SLC18A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the vesicular amine transporter family. The encoded transmembrane protein transports acetylcholine into secretory vesicles for release into the extracellular space. Acetylcholine transport utilizes a proton gradient established by a vacuolar ATPase. This gene is located within the first intron of the choline acetyltransferase gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuromuscular synaptic transmission (GO:0007274)6.61709610
2enteric nervous system development (GO:0048484)6.43615444
3sympathetic nervous system development (GO:0048485)6.15118400
4positive regulation of fibroblast migration (GO:0010763)5.80672508
5synaptic vesicle maturation (GO:0016188)5.77342335
6intermediate filament organization (GO:0045109)5.49159496
7* neurotransmitter secretion (GO:0007269)5.47475320
8peripheral nervous system neuron development (GO:0048935)5.34384959
9ganglion development (GO:0061548)5.30078890
10neurotransmitter biosynthetic process (GO:0042136)5.14935347
11negative regulation of heart rate (GO:0010459)5.07044726
12neuronal action potential propagation (GO:0019227)5.01835792
13regulation of short-term neuronal synaptic plasticity (GO:0048172)4.81470499
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.78511872
15skeletal muscle organ development (GO:0060538)4.71630112
16respiratory system process (GO:0003016)4.70615026
17axon cargo transport (GO:0008088)4.63129195
18synaptic vesicle exocytosis (GO:0016079)4.60147661
19regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.56629040
20regulation of glomerular filtration (GO:0003093)4.52685922
21pyrimidine nucleobase catabolic process (GO:0006208)4.48412527
22diaphragm development (GO:0060539)4.44718280
23neuromuscular process controlling posture (GO:0050884)4.39287919
24cell migration in hindbrain (GO:0021535)4.37981160
25negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.21415182
26neuron cell-cell adhesion (GO:0007158)4.19370774
27behavioral response to ethanol (GO:0048149)4.16990478
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.14389014
29positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.11900983
30negative regulation of microtubule polymerization (GO:0031115)4.10506586
31regulation of synaptic vesicle exocytosis (GO:2000300)4.10264423
32neurotransmitter metabolic process (GO:0042133)4.08566211
33adult walking behavior (GO:0007628)4.03829954
34regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.02915866
35sequestering of actin monomers (GO:0042989)4.01261090
36synaptic transmission, cholinergic (GO:0007271)3.98800429
37protein localization to synapse (GO:0035418)3.95827827
38motor neuron axon guidance (GO:0008045)3.94686744
39cell communication by electrical coupling (GO:0010644)3.94232292
40glutamate secretion (GO:0014047)3.87884509
41cranial nerve morphogenesis (GO:0021602)3.84862002
42regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.83481514
43regulation of vesicle fusion (GO:0031338)3.82200170
44activation of protein kinase A activity (GO:0034199)3.80408189
45* neurotransmitter transport (GO:0006836)3.79270539
46* regulation of neurotransmitter levels (GO:0001505)3.77602717
47dopaminergic neuron differentiation (GO:0071542)3.77243798
48regulation of circadian sleep/wake cycle, sleep (GO:0045187)3.73088760
49regulation of circadian sleep/wake cycle (GO:0042749)3.73088760
50cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.71397636
51renal system process involved in regulation of blood volume (GO:0001977)3.65395852
52vocalization behavior (GO:0071625)3.65019026
53synaptic vesicle docking involved in exocytosis (GO:0016081)3.64768956
54regulation of cardioblast proliferation (GO:0003264)3.63302936
55regulation of secondary heart field cardioblast proliferation (GO:0003266)3.63302936
56calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.58865974
57response to pheromone (GO:0019236)3.57988365
58startle response (GO:0001964)3.57155476
59type B pancreatic cell development (GO:0003323)3.55558308
60ATP synthesis coupled proton transport (GO:0015986)3.51670976
61energy coupled proton transport, down electrochemical gradient (GO:0015985)3.51670976
62neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.50989376
63regulation of transmission of nerve impulse (GO:0051969)3.48629183
64positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.43844974
65auditory behavior (GO:0031223)3.43510232
66regulation of synaptic vesicle transport (GO:1902803)3.41948125
67regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.41443572
68central nervous system projection neuron axonogenesis (GO:0021952)3.40713249
69membrane hyperpolarization (GO:0060081)3.39902430
70nucleobase catabolic process (GO:0046113)3.38527284
71central nervous system neuron axonogenesis (GO:0021955)3.38310094
72neuromuscular process (GO:0050905)3.38116109
73negative chemotaxis (GO:0050919)3.37759107
74neuron projection extension involved in neuron projection guidance (GO:1902284)3.36573065
75axon extension involved in axon guidance (GO:0048846)3.36573065
76regulation of heart morphogenesis (GO:2000826)3.36127699
77negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.31915727
78establishment of nucleus localization (GO:0040023)3.30718080
79neuromuscular process controlling balance (GO:0050885)3.30640430
80regulation of glutamate receptor signaling pathway (GO:1900449)3.28985977
81regulation of respiratory system process (GO:0044065)3.28572411
82membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.28420814
83intermediate filament cytoskeleton organization (GO:0045104)3.27136134
84positive regulation of transcription regulatory region DNA binding (GO:2000679)3.26237233
85regulation of neuronal synaptic plasticity (GO:0048168)3.25096494
86suckling behavior (GO:0001967)3.22616531
87locomotory exploration behavior (GO:0035641)3.21475446
88dendrite development (GO:0016358)3.20723411
89righting reflex (GO:0060013)3.19436966
90cerebellar Purkinje cell differentiation (GO:0021702)3.19385469
91maternal behavior (GO:0042711)3.19140781
92energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.18907657
93ATP hydrolysis coupled proton transport (GO:0015991)3.18907657
94exploration behavior (GO:0035640)3.18261419
95layer formation in cerebral cortex (GO:0021819)3.15623895
96cell migration involved in heart development (GO:0060973)3.14501361
97intermediate filament-based process (GO:0045103)3.14253260
98regulation of synapse structural plasticity (GO:0051823)3.12456067
99mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.09916942
100renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.09882070
101positive regulation of vesicle fusion (GO:0031340)3.07803938
102neuron recognition (GO:0008038)3.07766877
103circadian sleep/wake cycle process (GO:0022410)3.07379845
104axonal fasciculation (GO:0007413)3.05989947
105calcium-mediated signaling using intracellular calcium source (GO:0035584)3.05199939
106negative regulation of striated muscle cell apoptotic process (GO:0010664)3.04170047
107cartilage morphogenesis (GO:0060536)3.03525784
108presynaptic membrane organization (GO:0097090)3.02752427
109cerebellar Purkinje cell layer development (GO:0021680)3.02574909
110lateral sprouting from an epithelium (GO:0060601)3.02121561
111negative regulation of neurological system process (GO:0031645)3.02022608
112regulation of respiratory gaseous exchange (GO:0043576)3.01394672
113dendrite morphogenesis (GO:0048813)3.00935191
114rhythmic behavior (GO:0007622)2.95925369
115axon extension (GO:0048675)2.95739054
116positive regulation of synapse assembly (GO:0051965)2.95523661
117dendritic spine organization (GO:0097061)2.95460369
118dendritic spine morphogenesis (GO:0060997)2.95083852
119peristalsis (GO:0030432)2.93537986
120ionotropic glutamate receptor signaling pathway (GO:0035235)2.93500923
121cardiac ventricle formation (GO:0003211)2.93138073
122respiratory electron transport chain (GO:0022904)2.92172413
123positive regulation of glomerulus development (GO:0090193)2.90637044
124behavioral response to nicotine (GO:0035095)2.89757163
125regulation of long-term neuronal synaptic plasticity (GO:0048169)2.88375030
126lateral ventricle development (GO:0021670)2.85512533
127regulation of axonogenesis (GO:0050770)2.85357170
128transmission of nerve impulse (GO:0019226)2.85341328
129regulation of vasodilation (GO:0042312)2.83709780
130electron transport chain (GO:0022900)2.83546132
131response to auditory stimulus (GO:0010996)2.83039185
132postsynaptic membrane organization (GO:0001941)2.79704298
133* signal release (GO:0023061)2.79183505
134neuron-neuron synaptic transmission (GO:0007270)2.77284491
135establishment of mitochondrion localization (GO:0051654)2.76415522
136dopamine receptor signaling pathway (GO:0007212)2.75299694
137parental behavior (GO:0060746)2.74376705
138cardiac chamber formation (GO:0003207)2.72821570
139synapse assembly (GO:0007416)2.72674098
140regulation of chemokine-mediated signaling pathway (GO:0070099)2.72257217
141regulation of axon guidance (GO:1902667)2.71428782
142regulation of synaptic transmission, GABAergic (GO:0032228)2.68548919
143body morphogenesis (GO:0010171)2.68412532
144neural crest cell migration (GO:0001755)2.66216344
145dorsal/ventral neural tube patterning (GO:0021904)2.66147003
146innervation (GO:0060384)2.66052455
147glandular epithelial cell development (GO:0002068)2.61794561
148endocardial cushion morphogenesis (GO:0003203)2.60683628
149positive regulation of synaptic transmission, GABAergic (GO:0032230)2.59048395
150negative regulation of axon guidance (GO:1902668)2.56788791
151urinary tract smooth muscle contraction (GO:0014848)2.56328488
152mesenchyme morphogenesis (GO:0072132)2.55534540
153positive regulation of dendritic spine morphogenesis (GO:0061003)2.55319025
154embryonic body morphogenesis (GO:0010172)2.52051284
155catecholamine biosynthetic process (GO:0042423)2.50731055
156catechol-containing compound biosynthetic process (GO:0009713)2.50731055
157response to pain (GO:0048265)2.50306412
158retinal ganglion cell axon guidance (GO:0031290)2.50072008
159cranial nerve development (GO:0021545)2.49535770
160negative regulation of dendrite morphogenesis (GO:0050774)2.49411995
161regulation of axon extension involved in axon guidance (GO:0048841)2.48828854
162camera-type eye morphogenesis (GO:0048593)2.48644679
163neuron fate specification (GO:0048665)2.47975724
164positive regulation of axon extension (GO:0045773)2.47376087
165homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.47044897
166neural crest cell development (GO:0014032)2.45542224
167regulation of dendrite morphogenesis (GO:0048814)2.42857617
168synapse organization (GO:0050808)2.42627601
169neurofilament cytoskeleton organization (GO:0060052)11.6628324

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.80215728
2CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.42858465
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.39119357
4* JARID2_20075857_ChIP-Seq_MESCs_Mouse3.27843121
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.20166334
6* RNF2_18974828_ChIP-Seq_MESCs_Mouse3.07143419
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse3.07143419
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.84931260
9* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.83881375
10* EZH2_27294783_Chip-Seq_ESCs_Mouse2.73258850
11* EZH2_27304074_Chip-Seq_ESCs_Mouse2.69673512
12* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.69227507
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.67498662
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.66147135
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.66008619
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.65604465
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61107091
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.58094803
19* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55286684
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.54892348
21* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.54030771
22GBX2_23144817_ChIP-Seq_PC3_Human2.52675397
23ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.42093232
24ESR1_15608294_ChIP-ChIP_MCF-7_Human2.38887682
25RARB_27405468_Chip-Seq_BRAIN_Mouse2.35204571
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.32898170
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.20108734
28* RNF2_27304074_Chip-Seq_ESCs_Mouse2.19651877
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.16156247
30* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.07027508
31* IKZF1_21737484_ChIP-ChIP_HCT116_Human2.06846077
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.99745695
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.94376528
34DROSHA_22980978_ChIP-Seq_HELA_Human1.90328622
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80183131
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.78635885
37EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.76579739
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72556193
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72392284
40CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.71413159
41KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.67665329
42KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.67665329
43KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.67665329
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.67333820
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.64928177
46* RING1B_27294783_Chip-Seq_ESCs_Mouse1.63877763
47RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.62852465
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.61893904
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.52158992
50DNAJC2_21179169_ChIP-ChIP_NT2_Human1.45780398
51TP53_20018659_ChIP-ChIP_R1E_Mouse1.45495474
52RNF2_27304074_Chip-Seq_NSC_Mouse1.45181405
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41098045
54NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.39837451
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36751122
56ISL1_27105846_Chip-Seq_CPCs_Mouse1.35470224
57KDM2B_26808549_Chip-Seq_K562_Human1.31481189
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30362216
59TAF15_26573619_Chip-Seq_HEK293_Human1.28984661
60WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28340953
61STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28104099
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.26414583
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26384589
64* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25587179
65* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.25211034
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25012469
67CTCF_27219007_Chip-Seq_Bcells_Human1.24962898
68ZNF274_21170338_ChIP-Seq_K562_Hela1.22649331
69HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.19274889
70ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17850564
71* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.17377576
72CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.16266071
73GATA1_26923725_Chip-Seq_HPCs_Mouse1.15281768
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.13711255
75TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12308867
76OCT4_19829295_ChIP-Seq_ESCs_Human1.11463834
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07374378
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06772076
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04734321
80IGF1R_20145208_ChIP-Seq_DFB_Human1.03389378
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00304190
82TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99673798
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97854144
84SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97751035
85POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.97065294
86SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97025136
87TET1_21490601_ChIP-Seq_MESCs_Mouse0.95754852
88SMAD4_21799915_ChIP-Seq_A2780_Human0.93956097
89WT1_19549856_ChIP-ChIP_CCG9911_Human0.93777318
90BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93469350
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93102816
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92776227
93RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91649444
94SOX2_21211035_ChIP-Seq_LN229_Gbm0.91405951
95SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.91320419
96AR_21572438_ChIP-Seq_LNCaP_Human0.89451206
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88966954
98THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88521970
99LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87293828
100NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.87145460
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86784344
102* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.86582273
103SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86382432
104MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85662609
105CREB1_26743006_Chip-Seq_LNCaP_Human0.84964192
106SMAD3_21741376_ChIP-Seq_ESCs_Human0.84753506
107TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.84098413
108* AR_19668381_ChIP-Seq_PC3_Human0.83796463
109ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82463742
110SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80547113
111TBX3_20139965_ChIP-Seq_MESCs_Mouse0.80411152
112TOP2B_26459242_ChIP-Seq_MCF-7_Human0.80100571
113ELK4_26923725_Chip-Seq_MESODERM_Mouse0.79321952
114WT1_25993318_ChIP-Seq_PODOCYTE_Human0.79154424
115RUNX1_26923725_Chip-Seq_HPCs_Mouse0.78985404
116SMAD4_21741376_ChIP-Seq_ESCs_Human0.78574852
117LXR_22292898_ChIP-Seq_THP-1_Human0.78440391
118KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.78268509
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.78144815
120* CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.78095084
121P300_19829295_ChIP-Seq_ESCs_Human0.77672639
122TET1_21451524_ChIP-Seq_MESCs_Mouse0.77634192
123AR_25329375_ChIP-Seq_VCAP_Human0.77531246
124YY1_22570637_ChIP-Seq_MALME-3M_Human0.77079257
125SMAD4_21741376_ChIP-Seq_HESCs_Human0.76494553
126SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.75866240
127SRY_22984422_ChIP-ChIP_TESTIS_Rat0.75141421
128P68_20966046_ChIP-Seq_HELA_Human0.74407748
129YAP1_20516196_ChIP-Seq_MESCs_Mouse0.73744415
130NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.73693542
131* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72695851
132CTCF_18555785_ChIP-Seq_MESCs_Mouse0.72232177
133TRIM28_21343339_ChIP-Seq_HEK293_Human0.71529280

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.22245037
2MP0003880_abnormal_central_pattern4.14791555
3MP0005423_abnormal_somatic_nervous3.99688669
4* MP0003635_abnormal_synaptic_transmissio3.86778686
5MP0009046_muscle_twitch3.29923910
6* MP0000955_abnormal_spinal_cord3.24664880
7MP0004270_analgesia3.19284113
8* MP0002184_abnormal_innervation3.16881519
9* MP0004142_abnormal_muscle_tone3.16183671
10MP0002272_abnormal_nervous_system2.81448558
11MP0002734_abnormal_mechanical_nocicepti2.80191813
12* MP0009745_abnormal_behavioral_response2.77009229
13* MP0002063_abnormal_learning/memory/cond2.69592008
14* MP0002064_seizures2.67695902
15MP0001188_hyperpigmentation2.54230577
16MP0006276_abnormal_autonomic_nervous2.48164283
17MP0002102_abnormal_ear_morphology2.37452155
18MP0001529_abnormal_vocalization2.34059713
19MP0003329_amyloid_beta_deposits2.33897163
20MP0005409_darkened_coat_color2.25499321
21MP0001486_abnormal_startle_reflex2.24003896
22MP0004811_abnormal_neuron_physiology2.21642743
23MP0002572_abnormal_emotion/affect_behav2.13404192
24MP0000778_abnormal_nervous_system2.10732228
25MP0003011_delayed_dark_adaptation2.06681996
26MP0003136_yellow_coat_color2.01151908
27MP0001970_abnormal_pain_threshold1.99412164
28* MP0002882_abnormal_neuron_morphology1.92984390
29MP0008438_abnormal_cutaneous_collagen1.86650832
30MP0003122_maternal_imprinting1.84422041
31MP0002733_abnormal_thermal_nociception1.82266126
32MP0008569_lethality_at_weaning1.81549865
33MP0002909_abnormal_adrenal_gland1.80345122
34MP0001968_abnormal_touch/_nociception1.78831715
35MP0002067_abnormal_sensory_capabilities1.72107495
36MP0000534_abnormal_ureter_morphology1.67983904
37MP0004858_abnormal_nervous_system1.65305477
38MP0000566_synostosis1.64400218
39MP0001177_atelectasis1.64143420
40* MP0002752_abnormal_somatic_nervous1.62331249
41MP0005257_abnormal_intraocular_pressure1.60656526
42* MP0002557_abnormal_social/conspecific_i1.56412072
43MP0005187_abnormal_penis_morphology1.53972308
44MP0005623_abnormal_meninges_morphology1.53911292
45MP0001501_abnormal_sleep_pattern1.51138876
46MP0005386_behavior/neurological_phenoty1.49796534
47MP0004924_abnormal_behavior1.49796534
48* MP0002066_abnormal_motor_capabilities/c1.46280691
49MP0001440_abnormal_grooming_behavior1.43178304
50MP0005503_abnormal_tendon_morphology1.42948766
51MP0000537_abnormal_urethra_morphology1.40918721
52MP0000751_myopathy1.40086792
53MP0002009_preneoplasia1.39971109
54MP0003787_abnormal_imprinting1.39567623
55MP0002229_neurodegeneration1.36652025
56MP0002735_abnormal_chemical_nociception1.35565404
57MP0009053_abnormal_anal_canal1.29012010
58MP0005275_abnormal_skin_tensile1.24928617
59MP0002932_abnormal_joint_morphology1.21451590
60MP0002736_abnormal_nociception_after1.20094877
61MP0010030_abnormal_orbit_morphology1.19096655
62MP0005646_abnormal_pituitary_gland1.17922037
63MP0010368_abnormal_lymphatic_system1.16797214
64MP0009250_abnormal_appendicular_skeleto1.14945018
65MP0000678_abnormal_parathyroid_gland1.14426817
66MP0002152_abnormal_brain_morphology1.14340367
67MP0002822_catalepsy1.13299411
68MP0003567_abnormal_fetal_cardiomyocyte1.11185178
69MP0001943_abnormal_respiration1.09919052
70MP0000604_amyloidosis1.08012183
71MP0003634_abnormal_glial_cell1.07778208
72MP0003385_abnormal_body_wall1.05786056
73MP0005197_abnormal_uvea_morphology1.05743290
74MP0004885_abnormal_endolymph1.05380498
75MP0000049_abnormal_middle_ear1.05148522
76MP0001299_abnormal_eye_distance/1.04899286
77MP0003942_abnormal_urinary_system1.04375348
78MP0002108_abnormal_muscle_morphology1.03811474
79MP0003633_abnormal_nervous_system1.03708609
80MP0003631_nervous_system_phenotype1.02514118
81MP0003121_genomic_imprinting0.99130063
82MP0002751_abnormal_autonomic_nervous0.98536534
83MP0003119_abnormal_digestive_system0.97617133
84MP0000538_abnormal_urinary_bladder0.97472202
85MP0000579_abnormal_nail_morphology0.96971918
86MP0003861_abnormal_nervous_system0.95399630
87MP0003879_abnormal_hair_cell0.89702997
88MP0002282_abnormal_trachea_morphology0.89636937
89MP0001984_abnormal_olfaction0.89550049
90* MP0003948_abnormal_gas_homeostasis0.89218831
91MP0000428_abnormal_craniofacial_morphol0.88301042
92MP0004085_abnormal_heartbeat0.87286051
93MP0003878_abnormal_ear_physiology0.87008675
94MP0005377_hearing/vestibular/ear_phenot0.87008675
95MP0000762_abnormal_tongue_morphology0.85239951
96MP0002638_abnormal_pupillary_reflex0.84584927
97MP0002249_abnormal_larynx_morphology0.84492457
98MP0003283_abnormal_digestive_organ0.83342272
99MP0005551_abnormal_eye_electrophysiolog0.83271441
100MP0003632_abnormal_nervous_system0.81671552
101MP0003755_abnormal_palate_morphology0.81577704
102MP0002697_abnormal_eye_size0.80977719
103MP0000516_abnormal_urinary_system0.79861062
104MP0005367_renal/urinary_system_phenotyp0.79861062
105MP0003937_abnormal_limbs/digits/tail_de0.78918180
106MP0003705_abnormal_hypodermis_morpholog0.78135164
107MP0005499_abnormal_olfactory_system0.77940210
108MP0005394_taste/olfaction_phenotype0.77940210
109MP0001340_abnormal_eyelid_morphology0.77935481
110MP0010386_abnormal_urinary_bladder0.77879489
111MP0001502_abnormal_circadian_rhythm0.77411472
112* MP0002081_perinatal_lethality0.76905132
113MP0009765_abnormal_xenobiotic_induced0.76034212
114MP0002082_postnatal_lethality0.75434314
115MP0010770_preweaning_lethality0.75434314
116MP0002069_abnormal_eating/drinking_beha0.75082840
117MP0005645_abnormal_hypothalamus_physiol0.75055454
118* MP0002269_muscular_atrophy0.74833484
119MP0002116_abnormal_craniofacial_bone0.74794002
120MP0003935_abnormal_craniofacial_develop0.74744537
121MP0002127_abnormal_cardiovascular_syste0.74645602
122MP0000920_abnormal_myelination0.74522910
123MP0010769_abnormal_survival0.71922828
124MP0004742_abnormal_vestibular_system0.71547077
125MP0001905_abnormal_dopamine_level0.71189497
126MP0002277_abnormal_respiratory_mucosa0.70879637
127MP0000631_abnormal_neuroendocrine_gland0.70459056
128MP0003123_paternal_imprinting0.68124214
129MP0010768_mortality/aging0.67386851
130* MP0000759_abnormal_skeletal_muscle0.66225123
131MP0001879_abnormal_lymphatic_vessel0.66213538
132MP0001963_abnormal_hearing_physiology0.64892243
133MP0009780_abnormal_chondrocyte_physiolo0.63666647
134MP0004272_abnormal_basement_membrane0.63656361
135MP0005253_abnormal_eye_physiology0.63463416
136MP0001348_abnormal_lacrimal_gland0.63396866
137MP0005410_abnormal_fertilization0.60720769
138MP0001270_distended_abdomen0.58395651
139MP0006035_abnormal_mitochondrial_morpho0.56615860
140* MP0002114_abnormal_axial_skeleton0.54594707
141MP0001664_abnormal_digestion0.53872568
142MP0004197_abnormal_fetal_growth/weight/0.53586557

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.99826609
2Poor suck (HP:0002033)5.77939319
3Septate vagina (HP:0001153)5.76403392
4Abnormality of the vocal cords (HP:0008777)5.03489644
5Supranuclear gaze palsy (HP:0000605)4.53579704
6Pheochromocytoma (HP:0002666)4.43813377
7Generalized hypotonia (HP:0001290)4.15724443
8Hypothermia (HP:0002045)4.13244176
9Rectovaginal fistula (HP:0000143)4.01376112
10Rectal fistula (HP:0100590)4.01376112
11Ulnar claw (HP:0001178)3.99322725
12Bicornuate uterus (HP:0000813)3.86477261
13Neuroendocrine neoplasm (HP:0100634)3.81062724
14Ankle clonus (HP:0011448)3.71714066
15Aplasia/Hypoplasia of the sacrum (HP:0008517)3.69868919
16Focal seizures (HP:0007359)3.55377124
17Vaginal fistula (HP:0004320)3.55177146
18Intestinal fistula (HP:0100819)3.53823527
19Type 2 muscle fiber atrophy (HP:0003554)3.43763277
20Focal motor seizures (HP:0011153)3.28704278
21Neonatal hypoglycemia (HP:0001998)3.24253311
22Atonic seizures (HP:0010819)3.20510549
23Neoplasm of the peripheral nervous system (HP:0100007)3.19506975
24Progressive cerebellar ataxia (HP:0002073)3.17155306
25Febrile seizures (HP:0002373)3.05667715
26Lower limb asymmetry (HP:0100559)2.98087584
27Failure to thrive in infancy (HP:0001531)2.91417669
28Action tremor (HP:0002345)2.90660231
29Muscle fiber atrophy (HP:0100295)2.89180836
30Exotropia (HP:0000577)2.88433923
31Shallow orbits (HP:0000586)2.85118839
32Fatigable weakness (HP:0003473)2.80802294
33Abnormality of the neuromuscular junction (HP:0003398)2.80802294
34Turricephaly (HP:0000262)2.80737005
35Urinary urgency (HP:0000012)2.72289581
36Progressive external ophthalmoplegia (HP:0000590)2.67390509
37Segmental peripheral demyelination/remyelination (HP:0003481)2.65314261
38Partial agenesis of the corpus callosum (HP:0001338)2.64031353
39Anxiety (HP:0000739)2.63548609
40Abnormality of the corticospinal tract (HP:0002492)2.61431832
41Spastic gait (HP:0002064)2.56257397
42Orthostatic hypotension (HP:0001278)2.55780242
43Hammertoe (HP:0001765)2.53873777
44Bowel diverticulosis (HP:0005222)2.52668958
45Hypercortisolism (HP:0001578)2.52479205
46Amblyopia (HP:0000646)2.49753448
47Visual hallucinations (HP:0002367)2.49170042
48Mutism (HP:0002300)2.48645760
49Torticollis (HP:0000473)2.46564339
50Absence seizures (HP:0002121)2.46120517
51Polyphagia (HP:0002591)2.45622009
52Premature rupture of membranes (HP:0001788)2.45142822
53Epileptic encephalopathy (HP:0200134)2.41278123
54Impaired vibration sensation in the lower limbs (HP:0002166)2.36351035
55Neoplasm of the heart (HP:0100544)2.35002851
56Bulbar palsy (HP:0001283)2.33543359
57Generalized tonic-clonic seizures (HP:0002069)2.33444406
58Asymmetric growth (HP:0100555)2.32795979
59Buphthalmos (HP:0000557)2.30784637
60Depression (HP:0000716)2.27564199
61Abnormality of the lower motor neuron (HP:0002366)2.27522635
62Hypoplastic pelvis (HP:0008839)2.25183059
63Cortical dysplasia (HP:0002539)2.25076188
64Short 4th metacarpal (HP:0010044)2.24886412
65Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.24886412
66Hyperparathyroidism (HP:0000843)2.24497566
67Abnormal eating behavior (HP:0100738)2.21690567
68Germ cell neoplasia (HP:0100728)2.20559186
69Abnormality of the 4th metacarpal (HP:0010012)2.20214462
70Dysdiadochokinesis (HP:0002075)2.16335430
71Broad metatarsal (HP:0001783)2.16190136
72Calcaneovalgus deformity (HP:0001848)2.15286513
73Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.14724877
74Craniofacial dystonia (HP:0012179)2.14592006
75Anal stenosis (HP:0002025)2.14559955
76Decreased motor nerve conduction velocity (HP:0003431)2.14434668
77Incomplete penetrance (HP:0003829)2.14367633
78Occipital encephalocele (HP:0002085)2.12906168
79Abnormality of the calcaneus (HP:0008364)2.12790495
80Thin bony cortex (HP:0002753)2.11994013
81Insomnia (HP:0100785)2.11929134
82Acute necrotizing encephalopathy (HP:0006965)2.11442569
83Abnormal autonomic nervous system physiology (HP:0012332)2.11042269
84Paraplegia (HP:0010550)2.10677705
85Decreased lacrimation (HP:0000633)2.10647626
86Morphological abnormality of the middle ear (HP:0008609)2.09806851
87Hypoplasia of the brainstem (HP:0002365)2.09339980
88Aplasia/Hypoplasia of the brainstem (HP:0007362)2.09339980
89Urinary bladder sphincter dysfunction (HP:0002839)2.09289780
90Abnormality of the phalanges of the hallux (HP:0010057)2.08765145
91Long toe (HP:0010511)2.08561874
92Spastic paraplegia (HP:0001258)2.08224367
93Distal sensory impairment (HP:0002936)2.08008688
94Dialeptic seizures (HP:0011146)2.07506877
95Entropion (HP:0000621)2.07080555
96Hypokinesia (HP:0002375)2.06589995
97Abnormal mitochondria in muscle tissue (HP:0008316)2.06124618
98Heterotopia (HP:0002282)2.05615002
99Dysmetria (HP:0001310)2.05114321
100Severe Myopia (HP:0011003)2.04686949
101Foot dorsiflexor weakness (HP:0009027)2.04459893
102Delayed gross motor development (HP:0002194)2.04066844
103Focal dystonia (HP:0004373)2.01990450
104Impaired pain sensation (HP:0007328)2.01888762
105Abnormality of pain sensation (HP:0010832)2.01888762
106Partial duplication of the phalanx of hand (HP:0009999)2.00714296
107Insidious onset (HP:0003587)1.99076238
108Termporal pattern (HP:0011008)1.99076238
109Soft skin (HP:0000977)1.97642270
110Cutaneous finger syndactyly (HP:0010554)1.97557894
111Agitation (HP:0000713)1.97237008
112Muscle stiffness (HP:0003552)1.95744391
113Ventricular fibrillation (HP:0001663)1.95521459
114Thyroid carcinoma (HP:0002890)1.95446441
115Renal duplication (HP:0000075)1.95265505
116Upper limb muscle weakness (HP:0003484)1.94906530
117Megalencephaly (HP:0001355)1.94188770
118Weak cry (HP:0001612)1.94040995
119Lower limb muscle weakness (HP:0007340)1.93360725
120Slow saccadic eye movements (HP:0000514)1.92688190
121Increased mean platelet volume (HP:0011877)1.92678912
122Abnormality of the musculature of the hand (HP:0001421)1.92478846
123Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.92404904
124Limb dystonia (HP:0002451)1.91864557
125Drooling (HP:0002307)1.91238122
126Adducted thumb (HP:0001181)1.91006855
127Pachygyria (HP:0001302)1.90604831
128Clonus (HP:0002169)1.89673702
129Hypoventilation (HP:0002791)1.89166822
130Amyotrophic lateral sclerosis (HP:0007354)1.89153258
131Mitochondrial inheritance (HP:0001427)1.87737816
132Abnormality of the foot musculature (HP:0001436)1.87421127
133Deformed tarsal bones (HP:0008119)1.85922165
134Progressive macrocephaly (HP:0004481)1.85728146
135Cortical visual impairment (HP:0100704)1.85720518
136Morphological abnormality of the pyramidal tract (HP:0002062)1.83148155
137Pointed chin (HP:0000307)1.82712607
138Fetal akinesia sequence (HP:0001989)1.82418161
139Aqueductal stenosis (HP:0002410)1.82158640
140Abnormality of the metopic suture (HP:0005556)1.82120237
141EEG with generalized epileptiform discharges (HP:0011198)1.81405632
142Truncal ataxia (HP:0002078)1.80171527
143Abnormal social behavior (HP:0012433)1.79555729
144Impaired social interactions (HP:0000735)1.79555729
145Annular pancreas (HP:0001734)1.78786860
146Prominent metopic ridge (HP:0005487)1.78424798
147Epileptiform EEG discharges (HP:0011182)1.76244123
148Hypsarrhythmia (HP:0002521)1.76221187
149Lissencephaly (HP:0001339)1.75818500
150Cutaneous syndactyly (HP:0012725)1.74507386
151Myelomeningocele (HP:0002475)1.73022299
152Midline defect of the nose (HP:0004122)1.71149557
153Disproportionate tall stature (HP:0001519)1.69962124
154Abnormality of the parietal bone (HP:0002696)1.69788924
155Asymmetry of the thorax (HP:0001555)1.69725300
156Hyperacusis (HP:0010780)1.67858155
157Aortic dissection (HP:0002647)1.67068633
158Excessive salivation (HP:0003781)1.65184506
159Renal dysplasia (HP:0000110)1.64093478
160Hypoplasia of the iris (HP:0007676)1.63653428
161Short humerus (HP:0005792)1.63218258
162Aplasia/hypoplasia of the humerus (HP:0006507)1.61175836
163Neuroblastic tumors (HP:0004376)1.60564702
164Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.60564702
165Neuroblastoma (HP:0003006)1.60564702
166Primitive neuroectodermal tumor (HP:0030065)1.60564702
167Bladder diverticulum (HP:0000015)1.60335304

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.43171136
2MINK15.18859682
3STK164.52965510
4LIMK13.49172983
5MAP3K123.25420199
6EPHB22.90510932
7MAP3K92.78731517
8NTRK32.77731338
9MAP3K42.55956143
10EPHA32.28655043
11TESK22.08118349
12IRAK31.94511537
13MAP2K71.93821360
14NTRK21.93442904
15PLK41.89904486
16PRKCG1.81916563
17NEK11.80310597
18MAP2K41.79178107
19LMTK21.68969317
20TESK11.68045054
21PAK61.66178922
22PKN21.64421809
23EPHA41.60878366
24PHKG21.59898169
25PHKG11.59898169
26IRAK21.58504483
27CAMK2G1.56901539
28CASK1.56581768
29PTK21.55002990
30MAPK131.50448975
31LATS21.43670240
32ILK1.39403552
33TRIB31.29719326
34GRK51.28758426
35NME11.28743832
36UHMK11.27817473
37PAK31.25330266
38CDK191.23878593
39DYRK1B1.23063194
40DAPK21.22663863
41CDK51.21037995
42MYLK1.20637365
43CAMKK11.19818454
44PASK1.18826896
45PRKCZ1.18084471
46SRPK11.15837815
47KSR21.15245289
48KSR11.12719084
49DMPK1.07191994
50PKN11.05874616
51WNK11.04182732
52TRIM281.02918655
53SCYL20.99380442
54CAMK2A0.98254214
55DYRK20.97690833
56DAPK10.97625697
57GRK70.96078981
58PRKCE0.94230272
59MATK0.93234948
60PLK20.91220273
61CDK140.90835186
62STK38L0.90401562
63IRAK10.90212368
64CAMK1G0.90133132
65MAP3K110.86388482
66ROCK20.82633551
67TTN0.80652147
68CDK180.80637380
69CDK150.80518736
70PINK10.79843484
71CAMK2B0.79072882
72SGK4940.79047748
73SGK2230.79047748
74CDC42BPA0.78432486
75RET0.78385267
76ALK0.78172999
77STK380.78140556
78MAP4K20.78071043
79ERBB20.77345510
80SIK20.76815178
81PDGFRA0.76323503
82ICK0.75531452
83CSNK1A1L0.75107224
84FES0.73002715
85BCR0.71523670
86MAP3K60.71376196
87NTRK10.70565219
88DYRK30.69998048
89CDK11A0.69986287
90PRKCI0.69074621
91INSRR0.67295707
92DDR20.64279106
93TAOK10.59838010
94FER0.58863674
95PTK60.57926364
96PRKD30.57818465
97CAMKK20.57052746
98ADRBK10.56303495
99CAMK2D0.54699593
100CDK30.53624435
101CSNK1G10.52896808
102WNK30.51762895
103PRPF4B0.51013916
104WNK40.50968116
105PAK20.50811169
106DYRK1A0.50528335
107CSNK1E0.49632108
108FGFR20.49521666
109STK390.46995577
110ERBB30.46139870
111ROCK10.45982093
112RPS6KA20.45932605
113MET0.45534890
114TNIK0.43147190
115PRKCH0.43075973
116CSNK1G20.42390020
117PNCK0.42324674
118TYRO30.41676004
119MTOR0.41410465
120DAPK30.41247200
121BRSK10.41018783
122MARK20.39895705
123CSNK1A10.39117549
124MKNK10.38822327
125MAP2K10.38631808
126SGK20.37997441
127MAPK40.36701010
128PRKCB0.35584954
129PRKG10.35348463
130CSNK1G30.34962202
131SRC0.34316027
132PRKDC0.34013561
133STK110.32632914
134MAPK80.31693161
135IRAK40.31557851
136MUSK0.29433400
137MAP3K20.29351767
138PRKACB0.26569022
139FYN0.26562357
140PRKACA0.26511413
141MAPK90.26142174
142AKT30.24989729
143PRKCD0.23723852

Predicted pathways (KEGG)

RankGene SetZ-score
1* Synaptic vesicle cycle_Homo sapiens_hsa047213.45255335
2Oxidative phosphorylation_Homo sapiens_hsa001902.96262747
3Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.96202624
4Parkinsons disease_Homo sapiens_hsa050122.83215536
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.54134312
6Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050142.37462766
7Nicotine addiction_Homo sapiens_hsa050332.37360454
8* Cholinergic synapse_Homo sapiens_hsa047252.31564368
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.22421737
10Alzheimers disease_Homo sapiens_hsa050102.07776879
11GABAergic synapse_Homo sapiens_hsa047272.04434554
12Olfactory transduction_Homo sapiens_hsa047402.02595953
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.98573051
14Cardiac muscle contraction_Homo sapiens_hsa042601.96120177
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.94911129
16Circadian entrainment_Homo sapiens_hsa047131.87248741
17Collecting duct acid secretion_Homo sapiens_hsa049661.84503899
18Huntingtons disease_Homo sapiens_hsa050161.84321136
19ECM-receptor interaction_Homo sapiens_hsa045121.79311748
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.78452317
21Long-term potentiation_Homo sapiens_hsa047201.76944582
22Dopaminergic synapse_Homo sapiens_hsa047281.75055139
23Vibrio cholerae infection_Homo sapiens_hsa051101.66219064
24Hedgehog signaling pathway_Homo sapiens_hsa043401.64687034
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.63806933
26Amphetamine addiction_Homo sapiens_hsa050311.63447754
27Glutamatergic synapse_Homo sapiens_hsa047241.53654446
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.51723969
29Morphine addiction_Homo sapiens_hsa050321.50648741
30Hippo signaling pathway_Homo sapiens_hsa043901.47641578
31Gap junction_Homo sapiens_hsa045401.45275957
32Insulin secretion_Homo sapiens_hsa049111.38325923
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38294630
34Axon guidance_Homo sapiens_hsa043601.36709295
35Butanoate metabolism_Homo sapiens_hsa006501.34681699
36Cocaine addiction_Homo sapiens_hsa050301.34158388
37Basal cell carcinoma_Homo sapiens_hsa052171.32501019
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.30072881
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22475358
40Gastric acid secretion_Homo sapiens_hsa049711.21279516
41Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.20657134
42Focal adhesion_Homo sapiens_hsa045101.20653013
43Salivary secretion_Homo sapiens_hsa049701.19948887
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15844489
45Oxytocin signaling pathway_Homo sapiens_hsa049211.11038837
46Nitrogen metabolism_Homo sapiens_hsa009101.08835090
47Aldosterone synthesis and secretion_Homo sapiens_hsa049251.04573825
48GnRH signaling pathway_Homo sapiens_hsa049121.04038792
49Colorectal cancer_Homo sapiens_hsa052101.02230249
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01182660
51Serotonergic synapse_Homo sapiens_hsa047260.97536349
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97109633
53TGF-beta signaling pathway_Homo sapiens_hsa043500.96478843
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95547705
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.95289930
56Adherens junction_Homo sapiens_hsa045200.93995285
57Taste transduction_Homo sapiens_hsa047420.93011155
58Phototransduction_Homo sapiens_hsa047440.92652470
59Renin secretion_Homo sapiens_hsa049240.91993759
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.90009293
61Notch signaling pathway_Homo sapiens_hsa043300.88496715
62Glioma_Homo sapiens_hsa052140.87149277
63Calcium signaling pathway_Homo sapiens_hsa040200.87009068
64Tight junction_Homo sapiens_hsa045300.86820856
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86198712
66Oocyte meiosis_Homo sapiens_hsa041140.86102681
67Choline metabolism in cancer_Homo sapiens_hsa052310.86083618
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83906475
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83571764
70Wnt signaling pathway_Homo sapiens_hsa043100.82688034
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82414371
72Long-term depression_Homo sapiens_hsa047300.82333481
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81274372
74Prion diseases_Homo sapiens_hsa050200.76498977
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75940064
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72708733
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72218119
78Protein digestion and absorption_Homo sapiens_hsa049740.70603869
79Pathways in cancer_Homo sapiens_hsa052000.69461409
80ErbB signaling pathway_Homo sapiens_hsa040120.69299921
81cAMP signaling pathway_Homo sapiens_hsa040240.68626156
82Estrogen signaling pathway_Homo sapiens_hsa049150.68540946
83Amoebiasis_Homo sapiens_hsa051460.68142084
84Melanogenesis_Homo sapiens_hsa049160.68088049
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.64357250
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.64285213
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64076940
88Thyroid cancer_Homo sapiens_hsa052160.63648478
89Type II diabetes mellitus_Homo sapiens_hsa049300.63592855
90Platelet activation_Homo sapiens_hsa046110.63404815
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63189618
92MicroRNAs in cancer_Homo sapiens_hsa052060.60194217
93Dilated cardiomyopathy_Homo sapiens_hsa054140.59434414
94Small cell lung cancer_Homo sapiens_hsa052220.59312569
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58795868
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58260959
97Phagosome_Homo sapiens_hsa041450.58071480
98Prolactin signaling pathway_Homo sapiens_hsa049170.56529242
99Basal transcription factors_Homo sapiens_hsa030220.56117032
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55509742
101Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54734589
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53832881
103Proteoglycans in cancer_Homo sapiens_hsa052050.53749065
104Steroid biosynthesis_Homo sapiens_hsa001000.52609465
105Ras signaling pathway_Homo sapiens_hsa040140.52575546
106Alcoholism_Homo sapiens_hsa050340.50301781
107AMPK signaling pathway_Homo sapiens_hsa041520.50058737
108Rap1 signaling pathway_Homo sapiens_hsa040150.49862256
109Bile secretion_Homo sapiens_hsa049760.49388091
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49046758
111Insulin signaling pathway_Homo sapiens_hsa049100.48528616
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.48487101
113Fatty acid elongation_Homo sapiens_hsa000620.48090492
114Pyruvate metabolism_Homo sapiens_hsa006200.47835913
115Chronic myeloid leukemia_Homo sapiens_hsa052200.47134981
116Renal cell carcinoma_Homo sapiens_hsa052110.45506310
117Glucagon signaling pathway_Homo sapiens_hsa049220.45318113
118Endocytosis_Homo sapiens_hsa041440.44224191
119Ovarian steroidogenesis_Homo sapiens_hsa049130.44188929
120Pancreatic cancer_Homo sapiens_hsa052120.43731959
121Melanoma_Homo sapiens_hsa052180.42681846
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40991426
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40688536
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.40030999
125Carbon metabolism_Homo sapiens_hsa012000.39555851
126MAPK signaling pathway_Homo sapiens_hsa040100.39256741
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.37490248
128Non-small cell lung cancer_Homo sapiens_hsa052230.36731319
129Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36358297
130Endometrial cancer_Homo sapiens_hsa052130.36051445
131Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34399941
132Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34188729
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.33718915
134cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33695493

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