Rank | Gene Set | Z-score |
---|---|---|
1 | catechol-containing compound biosynthetic process (GO:0009713) | 9.06951951 |
2 | catecholamine biosynthetic process (GO:0042423) | 9.06951951 |
3 | * catecholamine transport (GO:0051937) | 8.60760437 |
4 | response to insecticide (GO:0017085) | 7.64793395 |
5 | dopamine metabolic process (GO:0042417) | 7.42025484 |
6 | neurotransmitter biosynthetic process (GO:0042136) | 7.26354045 |
7 | regulation of catecholamine metabolic process (GO:0042069) | 7.25024605 |
8 | regulation of dopamine metabolic process (GO:0042053) | 7.25024605 |
9 | neurotransmitter catabolic process (GO:0042135) | 7.13450915 |
10 | serotonin metabolic process (GO:0042428) | 6.73761090 |
11 | * monoamine transport (GO:0015844) | 6.46616850 |
12 | phenol-containing compound biosynthetic process (GO:0046189) | 6.32955254 |
13 | primary amino compound metabolic process (GO:1901160) | 6.25920598 |
14 | behavioral response to nicotine (GO:0035095) | 5.95118793 |
15 | synaptic transmission, cholinergic (GO:0007271) | 5.85091640 |
16 | toxin metabolic process (GO:0009404) | 5.69222679 |
17 | mating behavior (GO:0007617) | 5.59844627 |
18 | neuron cell-cell adhesion (GO:0007158) | 5.59583914 |
19 | neurotransmitter metabolic process (GO:0042133) | 5.55010134 |
20 | catechol-containing compound metabolic process (GO:0009712) | 5.40086842 |
21 | catecholamine metabolic process (GO:0006584) | 5.40086842 |
22 | synaptic transmission, dopaminergic (GO:0001963) | 5.22499367 |
23 | prepulse inhibition (GO:0060134) | 4.99586676 |
24 | regulation of dopamine secretion (GO:0014059) | 4.97530601 |
25 | synaptic vesicle exocytosis (GO:0016079) | 4.87358185 |
26 | norepinephrine metabolic process (GO:0042415) | 4.53028621 |
27 | multicellular organismal aging (GO:0010259) | 4.46671157 |
28 | negative regulation of calcium ion-dependent exocytosis (GO:0045955) | 4.39839188 |
29 | glutamate secretion (GO:0014047) | 4.29157904 |
30 | glycoside metabolic process (GO:0016137) | 4.19135450 |
31 | cellular response to nicotine (GO:0071316) | 4.19090047 |
32 | behavioral response to ethanol (GO:0048149) | 4.04885986 |
33 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 4.03932250 |
34 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 3.97477700 |
35 | * regulation of neurotransmitter levels (GO:0001505) | 3.93918264 |
36 | synaptic vesicle transport (GO:0048489) | 3.91180067 |
37 | establishment of synaptic vesicle localization (GO:0097480) | 3.91180067 |
38 | negative regulation of microtubule polymerization (GO:0031115) | 3.88207116 |
39 | regulation of dopamine uptake involved in synaptic transmission (GO:0051584) | 3.88031722 |
40 | regulation of catecholamine uptake involved in synaptic transmission (GO:0051940) | 3.88031722 |
41 | inositol phosphate catabolic process (GO:0071545) | 3.86870878 |
42 | * response to cocaine (GO:0042220) | 3.84633531 |
43 | neurotransmitter uptake (GO:0001504) | 3.83957360 |
44 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 3.77747112 |
45 | regulation of synaptic transmission, dopaminergic (GO:0032225) | 3.76950773 |
46 | behavioral response to cocaine (GO:0048148) | 3.76764613 |
47 | neuron maturation (GO:0042551) | 3.76255825 |
48 | * neurotransmitter transport (GO:0006836) | 3.68731466 |
49 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.65591934 |
50 | phosphorylated carbohydrate dephosphorylation (GO:0046838) | 3.64009569 |
51 | inositol phosphate dephosphorylation (GO:0046855) | 3.64009569 |
52 | ubiquinone metabolic process (GO:0006743) | 3.60298710 |
53 | response to water (GO:0009415) | 3.56060437 |
54 | cellular biogenic amine biosynthetic process (GO:0042401) | 3.55568960 |
55 | amine biosynthetic process (GO:0009309) | 3.55568960 |
56 | regulation of vesicle fusion (GO:0031338) | 3.54510909 |
57 | response to nicotine (GO:0035094) | 3.51547452 |
58 | negative regulation of hormone biosynthetic process (GO:0032353) | 3.48612667 |
59 | positive regulation of glycolytic process (GO:0045821) | 3.46626276 |
60 | positive regulation of neurotransmitter transport (GO:0051590) | 3.46316474 |
61 | positive regulation of cell size (GO:0045793) | 3.44885365 |
62 | * insulin secretion (GO:0030073) | 3.40481348 |
63 | regulation of hexokinase activity (GO:1903299) | 3.38370692 |
64 | regulation of glucokinase activity (GO:0033131) | 3.38370692 |
65 | response to iron ion (GO:0010039) | 3.37817057 |
66 | vocalization behavior (GO:0071625) | 3.35655460 |
67 | proline transport (GO:0015824) | 3.34945073 |
68 | enteric nervous system development (GO:0048484) | 3.34754164 |
69 | neuromuscular synaptic transmission (GO:0007274) | 3.32296320 |
70 | oxygen transport (GO:0015671) | 3.29367990 |
71 | adaptation of signaling pathway (GO:0023058) | 3.28257009 |
72 | * response to amphetamine (GO:0001975) | 3.25081170 |
73 | * neurotransmitter secretion (GO:0007269) | 3.24008595 |
74 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.23619352 |
75 | regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235 | 3.22254416 |
76 | thrombin receptor signaling pathway (GO:0070493) | 3.20813845 |
77 | phenol-containing compound metabolic process (GO:0018958) | 3.20737714 |
78 | neuromuscular process controlling posture (GO:0050884) | 3.20246449 |
79 | response to pain (GO:0048265) | 3.17302362 |
80 | L-phenylalanine catabolic process (GO:0006559) | 3.16719567 |
81 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 3.16719567 |
82 | glycerophospholipid catabolic process (GO:0046475) | 3.15372197 |
83 | positive regulation of glomerulus development (GO:0090193) | 3.11590883 |
84 | polyol catabolic process (GO:0046174) | 3.10899284 |
85 | opioid receptor signaling pathway (GO:0038003) | 3.09468076 |
86 | platelet dense granule organization (GO:0060155) | 3.09007953 |
87 | neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976) | 3.07046522 |
88 | ubiquinone biosynthetic process (GO:0006744) | 3.06757988 |
89 | definitive hemopoiesis (GO:0060216) | 3.06368711 |
90 | synaptic vesicle maturation (GO:0016188) | 3.04953181 |
91 | detection of calcium ion (GO:0005513) | 3.00286383 |
92 | aromatic amino acid family metabolic process (GO:0009072) | 2.97784208 |
93 | nerve growth factor signaling pathway (GO:0038180) | 2.96821339 |
94 | sympathetic nervous system development (GO:0048485) | 2.96367559 |
95 | response to manganese ion (GO:0010042) | 2.95805207 |
96 | regulation of oxidative phosphorylation (GO:0002082) | 2.95535334 |
97 | indolalkylamine metabolic process (GO:0006586) | 2.94168150 |
98 | L-fucose catabolic process (GO:0042355) | 2.94133685 |
99 | fucose catabolic process (GO:0019317) | 2.94133685 |
100 | L-fucose metabolic process (GO:0042354) | 2.94133685 |
101 | regulation of calcium ion-dependent exocytosis (GO:0017158) | 2.93625622 |
102 | negative regulation of hormone metabolic process (GO:0032351) | 2.93501373 |
103 | regulation of respiratory gaseous exchange (GO:0043576) | 2.89827402 |
104 | positive regulation of vesicle fusion (GO:0031340) | 2.87937192 |
105 | protein neddylation (GO:0045116) | 2.86352502 |
106 | striatum development (GO:0021756) | 2.84807078 |
107 | type B pancreatic cell development (GO:0003323) | 2.83078149 |
108 | establishment of vesicle localization (GO:0051650) | 2.81674310 |
109 | neuron remodeling (GO:0016322) | 2.81174915 |
110 | tyrosine metabolic process (GO:0006570) | 2.80537972 |
111 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 2.78641710 |
112 | response to histamine (GO:0034776) | 2.78424927 |
113 | negative regulation of heart rate (GO:0010459) | 2.78349715 |
114 | aggressive behavior (GO:0002118) | 2.73888707 |
115 | inner mitochondrial membrane organization (GO:0007007) | 2.73397593 |
116 | dopaminergic neuron differentiation (GO:0071542) | 2.72363004 |
117 | neuronal action potential (GO:0019228) | 2.71898981 |
118 | regulation of synaptic vesicle exocytosis (GO:2000300) | 2.71278814 |
119 | sensory perception of smell (GO:0007608) | 2.70774398 |
120 | exploration behavior (GO:0035640) | 2.70214857 |
121 | regulation of synapse structural plasticity (GO:0051823) | 2.70200531 |
122 | intraspecies interaction between organisms (GO:0051703) | 2.68835979 |
123 | social behavior (GO:0035176) | 2.68835979 |
124 | regulation of catecholamine secretion (GO:0050433) | 2.68704007 |
125 | auditory behavior (GO:0031223) | 2.67806968 |
126 | positive regulation of synapse assembly (GO:0051965) | 2.67166434 |
127 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 2.66242159 |
128 | doxorubicin metabolic process (GO:0044598) | 2.65068838 |
129 | daunorubicin metabolic process (GO:0044597) | 2.65068838 |
130 | polyketide metabolic process (GO:0030638) | 2.65068838 |
131 | synapse assembly (GO:0007416) | 2.65020910 |
132 | protein localization to cilium (GO:0061512) | 2.64435049 |
133 | nitric oxide mediated signal transduction (GO:0007263) | 2.62779618 |
134 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 2.61748045 |
135 | L-phenylalanine metabolic process (GO:0006558) | 2.61748045 |
136 | negative regulation of exocytosis (GO:0045920) | 2.61025627 |
137 | positive regulation of vasculogenesis (GO:2001214) | 2.59168824 |
138 | kidney morphogenesis (GO:0060993) | 2.57289116 |
139 | lactate metabolic process (GO:0006089) | 2.49771350 |
140 | estrogen biosynthetic process (GO:0006703) | 2.49438013 |
141 | quinone biosynthetic process (GO:1901663) | 2.48362799 |
142 | positive regulation of growth hormone secretion (GO:0060124) | 2.44440165 |
143 | regulation of clathrin-mediated endocytosis (GO:2000369) | 2.43913233 |
144 | signal peptide processing (GO:0006465) | 2.43084476 |
145 | retinal cone cell development (GO:0046549) | 2.42595087 |
146 | eye photoreceptor cell development (GO:0042462) | 2.41008185 |
147 | * negative regulation of neurotransmitter transport (GO:0051589) | 2.39702411 |
148 | eating behavior (GO:0042755) | 2.38197770 |
149 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 2.37299564 |
150 | negative regulation of norepinephrine secretion (GO:0010700) | 2.32692210 |
151 | photoreceptor cell development (GO:0042461) | 2.29971546 |
152 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 2.29866290 |
153 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 2.29066580 |
154 | inositol phosphate-mediated signaling (GO:0048016) | 2.27120895 |
155 | dopamine biosynthetic process (GO:0042416) | 13.1606728 |
156 | phenol-containing compound catabolic process (GO:0019336) | 11.5995287 |
157 | alkaloid metabolic process (GO:0009820) | 10.9265769 |
158 | * dopamine transport (GO:0015872) | 10.6094656 |
Rank | Gene Set | Z-score |
---|---|---|
1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.31241384 |
2 | TAF15_26573619_Chip-Seq_HEK293_Human | 4.83658081 |
3 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 4.70626969 |
4 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 4.10725114 |
5 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 3.89830527 |
6 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.76862083 |
7 | IGF1R_20145208_ChIP-Seq_DFB_Human | 3.64309860 |
8 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 3.21907845 |
9 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.97393048 |
10 | * SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.74557761 |
11 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 2.51716163 |
12 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.46915286 |
13 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.42771896 |
14 | * SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.38821385 |
15 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.38322044 |
16 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 2.30166045 |
17 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.28255134 |
18 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.21708479 |
19 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 2.20352217 |
20 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.19955854 |
21 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.15474230 |
22 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 2.12779159 |
23 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 2.12327946 |
24 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.08931978 |
25 | P300_19829295_ChIP-Seq_ESCs_Human | 2.04072648 |
26 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.02931035 |
27 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.01211700 |
28 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.97288330 |
29 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.91163174 |
30 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.85344930 |
31 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.85170271 |
32 | FUS_26573619_Chip-Seq_HEK293_Human | 1.84728508 |
33 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.84289212 |
34 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 1.83324952 |
35 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 1.83324952 |
36 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.81432859 |
37 | EWS_26573619_Chip-Seq_HEK293_Human | 1.79365461 |
38 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.78016841 |
39 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.75342050 |
40 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.70900883 |
41 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.64327377 |
42 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.63726600 |
43 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.63697901 |
44 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.60920457 |
45 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.57692745 |
46 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.56849121 |
47 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.55299929 |
48 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.51392764 |
49 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.42388813 |
50 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.41461124 |
51 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.37450803 |
52 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.36378068 |
53 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 1.34175451 |
54 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 1.33497697 |
55 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.33230182 |
56 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.32566684 |
57 | CDX2_22108803_ChIP-Seq_LS180_Human | 1.32340707 |
58 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.30945304 |
59 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.30527892 |
60 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.30354289 |
61 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.30056675 |
62 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.29501777 |
63 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.25252543 |
64 | JUN_21703547_ChIP-Seq_K562_Human | 1.24975184 |
65 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.24492749 |
66 | AR_25329375_ChIP-Seq_VCAP_Human | 1.24206785 |
67 | EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 1.23959567 |
68 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.23338044 |
69 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.23208914 |
70 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.22953436 |
71 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.22770641 |
72 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.22600843 |
73 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.21442954 |
74 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 1.20198211 |
75 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.19464749 |
76 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.19409428 |
77 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.18948892 |
78 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.18241441 |
79 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.18241441 |
80 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.17813599 |
81 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.17076310 |
82 | VDR_22108803_ChIP-Seq_LS180_Human | 1.16345614 |
83 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 1.16217918 |
84 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 1.15126767 |
85 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.14657150 |
86 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.14657150 |
87 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 1.14530590 |
88 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.14488072 |
89 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.14249915 |
90 | * OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.12726975 |
91 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.12690510 |
92 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.12293401 |
93 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.12293401 |
94 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 1.11541840 |
95 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.11135948 |
96 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 1.10774751 |
97 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.10644561 |
98 | * PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.10595010 |
99 | SOX2_18555785_Chip-Seq_ESCs_Mouse | 1.10408433 |
100 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.09668760 |
101 | STAT3_23295773_ChIP-Seq_U87_Human | 1.09123977 |
102 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.07923395 |
103 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.07788274 |
104 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.07059206 |
105 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.06691116 |
106 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 1.06530679 |
107 | P300_18555785_Chip-Seq_ESCs_Mouse | 1.05972936 |
108 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.05606860 |
109 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.05470908 |
110 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.05470908 |
111 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.05063537 |
112 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.04908151 |
113 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.04765717 |
114 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.04490480 |
115 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.04341729 |
116 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 1.04115998 |
117 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.02518114 |
118 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.02036235 |
119 | * LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.01978624 |
120 | KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse | 1.01581536 |
121 | TBL1_22424771_ChIP-Seq_293T_Human | 1.01341044 |
122 | NMYC_18555785_Chip-Seq_ESCs_Mouse | 1.01118672 |
123 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.99957098 |
124 | NFYB_21822215_ChIP-Seq_K562_Human | 0.99745384 |
125 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.99278045 |
126 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.99010633 |
127 | TP53_18474530_ChIP-ChIP_U2OS_Human | 0.98763909 |
128 | TP53_16413492_ChIP-PET_HCT116_Human | 0.98579686 |
129 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.96835926 |
130 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.96300737 |
131 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.96034838 |
132 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.95802404 |
133 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 0.95408687 |
134 | * TCF4_23295773_ChIP-Seq_U87_Human | 0.93802770 |
135 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.92643247 |
136 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.89539237 |
137 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.89194335 |
138 | KDM2B_26808549_Chip-Seq_REH_Human | 0.88600460 |
139 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.87833930 |
140 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.86914462 |
141 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.86914462 |
142 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 0.86804961 |
143 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.86766921 |
144 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.86760622 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0006276_abnormal_autonomic_nervous | 5.37862302 |
2 | * MP0001905_abnormal_dopamine_level | 5.20803060 |
3 | MP0002822_catalepsy | 5.01388338 |
4 | MP0001529_abnormal_vocalization | 4.82526509 |
5 | MP0003880_abnormal_central_pattern | 4.30180042 |
6 | MP0003122_maternal_imprinting | 3.46953037 |
7 | MP0001501_abnormal_sleep_pattern | 3.35776966 |
8 | MP0001188_hyperpigmentation | 3.13507220 |
9 | MP0002139_abnormal_hepatobiliary_system | 3.10386400 |
10 | MP0009046_muscle_twitch | 2.73898175 |
11 | MP0005386_behavior/neurological_phenoty | 2.69064803 |
12 | MP0004924_abnormal_behavior | 2.69064803 |
13 | MP0003195_calcinosis | 2.66896064 |
14 | MP0004859_abnormal_synaptic_plasticity | 2.58288481 |
15 | * MP0003635_abnormal_synaptic_transmissio | 2.54790629 |
16 | MP0008872_abnormal_physiological_respon | 2.52710471 |
17 | MP0005409_darkened_coat_color | 2.41905018 |
18 | * MP0009745_abnormal_behavioral_response | 2.34283767 |
19 | MP0002909_abnormal_adrenal_gland | 2.32165252 |
20 | MP0005646_abnormal_pituitary_gland | 2.29311901 |
21 | MP0002064_seizures | 2.27992727 |
22 | MP0002733_abnormal_thermal_nociception | 2.26623873 |
23 | * MP0002572_abnormal_emotion/affect_behav | 2.15338997 |
24 | MP0000013_abnormal_adipose_tissue | 2.08339270 |
25 | MP0002638_abnormal_pupillary_reflex | 2.06684099 |
26 | MP0000569_abnormal_digit_pigmentation | 2.05240690 |
27 | MP0005423_abnormal_somatic_nervous | 2.03430509 |
28 | MP0002693_abnormal_pancreas_physiology | 1.94253009 |
29 | MP0002272_abnormal_nervous_system | 1.94242685 |
30 | MP0002102_abnormal_ear_morphology | 1.78511122 |
31 | MP0008004_abnormal_stomach_pH | 1.76466547 |
32 | MP0000538_abnormal_urinary_bladder | 1.74735592 |
33 | MP0001440_abnormal_grooming_behavior | 1.72824656 |
34 | MP0001486_abnormal_startle_reflex | 1.70339071 |
35 | MP0003283_abnormal_digestive_organ | 1.68516011 |
36 | MP0002557_abnormal_social/conspecific_i | 1.68438077 |
37 | * MP0002063_abnormal_learning/memory/cond | 1.66838896 |
38 | MP0001664_abnormal_digestion | 1.66009731 |
39 | MP0001970_abnormal_pain_threshold | 1.65985562 |
40 | MP0002734_abnormal_mechanical_nocicepti | 1.60272890 |
41 | MP0001968_abnormal_touch/_nociception | 1.58848019 |
42 | MP0010386_abnormal_urinary_bladder | 1.57767549 |
43 | MP0004142_abnormal_muscle_tone | 1.55176509 |
44 | MP0000465_gastrointestinal_hemorrhage | 1.54374388 |
45 | MP0002067_abnormal_sensory_capabilities | 1.52568071 |
46 | MP0004270_analgesia | 1.51493964 |
47 | * MP0005535_abnormal_body_temperature | 1.49772234 |
48 | MP0006072_abnormal_retinal_apoptosis | 1.49388103 |
49 | MP0001944_abnormal_pancreas_morphology | 1.48275622 |
50 | MP0002751_abnormal_autonomic_nervous | 1.40879223 |
51 | MP0002184_abnormal_innervation | 1.37919210 |
52 | MP0003868_abnormal_feces_composition | 1.37695033 |
53 | MP0005075_abnormal_melanosome_morpholog | 1.34081918 |
54 | MP0005645_abnormal_hypothalamus_physiol | 1.33683132 |
55 | MP0003172_abnormal_lysosome_physiology | 1.33550149 |
56 | MP0005220_abnormal_exocrine_pancreas | 1.31159610 |
57 | MP0000015_abnormal_ear_pigmentation | 1.28800179 |
58 | MP0009379_abnormal_foot_pigmentation | 1.28343485 |
59 | MP0005084_abnormal_gallbladder_morpholo | 1.27797091 |
60 | MP0002160_abnormal_reproductive_system | 1.26415577 |
61 | MP0003787_abnormal_imprinting | 1.26227623 |
62 | MP0003866_abnormal_defecation | 1.22738108 |
63 | MP0002078_abnormal_glucose_homeostasis | 1.20132732 |
64 | MP0000639_abnormal_adrenal_gland | 1.17240966 |
65 | MP0002736_abnormal_nociception_after | 1.16807904 |
66 | MP0010329_abnormal_lipoprotein_level | 1.13647421 |
67 | MP0005253_abnormal_eye_physiology | 1.12763298 |
68 | MP0000631_abnormal_neuroendocrine_gland | 1.11297954 |
69 | MP0005551_abnormal_eye_electrophysiolog | 1.10171954 |
70 | MP0003121_genomic_imprinting | 1.06136345 |
71 | MP0004811_abnormal_neuron_physiology | 1.01825624 |
72 | * MP0002066_abnormal_motor_capabilities/c | 0.99898675 |
73 | MP0002332_abnormal_exercise_endurance | 0.97807219 |
74 | MP0005410_abnormal_fertilization | 0.97671895 |
75 | MP0002163_abnormal_gland_morphology | 0.97217246 |
76 | MP0008995_early_reproductive_senescence | 0.96867738 |
77 | MP0005389_reproductive_system_phenotype | 0.95822493 |
78 | MP0001502_abnormal_circadian_rhythm | 0.95239865 |
79 | MP0005332_abnormal_amino_acid | 0.93982937 |
80 | MP0003123_paternal_imprinting | 0.91374835 |
81 | MP0002735_abnormal_chemical_nociception | 0.91316922 |
82 | MP0003718_maternal_effect | 0.90137792 |
83 | MP0000955_abnormal_spinal_cord | 0.89596354 |
84 | MP0000427_abnormal_hair_cycle | 0.89196869 |
85 | MP0000383_abnormal_hair_follicle | 0.87141019 |
86 | MP0004215_abnormal_myocardial_fiber | 0.87125962 |
87 | MP0000747_muscle_weakness | 0.81925016 |
88 | MP0005187_abnormal_penis_morphology | 0.81862636 |
89 | MP0000778_abnormal_nervous_system | 0.81830539 |
90 | * MP0003953_abnormal_hormone_level | 0.81134876 |
91 | MP0004147_increased_porphyrin_level | 0.81128614 |
92 | MP0005379_endocrine/exocrine_gland_phen | 0.81089327 |
93 | MP0005167_abnormal_blood-brain_barrier | 0.79645076 |
94 | MP0008877_abnormal_DNA_methylation | 0.78936401 |
95 | MP0005248_abnormal_Harderian_gland | 0.77816671 |
96 | MP0001765_abnormal_ion_homeostasis | 0.77213125 |
97 | MP0008569_lethality_at_weaning | 0.76398642 |
98 | MP0009697_abnormal_copulation | 0.75518998 |
99 | MP0010678_abnormal_skin_adnexa | 0.74962343 |
100 | MP0006036_abnormal_mitochondrial_physio | 0.74556306 |
101 | MP0005636_abnormal_mineral_homeostasis | 0.74039989 |
102 | * MP0002882_abnormal_neuron_morphology | 0.73688653 |
103 | MP0000372_irregular_coat_pigmentation | 0.72953265 |
104 | MP0003724_increased_susceptibility_to | 0.72508485 |
105 | MP0004133_heterotaxia | 0.72202373 |
106 | MP0008057_abnormal_DNA_replication | 0.71469355 |
107 | MP0000003_abnormal_adipose_tissue | 0.71060723 |
108 | MP0003638_abnormal_response/metabolism_ | 0.70894879 |
109 | MP0003786_premature_aging | 0.70871190 |
110 | MP0005171_absent_coat_pigmentation | 0.69025453 |
111 | MP0003890_abnormal_embryonic-extraembry | 0.68369501 |
112 | MP0001756_abnormal_urination | 0.66440089 |
113 | MP0005464_abnormal_platelet_physiology | 0.65014499 |
114 | MP0008775_abnormal_heart_ventricle | 0.64663695 |
115 | MP0000462_abnormal_digestive_system | 0.62908020 |
116 | MP0005174_abnormal_tail_pigmentation | 0.62838524 |
117 | MP0002138_abnormal_hepatobiliary_system | 0.62804405 |
118 | MP0005448_abnormal_energy_balance | 0.62332309 |
119 | MP0002090_abnormal_vision | 0.60880082 |
120 | * MP0003631_nervous_system_phenotype | 0.60783919 |
121 | MP0003942_abnormal_urinary_system | 0.60144965 |
122 | MP0003633_abnormal_nervous_system | 0.60085239 |
123 | MP0000681_abnormal_thyroid_gland | 0.60054775 |
124 | MP0001943_abnormal_respiration | 0.59545056 |
125 | * MP0008874_decreased_physiological_sensi | 0.59125201 |
126 | MP0001984_abnormal_olfaction | 0.58446167 |
127 | MP0001881_abnormal_mammary_gland | 0.58398530 |
128 | MP0004883_abnormal_blood_vessel | 0.58046466 |
129 | MP0002177_abnormal_outer_ear | 0.57024891 |
130 | MP0002152_abnormal_brain_morphology | 0.55917625 |
131 | MP0001986_abnormal_taste_sensitivity | 0.55489412 |
132 | MP0000751_myopathy | 0.54153181 |
133 | MP0004085_abnormal_heartbeat | 0.52597974 |
134 | MP0002837_dystrophic_cardiac_calcinosis | 0.51371551 |
135 | * MP0002069_abnormal_eating/drinking_beha | 0.50995796 |
136 | MP0000534_abnormal_ureter_morphology | 0.50446909 |
137 | MP0006035_abnormal_mitochondrial_morpho | 0.50010251 |
138 | MP0002876_abnormal_thyroid_physiology | 0.47318070 |
139 | MP0005499_abnormal_olfactory_system | 0.47296320 |
140 | MP0005394_taste/olfaction_phenotype | 0.47296320 |
141 | MP0004808_abnormal_hematopoietic_stem | 0.46722219 |
142 | MP0001340_abnormal_eyelid_morphology | 0.46233325 |
143 | MP0004742_abnormal_vestibular_system | 0.44443966 |
144 | MP0000230_abnormal_systemic_arterial | 0.44125726 |
145 | MP0005266_abnormal_metabolism | 0.44105469 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 5.74503469 |
2 | Abnormal pupillary function (HP:0007686) | 5.49471329 |
3 | Pheochromocytoma (HP:0002666) | 5.46447648 |
4 | Neuroendocrine neoplasm (HP:0100634) | 5.17540722 |
5 | Limb hypertonia (HP:0002509) | 4.94603556 |
6 | Visual hallucinations (HP:0002367) | 4.52232271 |
7 | Failure to thrive in infancy (HP:0001531) | 4.51219424 |
8 | Hypokinesia (HP:0002375) | 4.05116076 |
9 | Hypoventilation (HP:0002791) | 4.04408484 |
10 | Potter facies (HP:0002009) | 3.96151896 |
11 | Facial shape deformation (HP:0011334) | 3.96151896 |
12 | Petechiae (HP:0000967) | 3.86046002 |
13 | Increased mean platelet volume (HP:0011877) | 3.58049602 |
14 | Cerebral hemorrhage (HP:0001342) | 3.47258952 |
15 | Orthostatic hypotension (HP:0001278) | 3.45341760 |
16 | Myokymia (HP:0002411) | 3.34087937 |
17 | Delayed gross motor development (HP:0002194) | 3.31381974 |
18 | Progressive cerebellar ataxia (HP:0002073) | 3.29026224 |
19 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 3.25724362 |
20 | Abnormality of calcium-phosphate metabolism (HP:0100530) | 3.24622098 |
21 | Abnormal platelet volume (HP:0011876) | 3.24250265 |
22 | Dyskinesia (HP:0100660) | 3.20447262 |
23 | Muscular hypotonia of the trunk (HP:0008936) | 3.16377010 |
24 | Hypoglycemic seizures (HP:0002173) | 3.05894783 |
25 | Hyperinsulinemic hypoglycemia (HP:0000825) | 3.03189900 |
26 | Menorrhagia (HP:0000132) | 2.98920122 |
27 | Hypercortisolism (HP:0001578) | 2.98797286 |
28 | Abnormal hair whorl (HP:0010721) | 2.96294141 |
29 | Diminished movement (HP:0002374) | 2.95123401 |
30 | Focal motor seizures (HP:0011153) | 2.92996517 |
31 | Neoplasm of the peripheral nervous system (HP:0100007) | 2.90601508 |
32 | Mitochondrial inheritance (HP:0001427) | 2.90313146 |
33 | Focal seizures (HP:0007359) | 2.88373852 |
34 | Abnormality of endocrine pancreas physiology (HP:0012093) | 2.87589383 |
35 | Abnormality of the pancreatic islet cells (HP:0006476) | 2.87589383 |
36 | Purpura (HP:0000979) | 2.86169359 |
37 | Agitation (HP:0000713) | 2.83276104 |
38 | Poor suck (HP:0002033) | 2.79727803 |
39 | Hypoglycemic coma (HP:0001325) | 2.77452051 |
40 | Acute necrotizing encephalopathy (HP:0006965) | 2.73336836 |
41 | Rigidity (HP:0002063) | 2.69166134 |
42 | Metaphyseal dysplasia (HP:0100255) | 2.67804621 |
43 | Anxiety (HP:0000739) | 2.66975471 |
44 | Morphological abnormality of the pyramidal tract (HP:0002062) | 2.65329098 |
45 | Progressive inability to walk (HP:0002505) | 2.64725596 |
46 | Ketoacidosis (HP:0001993) | 2.64248733 |
47 | Hepatocellular necrosis (HP:0001404) | 2.64075020 |
48 | Emotional lability (HP:0000712) | 2.62461540 |
49 | Bradykinesia (HP:0002067) | 2.57010223 |
50 | Abnormality of the parathyroid morphology (HP:0011766) | 2.56544258 |
51 | Neoplasm of the adrenal cortex (HP:0100641) | 2.53331721 |
52 | Medial flaring of the eyebrow (HP:0010747) | 2.52572726 |
53 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.52182145 |
54 | Diastasis recti (HP:0001540) | 2.49969503 |
55 | Abnormal autonomic nervous system physiology (HP:0012332) | 2.48562372 |
56 | Thyroid carcinoma (HP:0002890) | 2.47460993 |
57 | Increased hepatocellular lipid droplets (HP:0006565) | 2.45653880 |
58 | Postural tremor (HP:0002174) | 2.44554289 |
59 | Increased CSF lactate (HP:0002490) | 2.44440690 |
60 | Gastroesophageal reflux (HP:0002020) | 2.43653227 |
61 | Hyperventilation (HP:0002883) | 2.41979220 |
62 | Epistaxis (HP:0000421) | 2.38301364 |
63 | Aplastic anemia (HP:0001915) | 2.36658442 |
64 | Progressive macrocephaly (HP:0004481) | 2.36471433 |
65 | Papilledema (HP:0001085) | 2.36059740 |
66 | Type II lissencephaly (HP:0007260) | 2.34004622 |
67 | Methylmalonic acidemia (HP:0002912) | 2.32317812 |
68 | Gaze-evoked nystagmus (HP:0000640) | 2.31943543 |
69 | Episodic fever (HP:0001954) | 2.28231259 |
70 | Hypotension (HP:0002615) | 2.27968957 |
71 | Pancreatic islet-cell hyperplasia (HP:0004510) | 2.27839478 |
72 | Neuroblastoma (HP:0003006) | 2.26903052 |
73 | Primitive neuroectodermal tumor (HP:0030065) | 2.26903052 |
74 | Neuroblastic tumors (HP:0004376) | 2.26903052 |
75 | Peripheral primitive neuroectodermal neoplasm (HP:0030067) | 2.26903052 |
76 | Abnormality of vitamin B metabolism (HP:0004340) | 2.26342680 |
77 | EEG with generalized epileptiform discharges (HP:0011198) | 2.22526837 |
78 | Hyperglycemia (HP:0003074) | 2.18459309 |
79 | Generalized tonic-clonic seizures (HP:0002069) | 2.17824616 |
80 | Arthropathy (HP:0003040) | 2.16844894 |
81 | Pancreatic fibrosis (HP:0100732) | 2.16812095 |
82 | Hypomagnesemia (HP:0002917) | 2.15011818 |
83 | Epileptiform EEG discharges (HP:0011182) | 2.14110982 |
84 | Psychosis (HP:0000709) | 2.12984829 |
85 | Gait imbalance (HP:0002141) | 2.12148641 |
86 | Dialeptic seizures (HP:0011146) | 2.11564906 |
87 | Choreoathetosis (HP:0001266) | 2.10318843 |
88 | Myoclonus (HP:0001336) | 2.09145125 |
89 | Gingival bleeding (HP:0000225) | 2.08983740 |
90 | Ventricular fibrillation (HP:0001663) | 2.08822486 |
91 | Nephrogenic diabetes insipidus (HP:0009806) | 2.08214175 |
92 | Lipid accumulation in hepatocytes (HP:0006561) | 2.05919373 |
93 | Genital tract atresia (HP:0001827) | 2.05779334 |
94 | Polydipsia (HP:0001959) | 2.04726071 |
95 | Abnormal drinking behavior (HP:0030082) | 2.04726071 |
96 | Congenital primary aphakia (HP:0007707) | 2.03892985 |
97 | Hypsarrhythmia (HP:0002521) | 2.03841355 |
98 | Hyperthyroidism (HP:0000836) | 2.01424935 |
99 | Menstrual irregularities (HP:0000858) | 2.01339317 |
100 | Fetal akinesia sequence (HP:0001989) | 2.00114011 |
101 | Limb dystonia (HP:0002451) | 14.2548919 |
102 | Hypothermia (HP:0002045) | 10.7401053 |
103 | Hyperlipoproteinemia (HP:0010980) | 1.97935864 |
104 | Nephronophthisis (HP:0000090) | 1.97624718 |
105 | Abnormality of methionine metabolism (HP:0010901) | 1.97145372 |
106 | Mesangial abnormality (HP:0001966) | 1.96986039 |
107 | Acute encephalopathy (HP:0006846) | 1.96499850 |
108 | Metabolic alkalosis (HP:0200114) | 1.96150092 |
109 | Depression (HP:0000716) | 1.95820218 |
110 | Truncal ataxia (HP:0002078) | 1.93827277 |
111 | Insulin-resistant diabetes mellitus (HP:0000831) | 1.92867117 |
112 | Vaginal atresia (HP:0000148) | 1.91282803 |
113 | Stomatitis (HP:0010280) | 1.90319353 |
114 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.89758299 |
115 | Neonatal hypoglycemia (HP:0001998) | 1.89340292 |
116 | Symptomatic seizures (HP:0011145) | 1.89143955 |
117 | Abnormal platelet function (HP:0011869) | 1.89075631 |
118 | Impaired platelet aggregation (HP:0003540) | 1.89075631 |
119 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.88101761 |
120 | Hyperparathyroidism (HP:0000843) | 1.87819815 |
121 | Exotropia (HP:0000577) | 1.87758967 |
122 | Retinal dysplasia (HP:0007973) | 1.87452728 |
123 | Delusions (HP:0000746) | 1.87366950 |
124 | Febrile seizures (HP:0002373) | 1.86958341 |
125 | Torticollis (HP:0000473) | 1.86689204 |
126 | Abnormality of renal resorption (HP:0011038) | 1.86577111 |
127 | Atonic seizures (HP:0010819) | 1.85582652 |
128 | Hepatic necrosis (HP:0002605) | 1.84676560 |
129 | Polyphagia (HP:0002591) | 1.82842431 |
130 | Ankle clonus (HP:0011448) | 1.81984950 |
131 | Abnormality of the renal cortex (HP:0011035) | 1.80379616 |
132 | Abolished electroretinogram (ERG) (HP:0000550) | 1.80228187 |
133 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 1.79900006 |
134 | Craniofacial dystonia (HP:0012179) | 1.79561341 |
135 | Epileptic encephalopathy (HP:0200134) | 1.79460228 |
136 | Abnormality of midbrain morphology (HP:0002418) | 1.79390389 |
137 | Molar tooth sign on MRI (HP:0002419) | 1.79390389 |
138 | Prolonged bleeding time (HP:0003010) | 1.79147689 |
139 | Exertional dyspnea (HP:0002875) | 1.78228227 |
140 | Tubulointerstitial nephritis (HP:0001970) | 1.77981355 |
141 | Increased intramyocellular lipid droplets (HP:0012240) | 1.77010940 |
142 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 1.76563395 |
143 | Esotropia (HP:0000565) | 1.75350597 |
144 | Mask-like facies (HP:0000298) | 1.74569039 |
145 | Heterochromia iridis (HP:0001100) | 1.74356137 |
146 | Oligomenorrhea (HP:0000876) | 1.74328993 |
147 | Amblyopia (HP:0000646) | 1.71231893 |
148 | Decreased central vision (HP:0007663) | 1.71086372 |
149 | Renal Fanconi syndrome (HP:0001994) | 1.69722330 |
150 | Absence seizures (HP:0002121) | 1.68965879 |
151 | Optic disc pallor (HP:0000543) | 1.68858538 |
152 | Large for gestational age (HP:0001520) | 1.68473007 |
153 | Cerebral inclusion bodies (HP:0100314) | 1.67884186 |
154 | Abnormality of the renal medulla (HP:0100957) | 1.67686260 |
155 | Postural instability (HP:0002172) | 1.66585044 |
156 | Neoplasm of the adrenal gland (HP:0100631) | 1.64920580 |
157 | Renal dysplasia (HP:0000110) | 1.64412306 |
158 | Goiter (HP:0000853) | 1.64100442 |
159 | Focal dystonia (HP:0004373) | 1.62484183 |
160 | Akinesia (HP:0002304) | 1.62137555 |
161 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.61690314 |
162 | Lactic acidosis (HP:0003128) | 1.58043143 |
163 | Type 2 muscle fiber atrophy (HP:0003554) | 1.55539287 |
164 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.54747305 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MAPKAPK5 | 5.89352773 |
2 | MAP3K12 | 5.35481978 |
3 | FRK | 5.13892924 |
4 | GRK5 | 3.19170113 |
5 | PNCK | 2.84105576 |
6 | MAP2K7 | 2.73406318 |
7 | BUB1 | 2.49701762 |
8 | MAP3K9 | 2.46909816 |
9 | NTRK1 | 2.42948201 |
10 | ARAF | 2.38723638 |
11 | TAOK3 | 2.37329316 |
12 | MAP3K4 | 2.37223349 |
13 | NTRK3 | 2.33852237 |
14 | TSSK6 | 2.06717348 |
15 | MAP4K2 | 2.00969704 |
16 | MST4 | 1.99414331 |
17 | MKNK2 | 1.98401985 |
18 | PIK3CG | 1.97294210 |
19 | CASK | 1.91501156 |
20 | MUSK | 1.90788676 |
21 | MAP2K4 | 1.89776840 |
22 | BMPR1B | 1.88230052 |
23 | MAP3K13 | 1.83941577 |
24 | GRK7 | 1.81906128 |
25 | ADRBK2 | 1.80802277 |
26 | GRK6 | 1.78000346 |
27 | PHKG2 | 1.77526536 |
28 | PHKG1 | 1.77526536 |
29 | STK16 | 1.77487448 |
30 | PLK2 | 1.77288660 |
31 | MATK | 1.73788479 |
32 | CDK19 | 1.63607752 |
33 | MINK1 | 1.61763769 |
34 | NUAK1 | 1.61545068 |
35 | STK3 | 1.57337065 |
36 | ACVR1B | 1.56276014 |
37 | CAMK2A | 1.48376095 |
38 | RET | 1.44412356 |
39 | FGFR2 | 1.38882995 |
40 | MAPK13 | 1.36602674 |
41 | GRK1 | 1.33362254 |
42 | TIE1 | 1.26746948 |
43 | DAPK2 | 1.24955448 |
44 | TGFBR1 | 1.22642841 |
45 | UHMK1 | 1.21183613 |
46 | ADRBK1 | 1.18622473 |
47 | BRSK2 | 1.14912041 |
48 | MYLK | 1.13215232 |
49 | KSR1 | 1.07821266 |
50 | TRPM7 | 1.03939619 |
51 | PTK2B | 1.03447772 |
52 | NTRK2 | 1.02177084 |
53 | SYK | 0.98560472 |
54 | TRIM28 | 0.98505711 |
55 | CDK18 | 0.92509451 |
56 | MARK1 | 0.90142688 |
57 | CDK15 | 0.89073010 |
58 | CAMK2D | 0.88270479 |
59 | CAMK2B | 0.87944370 |
60 | BMX | 0.86415009 |
61 | ZAK | 0.85313327 |
62 | CDK14 | 0.85000495 |
63 | CDK11A | 0.84504036 |
64 | CDK8 | 0.84238060 |
65 | FGR | 0.82778644 |
66 | PAK3 | 0.80288861 |
67 | CDK5 | 0.79651425 |
68 | NME2 | 0.78484183 |
69 | KIT | 0.76669308 |
70 | TEC | 0.75607269 |
71 | WNK4 | 0.75490554 |
72 | FES | 0.74082782 |
73 | PRKG1 | 0.73488604 |
74 | STK39 | 0.73466299 |
75 | SIK3 | 0.69891999 |
76 | CAMK2G | 0.69186193 |
77 | BCKDK | 0.67816930 |
78 | MOS | 0.67663028 |
79 | CAMKK2 | 0.67210584 |
80 | PRKCQ | 0.66205698 |
81 | MAP3K2 | 0.66017317 |
82 | YES1 | 0.65392045 |
83 | LATS2 | 0.64610592 |
84 | RPS6KA5 | 0.64439116 |
85 | TNIK | 0.64363691 |
86 | KSR2 | 0.63108646 |
87 | TAOK1 | 0.62971546 |
88 | DAPK1 | 0.62694367 |
89 | FGFR3 | 0.61068151 |
90 | PRKCG | 0.60314594 |
91 | IRAK1 | 0.58985945 |
92 | PIK3CA | 0.56680916 |
93 | CDK3 | 0.51236017 |
94 | STK38L | 0.49972538 |
95 | NME1 | 0.48932906 |
96 | PLK3 | 0.48592819 |
97 | SGK1 | 0.46090754 |
98 | PRKACG | 0.45585924 |
99 | MAP2K1 | 0.45300323 |
100 | PRKAA1 | 0.45130950 |
101 | MAPKAPK3 | 0.44706989 |
102 | FLT3 | 0.44325607 |
103 | MAP3K6 | 0.44212269 |
104 | PRKG2 | 0.43981573 |
105 | RAF1 | 0.42176429 |
106 | TXK | 0.41864416 |
107 | ITK | 0.41066827 |
108 | DYRK1A | 0.40266300 |
109 | MAPK4 | 0.39971766 |
110 | WNK1 | 0.39955741 |
111 | PKN1 | 0.38690987 |
112 | PRKCE | 0.38333288 |
113 | PINK1 | 0.37902437 |
114 | OXSR1 | 0.37848718 |
115 | NLK | 0.37699555 |
116 | BMPR2 | 0.37542295 |
117 | PDK2 | 0.37417368 |
118 | MAP2K6 | 0.36856732 |
119 | SGK3 | 0.36819368 |
120 | AKT3 | 0.36559678 |
121 | TLK1 | 0.36402414 |
122 | ERBB4 | 0.36286503 |
123 | WNK3 | 0.36271064 |
124 | INSRR | 0.36032709 |
125 | MAP3K5 | 0.35852009 |
126 | EPHA3 | 0.35845248 |
127 | PRKACA | 0.35813063 |
128 | MKNK1 | 0.35370226 |
129 | CAMK1 | 0.35038260 |
130 | TNK2 | 0.34751562 |
131 | RPS6KA4 | 0.34455017 |
132 | RIPK4 | 0.32514397 |
133 | PTK2 | 0.32372270 |
134 | * PRKCA | 0.32142239 |
135 | SCYL2 | 0.31221370 |
136 | SGK2 | 0.30839873 |
137 | SGK494 | 0.30723997 |
138 | SGK223 | 0.30723997 |
139 | WEE1 | 0.30352892 |
140 | MAP3K1 | 0.29534922 |
141 | LYN | 0.29382635 |
142 | ERBB3 | 0.28406353 |
143 | IGF1R | 0.26373614 |
144 | STK11 | 0.25585051 |
145 | EIF2AK3 | 0.25583434 |
146 | RPS6KB1 | 0.24586878 |
147 | PRKACB | 0.23933934 |
148 | HIPK2 | 0.23837589 |
149 | * CSNK1G2 | 0.22364798 |
Rank | Gene Set | Z-score |
---|---|---|
1 | * Cocaine addiction_Homo sapiens_hsa05030 | 4.48094148 |
2 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 4.09334255 |
3 | Parkinsons disease_Homo sapiens_hsa05012 | 3.60086582 |
4 | * Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.56909680 |
5 | Tyrosine metabolism_Homo sapiens_hsa00350 | 3.38155847 |
6 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 3.32553752 |
7 | * Amphetamine addiction_Homo sapiens_hsa05031 | 3.24089823 |
8 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.18104485 |
9 | * Serotonergic synapse_Homo sapiens_hsa04726 | 3.07249026 |
10 | * Dopaminergic synapse_Homo sapiens_hsa04728 | 2.83356817 |
11 | Sulfur metabolism_Homo sapiens_hsa00920 | 2.69767303 |
12 | Nicotine addiction_Homo sapiens_hsa05033 | 2.67794597 |
13 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.65493763 |
14 | Circadian rhythm_Homo sapiens_hsa04710 | 2.35567044 |
15 | Histidine metabolism_Homo sapiens_hsa00340 | 2.25770900 |
16 | Cholinergic synapse_Homo sapiens_hsa04725 | 2.25093613 |
17 | Nitrogen metabolism_Homo sapiens_hsa00910 | 2.21839226 |
18 | Alzheimers disease_Homo sapiens_hsa05010 | 2.04723530 |
19 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 2.00743564 |
20 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.90119648 |
21 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.85006475 |
22 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.76360913 |
23 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.73973801 |
24 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.71265119 |
25 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.70906303 |
26 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.68829978 |
27 | Circadian entrainment_Homo sapiens_hsa04713 | 1.66794814 |
28 | GABAergic synapse_Homo sapiens_hsa04727 | 1.65621450 |
29 | Huntingtons disease_Homo sapiens_hsa05016 | 1.57879582 |
30 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.56240944 |
31 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 1.55401904 |
32 | Long-term depression_Homo sapiens_hsa04730 | 1.50888419 |
33 | Taste transduction_Homo sapiens_hsa04742 | 1.42363911 |
34 | * Alcoholism_Homo sapiens_hsa05034 | 1.41173640 |
35 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 1.37396561 |
36 | Morphine addiction_Homo sapiens_hsa05032 | 1.36261182 |
37 | Olfactory transduction_Homo sapiens_hsa04740 | 1.35299930 |
38 | Insulin secretion_Homo sapiens_hsa04911 | 1.30569608 |
39 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.28502048 |
40 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.27479096 |
41 | Salivary secretion_Homo sapiens_hsa04970 | 1.25263031 |
42 | Long-term potentiation_Homo sapiens_hsa04720 | 1.24160307 |
43 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.22700702 |
44 | Gap junction_Homo sapiens_hsa04540 | 1.22188530 |
45 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.20432572 |
46 | Renin secretion_Homo sapiens_hsa04924 | 1.20109049 |
47 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.15230224 |
48 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.11829432 |
49 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.06534899 |
50 | Ribosome_Homo sapiens_hsa03010 | 1.05580249 |
51 | African trypanosomiasis_Homo sapiens_hsa05143 | 1.04846106 |
52 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.03481099 |
53 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 1.02147042 |
54 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.00788396 |
55 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.95066513 |
56 | Proteasome_Homo sapiens_hsa03050 | 0.93484718 |
57 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.93197054 |
58 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.90065791 |
59 | ABC transporters_Homo sapiens_hsa02010 | 0.89616161 |
60 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.87104522 |
61 | Thyroid cancer_Homo sapiens_hsa05216 | 0.86353717 |
62 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.85879970 |
63 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.82563218 |
64 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.82078509 |
65 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.74004390 |
66 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.73669934 |
67 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.72502899 |
68 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.70666678 |
69 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.69706233 |
70 | Asthma_Homo sapiens_hsa05310 | 0.69648772 |
71 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.67686556 |
72 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.67673605 |
73 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.66362850 |
74 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.64282693 |
75 | Protein export_Homo sapiens_hsa03060 | 0.63398409 |
76 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.62210754 |
77 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.62139981 |
78 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.61499041 |
79 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.60864682 |
80 | Peroxisome_Homo sapiens_hsa04146 | 0.60329706 |
81 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.58472087 |
82 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.57773457 |
83 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.55341616 |
84 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.54680670 |
85 | Phagosome_Homo sapiens_hsa04145 | 0.54251624 |
86 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.54186211 |
87 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.52438562 |
88 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.49932362 |
89 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.49667255 |
90 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.48839631 |
91 | Platelet activation_Homo sapiens_hsa04611 | 0.48731536 |
92 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.48375522 |
93 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.47023276 |
94 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.46962869 |
95 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.46931316 |
96 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.46499348 |
97 | Basal transcription factors_Homo sapiens_hsa03022 | 0.44596142 |
98 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.42347660 |
99 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.42019027 |
100 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.41965910 |
101 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.41738026 |
102 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.41151094 |
103 | Melanogenesis_Homo sapiens_hsa04916 | 0.40793333 |
104 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.40184671 |
105 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.39855354 |
106 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.36966175 |
107 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.36870818 |
108 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.36845772 |
109 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.36664558 |
110 | Melanoma_Homo sapiens_hsa05218 | 0.36322538 |
111 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.36027461 |
112 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.35106883 |
113 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.34183575 |
114 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.30886635 |
115 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.28925535 |
116 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.26944083 |
117 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.26349633 |
118 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.25127163 |
119 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.25059323 |
120 | Phototransduction_Homo sapiens_hsa04744 | 0.24414086 |
121 | Metabolic pathways_Homo sapiens_hsa01100 | 0.23084691 |
122 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.20770695 |
123 | Prion diseases_Homo sapiens_hsa05020 | 0.17908742 |
124 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.17606334 |
125 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.17031057 |
126 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.15930519 |
127 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.15864421 |
128 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.15590850 |
129 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.15080990 |
130 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.14571222 |
131 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.14396703 |
132 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.11914428 |
133 | RNA degradation_Homo sapiens_hsa03018 | 0.10838084 |
134 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.10143645 |
135 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.10079501 |
136 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.09621831 |
137 | Purine metabolism_Homo sapiens_hsa00230 | 0.08001377 |