SLC17A9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of transmembrane proteins that are involved in the transport of small molecules. The encoded protein participates in the vesicular uptake, storage, and secretion of adenoside triphosphate (ATP) and other nucleotides. A mutation in this gene was found in individuals with autosomal dominant disseminated superficial actinic porokeratosis-8. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of fibrinolysis (GO:0051918)6.82646168
2protein carboxylation (GO:0018214)6.41274993
3peptidyl-glutamic acid carboxylation (GO:0017187)6.41274993
4regulation of fibrinolysis (GO:0051917)6.02278295
5low-density lipoprotein particle remodeling (GO:0034374)5.85847008
6plasma lipoprotein particle assembly (GO:0034377)5.70442131
7plasma lipoprotein particle remodeling (GO:0034369)5.53875510
8protein-lipid complex remodeling (GO:0034368)5.53875510
9macromolecular complex remodeling (GO:0034367)5.53875510
10very-low-density lipoprotein particle assembly (GO:0034379)5.50391201
11regulation of protein activation cascade (GO:2000257)5.41954275
12regulation of cholesterol esterification (GO:0010872)5.34747052
13regulation of complement activation (GO:0030449)5.31089783
14protein-lipid complex assembly (GO:0065005)5.12025209
15regulation of apoptotic cell clearance (GO:2000425)5.10342647
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.07985993
17complement activation, alternative pathway (GO:0006957)5.02189158
18plasma lipoprotein particle organization (GO:0071827)4.99137923
19cholesterol efflux (GO:0033344)4.94853091
20regulation of plasminogen activation (GO:0010755)4.94760890
21intestinal cholesterol absorption (GO:0030299)4.92865702
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.92110753
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.92110753
24DNA deamination (GO:0045006)4.84858442
25pinocytosis (GO:0006907)4.76097960
26high-density lipoprotein particle remodeling (GO:0034375)4.75914259
27protein-lipid complex subunit organization (GO:0071825)4.71595615
28negative regulation of sterol transport (GO:0032372)4.52400738
29negative regulation of cholesterol transport (GO:0032375)4.52400738
30positive regulation of fatty acid biosynthetic process (GO:0045723)4.50814904
31ribosomal small subunit assembly (GO:0000028)4.37925295
32plasma lipoprotein particle clearance (GO:0034381)4.37641877
33positive regulation of gamma-delta T cell activation (GO:0046645)4.35913047
34blood coagulation, intrinsic pathway (GO:0007597)4.32549636
35reverse cholesterol transport (GO:0043691)4.26538587
36L-phenylalanine catabolic process (GO:0006559)4.23843177
37erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.23843177
38regulation of gamma-delta T cell differentiation (GO:0045586)4.18336509
39antigen processing and presentation of endogenous antigen (GO:0019883)4.17186565
40regulation of cholesterol homeostasis (GO:2000188)4.12403448
41positive regulation of lipoprotein lipase activity (GO:0051006)4.02688415
42positive regulation of triglyceride lipase activity (GO:0061365)4.02688415
43phospholipid efflux (GO:0033700)4.00716728
44L-phenylalanine metabolic process (GO:0006558)4.00259045
45erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.00259045
46positive regulation of extracellular matrix organization (GO:1903055)3.88349366
47acute-phase response (GO:0006953)3.87395991
48fibrinolysis (GO:0042730)3.83931105
49regulation of gamma-delta T cell activation (GO:0046643)3.76940385
50regulation of humoral immune response (GO:0002920)3.57496514
51regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.56808609
52positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.52393289
53protein activation cascade (GO:0072376)3.51570759
54imidazole-containing compound metabolic process (GO:0052803)3.49950472
55leukocyte aggregation (GO:0070486)3.47855131
56negative regulation of hemostasis (GO:1900047)3.46971899
57negative regulation of blood coagulation (GO:0030195)3.46971899
58positive regulation of hemostasis (GO:1900048)3.46380709
59positive regulation of blood coagulation (GO:0030194)3.46380709
60lipoprotein metabolic process (GO:0042157)3.43800883
61complement activation, classical pathway (GO:0006958)3.40981467
62interferon-gamma production (GO:0032609)3.40181155
63positive regulation of phagocytosis (GO:0050766)3.36391512
64viral transcription (GO:0019083)3.31022465
65SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.29769365
66intestinal absorption (GO:0050892)3.25641301
67glutamate metabolic process (GO:0006536)3.22785121
68negative regulation of protein activation cascade (GO:2000258)3.22709585
69low-density lipoprotein particle clearance (GO:0034383)3.22546773
70regulation of cholesterol biosynthetic process (GO:0045540)3.19854950
71negative regulation of myeloid cell apoptotic process (GO:0033033)3.19521590
72regulation of superoxide anion generation (GO:0032928)3.18715133
73protein targeting to ER (GO:0045047)3.18415703
74cotranslational protein targeting to membrane (GO:0006613)3.16511041
75folic acid-containing compound biosynthetic process (GO:0009396)3.14976138
76negative regulation of coagulation (GO:0050819)3.12937504
77IMP biosynthetic process (GO:0006188)3.12671157
78cholesterol homeostasis (GO:0042632)3.10769125
79regulation of fatty acid biosynthetic process (GO:0042304)3.10653729
80translational termination (GO:0006415)3.10476074
81positive regulation of coagulation (GO:0050820)3.10364091
82telomere maintenance via semi-conservative replication (GO:0032201)3.09091382
83complement activation (GO:0006956)3.08219292
84sterol homeostasis (GO:0055092)3.07496403
85regulation of B cell differentiation (GO:0045577)3.06941509
86cholesterol transport (GO:0030301)3.05002300
87sterol transport (GO:0015918)3.05002300
88regulation of phagocytosis (GO:0050764)3.03313374
89urea cycle (GO:0000050)3.01606480
90mannose metabolic process (GO:0006013)3.00975020
91urea metabolic process (GO:0019627)2.99905975
92establishment of protein localization to endoplasmic reticulum (GO:0072599)2.98933049
93proline biosynthetic process (GO:0006561)2.98914076
94disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.98757891
95killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.98757891
96ribosomal small subunit biogenesis (GO:0042274)2.98654400
97regulation of extracellular matrix organization (GO:1903053)2.98321270
98antigen processing and presentation via MHC class Ib (GO:0002475)2.98302379
99protein localization to endoplasmic reticulum (GO:0070972)2.98125217
100diacylglycerol metabolic process (GO:0046339)2.94439880
101Golgi transport vesicle coating (GO:0048200)2.92874172
102COPI coating of Golgi vesicle (GO:0048205)2.92874172
103positive regulation of steroid metabolic process (GO:0045940)2.91383431
104negative regulation of wound healing (GO:0061045)2.91051934
105regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.91046733
106signal peptide processing (GO:0006465)2.90219454
107regulation of bile acid biosynthetic process (GO:0070857)2.89999085
108translational elongation (GO:0006414)2.89692700
109positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.89658018
110acylglycerol homeostasis (GO:0055090)2.87460850
111triglyceride homeostasis (GO:0070328)2.87460850
112response to interleukin-15 (GO:0070672)2.87138335
113acute inflammatory response (GO:0002526)2.85553371
114positive thymic T cell selection (GO:0045059)2.83946744
115oligosaccharide catabolic process (GO:0009313)2.83496968
116positive regulation of B cell differentiation (GO:0045579)2.83157068
117regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.81408574
118negative regulation of digestive system process (GO:0060457)2.80106514
119DNA strand elongation involved in DNA replication (GO:0006271)2.78788921
120formation of translation preinitiation complex (GO:0001731)2.77923618
121pteridine-containing compound biosynthetic process (GO:0042559)2.76190413
122negative thymic T cell selection (GO:0045060)2.73998198
123nitrogen cycle metabolic process (GO:0071941)2.72348786
124DNA strand elongation (GO:0022616)2.71985214
125negative T cell selection (GO:0043383)2.71702554
126cellular response to interleukin-15 (GO:0071350)2.68898325
127IMP metabolic process (GO:0046040)2.67930651
128GDP-mannose metabolic process (GO:0019673)2.66435503
129regulation of B cell receptor signaling pathway (GO:0050855)2.64481240
130ribosome biogenesis (GO:0042254)2.63768620
131negative regulation of lipid transport (GO:0032369)2.62255598
132NIK/NF-kappaB signaling (GO:0038061)2.60711364
133ribonucleoprotein complex biogenesis (GO:0022613)2.60037369
134regulation of lipoprotein particle clearance (GO:0010984)2.59040718
135telomere maintenance via recombination (GO:0000722)2.57856713
136regulation of cholesterol storage (GO:0010885)2.56969468
137regulation of monocyte differentiation (GO:0045655)2.55865653
138negative regulation of complement activation (GO:0045916)2.55833260
139maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.55689648
140mast cell activation (GO:0045576)2.55227069
141negative regulation of phagocytosis (GO:0050765)2.54479399
142cellular response to interleukin-4 (GO:0071353)2.54041362
143glyoxylate metabolic process (GO:0046487)2.52865799
144protein retention in ER lumen (GO:0006621)2.52624834
145hyaluronan metabolic process (GO:0030212)2.52295185
146nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.51899442
147regulation of T cell receptor signaling pathway (GO:0050856)2.51196631
148regulation of cholesterol metabolic process (GO:0090181)2.50849576
149negative regulation of humoral immune response (GO:0002921)2.50489837
150translational initiation (GO:0006413)2.50043142
151aromatic amino acid family catabolic process (GO:0009074)2.48442098
152negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.46965120
153lipid homeostasis (GO:0055088)2.46864092
154immunoglobulin mediated immune response (GO:0016064)2.45689168
155positive regulation of chemokine secretion (GO:0090197)2.44770522
156negative regulation of cell killing (GO:0031342)2.44301929
157negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.44301929
158viral life cycle (GO:0019058)2.42770637
159thymic T cell selection (GO:0045061)2.42057048
160pseudouridine synthesis (GO:0001522)2.41593283
161ribosomal large subunit biogenesis (GO:0042273)2.38650425
162T cell migration (GO:0072678)2.37314311
163regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.37073812
164maturation of SSU-rRNA (GO:0030490)2.36512331
165sequestering of actin monomers (GO:0042989)2.35562863
166regulation of necroptotic process (GO:0060544)2.34794500
167regulation of interleukin-12 biosynthetic process (GO:0045075)2.34651312
168cellular response to interferon-beta (GO:0035458)2.32696376
169B cell receptor signaling pathway (GO:0050853)2.32533006
170somatic diversification of immune receptors via somatic mutation (GO:0002566)2.31038551
171somatic hypermutation of immunoglobulin genes (GO:0016446)2.31038551
172negative regulation of interleukin-12 production (GO:0032695)2.28125827
173telomere maintenance via telomere lengthening (GO:0010833)2.28037312
174mitotic recombination (GO:0006312)2.27538578
175antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.27475640
176natural killer cell activation (GO:0030101)2.27271806
177proline metabolic process (GO:0006560)2.26841369
178B cell mediated immunity (GO:0019724)2.25523597
179DNA replication initiation (GO:0006270)2.25097805
180response to type I interferon (GO:0034340)2.24736541
181mature B cell differentiation involved in immune response (GO:0002313)2.24691648
182T cell homeostasis (GO:0043029)2.24686827
183T cell receptor signaling pathway (GO:0050852)2.24255098
184Arp2/3 complex-mediated actin nucleation (GO:0034314)2.23954597
185response to interferon-beta (GO:0035456)2.23702094
186positive regulation of protein deacetylation (GO:0090312)2.23023415
187regulation of translation in response to stress (GO:0043555)2.22774295
188DNA unwinding involved in DNA replication (GO:0006268)2.22025980
189antigen receptor-mediated signaling pathway (GO:0050851)2.21767878
190valine metabolic process (GO:0006573)2.21552164
191nuclear-transcribed mRNA catabolic process (GO:0000956)2.20975438
192cellular response to type I interferon (GO:0071357)2.20690028
193type I interferon signaling pathway (GO:0060337)2.20690028
194lymph node development (GO:0048535)2.20403122
195regulation of response to interferon-gamma (GO:0060330)2.19537493
196nucleobase biosynthetic process (GO:0046112)2.19152469
197cellular protein complex disassembly (GO:0043624)2.18864942

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.23424929
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.94379795
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.04549358
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.02985110
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.00122490
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.91798291
7* MYC_22102868_ChIP-Seq_BL_Human2.85705282
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.66467067
9SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.41708387
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.40617226
11* LXR_22292898_ChIP-Seq_THP-1_Human2.35414542
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.33056307
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.19824530
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.19351556
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.18295564
16VDR_21846776_ChIP-Seq_THP-1_Human2.10586166
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.10130169
18ZNF263_19887448_ChIP-Seq_K562_Human2.06362947
19LXR_22158963_ChIP-Seq_LIVER_Mouse2.06244788
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.05649795
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.03032314
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.99706336
23TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.97639923
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.96422033
25MYC_18358816_ChIP-ChIP_MESCs_Mouse1.94516952
26FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.91284162
27SCL_19346495_ChIP-Seq_HPC-7_Human1.88192124
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.84012030
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.83854538
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.83618319
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.81787646
32IRF8_21731497_ChIP-ChIP_J774_Mouse1.81329837
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.77852292
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.77618297
35* SPI1_23547873_ChIP-Seq_NB4_Human1.75298674
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.68187899
37MAF_26560356_Chip-Seq_TH1_Human1.68047556
38SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.66503569
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.65235904
40MYB_26560356_Chip-Seq_TH2_Human1.63237701
41* MYB_26560356_Chip-Seq_TH1_Human1.61955631
42UTX_26944678_Chip-Seq_JUKART_Human1.61502820
43FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.61313507
44VDR_23849224_ChIP-Seq_CD4+_Human1.60803892
45FOXA2_19822575_ChIP-Seq_HepG2_Human1.59768901
46GABP_17652178_ChIP-ChIP_JURKAT_Human1.59513822
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.58730888
48EST1_17652178_ChIP-ChIP_JURKAT_Human1.58556621
49RUNX1_22412390_ChIP-Seq_EML_Mouse1.58343287
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.58242771
51FOXP3_21729870_ChIP-Seq_TREG_Human1.56691128
52FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.56285514
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.56267864
54ETS1_20019798_ChIP-Seq_JURKAT_Human1.54869705
55* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51679033
56RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48712186
57* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.47923921
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47812519
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.47272436
60EGR1_23403033_ChIP-Seq_LIVER_Mouse1.44557673
61KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.43994356
62ELF1_20517297_ChIP-Seq_JURKAT_Human1.43907920
63FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.42780149
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.42277252
65* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41960275
66HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41073699
67IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40773739
68FOXM1_23109430_ChIP-Seq_U2OS_Human1.40726349
69CIITA_25753668_ChIP-Seq_RAJI_Human1.39071392
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38867760
71BP1_19119308_ChIP-ChIP_Hs578T_Human1.38640325
72VDR_24763502_ChIP-Seq_THP-1_Human1.36952855
73ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.36424335
74* P68_20966046_ChIP-Seq_HELA_Human1.35176537
75XRN2_22483619_ChIP-Seq_HELA_Human1.34636625
76E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32690290
77HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32609532
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32262230
79TCF7_22412390_ChIP-Seq_EML_Mouse1.31207393
80NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31040428
81RACK7_27058665_Chip-Seq_MCF-7_Human1.31020022
82GATA1_22383799_ChIP-Seq_G1ME_Mouse1.30896109
83KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.29780203
84KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.29780203
85KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.29780203
86RUNX_20019798_ChIP-Seq_JUKART_Human1.29224526
87* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29031519
88NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28493870
89MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.28116988
90HNF4A_19822575_ChIP-Seq_HepG2_Human1.27841989
91GABP_19822575_ChIP-Seq_HepG2_Human1.27622137
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.27296319
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26516994
94STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.26298738
95NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.25867123
96GATA1_19941827_ChIP-Seq_MEL_Mouse1.24367454
97NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23785345
98CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23430666
99* KDM2B_26808549_Chip-Seq_DND41_Human1.23289436
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22104136
101* MAF_26560356_Chip-Seq_TH2_Human1.21642499
102BCL6_27268052_Chip-Seq_Bcells_Human1.21327758
103BCOR_27268052_Chip-Seq_Bcells_Human1.20859100
104HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20784089
105DCP1A_22483619_ChIP-Seq_HELA_Human1.20186450
106PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18565257
107CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.18527237
108* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18401244
109SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.17327419
110STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17073805
111POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16398319
112TET1_21451524_ChIP-Seq_MESCs_Mouse1.15659029
113NCOR1_26117541_ChIP-Seq_K562_Human1.15482664
114KDM5A_27292631_Chip-Seq_BREAST_Human1.14825907
115TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14758857
116PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14527579
117CLOCK_20551151_ChIP-Seq_293T_Human1.14469151
118LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.13032032
119TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12826616
120SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11252668
121FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10358661
122POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10169588
123CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09277985
124CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08534201
125YY1_21170310_ChIP-Seq_MESCs_Mouse1.08020565
126CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.08004596
127GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07279480
128TFEB_21752829_ChIP-Seq_HELA_Human1.05968150
129MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05900590
130MYCN_18555785_ChIP-Seq_MESCs_Mouse1.05461890
131RXRA_24833708_ChIP-Seq_LIVER_Mouse1.04477292
132TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04403042
133SPI1_23127762_ChIP-Seq_K562_Human1.04312576
134E2F1_21310950_ChIP-Seq_MCF-7_Human1.04167294
135CREB1_15753290_ChIP-ChIP_HEK293T_Human1.02783662
136RARA_24833708_ChIP-Seq_LIVER_Mouse1.02490816
137* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.01473196
138SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01209349
139* SA1_27219007_Chip-Seq_ERYTHROID_Human1.01065958
140IRF8_27001747_Chip-Seq_BMDM_Mouse0.99939060
141ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99929668
142* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99848231
143SRF_21415370_ChIP-Seq_HL-1_Mouse0.99763640
144PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99070572
145TP53_22127205_ChIP-Seq_IMR90_Human0.98799581
146TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96724878
147VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96434129
148KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96220171
149* RARB_24833708_ChIP-Seq_LIVER_Mouse0.96156328
150* SMC4_20622854_ChIP-Seq_HELA_Human0.95416770
151PPARA_22158963_ChIP-Seq_LIVER_Mouse0.95305823

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.57213888
2MP0003763_abnormal_thymus_physiology3.48470676
3MP0002396_abnormal_hematopoietic_system3.30457587
4MP0003195_calcinosis2.93885039
5MP0005451_abnormal_body_composition2.85711992
6MP0005671_abnormal_response_to2.67712312
7MP0001835_abnormal_antigen_presentation2.66371570
8MP0010329_abnormal_lipoprotein_level2.63565812
9MP0008875_abnormal_xenobiotic_pharmacok2.54803795
10MP0000685_abnormal_immune_system2.53233130
11MP0003436_decreased_susceptibility_to2.48597404
12MP0001800_abnormal_humoral_immune2.44182857
13MP0003693_abnormal_embryo_hatching2.43967173
14MP0009785_altered_susceptibility_to2.32529745
15MP0008057_abnormal_DNA_replication2.32152603
16MP0000490_abnormal_crypts_of2.27373925
17MP0010155_abnormal_intestine_physiology2.19884961
18MP0002398_abnormal_bone_marrow2.18848136
19MP0002420_abnormal_adaptive_immunity2.10332332
20MP0001790_abnormal_immune_system2.08752028
21MP0005387_immune_system_phenotype2.08752028
22MP0001819_abnormal_immune_cell2.07472044
23MP0005025_abnormal_response_to2.06575834
24MP0002723_abnormal_immune_serum2.03616473
25MP0005000_abnormal_immune_tolerance2.03001834
26MP0002452_abnormal_antigen_presenting1.98235506
27MP0004264_abnormal_extraembryonic_tissu1.97850775
28MP0005075_abnormal_melanosome_morpholog1.95434541
29MP0000689_abnormal_spleen_morphology1.95211933
30MP0004957_abnormal_blastocyst_morpholog1.94998556
31MP0003866_abnormal_defecation1.92893855
32MP0002166_altered_tumor_susceptibility1.92411800
33MP0003122_maternal_imprinting1.87793906
34MP0009333_abnormal_splenocyte_physiolog1.87640588
35MP0000716_abnormal_immune_system1.87492071
36MP0002722_abnormal_immune_system1.87107834
37MP0002405_respiratory_system_inflammati1.84862136
38MP0001873_stomach_inflammation1.83954457
39MP0003806_abnormal_nucleotide_metabolis1.82808729
40MP0002089_abnormal_postnatal_growth/wei1.78767226
41MP0005464_abnormal_platelet_physiology1.74014761
42MP0002429_abnormal_blood_cell1.70655911
43MP0002419_abnormal_innate_immunity1.67328039
44MP0000703_abnormal_thymus_morphology1.63969668
45MP0002006_tumorigenesis1.62108990
46MP0004808_abnormal_hematopoietic_stem1.59602595
47MP0005365_abnormal_bile_salt1.55014806
48MP0001845_abnormal_inflammatory_respons1.54883240
49MP0010094_abnormal_chromosome_stability1.54865247
50MP0005397_hematopoietic_system_phenotyp1.50780600
51MP0001545_abnormal_hematopoietic_system1.50780600
52MP0002138_abnormal_hepatobiliary_system1.49632686
53MP0003300_gastrointestinal_ulcer1.48765022
54MP0003183_abnormal_peptide_metabolism1.47827761
55MP0003077_abnormal_cell_cycle1.44987911
56MP0010352_gastrointestinal_tract_polyps1.44358162
57MP0003656_abnormal_erythrocyte_physiolo1.40068404
58MP0002148_abnormal_hypersensitivity_rea1.37900392
59MP0008007_abnormal_cellular_replicative1.37270956
60MP0005174_abnormal_tail_pigmentation1.35305923
61MP0003111_abnormal_nucleus_morphology1.34969444
62MP0000858_altered_metastatic_potential1.34571706
63MP0003172_abnormal_lysosome_physiology1.32239546
64MP0002019_abnormal_tumor_incidence1.30699852
65MP0002118_abnormal_lipid_homeostasis1.30582851
66MP0001915_intracranial_hemorrhage1.30580934
67MP0008260_abnormal_autophagy1.29245192
68MP0001853_heart_inflammation1.28786244
69MP0000604_amyloidosis1.28565330
70MP0000465_gastrointestinal_hemorrhage1.28172488
71MP0008058_abnormal_DNA_repair1.27719002
72MP0006082_CNS_inflammation1.23307680
73MP0005220_abnormal_exocrine_pancreas1.19441602
74MP0008469_abnormal_protein_level1.18106207
75MP0005076_abnormal_cell_differentiation1.15445975
76MP0003191_abnormal_cellular_cholesterol1.14779302
77MP0009278_abnormal_bone_marrow1.14681573
78MP0000566_synostosis1.14356675
79MP0003724_increased_susceptibility_to1.13197088
80MP0004947_skin_inflammation1.10853683
81MP0005332_abnormal_amino_acid1.10286777
82MP0002877_abnormal_melanocyte_morpholog1.09757992
83MP0001764_abnormal_homeostasis1.09266494
84MP0001666_abnormal_nutrient_absorption1.07810599
85MP0003786_premature_aging1.07761800
86MP0002933_joint_inflammation1.07521768
87MP0000477_abnormal_intestine_morphology1.06775588
88MP0006054_spinal_hemorrhage1.02326222
89MP0002693_abnormal_pancreas_physiology1.01394236
90MP0003303_peritoneal_inflammation1.01284301
91MP0000609_abnormal_liver_physiology0.98195513
92MP0003075_altered_response_to0.95264089
93MP0003123_paternal_imprinting0.94148662
94MP0000313_abnormal_cell_death0.93359092
95MP0000350_abnormal_cell_proliferation0.92240619
96MP0003868_abnormal_feces_composition0.92044835
97MP0005085_abnormal_gallbladder_physiolo0.89891506
98MP0002928_abnormal_bile_duct0.89645872
99MP0005409_darkened_coat_color0.89567114
100MP0002998_abnormal_bone_remodeling0.89294206
101MP0005257_abnormal_intraocular_pressure0.89120416
102MP0005670_abnormal_white_adipose0.87873415
103MP0010368_abnormal_lymphatic_system0.85949419
104MP0001533_abnormal_skeleton_physiology0.85548948
105MP0009642_abnormal_blood_homeostasis0.85546130
106MP0010307_abnormal_tumor_latency0.84991464
107MP0009384_cardiac_valve_regurgitation0.84359015
108MP0002132_abnormal_respiratory_system0.84296506
109MP0003283_abnormal_digestive_organ0.84278332
110MP0000598_abnormal_liver_morphology0.84182226
111MP0009840_abnormal_foam_cell0.83064083
112MP0004185_abnormal_adipocyte_glucose0.82711870
113MP0003186_abnormal_redox_activity0.82488068
114MP0005310_abnormal_salivary_gland0.81850007
115MP0000371_diluted_coat_color0.81042897
116MP0005164_abnormal_response_to0.80738260
117MP0008438_abnormal_cutaneous_collagen0.79645587
118MP0005023_abnormal_wound_healing0.79243758
119MP0000003_abnormal_adipose_tissue0.78926561
120MP0001661_extended_life_span0.76806183
121MP0002139_abnormal_hepatobiliary_system0.76414351
122MP0009765_abnormal_xenobiotic_induced0.76257795
123MP0005584_abnormal_enzyme/coenzyme_acti0.75823488
124MP0009763_increased_sensitivity_to0.75741332
125MP0005408_hypopigmentation0.74217828
126MP0009643_abnormal_urine_homeostasis0.72910456
127MP0000249_abnormal_blood_vessel0.71736558
128MP0005666_abnormal_adipose_tissue0.71701722
129MP0003252_abnormal_bile_duct0.71382715
130MP0003566_abnormal_cell_adhesion0.68081736
131MP0001663_abnormal_digestive_system0.67221327
132MP0009115_abnormal_fat_cell0.67145326
133MP0005084_abnormal_gallbladder_morpholo0.66462775
134MP0002971_abnormal_brown_adipose0.65999079
135MP0005319_abnormal_enzyme/_coenzyme0.64452673
136MP0003448_altered_tumor_morphology0.64050602
137MP0002970_abnormal_white_adipose0.63820046
138MP0005058_abnormal_lysosome_morphology0.63680980

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)8.68074422
2Joint hemorrhage (HP:0005261)5.93635359
3Prolonged partial thromboplastin time (HP:0003645)5.65549157
4Complement deficiency (HP:0004431)5.36395482
5Systemic lupus erythematosus (HP:0002725)4.63153768
6Abnormality of complement system (HP:0005339)4.52050676
7Hemorrhage of the eye (HP:0011885)4.38131532
8Hypobetalipoproteinemia (HP:0003563)4.28330279
9Abnormality of the common coagulation pathway (HP:0010990)4.23217576
10Elevated erythrocyte sedimentation rate (HP:0003565)4.15234586
11Xanthomatosis (HP:0000991)4.04440735
12IgM deficiency (HP:0002850)3.91347849
13Glomerulonephritis (HP:0000099)3.70309341
14T lymphocytopenia (HP:0005403)3.68514965
15Menorrhagia (HP:0000132)3.54165659
16Abnormality of T cells (HP:0002843)3.52283348
17Abnormality of monocarboxylic acid metabolism (HP:0010996)3.51660055
18Recurrent bronchitis (HP:0002837)3.45286148
19Abnormality of T cell number (HP:0011839)3.43622571
20Purpura (HP:0000979)3.43078686
21Hypercholesterolemia (HP:0003124)3.42465930
22Recurrent abscess formation (HP:0002722)3.32746213
23Abnormality of T cell physiology (HP:0011840)3.32293804
24Thrombocytosis (HP:0001894)3.31181008
25Recurrent fungal infections (HP:0002841)3.19844058
26Chronic otitis media (HP:0000389)3.15721432
27Abnormal delayed hypersensitivity skin test (HP:0002963)3.13354528
28Abnormality of the lumbar spine (HP:0100712)3.06711312
29Recurrent viral infections (HP:0004429)3.03128995
30Eczematoid dermatitis (HP:0000976)2.99975643
31Pustule (HP:0200039)2.98045727
32Combined immunodeficiency (HP:0005387)2.96893250
33Spontaneous abortion (HP:0005268)2.91659286
34Nasal polyposis (HP:0100582)2.89445599
35Petechiae (HP:0000967)2.85687333
36Thrombophlebitis (HP:0004418)2.79587777
37Agammaglobulinemia (HP:0004432)2.78185970
38Hypolipoproteinemia (HP:0010981)2.77864697
39Abnormality of cells of the erythroid lineage (HP:0012130)2.77148712
40Myositis (HP:0100614)2.74255313
41Chronic mucocutaneous candidiasis (HP:0002728)2.72497840
42Recurrent cutaneous fungal infections (HP:0011370)2.72497840
43Chronic diarrhea (HP:0002028)2.71981377
44Type I transferrin isoform profile (HP:0003642)2.71159047
45Recurrent bacterial skin infections (HP:0005406)2.69050662
46Abnormal number of erythroid precursors (HP:0012131)2.67332232
47Severe combined immunodeficiency (HP:0004430)2.66238216
48Poikiloderma (HP:0001029)2.62438078
49Panhypogammaglobulinemia (HP:0003139)2.61784728
50Myocardial infarction (HP:0001658)2.59724669
51Basal cell carcinoma (HP:0002671)2.57989089
52Hypoplasia of the thymus (HP:0000778)2.57750887
53Gastrointestinal inflammation (HP:0004386)2.49458712
54Abnormality of carpal bone ossification (HP:0006257)2.49258340
55Reduced antithrombin III activity (HP:0001976)2.48235288
56Hyperlipoproteinemia (HP:0010980)2.48006171
57Abnormality of the intrinsic pathway (HP:0010989)2.47607487
58Aplastic anemia (HP:0001915)2.47591168
59Meningitis (HP:0001287)2.47554223
60Abnormality of the nasal mucosa (HP:0000433)2.46724893
61Inflammation of the large intestine (HP:0002037)2.44166759
62Small epiphyses (HP:0010585)2.40095352
63Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.38793988
64Abnormal protein N-linked glycosylation (HP:0012347)2.38793988
65Abnormal protein glycosylation (HP:0012346)2.38793988
66Abnormal glycosylation (HP:0012345)2.38793988
67Abnormality of polysaccharide metabolism (HP:0011012)2.38737563
68Abnormality of glycosaminoglycan metabolism (HP:0004371)2.38737563
69Abnormality of mucopolysaccharide metabolism (HP:0011020)2.38737563
70Reticulocytopenia (HP:0001896)2.38328862
71Flat acetabular roof (HP:0003180)2.34334182
72Multiple enchondromatosis (HP:0005701)2.34104806
73Lymphoma (HP:0002665)2.32982239
74IgG deficiency (HP:0004315)2.32057826
75Conjugated hyperbilirubinemia (HP:0002908)2.27504741
76Recurrent skin infections (HP:0001581)2.27031760
77Cheilitis (HP:0100825)2.26877547
78Ependymoma (HP:0002888)2.26497368
79Increased serum ferritin (HP:0003281)2.26482412
80Stomatitis (HP:0010280)2.25837762
81Pulmonary embolism (HP:0002204)2.25442723
82Hypoalphalipoproteinemia (HP:0003233)2.24532327
83Lymphopenia (HP:0001888)2.22685337
84Thyroiditis (HP:0100646)2.21673101
85Epistaxis (HP:0000421)2.21601939
86Prolonged bleeding time (HP:0003010)2.19709038
87Abnormality of cells of the lymphoid lineage (HP:0012140)2.19523600
88Asymmetry of the thorax (HP:0001555)2.18200930
89Cellulitis (HP:0100658)2.17513621
90Nephritis (HP:0000123)2.17513137
91Abnormality of the Achilles tendon (HP:0005109)2.17188852
92Epiphyseal dysplasia (HP:0002656)2.14912469
93Agnosia (HP:0010524)2.14038916
94Hypochromic anemia (HP:0001931)2.13617803
95Hypertriglyceridemia (HP:0002155)2.13234122
96Abnormality of the thoracic spine (HP:0100711)2.12959097
97Acute lymphatic leukemia (HP:0006721)2.11985218
98Thoracic kyphosis (HP:0002942)2.11520354
9911 pairs of ribs (HP:0000878)2.11185456
100Abnormality of the peritoneum (HP:0002585)2.09494671
101Protrusio acetabuli (HP:0003179)2.09480552
102Recurrent sinusitis (HP:0011108)2.09005623
103Hypoglycemic coma (HP:0001325)2.07973465
104Vascular calcification (HP:0004934)2.07680551
105Impaired platelet aggregation (HP:0003540)2.07665445
106Abnormal platelet function (HP:0011869)2.07665445
107Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.06038922
108Amyloidosis (HP:0011034)2.05219145
109Bronchitis (HP:0012387)2.02872852
110Recurrent gram-negative bacterial infections (HP:0005420)2.02328675
111Leukocytosis (HP:0001974)2.01665647
112Mediastinal lymphadenopathy (HP:0100721)2.01485033
113Obstructive lung disease (HP:0006536)2.00741159
114Chronic obstructive pulmonary disease (HP:0006510)2.00741159
115Flared iliac wings (HP:0002869)1.97658868
116Abnormality of B cell number (HP:0010975)1.97444028
117B lymphocytopenia (HP:0010976)1.97444028
118Polygenic inheritance (HP:0010982)1.96556808
119Periodontitis (HP:0000704)1.95691883
120Gingival bleeding (HP:0000225)1.95684932
121Intestinal fistula (HP:0100819)1.94789330
122Mucopolysacchariduria (HP:0008155)1.94567319
123Urinary glycosaminoglycan excretion (HP:0003541)1.94567319
124Vacuolated lymphocytes (HP:0001922)1.93358356
125Hepatocellular carcinoma (HP:0001402)1.93248771
126Hyperinsulinemic hypoglycemia (HP:0000825)1.92755504
127Myelodysplasia (HP:0002863)1.92741404
128Amaurosis fugax (HP:0100576)1.92414272
129Abnormality of eosinophils (HP:0001879)1.91670456
130Abnormal ossification of hand bones (HP:0005921)1.91493628
131Autoimmune thrombocytopenia (HP:0001973)1.90679406
132Abnormality of the anterior horn cell (HP:0006802)1.90562116
133Degeneration of anterior horn cells (HP:0002398)1.90562116
134Colitis (HP:0002583)1.89296085
135Acanthocytosis (HP:0001927)1.86121570
136Abnormal tarsal ossification (HP:0008369)1.85830628
137Gingivitis (HP:0000230)1.85572875
138Abnormality of the pancreatic islet cells (HP:0006476)1.85537527
139Abnormality of endocrine pancreas physiology (HP:0012093)1.85537527
140Broad alveolar ridges (HP:0000187)1.85437112
141Abnormality of macrophages (HP:0004311)1.85001566
142Microcytic anemia (HP:0001935)1.83923365
143Orchitis (HP:0100796)1.83912439
144Cardiovascular calcification (HP:0011915)1.81457954
145Abnormality of the fingertips (HP:0001211)1.80982121
146Granulocytopenia (HP:0001913)1.80807395
147Abnormality of the prostate (HP:0008775)1.80724135
148Abnormality of iron homeostasis (HP:0011031)1.80539518
149Spontaneous hematomas (HP:0007420)1.80524787
150Progressive muscle weakness (HP:0003323)1.78278897
151Aplasia/Hypoplasia of the thymus (HP:0010515)1.78206768
152Abnormality of aromatic amino acid family metabolism (HP:0004338)1.77789555
153Hypergammaglobulinemia (HP:0010702)1.76705412
154Vasculitis (HP:0002633)1.76533892
155Pallor (HP:0000980)1.76144523
156Pancreatic islet-cell hyperplasia (HP:0004510)1.76060665
157Broad palm (HP:0001169)1.75754929
158Dysostosis multiplex (HP:0000943)1.75420368
159Vaginal fistula (HP:0004320)1.74410543
160Intrahepatic cholestasis (HP:0001406)1.74349421
161Gangrene (HP:0100758)1.73951897
162Seborrheic dermatitis (HP:0001051)1.72223531
163Biconcave vertebral bodies (HP:0004586)1.70650319
164J-shaped sella turcica (HP:0002680)1.70147182
165Abnormal enzyme/coenzyme activity (HP:0012379)1.69840392
166Abnormality of transition element cation homeostasis (HP:0011030)1.67225083
167Arterial thrombosis (HP:0004420)1.66858607
168Enlarged kidneys (HP:0000105)1.66834108
169Gastrointestinal infarctions (HP:0005244)1.66682055
170Abnormal hand bone ossification (HP:0010660)1.66383037
171Mitral stenosis (HP:0001718)1.66153045
172Vertebral compression fractures (HP:0002953)1.65850446
173Cholecystitis (HP:0001082)1.65635356
174Abnormal gallbladder physiology (HP:0012438)1.65635356
175Abnormality of the acetabulum (HP:0003170)1.62414631
176Abnormality of pyrimidine metabolism (HP:0004353)1.60318515
177Peritonitis (HP:0002586)1.58946913
178Abnormality of the pleura (HP:0002103)1.58831506

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.37030226
2FLT34.05803588
3ERN12.95860770
4TXK2.89541964
5TRIB32.78413113
6ICK2.63671820
7NME22.62890431
8KIT2.39176496
9ZAP702.26036878
10STK102.17472171
11SMG12.16738471
12TEC2.16216394
13PRPF4B2.03695848
14PASK2.00688129
15GRK61.95217009
16CDK121.94956253
17CSF1R1.91968117
18EEF2K1.86983825
19BTK1.79851740
20JAK31.79047137
21IRAK41.75002106
22EIF2AK31.70081212
23TYK21.69221622
24ITK1.53917598
25TAOK31.53268726
26MAP3K101.52196406
27RIPK41.49658626
28PKN21.49300219
29IKBKE1.48171098
30MAP2K31.47121013
31BLK1.44988450
32MAP3K131.44916601
33RPS6KB21.38761978
34PIM11.33735228
35CSK1.30524808
36KDR1.30461681
37SIK21.26277924
38SYK1.25816162
39PIM21.23664908
40PDGFRA1.22262990
41LCK1.21001547
42ACVR1B1.20863947
43BCKDK1.15319985
44NLK1.14303892
45CDK71.12328814
46CDC42BPA1.11904885
47MAP3K141.08199517
48CDK41.07304443
49DDR21.06196949
50TBK11.04366710
51WNK41.03037119
52IKBKB0.99854439
53FGFR40.98821630
54MAP3K70.98787072
55PDPK10.98734276
56MST40.94296708
57LYN0.91525684
58HIPK20.90704578
59IRAK30.89703482
60MAPKAPK30.88094319
61MAP3K10.86463316
62RIPK10.84675191
63TGFBR10.84287443
64HCK0.83959435
65LRRK20.83019466
66TGFBR20.82822451
67PDK10.82718855
68ATR0.82569784
69TESK20.82397025
70FGR0.81969756
71DYRK30.81643148
72SCYL20.79658324
73MAP3K110.78391138
74MAPK150.77935661
75MAPK110.76515775
76EIF2AK10.75744476
77NEK20.75042665
78CDC70.74920155
79RPS6KA40.74644798
80TYRO30.73576573
81TNK20.72311028
82MAP3K80.72288716
83MAP3K30.72156643
84MAP2K60.70142228
85MATK0.69905879
86MAP2K20.68733056
87EPHA20.67905141
88PRKD20.67071211
89JAK10.66100015
90MAP3K60.64925673
91PRKAA20.63937012
92MTOR0.63234435
93STK160.62284829
94CHUK0.60515304
95CDK60.60115361
96CLK10.59851823
97RET0.58883628
98WEE10.58312227
99FGFR30.55401767
100CDK90.54378103
101JAK20.53952954
102FGFR10.53873254
103BMX0.53721954
104ARAF0.53682072
105TAOK10.51359989
106VRK10.50460469
107PRKG20.49196766
108NEK90.49026396
109TAOK20.48662486
110DAPK10.48415014
111WNK10.46868368
112CDK80.46631499
113MARK30.46330251
114INSRR0.46142406
115VRK20.46002334
116RPS6KA60.45959121
117MARK20.45938354
118SIK10.45842609
119STK40.45167679
120PTK60.43833875
121RPS6KC10.42692015
122RPS6KL10.42692015
123ALK0.42627929
124MAPKAPK20.42372078
125ADRBK20.41892996
126FES0.40819988
127MAP3K50.40764670
128AURKB0.40638634
129MST1R0.39590167
130MAPK40.39346987
131PAK40.38905194
132MAPK120.38832152
133DYRK1B0.36466028
134MAPK30.36343273
135PLK10.35346937
136NUAK10.34802976
137PIK3CA0.32772203

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.59620202
2DNA replication_Homo sapiens_hsa030303.47094670
3Primary immunodeficiency_Homo sapiens_hsa053403.30311861
4Mismatch repair_Homo sapiens_hsa034303.24642647
5Ribosome_Homo sapiens_hsa030102.78649282
6Base excision repair_Homo sapiens_hsa034102.42403114
7One carbon pool by folate_Homo sapiens_hsa006702.17133438
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.06795818
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.96796317
10Homologous recombination_Homo sapiens_hsa034401.91692094
11Arginine biosynthesis_Homo sapiens_hsa002201.90248929
12Protein export_Homo sapiens_hsa030601.84193379
13Antigen processing and presentation_Homo sapiens_hsa046121.79656027
14Other glycan degradation_Homo sapiens_hsa005111.79407429
15Folate biosynthesis_Homo sapiens_hsa007901.76355787
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.75533204
17Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.72821025
18Nucleotide excision repair_Homo sapiens_hsa034201.70904036
19Phenylalanine metabolism_Homo sapiens_hsa003601.70282153
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.69794322
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.63697703
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.59561471
23Measles_Homo sapiens_hsa051621.59415797
24Vitamin digestion and absorption_Homo sapiens_hsa049771.55810766
25Spliceosome_Homo sapiens_hsa030401.51613086
26Fatty acid degradation_Homo sapiens_hsa000711.51155481
27Pyrimidine metabolism_Homo sapiens_hsa002401.50089454
28Leishmaniasis_Homo sapiens_hsa051401.49694159
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46998915
30Hematopoietic cell lineage_Homo sapiens_hsa046401.46217194
31Sulfur relay system_Homo sapiens_hsa041221.46000579
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.44893253
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.44862395
34Selenocompound metabolism_Homo sapiens_hsa004501.43236536
35Herpes simplex infection_Homo sapiens_hsa051681.41174719
36PPAR signaling pathway_Homo sapiens_hsa033201.40443901
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.36515953
38N-Glycan biosynthesis_Homo sapiens_hsa005101.36501387
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.34503746
40Starch and sucrose metabolism_Homo sapiens_hsa005001.30338958
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28914441
42Non-homologous end-joining_Homo sapiens_hsa034501.28432315
43RNA polymerase_Homo sapiens_hsa030201.24426078
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.22912546
45Pertussis_Homo sapiens_hsa051331.21899977
46RNA transport_Homo sapiens_hsa030131.21647356
47Tyrosine metabolism_Homo sapiens_hsa003501.21363531
48Asthma_Homo sapiens_hsa053101.20789854
49T cell receptor signaling pathway_Homo sapiens_hsa046601.20596546
50B cell receptor signaling pathway_Homo sapiens_hsa046621.18956745
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.16993008
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12456351
53Acute myeloid leukemia_Homo sapiens_hsa052211.11225603
54Legionellosis_Homo sapiens_hsa051341.10113626
55Fatty acid metabolism_Homo sapiens_hsa012121.09747935
56RNA degradation_Homo sapiens_hsa030181.04846290
57Glycosaminoglycan degradation_Homo sapiens_hsa005311.04265309
58Steroid hormone biosynthesis_Homo sapiens_hsa001401.02499439
59Histidine metabolism_Homo sapiens_hsa003401.01773547
60Drug metabolism - other enzymes_Homo sapiens_hsa009831.01453794
61Fanconi anemia pathway_Homo sapiens_hsa034601.01364485
62Renin-angiotensin system_Homo sapiens_hsa046141.01011121
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.00832898
64Galactose metabolism_Homo sapiens_hsa000520.98438925
65Fatty acid biosynthesis_Homo sapiens_hsa000610.98185196
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96579614
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95518345
68Prion diseases_Homo sapiens_hsa050200.94990693
69p53 signaling pathway_Homo sapiens_hsa041150.91588765
70Osteoclast differentiation_Homo sapiens_hsa043800.90468054
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.89819905
72Carbon metabolism_Homo sapiens_hsa012000.89750729
73Retinol metabolism_Homo sapiens_hsa008300.89068231
74Pentose phosphate pathway_Homo sapiens_hsa000300.87741712
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86095795
76Steroid biosynthesis_Homo sapiens_hsa001000.85980052
77Staphylococcus aureus infection_Homo sapiens_hsa051500.84938716
78Cell cycle_Homo sapiens_hsa041100.84659014
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84469811
80Fructose and mannose metabolism_Homo sapiens_hsa000510.82149457
81Chemical carcinogenesis_Homo sapiens_hsa052040.81828069
82Influenza A_Homo sapiens_hsa051640.81716244
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81129432
84Thyroid cancer_Homo sapiens_hsa052160.80949854
85Bile secretion_Homo sapiens_hsa049760.80809553
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79954878
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79717668
88Proteasome_Homo sapiens_hsa030500.79532231
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.79363614
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.78701699
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76572253
92Insulin resistance_Homo sapiens_hsa049310.75928892
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75674122
94Sulfur metabolism_Homo sapiens_hsa009200.73673058
95Autoimmune thyroid disease_Homo sapiens_hsa053200.73449566
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69674512
97Apoptosis_Homo sapiens_hsa042100.69549224
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67416368
99Graft-versus-host disease_Homo sapiens_hsa053320.66841644
100Non-small cell lung cancer_Homo sapiens_hsa052230.64300923
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63974975
102Allograft rejection_Homo sapiens_hsa053300.63122587
103Epstein-Barr virus infection_Homo sapiens_hsa051690.63052998
104Viral carcinogenesis_Homo sapiens_hsa052030.62196295
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.61974606
106Biosynthesis of amino acids_Homo sapiens_hsa012300.60530215
107Systemic lupus erythematosus_Homo sapiens_hsa053220.58189827
108Peroxisome_Homo sapiens_hsa041460.57967322
109Hepatitis B_Homo sapiens_hsa051610.56044220
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.55961630
111Chronic myeloid leukemia_Homo sapiens_hsa052200.55756836
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.55671850
113Fat digestion and absorption_Homo sapiens_hsa049750.55469738
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.55203902
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55111121
116Type I diabetes mellitus_Homo sapiens_hsa049400.51838401
117HTLV-I infection_Homo sapiens_hsa051660.51685340
118Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51400636
119ABC transporters_Homo sapiens_hsa020100.50825149
120Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50624242
121African trypanosomiasis_Homo sapiens_hsa051430.50032114
122Tuberculosis_Homo sapiens_hsa051520.49880565
123Glycerolipid metabolism_Homo sapiens_hsa005610.48685546
124Arginine and proline metabolism_Homo sapiens_hsa003300.48633701
125Purine metabolism_Homo sapiens_hsa002300.48316398
126Bladder cancer_Homo sapiens_hsa052190.46465948
127mRNA surveillance pathway_Homo sapiens_hsa030150.46218459
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45816820
129Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45450801
130Toxoplasmosis_Homo sapiens_hsa051450.45105559
131Shigellosis_Homo sapiens_hsa051310.44434461
132Pancreatic cancer_Homo sapiens_hsa052120.43957044
133Platelet activation_Homo sapiens_hsa046110.43216121
134Arachidonic acid metabolism_Homo sapiens_hsa005900.42221435
135Linoleic acid metabolism_Homo sapiens_hsa005910.41685317
136alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41466758
137Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40726698
138Basal transcription factors_Homo sapiens_hsa030220.40524768
139Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40246950
140Lysine degradation_Homo sapiens_hsa003100.37951979
141Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37341550
142Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36151803
143TNF signaling pathway_Homo sapiens_hsa046680.35985463
144Notch signaling pathway_Homo sapiens_hsa043300.35481743
145Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34903917
146Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34587728
147Complement and coagulation cascades_Homo sapiens_hsa046100.33710180
148Lysosome_Homo sapiens_hsa041420.33405546
149Hepatitis C_Homo sapiens_hsa051600.33009944

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