SLC17A8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a vesicular glutamate transporter. The encoded protein transports the neurotransmitter glutamate into synaptic vesicles before it is released into the synaptic cleft. Mutations in this gene are the cause of autosomal-dominant nonsyndromic type 25 deafness. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of action potential (GO:0045760)8.97295832
2tachykinin receptor signaling pathway (GO:0007217)8.68961976
3positive regulation of digestive system process (GO:0060456)7.01207448
4positive regulation of synaptic transmission, GABAergic (GO:0032230)6.23189476
5negative regulation of heart rate (GO:0010459)6.19390676
6indole-containing compound catabolic process (GO:0042436)6.08150310
7indolalkylamine catabolic process (GO:0046218)6.08150310
8tryptophan catabolic process (GO:0006569)6.08150310
9aromatic amino acid family catabolic process (GO:0009074)5.91991347
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.66507271
11L-phenylalanine catabolic process (GO:0006559)5.66507271
12tryptophan metabolic process (GO:0006568)5.60461942
13regulation of action potential (GO:0098900)5.29664178
14L-phenylalanine metabolic process (GO:0006558)5.21079354
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.21079354
16regulation of glucocorticoid secretion (GO:2000849)5.19751148
17kynurenine metabolic process (GO:0070189)5.17615594
18angiotensin maturation (GO:0002003)5.16690137
19positive regulation of steroid hormone secretion (GO:2000833)5.06503444
20bile acid biosynthetic process (GO:0006699)4.81081244
21amine catabolic process (GO:0009310)4.65227098
22cellular biogenic amine catabolic process (GO:0042402)4.65227098
23indolalkylamine metabolic process (GO:0006586)4.64686011
24positive regulation of renal sodium excretion (GO:0035815)4.61209580
25epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.43776774
26aromatic amino acid family metabolic process (GO:0009072)4.37085945
27triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.36679854
28regulation of fibrinolysis (GO:0051917)4.27884263
29regulation of guanylate cyclase activity (GO:0031282)4.22460782
30behavioral response to nicotine (GO:0035095)4.20130954
31negative regulation of lipase activity (GO:0060192)4.17671478
32regulation of corticosteroid hormone secretion (GO:2000846)4.14963730
33NAD biosynthetic process (GO:0009435)4.08801604
34imidazole-containing compound metabolic process (GO:0052803)4.07482910
35regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.06666623
36auditory receptor cell differentiation (GO:0042491)4.05851942
37high-density lipoprotein particle remodeling (GO:0034375)4.05685992
38bile acid metabolic process (GO:0008206)4.05118824
39nucleobase catabolic process (GO:0046113)4.01951678
40N-acetylneuraminate metabolic process (GO:0006054)3.96689038
41lipoprotein transport (GO:0042953)3.95160869
42glyoxylate metabolic process (GO:0046487)3.95099144
43epithelial cilium movement (GO:0003351)3.91736652
44fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.90976034
45regulation of cholesterol esterification (GO:0010872)3.90775093
46phospholipid efflux (GO:0033700)3.78277630
47presynaptic membrane organization (GO:0097090)3.77951993
48complement activation, alternative pathway (GO:0006957)3.77242733
49regulation of protein activation cascade (GO:2000257)3.72894603
50alpha-linolenic acid metabolic process (GO:0036109)3.69640158
51urea cycle (GO:0000050)3.67681441
52urea metabolic process (GO:0019627)3.67681441
53tyrosine metabolic process (GO:0006570)3.66106373
54very long-chain fatty acid metabolic process (GO:0000038)3.65498827
55fat-soluble vitamin biosynthetic process (GO:0042362)3.63583728
56presynaptic membrane assembly (GO:0097105)3.62526595
57protein carboxylation (GO:0018214)3.60541069
58peptidyl-glutamic acid carboxylation (GO:0017187)3.60541069
59triglyceride homeostasis (GO:0070328)3.59506374
60acylglycerol homeostasis (GO:0055090)3.59506374
61bile acid and bile salt transport (GO:0015721)3.58019697
62blood coagulation, intrinsic pathway (GO:0007597)3.57138001
63low-density lipoprotein particle remodeling (GO:0034374)3.55549234
64cellular glucuronidation (GO:0052695)3.55295348
65linoleic acid metabolic process (GO:0043651)3.54334127
66protein-lipid complex remodeling (GO:0034368)3.53986332
67macromolecular complex remodeling (GO:0034367)3.53986332
68plasma lipoprotein particle remodeling (GO:0034369)3.53986332
69positive regulation of guanylate cyclase activity (GO:0031284)3.53872879
70negative regulation of fibrinolysis (GO:0051918)3.52573913
71coenzyme catabolic process (GO:0009109)3.52104791
72regulation of digestive system process (GO:0044058)3.50960710
73reverse cholesterol transport (GO:0043691)3.47916356
74cilium movement (GO:0003341)3.45141451
75nitrogen cycle metabolic process (GO:0071941)3.44673995
76serine family amino acid catabolic process (GO:0009071)3.44638623
77nicotinamide nucleotide biosynthetic process (GO:0019359)3.43849191
78pyridine nucleotide biosynthetic process (GO:0019363)3.43849191
79glomerulus development (GO:0032835)3.43482402
80benzene-containing compound metabolic process (GO:0042537)3.41536840
81very-low-density lipoprotein particle assembly (GO:0034379)3.41426704
82regulation of complement activation (GO:0030449)3.40698354
83uronic acid metabolic process (GO:0006063)3.40589046
84glucuronate metabolic process (GO:0019585)3.40589046
85fatty acid elongation (GO:0030497)3.40293818
86cholesterol efflux (GO:0033344)3.39762354
87amino-acid betaine metabolic process (GO:0006577)3.38339971
88axonemal dynein complex assembly (GO:0070286)3.37625219
89epoxygenase P450 pathway (GO:0019373)3.37501904
90alpha-amino acid catabolic process (GO:1901606)3.36784736
91fat-soluble vitamin catabolic process (GO:0042363)3.34137180
92vitamin catabolic process (GO:0009111)3.34137180
93cilium or flagellum-dependent cell motility (GO:0001539)3.32279950
94vitamin A metabolic process (GO:0006776)3.30366532
95regulation of triglyceride catabolic process (GO:0010896)3.30358397
96fucose catabolic process (GO:0019317)3.26937470
97L-fucose metabolic process (GO:0042354)3.26937470
98L-fucose catabolic process (GO:0042355)3.26937470
99indole-containing compound metabolic process (GO:0042430)3.26095822
100cellular ketone body metabolic process (GO:0046950)3.23146934
101homocysteine metabolic process (GO:0050667)3.18797536
102phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.15678213
103neuronal stem cell maintenance (GO:0097150)3.14067405
104long-term memory (GO:0007616)3.13581322
105intestinal absorption (GO:0050892)3.10948871
106neuron fate determination (GO:0048664)3.10533319
107glycerol metabolic process (GO:0006071)3.09410241
108regulation of phospholipase A2 activity (GO:0032429)3.08750274
109regulation of steroid hormone secretion (GO:2000831)3.08224206
110negative regulation of sterol transport (GO:0032372)3.07864899
111negative regulation of cholesterol transport (GO:0032375)3.07864899
112pyrimidine nucleobase catabolic process (GO:0006208)3.07165038
113opsonization (GO:0008228)3.05931346
114drinking behavior (GO:0042756)3.05680202
115cellular amino acid catabolic process (GO:0009063)3.05519922
116fat-soluble vitamin metabolic process (GO:0006775)3.03756353
117aldehyde catabolic process (GO:0046185)3.03128950
118sulfation (GO:0051923)3.03034474
119alkaloid metabolic process (GO:0009820)3.02687610
120negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.02545376
121transepithelial transport (GO:0070633)3.01327615
122transmission of nerve impulse (GO:0019226)3.01219251
123regulation of pigment cell differentiation (GO:0050932)3.01204714
124response to auditory stimulus (GO:0010996)3.00766385
125neuronal action potential propagation (GO:0019227)2.99577757
126fibrinolysis (GO:0042730)2.98653881
127protein activation cascade (GO:0072376)2.94818990
128phenol-containing compound catabolic process (GO:0019336)2.94576798
129cytolysis (GO:0019835)2.90958955
130regulation of synaptic transmission, GABAergic (GO:0032228)2.89239541
131drug transmembrane transport (GO:0006855)2.88321258
1323-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.87941538
133purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.87941538
134positive regulation of cellular amine metabolic process (GO:0033240)2.87652072
135regulation of renal sodium excretion (GO:0035813)2.84655618
136drug metabolic process (GO:0017144)2.84593274
137plasma lipoprotein particle assembly (GO:0034377)2.83615569
138negative regulation of gene silencing (GO:0060969)2.83609201
139sulfur amino acid catabolic process (GO:0000098)2.81751279
140vitamin biosynthetic process (GO:0009110)2.81569993
141axonal fasciculation (GO:0007413)2.80447791
142mechanoreceptor differentiation (GO:0042490)2.80254344
143androgen biosynthetic process (GO:0006702)2.79869729
144cysteine metabolic process (GO:0006534)2.78886064
145retinal ganglion cell axon guidance (GO:0031290)2.78474637
146arginine metabolic process (GO:0006525)2.75914678
147plasma lipoprotein particle organization (GO:0071827)2.75866941
148ketone body metabolic process (GO:1902224)2.75141163
149carboxylic acid catabolic process (GO:0046395)2.75113202
150organic acid catabolic process (GO:0016054)2.75113202
151neurotransmitter catabolic process (GO:0042135)2.74609436
152glutamate metabolic process (GO:0006536)2.74177326
153neuronal action potential (GO:0019228)2.74152465
154startle response (GO:0001964)2.73240663
155nucleotide transmembrane transport (GO:1901679)2.71938257
156alditol metabolic process (GO:0019400)2.70993463
157cofactor catabolic process (GO:0051187)2.69465461
158complement activation, classical pathway (GO:0006958)2.69033289
159regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.68170246
160endocrine process (GO:0050886)2.68170246
161regulation of systemic arterial blood pressure by hormone (GO:0001990)2.68170246
162somite development (GO:0061053)2.67147311
163negative regulation of heart contraction (GO:0045822)2.66406998
164drug catabolic process (GO:0042737)2.65133845
165serotonin metabolic process (GO:0042428)2.64967550
166flavonoid metabolic process (GO:0009812)2.64940533
167pyrimidine nucleoside catabolic process (GO:0046135)2.64486287
168positive regulation of lipoprotein lipase activity (GO:0051006)2.64058608
169positive regulation of triglyceride lipase activity (GO:0061365)2.64058608
170membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.61095667
171positive regulation of mitochondrial fission (GO:0090141)2.61092543
172complement activation (GO:0006956)2.60904912
173pyridine-containing compound biosynthetic process (GO:0072525)2.60092693
174sensory perception of pain (GO:0019233)2.58845863
175regulation of excretion (GO:0044062)2.58769891
176regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.58646072
177sulfate transport (GO:0008272)2.57716768
178cellular anion homeostasis (GO:0030002)2.56979020
179neuron recognition (GO:0008038)2.56362279
180response to pain (GO:0048265)2.55595604
181androgen metabolic process (GO:0008209)2.55533728
182diacylglycerol metabolic process (GO:0046339)2.54451355
183retinal rod cell development (GO:0046548)2.54350624
184regulation of systemic arterial blood pressure (GO:0003073)2.53704145
185quinone biosynthetic process (GO:1901663)2.53203788
186synapse assembly (GO:0007416)2.52633411
187regulation of cGMP biosynthetic process (GO:0030826)2.51426780
188regulation of bile acid biosynthetic process (GO:0070857)2.50519711
189synaptic transmission, glutamatergic (GO:0035249)2.48513786
190peristalsis (GO:0030432)2.48489672
191axon ensheathment in central nervous system (GO:0032291)2.48233622
192central nervous system myelination (GO:0022010)2.48233622
193primary amino compound metabolic process (GO:1901160)2.47042957
194positive regulation of vesicle fusion (GO:0031340)2.46968315
195kidney morphogenesis (GO:0060993)2.46919277
196sulfate transmembrane transport (GO:1902358)2.45103403

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.03488696
2EGR1_23403033_ChIP-Seq_LIVER_Mouse3.72924652
3GBX2_23144817_ChIP-Seq_PC3_Human3.50251509
4EZH2_22144423_ChIP-Seq_EOC_Human2.98906270
5* RXR_22158963_ChIP-Seq_LIVER_Mouse2.97499058
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.46068348
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.40381042
8* LXR_22158963_ChIP-Seq_LIVER_Mouse2.36222216
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25236358
10FUS_26573619_Chip-Seq_HEK293_Human2.23087569
11TAF15_26573619_Chip-Seq_HEK293_Human2.17068258
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.17023755
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.14031311
14JARID2_20064375_ChIP-Seq_MESCs_Mouse1.92910872
15SUZ12_27294783_Chip-Seq_NPCs_Mouse1.91436590
16PCGF2_27294783_Chip-Seq_ESCs_Mouse1.90605511
17BMI1_23680149_ChIP-Seq_NPCS_Mouse1.88825000
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.86855134
19BP1_19119308_ChIP-ChIP_Hs578T_Human1.83543806
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.83515115
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80698936
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.79856838
23NFE2_27457419_Chip-Seq_LIVER_Mouse1.79624895
24CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.78915408
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.77650858
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.77285502
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.71853033
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.70875880
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.70021487
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69971117
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69223464
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68483577
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.67877661
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.66820096
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63447610
36EZH2_27294783_Chip-Seq_NPCs_Mouse1.63255733
37RNF2_18974828_ChIP-Seq_MESCs_Mouse1.61520559
38EZH2_18974828_ChIP-Seq_MESCs_Mouse1.61520559
39* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61099667
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60755140
41AR_21572438_ChIP-Seq_LNCaP_Human1.60433760
42* P300_19829295_ChIP-Seq_ESCs_Human1.60055553
43EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.57997491
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.55413322
45CDX2_20551321_ChIP-Seq_CACO-2_Human1.55384645
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53690682
47IGF1R_20145208_ChIP-Seq_DFB_Human1.51410416
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51220802
49NANOG_18555785_Chip-Seq_ESCs_Mouse1.50892461
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50563861
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49033936
52HTT_18923047_ChIP-ChIP_STHdh_Human1.48511083
53EWS_26573619_Chip-Seq_HEK293_Human1.48248215
54EZH2_27294783_Chip-Seq_ESCs_Mouse1.47993455
55P53_22387025_ChIP-Seq_ESCs_Mouse1.47437929
56SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.47267447
57EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.46989763
58SUZ12_18555785_Chip-Seq_ESCs_Mouse1.46624612
59TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45303701
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44023244
61RUNX1_27457419_Chip-Seq_LIVER_Mouse1.42970201
62STAT3_18555785_Chip-Seq_ESCs_Mouse1.42429677
63P300_18555785_Chip-Seq_ESCs_Mouse1.38667772
64E2F1_18555785_Chip-Seq_ESCs_Mouse1.38487588
65SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36652973
66RNF2_27304074_Chip-Seq_NSC_Mouse1.36179745
67SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34193144
68SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33757740
69CMYC_18555785_Chip-Seq_ESCs_Mouse1.33751225
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33384068
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33278424
72ZNF274_21170338_ChIP-Seq_K562_Hela1.32564340
73SMAD4_21799915_ChIP-Seq_A2780_Human1.31234598
74NMYC_18555785_Chip-Seq_ESCs_Mouse1.30703179
75VDR_22108803_ChIP-Seq_LS180_Human1.29732772
76PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29698989
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28543649
78OCT4_18555785_Chip-Seq_ESCs_Mouse1.27848896
79RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27793790
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.26097478
81SOX2_18555785_Chip-Seq_ESCs_Mouse1.25579474
82MTF2_20144788_ChIP-Seq_MESCs_Mouse1.24964730
83FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.24670555
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23992775
85PU1_27457419_Chip-Seq_LIVER_Mouse1.23736652
86ER_23166858_ChIP-Seq_MCF-7_Human1.23675590
87* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21606630
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21447082
89KLF4_18555785_Chip-Seq_ESCs_Mouse1.19620302
90KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.19346989
91ZFX_18555785_Chip-Seq_ESCs_Mouse1.19264611
92SMAD1_18555785_Chip-Seq_ESCs_Mouse1.19220261
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18216560
94CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.18132038
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17735021
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17735021
97ESRRB_18555785_Chip-Seq_ESCs_Mouse1.17319335
98IRF1_19129219_ChIP-ChIP_H3396_Human1.17126080
99DROSHA_22980978_ChIP-Seq_HELA_Human1.17096746
100* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16809895
101SOX2_21211035_ChIP-Seq_LN229_Gbm1.16625178
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16091072
103CRX_20693478_ChIP-Seq_RETINA_Mouse1.15385083
104CTCF_18555785_Chip-Seq_ESCs_Mouse1.14952946
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14590770
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13985908
107SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.13014885
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10749508
109TAL1_26923725_Chip-Seq_HPCs_Mouse1.09021323
110RNF2_27304074_Chip-Seq_ESCs_Mouse1.08772785
111TCF4_23295773_ChIP-Seq_U87_Human1.08767815
112REST_18959480_ChIP-ChIP_MESCs_Mouse1.08312846
113RING1B_27294783_Chip-Seq_ESCs_Mouse1.07205477
114TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06636626
115CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06370278
116STAT3_23295773_ChIP-Seq_U87_Human1.05791016
117MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05562361
118BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04843995
119BCAT_22108803_ChIP-Seq_LS180_Human1.04265482
120REST_21632747_ChIP-Seq_MESCs_Mouse1.04243001
121IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04242957
122CBP_20019798_ChIP-Seq_JUKART_Human1.04242957
123AHR_22903824_ChIP-Seq_MCF-7_Human1.04190061
124LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04105274
125EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04071329
126KDM2B_26808549_Chip-Seq_REH_Human1.03863777
127PRDM14_20953172_ChIP-Seq_ESCs_Human1.03181769
128KAP1_22055183_ChIP-Seq_ESCs_Mouse1.02627720
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02604701
130RXR_22108803_ChIP-Seq_LS180_Human1.02355604
131TCF4_18268006_ChIP-ChIP_LS174T_Human1.01559293
132TP53_18474530_ChIP-ChIP_U2OS_Human1.00769037
133NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00082497
134KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99931963
135RUNX2_22187159_ChIP-Seq_PCA_Human0.99109706
136AR_25329375_ChIP-Seq_VCAP_Human0.99069920
137HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98984265
138STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98123148
139AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97775938

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.17011675
2MP0005085_abnormal_gallbladder_physiolo5.07230297
3MP0005360_urolithiasis4.87202638
4MP0005365_abnormal_bile_salt4.49716882
5MP0004381_abnormal_hair_follicle3.77336336
6MP0008875_abnormal_xenobiotic_pharmacok3.55133213
7MP0004270_analgesia3.01818257
8MP0003183_abnormal_peptide_metabolism2.84711269
9MP0003252_abnormal_bile_duct2.75305235
10MP0003195_calcinosis2.62479836
11MP0003136_yellow_coat_color2.56259508
12MP0004147_increased_porphyrin_level2.38466405
13MP0001188_hyperpigmentation2.29892677
14MP0004859_abnormal_synaptic_plasticity2.29323252
15MP0009697_abnormal_copulation2.28650787
16MP0004019_abnormal_vitamin_homeostasis2.27484688
17MP0010329_abnormal_lipoprotein_level2.26322790
18MP0002876_abnormal_thyroid_physiology2.15702445
19MP0005075_abnormal_melanosome_morpholog2.06055619
20MP0002653_abnormal_ependyma_morphology2.01935013
21MP0003806_abnormal_nucleotide_metabolis1.90625127
22MP0005451_abnormal_body_composition1.88990715
23MP0003868_abnormal_feces_composition1.88573436
24MP0005645_abnormal_hypothalamus_physiol1.84889976
25MP0006292_abnormal_olfactory_placode1.79858124
26MP0005332_abnormal_amino_acid1.75722547
27MP0004885_abnormal_endolymph1.74159382
28MP0005409_darkened_coat_color1.69370230
29MP0002138_abnormal_hepatobiliary_system1.69167745
30MP0001485_abnormal_pinna_reflex1.67844831
31MP0003011_delayed_dark_adaptation1.66292020
32MP0000566_synostosis1.66187791
33MP0001970_abnormal_pain_threshold1.60368887
34MP0005670_abnormal_white_adipose1.59491472
35MP0003880_abnormal_central_pattern1.58131872
36MP0006276_abnormal_autonomic_nervous1.55402075
37MP0001666_abnormal_nutrient_absorption1.55252438
38MP0000372_irregular_coat_pigmentation1.51218825
39MP0004133_heterotaxia1.51201728
40MP0005408_hypopigmentation1.50096648
41MP0001756_abnormal_urination1.47722256
42MP0005083_abnormal_biliary_tract1.44347080
43MP0001764_abnormal_homeostasis1.41430087
44MP0005647_abnormal_sex_gland1.35904747
45MP0004142_abnormal_muscle_tone1.34664117
46MP0002118_abnormal_lipid_homeostasis1.34597017
47* MP0003635_abnormal_synaptic_transmissio1.33588307
48* MP0001486_abnormal_startle_reflex1.31101106
49MP0005646_abnormal_pituitary_gland1.29801753
50MP0002254_reproductive_system_inflammat1.27647951
51MP0002063_abnormal_learning/memory/cond1.26906107
52MP0009379_abnormal_foot_pigmentation1.26222654
53MP0003787_abnormal_imprinting1.24952289
54MP0000538_abnormal_urinary_bladder1.24731436
55MP0009046_muscle_twitch1.22041463
56MP0001968_abnormal_touch/_nociception1.21592461
57MP0000569_abnormal_digit_pigmentation1.21471195
58MP0005551_abnormal_eye_electrophysiolog1.20878445
59MP0005174_abnormal_tail_pigmentation1.17651431
60MP0009764_decreased_sensitivity_to1.17270101
61MP0002736_abnormal_nociception_after1.16220684
62MP0004782_abnormal_surfactant_physiolog1.15888279
63MP0001440_abnormal_grooming_behavior1.14974273
64MP0002102_abnormal_ear_morphology1.14972059
65MP0002909_abnormal_adrenal_gland1.10457447
66MP0000955_abnormal_spinal_cord1.09462055
67MP0005423_abnormal_somatic_nervous1.08191030
68MP0001502_abnormal_circadian_rhythm1.07719072
69MP0001984_abnormal_olfaction1.06905120
70MP0002277_abnormal_respiratory_mucosa1.04880880
71MP0002733_abnormal_thermal_nociception1.02194225
72MP0001348_abnormal_lacrimal_gland1.02040833
73MP0003119_abnormal_digestive_system0.99574361
74MP0003283_abnormal_digestive_organ0.99457051
75MP0009840_abnormal_foam_cell0.98982961
76MP0005377_hearing/vestibular/ear_phenot0.97584331
77MP0003878_abnormal_ear_physiology0.97584331
78MP0005379_endocrine/exocrine_gland_phen0.97491612
79MP0003718_maternal_effect0.96058630
80MP0000609_abnormal_liver_physiology0.95657664
81MP0000049_abnormal_middle_ear0.94346298
82MP0002638_abnormal_pupillary_reflex0.93054851
83MP0004858_abnormal_nervous_system0.92914116
84MP0003122_maternal_imprinting0.92799886
85MP0008872_abnormal_physiological_respon0.90833689
86* MP0002882_abnormal_neuron_morphology0.90540986
87MP0002928_abnormal_bile_duct0.89554463
88MP0001664_abnormal_digestion0.88871264
89* MP0000026_abnormal_inner_ear0.88404345
90MP0000015_abnormal_ear_pigmentation0.88233930
91MP0008260_abnormal_autophagy0.87043343
92MP0004924_abnormal_behavior0.86482482
93MP0005386_behavior/neurological_phenoty0.86482482
94MP0002160_abnormal_reproductive_system0.85920694
95MP0000230_abnormal_systemic_arterial0.84438432
96* MP0002184_abnormal_innervation0.83509792
97* MP0009745_abnormal_behavioral_response0.83379515
98MP0003938_abnormal_ear_development0.83289694
99MP0002735_abnormal_chemical_nociception0.82548437
100MP0002067_abnormal_sensory_capabilities0.81721417
101MP0005448_abnormal_energy_balance0.80233800
102MP0001501_abnormal_sleep_pattern0.80023916
103MP0000579_abnormal_nail_morphology0.79883367
104MP0001765_abnormal_ion_homeostasis0.79768636
105MP0005319_abnormal_enzyme/_coenzyme0.79521695
106MP0005395_other_phenotype0.79439190
107MP0002132_abnormal_respiratory_system0.79352511
108MP0004145_abnormal_muscle_electrophysio0.79231487
109* MP0002752_abnormal_somatic_nervous0.79221006
110MP0006072_abnormal_retinal_apoptosis0.78409595
111MP0003191_abnormal_cellular_cholesterol0.77283464
112MP0002572_abnormal_emotion/affect_behav0.76967430
113MP0002751_abnormal_autonomic_nervous0.76963220
114MP0004043_abnormal_pH_regulation0.76731265
115MP0002249_abnormal_larynx_morphology0.76480951
116MP0002069_abnormal_eating/drinking_beha0.75498575
117MP0001919_abnormal_reproductive_system0.75464327
118MP0001986_abnormal_taste_sensitivity0.75312068
119MP0005171_absent_coat_pigmentation0.74879165
120MP0001905_abnormal_dopamine_level0.74251216
121MP0002822_catalepsy0.73303949
122MP0002152_abnormal_brain_morphology0.72657479
123* MP0003879_abnormal_hair_cell0.71960815
124MP0002557_abnormal_social/conspecific_i0.71758671
125MP0003121_genomic_imprinting0.71625360
126* MP0002272_abnormal_nervous_system0.70571552
127* MP0001963_abnormal_hearing_physiology0.69366116
128MP0005187_abnormal_penis_morphology0.68513594
129MP0005584_abnormal_enzyme/coenzyme_acti0.67307726
130MP0003724_increased_susceptibility_to0.67168435
131MP0005535_abnormal_body_temperature0.66375993
132MP0003690_abnormal_glial_cell0.65691444
133MP0005084_abnormal_gallbladder_morpholo0.64273812
134MP0005248_abnormal_Harderian_gland0.62476316
135MP0000778_abnormal_nervous_system0.60903471
136MP0002168_other_aberrant_phenotype0.59495910
137MP0002734_abnormal_mechanical_nocicepti0.59032548
138MP0010386_abnormal_urinary_bladder0.58802395
139MP0001346_abnormal_lacrimal_gland0.58720061
140MP0001529_abnormal_vocalization0.58561240
141MP0009765_abnormal_xenobiotic_induced0.58444312
142MP0000631_abnormal_neuroendocrine_gland0.58391404
143MP0005636_abnormal_mineral_homeostasis0.58025786
144* MP0002064_seizures0.57130828
145MP0004742_abnormal_vestibular_system0.56350521
146MP0005253_abnormal_eye_physiology0.55160126
147MP0009763_increased_sensitivity_to0.54619706
148MP0009642_abnormal_blood_homeostasis0.54118996
149MP0005389_reproductive_system_phenotype0.52473420
150MP0003186_abnormal_redox_activity0.50659720

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)6.27047407
2Intrahepatic cholestasis (HP:0001406)5.61347623
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.03385367
4Joint hemorrhage (HP:0005261)4.82648604
5Deep venous thrombosis (HP:0002625)4.32622153
6Conjugated hyperbilirubinemia (HP:0002908)4.23530744
7Abnormality of monocarboxylic acid metabolism (HP:0010996)4.12401414
8Polyphagia (HP:0002591)3.96844027
9Hypobetalipoproteinemia (HP:0003563)3.80990040
10Confusion (HP:0001289)3.78907355
11Hydroxyprolinuria (HP:0003080)3.68853405
12Abnormality of proline metabolism (HP:0010907)3.68853405
13Xanthomatosis (HP:0000991)3.66018705
14Epidermoid cyst (HP:0200040)3.58472024
15Complement deficiency (HP:0004431)3.55730839
16Renal cortical cysts (HP:0000803)3.53902399
17Hyperlipoproteinemia (HP:0010980)3.53565147
18Genetic anticipation (HP:0003743)3.43984873
19Abnormality of vitamin B metabolism (HP:0004340)3.41717505
20Vascular calcification (HP:0004934)3.41103096
21Abnormality of methionine metabolism (HP:0010901)3.40782275
22Abnormality of the vitamin B12 metabolism (HP:0004341)3.34453132
23Osteomalacia (HP:0002749)3.32183527
24Nephronophthisis (HP:0000090)3.21046155
25True hermaphroditism (HP:0010459)3.13781478
26Hyperglycinemia (HP:0002154)3.08680366
27Abnormality of aspartate family amino acid metabolism (HP:0010899)3.03359715
28Fat malabsorption (HP:0002630)2.99642604
29Hypochromic microcytic anemia (HP:0004840)2.97442184
30Abnormality of pyrimidine metabolism (HP:0004353)2.97413692
31Pancreatic cysts (HP:0001737)2.96376251
32Hypophosphatemic rickets (HP:0004912)2.96033427
33Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.93570393
34Degeneration of the lateral corticospinal tracts (HP:0002314)2.93570393
35Molar tooth sign on MRI (HP:0002419)2.92736216
36Abnormality of midbrain morphology (HP:0002418)2.92736216
37Abnormal eating behavior (HP:0100738)2.90162748
38Fibular aplasia (HP:0002990)2.89211435
39Agitation (HP:0000713)2.88849019
40Pancreatic fibrosis (HP:0100732)2.84593452
41Abnormality of the corticospinal tract (HP:0002492)2.84109305
42Enlarged kidneys (HP:0000105)2.84061285
43Cardiovascular calcification (HP:0011915)2.81441401
443-Methylglutaconic aciduria (HP:0003535)2.77824364
45Hypolipoproteinemia (HP:0010981)2.76795990
46Progressive cerebellar ataxia (HP:0002073)2.75349385
47Chorioretinal atrophy (HP:0000533)2.74353392
48Abnormal ciliary motility (HP:0012262)2.73002641
49Rhinitis (HP:0012384)2.72508546
50Abnormality of the common coagulation pathway (HP:0010990)2.69879166
51Medial flaring of the eyebrow (HP:0010747)2.64679561
52Fair hair (HP:0002286)2.64434397
53Abnormality of the renal medulla (HP:0100957)2.64245999
54Decreased circulating renin level (HP:0003351)2.64094240
55Proximal tubulopathy (HP:0000114)2.63832467
56Action tremor (HP:0002345)2.62631171
57Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.58733317
58Synostosis involving the elbow (HP:0003938)2.56814174
59Humeroradial synostosis (HP:0003041)2.56814174
60Tubulointerstitial nephritis (HP:0001970)2.52995381
61Abnormality of sulfur amino acid metabolism (HP:0004339)2.52993935
62Rickets (HP:0002748)2.52954854
63Hyperglycinuria (HP:0003108)2.50606015
64Hypoalphalipoproteinemia (HP:0003233)2.47688979
65Aplasia/Hypoplasia of the tibia (HP:0005772)2.45946428
66Abnormality of vitamin metabolism (HP:0100508)2.45576168
67Chronic hepatic failure (HP:0100626)2.45570855
68Abnormality of complement system (HP:0005339)2.45112091
69Gait imbalance (HP:0002141)2.43352895
70Bile duct proliferation (HP:0001408)2.42556982
71Abnormal biliary tract physiology (HP:0012439)2.42556982
72Short tibia (HP:0005736)2.41441354
73Hyperammonemia (HP:0001987)2.40262332
74Abnormality of glycine metabolism (HP:0010895)2.40206923
75Abnormality of serine family amino acid metabolism (HP:0010894)2.40206923
76Abnormal respiratory motile cilium physiology (HP:0012261)2.34896794
77Hip dysplasia (HP:0001385)2.34435110
78Hyperventilation (HP:0002883)2.33347893
79Parakeratosis (HP:0001036)2.32279917
80Cystic liver disease (HP:0006706)2.32276932
81Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.30258876
82Decreased central vision (HP:0007663)2.29641067
83Hypercholesterolemia (HP:0003124)2.29558367
84Broad-based gait (HP:0002136)2.28603590
85Ketosis (HP:0001946)2.27690327
86Abolished electroretinogram (ERG) (HP:0000550)2.27062013
87Steatorrhea (HP:0002570)2.25779162
88Abnormality of serum amino acid levels (HP:0003112)2.25485804
89Abnormality of the intrinsic pathway (HP:0010989)2.25134859
90Abnormality of glutamine family amino acid metabolism (HP:0010902)2.24629310
91Hyperbilirubinemia (HP:0002904)2.23422833
92Symphalangism affecting the phalanges of the hand (HP:0009773)2.23236788
93Hypoglycemic coma (HP:0001325)2.20161104
94Rib fusion (HP:0000902)2.18525130
95Congenital primary aphakia (HP:0007707)2.17755894
96Pigmentary retinal degeneration (HP:0001146)2.17495685
97Amyloidosis (HP:0011034)2.17431031
98Metabolic alkalosis (HP:0200114)2.15227518
99Hyperphosphaturia (HP:0003109)2.13463696
100Prolonged neonatal jaundice (HP:0006579)2.12539471
101Febrile seizures (HP:0002373)2.11616605
102Delayed CNS myelination (HP:0002188)2.11303475
103Hepatoblastoma (HP:0002884)2.10861074
104Metabolic acidosis (HP:0001942)2.10133343
105Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.08040826
106Myokymia (HP:0002411)2.05996550
107Abnormality of the middle phalanges of the toes (HP:0010183)2.02368520
108Limb dystonia (HP:0002451)2.02183312
109Nephrogenic diabetes insipidus (HP:0009806)2.01824209
110Abnormality of renal resorption (HP:0011038)2.00345644
111Abnormality of urine glucose concentration (HP:0011016)2.00138256
112Glycosuria (HP:0003076)2.00138256
113Systemic lupus erythematosus (HP:0002725)1.99735226
114Widely patent fontanelles and sutures (HP:0004492)1.99341320
115Dynein arm defect of respiratory motile cilia (HP:0012255)1.97888686
116Absent/shortened dynein arms (HP:0200106)1.97888686
117Abnormality of the proximal phalanges of the hand (HP:0009834)1.96561462
118Renal Fanconi syndrome (HP:0001994)1.95825526
119Abnormality of secondary sexual hair (HP:0009888)1.95510152
120Abnormality of the axillary hair (HP:0100134)1.95510152
121Reduced antithrombin III activity (HP:0001976)1.95427325
122Aplasia/Hypoplasia of the fibula (HP:0006492)1.94450249
123Mitral stenosis (HP:0001718)1.94332254
124Abnormality of the renal cortex (HP:0011035)1.92832474
125Recurrent gram-negative bacterial infections (HP:0005420)1.92771760
126Chromosomal breakage induced by crosslinking agents (HP:0003221)1.92600467
127Ulnar claw (HP:0001178)1.91612326
128Blue irides (HP:0000635)1.90980235
129Abnormality of nucleobase metabolism (HP:0010932)1.90282795
130Aplasia/Hypoplasia of the ulna (HP:0006495)1.89139072
131Gingival bleeding (HP:0000225)1.88315173
132Generalized hypopigmentation of hair (HP:0011358)1.86971667
133Vaginal atresia (HP:0000148)1.85886523
134Opisthotonus (HP:0002179)1.85062333
135Genital tract atresia (HP:0001827)1.85004652
136Renal tubular dysfunction (HP:0000124)1.84891216
137Hypoglycemic seizures (HP:0002173)1.84819953
138Hemiparesis (HP:0001269)1.83532094
139Impaired vibration sensation in the lower limbs (HP:0002166)1.83046827
140Adactyly (HP:0009776)1.82709099
141Hypoplasia of the ulna (HP:0003022)1.81755740
142Abnormal respiratory epithelium morphology (HP:0012253)1.81531497
143Abnormal respiratory motile cilium morphology (HP:0005938)1.81531497
144Alveolar cell carcinoma (HP:0006519)1.81183220
145Megaloblastic anemia (HP:0001889)1.80926702
146Chronic diarrhea (HP:0002028)1.80626128
147Abnormality of the 1st metacarpal (HP:0010009)1.80371707
148Anencephaly (HP:0002323)1.80358540
149Specific learning disability (HP:0001328)1.79718051
150Lethargy (HP:0001254)1.79137028
151Sclerocornea (HP:0000647)1.78801337
152Postaxial hand polydactyly (HP:0001162)1.78657833
153Focal motor seizures (HP:0011153)1.78167156
154Hepatocellular carcinoma (HP:0001402)1.77989485
155Hypothermia (HP:0002045)1.77911797
156Malnutrition (HP:0004395)1.77450578
157Glomerulonephritis (HP:0000099)1.77254509
158Abnormal urine phosphate concentration (HP:0012599)1.77250444
159Menorrhagia (HP:0000132)1.75055420
160Abnormality of fatty-acid metabolism (HP:0004359)1.74926456
161Methylmalonic acidemia (HP:0002912)1.74740130
162Status epilepticus (HP:0002133)1.73895170
163Cerebral edema (HP:0002181)1.73888218
164Alkalosis (HP:0001948)1.73725778
165Spontaneous abortion (HP:0005268)1.73403792
166Poor coordination (HP:0002370)1.73205778
167Nephrolithiasis (HP:0000787)1.72460297
168Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.72440184
169Congenital sensorineural hearing impairment (HP:0008527)1.72387099
170Occipital encephalocele (HP:0002085)1.71487551
171Methylmalonic aciduria (HP:0012120)1.70954624
172Elevated alkaline phosphatase (HP:0003155)1.70766545
173Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.70157710
174Short 1st metacarpal (HP:0010034)1.70157710
175Septo-optic dysplasia (HP:0100842)1.69353866

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.65117100
2MAP3K43.46016563
3INSRR3.18798426
4ACVR1B2.90249555
5STK162.77481574
6TNIK2.56973310
7IRAK32.46013248
8MUSK2.44213407
9ZAK2.17862972
10YES12.08865280
11IRAK42.03381151
12BLK1.98518491
13TAOK31.88676564
14MKNK21.82232128
15GRK11.76331285
16WNK41.75011734
17IRAK11.67867695
18PIK3CG1.67274691
19IRAK21.66359224
20ADRBK21.66241702
21BMPR21.63908330
22MAP3K141.63628784
23DYRK31.60307583
24PINK11.57015010
25MAP2K71.56778962
26MAPK151.53832703
27FGFR41.49455977
28GRK71.45597686
29MARK11.43063959
30EIF2AK21.42105670
31MAPK131.40175700
32NTRK31.34032229
33TXK1.33610283
34PKN11.33034423
35BCKDK1.24228375
36MAP4K21.20595046
37DYRK1B1.19740768
38SIK31.17938868
39EPHA31.15116076
40EPHA41.14137246
41BMPR1B1.13074271
42ERBB41.07475819
43EPHB21.05824597
44FLT31.04557164
45PKN21.04525928
46TNK21.04006491
47CDK31.03704087
48PRPF4B1.01158195
49PRKG21.00327101
50MAP2K40.99980089
51WNK30.99739543
52SGK20.97960055
53CSNK1G10.96998608
54SIK10.96107114
55CSNK1A1L0.95739988
56CDK190.94822751
57MAPK40.92548951
58RPS6KA40.91255556
59NEK60.90786703
60CDK50.90308309
61PRKCZ0.87929635
62ERBB30.87736277
63SRPK10.85420320
64CSNK1G30.84337514
65CSNK1G20.79306375
66ERBB20.78543976
67MAPK70.78436085
68DYRK1A0.77302444
69SGK4940.77146637
70SGK2230.77146637
71UHMK10.77012965
72CAMK2A0.76540636
73STK38L0.76503105
74NTRK20.75070222
75MAPKAPK30.74429841
76PAK30.74043893
77AKT30.72065231
78MKNK10.71722806
79SIK20.71589488
80PNCK0.70815548
81TYRO30.69989243
82MST1R0.69302503
83CAMK2G0.69153846
84CAMK2B0.65539484
85TAOK10.65530112
86PBK0.65461383
87PRKCG0.65293983
88PRKCE0.63219195
89PRKCQ0.63196506
90MAP3K90.62814302
91TAOK20.61722668
92TEC0.60654000
93FES0.60460619
94CAMK2D0.60147178
95PRKACG0.57864684
96EPHB10.57135759
97PRKAA20.56259230
98OXSR10.55782608
99TGFBR20.55408271
100NTRK10.54247167
101BCR0.54035516
102DYRK20.54034801
103GRK50.53492881
104STK390.52935161
105CSK0.52529960
106PAK60.52280401
107CSNK1A10.49993512
108ROCK10.49926129
109PIK3CA0.49736044
110PRKACA0.49503532
111ABL20.49306137
112LYN0.48912490
113DAPK20.48480441
114PRKG10.46136755
115STK240.45908072
116MAP2K60.44998611
117MAPK110.44982425
118MAP3K130.44856725
119FGR0.44834339
120RPS6KA20.44786582
121NLK0.43284739
122JAK10.43238796
123CAMK10.42968062
124NUAK10.42697971
125MAP3K100.42421262
126IKBKE0.41323193
127MAP3K120.41281714
128SGK10.41266831
129PRKCA0.40655796
130PLK40.39732678
131MAPK120.39361521
132FRK0.38672988
133TIE10.38644788
134HCK0.38491542
135ADRBK10.37982679
136PTK2B0.36611875
137FYN0.36560600
138PLK20.34693425
139TGFBR10.31705136
140GSK3A0.29911264
141TLK10.29312319
142PRKAA10.28942621
143PRKACB0.27891737
144PRKD20.26765958
145PRKCB0.25832128
146SGK30.25385976
147RPS6KA60.24902520
148CDK11A0.23561068

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.33444856
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.49392919
3Renin-angiotensin system_Homo sapiens_hsa046142.74163594
4Tryptophan metabolism_Homo sapiens_hsa003802.66015347
5Fatty acid elongation_Homo sapiens_hsa000622.63162704
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.61299200
7Steroid hormone biosynthesis_Homo sapiens_hsa001402.52881211
8Complement and coagulation cascades_Homo sapiens_hsa046102.50567018
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.36762633
10Retinol metabolism_Homo sapiens_hsa008302.36573902
11Histidine metabolism_Homo sapiens_hsa003402.35261875
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.24257711
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.16088740
14Peroxisome_Homo sapiens_hsa041462.15906281
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.12887412
16Butanoate metabolism_Homo sapiens_hsa006502.12318684
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.07500339
18Protein digestion and absorption_Homo sapiens_hsa049742.05935910
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.03150455
20beta-Alanine metabolism_Homo sapiens_hsa004102.02830427
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.01675236
22Mineral absorption_Homo sapiens_hsa049781.97965732
23Chemical carcinogenesis_Homo sapiens_hsa052041.95500403
24Fatty acid degradation_Homo sapiens_hsa000711.86265342
25Arginine biosynthesis_Homo sapiens_hsa002201.85701479
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.82087545
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.80698594
28Steroid biosynthesis_Homo sapiens_hsa001001.72491758
29Cocaine addiction_Homo sapiens_hsa050301.72359171
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.72004512
31ABC transporters_Homo sapiens_hsa020101.70962958
32Staphylococcus aureus infection_Homo sapiens_hsa051501.68977118
33Phenylalanine metabolism_Homo sapiens_hsa003601.66554599
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.65367148
35Tyrosine metabolism_Homo sapiens_hsa003501.63239452
36Carbohydrate digestion and absorption_Homo sapiens_hsa049731.62387962
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.50090215
38Sulfur metabolism_Homo sapiens_hsa009201.48637577
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.47473671
40Fatty acid metabolism_Homo sapiens_hsa012121.46095797
41PPAR signaling pathway_Homo sapiens_hsa033201.46017112
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45598428
43Nitrogen metabolism_Homo sapiens_hsa009101.45519796
44Galactose metabolism_Homo sapiens_hsa000521.45258048
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.30113474
46Propanoate metabolism_Homo sapiens_hsa006401.30092103
47Parkinsons disease_Homo sapiens_hsa050121.28797781
48Insulin secretion_Homo sapiens_hsa049111.27169465
49Vitamin B6 metabolism_Homo sapiens_hsa007501.26664677
50Vitamin digestion and absorption_Homo sapiens_hsa049771.17590286
51Starch and sucrose metabolism_Homo sapiens_hsa005001.14155583
52Amphetamine addiction_Homo sapiens_hsa050311.13040518
53Bile secretion_Homo sapiens_hsa049761.04119586
54Dopaminergic synapse_Homo sapiens_hsa047281.01303080
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00926855
56Fructose and mannose metabolism_Homo sapiens_hsa000511.00356143
57Arginine and proline metabolism_Homo sapiens_hsa003300.99658142
58* Nicotine addiction_Homo sapiens_hsa050330.98283126
59Selenocompound metabolism_Homo sapiens_hsa004500.94145931
60Alzheimers disease_Homo sapiens_hsa050100.94145186
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91968691
62Huntingtons disease_Homo sapiens_hsa050160.91333876
63Phototransduction_Homo sapiens_hsa047440.90472203
64Circadian entrainment_Homo sapiens_hsa047130.90174204
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88248130
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86695977
67Axon guidance_Homo sapiens_hsa043600.84769386
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82684848
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82632645
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82576918
71Fat digestion and absorption_Homo sapiens_hsa049750.80989542
72Cardiac muscle contraction_Homo sapiens_hsa042600.79413791
73Folate biosynthesis_Homo sapiens_hsa007900.72424344
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69959436
75Caffeine metabolism_Homo sapiens_hsa002320.65310634
76Cholinergic synapse_Homo sapiens_hsa047250.64987021
77Pyruvate metabolism_Homo sapiens_hsa006200.64159760
78Metabolic pathways_Homo sapiens_hsa011000.63500959
79Linoleic acid metabolism_Homo sapiens_hsa005910.63162419
80Arachidonic acid metabolism_Homo sapiens_hsa005900.58021132
81Lysine degradation_Homo sapiens_hsa003100.57783220
82Regulation of autophagy_Homo sapiens_hsa041400.55395642
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54815335
84Glycerolipid metabolism_Homo sapiens_hsa005610.54670878
85Ovarian steroidogenesis_Homo sapiens_hsa049130.54616529
86Renin secretion_Homo sapiens_hsa049240.51562600
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.49446209
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49119393
89Taste transduction_Homo sapiens_hsa047420.46854545
90Fatty acid biosynthesis_Homo sapiens_hsa000610.46695800
91Basal cell carcinoma_Homo sapiens_hsa052170.46590174
92Hedgehog signaling pathway_Homo sapiens_hsa043400.46093301
93Glutathione metabolism_Homo sapiens_hsa004800.43792325
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41839158
95Type II diabetes mellitus_Homo sapiens_hsa049300.41465001
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40712028
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.40229396
98Ether lipid metabolism_Homo sapiens_hsa005650.40058427
99Thyroid hormone synthesis_Homo sapiens_hsa049180.39679020
100Autoimmune thyroid disease_Homo sapiens_hsa053200.39598861
101Gap junction_Homo sapiens_hsa045400.39275626
102Serotonergic synapse_Homo sapiens_hsa047260.38858549
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38565803
104Morphine addiction_Homo sapiens_hsa050320.37944877
105Olfactory transduction_Homo sapiens_hsa047400.37830947
106GABAergic synapse_Homo sapiens_hsa047270.37123690
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36675766
108cAMP signaling pathway_Homo sapiens_hsa040240.33963017
109Sphingolipid metabolism_Homo sapiens_hsa006000.33590245
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.31194668
111Pancreatic secretion_Homo sapiens_hsa049720.30317211
112Notch signaling pathway_Homo sapiens_hsa043300.29399009
113Gastric acid secretion_Homo sapiens_hsa049710.29174045
114Prion diseases_Homo sapiens_hsa050200.28787323
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28518071
116Graft-versus-host disease_Homo sapiens_hsa053320.27946984
117* Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.26940116
118One carbon pool by folate_Homo sapiens_hsa006700.26796573
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.26445904
120African trypanosomiasis_Homo sapiens_hsa051430.26184163
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.23699007
122Sulfur relay system_Homo sapiens_hsa041220.20881575
123* Glutamatergic synapse_Homo sapiens_hsa047240.20315549
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.20009281
125Intestinal immune network for IgA production_Homo sapiens_hsa046720.17180226
126Oxidative phosphorylation_Homo sapiens_hsa001900.13938092
127Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.12797177
128Allograft rejection_Homo sapiens_hsa053300.10170100
129Protein export_Homo sapiens_hsa030600.10094087
130NF-kappa B signaling pathway_Homo sapiens_hsa040640.09799334
131Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.08622137
132Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.08250373
133Calcium signaling pathway_Homo sapiens_hsa040200.05040760

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