homooligomerization (GO:0032462)2.94173693
82potassium ion import (GO:0010107)2.93967321
83cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.92075074
84histone H3 deacetylation (GO:0070932)2.91181329
85retinoid metabolic process (GO:0001523)2.90569529
86protein targeting to plasma membrane (GO:0072661)2.89414787
87regulation of retinoic acid receptor signaling pathway (GO:0048385)2.87430841
88negative regulation of catenin import into nucleus (GO:0035414)2.87261069
89regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.86815553
90cytoskeletal anchoring at plasma membrane (GO:0007016)2.85022502
91vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.84246771
92apical protein localization (GO:0045176)2.81477337
93regulation of cGMP metabolic process (GO:0030823)2.81470561
94cell proliferation in forebrain (GO:0021846)2.79711630
95positive regulation of cGMP metabolic process (GO:0030825)2.79491926
96sialylation (GO:0097503)2.78223587
97response to electrical stimulus (GO:0051602)2.77680801
98regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.76770255
99synaptic vesicle maturation (GO:0016188)2.74557959
100retinal cone cell development (GO:0046549)2.73414478
101cell communication by electrical coupling (GO:0010644)2.72305481
102interleukin-6-mediated signaling pathway (GO:0070102)2.71798666
103regulation of cGMP biosynthetic process (GO:0030826)2.71417668
104pigment cell differentiation (GO:0050931)2.71161135
105positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.68598267
106positive regulation of T cell apoptotic process (GO:0070234)2.68445223
107neuroblast proliferation (GO:0007405)2.65603937
108diterpenoid metabolic process (GO:0016101)2.65139637
109sarcomere organization (GO:0045214)2.65068446
110positive regulation of protein kinase C signaling (GO:0090037)2.65044412
111ear development (GO:0043583)2.64191862
112tooth mineralization (GO:0034505)2.63423097
113detection of external stimulus (GO:0009581)2.63422257
114cornea development in camera-type eye (GO:0061303)2.63242963
115negative regulation of macroautophagy (GO:0016242)2.62466196
116epithelial cell fate commitment (GO:0072148)2.62352137
117cochlea morphogenesis (GO:0090103)2.61394187
118regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.59977875
119regulation of fatty acid beta-oxidation (GO:0031998)2.56398139
120negative regulation of JUN kinase activity (GO:0043508)2.56066259
121regulation of short-term neuronal synaptic plasticity (GO:0048172)2.55475631
122detection of abiotic stimulus (GO:0009582)2.55093857
123carnitine shuttle (GO:0006853)2.54217674
124regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.52134803
125histone H4-K8 acetylation (GO:0043982)2.51048895
126histone H4-K5 acetylation (GO:0043981)2.51048895
127cellular potassium ion homeostasis (GO:0030007)2.50761352
128negative regulation of myotube differentiation (GO:0010832)2.49433175
129piRNA metabolic process (GO:0034587)2.49346720
130positive regulation of neuroblast proliferation (GO:0002052)2.49200683
131non-canonical Wnt signaling pathway (GO:0035567)2.48880103
132potassium ion homeostasis (GO:0055075)2.48721513
133pinocytosis (GO:0006907)2.47301256
134cellular aldehyde metabolic process (GO:0006081)2.47278373
135epithelial cell-cell adhesion (GO:0090136)2.47153257
136labyrinthine layer development (GO:0060711)2.47050368
137neurotransmitter-gated ion channel clustering (GO:0072578)2.46901636
138regulation of gene silencing by RNA (GO:0060966)2.45108375
139regulation of posttranscriptional gene silencing (GO:0060147)2.45108375
140regulation of gene silencing by miRNA (GO:0060964)2.45108375
141peroxisomal transport (GO:0043574)2.44287604
142negative regulation of potassium ion transmembrane transport (GO:1901380)2.43581886
143cardiac left ventricle morphogenesis (GO:0003214)2.43494324
144negative regulation of striated muscle cell differentiation (GO:0051154)2.42938398
145mitochondrion localization (GO:0051646)2.41161310
146peptidyl-tyrosine autophosphorylation (GO:0038083)2.40935544
147female mating behavior (GO:0060180)2.39901295
148cell communication involved in cardiac conduction (GO:0086065)2.39619739
149modified amino acid transport (GO:0072337)2.39258809
150cell-cell junction maintenance (GO:0045217)2.38308264
151retina homeostasis (GO:0001895)2.36911316
152plasma membrane repair (GO:0001778)2.34694254
153terpenoid metabolic process (GO:0006721)2.34146965
154regulation of synapse structural plasticity (GO:0051823)2.33181020
155retinoic acid receptor signaling pathway (GO:0048384)2.32468939
156embryonic retina morphogenesis in camera-type eye (GO:0060059)2.30845887
157cardiac myofibril assembly (GO:0055003)2.30031823
158regulation of ARF protein signal transduction (GO:0032012)2.29823467
159positive regulation of synapse maturation (GO:0090129)2.26437152
160cardiac muscle contraction (GO:0060048)2.24409405
161negative regulation of Rho protein signal transduction (GO:0035024)2.24089524
162cell junction maintenance (GO:0034331)2.22646408
163actin-myosin filament sliding (GO:0033275)2.22538022
164muscle filament sliding (GO:0030049)2.22538022
165layer formation in cerebral cortex (GO:0021819)2.21703318
166regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.20924124
167gamma-aminobutyric acid signaling pathway (GO:0007214)2.19961035
168synaptic vesicle exocytosis (GO:0016079)2.19377685
169negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.17735504
170innervation (GO:0060384)2.15212130
171positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.15098488
172potassium ion export (GO:0071435)2.12411405
173neuronal ion channel clustering (GO:0045161)2.09871109
174detection of temperature stimulus (GO:0016048)2.07583741
175eye morphogenesis (GO:0048592)2.07432733
176regulation of voltage-gated calcium channel activity (GO:1901385)2.06540810
177negative regulation of stress fiber assembly (GO:0051497)2.06137232
178cellular sodium ion homeostasis (GO:0006883)2.06075799
179alanine transport (GO:0032328)2.06022630
180eye photoreceptor cell development (GO:0042462)2.05872441
181regulation of calcium ion transmembrane transporter activity (GO:1901019)2.05823229
182regulation of calcium ion transmembrane transport (GO:1903169)2.05823229
183protein localization to synapse (GO:0035418)2.04666066
184melanin biosynthetic process (GO:0042438)10.8692547

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.28710063
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.24034167
3TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.51604603
4RACK7_27058665_Chip-Seq_MCF-7_Human2.45985678
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.39965046
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.35989696
7ELK3_25401928_ChIP-Seq_HUVEC_Human2.26944103
8ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.24197046
9P68_20966046_ChIP-Seq_HELA_Human2.19709976
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.15068276
11DROSHA_22980978_ChIP-Seq_HELA_Human2.06681643
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.05852319
13IKZF1_21737484_ChIP-ChIP_HCT116_Human2.03598097
14VDR_21846776_ChIP-Seq_THP-1_Human1.94898777
15CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.92006449
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.90453319
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.90073779
18SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.89356720
19* EZH2_27294783_Chip-Seq_ESCs_Mouse1.87813201
20RNF2_18974828_ChIP-Seq_MESCs_Mouse1.87540499
21EZH2_18974828_ChIP-Seq_MESCs_Mouse1.87540499
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.84894789
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84335996
24EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.81362851
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.80553946
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.77689298
27KDM2B_26808549_Chip-Seq_K562_Human1.77083904
28SMC4_20622854_ChIP-Seq_HELA_Human1.74175932
29WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.73791447
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.72875641
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.71699123
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.71676042
33NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.70497474
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.70162723
35* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.67812491
36* TCF7_22412390_ChIP-Seq_EML_Mouse1.67338282
37ZFP281_18757296_ChIP-ChIP_E14_Mouse1.65884904
38AR_21572438_ChIP-Seq_LNCaP_Human1.65414488
39HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.65277769
40JARID2_20064375_ChIP-Seq_MESCs_Mouse1.64796495
41RUNX1_27514584_Chip-Seq_MCF-7_Human1.64591801
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63590813
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.60985964
44MYC_22102868_ChIP-Seq_BL_Human1.59208335
45* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.59034656
46* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.58779242
47ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.57648815
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.57328209
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.56499965
50FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.55521795
51CTCF_27219007_Chip-Seq_ERYTHROID_Human1.55209588
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.54603057
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.52775336
54DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.48953138
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.48505975
56MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.47979517
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.43787622
58RARB_27405468_Chip-Seq_BRAIN_Mouse1.43715642
59SMC3_22415368_ChIP-Seq_MEFs_Mouse1.43085804
60* SA1_27219007_Chip-Seq_ERYTHROID_Human1.42138251
61SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.41599340
62* KDM2B_26808549_Chip-Seq_JURKAT_Human1.41568310
63WT1_25993318_ChIP-Seq_PODOCYTE_Human1.41377815
64REST_18959480_ChIP-ChIP_MESCs_Mouse1.40422531
65NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40311622
66EP300_21415370_ChIP-Seq_HL-1_Mouse1.40246544
67SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.40105220
68KDM2B_26808549_Chip-Seq_DND41_Human1.38400174
69SA1_27219007_Chip-Seq_Bcells_Human1.37676612
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37532895
71REST_21632747_ChIP-Seq_MESCs_Mouse1.36985343
72ZFP281_27345836_Chip-Seq_ESCs_Mouse1.36676865
73TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.35983535
74KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.34647773
75CLOCK_20551151_ChIP-Seq_293T_Human1.33932307
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33399969
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32814173
78STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.32109182
79NFIB_24661679_ChIP-Seq_LUNG_Mouse1.31198995
80TBX20_22328084_ChIP-Seq_HEART_Mouse1.30667077
81TBX20_22080862_ChIP-Seq_HEART_Mouse1.30667077
82DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29829875
83TET1_21451524_ChIP-Seq_MESCs_Mouse1.28108213
84RING1B_27294783_Chip-Seq_ESCs_Mouse1.26391411
85SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.25030376
86EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24504890
87CTCF_27219007_Chip-Seq_Bcells_Human1.24312251
88TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.24129670
89ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.22904347
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.21959244
91TET1_21490601_ChIP-Seq_MESCs_Mouse1.20958967
92BCOR_27268052_Chip-Seq_Bcells_Human1.18840762
93TP53_20018659_ChIP-ChIP_R1E_Mouse1.18702908
94RING1B_27294783_Chip-Seq_NPCs_Mouse1.18375954
95RXRA_24833708_ChIP-Seq_LIVER_Mouse1.18359484
96ESR2_21235772_ChIP-Seq_MCF-7_Human1.18273179
97SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17929769
98MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17855175
99EGR1_19374776_ChIP-ChIP_THP-1_Human1.17095446
100ZNF263_19887448_ChIP-Seq_K562_Human1.15921118
101RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15277833
102SMAD4_21741376_ChIP-Seq_HESCs_Human1.13978104
103RARB_24833708_ChIP-Seq_LIVER_Mouse1.13709719
104PIAS1_25552417_ChIP-Seq_VCAP_Human1.13471009
105SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13253479
106PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.12048142
107GBX2_23144817_ChIP-Seq_PC3_Human1.12029878
108PPARA_22158963_ChIP-Seq_LIVER_Mouse1.10618706
109AR_19668381_ChIP-Seq_PC3_Human1.10287796
110CREB1_26743006_Chip-Seq_LNCaP_Human1.09966441
111MITF_21258399_ChIP-Seq_MELANOMA_Human1.09946028
112* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09083854
113LXR_22292898_ChIP-Seq_THP-1_Human1.08893536
114ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08800386
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08748487
116GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08576495
117GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08221479
118SOX2_21211035_ChIP-Seq_LN229_Gbm1.07325032
119ISL1_27105846_Chip-Seq_CPCs_Mouse1.07324383
120RARA_24833708_ChIP-Seq_LIVER_Mouse1.06976991
121FOXP1_21924763_ChIP-Seq_HESCs_Human1.05543335
122NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03811349
123RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03556928
124NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03005786
125SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02070546
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01685904
127SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00646746
128OCT4_19829295_ChIP-Seq_ESCs_Human1.00049003
129P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99942591
130VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99200266
131PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98842053
132DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98722592
133TCF4_18268006_ChIP-ChIP_LS174T_Human0.98605413
134CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98393484
135CTCF_20526341_ChIP-Seq_ESCs_Human0.97834207
136* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.97754451
137HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96936701
138TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96784635
139FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.96546549
140RXR_22158963_ChIP-Seq_LIVER_Mouse0.96537744
141CTCF_21964334_ChIP-Seq_BJAB-B_Human0.96417457
142OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95521297
143MAF_26560356_Chip-Seq_TH2_Human0.95222504
144TP63_22573176_ChIP-Seq_HFKS_Human0.93682919
145ESR1_20079471_ChIP-ChIP_T-47D_Human0.93474819
146KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93448279
147SMAD3_21741376_ChIP-Seq_HESCs_Human0.93226794
148AHR_22903824_ChIP-Seq_MCF-7_Human0.93175938
149CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92893482
150TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91562183
151* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91227244
152YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90814807
153TP53_23651856_ChIP-Seq_MEFs_Mouse0.90124084
154RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.89444185
155CJUN_26792858_Chip-Seq_BT549_Human0.88377561
156SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.87760456

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation4.73165254
2MP0005257_abnormal_intraocular_pressure4.38672708
3MP0001986_abnormal_taste_sensitivity3.74506772
4* MP0005551_abnormal_eye_electrophysiolog3.40326744
5MP0005423_abnormal_somatic_nervous3.22294278
6MP0003136_yellow_coat_color3.19085079
7MP0004858_abnormal_nervous_system3.13305690
8MP0001324_abnormal_eye_pigmentation3.13096883
9MP0002090_abnormal_vision3.10694959
10MP0005253_abnormal_eye_physiology3.07575223
11MP0004019_abnormal_vitamin_homeostasis3.04414098
12MP0005171_absent_coat_pigmentation3.00189354
13MP0000566_synostosis2.52120193
14MP0002249_abnormal_larynx_morphology2.46444326
15MP0000371_diluted_coat_color2.15414971
16MP0001188_hyperpigmentation2.01628525
17MP0003011_delayed_dark_adaptation12.6601180
18MP0004233_abnormal_muscle_weight1.98283970
19MP0004084_abnormal_cardiac_muscle1.80060727
20MP0000751_myopathy1.78608965
21MP0010030_abnormal_orbit_morphology1.76833119
22MP0005248_abnormal_Harderian_gland1.75530694
23MP0005076_abnormal_cell_differentiation1.71547240
24MP0005391_vision/eye_phenotype1.71210691
25MP0004145_abnormal_muscle_electrophysio1.63248435
26MP0005408_hypopigmentation1.59210438
27MP0005409_darkened_coat_color1.58171797
28MP0004215_abnormal_myocardial_fiber1.53554329
29MP0004885_abnormal_endolymph1.52012359
30MP0001348_abnormal_lacrimal_gland1.47457248
31MP0005195_abnormal_posterior_eye1.44498110
32MP0002089_abnormal_postnatal_growth/wei1.43661784
33MP0001661_extended_life_span1.42693428
34MP0004036_abnormal_muscle_relaxation1.39785487
35MP0002837_dystrophic_cardiac_calcinosis1.37748472
36MP0009780_abnormal_chondrocyte_physiolo1.35356573
37MP0006292_abnormal_olfactory_placode1.33591007
38MP0002075_abnormal_coat/hair_pigmentati1.28765606
39MP0005167_abnormal_blood-brain_barrier1.28259745
40MP0001346_abnormal_lacrimal_gland1.24311066
41MP0000015_abnormal_ear_pigmentation1.19230816
42MP0002092_abnormal_eye_morphology1.17267432
43MP0008438_abnormal_cutaneous_collagen1.16998805
44MP0004130_abnormal_muscle_cell1.15589581
45MP0000678_abnormal_parathyroid_gland1.15049168
46MP0003705_abnormal_hypodermis_morpholog1.14488931
47MP0003950_abnormal_plasma_membrane1.14054699
48MP0005377_hearing/vestibular/ear_phenot1.13212094
49MP0003878_abnormal_ear_physiology1.13212094
50MP0000747_muscle_weakness1.12613930
51MP0002098_abnormal_vibrissa_morphology1.12282475
52MP0009053_abnormal_anal_canal1.06757414
53MP0004043_abnormal_pH_regulation1.06501249
54MP0004272_abnormal_basement_membrane1.06441989
55MP0005670_abnormal_white_adipose1.03589001
56MP0005394_taste/olfaction_phenotype1.02263613
57MP0005499_abnormal_olfactory_system1.02263613
58MP0005623_abnormal_meninges_morphology0.98253930
59MP0004782_abnormal_surfactant_physiolog0.98233110
60MP0000749_muscle_degeneration0.96875919
61MP0004859_abnormal_synaptic_plasticity0.96830029
62MP0001879_abnormal_lymphatic_vessel0.96370257
63MP0002233_abnormal_nose_morphology0.95425962
64MP0005197_abnormal_uvea_morphology0.95157786
65MP0001186_pigmentation_phenotype0.94464449
66MP0005174_abnormal_tail_pigmentation0.94455684
67MP0003646_muscle_fatigue0.89480951
68MP0003137_abnormal_impulse_conducting0.88522808
69MP0003938_abnormal_ear_development0.85219558
70MP0004270_analgesia0.85178334
71MP0008775_abnormal_heart_ventricle0.84896649
72MP0008789_abnormal_olfactory_epithelium0.84513428
73MP0008961_abnormal_basal_metabolism0.84425071
74MP0002234_abnormal_pharynx_morphology0.81376020
75MP0000013_abnormal_adipose_tissue0.81061416
76MP0009384_cardiac_valve_regurgitation0.80658147
77MP0004087_abnormal_muscle_fiber0.78263242
78MP0005330_cardiomyopathy0.78092757
79MP0001502_abnormal_circadian_rhythm0.76593587
80MP0002933_joint_inflammation0.73180219
81MP0005193_abnormal_anterior_eye0.73051094
82MP0005275_abnormal_skin_tensile0.72372982
83MP0005503_abnormal_tendon_morphology0.72108966
84MP0005620_abnormal_muscle_contractility0.71577784
85MP0002108_abnormal_muscle_morphology0.70996159
86MP0002116_abnormal_craniofacial_bone0.70928491
87MP0003329_amyloid_beta_deposits0.70556098
88MP0005058_abnormal_lysosome_morphology0.70324781
89MP0006072_abnormal_retinal_apoptosis0.70278880
90MP0001984_abnormal_olfaction0.70244270
91MP0009840_abnormal_foam_cell0.69893618
92MP0002896_abnormal_bone_mineralization0.69519740
93MP0000462_abnormal_digestive_system0.68149592
94MP0003879_abnormal_hair_cell0.67413735
95MP0002269_muscular_atrophy0.67378164
96MP0005666_abnormal_adipose_tissue0.66859514
97MP0002095_abnormal_skin_pigmentation0.66774190
98MP0002229_neurodegeneration0.66181930
99MP0002877_abnormal_melanocyte_morpholog0.65131282
100MP0002752_abnormal_somatic_nervous0.64620769
101MP0002106_abnormal_muscle_physiology0.62990151
102MP0001486_abnormal_startle_reflex0.62325524
103MP0005375_adipose_tissue_phenotype0.61863245
104MP0002932_abnormal_joint_morphology0.59372888
105MP0000163_abnormal_cartilage_morphology0.58650002
106MP0000003_abnormal_adipose_tissue0.58621759
107MP0000627_abnormal_mammary_gland0.58335332
108MP0000759_abnormal_skeletal_muscle0.58209122
109MP0001958_emphysema0.57012249
110MP0005369_muscle_phenotype0.56683797
111MP0000579_abnormal_nail_morphology0.55974836
112MP0009379_abnormal_foot_pigmentation0.55510334
113MP0009672_abnormal_birth_weight0.54973333
114MP0001764_abnormal_homeostasis0.54659010
115MP0010630_abnormal_cardiac_muscle0.54516744
116MP0003635_abnormal_synaptic_transmissio0.54287993
117MP0003634_abnormal_glial_cell0.53714535
118MP0003115_abnormal_respiratory_system0.53412789
119MP0002127_abnormal_cardiovascular_syste0.53188433
120MP0008569_lethality_at_weaning0.52544233
121MP0002882_abnormal_neuron_morphology0.52311310
122MP0000762_abnormal_tongue_morphology0.52194949
123MP0000534_abnormal_ureter_morphology0.51923645
124MP0004381_abnormal_hair_follicle0.51764898
125MP0010234_abnormal_vibrissa_follicle0.51043286
126MP0004185_abnormal_adipocyte_glucose0.50530321
127MP0003755_abnormal_palate_morphology0.48013206
128MP0001340_abnormal_eyelid_morphology0.47903081
129MP0001299_abnormal_eye_distance/0.47067908
130MP0005023_abnormal_wound_healing0.46948480
131MP0003942_abnormal_urinary_system0.46545943
132MP0003385_abnormal_body_wall0.46441297
133MP0003566_abnormal_cell_adhesion0.46101425
134MP0000428_abnormal_craniofacial_morphol0.45774471
135MP0010368_abnormal_lymphatic_system0.45383763
136MP0003283_abnormal_digestive_organ0.44669305
137MP0000631_abnormal_neuroendocrine_gland0.44224624
138MP0003453_abnormal_keratinocyte_physiol0.44013526
139MP0000767_abnormal_smooth_muscle0.43919194
140MP0000750_abnormal_muscle_regeneration0.43469899
141MP0000733_abnormal_muscle_development0.43447945
142MP0002697_abnormal_eye_size0.43024004
143MP0000537_abnormal_urethra_morphology0.42735774
144MP0003119_abnormal_digestive_system0.41526096
145MP0002332_abnormal_exercise_endurance0.40405902
146MP0006138_congestive_heart_failure0.40026763

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fovea (HP:0000493)9.04809870
2Hypopigmentation of the fundus (HP:0007894)8.96824774
3Attenuation of retinal blood vessels (HP:0007843)8.65764502
4Decreased central vision (HP:0007663)6.98002448
5Hypoplasia of the fovea (HP:0007750)6.74147598
6Aplasia/Hypoplasia of the fovea (HP:0008060)6.74147598
7Keratoconus (HP:0000563)6.45586391
8Increased corneal curvature (HP:0100692)6.45586391
9Aplasia/Hypoplasia of the macula (HP:0008059)5.19570637
10Abnormal rod and cone electroretinograms (HP:0008323)4.90732090
11Aplasia/Hypoplasia affecting the retina (HP:0008061)4.84983976
12Constricted visual fields (HP:0001133)4.68896607
13Scotoma (HP:0000575)4.54368220
14Choroideremia (HP:0001139)4.50165283
15Bony spicule pigmentary retinopathy (HP:0007737)4.31643266
16Congenital stationary night blindness (HP:0007642)4.11698682
17Central scotoma (HP:0000603)3.84577357
18Blue irides (HP:0000635)3.82407799
19Urethral obstruction (HP:0000796)3.69676799
20Turricephaly (HP:0000262)3.60674989
21Termporal pattern (HP:0011008)3.60507394
22Insidious onset (HP:0003587)3.60507394
23Abolished electroretinogram (ERG) (HP:0000550)3.31913743
24Ocular albinism (HP:0001107)3.17301556
25Exercise-induced muscle cramps (HP:0003710)3.15491092
26Cervical subluxation (HP:0003308)3.14179556
27Nonprogressive disorder (HP:0003680)3.07569833
28Flat cornea (HP:0007720)2.96355305
29Bell-shaped thorax (HP:0001591)2.96329431
30Broad face (HP:0000283)2.95829393
31Duplicated collecting system (HP:0000081)2.93550291
32Type II diabetes mellitus (HP:0005978)2.89761583
33Ventricular tachycardia (HP:0004756)2.84518151
34Ulnar claw (HP:0001178)2.81881485
35Iris hypopigmentation (HP:0007730)2.81877318
36Abnormality of macular pigmentation (HP:0008002)2.76065987
37Testicular atrophy (HP:0000029)2.71272005
38Abnormality of the renal collecting system (HP:0004742)2.67461008
39Abnormality of the phalanges of the hallux (HP:0010057)2.66754856
40Joint stiffness (HP:0001387)2.64019011
41Widely patent fontanelles and sutures (HP:0004492)2.63929044
42Obstructive sleep apnea (HP:0002870)2.60824470
43Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.56412824
44Segmental peripheral demyelination/remyelination (HP:0003481)2.54669494
45Peripheral hypomyelination (HP:0007182)2.45373398
46Flat capital femoral epiphysis (HP:0003370)2.40296801
47Abnormality of the distal phalanx of the thumb (HP:0009617)2.40169080
48Abnormality of the aortic arch (HP:0012303)2.38419172
49Septo-optic dysplasia (HP:0100842)2.37514690
50Intestinal fistula (HP:0100819)2.34630979
51Photophobia (HP:0000613)2.32595565
52Hypoplastic ischia (HP:0003175)2.29705880
53Exercise-induced myalgia (HP:0003738)2.27658784
54Ureteral duplication (HP:0000073)2.25523874
55Hand muscle atrophy (HP:0009130)2.23754543
56Abnormality of the pons (HP:0007361)2.23293252
57Natal tooth (HP:0000695)2.21995740
58Seborrheic dermatitis (HP:0001051)2.21378467
59Biconcave vertebral bodies (HP:0004586)2.20831217
60Advanced eruption of teeth (HP:0006288)2.20357982
61Anteriorly placed anus (HP:0001545)2.20296897
62Corneal dystrophy (HP:0001131)2.19488633
63Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.18838756
64Systemic lupus erythematosus (HP:0002725)2.15785879
65Visual hallucinations (HP:0002367)2.14260882
66Upper limb amyotrophy (HP:0009129)2.10328841
67Distal upper limb amyotrophy (HP:0007149)2.10328841
68Asymmetry of the thorax (HP:0001555)2.09829194
69Progressive sensorineural hearing impairment (HP:0000408)2.09289875
703-Methylglutaconic aciduria (HP:0003535)2.07576381
71Cerebral aneurysm (HP:0004944)2.05679291
72Patent foramen ovale (HP:0001655)2.04364742
73Generalized hypopigmentation (HP:0007513)2.03467420
74Type 1 muscle fiber predominance (HP:0003803)2.02227358
75Wide cranial sutures (HP:0010537)2.02003896
76Hemorrhage of the eye (HP:0011885)2.01064794
77Decreased electroretinogram (ERG) amplitude (HP:0000654)12.6723299
78Abnormality of the ischium (HP:0003174)1.96160696
79Dyschromatopsia (HP:0007641)1.95048597
80Abnormality of the calf musculature (HP:0001430)1.94658612
81Complement deficiency (HP:0004431)1.93568645
82Microglossia (HP:0000171)1.93493687
83Septate vagina (HP:0001153)1.92557744
84Mitral regurgitation (HP:0001653)1.92513012
85Abnormal pupillary function (HP:0007686)1.91471921
86Flat occiput (HP:0005469)1.90575976
87Breech presentation (HP:0001623)1.88617492
88Metaphyseal cupping (HP:0003021)1.88607103
89Abnormality of fatty-acid metabolism (HP:0004359)1.88516216
90Vertebral clefting (HP:0008428)1.86142386
91Macular degeneration (HP:0000608)1.85757588
92Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.84154069
93Stereotypic behavior (HP:0000733)1.82394868
94Bronchomalacia (HP:0002780)1.81024945
95Ventricular fibrillation (HP:0001663)1.80908889
96Prolonged QT interval (HP:0001657)1.80805707
97Rectal fistula (HP:0100590)1.80195964
98Rectovaginal fistula (HP:0000143)1.80195964
99Mucopolysacchariduria (HP:0008155)1.79089952
100Urinary glycosaminoglycan excretion (HP:0003541)1.79089952
101Abnormality of polysaccharide metabolism (HP:0011012)1.77752041
102Abnormality of glycosaminoglycan metabolism (HP:0004371)1.77752041
103Abnormality of mucopolysaccharide metabolism (HP:0011020)1.77752041
104Round ear (HP:0100830)1.77212201
105Polar cataract (HP:0010696)1.76721870
106Protruding tongue (HP:0010808)1.76353070
107Abnormality of the sella turcica (HP:0002679)1.74959205
108Prolonged neonatal jaundice (HP:0006579)1.74705101
109Easy fatigability (HP:0003388)1.74697828
110Abnormal number of erythroid precursors (HP:0012131)1.74244442
111Heterotopia (HP:0002282)1.74209179
112Pulmonary artery stenosis (HP:0004415)1.73350446
113Freckling (HP:0001480)1.72971377
114Abnormality of cells of the erythroid lineage (HP:0012130)1.72927878
115Aortic aneurysm (HP:0004942)1.72823352
116Laryngomalacia (HP:0001601)1.71857545
117Vaginal fistula (HP:0004320)1.71673336
118Atelectasis (HP:0100750)1.71334710
119Ulnar bowing (HP:0003031)1.70798841
120Broad thumb (HP:0011304)1.69978529
121Flattened epiphyses (HP:0003071)1.69534987
122Cortical visual impairment (HP:0100704)1.69144397
123Broad metatarsal (HP:0001783)1.68946009
124Shallow orbits (HP:0000586)1.66500303
125Genetic anticipation (HP:0003743)1.66439030
126Difficulty running (HP:0009046)1.66411735
127Calf muscle hypertrophy (HP:0008981)1.66243175
128Sparse lateral eyebrow (HP:0005338)1.65932231
129Partial duplication of thumb phalanx (HP:0009944)1.65245678
130Thin bony cortex (HP:0002753)1.64713537
131Muscle fiber atrophy (HP:0100295)1.64564535
132Arterial tortuosity (HP:0005116)1.63376133
133Sudden death (HP:0001699)1.62371820
134Pigmentary retinal degeneration (HP:0001146)1.59187383
135Protrusio acetabuli (HP:0003179)1.58810137
136EMG: myopathic abnormalities (HP:0003458)1.58159443
137Muscle fiber splitting (HP:0003555)1.57896355
138Albinism (HP:0001022)1.57880321
139Hypoventilation (HP:0002791)1.57487735
140Myoglobinuria (HP:0002913)1.57013257
141Epileptic encephalopathy (HP:0200134)1.54928980
142Muscle hypertrophy of the lower extremities (HP:0008968)1.50279647
143Right ventricular cardiomyopathy (HP:0011663)1.49860470
144Wide nasal bridge (HP:0000431)1.48107211
145Limb-girdle muscle atrophy (HP:0003797)1.47726058
146Vascular tortuosity (HP:0004948)1.47055012
147Subacute progressive viral hepatitis (HP:0006572)1.46651487
148Action tremor (HP:0002345)1.45880884
149Syncope (HP:0001279)1.44271867
150Scapular winging (HP:0003691)1.44229157
151Absence seizures (HP:0002121)1.43817844
152Hyporeflexia of lower limbs (HP:0002600)1.42582074
153Febrile seizures (HP:0002373)1.41763089
154Myokymia (HP:0002411)1.41116368
155Frequent falls (HP:0002359)1.40866136
156Hemiparesis (HP:0001269)1.40542974
157Atrial fibrillation (HP:0005110)1.40512860
158Absent septum pellucidum (HP:0001331)1.39866640
159Subcapsular cataract (HP:0000523)1.39782761
160Annular pancreas (HP:0001734)1.38896583
161Posterior subcapsular cataract (HP:0007787)1.37879949
162Asymmetric septal hypertrophy (HP:0001670)1.37154926
163Generalized hypopigmentation of hair (HP:0011358)1.37058777
164Hypermetropia (HP:0000540)1.35969122
165Chorioretinal atrophy (HP:0000533)1.32814389
166Increased variability in muscle fiber diameter (HP:0003557)1.30592985
167Ventricular arrhythmia (HP:0004308)1.30223364
168Aortic dissection (HP:0002647)1.28954776
169Primary atrial arrhythmia (HP:0001692)1.27866317
170Pointed chin (HP:0000307)1.26773691
171Aneurysm (HP:0002617)1.25007666
172Mitral valve prolapse (HP:0001634)1.20949522
173Increased connective tissue (HP:0009025)1.19774291
174Myopathic facies (HP:0002058)1.19048243
175Cerebral inclusion bodies (HP:0100314)1.17746363
176Muscle fiber inclusion bodies (HP:0100299)1.17604465

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CA6.67287676
2PKN23.22685960
3GRK13.12996861
4TTN2.78664706
5OBSCN2.77102330
6PAK62.59358589
7TRIB32.43979705
8PHKG12.30488811
9PHKG22.30488811
10KSR22.11520249
11DDR22.02151972
12RIPK12.02006155
13CDK122.00455972
14PRKD31.97858465
15MST1R1.95391479
16CLK11.95276710
17MAP3K91.94607361
18LATS11.87446408
19BMX1.87420579
20PDK21.80752168
21MET1.78098936
22WNK11.75275222
23LMTK21.71755743
24CAMK1D1.65679079
25MAP3K21.59296180
26PAK31.57392370
27EPHA21.48941400
28CAMK1G1.48202295
29TGFBR21.47611034
30PTK61.45003235
31SMG11.40878056
32CHUK1.40271967
33MAP2K61.36241762
34CAMKK11.35888031
35CAMKK21.35310166
36KSR11.23585437
37MUSK1.19694290
38PAK21.17346119
39MAP3K71.13768905
40PIM21.09899082
41DMPK1.08534012
42RET1.07175375
43SIK11.06829538
44PIK3CG1.05757052
45NEK10.97879524
46RAF10.94748661
47CAMK10.94142241
48TAOK10.93973437
49BRD40.92459035
50DAPK20.89031369
51PTK20.88871199
52MAPK150.88784621
53MARK20.87098725
54MAP2K30.87084399
55MAPKAPK30.86651485
56RPS6KA20.86480554
57TIE10.86244063
58WNK40.86158943
59EPHA40.83466390
60EEF2K0.83064346
61MTOR0.81655571
62PDGFRA0.80851257
63EPHB10.79388841
64MARK10.76453565
65NEK60.75835001
66SCYL20.73949855
67MYLK0.72986685
68MINK10.71008999
69PKN10.70906001
70PDK40.70244398
71PDK30.70244398
72STK390.70214403
73NTRK10.69657146
74MAP3K100.68598170
75NTRK30.68474398
76FGFR10.67930629
77SIK20.67276413
78MARK30.65713812
79PRKCH0.64904110
80CAMK40.64344910
81NEK90.64127917
82PRKD10.63725509
83TGFBR10.63368758
84FGFR40.63030606
85PDPK10.61412401
86AKT20.60546750
87FLT30.60325715
88MAP3K140.60293122
89PRKD20.60049774
90RPS6KL10.59699750
91RPS6KC10.59699750
92PRPF4B0.58804797
93DYRK1A0.58159387
94BRAF0.58151326
95SGK2230.57951294
96SGK4940.57951294
97CAMK2B0.57128745
98ICK0.56555862
99FER0.55643259
100MAP3K40.55166789
101STK40.54671866
102MAPK120.54335163
103BMPR1B0.53428382
104LATS20.53015737
105CDK50.52152640
106RPS6KA60.52113475
107ROCK20.51501533
108CAMK2G0.51187677
109CDC42BPA0.50939342
110KDR0.50850236
111CAMK2D0.50364635
112TYRO30.50091421
113TESK20.48984561
114ROCK10.48973998
115ALK0.48790848
116PDK10.48785497
117AKT30.48451437
118MAPK100.47641764
119UHMK10.47521779
120STK110.45806832
121SGK20.45613688
122SGK30.45589997
123PRKCI0.45298635
124HIPK20.45239336
125PRKAA10.45116537
126RPS6KB20.45107982
127PAK40.44615174
128BLK0.44205622
129STK380.43987835
130ERN10.43874189
131MAP3K130.43532054
132PDGFRB0.42531616
133PASK0.42519700
134DYRK1B0.40644519
135SGK10.40375479
136LRRK20.40294126
137JAK20.40150329
138MAP2K10.39667204
139INSRR0.39495410
140ERBB20.39137758
141RPS6KA10.38936750
142MAP2K40.37347155
143NME20.37287675
144GSK3A0.37057814
145ARAF0.37007633
146CSNK1D0.36947402
147TNK20.36346469
148EPHA30.36195339
149PRKAA20.36082534
150MAP3K110.35778401
151IKBKB0.35465866
152FGFR30.31209162

Predicted pathways (KEGG)

RankGene SetZ-score
1Retinol metabolism_Homo sapiens_hsa008303.50146709
2Notch signaling pathway_Homo sapiens_hsa043302.95121998
3Cyanoamino acid metabolism_Homo sapiens_hsa004602.73830925
4Arginine biosynthesis_Homo sapiens_hsa002202.64727570
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.58930996
6Tyrosine metabolism_Homo sapiens_hsa003502.37679017
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.37465856
8Phototransduction_Homo sapiens_hsa047442.19058681
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.07145026
10Dilated cardiomyopathy_Homo sapiens_hsa054142.02936316
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.84089521
12ABC transporters_Homo sapiens_hsa020101.70872457
13GABAergic synapse_Homo sapiens_hsa047271.65235881
14Vitamin digestion and absorption_Homo sapiens_hsa049771.55644854
15Melanogenesis_Homo sapiens_hsa049161.55636654
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55311968
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.55271924
18Renin secretion_Homo sapiens_hsa049241.50325458
19Salivary secretion_Homo sapiens_hsa049701.50243237
20Nicotine addiction_Homo sapiens_hsa050331.48196105
21Oxytocin signaling pathway_Homo sapiens_hsa049211.47133670
22Circadian entrainment_Homo sapiens_hsa047131.46476972
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45940882
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42624253
25Central carbon metabolism in cancer_Homo sapiens_hsa052301.42591122
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41100674
27Gastric acid secretion_Homo sapiens_hsa049711.39455806
28Vitamin B6 metabolism_Homo sapiens_hsa007501.34122410
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.32426982
30Olfactory transduction_Homo sapiens_hsa047401.32157705
31Type II diabetes mellitus_Homo sapiens_hsa049301.26512194
32Bile secretion_Homo sapiens_hsa049761.25975678
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.25891781
34Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.24514076
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.23682172
36Tight junction_Homo sapiens_hsa045301.21459714
37Renal cell carcinoma_Homo sapiens_hsa052111.20836118
38mTOR signaling pathway_Homo sapiens_hsa041501.19052580
39Glioma_Homo sapiens_hsa052141.18627604
40MicroRNAs in cancer_Homo sapiens_hsa052061.16838247
41Morphine addiction_Homo sapiens_hsa050321.16667638
42Cholinergic synapse_Homo sapiens_hsa047251.14312374
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12835673
44Synaptic vesicle cycle_Homo sapiens_hsa047211.12553355
45Hedgehog signaling pathway_Homo sapiens_hsa043401.09742261
46Insulin secretion_Homo sapiens_hsa049111.09713748
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08614879
48Estrogen signaling pathway_Homo sapiens_hsa049151.07926880
49Acute myeloid leukemia_Homo sapiens_hsa052211.06429191
50Nitrogen metabolism_Homo sapiens_hsa009101.04905628
51Carbohydrate digestion and absorption_Homo sapiens_hsa049731.04400965
52Inositol phosphate metabolism_Homo sapiens_hsa005621.04170787
53Dorso-ventral axis formation_Homo sapiens_hsa043201.04103915
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.03243650
55Vascular smooth muscle contraction_Homo sapiens_hsa042701.01189662
56Wnt signaling pathway_Homo sapiens_hsa043100.99737887
57Cardiac muscle contraction_Homo sapiens_hsa042600.97886282
58Endometrial cancer_Homo sapiens_hsa052130.97444232
59GnRH signaling pathway_Homo sapiens_hsa049120.97437693
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97434502
61Long-term potentiation_Homo sapiens_hsa047200.96881742
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96712790
63Focal adhesion_Homo sapiens_hsa045100.96014013
64Phenylalanine metabolism_Homo sapiens_hsa003600.95036171
65Ribosome_Homo sapiens_hsa030100.93075941
66Small cell lung cancer_Homo sapiens_hsa052220.91060639
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90744880
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90357715
69Insulin signaling pathway_Homo sapiens_hsa049100.89801926
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89186246
71Glucagon signaling pathway_Homo sapiens_hsa049220.88627834
72ErbB signaling pathway_Homo sapiens_hsa040120.88322025
73Fatty acid biosynthesis_Homo sapiens_hsa000610.88028085
74ECM-receptor interaction_Homo sapiens_hsa045120.87833905
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84881617
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84359862
77Fatty acid elongation_Homo sapiens_hsa000620.83581762
78cAMP signaling pathway_Homo sapiens_hsa040240.83525634
79HIF-1 signaling pathway_Homo sapiens_hsa040660.83409259
80Calcium signaling pathway_Homo sapiens_hsa040200.81188702
81Protein digestion and absorption_Homo sapiens_hsa049740.81188253
82Chronic myeloid leukemia_Homo sapiens_hsa052200.80929171
83Proteoglycans in cancer_Homo sapiens_hsa052050.79711138
84Sulfur relay system_Homo sapiens_hsa041220.79244593
85Prostate cancer_Homo sapiens_hsa052150.77367028
86Dopaminergic synapse_Homo sapiens_hsa047280.76293217
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75651913
88Insulin resistance_Homo sapiens_hsa049310.75252059
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73976632
90Amphetamine addiction_Homo sapiens_hsa050310.73928070
91VEGF signaling pathway_Homo sapiens_hsa043700.72633311
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72525227
93Fatty acid metabolism_Homo sapiens_hsa012120.72051462
94Lysine degradation_Homo sapiens_hsa003100.70540933
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.70286042
96Gap junction_Homo sapiens_hsa045400.70194352
97FoxO signaling pathway_Homo sapiens_hsa040680.69990479
98TGF-beta signaling pathway_Homo sapiens_hsa043500.69298104
99Axon guidance_Homo sapiens_hsa043600.69280437
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68569110
101Arginine and proline metabolism_Homo sapiens_hsa003300.68558610
102Complement and coagulation cascades_Homo sapiens_hsa046100.68236679
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66782668
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65120588
105Glutamatergic synapse_Homo sapiens_hsa047240.65071871
106Histidine metabolism_Homo sapiens_hsa003400.63941395
107Colorectal cancer_Homo sapiens_hsa052100.63271539
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.62609704
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62486966
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61930879
111Lysosome_Homo sapiens_hsa041420.60714724
112Thyroid hormone synthesis_Homo sapiens_hsa049180.60680065
113Rap1 signaling pathway_Homo sapiens_hsa040150.60635017
114Other glycan degradation_Homo sapiens_hsa005110.60393974
115Taste transduction_Homo sapiens_hsa047420.59509924
116Viral myocarditis_Homo sapiens_hsa054160.58732588
117Amoebiasis_Homo sapiens_hsa051460.58531015
118Circadian rhythm_Homo sapiens_hsa047100.58420878
119Alcoholism_Homo sapiens_hsa050340.57115233
120AMPK signaling pathway_Homo sapiens_hsa041520.56521516
121Adherens junction_Homo sapiens_hsa045200.56218411
122Ras signaling pathway_Homo sapiens_hsa040140.56207520
123Non-small cell lung cancer_Homo sapiens_hsa052230.56185930
124Pancreatic secretion_Homo sapiens_hsa049720.55146754
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.55051269
126PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54669652
127Glycosaminoglycan degradation_Homo sapiens_hsa005310.54502637
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54194471
129Fatty acid degradation_Homo sapiens_hsa000710.53210755
130Biosynthesis of amino acids_Homo sapiens_hsa012300.52442354
131Endocytosis_Homo sapiens_hsa041440.52278944
132Arachidonic acid metabolism_Homo sapiens_hsa005900.51403388
133Hippo signaling pathway_Homo sapiens_hsa043900.51283715
134Basal cell carcinoma_Homo sapiens_hsa052170.51199094
135Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50992042
136Prolactin signaling pathway_Homo sapiens_hsa049170.49534067
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.49430648
138Pancreatic cancer_Homo sapiens_hsa052120.48962837
139Choline metabolism in cancer_Homo sapiens_hsa052310.48508775
140AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48406904
141Melanoma_Homo sapiens_hsa052180.47917270
142One carbon pool by folate_Homo sapiens_hsa006700.47793692
143mRNA surveillance pathway_Homo sapiens_hsa030150.44232248
144Prion diseases_Homo sapiens_hsa050200.44168454
145Ovarian steroidogenesis_Homo sapiens_hsa049130.42994498
146Pathways in cancer_Homo sapiens_hsa052000.40738415

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