SLC18B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein, which has high sequence similarity to rat, xenopus and zebrafish proteins. The protein function is unknown. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanin metabolic process (GO:0006582)9.88678208
2secondary metabolite biosynthetic process (GO:0044550)9.37563056
3proteasome assembly (GO:0043248)4.84434373
4pigment biosynthetic process (GO:0046148)4.78166460
5neuron cell-cell adhesion (GO:0007158)4.31693343
6tyrosine metabolic process (GO:0006570)4.22751896
7limb bud formation (GO:0060174)4.19643585
8presynaptic membrane assembly (GO:0097105)4.17835299
9presynaptic membrane organization (GO:0097090)4.17075482
10cullin deneddylation (GO:0010388)3.92058112
11pigment cell differentiation (GO:0050931)3.91747142
12pigment metabolic process (GO:0042440)3.87872324
13melanocyte differentiation (GO:0030318)3.81859899
14cGMP-mediated signaling (GO:0019934)3.78440291
15IMP biosynthetic process (GO:0006188)3.77522123
16tRNA aminoacylation for protein translation (GO:0006418)3.76332830
17IMP metabolic process (GO:0046040)3.74908007
18tRNA aminoacylation (GO:0043039)3.69915913
19amino acid activation (GO:0043038)3.69915913
20fatty acid elongation (GO:0030497)3.60131678
21central nervous system myelination (GO:0022010)3.58888556
22axon ensheathment in central nervous system (GO:0032291)3.58888556
23nuclear pore complex assembly (GO:0051292)3.56005998
24alpha-linolenic acid metabolic process (GO:0036109)3.55507945
25neuron recognition (GO:0008038)3.54591889
26protein complex localization (GO:0031503)3.54030808
27nuclear pore organization (GO:0006999)3.53893199
28vocalization behavior (GO:0071625)3.47087841
29protein deneddylation (GO:0000338)3.45866240
30non-recombinational repair (GO:0000726)3.44885651
31double-strand break repair via nonhomologous end joining (GO:0006303)3.44885651
32phenol-containing compound biosynthetic process (GO:0046189)3.43974815
33mitotic G2/M transition checkpoint (GO:0044818)3.42184590
34L-serine metabolic process (GO:0006563)3.41797186
35protoporphyrinogen IX metabolic process (GO:0046501)3.41223697
36mitotic G2 DNA damage checkpoint (GO:0007095)3.40886148
37melanosome organization (GO:0032438)3.39241752
38pore complex assembly (GO:0046931)3.37287105
39mitotic spindle checkpoint (GO:0071174)3.35142646
40tricarboxylic acid cycle (GO:0006099)3.35068502
41mitotic metaphase plate congression (GO:0007080)3.31268591
42positive regulation of synapse assembly (GO:0051965)3.30801683
43purine nucleobase biosynthetic process (GO:0009113)3.29819720
44axonal fasciculation (GO:0007413)3.27887412
45negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.27864927
46negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.27864927
47negative regulation of mitotic sister chromatid segregation (GO:0033048)3.27864927
48negative regulation of mitotic sister chromatid separation (GO:2000816)3.27864927
49negative regulation of sister chromatid segregation (GO:0033046)3.27864927
50cerebral cortex radially oriented cell migration (GO:0021799)3.24911330
51negative regulation of chromosome segregation (GO:0051985)3.24336579
52cellular protein complex localization (GO:0034629)3.22688678
53ionotropic glutamate receptor signaling pathway (GO:0035235)3.22040687
54developmental pigmentation (GO:0048066)3.21551203
55spindle checkpoint (GO:0031577)3.21370485
56mitotic spindle assembly checkpoint (GO:0007094)3.18751098
57glutamate receptor signaling pathway (GO:0007215)3.18363045
58RNA-dependent DNA replication (GO:0006278)3.16961052
59spindle assembly checkpoint (GO:0071173)3.16178896
60pigment granule organization (GO:0048753)3.15277828
61negative regulation of synaptic transmission, GABAergic (GO:0032229)3.14866182
62regulation of cofactor metabolic process (GO:0051193)3.14776886
63regulation of coenzyme metabolic process (GO:0051196)3.14776886
64transmission of nerve impulse (GO:0019226)3.13191321
65intra-S DNA damage checkpoint (GO:0031573)3.12087902
66retina layer formation (GO:0010842)3.10932152
67response to methylmercury (GO:0051597)3.09960378
68gamma-aminobutyric acid signaling pathway (GO:0007214)3.08747288
69righting reflex (GO:0060013)3.05727416
70startle response (GO:0001964)3.05635952
71dendritic spine morphogenesis (GO:0060997)3.00667120
72negative regulation of DNA recombination (GO:0045910)2.96670093
73regulation of acyl-CoA biosynthetic process (GO:0050812)2.96313871
74regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.96231854
75regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.94980368
76regulation of sulfur metabolic process (GO:0042762)2.92500556
77protein localization to kinetochore (GO:0034501)2.91754141
78postsynaptic membrane organization (GO:0001941)2.91651924
79protein refolding (GO:0042026)2.91549072
80metaphase plate congression (GO:0051310)2.88578560
81regulation of superoxide anion generation (GO:0032928)2.88020495
82long-chain fatty acid biosynthetic process (GO:0042759)2.86765887
83G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.85780602
84regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.85562846
85regulation of mitotic metaphase/anaphase transition (GO:0030071)2.85562846
86regulation of synapse assembly (GO:0051963)2.84267736
87negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.83412718
88lateral sprouting from an epithelium (GO:0060601)2.82931186
89anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.82750346
90regulation of sister chromatid segregation (GO:0033045)2.81435071
91regulation of mitotic sister chromatid separation (GO:0010965)2.81435071
92regulation of mitotic sister chromatid segregation (GO:0033047)2.81435071
93oxidative phosphorylation (GO:0006119)2.79331069
94polyol transport (GO:0015791)2.77479604
95central nervous system projection neuron axonogenesis (GO:0021952)2.76966613
96one-carbon compound transport (GO:0019755)2.76730191
97negative regulation of receptor-mediated endocytosis (GO:0048261)2.75923551
98CENP-A containing nucleosome assembly (GO:0034080)2.75469890
99hyperosmotic salinity response (GO:0042538)2.74867012
100regulation of chromosome segregation (GO:0051983)2.74564606
101protoporphyrinogen IX biosynthetic process (GO:0006782)2.74501957
102synaptic transmission, glutamatergic (GO:0035249)2.74265361
103neuron-neuron synaptic transmission (GO:0007270)2.74252811
104neuronal action potential propagation (GO:0019227)2.74109627
105protein localization to synapse (GO:0035418)2.71132385
106C4-dicarboxylate transport (GO:0015740)2.70689340
107regulation of timing of cell differentiation (GO:0048505)2.69538617
108response to epinephrine (GO:0071871)2.69383551
109keratinocyte development (GO:0003334)2.69217291
110neuron remodeling (GO:0016322)2.69074017
111regulation of helicase activity (GO:0051095)2.69067864
112porphyrin-containing compound biosynthetic process (GO:0006779)2.68319944
113aspartate family amino acid catabolic process (GO:0009068)2.67888730
114regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.67567676
115regulation of sister chromatid cohesion (GO:0007063)2.65554329
116neurotransmitter uptake (GO:0001504)2.63256850
117telomere maintenance via telomerase (GO:0007004)2.63086937
118kidney morphogenesis (GO:0060993)2.62033347
119establishment of chromosome localization (GO:0051303)2.60222574
120mitotic nuclear envelope disassembly (GO:0007077)2.58463326
121ribosome assembly (GO:0042255)2.57003554
122protein localization to chromosome, centromeric region (GO:0071459)2.56921739
123mitotic sister chromatid segregation (GO:0000070)2.56847712
124regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.56422425
125lysine catabolic process (GO:0006554)2.56045307
126lysine metabolic process (GO:0006553)2.56045307
127melanosome transport (GO:0032402)2.55780575
128positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.55409872
129negative regulation of mitosis (GO:0045839)2.55030209
130chromatin remodeling at centromere (GO:0031055)2.54256726
131positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.54173865
132regulation of mitotic spindle organization (GO:0060236)2.54118709
133negative regulation of ligase activity (GO:0051352)2.52613265
134negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.52613265
135regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.52518477
136negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.52310230
137photoreceptor cell differentiation (GO:0046530)2.52065749
138eye photoreceptor cell differentiation (GO:0001754)2.52065749
139cellular response to epinephrine stimulus (GO:0071872)2.51696671
140inner ear receptor stereocilium organization (GO:0060122)2.51125139
141regulation of translational fidelity (GO:0006450)2.50757275
142osteoclast differentiation (GO:0030316)2.50227776
143retinal ganglion cell axon guidance (GO:0031290)2.49586780
144cranial nerve structural organization (GO:0021604)2.48539164
145neuronal ion channel clustering (GO:0045161)2.46273172
146positive regulation of action potential (GO:0045760)2.46264345
147positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.46237645
148regulation of respiratory gaseous exchange (GO:0043576)2.43731659
149mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.43488468
150regulation of glutamate receptor signaling pathway (GO:1900449)2.42477568
151import into cell (GO:0098657)2.41843523
152calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.41097942
153regulation of respiratory system process (GO:0044065)2.40947323
154regulation of short-term neuronal synaptic plasticity (GO:0048172)2.40404523
155regulation of feeding behavior (GO:0060259)2.40379617
156L-amino acid import (GO:0043092)2.38966490
157cranial nerve morphogenesis (GO:0021602)2.38291403
158serotonin receptor signaling pathway (GO:0007210)2.35260330
159regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.35163010
160negative regulation of axon guidance (GO:1902668)2.34126305
161negative regulation of keratinocyte proliferation (GO:0010839)2.33366534
162positive regulation of meiosis (GO:0045836)2.32793870
163central nervous system neuron axonogenesis (GO:0021955)2.32257996
164dendrite development (GO:0016358)2.31214439
165forebrain neuron differentiation (GO:0021879)2.31165167
166synapse assembly (GO:0007416)2.29909878
167cell differentiation involved in kidney development (GO:0061005)2.29695856
168positive regulation of meiotic cell cycle (GO:0051446)2.29404470
169mesenchymal cell differentiation involved in kidney development (GO:0072161)2.29160244
170mesenchymal cell differentiation involved in renal system development (GO:2001012)2.29160244
171regulation of vesicle fusion (GO:0031338)2.27941208
172oligodendrocyte differentiation (GO:0048709)2.27005895
173negative regulation of neurotransmitter transport (GO:0051589)2.26920963
174sympathetic nervous system development (GO:0048485)2.26628610
175cochlea development (GO:0090102)2.25920434
176auditory receptor cell stereocilium organization (GO:0060088)2.25716650
177reflex (GO:0060004)2.25129144
178opioid receptor signaling pathway (GO:0038003)2.24580920
179regulation of development, heterochronic (GO:0040034)2.24500779
180response to histamine (GO:0034776)2.24460125
181dopamine biosynthetic process (GO:0042416)2.24208144
182regulation of synapse organization (GO:0050807)2.24139288
183regulation of non-canonical Wnt signaling pathway (GO:2000050)2.23633979
184negative regulation of axon extension involved in axon guidance (GO:0048843)2.22328488
185cerebral cortex cell migration (GO:0021795)2.21737803
186membrane hyperpolarization (GO:0060081)2.21413184
187negative regulation of myoblast differentiation (GO:0045662)2.21179801
188extracellular regulation of signal transduction (GO:1900115)2.19424486
189extracellular negative regulation of signal transduction (GO:1900116)2.19424486
190membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.19215373
191mesonephros development (GO:0001823)2.19163171
192regulation of excitatory postsynaptic membrane potential (GO:0060079)2.19162769
193nonmotile primary cilium assembly (GO:0035058)2.19037041
194regulation of pigment cell differentiation (GO:0050932)2.18392651
195glomerulus development (GO:0032835)2.18334407
196kidney mesenchyme development (GO:0072074)2.18135456
197regulation of synaptic transmission, GABAergic (GO:0032228)2.17808156
198negative regulation of protein localization to cell surface (GO:2000009)2.17649769
199regulation of synaptic transmission, glutamatergic (GO:0051966)2.16781945
200melanin biosynthetic process (GO:0042438)10.9564573

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.83799896
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.15548409
3EZH2_22144423_ChIP-Seq_EOC_Human4.01577816
4GBX2_23144817_ChIP-Seq_PC3_Human3.82738177
5GATA1_22025678_ChIP-Seq_K562_Human3.30170579
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.17429562
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.02648899
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.01994842
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.99986061
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.90065429
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.84514866
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.75549000
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.70513982
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.70126511
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.69875446
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.66047094
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.62967183
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.60153271
19PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.58612556
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.54782429
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.53295693
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52273677
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.43518688
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42407857
25EZH2_18974828_ChIP-Seq_MESCs_Mouse2.39647843
26RNF2_18974828_ChIP-Seq_MESCs_Mouse2.39647843
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.36867694
28BMI1_23680149_ChIP-Seq_NPCS_Mouse2.36033663
29JARID2_20075857_ChIP-Seq_MESCs_Mouse2.34362673
30KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.32783951
31ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31652098
32PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.31604889
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.30818275
34NELFA_20434984_ChIP-Seq_ESCs_Mouse2.30713570
35CBX2_27304074_Chip-Seq_ESCs_Mouse2.27396710
36MYC_19030024_ChIP-ChIP_MESCs_Mouse2.25982487
37AR_21909140_ChIP-Seq_LNCAP_Human2.22223032
38DCP1A_22483619_ChIP-Seq_HELA_Human2.21911212
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.19257066
40E2F1_18555785_ChIP-Seq_MESCs_Mouse2.17953976
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15378792
42TAF15_26573619_Chip-Seq_HEK293_Human2.11712407
43MYCN_18555785_ChIP-Seq_MESCs_Mouse2.09362355
44ETS1_20019798_ChIP-Seq_JURKAT_Human2.09116932
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.05107568
46ELF1_17652178_ChIP-ChIP_JURKAT_Human2.04381266
47VDR_23849224_ChIP-Seq_CD4+_Human2.02746295
48MYC_18358816_ChIP-ChIP_MESCs_Mouse2.02631586
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.98761257
50ELK1_19687146_ChIP-ChIP_HELA_Human1.96959926
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.96348727
52TFEB_21752829_ChIP-Seq_HELA_Human1.95428652
53MTF2_20144788_ChIP-Seq_MESCs_Mouse1.95068355
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.93648094
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.93395545
56EZH2_27294783_Chip-Seq_ESCs_Mouse1.92940253
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92571133
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.92300188
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.89645810
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.89128222
61SRF_21415370_ChIP-Seq_HL-1_Mouse1.88134175
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.86319259
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86032020
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85636352
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84044200
66SUZ12_27294783_Chip-Seq_ESCs_Mouse1.83393949
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.83021378
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.82810698
69SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.82613650
70NANOG_18555785_ChIP-Seq_MESCs_Mouse1.82271947
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.81052797
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.80565698
73VDR_22108803_ChIP-Seq_LS180_Human1.80177976
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80171598
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79440729
76P300_19829295_ChIP-Seq_ESCs_Human1.78947838
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.75503297
78MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.72400084
79GABP_19822575_ChIP-Seq_HepG2_Human1.70286208
80RNF2_27304074_Chip-Seq_NSC_Mouse1.69345728
81HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.69005995
82FOXP3_21729870_ChIP-Seq_TREG_Human1.68495196
83AR_21572438_ChIP-Seq_LNCaP_Human1.66858674
84FUS_26573619_Chip-Seq_HEK293_Human1.65549731
85MYC_19079543_ChIP-ChIP_MESCs_Mouse1.65498222
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62899648
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.60406216
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59631066
89SMAD4_21799915_ChIP-Seq_A2780_Human1.58148761
90PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54565569
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54321865
92SMAD_19615063_ChIP-ChIP_OVARY_Human1.52536044
93SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50624274
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49393520
95TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44706407
96REST_21632747_ChIP-Seq_MESCs_Mouse1.44578153
97XRN2_22483619_ChIP-Seq_HELA_Human1.44511402
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43186050
99DROSHA_22980978_ChIP-Seq_HELA_Human1.40926874
100NANOG_18555785_Chip-Seq_ESCs_Mouse1.39882041
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.39856019
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38752311
103SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38121314
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38106342
105FLI1_27457419_Chip-Seq_LIVER_Mouse1.37385503
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37029419
107POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36521681
108SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35619070
109ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35427004
110E2F1_21310950_ChIP-Seq_MCF-7_Human1.35251925
111RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.34255953
112TP53_18474530_ChIP-ChIP_U2OS_Human1.34076974
113PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33338470
114CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.33162607
115ER_23166858_ChIP-Seq_MCF-7_Human1.33041582
116AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30024074
117IGF1R_20145208_ChIP-Seq_DFB_Human1.29865994
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27723342
119E2F1_18555785_Chip-Seq_ESCs_Mouse1.27588584
120ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25809607
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25309591
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25309591
123AR_25329375_ChIP-Seq_VCAP_Human1.25294890
124POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25248153
125ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24690711
126CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.23961585
127TTF2_22483619_ChIP-Seq_HELA_Human1.22897435
128NFE2_27457419_Chip-Seq_LIVER_Mouse1.21789944
129RUNX2_22187159_ChIP-Seq_PCA_Human1.20535742
130P53_22387025_ChIP-Seq_ESCs_Mouse1.20298475
131ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20079784
132ARNT_22903824_ChIP-Seq_MCF-7_Human1.20059201
133SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19596604
134CMYC_18555785_Chip-Seq_ESCs_Mouse1.18924381
135STAT3_23295773_ChIP-Seq_U87_Human1.18899900
136IKZF1_21737484_ChIP-ChIP_HCT116_Human1.18215439
137SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17707053
138AHR_22903824_ChIP-Seq_MCF-7_Human1.15712802
139YY1_21170310_ChIP-Seq_MESCs_Mouse1.14258004
140BCAT_22108803_ChIP-Seq_LS180_Human1.14131271
141NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13617004
142RING1B_27294783_Chip-Seq_ESCs_Mouse1.12741401
143EZH2_27294783_Chip-Seq_NPCs_Mouse1.12406879
144CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.12155847
145EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.11503101
146STAT3_18555785_Chip-Seq_ESCs_Mouse1.11447177
147TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.11332240
148TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10993476
149MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10725393
150TCF4_23295773_ChIP-Seq_U87_Human1.09706407
151ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08918216
152NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08609199
153P300_18555785_Chip-Seq_ESCs_Mouse1.08336702
154TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07614704
155TAL1_26923725_Chip-Seq_HPCs_Mouse1.07171285
156POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07168487
157KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05915674
158NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.05856629
159SOX17_20123909_ChIP-Seq_XEN_Mouse1.05553471
160TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05424290
161RING1B_27294783_Chip-Seq_NPCs_Mouse1.05310043
162EWS_26573619_Chip-Seq_HEK293_Human1.04830076
163HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04683714
164CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04468273
165SOX2_18555785_Chip-Seq_ESCs_Mouse1.04443149
166SOX2_21211035_ChIP-Seq_LN229_Gbm1.04180559
167NMYC_18555785_Chip-Seq_ESCs_Mouse1.02800447
168IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02655438
169MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.02585507
170STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02224259
171CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.02088946
172CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01617395
173SALL4_22934838_ChIP-ChIP_CD34+_Human1.01241664
174CLOCK_20551151_ChIP-Seq_293T_Human1.01197317
175TP53_20018659_ChIP-ChIP_R1E_Mouse0.99899901
176ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99887120
177KDM2B_26808549_Chip-Seq_REH_Human0.99714777
178KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99440884
179RUNX1_27457419_Chip-Seq_LIVER_Mouse0.98685112
180OCT4_18555785_Chip-Seq_ESCs_Mouse0.96912743
181POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96795138
182ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96223221
183E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95980302
184NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.95201685
185CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93137078
186TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.89698246
187BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88958550
188GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88889921
189KDM5A_27292631_Chip-Seq_BREAST_Human0.86970517
190FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.84320462
191EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.82626219
192MYC_18940864_ChIP-ChIP_HL60_Human0.80882347
193SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.80416860
194SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.80416072
195SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.78165711

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation6.34963466
2MP0005408_hypopigmentation5.17591788
3MP0000569_abnormal_digit_pigmentation3.97858036
4MP0005075_abnormal_melanosome_morpholog3.86429309
5MP0003880_abnormal_central_pattern3.37692382
6MP0001188_hyperpigmentation3.28744789
7MP0002095_abnormal_skin_pigmentation3.26478268
8MP0002877_abnormal_melanocyte_morpholog3.09706042
9MP0005174_abnormal_tail_pigmentation2.95911172
10MP0000371_diluted_coat_color2.92819984
11MP0003136_yellow_coat_color2.50534440
12MP0006292_abnormal_olfactory_placode2.46829124
13MP0000566_synostosis2.44113284
14MP0008260_abnormal_autophagy2.42974363
15MP0001486_abnormal_startle_reflex2.42160136
16MP0005171_absent_coat_pigmentation2.38642821
17MP0005409_darkened_coat_color2.34749160
18MP0003806_abnormal_nucleotide_metabolis2.33757334
19MP0001324_abnormal_eye_pigmentation2.22909137
20MP0004859_abnormal_synaptic_plasticity2.20366820
21MP0009745_abnormal_behavioral_response2.19339709
22MP0002102_abnormal_ear_morphology2.19117625
23MP0003635_abnormal_synaptic_transmissio2.12438165
24MP0010094_abnormal_chromosome_stability2.07219533
25MP0005058_abnormal_lysosome_morphology2.01993973
26MP0000778_abnormal_nervous_system2.01770279
27MP0006276_abnormal_autonomic_nervous2.00606162
28MP0004742_abnormal_vestibular_system1.94059059
29MP0009046_muscle_twitch1.93412449
30MP0001968_abnormal_touch/_nociception1.90718980
31MP0003111_abnormal_nucleus_morphology1.89636044
32MP0004270_analgesia1.88115557
33MP0005423_abnormal_somatic_nervous1.87087316
34MP0002572_abnormal_emotion/affect_behav1.86412353
35MP0002064_seizures1.85871360
36MP0002090_abnormal_vision1.85116165
37MP0003656_abnormal_erythrocyte_physiolo1.82325088
38MP0002272_abnormal_nervous_system1.80745101
39MP0002736_abnormal_nociception_after1.78795068
40MP0008057_abnormal_DNA_replication1.75374896
41MP0008058_abnormal_DNA_repair1.74877151
42MP0003693_abnormal_embryo_hatching1.72715698
43MP0002075_abnormal_coat/hair_pigmentati1.71946759
44MP0005645_abnormal_hypothalamus_physiol1.68287940
45MP0002063_abnormal_learning/memory/cond1.67529159
46MP0002734_abnormal_mechanical_nocicepti1.66929486
47MP0001186_pigmentation_phenotype1.63764973
48MP0003690_abnormal_glial_cell1.63506715
49MP0001501_abnormal_sleep_pattern1.61527504
50MP0001440_abnormal_grooming_behavior1.59127990
51MP0004957_abnormal_blastocyst_morpholog1.57476225
52MP0010386_abnormal_urinary_bladder1.57143327
53MP0003186_abnormal_redox_activity1.55537635
54MP0001529_abnormal_vocalization1.53662581
55MP0005646_abnormal_pituitary_gland1.52736567
56MP0004142_abnormal_muscle_tone1.52216759
57MP0002067_abnormal_sensory_capabilities1.51910697
58MP0003938_abnormal_ear_development1.51474109
59MP0000026_abnormal_inner_ear1.51175068
60MP0003077_abnormal_cell_cycle1.49348351
61MP0008932_abnormal_embryonic_tissue1.47266968
62MP0009250_abnormal_appendicular_skeleto1.46217554
63MP0001905_abnormal_dopamine_level1.44991886
64MP0002638_abnormal_pupillary_reflex1.44407383
65MP0005551_abnormal_eye_electrophysiolog1.42949476
66MP0009379_abnormal_foot_pigmentation1.41970111
67MP0002249_abnormal_larynx_morphology1.41023126
68MP0005248_abnormal_Harderian_gland1.40746404
69MP0000631_abnormal_neuroendocrine_gland1.40361234
70MP0002735_abnormal_chemical_nociception1.40102202
71MP0002557_abnormal_social/conspecific_i1.38956970
72MP0002876_abnormal_thyroid_physiology1.38343016
73MP0000462_abnormal_digestive_system1.35861822
74MP0006036_abnormal_mitochondrial_physio1.34623187
75MP0002184_abnormal_innervation1.34586484
76MP0003941_abnormal_skin_development1.32839921
77MP0000049_abnormal_middle_ear1.32149953
78MP0006072_abnormal_retinal_apoptosis1.27021489
79MP0001963_abnormal_hearing_physiology1.26876123
80MP0003122_maternal_imprinting1.26181184
81MP0008007_abnormal_cellular_replicative1.24604931
82MP0004147_increased_porphyrin_level1.23934876
83MP0005379_endocrine/exocrine_gland_phen1.22067716
84MP0001970_abnormal_pain_threshold1.21833572
85MP0000762_abnormal_tongue_morphology1.15804148
86MP0001664_abnormal_digestion1.14452193
87MP0004381_abnormal_hair_follicle1.13902682
88MP0005670_abnormal_white_adipose1.13322533
89MP0003385_abnormal_body_wall1.13192804
90MP0002938_white_spotting1.12853362
91MP0003172_abnormal_lysosome_physiology1.12203338
92MP0002733_abnormal_thermal_nociception1.12131068
93MP0005503_abnormal_tendon_morphology1.11832657
94MP0002752_abnormal_somatic_nervous1.11634989
95MP0001984_abnormal_olfaction1.10531066
96MP0003787_abnormal_imprinting1.10242370
97MP0001177_atelectasis1.06554736
98MP0002882_abnormal_neuron_morphology1.05623156
99MP0004924_abnormal_behavior1.00308458
100MP0005386_behavior/neurological_phenoty1.00308458
101MP0004134_abnormal_chest_morphology0.99288547
102MP0000920_abnormal_myelination0.95160969
103MP0001485_abnormal_pinna_reflex0.94522287
104MP0005499_abnormal_olfactory_system0.94471611
105MP0005394_taste/olfaction_phenotype0.94471611
106MP0000015_abnormal_ear_pigmentation0.92848423
107MP0000538_abnormal_urinary_bladder0.92767292
108MP0002277_abnormal_respiratory_mucosa0.92102932
109MP0000955_abnormal_spinal_cord0.91646982
110MP0008789_abnormal_olfactory_epithelium0.91013848
111MP0002822_catalepsy0.90728234
112MP0005253_abnormal_eye_physiology0.90347616
113MP0001502_abnormal_circadian_rhythm0.88952750
114MP0002066_abnormal_motor_capabilities/c0.87167618
115MP0002233_abnormal_nose_morphology0.86631643
116MP0008004_abnormal_stomach_pH0.86196854
117MP0003755_abnormal_palate_morphology0.85767777
118MP0008995_early_reproductive_senescence0.85004546
119MP0009384_cardiac_valve_regurgitation0.83085433
120MP0006035_abnormal_mitochondrial_morpho0.82984026
121MP0004272_abnormal_basement_membrane0.82451110
122MP0001346_abnormal_lacrimal_gland0.81732207
123MP0002177_abnormal_outer_ear0.81625886
124MP0003937_abnormal_limbs/digits/tail_de0.81485707
125MP0002152_abnormal_brain_morphology0.79673026
126MP0000383_abnormal_hair_follicle0.78846376
127MP0005257_abnormal_intraocular_pressure0.78725517
128MP0000358_abnormal_cell_content/0.76154228
129MP0002116_abnormal_craniofacial_bone0.76117521
130MP0002229_neurodegeneration0.75255459
131MP0008569_lethality_at_weaning0.73439724
132MP0005195_abnormal_posterior_eye0.72623171
133MP0003453_abnormal_keratinocyte_physiol0.71485938
134MP0009780_abnormal_chondrocyte_physiolo0.71056672
135MP0003878_abnormal_ear_physiology0.70289092
136MP0005377_hearing/vestibular/ear_phenot0.70289092
137MP0001730_embryonic_growth_arrest0.69885487
138MP0003718_maternal_effect0.66097835
139MP0000350_abnormal_cell_proliferation0.65149855
140MP0005167_abnormal_blood-brain_barrier0.64421431
141MP0005197_abnormal_uvea_morphology0.63933234
142MP0003634_abnormal_glial_cell0.63429297
143MP0005384_cellular_phenotype0.60166134
144MP0001293_anophthalmia0.59201217
145MP0005391_vision/eye_phenotype0.58366978
146MP0009697_abnormal_copulation0.57499975
147MP0003890_abnormal_embryonic-extraembry0.55558400
148MP0003221_abnormal_cardiomyocyte_apopto0.52241485
149MP0005621_abnormal_cell_physiology0.51826158
150MP0001764_abnormal_homeostasis0.49877035
151MP0000313_abnormal_cell_death0.49617544
152MP0000647_abnormal_sebaceous_gland0.49088177
153MP0000579_abnormal_nail_morphology0.47672604
154MP0006082_CNS_inflammation0.46693507
155MP0003632_abnormal_nervous_system0.45085677
156MP0010234_abnormal_vibrissa_follicle0.42984870
157MP0009764_decreased_sensitivity_to0.42920454
158MP0001697_abnormal_embryo_size0.42323465
159MP0008877_abnormal_DNA_methylation0.41618173
160MP0002080_prenatal_lethality0.41272675
161MP0003303_peritoneal_inflammation0.41156389
162MP0005365_abnormal_bile_salt0.38624631
163MP0009672_abnormal_birth_weight0.35827943
164MP0002092_abnormal_eye_morphology0.34709426
165MP0009763_increased_sensitivity_to0.34606876
166MP0001853_heart_inflammation0.34333507
167MP0005636_abnormal_mineral_homeostasis0.32761270
168MP0002269_muscular_atrophy0.32722609
169MP0001672_abnormal_embryogenesis/_devel0.31545779
170MP0005380_embryogenesis_phenotype0.31545779
171MP0003631_nervous_system_phenotype0.31524817
172MP0002084_abnormal_developmental_patter0.29865878
173MP0003633_abnormal_nervous_system0.29841958
174MP0002332_abnormal_exercise_endurance0.28652172
175MP0004019_abnormal_vitamin_homeostasis0.28522480
176MP0009765_abnormal_xenobiotic_induced0.27953221
177MP0005165_increased_susceptibility_to0.27579239
178MP0005266_abnormal_metabolism0.27546183
179MP0000367_abnormal_coat/_hair0.26575975

Predicted human phenotypes

RankGene SetZ-score
1Blue irides (HP:0000635)5.00814161
2Aplasia/Hypoplasia of the macula (HP:0008059)4.87437328
3Focal motor seizures (HP:0011153)4.87304968
4Hypoplasia of the fovea (HP:0007750)4.82530026
5Aplasia/Hypoplasia of the fovea (HP:0008060)4.82530026
6Ocular albinism (HP:0001107)4.78512116
7Generalized hypopigmentation (HP:0007513)4.70914543
8Iris hypopigmentation (HP:0007730)4.65265571
9Aplasia/Hypoplasia affecting the retina (HP:0008061)4.44274733
10Abnormality of the fovea (HP:0000493)4.42653997
11Abnormal auditory evoked potentials (HP:0006958)4.04176860
12Albinism (HP:0001022)4.02867266
13Febrile seizures (HP:0002373)3.75937754
14Cholecystitis (HP:0001082)3.72742819
15Abnormal gallbladder physiology (HP:0012438)3.72742819
16Hypopigmentation of the fundus (HP:0007894)3.61349899
17Abnormality of glycolysis (HP:0004366)3.57618344
18Degeneration of anterior horn cells (HP:0002398)3.56809239
19Abnormality of the anterior horn cell (HP:0006802)3.56809239
20Premature graying of hair (HP:0002216)3.49757562
21Spastic paraparesis (HP:0002313)3.49549790
22Heterochromia iridis (HP:0001100)3.44118105
23Absent/shortened dynein arms (HP:0200106)3.17133698
24Dynein arm defect of respiratory motile cilia (HP:0012255)3.17133698
25Freckling (HP:0001480)3.16931703
26Increased serum pyruvate (HP:0003542)3.10546369
27Cortical dysplasia (HP:0002539)3.05465878
28Abnormal ciliary motility (HP:0012262)3.02502221
29Peripheral hypomyelination (HP:0007182)2.91521692
30Atonic seizures (HP:0010819)2.87430847
31Abnormality of glycolipid metabolism (HP:0010969)2.83291792
32Abnormality of liposaccharide metabolism (HP:0010968)2.83291792
33Abnormality of glycosphingolipid metabolism (HP:0004343)2.83291792
34Focal seizures (HP:0007359)2.82856500
35Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.80762937
36Hypothermia (HP:0002045)2.67528879
37Upper limb muscle weakness (HP:0003484)2.66270574
38Aplasia cutis congenita (HP:0001057)2.65363713
39Epileptic encephalopathy (HP:0200134)2.60717082
40Aplasia involving bones of the upper limbs (HP:0009823)2.58446002
41Aplasia of the phalanges of the hand (HP:0009802)2.58446002
42Aplasia involving bones of the extremities (HP:0009825)2.58446002
43Paraparesis (HP:0002385)2.57718877
44Hyperventilation (HP:0002883)2.57367098
45Spinal muscular atrophy (HP:0007269)2.56453851
46Sensory axonal neuropathy (HP:0003390)2.53671528
47Cutaneous melanoma (HP:0012056)2.50019849
48Abnormal respiratory motile cilium physiology (HP:0012261)2.49028481
49Insidious onset (HP:0003587)2.48850008
50Termporal pattern (HP:0011008)2.48850008
51Abnormality of the axillary hair (HP:0100134)2.48214477
52Abnormality of secondary sexual hair (HP:0009888)2.48214477
53Rhabdomyosarcoma (HP:0002859)2.47964234
54Cholelithiasis (HP:0001081)2.43134182
55Congenital sensorineural hearing impairment (HP:0008527)2.43074775
56Abnormal respiratory motile cilium morphology (HP:0005938)2.40791992
57Abnormal respiratory epithelium morphology (HP:0012253)2.40791992
58Abnormality of methionine metabolism (HP:0010901)2.33724728
59Septo-optic dysplasia (HP:0100842)2.31880488
60Progressive cerebellar ataxia (HP:0002073)2.30140573
61Atelectasis (HP:0100750)2.27031728
62Morphological abnormality of the middle ear (HP:0008609)2.26740060
63Abnormality of incisor morphology (HP:0011063)2.25339104
64Nasolacrimal duct obstruction (HP:0000579)2.25118324
65Delusions (HP:0000746)2.25009859
66Abnormal gallbladder morphology (HP:0012437)2.24894576
67Parakeratosis (HP:0001036)2.23992155
68Abnormality of the lacrimal duct (HP:0011481)2.22791982
69Sensorimotor neuropathy (HP:0007141)2.22445947
70Degeneration of the lateral corticospinal tracts (HP:0002314)2.21908628
71Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.21908628
72Abnormality of the nasolacrimal system (HP:0000614)2.21339013
73Loss of speech (HP:0002371)2.21204667
74White forelock (HP:0002211)2.19865790
75Exotropia (HP:0000577)2.19663251
76Chronic bronchitis (HP:0004469)2.15660239
77Diaphragmatic weakness (HP:0009113)2.15328902
78Spastic diplegia (HP:0001264)2.12910563
79Medial flaring of the eyebrow (HP:0010747)2.12582903
80Metabolic alkalosis (HP:0200114)2.10278508
81Broad-based gait (HP:0002136)2.09871929
82Cerebral hypomyelination (HP:0006808)2.08895541
83Action tremor (HP:0002345)2.08670609
84Thickened helices (HP:0000391)2.08519798
85Optic nerve hypoplasia (HP:0000609)2.07842419
86Abnormality of the labia minora (HP:0012880)2.07463957
87Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.05660922
88Cupped ear (HP:0000378)2.03424106
89Gait imbalance (HP:0002141)2.03358613
90Chromosomal breakage induced by crosslinking agents (HP:0003221)2.02484092
91Genital tract atresia (HP:0001827)2.01885230
92Abnormal lung lobation (HP:0002101)1.99064544
93Aplasia/Hypoplasia of the lens (HP:0008063)1.98944010
94Vaginal atresia (HP:0000148)1.98467218
95Agnosia (HP:0010524)1.98042995
96Postnatal microcephaly (HP:0005484)1.97953617
97Dialeptic seizures (HP:0011146)1.97711357
98Synostosis involving the elbow (HP:0003938)1.97309801
99Humeroradial synostosis (HP:0003041)1.97309801
100Anophthalmia (HP:0000528)1.97101519
101Absent speech (HP:0001344)1.96702347
102Generalized tonic-clonic seizures (HP:0002069)1.95265853
103Atrophy/Degeneration involving motor neurons (HP:0007373)1.94466580
104Osteomalacia (HP:0002749)1.93917803
105Pancreatic islet-cell hyperplasia (HP:0004510)1.93087442
106Patchy hypopigmentation of hair (HP:0011365)1.91976618
107Alacrima (HP:0000522)1.91600047
108Decreased central vision (HP:0007663)1.91000880
109Nephrogenic diabetes insipidus (HP:0009806)1.90964806
110Concave nail (HP:0001598)1.90688483
111Abnormality of the renal medulla (HP:0100957)1.90485476
112Generalized myoclonic seizures (HP:0002123)1.89621330
113Myelomeningocele (HP:0002475)1.89572292
114Narrow nasal bridge (HP:0000446)1.87802151
115Disinhibition (HP:0000734)1.87732757
116Polyphagia (HP:0002591)1.87011917
117Increased cerebral lipofuscin (HP:0011813)1.86809423
118Congenital primary aphakia (HP:0007707)1.85119825
119Duplication of thumb phalanx (HP:0009942)1.85083796
120Progressive macrocephaly (HP:0004481)1.83445051
121Absence seizures (HP:0002121)1.83138226
122Tubulointerstitial nephritis (HP:0001970)1.82555911
123Acute necrotizing encephalopathy (HP:0006965)1.82531455
124Abnormality of aspartate family amino acid metabolism (HP:0010899)1.81205884
125Stomach cancer (HP:0012126)1.80450280
126Mutism (HP:0002300)1.80305565
127Abnormality of the middle phalanges of the toes (HP:0010183)1.79803421
128Cutaneous finger syndactyly (HP:0010554)1.79592668
129Abnormal biliary tract physiology (HP:0012439)1.78948975
130Bile duct proliferation (HP:0001408)1.78948975
131Aplasia of the musculature (HP:0100854)1.78479055
132Facial cleft (HP:0002006)1.77552158
133Nephronophthisis (HP:0000090)1.77515416
134Hypomagnesemia (HP:0002917)1.76736899
135Oculomotor apraxia (HP:0000657)1.76517963
136Conical tooth (HP:0000698)1.76278670
137Absent eyebrow (HP:0002223)1.74947988
138Partial duplication of thumb phalanx (HP:0009944)1.74377051
139Pheochromocytoma (HP:0002666)1.74246405
140Selective tooth agenesis (HP:0001592)1.74243290
141Dysdiadochokinesis (HP:0002075)1.73590677
142Limb dystonia (HP:0002451)1.73542535
143Abnormal eating behavior (HP:0100738)1.72949380
144Popliteal pterygium (HP:0009756)1.72712792
145Lower limb hyperreflexia (HP:0002395)1.72598687
146Nonprogressive disorder (HP:0003680)1.71492484
147Esotropia (HP:0000565)1.70935582
148Bradycardia (HP:0001662)1.70625187
149Aplasia/Hypoplasia of the tibia (HP:0005772)1.70195360
150Nephroblastoma (Wilms tumor) (HP:0002667)1.69598911
151Midline defect of the nose (HP:0004122)1.69583891
152Decreased lacrimation (HP:0000633)1.68775607
153Optic disc pallor (HP:0000543)1.68325711
154Retinal dysplasia (HP:0007973)1.67969571
155Anomalous pulmonary venous return (HP:0010772)1.67496038
156Male pseudohermaphroditism (HP:0000037)1.67489227
157Abnormality of serum amino acid levels (HP:0003112)1.67481016
158Widely patent fontanelles and sutures (HP:0004492)1.67409047
159Increased circulating renin level (HP:0000848)1.67164197
160Cerebral inclusion bodies (HP:0100314)1.66606976
161Abnormality of molar morphology (HP:0011070)1.65897024
162Abnormality of molar (HP:0011077)1.65897024
163Congenital stationary night blindness (HP:0007642)1.65170056
164Exercise-induced muscle cramps (HP:0003710)1.64853943
165Hemiparesis (HP:0001269)1.64524256
166Median cleft lip (HP:0000161)1.64261558
167Ependymoma (HP:0002888)1.63932127
168Drooling (HP:0002307)1.63566070
169Systemic lupus erythematosus (HP:0002725)1.63509310
170CNS hypomyelination (HP:0003429)1.62468568
171Reticulocytosis (HP:0001923)1.61665400
172Diminished motivation (HP:0000745)1.61232539
173Abnormal autonomic nervous system physiology (HP:0012332)1.59166090
174Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.58261678
175Abnormality of alanine metabolism (HP:0010916)1.58261678
176Hyperalaninemia (HP:0003348)1.58261678
177Apathy (HP:0000741)1.57878063
178Generalized hypopigmentation of hair (HP:0011358)1.57439062
179Abnormality of the astrocytes (HP:0100707)1.57253911
180Astrocytoma (HP:0009592)1.57253911
181Leukodystrophy (HP:0002415)1.56792835
182Neuroendocrine neoplasm (HP:0100634)1.53182327
183Bifid tongue (HP:0010297)1.53168890
184Poor head control (HP:0002421)1.52884233
185Glioma (HP:0009733)1.52623161
186Visual hallucinations (HP:0002367)1.52529084
187Hypoplasia of the iris (HP:0007676)1.51929068
188Posterior subcapsular cataract (HP:0007787)1.50949582
189Athetosis (HP:0002305)1.50159766
190Embryonal renal neoplasm (HP:0011794)1.49712582
191Homocystinuria (HP:0002156)1.49657397
192Abnormality of homocysteine metabolism (HP:0010919)1.49657397
193Dyschromatopsia (HP:0007641)1.49355988

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.65702656
2PDK24.34313232
3TSSK63.88825659
4EIF2AK13.49935279
5WEE13.40479242
6TTK3.26278010
7TNIK3.15439359
8BUB13.12771323
9MARK32.97060129
10NEK12.88220419
11NTRK32.82041830
12EPHA42.62867364
13TRIM282.55975162
14SIK32.51415490
15EIF2AK32.47033042
16BRSK22.42766680
17PLK32.33775950
18MKNK12.22045298
19SRPK12.16805375
20MAP2K72.13357148
21AKT31.99265078
22MARK11.87766875
23GRK71.87502865
24OXSR11.85992837
25MAPK131.82228166
26BMPR1B1.80172807
27BRSK11.77178836
28INSRR1.64950689
29EPHB21.63683249
30STK391.62577619
31PRPF4B1.61685727
32NEK61.56945757
33ERBB31.56556611
34MAP3K41.55793583
35GRK11.51919336
36NTRK21.50803822
37PNCK1.48213657
38CAMK1G1.41898623
39ADRBK21.37404520
40PKN11.36143070
41YES11.32425224
42CDK31.31705927
43EIF2AK21.24189580
44BCR1.23681319
45MST41.22832269
46GRK51.20414694
47PRKCE1.20155821
48CAMKK21.18894705
49MUSK1.17699703
50NME11.17601873
51BMPR21.17268578
52PLK21.16650289
53PLK11.14229998
54FRK1.11868969
55CDC71.11772490
56PIK3CA1.11027590
57CLK11.06548554
58IRAK21.03473632
59WNK31.02688768
60WNK41.02630409
61CAMK2B1.02478968
62CAMK2A1.00799212
63NME20.99925325
64ALK0.98963631
65CAMK1D0.98754291
66CCNB10.98495037
67ATR0.94231631
68TNK20.93277108
69PLK40.92852554
70NUAK10.91018063
71SGK4940.88439514
72SGK2230.88439514
73RAF10.87947815
74FGFR10.87917629
75PBK0.86938181
76ZAK0.84848310
77MAPK150.82923291
78ADRBK10.82825487
79IRAK10.81844466
80FGR0.81322192
81MAP2K40.80162058
82SGK20.78534467
83STK160.78288169
84CDK60.77742112
85UHMK10.75855370
86DDR20.75273484
87KSR20.74769831
88CAMK2D0.73966453
89PRKCG0.72923546
90MAP3K120.72919514
91PAK30.72532390
92MAPKAPK50.72266005
93CDK50.72087471
94IRAK30.71365063
95FER0.70814311
96CSNK1A1L0.70216640
97CSNK1G10.69168943
98DYRK20.68983093
99MKNK20.68481761
100WNK10.66066156
101DYRK1A0.64368371
102SGK10.64204110
103ERBB40.64027389
104FGFR20.62445810
105PAK60.61315633
106FES0.61132630
107PRKG10.60970893
108STK30.60151016
109CAMK10.60104030
110CAMK2G0.57659263
111PRKACA0.57024693
112EPHA30.57002014
113MAP3K90.56739961
114PRKD20.56286993
115MST1R0.56186619
116KSR10.56118610
117LATS10.55493532
118DYRK30.54919190
119TIE10.54814090
120CSNK1G30.54278705
121MYLK0.53836583
122MINK10.53299577
123STK240.52008956
124CDK140.51998575
125PRKAA20.51772850
126MATK0.50954572
127PHKG20.50474932
128PHKG10.50474932
129STK110.50115562
130CDK180.50076167
131DAPK20.49912253
132ATM0.49535569
133CSNK1G20.48653932
134CHEK20.46947916
135MAPK70.46366343
136MARK20.46245180
137NTRK10.45001117
138MAP3K50.44829214
139ROCK20.44407067
140RIPK40.43218863
141MAP2K10.42839739
142CDK150.41742617
143RIPK10.41535469
144BCKDK0.41296828
145AURKB0.40045906
146TYK20.39094810
147CHEK10.38897743
148BLK0.37719685
149STK100.37586026
150CDK11A0.37339605
151MAPK100.37181731
152AKT20.37081187
153BRD40.36604854
154ERBB20.35554736
155PRKD30.35138602
156MAP3K20.34919263
157NLK0.34858862
158CSNK2A10.34370514
159ACVR1B0.33370536
160NEK20.32684564
161EGFR0.29192889
162STK40.26845573
163PAK40.26718510
164CSNK2A20.25191875
165PRKDC0.25144625

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.07049567
2Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.88388355
3Non-homologous end-joining_Homo sapiens_hsa034503.58244114
4Proteasome_Homo sapiens_hsa030503.21667170
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.07389418
6Mismatch repair_Homo sapiens_hsa034302.79520223
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.50373235
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.42490607
9Oxidative phosphorylation_Homo sapiens_hsa001902.36357907
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.29570514
11Taste transduction_Homo sapiens_hsa047422.26914818
12DNA replication_Homo sapiens_hsa030302.26360357
13Propanoate metabolism_Homo sapiens_hsa006402.26067129
14Vitamin B6 metabolism_Homo sapiens_hsa007502.24092561
15Cysteine and methionine metabolism_Homo sapiens_hsa002702.17594887
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.16452390
17Serotonergic synapse_Homo sapiens_hsa047262.10973998
18Glutamatergic synapse_Homo sapiens_hsa047242.07089847
19Morphine addiction_Homo sapiens_hsa050322.04397981
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.01619264
21Pyruvate metabolism_Homo sapiens_hsa006202.01443969
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.00525430
23GABAergic synapse_Homo sapiens_hsa047271.99892835
24Phototransduction_Homo sapiens_hsa047441.93279046
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.91952569
26Axon guidance_Homo sapiens_hsa043601.87694689
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.79008656
28Circadian entrainment_Homo sapiens_hsa047131.77563144
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.71322041
30One carbon pool by folate_Homo sapiens_hsa006701.68578222
31Collecting duct acid secretion_Homo sapiens_hsa049661.68143241
32Carbon metabolism_Homo sapiens_hsa012001.67884157
33Biosynthesis of amino acids_Homo sapiens_hsa012301.66328100
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.65709238
35Alzheimers disease_Homo sapiens_hsa050101.64333726
36Salivary secretion_Homo sapiens_hsa049701.62488603
37Renin secretion_Homo sapiens_hsa049241.58384848
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.57648913
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.56725191
40Cell cycle_Homo sapiens_hsa041101.54897655
41Amphetamine addiction_Homo sapiens_hsa050311.53653310
42Other glycan degradation_Homo sapiens_hsa005111.53440046
43Base excision repair_Homo sapiens_hsa034101.53049121
44Spliceosome_Homo sapiens_hsa030401.51279325
45Long-term depression_Homo sapiens_hsa047301.51138042
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.49677656
47Calcium signaling pathway_Homo sapiens_hsa040201.47959858
48Parkinsons disease_Homo sapiens_hsa050121.45966454
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44961888
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.40761784
51Cocaine addiction_Homo sapiens_hsa050301.39113424
52Cardiac muscle contraction_Homo sapiens_hsa042601.39011789
53Lysosome_Homo sapiens_hsa041421.38453306
54Fatty acid metabolism_Homo sapiens_hsa012121.37852669
55Synaptic vesicle cycle_Homo sapiens_hsa047211.34477074
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.33427325
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.31448360
58Ether lipid metabolism_Homo sapiens_hsa005651.30675268
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.30044455
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29658063
61Olfactory transduction_Homo sapiens_hsa047401.24603407
62Insulin secretion_Homo sapiens_hsa049111.24481895
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.24425787
64Homologous recombination_Homo sapiens_hsa034401.24221718
65Fatty acid biosynthesis_Homo sapiens_hsa000611.22662940
66Dopaminergic synapse_Homo sapiens_hsa047281.20560365
67Hedgehog signaling pathway_Homo sapiens_hsa043401.20338289
68Cholinergic synapse_Homo sapiens_hsa047251.20258276
69RNA transport_Homo sapiens_hsa030131.20063780
70Sphingolipid metabolism_Homo sapiens_hsa006001.18732639
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.18505979
72Arginine and proline metabolism_Homo sapiens_hsa003301.17645335
73Basal cell carcinoma_Homo sapiens_hsa052171.17345803
74Gastric acid secretion_Homo sapiens_hsa049711.17083427
75Sulfur metabolism_Homo sapiens_hsa009201.16378379
76Huntingtons disease_Homo sapiens_hsa050161.15957315
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.14714906
78Fatty acid elongation_Homo sapiens_hsa000621.14600404
79Arachidonic acid metabolism_Homo sapiens_hsa005901.12612229
80Glutathione metabolism_Homo sapiens_hsa004801.08790433
81Long-term potentiation_Homo sapiens_hsa047201.08305759
82beta-Alanine metabolism_Homo sapiens_hsa004101.07018399
83Folate biosynthesis_Homo sapiens_hsa007901.05236592
84Protein digestion and absorption_Homo sapiens_hsa049741.03870999
85cAMP signaling pathway_Homo sapiens_hsa040241.03592482
86Oxytocin signaling pathway_Homo sapiens_hsa049211.02028287
87Mineral absorption_Homo sapiens_hsa049781.01962416
88RNA degradation_Homo sapiens_hsa030180.96744670
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.94892083
90Wnt signaling pathway_Homo sapiens_hsa043100.94065264
91N-Glycan biosynthesis_Homo sapiens_hsa005100.92379694
92Melanogenesis_Homo sapiens_hsa049160.91540639
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.91342758
94Pancreatic secretion_Homo sapiens_hsa049720.91074329
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90896742
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.90496965
97RNA polymerase_Homo sapiens_hsa030200.89707012
98Ovarian steroidogenesis_Homo sapiens_hsa049130.86904543
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.86891525
100Fanconi anemia pathway_Homo sapiens_hsa034600.86860268
101Vitamin digestion and absorption_Homo sapiens_hsa049770.85895592
102Oocyte meiosis_Homo sapiens_hsa041140.84893492
103Nucleotide excision repair_Homo sapiens_hsa034200.82893193
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82695842
105Histidine metabolism_Homo sapiens_hsa003400.80576257
106Legionellosis_Homo sapiens_hsa051340.80417559
107ErbB signaling pathway_Homo sapiens_hsa040120.79715567
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79653350
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79403618
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76077602
111Vibrio cholerae infection_Homo sapiens_hsa051100.75123268
112Rheumatoid arthritis_Homo sapiens_hsa053230.74479630
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73959799
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73370028
115GnRH signaling pathway_Homo sapiens_hsa049120.73017551
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72407625
117Epstein-Barr virus infection_Homo sapiens_hsa051690.71902591
118Gap junction_Homo sapiens_hsa045400.71559022
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71093421
120ECM-receptor interaction_Homo sapiens_hsa045120.70809199
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69803803
122Melanoma_Homo sapiens_hsa052180.69277407
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69082774
124Choline metabolism in cancer_Homo sapiens_hsa052310.67744793
125Purine metabolism_Homo sapiens_hsa002300.66527206
126Linoleic acid metabolism_Homo sapiens_hsa005910.66336786
127Ras signaling pathway_Homo sapiens_hsa040140.66125093
128Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65083251
129Metabolic pathways_Homo sapiens_hsa011000.63714754
130Peroxisome_Homo sapiens_hsa041460.63348337
131Dilated cardiomyopathy_Homo sapiens_hsa054140.62704631
132Pyrimidine metabolism_Homo sapiens_hsa002400.61860940
133Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61699166
134Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61186482
135Basal transcription factors_Homo sapiens_hsa030220.60185998
136Steroid biosynthesis_Homo sapiens_hsa001000.59096648
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58309253
138Pentose phosphate pathway_Homo sapiens_hsa000300.53071221
139Staphylococcus aureus infection_Homo sapiens_hsa051500.52808442
140Autoimmune thyroid disease_Homo sapiens_hsa053200.51623545
141Herpes simplex infection_Homo sapiens_hsa051680.50130865
142Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49376778
143Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48565084
144African trypanosomiasis_Homo sapiens_hsa051430.48320363
145Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48142491
146Phospholipase D signaling pathway_Homo sapiens_hsa040720.47875636
147Fatty acid degradation_Homo sapiens_hsa000710.47035569
148mRNA surveillance pathway_Homo sapiens_hsa030150.45180267
149Maturity onset diabetes of the young_Homo sapiens_hsa049500.44251169
150Type II diabetes mellitus_Homo sapiens_hsa049300.44000698
151SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43772406
152Regulation of autophagy_Homo sapiens_hsa041400.43057419
153Steroid hormone biosynthesis_Homo sapiens_hsa001400.42560853
154Butanoate metabolism_Homo sapiens_hsa006500.42371079
155Phagosome_Homo sapiens_hsa041450.41322129
156Adherens junction_Homo sapiens_hsa045200.41151086
157Antigen processing and presentation_Homo sapiens_hsa046120.41061023
158MAPK signaling pathway_Homo sapiens_hsa040100.40928588
159Lysine degradation_Homo sapiens_hsa003100.40808562
160Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39518124
161Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38838994
162Rap1 signaling pathway_Homo sapiens_hsa040150.38060104
163Selenocompound metabolism_Homo sapiens_hsa004500.36244113
164Glycerophospholipid metabolism_Homo sapiens_hsa005640.35113533
165Circadian rhythm_Homo sapiens_hsa047100.35005771
166Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34772765
167Dorso-ventral axis formation_Homo sapiens_hsa043200.34511378
168Tight junction_Homo sapiens_hsa045300.34431614
169Tyrosine metabolism_Homo sapiens_hsa003500.33926998
170Glycerolipid metabolism_Homo sapiens_hsa005610.33648779
171Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33408956
172Protein export_Homo sapiens_hsa030600.32836286
173p53 signaling pathway_Homo sapiens_hsa041150.31198512
174Influenza A_Homo sapiens_hsa051640.29036094
175Galactose metabolism_Homo sapiens_hsa000520.26161482
176Tuberculosis_Homo sapiens_hsa051520.22601421
177Nitrogen metabolism_Homo sapiens_hsa009100.22223134
178Cyanoamino acid metabolism_Homo sapiens_hsa004600.21833425
179Glycosaminoglycan degradation_Homo sapiens_hsa005310.21444181
180Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20691363
181Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.18411914

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