SLC18A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1catecholamine biosynthetic process (GO:0042423)9.06951951
2catechol-containing compound biosynthetic process (GO:0009713)9.06951951
3* catecholamine transport (GO:0051937)8.60760437
4response to insecticide (GO:0017085)7.64793395
5dopamine metabolic process (GO:0042417)7.42025484
6neurotransmitter biosynthetic process (GO:0042136)7.26354045
7regulation of dopamine metabolic process (GO:0042053)7.25024605
8regulation of catecholamine metabolic process (GO:0042069)7.25024605
9neurotransmitter catabolic process (GO:0042135)7.13450915
10serotonin metabolic process (GO:0042428)6.73761090
11* monoamine transport (GO:0015844)6.46616850
12phenol-containing compound biosynthetic process (GO:0046189)6.32955254
13primary amino compound metabolic process (GO:1901160)6.25920598
14behavioral response to nicotine (GO:0035095)5.95118793
15synaptic transmission, cholinergic (GO:0007271)5.85091640
16toxin metabolic process (GO:0009404)5.69222679
17mating behavior (GO:0007617)5.59844627
18neuron cell-cell adhesion (GO:0007158)5.59583914
19neurotransmitter metabolic process (GO:0042133)5.55010134
20catecholamine metabolic process (GO:0006584)5.40086842
21catechol-containing compound metabolic process (GO:0009712)5.40086842
22synaptic transmission, dopaminergic (GO:0001963)5.22499367
23prepulse inhibition (GO:0060134)4.99586676
24regulation of dopamine secretion (GO:0014059)4.97530601
25synaptic vesicle exocytosis (GO:0016079)4.87358185
26norepinephrine metabolic process (GO:0042415)4.53028621
27multicellular organismal aging (GO:0010259)4.46671157
28negative regulation of calcium ion-dependent exocytosis (GO:0045955)4.39839188
29glutamate secretion (GO:0014047)4.29157904
30glycoside metabolic process (GO:0016137)4.19135450
31cellular response to nicotine (GO:0071316)4.19090047
32behavioral response to ethanol (GO:0048149)4.04885986
33positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.03932250
34positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.97477700
35* regulation of neurotransmitter levels (GO:0001505)3.93918264
36establishment of synaptic vesicle localization (GO:0097480)3.91180067
37synaptic vesicle transport (GO:0048489)3.91180067
38negative regulation of microtubule polymerization (GO:0031115)3.88207116
39regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.88031722
40regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.88031722
41inositol phosphate catabolic process (GO:0071545)3.86870878
42* response to cocaine (GO:0042220)3.84633531
43neurotransmitter uptake (GO:0001504)3.83957360
44regulation of short-term neuronal synaptic plasticity (GO:0048172)3.77747112
45regulation of synaptic transmission, dopaminergic (GO:0032225)3.76950773
46behavioral response to cocaine (GO:0048148)3.76764613
47neuron maturation (GO:0042551)3.76255825
48* neurotransmitter transport (GO:0006836)3.68731466
49water-soluble vitamin biosynthetic process (GO:0042364)3.65591934
50inositol phosphate dephosphorylation (GO:0046855)3.64009569
51phosphorylated carbohydrate dephosphorylation (GO:0046838)3.64009569
52ubiquinone metabolic process (GO:0006743)3.60298710
53response to water (GO:0009415)3.56060437
54amine biosynthetic process (GO:0009309)3.55568960
55cellular biogenic amine biosynthetic process (GO:0042401)3.55568960
56regulation of vesicle fusion (GO:0031338)3.54510909
57response to nicotine (GO:0035094)3.51547452
58negative regulation of hormone biosynthetic process (GO:0032353)3.48612667
59positive regulation of glycolytic process (GO:0045821)3.46626276
60positive regulation of neurotransmitter transport (GO:0051590)3.46316474
61positive regulation of cell size (GO:0045793)3.44885365
62* insulin secretion (GO:0030073)3.40481348
63regulation of glucokinase activity (GO:0033131)3.38370692
64regulation of hexokinase activity (GO:1903299)3.38370692
65response to iron ion (GO:0010039)3.37817057
66vocalization behavior (GO:0071625)3.35655460
67proline transport (GO:0015824)3.34945073
68enteric nervous system development (GO:0048484)3.34754164
69neuromuscular synaptic transmission (GO:0007274)3.32296320
70oxygen transport (GO:0015671)3.29367990
71adaptation of signaling pathway (GO:0023058)3.28257009
72* response to amphetamine (GO:0001975)3.25081170
73* neurotransmitter secretion (GO:0007269)3.24008595
74positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.23619352
75regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.22254416
76thrombin receptor signaling pathway (GO:0070493)3.20813845
77phenol-containing compound metabolic process (GO:0018958)3.20737714
78neuromuscular process controlling posture (GO:0050884)3.20246449
79response to pain (GO:0048265)3.17302362
80erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.16719567
81L-phenylalanine catabolic process (GO:0006559)3.16719567
82glycerophospholipid catabolic process (GO:0046475)3.15372197
83positive regulation of glomerulus development (GO:0090193)3.11590883
84polyol catabolic process (GO:0046174)3.10899284
85opioid receptor signaling pathway (GO:0038003)3.09468076
86platelet dense granule organization (GO:0060155)3.09007953
87neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.07046522
88ubiquinone biosynthetic process (GO:0006744)3.06757988
89definitive hemopoiesis (GO:0060216)3.06368711
90synaptic vesicle maturation (GO:0016188)3.04953181
91detection of calcium ion (GO:0005513)3.00286383
92aromatic amino acid family metabolic process (GO:0009072)2.97784208
93nerve growth factor signaling pathway (GO:0038180)2.96821339
94sympathetic nervous system development (GO:0048485)2.96367559
95response to manganese ion (GO:0010042)2.95805207
96regulation of oxidative phosphorylation (GO:0002082)2.95535334
97indolalkylamine metabolic process (GO:0006586)2.94168150
98fucose catabolic process (GO:0019317)2.94133685
99L-fucose metabolic process (GO:0042354)2.94133685
100L-fucose catabolic process (GO:0042355)2.94133685
101regulation of calcium ion-dependent exocytosis (GO:0017158)2.93625622
102negative regulation of hormone metabolic process (GO:0032351)2.93501373
103regulation of respiratory gaseous exchange (GO:0043576)2.89827402
104positive regulation of vesicle fusion (GO:0031340)2.87937192
105protein neddylation (GO:0045116)2.86352502
106striatum development (GO:0021756)2.84807078
107type B pancreatic cell development (GO:0003323)2.83078149
108establishment of vesicle localization (GO:0051650)2.81674310
109neuron remodeling (GO:0016322)2.81174915
110tyrosine metabolic process (GO:0006570)2.80537972
111regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.78641710
112response to histamine (GO:0034776)2.78424927
113negative regulation of heart rate (GO:0010459)2.78349715
114aggressive behavior (GO:0002118)2.73888707
115inner mitochondrial membrane organization (GO:0007007)2.73397593
116dopaminergic neuron differentiation (GO:0071542)2.72363004
117neuronal action potential (GO:0019228)2.71898981
118regulation of synaptic vesicle exocytosis (GO:2000300)2.71278814
119sensory perception of smell (GO:0007608)2.70774398
120exploration behavior (GO:0035640)2.70214857
121regulation of synapse structural plasticity (GO:0051823)2.70200531
122social behavior (GO:0035176)2.68835979
123intraspecies interaction between organisms (GO:0051703)2.68835979
124regulation of catecholamine secretion (GO:0050433)2.68704007
125auditory behavior (GO:0031223)2.67806968
126positive regulation of synapse assembly (GO:0051965)2.67166434
127establishment of protein localization to mitochondrial membrane (GO:0090151)2.66242159
128daunorubicin metabolic process (GO:0044597)2.65068838
129polyketide metabolic process (GO:0030638)2.65068838
130doxorubicin metabolic process (GO:0044598)2.65068838
131synapse assembly (GO:0007416)2.65020910
132protein localization to cilium (GO:0061512)2.64435049
133nitric oxide mediated signal transduction (GO:0007263)2.62779618
134L-phenylalanine metabolic process (GO:0006558)2.61748045
135erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.61748045
136negative regulation of exocytosis (GO:0045920)2.61025627
137positive regulation of vasculogenesis (GO:2001214)2.59168824
138kidney morphogenesis (GO:0060993)2.57289116
139lactate metabolic process (GO:0006089)2.49771350
140estrogen biosynthetic process (GO:0006703)2.49438013
141quinone biosynthetic process (GO:1901663)2.48362799
142positive regulation of growth hormone secretion (GO:0060124)2.44440165
143regulation of clathrin-mediated endocytosis (GO:2000369)2.43913233
144signal peptide processing (GO:0006465)2.43084476
145retinal cone cell development (GO:0046549)2.42595087
146eye photoreceptor cell development (GO:0042462)2.41008185
147* negative regulation of neurotransmitter transport (GO:0051589)2.39702411
148eating behavior (GO:0042755)2.38197770
149regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.37299564
150negative regulation of norepinephrine secretion (GO:0010700)2.32692210
151photoreceptor cell development (GO:0042461)2.29971546
152regulation of long-term neuronal synaptic plasticity (GO:0048169)2.29866290
153negative regulation of cytosolic calcium ion concentration (GO:0051481)2.29066580
154inositol phosphate-mediated signaling (GO:0048016)2.27120895
155dopamine biosynthetic process (GO:0042416)13.1606728
156phenol-containing compound catabolic process (GO:0019336)11.5995287
157alkaloid metabolic process (GO:0009820)10.9265769
158* dopamine transport (GO:0015872)10.6094656

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.31241384
2TAF15_26573619_Chip-Seq_HEK293_Human4.83658081
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.70626969
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.10725114
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.89830527
6GBX2_23144817_ChIP-Seq_PC3_Human3.76862083
7IGF1R_20145208_ChIP-Seq_DFB_Human3.64309860
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.21907845
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.97393048
10* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.74557761
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.51716163
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.46915286
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.42771896
14* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.38821385
15IKZF1_21737484_ChIP-ChIP_HCT116_Human2.38322044
16NR3C1_23031785_ChIP-Seq_PC12_Mouse2.30166045
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.28255134
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.21708479
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.20352217
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.19955854
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.15474230
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12779159
23SMAD_19615063_ChIP-ChIP_OVARY_Human2.12327946
24ZNF274_21170338_ChIP-Seq_K562_Hela2.08931978
25P300_19829295_ChIP-Seq_ESCs_Human2.04072648
26BP1_19119308_ChIP-ChIP_Hs578T_Human2.02931035
27SALL1_21062744_ChIP-ChIP_HESCs_Human2.01211700
28REST_21632747_ChIP-Seq_MESCs_Mouse1.97288330
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.91163174
30MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85344930
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.85170271
32FUS_26573619_Chip-Seq_HEK293_Human1.84728508
33* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.84289212
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.83324952
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.83324952
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.81432859
37EWS_26573619_Chip-Seq_HEK293_Human1.79365461
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78016841
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.75342050
40SMAD4_21799915_ChIP-Seq_A2780_Human1.70900883
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.64327377
42BCAT_22108803_ChIP-Seq_LS180_Human1.63726600
43REST_18959480_ChIP-ChIP_MESCs_Mouse1.63697901
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.60920457
45FLI1_21867929_ChIP-Seq_TH2_Mouse1.57692745
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56849121
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.55299929
48CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51392764
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42388813
50RNF2_27304074_Chip-Seq_NSC_Mouse1.41461124
51P53_22387025_ChIP-Seq_ESCs_Mouse1.37450803
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.36378068
53CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.34175451
54TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.33497697
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33230182
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32566684
57CDX2_22108803_ChIP-Seq_LS180_Human1.32340707
58CRX_20693478_ChIP-Seq_RETINA_Mouse1.30945304
59EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30527892
60E2F1_18555785_Chip-Seq_ESCs_Mouse1.30354289
61DROSHA_22980978_ChIP-Seq_HELA_Human1.30056675
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29501777
63TCF4_22108803_ChIP-Seq_LS180_Human1.25252543
64JUN_21703547_ChIP-Seq_K562_Human1.24975184
65CMYC_18555785_Chip-Seq_ESCs_Mouse1.24492749
66AR_25329375_ChIP-Seq_VCAP_Human1.24206785
67EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.23959567
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.23338044
69TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23208914
70EED_16625203_ChIP-ChIP_MESCs_Mouse1.22953436
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.22770641
72TP53_22573176_ChIP-Seq_HFKS_Human1.22600843
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.21442954
74CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.20198211
75ERG_21242973_ChIP-ChIP_JURKAT_Human1.19464749
76PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19409428
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.18948892
78FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18241441
79FOXA1_25329375_ChIP-Seq_VCAP_Human1.18241441
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17813599
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17076310
82VDR_22108803_ChIP-Seq_LS180_Human1.16345614
83OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16217918
84SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15126767
85NANOG_19829295_ChIP-Seq_ESCs_Human1.14657150
86SOX2_19829295_ChIP-Seq_ESCs_Human1.14657150
87CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.14530590
88PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14488072
89RNF2_27304074_Chip-Seq_ESCs_Mouse1.14249915
90* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12726975
91TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12690510
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12293401
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12293401
94STAT3_18555785_Chip-Seq_ESCs_Mouse1.11541840
95ER_23166858_ChIP-Seq_MCF-7_Human1.11135948
96FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10774751
97EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10644561
98* PRDM14_20953172_ChIP-Seq_ESCs_Human1.10595010
99SOX2_18555785_Chip-Seq_ESCs_Mouse1.10408433
100ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09668760
101STAT3_23295773_ChIP-Seq_U87_Human1.09123977
102SOX2_21211035_ChIP-Seq_LN229_Gbm1.07923395
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.07788274
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07059206
105LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06691116
106SMAD4_21741376_ChIP-Seq_EPCs_Human1.06530679
107P300_18555785_Chip-Seq_ESCs_Mouse1.05972936
108SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05606860
109NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05470908
110NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05470908
111FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05063537
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04908151
113SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04765717
114RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04490480
115SCL_19346495_ChIP-Seq_HPC-7_Human1.04341729
116SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04115998
117HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02518114
118TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02036235
119* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01978624
120KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.01581536
121TBL1_22424771_ChIP-Seq_293T_Human1.01341044
122NMYC_18555785_Chip-Seq_ESCs_Mouse1.01118672
123RUNX2_22187159_ChIP-Seq_PCA_Human0.99957098
124NFYB_21822215_ChIP-Seq_K562_Human0.99745384
125MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99278045
126HTT_18923047_ChIP-ChIP_STHdh_Human0.99010633
127TP53_18474530_ChIP-ChIP_U2OS_Human0.98763909
128TP53_16413492_ChIP-PET_HCT116_Human0.98579686
129PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96835926
130TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96300737
131NOTCH1_21737748_ChIP-Seq_TLL_Human0.96034838
132CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95802404
133MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95408687
134* TCF4_23295773_ChIP-Seq_U87_Human0.93802770
135NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92643247
136ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89539237
137KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89194335
138KDM2B_26808549_Chip-Seq_REH_Human0.88600460
139PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.87833930
140IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86914462
141CBP_20019798_ChIP-Seq_JUKART_Human0.86914462
142TAL1_26923725_Chip-Seq_HPCs_Mouse0.86804961
143EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86766921
144CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86760622

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006276_abnormal_autonomic_nervous5.37862302
2* MP0001905_abnormal_dopamine_level5.20803060
3MP0002822_catalepsy5.01388338
4MP0001529_abnormal_vocalization4.82526509
5MP0003880_abnormal_central_pattern4.30180042
6MP0003122_maternal_imprinting3.46953037
7MP0001501_abnormal_sleep_pattern3.35776966
8MP0001188_hyperpigmentation3.13507220
9MP0002139_abnormal_hepatobiliary_system3.10386400
10MP0009046_muscle_twitch2.73898175
11MP0004924_abnormal_behavior2.69064803
12MP0005386_behavior/neurological_phenoty2.69064803
13MP0003195_calcinosis2.66896064
14MP0004859_abnormal_synaptic_plasticity2.58288481
15* MP0003635_abnormal_synaptic_transmissio2.54790629
16MP0008872_abnormal_physiological_respon2.52710471
17MP0005409_darkened_coat_color2.41905018
18* MP0009745_abnormal_behavioral_response2.34283767
19MP0002909_abnormal_adrenal_gland2.32165252
20MP0005646_abnormal_pituitary_gland2.29311901
21MP0002064_seizures2.27992727
22MP0002733_abnormal_thermal_nociception2.26623873
23* MP0002572_abnormal_emotion/affect_behav2.15338997
24MP0000013_abnormal_adipose_tissue2.08339270
25MP0002638_abnormal_pupillary_reflex2.06684099
26MP0000569_abnormal_digit_pigmentation2.05240690
27MP0005423_abnormal_somatic_nervous2.03430509
28MP0002693_abnormal_pancreas_physiology1.94253009
29MP0002272_abnormal_nervous_system1.94242685
30MP0002102_abnormal_ear_morphology1.78511122
31MP0008004_abnormal_stomach_pH1.76466547
32MP0000538_abnormal_urinary_bladder1.74735592
33MP0001440_abnormal_grooming_behavior1.72824656
34MP0001486_abnormal_startle_reflex1.70339071
35MP0003283_abnormal_digestive_organ1.68516011
36MP0002557_abnormal_social/conspecific_i1.68438077
37* MP0002063_abnormal_learning/memory/cond1.66838896
38MP0001664_abnormal_digestion1.66009731
39MP0001970_abnormal_pain_threshold1.65985562
40MP0002734_abnormal_mechanical_nocicepti1.60272890
41MP0001968_abnormal_touch/_nociception1.58848019
42MP0010386_abnormal_urinary_bladder1.57767549
43MP0004142_abnormal_muscle_tone1.55176509
44MP0000465_gastrointestinal_hemorrhage1.54374388
45MP0002067_abnormal_sensory_capabilities1.52568071
46MP0004270_analgesia1.51493964
47* MP0005535_abnormal_body_temperature1.49772234
48MP0006072_abnormal_retinal_apoptosis1.49388103
49MP0001944_abnormal_pancreas_morphology1.48275622
50MP0002751_abnormal_autonomic_nervous1.40879223
51MP0002184_abnormal_innervation1.37919210
52MP0003868_abnormal_feces_composition1.37695033
53MP0005075_abnormal_melanosome_morpholog1.34081918
54MP0005645_abnormal_hypothalamus_physiol1.33683132
55MP0003172_abnormal_lysosome_physiology1.33550149
56MP0005220_abnormal_exocrine_pancreas1.31159610
57MP0000015_abnormal_ear_pigmentation1.28800179
58MP0009379_abnormal_foot_pigmentation1.28343485
59MP0005084_abnormal_gallbladder_morpholo1.27797091
60MP0002160_abnormal_reproductive_system1.26415577
61MP0003787_abnormal_imprinting1.26227623
62MP0003866_abnormal_defecation1.22738108
63MP0002078_abnormal_glucose_homeostasis1.20132732
64MP0000639_abnormal_adrenal_gland1.17240966
65MP0002736_abnormal_nociception_after1.16807904
66MP0010329_abnormal_lipoprotein_level1.13647421
67MP0005253_abnormal_eye_physiology1.12763298
68MP0000631_abnormal_neuroendocrine_gland1.11297954
69MP0005551_abnormal_eye_electrophysiolog1.10171954
70MP0003121_genomic_imprinting1.06136345
71MP0004811_abnormal_neuron_physiology1.01825624
72* MP0002066_abnormal_motor_capabilities/c0.99898675
73MP0002332_abnormal_exercise_endurance0.97807219
74MP0005410_abnormal_fertilization0.97671895
75MP0002163_abnormal_gland_morphology0.97217246
76MP0008995_early_reproductive_senescence0.96867738
77MP0005389_reproductive_system_phenotype0.95822493
78MP0001502_abnormal_circadian_rhythm0.95239865
79MP0005332_abnormal_amino_acid0.93982937
80MP0003123_paternal_imprinting0.91374835
81MP0002735_abnormal_chemical_nociception0.91316922
82MP0003718_maternal_effect0.90137792
83MP0000955_abnormal_spinal_cord0.89596354
84MP0000427_abnormal_hair_cycle0.89196869
85MP0000383_abnormal_hair_follicle0.87141019
86MP0004215_abnormal_myocardial_fiber0.87125962
87MP0000747_muscle_weakness0.81925016
88MP0005187_abnormal_penis_morphology0.81862636
89MP0000778_abnormal_nervous_system0.81830539
90* MP0003953_abnormal_hormone_level0.81134876
91MP0004147_increased_porphyrin_level0.81128614
92MP0005379_endocrine/exocrine_gland_phen0.81089327
93MP0005167_abnormal_blood-brain_barrier0.79645076
94MP0008877_abnormal_DNA_methylation0.78936401
95MP0005248_abnormal_Harderian_gland0.77816671
96MP0001765_abnormal_ion_homeostasis0.77213125
97MP0008569_lethality_at_weaning0.76398642
98MP0009697_abnormal_copulation0.75518998
99MP0010678_abnormal_skin_adnexa0.74962343
100MP0006036_abnormal_mitochondrial_physio0.74556306
101MP0005636_abnormal_mineral_homeostasis0.74039989
102* MP0002882_abnormal_neuron_morphology0.73688653
103MP0000372_irregular_coat_pigmentation0.72953265
104MP0003724_increased_susceptibility_to0.72508485
105MP0004133_heterotaxia0.72202373
106MP0008057_abnormal_DNA_replication0.71469355
107MP0000003_abnormal_adipose_tissue0.71060723
108MP0003638_abnormal_response/metabolism_0.70894879
109MP0003786_premature_aging0.70871190
110MP0005171_absent_coat_pigmentation0.69025453
111MP0003890_abnormal_embryonic-extraembry0.68369501
112MP0001756_abnormal_urination0.66440089
113MP0005464_abnormal_platelet_physiology0.65014499
114MP0008775_abnormal_heart_ventricle0.64663695
115MP0000462_abnormal_digestive_system0.62908020
116MP0005174_abnormal_tail_pigmentation0.62838524
117MP0002138_abnormal_hepatobiliary_system0.62804405
118MP0005448_abnormal_energy_balance0.62332309
119MP0002090_abnormal_vision0.60880082
120* MP0003631_nervous_system_phenotype0.60783919
121MP0003942_abnormal_urinary_system0.60144965
122MP0003633_abnormal_nervous_system0.60085239
123MP0000681_abnormal_thyroid_gland0.60054775
124MP0001943_abnormal_respiration0.59545056
125* MP0008874_decreased_physiological_sensi0.59125201
126MP0001984_abnormal_olfaction0.58446167
127MP0001881_abnormal_mammary_gland0.58398530
128MP0004883_abnormal_blood_vessel0.58046466
129MP0002177_abnormal_outer_ear0.57024891
130MP0002152_abnormal_brain_morphology0.55917625
131MP0001986_abnormal_taste_sensitivity0.55489412
132MP0000751_myopathy0.54153181
133MP0004085_abnormal_heartbeat0.52597974
134MP0002837_dystrophic_cardiac_calcinosis0.51371551
135* MP0002069_abnormal_eating/drinking_beha0.50995796
136MP0000534_abnormal_ureter_morphology0.50446909
137MP0006035_abnormal_mitochondrial_morpho0.50010251
138MP0002876_abnormal_thyroid_physiology0.47318070
139MP0005499_abnormal_olfactory_system0.47296320
140MP0005394_taste/olfaction_phenotype0.47296320
141MP0004808_abnormal_hematopoietic_stem0.46722219
142MP0001340_abnormal_eyelid_morphology0.46233325
143MP0004742_abnormal_vestibular_system0.44443966
144MP0000230_abnormal_systemic_arterial0.44125726
145MP0005266_abnormal_metabolism0.44105469

Predicted human phenotypes

RankGene SetZ-score
1Parkinsonism with favorable response to dopaminergic medication (HP:0002548)5.74503469
2Abnormal pupillary function (HP:0007686)5.49471329
3Pheochromocytoma (HP:0002666)5.46447648
4Neuroendocrine neoplasm (HP:0100634)5.17540722
5Limb hypertonia (HP:0002509)4.94603556
6Visual hallucinations (HP:0002367)4.52232271
7Failure to thrive in infancy (HP:0001531)4.51219424
8Hypokinesia (HP:0002375)4.05116076
9Hypoventilation (HP:0002791)4.04408484
10Potter facies (HP:0002009)3.96151896
11Facial shape deformation (HP:0011334)3.96151896
12Petechiae (HP:0000967)3.86046002
13Increased mean platelet volume (HP:0011877)3.58049602
14Cerebral hemorrhage (HP:0001342)3.47258952
15Orthostatic hypotension (HP:0001278)3.45341760
16Myokymia (HP:0002411)3.34087937
17Delayed gross motor development (HP:0002194)3.31381974
18Progressive cerebellar ataxia (HP:0002073)3.29026224
19Abnormality of aromatic amino acid family metabolism (HP:0004338)3.25724362
20Abnormality of calcium-phosphate metabolism (HP:0100530)3.24622098
21Abnormal platelet volume (HP:0011876)3.24250265
22Dyskinesia (HP:0100660)3.20447262
23Muscular hypotonia of the trunk (HP:0008936)3.16377010
24Hypoglycemic seizures (HP:0002173)3.05894783
25Hyperinsulinemic hypoglycemia (HP:0000825)3.03189900
26Menorrhagia (HP:0000132)2.98920122
27Hypercortisolism (HP:0001578)2.98797286
28Abnormal hair whorl (HP:0010721)2.96294141
29Diminished movement (HP:0002374)2.95123401
30Focal motor seizures (HP:0011153)2.92996517
31Neoplasm of the peripheral nervous system (HP:0100007)2.90601508
32Mitochondrial inheritance (HP:0001427)2.90313146
33Focal seizures (HP:0007359)2.88373852
34Abnormality of endocrine pancreas physiology (HP:0012093)2.87589383
35Abnormality of the pancreatic islet cells (HP:0006476)2.87589383
36Purpura (HP:0000979)2.86169359
37Agitation (HP:0000713)2.83276104
38Poor suck (HP:0002033)2.79727803
39Hypoglycemic coma (HP:0001325)2.77452051
40Acute necrotizing encephalopathy (HP:0006965)2.73336836
41Rigidity (HP:0002063)2.69166134
42Metaphyseal dysplasia (HP:0100255)2.67804621
43Anxiety (HP:0000739)2.66975471
44Morphological abnormality of the pyramidal tract (HP:0002062)2.65329098
45Progressive inability to walk (HP:0002505)2.64725596
46Ketoacidosis (HP:0001993)2.64248733
47Hepatocellular necrosis (HP:0001404)2.64075020
48Emotional lability (HP:0000712)2.62461540
49Bradykinesia (HP:0002067)2.57010223
50Abnormality of the parathyroid morphology (HP:0011766)2.56544258
51Neoplasm of the adrenal cortex (HP:0100641)2.53331721
52Medial flaring of the eyebrow (HP:0010747)2.52572726
53Abnormal mitochondria in muscle tissue (HP:0008316)2.52182145
54Diastasis recti (HP:0001540)2.49969503
55Abnormal autonomic nervous system physiology (HP:0012332)2.48562372
56Thyroid carcinoma (HP:0002890)2.47460993
57Increased hepatocellular lipid droplets (HP:0006565)2.45653880
58Postural tremor (HP:0002174)2.44554289
59Increased CSF lactate (HP:0002490)2.44440690
60Gastroesophageal reflux (HP:0002020)2.43653227
61Hyperventilation (HP:0002883)2.41979220
62Epistaxis (HP:0000421)2.38301364
63Aplastic anemia (HP:0001915)2.36658442
64Progressive macrocephaly (HP:0004481)2.36471433
65Papilledema (HP:0001085)2.36059740
66Type II lissencephaly (HP:0007260)2.34004622
67Methylmalonic acidemia (HP:0002912)2.32317812
68Gaze-evoked nystagmus (HP:0000640)2.31943543
69Episodic fever (HP:0001954)2.28231259
70Hypotension (HP:0002615)2.27968957
71Pancreatic islet-cell hyperplasia (HP:0004510)2.27839478
72Neuroblastoma (HP:0003006)2.26903052
73Primitive neuroectodermal tumor (HP:0030065)2.26903052
74Neuroblastic tumors (HP:0004376)2.26903052
75Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.26903052
76Abnormality of vitamin B metabolism (HP:0004340)2.26342680
77EEG with generalized epileptiform discharges (HP:0011198)2.22526837
78Hyperglycemia (HP:0003074)2.18459309
79Generalized tonic-clonic seizures (HP:0002069)2.17824616
80Arthropathy (HP:0003040)2.16844894
81Pancreatic fibrosis (HP:0100732)2.16812095
82Hypomagnesemia (HP:0002917)2.15011818
83Epileptiform EEG discharges (HP:0011182)2.14110982
84Psychosis (HP:0000709)2.12984829
85Gait imbalance (HP:0002141)2.12148641
86Dialeptic seizures (HP:0011146)2.11564906
87Choreoathetosis (HP:0001266)2.10318843
88Myoclonus (HP:0001336)2.09145125
89Gingival bleeding (HP:0000225)2.08983740
90Ventricular fibrillation (HP:0001663)2.08822486
91Nephrogenic diabetes insipidus (HP:0009806)2.08214175
92Lipid accumulation in hepatocytes (HP:0006561)2.05919373
93Genital tract atresia (HP:0001827)2.05779334
94Polydipsia (HP:0001959)2.04726071
95Abnormal drinking behavior (HP:0030082)2.04726071
96Congenital primary aphakia (HP:0007707)2.03892985
97Hypsarrhythmia (HP:0002521)2.03841355
98Hyperthyroidism (HP:0000836)2.01424935
99Menstrual irregularities (HP:0000858)2.01339317
100Fetal akinesia sequence (HP:0001989)2.00114011
101Limb dystonia (HP:0002451)14.2548919
102Hypothermia (HP:0002045)10.7401053
103Hyperlipoproteinemia (HP:0010980)1.97935864
104Nephronophthisis (HP:0000090)1.97624718
105Abnormality of methionine metabolism (HP:0010901)1.97145372
106Mesangial abnormality (HP:0001966)1.96986039
107Acute encephalopathy (HP:0006846)1.96499850
108Metabolic alkalosis (HP:0200114)1.96150092
109Depression (HP:0000716)1.95820218
110Truncal ataxia (HP:0002078)1.93827277
111Insulin-resistant diabetes mellitus (HP:0000831)1.92867117
112Vaginal atresia (HP:0000148)1.91282803
113Stomatitis (HP:0010280)1.90319353
114Abnormal rod and cone electroretinograms (HP:0008323)1.89758299
115Neonatal hypoglycemia (HP:0001998)1.89340292
116Symptomatic seizures (HP:0011145)1.89143955
117Abnormal platelet function (HP:0011869)1.89075631
118Impaired platelet aggregation (HP:0003540)1.89075631
119Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.88101761
120Hyperparathyroidism (HP:0000843)1.87819815
121Exotropia (HP:0000577)1.87758967
122Retinal dysplasia (HP:0007973)1.87452728
123Delusions (HP:0000746)1.87366950
124Febrile seizures (HP:0002373)1.86958341
125Torticollis (HP:0000473)1.86689204
126Abnormality of renal resorption (HP:0011038)1.86577111
127Atonic seizures (HP:0010819)1.85582652
128Hepatic necrosis (HP:0002605)1.84676560
129Polyphagia (HP:0002591)1.82842431
130Ankle clonus (HP:0011448)1.81984950
131Abnormality of the renal cortex (HP:0011035)1.80379616
132Abolished electroretinogram (ERG) (HP:0000550)1.80228187
133Abnormality of the vitamin B12 metabolism (HP:0004341)1.79900006
134Craniofacial dystonia (HP:0012179)1.79561341
135Epileptic encephalopathy (HP:0200134)1.79460228
136Abnormality of midbrain morphology (HP:0002418)1.79390389
137Molar tooth sign on MRI (HP:0002419)1.79390389
138Prolonged bleeding time (HP:0003010)1.79147689
139Exertional dyspnea (HP:0002875)1.78228227
140Tubulointerstitial nephritis (HP:0001970)1.77981355
141Increased intramyocellular lipid droplets (HP:0012240)1.77010940
142Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.76563395
143Esotropia (HP:0000565)1.75350597
144Mask-like facies (HP:0000298)1.74569039
145Heterochromia iridis (HP:0001100)1.74356137
146Oligomenorrhea (HP:0000876)1.74328993
147Amblyopia (HP:0000646)1.71231893
148Decreased central vision (HP:0007663)1.71086372
149Renal Fanconi syndrome (HP:0001994)1.69722330
150Absence seizures (HP:0002121)1.68965879
151Optic disc pallor (HP:0000543)1.68858538
152Large for gestational age (HP:0001520)1.68473007
153Cerebral inclusion bodies (HP:0100314)1.67884186
154Abnormality of the renal medulla (HP:0100957)1.67686260
155Postural instability (HP:0002172)1.66585044
156Neoplasm of the adrenal gland (HP:0100631)1.64920580
157Renal dysplasia (HP:0000110)1.64412306
158Goiter (HP:0000853)1.64100442
159Focal dystonia (HP:0004373)1.62484183
160Akinesia (HP:0002304)1.62137555
161Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.61690314
162Lactic acidosis (HP:0003128)1.58043143
163Type 2 muscle fiber atrophy (HP:0003554)1.55539287
164Decreased activity of mitochondrial respiratory chain (HP:0008972)1.54747305

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK55.89352773
2MAP3K125.35481978
3FRK5.13892924
4GRK53.19170113
5PNCK2.84105576
6MAP2K72.73406318
7BUB12.49701762
8MAP3K92.46909816
9NTRK12.42948201
10ARAF2.38723638
11TAOK32.37329316
12MAP3K42.37223349
13NTRK32.33852237
14TSSK62.06717348
15MAP4K22.00969704
16MST41.99414331
17MKNK21.98401985
18PIK3CG1.97294210
19CASK1.91501156
20MUSK1.90788676
21MAP2K41.89776840
22BMPR1B1.88230052
23MAP3K131.83941577
24GRK71.81906128
25ADRBK21.80802277
26GRK61.78000346
27PHKG21.77526536
28PHKG11.77526536
29STK161.77487448
30PLK21.77288660
31MATK1.73788479
32CDK191.63607752
33MINK11.61763769
34NUAK11.61545068
35STK31.57337065
36ACVR1B1.56276014
37CAMK2A1.48376095
38RET1.44412356
39FGFR21.38882995
40MAPK131.36602674
41GRK11.33362254
42TIE11.26746948
43DAPK21.24955448
44TGFBR11.22642841
45UHMK11.21183613
46ADRBK11.18622473
47BRSK21.14912041
48MYLK1.13215232
49KSR11.07821266
50TRPM71.03939619
51PTK2B1.03447772
52NTRK21.02177084
53SYK0.98560472
54TRIM280.98505711
55CDK180.92509451
56MARK10.90142688
57CDK150.89073010
58CAMK2D0.88270479
59CAMK2B0.87944370
60BMX0.86415009
61ZAK0.85313327
62CDK140.85000495
63CDK11A0.84504036
64CDK80.84238060
65FGR0.82778644
66PAK30.80288861
67CDK50.79651425
68NME20.78484183
69KIT0.76669308
70TEC0.75607269
71WNK40.75490554
72FES0.74082782
73PRKG10.73488604
74STK390.73466299
75SIK30.69891999
76CAMK2G0.69186193
77BCKDK0.67816930
78MOS0.67663028
79CAMKK20.67210584
80PRKCQ0.66205698
81MAP3K20.66017317
82YES10.65392045
83LATS20.64610592
84RPS6KA50.64439116
85TNIK0.64363691
86KSR20.63108646
87TAOK10.62971546
88DAPK10.62694367
89FGFR30.61068151
90PRKCG0.60314594
91IRAK10.58985945
92PIK3CA0.56680916
93CDK30.51236017
94STK38L0.49972538
95NME10.48932906
96PLK30.48592819
97SGK10.46090754
98PRKACG0.45585924
99MAP2K10.45300323
100PRKAA10.45130950
101MAPKAPK30.44706989
102FLT30.44325607
103MAP3K60.44212269
104PRKG20.43981573
105RAF10.42176429
106TXK0.41864416
107ITK0.41066827
108DYRK1A0.40266300
109MAPK40.39971766
110WNK10.39955741
111PKN10.38690987
112PRKCE0.38333288
113PINK10.37902437
114OXSR10.37848718
115NLK0.37699555
116BMPR20.37542295
117PDK20.37417368
118MAP2K60.36856732
119SGK30.36819368
120AKT30.36559678
121TLK10.36402414
122ERBB40.36286503
123WNK30.36271064
124INSRR0.36032709
125MAP3K50.35852009
126EPHA30.35845248
127PRKACA0.35813063
128MKNK10.35370226
129CAMK10.35038260
130TNK20.34751562
131RPS6KA40.34455017
132RIPK40.32514397
133PTK20.32372270
134* PRKCA0.32142239
135SCYL20.31221370
136SGK20.30839873
137SGK4940.30723997
138SGK2230.30723997
139WEE10.30352892
140MAP3K10.29534922
141LYN0.29382635
142ERBB30.28406353
143IGF1R0.26373614
144STK110.25585051
145EIF2AK30.25583434
146RPS6KB10.24586878
147PRKACB0.23933934
148HIPK20.23837589
149* CSNK1G20.22364798

Predicted pathways (KEGG)

RankGene SetZ-score
1* Cocaine addiction_Homo sapiens_hsa050304.48094148
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.09334255
3Parkinsons disease_Homo sapiens_hsa050123.60086582
4* Synaptic vesicle cycle_Homo sapiens_hsa047213.56909680
5Tyrosine metabolism_Homo sapiens_hsa003503.38155847
6Phenylalanine metabolism_Homo sapiens_hsa003603.32553752
7* Amphetamine addiction_Homo sapiens_hsa050313.24089823
8Oxidative phosphorylation_Homo sapiens_hsa001903.18104485
9* Serotonergic synapse_Homo sapiens_hsa047263.07249026
10* Dopaminergic synapse_Homo sapiens_hsa047282.83356817
11Sulfur metabolism_Homo sapiens_hsa009202.69767303
12Nicotine addiction_Homo sapiens_hsa050332.67794597
13Collecting duct acid secretion_Homo sapiens_hsa049662.65493763
14Circadian rhythm_Homo sapiens_hsa047102.35567044
15Histidine metabolism_Homo sapiens_hsa003402.25770900
16Cholinergic synapse_Homo sapiens_hsa047252.25093613
17Nitrogen metabolism_Homo sapiens_hsa009102.21839226
18Alzheimers disease_Homo sapiens_hsa050102.04723530
19Vibrio cholerae infection_Homo sapiens_hsa051102.00743564
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.90119648
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.85006475
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.76360913
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.73973801
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.71265119
25Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.70906303
26Butanoate metabolism_Homo sapiens_hsa006501.68829978
27Circadian entrainment_Homo sapiens_hsa047131.66794814
28GABAergic synapse_Homo sapiens_hsa047271.65621450
29Huntingtons disease_Homo sapiens_hsa050161.57879582
30Regulation of autophagy_Homo sapiens_hsa041401.56240944
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.55401904
32Long-term depression_Homo sapiens_hsa047301.50888419
33Taste transduction_Homo sapiens_hsa047421.42363911
34* Alcoholism_Homo sapiens_hsa050341.41173640
35Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.37396561
36Morphine addiction_Homo sapiens_hsa050321.36261182
37Olfactory transduction_Homo sapiens_hsa047401.35299930
38Insulin secretion_Homo sapiens_hsa049111.30569608
39Tryptophan metabolism_Homo sapiens_hsa003801.28502048
40Glutamatergic synapse_Homo sapiens_hsa047241.27479096
41Salivary secretion_Homo sapiens_hsa049701.25263031
42Long-term potentiation_Homo sapiens_hsa047201.24160307
43Calcium signaling pathway_Homo sapiens_hsa040201.22700702
44Gap junction_Homo sapiens_hsa045401.22188530
45Selenocompound metabolism_Homo sapiens_hsa004501.20432572
46Renin secretion_Homo sapiens_hsa049241.20109049
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15230224
48Cardiac muscle contraction_Homo sapiens_hsa042601.11829432
49Aldosterone synthesis and secretion_Homo sapiens_hsa049251.06534899
50Ribosome_Homo sapiens_hsa030101.05580249
51African trypanosomiasis_Homo sapiens_hsa051431.04846106
52Rheumatoid arthritis_Homo sapiens_hsa053231.03481099
53Sphingolipid metabolism_Homo sapiens_hsa006001.02147042
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00788396
55Type II diabetes mellitus_Homo sapiens_hsa049300.95066513
56Proteasome_Homo sapiens_hsa030500.93484718
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93197054
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.90065791
59ABC transporters_Homo sapiens_hsa020100.89616161
60Gastric acid secretion_Homo sapiens_hsa049710.87104522
61Thyroid cancer_Homo sapiens_hsa052160.86353717
62GnRH signaling pathway_Homo sapiens_hsa049120.85879970
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82563218
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82078509
65Fatty acid elongation_Homo sapiens_hsa000620.74004390
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.73669934
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72502899
68Fatty acid biosynthesis_Homo sapiens_hsa000610.70666678
69Linoleic acid metabolism_Homo sapiens_hsa005910.69706233
70Asthma_Homo sapiens_hsa053100.69648772
71Arachidonic acid metabolism_Homo sapiens_hsa005900.67686556
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67673605
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66362850
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64282693
75Protein export_Homo sapiens_hsa030600.63398409
76Ovarian steroidogenesis_Homo sapiens_hsa049130.62210754
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62139981
78Thyroid hormone synthesis_Homo sapiens_hsa049180.61499041
79Estrogen signaling pathway_Homo sapiens_hsa049150.60864682
80Peroxisome_Homo sapiens_hsa041460.60329706
81Oxytocin signaling pathway_Homo sapiens_hsa049210.58472087
82Ether lipid metabolism_Homo sapiens_hsa005650.57773457
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.55341616
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.54680670
85Phagosome_Homo sapiens_hsa041450.54251624
86Glycerolipid metabolism_Homo sapiens_hsa005610.54186211
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52438562
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49932362
89Starch and sucrose metabolism_Homo sapiens_hsa005000.49667255
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48839631
91Platelet activation_Homo sapiens_hsa046110.48731536
92ECM-receptor interaction_Homo sapiens_hsa045120.48375522
93Pancreatic secretion_Homo sapiens_hsa049720.47023276
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46962869
95Inositol phosphate metabolism_Homo sapiens_hsa005620.46931316
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46499348
97Basal transcription factors_Homo sapiens_hsa030220.44596142
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42347660
99Oocyte meiosis_Homo sapiens_hsa041140.42019027
100Prolactin signaling pathway_Homo sapiens_hsa049170.41965910
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41738026
102mTOR signaling pathway_Homo sapiens_hsa041500.41151094
103Melanogenesis_Homo sapiens_hsa049160.40793333
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40184671
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39855354
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.36966175
107Pyruvate metabolism_Homo sapiens_hsa006200.36870818
108Dorso-ventral axis formation_Homo sapiens_hsa043200.36845772
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36664558
110Melanoma_Homo sapiens_hsa052180.36322538
111cAMP signaling pathway_Homo sapiens_hsa040240.36027461
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35106883
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34183575
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.30886635
115Glucagon signaling pathway_Homo sapiens_hsa049220.28925535
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.26944083
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26349633
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25127163
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.25059323
120Phototransduction_Homo sapiens_hsa047440.24414086
121Metabolic pathways_Homo sapiens_hsa011000.23084691
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.20770695
123Prion diseases_Homo sapiens_hsa050200.17908742
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.17606334
125Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.17031057
126Propanoate metabolism_Homo sapiens_hsa006400.15930519
127MAPK signaling pathway_Homo sapiens_hsa040100.15864421
128ErbB signaling pathway_Homo sapiens_hsa040120.15590850
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.15080990
130Type I diabetes mellitus_Homo sapiens_hsa049400.14571222
131Folate biosynthesis_Homo sapiens_hsa007900.14396703
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.11914428
133RNA degradation_Homo sapiens_hsa030180.10838084
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.10143645
135Renin-angiotensin system_Homo sapiens_hsa046140.10079501
136cGMP-PKG signaling pathway_Homo sapiens_hsa040220.09621831
137Purine metabolism_Homo sapiens_hsa002300.08001377

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