SLC19A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The membrane protein encoded by this gene is a transporter of folate and is involved in the regulation of intracellular concentrations of folate. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.83313058
2DNA strand elongation involved in DNA replication (GO:0006271)4.79539335
3IMP biosynthetic process (GO:0006188)4.77984641
4folic acid-containing compound biosynthetic process (GO:0009396)4.74767065
5nucleobase biosynthetic process (GO:0046112)4.73161760
6DNA deamination (GO:0045006)4.70923382
7positive regulation by symbiont of host defense response (GO:0052509)4.63165396
8modulation by symbiont of host defense response (GO:0052031)4.63165396
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.63165396
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.63165396
11positive regulation by organism of defense response of other organism involved in symbiotic interact4.63165396
12modulation by symbiont of host immune response (GO:0052553)4.63165396
13DNA strand elongation (GO:0022616)4.59191786
14maturation of SSU-rRNA (GO:0030490)4.53524208
15viral transcription (GO:0019083)4.48141059
16translational termination (GO:0006415)4.45279798
17telomere maintenance via semi-conservative replication (GO:0032201)4.42651427
18DNA unwinding involved in DNA replication (GO:0006268)4.42153776
19formation of translation preinitiation complex (GO:0001731)4.41063430
20translational elongation (GO:0006414)4.13036082
21IMP metabolic process (GO:0046040)4.10132036
22DNA replication initiation (GO:0006270)4.10121042
23purine nucleobase biosynthetic process (GO:0009113)3.99468461
24SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.86271814
25response to peptidoglycan (GO:0032494)3.83390450
26ribosomal small subunit biogenesis (GO:0042274)3.82477056
27translational initiation (GO:0006413)3.82160920
28pseudouridine synthesis (GO:0001522)3.80803513
29ribosomal large subunit biogenesis (GO:0042273)3.80093766
30ribosome biogenesis (GO:0042254)3.77021182
31ribonucleoprotein complex biogenesis (GO:0022613)3.73768702
32cotranslational protein targeting to membrane (GO:0006613)3.73678257
33protein targeting to ER (GO:0045047)3.72845788
34nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.72504133
35telomere maintenance via recombination (GO:0000722)3.67510133
36leukocyte migration involved in inflammatory response (GO:0002523)3.67101403
37negative regulation of phagocytosis (GO:0050765)3.54895720
38protein localization to kinetochore (GO:0034501)3.54851668
39mitotic nuclear envelope disassembly (GO:0007077)3.53432428
40DNA topological change (GO:0006265)3.53164075
41establishment of protein localization to endoplasmic reticulum (GO:0072599)3.52364414
42protein localization to endoplasmic reticulum (GO:0070972)3.50973629
43* folic acid metabolic process (GO:0046655)3.50924117
44respiratory burst (GO:0045730)3.48927966
45rRNA processing (GO:0006364)3.48535582
46viral life cycle (GO:0019058)3.46602593
47cellular protein complex disassembly (GO:0043624)3.44410987
48pteridine-containing compound biosynthetic process (GO:0042559)3.34490525
49rRNA metabolic process (GO:0016072)3.33520096
50mitotic recombination (GO:0006312)3.32940177
51telomere maintenance via telomere lengthening (GO:0010833)3.31751841
52leukocyte aggregation (GO:0070486)3.30391704
53positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.30101938
54negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.28688294
55tetrahydrofolate metabolic process (GO:0046653)3.28489640
56detection of other organism (GO:0098543)3.28482902
57nuclear envelope disassembly (GO:0051081)3.25864828
58membrane disassembly (GO:0030397)3.25864828
59negative regulation of RNA splicing (GO:0033119)3.23705186
60detection of bacterium (GO:0016045)3.23131878
61ribosome assembly (GO:0042255)3.16435089
62L-serine metabolic process (GO:0006563)3.12754331
63nucleotide-excision repair, DNA gap filling (GO:0006297)3.12316400
64cellular extravasation (GO:0045123)3.12063882
65DNA replication checkpoint (GO:0000076)3.11811041
66antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.11743985
673-UTR-mediated mRNA stabilization (GO:0070935)3.11011080
68protein complex disassembly (GO:0043241)3.10512740
69negative regulation of B cell apoptotic process (GO:0002903)3.07364652
70pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.06332211
71deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.05906254
72negative regulation of cell killing (GO:0031342)3.05800169
73negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.05800169
74response to host immune response (GO:0052572)3.05314017
75response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.05314017
76apoptotic process involved in morphogenesis (GO:0060561)3.04987301
77tRNA methylation (GO:0030488)3.04001276
78nuclear-transcribed mRNA catabolic process (GO:0000956)3.03441824
79spliceosomal snRNP assembly (GO:0000387)3.00422006
80mitotic chromosome condensation (GO:0007076)3.00248412
81NADPH regeneration (GO:0006740)2.99549676
82antigen processing and presentation of endogenous antigen (GO:0019883)2.99394021
83* folic acid-containing compound metabolic process (GO:0006760)2.98617562
84regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.96627620
85detection of external biotic stimulus (GO:0098581)2.96572517
86regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.96525651
87heterochromatin organization (GO:0070828)2.96476985
88negative regulation of erythrocyte differentiation (GO:0045647)2.95802537
89pentose metabolic process (GO:0019321)2.95611113
90protein localization to chromosome, centromeric region (GO:0071459)2.94640181
91translation (GO:0006412)2.94548429
92detection of molecule of bacterial origin (GO:0032490)2.94498557
93macromolecular complex disassembly (GO:0032984)2.91637792
94intracellular estrogen receptor signaling pathway (GO:0030520)2.91274870
95maternal placenta development (GO:0001893)2.90772472
96mRNA catabolic process (GO:0006402)2.89972687
97cellular component biogenesis (GO:0044085)2.89265959
98serine family amino acid biosynthetic process (GO:0009070)2.88992908
99pentose-phosphate shunt (GO:0006098)2.87458725
100RNA catabolic process (GO:0006401)2.86882346
101response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.86336961
102response to host (GO:0075136)2.86336961
103response to host defenses (GO:0052200)2.86336961
104pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.83972860
105tRNA aminoacylation for protein translation (GO:0006418)2.83520573
106DNA duplex unwinding (GO:0032508)2.82678106
107neutrophil activation involved in immune response (GO:0002283)2.81833916
108regulation of chromatin binding (GO:0035561)2.80921025
109establishment of integrated proviral latency (GO:0075713)2.80480261
110antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.79839029
111antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.79839029
112modulation by virus of host process (GO:0019054)2.78100351
113DNA geometric change (GO:0032392)2.77242403
114amino acid activation (GO:0043038)2.77165885
115tRNA aminoacylation (GO:0043039)2.77165885
116macrophage activation involved in immune response (GO:0002281)2.77103559
117regulation of mitochondrial translation (GO:0070129)2.74780768
118detection of biotic stimulus (GO:0009595)2.70590330
119ncRNA processing (GO:0034470)2.69356668
120nuclear pore organization (GO:0006999)2.68874383
121base-excision repair (GO:0006284)2.68131704
122DNA replication-dependent nucleosome assembly (GO:0006335)2.68073449
123DNA replication-dependent nucleosome organization (GO:0034723)2.68073449
124proteasome assembly (GO:0043248)2.67611126
125CENP-A containing nucleosome assembly (GO:0034080)2.67414194
126definitive hemopoiesis (GO:0060216)2.67330368
127regulation of interferon-beta biosynthetic process (GO:0045357)2.66710084
128regulation of translational fidelity (GO:0006450)2.65915923
129viral mRNA export from host cell nucleus (GO:0046784)2.65851943
130proline biosynthetic process (GO:0006561)2.64632705
131regulation of translational termination (GO:0006449)2.64259037
132pantothenate metabolic process (GO:0015939)2.63446460
133regulation of superoxide anion generation (GO:0032928)2.62451473
134* pteridine-containing compound metabolic process (GO:0042558)2.62086037
135negative regulation of mRNA processing (GO:0050686)2.61024226
136mitochondrial RNA metabolic process (GO:0000959)2.60255708
137one-carbon metabolic process (GO:0006730)2.58608789
138pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.58280463
139UMP biosynthetic process (GO:0006222)2.58280463
140pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.58280463
141UMP metabolic process (GO:0046049)2.58280463
142epithelial cell differentiation involved in prostate gland development (GO:0060742)2.58194018
143peptidyl-arginine omega-N-methylation (GO:0035247)2.57278922
144nuclear pore complex assembly (GO:0051292)2.57227850
145positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.56890213
146chromatin remodeling at centromere (GO:0031055)2.56848217
147DNA replication-independent nucleosome organization (GO:0034724)2.56622895
148DNA replication-independent nucleosome assembly (GO:0006336)2.56622895
149positive regulation of gamma-delta T cell activation (GO:0046645)2.56434044
150ncRNA metabolic process (GO:0034660)2.55034461
151regulation of mammary gland epithelial cell proliferation (GO:0033599)2.54515352
152glucose catabolic process (GO:0006007)2.53067362
153peptidyl-arginine N-methylation (GO:0035246)2.52677876
154peptidyl-arginine methylation (GO:0018216)2.52677876
155rRNA transcription (GO:0009303)2.47755232
156positive regulation of Cdc42 GTPase activity (GO:0043089)2.47348999
157histone arginine methylation (GO:0034969)2.46014687
158nucleosome disassembly (GO:0006337)2.45971798
159protein-DNA complex disassembly (GO:0032986)2.45971798
160pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.42343379
161cellular protein complex localization (GO:0034629)2.40889229
162cellular response to interleukin-4 (GO:0071353)2.39641245
163negative regulation of mRNA metabolic process (GO:1903312)2.39294519

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.59548533
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.51007494
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.30526441
4E2F4_17652178_ChIP-ChIP_JURKAT_Human2.89823725
5* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83918766
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.74733484
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.66641749
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.63518415
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.61362503
10MYC_22102868_ChIP-Seq_BL_Human2.60673572
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.58002623
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.57337894
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.42353931
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.40263468
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.38356882
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.33414400
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.28574140
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.27904433
19XRN2_22483619_ChIP-Seq_HELA_Human2.26917104
20* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.26395447
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.22261522
22TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.08749366
23VDR_23849224_ChIP-Seq_CD4+_Human2.07099655
24* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02254261
25FOXP3_21729870_ChIP-Seq_TREG_Human2.00413424
26* LXR_22292898_ChIP-Seq_THP-1_Human1.89489309
27AR_21909140_ChIP-Seq_LNCAP_Human1.87637148
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.87413259
29DCP1A_22483619_ChIP-Seq_HELA_Human1.85990019
30CIITA_25753668_ChIP-Seq_RAJI_Human1.84360829
31GABP_19822575_ChIP-Seq_HepG2_Human1.84094414
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81959272
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.80832571
34* VDR_21846776_ChIP-Seq_THP-1_Human1.78932622
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.76223086
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.74689249
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.72915347
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.70429778
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.68178240
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68160279
41TTF2_22483619_ChIP-Seq_HELA_Human1.64830950
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63504456
43SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.62488832
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61435406
45* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60166081
46* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57892779
47TCF7_22412390_ChIP-Seq_EML_Mouse1.57389008
48SCL_19346495_ChIP-Seq_HPC-7_Human1.56804405
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56800290
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56756517
51* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.56066423
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.55515533
53RACK7_27058665_Chip-Seq_MCF-7_Human1.53754598
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.52584286
55* KDM2B_26808549_Chip-Seq_DND41_Human1.51818786
56HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50917358
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.46346318
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.45962480
59KDM5A_27292631_Chip-Seq_BREAST_Human1.44205064
60MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.43741699
61TET1_21451524_ChIP-Seq_MESCs_Mouse1.35941562
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35721807
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34007225
64P68_20966046_ChIP-Seq_HELA_Human1.33553038
65MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.33217821
66* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33122479
67RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.31355727
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.30726479
69ELK1_19687146_ChIP-ChIP_HELA_Human1.28405137
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.27759582
71* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27697326
72YY1_21170310_ChIP-Seq_MESCs_Mouse1.27449195
73SA1_27219007_Chip-Seq_ERYTHROID_Human1.26065253
74SPI1_23547873_ChIP-Seq_NB4_Human1.26048289
75CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.24571695
76BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23822822
77MYB_21317192_ChIP-Seq_ERMYB_Mouse1.22702164
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22658949
79NCOR1_26117541_ChIP-Seq_K562_Human1.21869867
80POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21813061
81MAF_26560356_Chip-Seq_TH1_Human1.19866552
82TFEB_21752829_ChIP-Seq_HELA_Human1.19685024
83PU.1_20513432_ChIP-Seq_Bcells_Mouse1.19536406
84SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.18609889
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17885998
86CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17832271
87STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17201469
88GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17136679
89IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.16019451
90E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16019287
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15044994
92ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14541941
93E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13706878
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13276442
95ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.12675208
96UTX_26944678_Chip-Seq_JUKART_Human1.11534741
97IRF8_22096565_ChIP-ChIP_GC-B_Human1.10269401
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10156109
99ELF1_20517297_ChIP-Seq_JURKAT_Human1.10035670
100MYB_26560356_Chip-Seq_TH1_Human1.08489870
101CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08216964
102RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07920161
103SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.07791808
104NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07375999
105STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06633683
106E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05309274
107CTCF_26484167_Chip-Seq_Bcells_Mouse1.04757777
108KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04423937
109NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04420312
110RUNX1_22412390_ChIP-Seq_EML_Mouse1.03629536
111BCOR_27268052_Chip-Seq_Bcells_Human1.03025639
112BCL6_27268052_Chip-Seq_Bcells_Human1.03015671
113MYB_26560356_Chip-Seq_TH2_Human1.02372805
114FOXP1_21924763_ChIP-Seq_HESCs_Human1.01960669
115PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01894274
116CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01386590
117PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00441361
118MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.98885493
119CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98285759
120MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97673095
121* VDR_24763502_ChIP-Seq_THP-1_Human0.96665054
122PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.96658040
123TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95142178
124CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95005866
125STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.94960893
126PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94657160
127MYC_18940864_ChIP-ChIP_HL60_Human0.94513821
128MAF_26560356_Chip-Seq_TH2_Human0.93604417
129BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93198622
130* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88979320
131DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88625024
132CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88235059
133GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87960053

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.21814960
2* MP0002396_abnormal_hematopoietic_system3.43572708
3MP0010094_abnormal_chromosome_stability3.28507644
4MP0004957_abnormal_blastocyst_morpholog3.23233901
5MP0003111_abnormal_nucleus_morphology3.08944964
6MP0006054_spinal_hemorrhage3.06294010
7MP0003077_abnormal_cell_cycle2.82710651
8MP0003763_abnormal_thymus_physiology2.66861447
9MP0004147_increased_porphyrin_level2.64146115
10MP0008057_abnormal_DNA_replication2.51793415
11MP0005451_abnormal_body_composition2.50705200
12MP0008260_abnormal_autophagy2.48012335
13MP0008058_abnormal_DNA_repair2.41082374
14MP0005076_abnormal_cell_differentiation2.31605958
15MP0009333_abnormal_splenocyte_physiolog2.28282879
16* MP0000490_abnormal_crypts_of2.26271054
17MP0004808_abnormal_hematopoietic_stem2.20614960
18MP0008007_abnormal_cellular_replicative2.15616875
19MP0003303_peritoneal_inflammation2.11539496
20MP0005360_urolithiasis2.04650569
21MP0001853_heart_inflammation2.04611528
22MP0003806_abnormal_nucleotide_metabolis2.01464044
23* MP0002398_abnormal_bone_marrow1.99300097
24MP0005397_hematopoietic_system_phenotyp1.94687841
25MP0001545_abnormal_hematopoietic_system1.94687841
26MP0010030_abnormal_orbit_morphology1.93506440
27MP0002249_abnormal_larynx_morphology1.89415923
28MP0003656_abnormal_erythrocyte_physiolo1.82736049
29MP0003705_abnormal_hypodermis_morpholog1.82712120
30MP0000537_abnormal_urethra_morphology1.81716035
31* MP0000689_abnormal_spleen_morphology1.79794563
32* MP0002722_abnormal_immune_system1.79683727
33MP0010352_gastrointestinal_tract_polyps1.79412432
34MP0004185_abnormal_adipocyte_glucose1.79257798
35MP0002277_abnormal_respiratory_mucosa1.78154180
36MP0003186_abnormal_redox_activity1.72895437
37MP0000465_gastrointestinal_hemorrhage1.70218745
38* MP0000703_abnormal_thymus_morphology1.65787805
39MP0000685_abnormal_immune_system1.62513531
40* MP0002429_abnormal_blood_cell1.56895137
41MP0001873_stomach_inflammation1.56499473
42MP0003191_abnormal_cellular_cholesterol1.55071867
43MP0002089_abnormal_postnatal_growth/wei1.54749804
44MP0001835_abnormal_antigen_presentation1.53491395
45MP0006292_abnormal_olfactory_placode1.52719960
46MP0004381_abnormal_hair_follicle1.51928649
47MP0005671_abnormal_response_to1.51313469
48MP0003866_abnormal_defecation1.50271561
49MP0001730_embryonic_growth_arrest1.49486711
50MP0000350_abnormal_cell_proliferation1.48690760
51MP0001800_abnormal_humoral_immune1.48107304
52MP0002019_abnormal_tumor_incidence1.46363172
53MP0003436_decreased_susceptibility_to1.46108572
54* MP0000716_abnormal_immune_system1.45104622
55MP0008932_abnormal_embryonic_tissue1.43561407
56MP0002166_altered_tumor_susceptibility1.40152483
57MP0000678_abnormal_parathyroid_gland1.37209219
58MP0002420_abnormal_adaptive_immunity1.36533072
59MP0003300_gastrointestinal_ulcer1.36410788
60MP0000313_abnormal_cell_death1.36293778
61MP0004858_abnormal_nervous_system1.35880167
62MP0005464_abnormal_platelet_physiology1.33741416
63MP0010155_abnormal_intestine_physiology1.32840385
64MP0001819_abnormal_immune_cell1.32722906
65MP0003315_abnormal_perineum_morphology1.31749268
66MP0002723_abnormal_immune_serum1.29151448
67MP0002405_respiratory_system_inflammati1.29096399
68MP0002452_abnormal_antigen_presenting1.25888509
69MP0001849_ear_inflammation1.23154054
70MP0006035_abnormal_mitochondrial_morpho1.20416595
71MP0005174_abnormal_tail_pigmentation1.16551206
72MP0005075_abnormal_melanosome_morpholog1.15462465
73* MP0002080_prenatal_lethality1.15243340
74MP0005000_abnormal_immune_tolerance1.14580096
75MP0005377_hearing/vestibular/ear_phenot1.13614785
76MP0003878_abnormal_ear_physiology1.13614785
77MP0009643_abnormal_urine_homeostasis1.13394945
78MP0006036_abnormal_mitochondrial_physio1.12855845
79MP0009785_altered_susceptibility_to1.12422559
80MP0003724_increased_susceptibility_to1.11896070
81MP0005025_abnormal_response_to1.11083481
82MP0010307_abnormal_tumor_latency1.10573017
83MP0002132_abnormal_respiratory_system1.09487931
84MP0003786_premature_aging1.08533176
85MP0002006_tumorigenesis1.07998816
86MP0003172_abnormal_lysosome_physiology1.05753046
87MP0000858_altered_metastatic_potential1.04490023
88MP0001697_abnormal_embryo_size1.01036270
89MP0001533_abnormal_skeleton_physiology1.00859566
90MP0001915_intracranial_hemorrhage1.00189706
91MP0002136_abnormal_kidney_physiology0.99098806
92MP0005636_abnormal_mineral_homeostasis0.98828420
93MP0005332_abnormal_amino_acid0.97918983
94MP0001845_abnormal_inflammatory_respons0.96842987
95MP0004233_abnormal_muscle_weight0.96326080
96* MP0003984_embryonic_growth_retardation0.93976293
97MP0002085_abnormal_embryonic_tissue0.93552705
98MP0001663_abnormal_digestive_system0.92909536
99MP0003943_abnormal_hepatobiliary_system0.90462459
100MP0002933_joint_inflammation0.89738841
101MP0002009_preneoplasia0.89370269
102* MP0000477_abnormal_intestine_morphology0.88873455
103* MP0002088_abnormal_embryonic_growth/wei0.88651062
104* MP0005380_embryogenesis_phenotype0.88571702
105* MP0001672_abnormal_embryogenesis/_devel0.88571702
106MP0009053_abnormal_anal_canal0.88109681
107MP0005387_immune_system_phenotype0.86371289
108MP0001790_abnormal_immune_system0.86371289
109MP0008469_abnormal_protein_level0.85835199
110* MP0000598_abnormal_liver_morphology0.85660986
111MP0003123_paternal_imprinting0.85369190
112MP0005083_abnormal_biliary_tract0.84487304
113MP0000566_synostosis0.84311846
114MP0005666_abnormal_adipose_tissue0.83968288
115MP0003938_abnormal_ear_development0.83648717
116MP0004947_skin_inflammation0.82150775
117MP0009379_abnormal_foot_pigmentation0.81458787
118MP0000358_abnormal_cell_content/0.81083415
119MP0001346_abnormal_lacrimal_gland0.80608155
120MP0002086_abnormal_extraembryonic_tissu0.78828445
121MP0005058_abnormal_lysosome_morphology0.76772978
122MP0004019_abnormal_vitamin_homeostasis0.74287851
123MP0004197_abnormal_fetal_growth/weight/0.73333845
124MP0001293_anophthalmia0.72753743
125MP0001958_emphysema0.70701016
126MP0003011_delayed_dark_adaptation0.69778743
127MP0009278_abnormal_bone_marrow0.69640698
128MP0009672_abnormal_birth_weight0.68127186
129MP0002419_abnormal_innate_immunity0.67445521
130MP0004043_abnormal_pH_regulation0.66345931
131MP0008961_abnormal_basal_metabolism0.65949898
132MP0005319_abnormal_enzyme/_coenzyme0.64912446
133MP0005220_abnormal_exocrine_pancreas0.63717036

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)5.60134574
2Abnormality of cells of the erythroid lineage (HP:0012130)5.47656471
3Reticulocytopenia (HP:0001896)4.98891761
4Recurrent abscess formation (HP:0002722)4.43176047
5Thrombocytosis (HP:0001894)4.40981555
6Eczematoid dermatitis (HP:0000976)4.28583437
7Aplastic anemia (HP:0001915)3.93207858
8Abnormality of the heme biosynthetic pathway (HP:0010472)3.88387525
9Recurrent bacterial skin infections (HP:0005406)3.82548842
10Obstructive lung disease (HP:0006536)3.76390777
11Chronic obstructive pulmonary disease (HP:0006510)3.76390777
12Recurrent gram-negative bacterial infections (HP:0005420)3.58116728
13IgM deficiency (HP:0002850)3.48864726
14Hypochromic microcytic anemia (HP:0004840)3.46087600
15Hypochromic anemia (HP:0001931)3.30018088
16Macrocytic anemia (HP:0001972)3.26100633
17Myositis (HP:0100614)3.22648326
18Oral leukoplakia (HP:0002745)3.22533443
19Birth length less than 3rd percentile (HP:0003561)3.07174377
20Abnormality of macrophages (HP:0004311)3.03778194
21Pallor (HP:0000980)3.03448982
22Broad distal phalanx of finger (HP:0009836)3.01879601
23Orchitis (HP:0100796)2.92177674
24Cellulitis (HP:0100658)2.72667788
25Gastrointestinal infarctions (HP:0005244)2.71233799
26Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.69298513
27Microvesicular hepatic steatosis (HP:0001414)2.67793004
28Mediastinal lymphadenopathy (HP:0100721)2.66510847
29Petechiae (HP:0000967)2.62882515
30Pancytopenia (HP:0001876)2.61681989
31Increased IgE level (HP:0003212)2.57592219
32Recurrent fungal infections (HP:0002841)2.56063887
33Abnormality of reticulocytes (HP:0004312)2.54836064
34Rough bone trabeculation (HP:0100670)2.49812822
35Multiple enchondromatosis (HP:0005701)2.49384781
36Meningitis (HP:0001287)2.42373849
37Deep venous thrombosis (HP:0002625)2.40496711
38Amaurosis fugax (HP:0100576)2.37512465
39Elevated erythrocyte sedimentation rate (HP:0003565)2.36686029
40Aplasia/Hypoplasia of the sacrum (HP:0008517)2.36634194
41Hepatosplenomegaly (HP:0001433)2.36190762
42Hypertensive crisis (HP:0100735)2.34429243
43Decreased activity of mitochondrial respiratory chain (HP:0008972)2.32790274
44Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.32790274
45Selective tooth agenesis (HP:0001592)2.32541952
46Recurrent skin infections (HP:0001581)2.31468137
47Premature ovarian failure (HP:0008209)2.30236126
48Chronic otitis media (HP:0000389)2.30124009
4911 pairs of ribs (HP:0000878)2.28853100
50Optic neuritis (HP:0100653)2.27712924
51Retrobulbar optic neuritis (HP:0100654)2.27712924
52Encephalitis (HP:0002383)2.26467608
53Microretrognathia (HP:0000308)2.25412478
54Abnormal gallbladder physiology (HP:0012438)2.24893164
55Cholecystitis (HP:0001082)2.24893164
56Megaloblastic anemia (HP:0001889)2.24742602
57Progressive muscle weakness (HP:0003323)2.23142924
58Stomatitis (HP:0010280)2.22755906
59Premature skin wrinkling (HP:0100678)2.22026063
60Abnormality of pyrimidine metabolism (HP:0004353)2.21511187
61Urticaria (HP:0001025)2.20848634
62Myelodysplasia (HP:0002863)2.20481241
63Abnormality of T cell physiology (HP:0011840)2.19426314
64Ulnar bowing (HP:0003031)2.18355441
65Agnosia (HP:0010524)2.17577187
66Abnormal delayed hypersensitivity skin test (HP:0002963)2.17162097
67Seborrheic dermatitis (HP:0001051)2.15751043
68Hemorrhage of the eye (HP:0011885)2.13185331
69Anorexia (HP:0002039)2.13100036
70Abnormality of T cells (HP:0002843)2.12899289
71Colon cancer (HP:0003003)2.12171705
72Metaphyseal dysplasia (HP:0100255)2.11828404
73Partial duplication of thumb phalanx (HP:0009944)2.11308586
74Severe visual impairment (HP:0001141)2.10761403
75Abnormal platelet function (HP:0011869)2.09533209
76Impaired platelet aggregation (HP:0003540)2.09533209
77Abnormality of the fingertips (HP:0001211)2.05933845
78Aplasia/Hypoplasia of the thymus (HP:0010515)2.05889872
79Partial duplication of the phalanx of hand (HP:0009999)2.05666918
80Disproportionate tall stature (HP:0001519)2.04486444
81Increased serum lactate (HP:0002151)2.03768948
82Increased density of long bones (HP:0006392)2.02601364
83Poikiloderma (HP:0001029)2.02137304
84Prolonged bleeding time (HP:0003010)2.01786645
85Trismus (HP:0000211)2.01485635
86Self-mutilation (HP:0000742)1.98850394
87Micronodular cirrhosis (HP:0001413)1.98288883
88Glossoptosis (HP:0000162)1.98077960
89Testicular atrophy (HP:0000029)1.97944477
90Gastrointestinal inflammation (HP:0004386)1.96843353
91Reticulocytosis (HP:0001923)1.95708721
92Reduced antithrombin III activity (HP:0001976)1.94839959
93Abnormal number of incisors (HP:0011064)1.94284916
94Type I transferrin isoform profile (HP:0003642)1.94183851
95Lymphoma (HP:0002665)1.94080423
96Viral hepatitis (HP:0006562)1.93690474
97Proximal tubulopathy (HP:0000114)1.93257754
98Ragged-red muscle fibers (HP:0003200)1.92843982
99Abnormal vertebral ossification (HP:0100569)1.92269028
100Gingivitis (HP:0000230)1.91221674
101Nonimmune hydrops fetalis (HP:0001790)1.89246958
102Abnormality of the distal phalanx of the thumb (HP:0009617)1.86766970
103Abnormality of the prostate (HP:0008775)1.85841735
104Microcytic anemia (HP:0001935)1.85116897
105Abnormality of alkaline phosphatase activity (HP:0004379)1.84971412
106Carpal bone hypoplasia (HP:0001498)1.84916767
107Abnormal protein glycosylation (HP:0012346)1.84562830
108Abnormal glycosylation (HP:0012345)1.84562830
109Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.84562830
110Abnormal protein N-linked glycosylation (HP:0012347)1.84562830
111Intestinal fistula (HP:0100819)1.84125444
112Abnormal enzyme/coenzyme activity (HP:0012379)1.83139465
113Chromosomal breakage induced by crosslinking agents (HP:0003221)1.82767409
114Basal cell carcinoma (HP:0002671)1.82341434
115Vaginal fistula (HP:0004320)1.82167567
116T lymphocytopenia (HP:0005403)1.81715807
117Abnormality of the anterior horn cell (HP:0006802)1.81622259
118Degeneration of anterior horn cells (HP:0002398)1.81622259
119Entropion (HP:0000621)1.81520247
120Recurrent viral infections (HP:0004429)1.80292072
121Premature graying of hair (HP:0002216)1.80255494
122Polyuria (HP:0000103)1.79934693
123Nausea (HP:0002018)1.79932893
124Chromsome breakage (HP:0040012)1.79263031
125Polycythemia (HP:0001901)1.78209674
126Osteomalacia (HP:0002749)1.77650923
127Hypertriglyceridemia (HP:0002155)1.77115520
128Truncus arteriosus (HP:0001660)1.76921486
129Segmental peripheral demyelination/remyelination (HP:0003481)1.76880801
130Irregular epiphyses (HP:0010582)1.76675620
131Abnormal trabecular bone morphology (HP:0100671)1.76599814
132IgA deficiency (HP:0002720)1.75485760
133Abnormal platelet volume (HP:0011876)1.74954156
134Combined immunodeficiency (HP:0005387)1.74816620
135Abnormality of the columella (HP:0009929)1.74750201
136Subacute progressive viral hepatitis (HP:0006572)1.73492452
137Hepatocellular necrosis (HP:0001404)1.73341020
138IgG deficiency (HP:0004315)1.73159660
139Metaphyseal cupping (HP:0003021)1.73133244
140Muscle fiber atrophy (HP:0100295)1.73062808
141Hepatic necrosis (HP:0002605)1.72258972
142Abnormality of chromosome stability (HP:0003220)1.71049855
143Hyperglycinuria (HP:0003108)1.70861879
144Gout (HP:0001997)1.70574778
145Abnormality of cochlea (HP:0000375)1.70184033
146Severe combined immunodeficiency (HP:0004430)1.69840131
147Abnormality of the phalanges of the hallux (HP:0010057)1.69456873
148Lymphopenia (HP:0001888)1.68890976
149Duplication of thumb phalanx (HP:0009942)1.68542245
150Fatigue (HP:0012378)1.68476951
151Cerebral hypomyelination (HP:0006808)1.68442597
152Cellular immunodeficiency (HP:0005374)1.68222536
153Abnormality of the thymus (HP:0000777)1.67584807
154Keratoconjunctivitis sicca (HP:0001097)1.67520123
155Abnormality of cells of the lymphoid lineage (HP:0012140)1.66995432
156Panhypogammaglobulinemia (HP:0003139)1.66978946
157Bone marrow hypocellularity (HP:0005528)1.66737136
158Cleft eyelid (HP:0000625)1.66734838
159Recurrent cutaneous fungal infections (HP:0011370)1.66230060
160Chronic mucocutaneous candidiasis (HP:0002728)1.66230060
161Generalized aminoaciduria (HP:0002909)1.65682892
162Pulmonary fibrosis (HP:0002206)1.65065555
163Abnormality of magnesium homeostasis (HP:0004921)1.64852451
164Epistaxis (HP:0000421)1.63808279
165Acute myeloid leukemia (HP:0004808)1.62130274
166Posterior subcapsular cataract (HP:0007787)1.62022768
167Exertional dyspnea (HP:0002875)1.59905328
168Increased serum ferritin (HP:0003281)1.59702834
169Abnormality of the thoracic spine (HP:0100711)1.58944961
170Abnormality of T cell number (HP:0011839)1.58524136
171Autoimmune thrombocytopenia (HP:0001973)1.57419724
172Abnormal urine output (HP:0012590)1.57212631
173Absent thumb (HP:0009777)1.57193740
174Respiratory difficulties (HP:0002880)1.56556430
175Overlapping toe (HP:0001845)1.55404620
176Squamous cell carcinoma (HP:0002860)1.55401682

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.23771965
2NME23.41071441
3MAP4K13.11150256
4EEF2K3.07911397
5IRAK43.01927562
6CDC72.93949991
7RIPK42.82486634
8EIF2AK12.72103834
9VRK22.67173668
10BUB12.59820439
11WEE12.44926603
12ACVR1B2.41808109
13SCYL22.39897550
14PIM22.28731707
15TSSK62.15629646
16TNK22.08129630
17RPS6KA42.05679194
18SIK12.03727674
19MAP2K31.94905979
20TGFBR11.82832544
21JAK31.82035435
22PRPF4B1.80231722
23IRAK21.75386085
24PASK1.73722334
25ZAP701.70949374
26TEC1.64153944
27BCKDK1.63753945
28STK161.59921362
29EIF2AK31.58434166
30STK101.58182906
31BRSK21.57321979
32LRRK21.56559936
33NEK21.54954277
34PKN21.52559098
35MAP3K101.50914032
36VRK11.50382883
37FLT31.49637879
38TRIB31.46094772
39NEK11.43308117
40SRPK11.42584260
41PTK61.41545431
42KDR1.41170995
43ICK1.36724276
44RPS6KB21.35916072
45MAP3K81.34956222
46KIT1.34562956
47BTK1.33210768
48TESK21.32529154
49CDK71.32235700
50MAP3K111.30717608
51ATR1.29856480
52EPHB11.26684562
53CAMK1D1.25646166
54TXK1.23341357
55FES1.21049169
56MKNK11.19650306
57DYRK31.16798432
58PIM11.16372783
59CSK1.16264343
60MAP3K31.11304623
61AURKB1.11026028
62CDK41.09121126
63TAOK11.08565339
64NME11.04812631
65PRKD21.04667661
66MARK21.03187918
67GRK61.02935594
68MAP3K10.99782909
69CSF1R0.97908624
70FGFR40.95126493
71TAF10.94313727
72TTK0.93341341
73BRSK10.93260458
74TAOK20.92908335
75PLK10.90918305
76BLK0.85917462
77PAK40.82936078
78HCK0.79801798
79KSR20.79677935
80TBK10.78329541
81CDK120.78039054
82TLK10.77271224
83ERN10.76231805
84IKBKB0.75580124
85ITK0.73257731
86CCNB10.73219189
87CHEK10.73057025
88SYK0.69273144
89MAP2K40.68963090
90PAK20.67974058
91CHUK0.67234451
92IRAK10.66156235
93PDPK10.64693148
94RPS6KL10.63919270
95RPS6KC10.63919270
96FGR0.63762397
97WNK30.62936526
98MAP3K60.62758139
99SIK30.62572396
100AURKA0.61681641
101CAMK1G0.60698525
102STK40.60197346
103CDK80.59660303
104MAPKAPK30.57810406
105TYK20.57055183
106LCK0.55492436
107CSNK2A20.55338865
108MST40.54919801
109LYN0.54221242
110RAF10.52127208
111YES10.50667711
112CDK20.50191102
113ALK0.49680226
114MTOR0.48596812
115IKBKE0.48567444
116ATM0.46959024
117IRAK30.45525253
118MAPK40.44797494
119FGFR20.44630947
120MAPK110.44618203
121CSNK2A10.43643552
122RPS6KA10.43510540
123CHEK20.43442475
124RPS6KB10.43191195
125PLK30.42519521
126CLK10.41654738
127MARK30.40681671
128MAP2K20.39820990
129CDK190.39274255
130AKT20.38642064
131PLK40.37984325
132MAPKAPK20.37763700
133DAPK10.37561644
134PAK10.37007802
135ILK0.36788910
136MKNK20.36413966
137JAK20.36165762
138TIE10.35707335
139STK110.35458442
140PRKD30.35165661
141RPS6KA60.34923483
142MATK0.34601182
143PDK10.33244965
144MAP3K70.32436066
145BMX0.32080572

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.85202079
2Ribosome_Homo sapiens_hsa030103.70164511
3Mismatch repair_Homo sapiens_hsa034303.42390597
4One carbon pool by folate_Homo sapiens_hsa006703.31658010
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.25646495
6Cyanoamino acid metabolism_Homo sapiens_hsa004603.06306886
7Base excision repair_Homo sapiens_hsa034103.06062899
8Spliceosome_Homo sapiens_hsa030402.74656141
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.72912446
10RNA polymerase_Homo sapiens_hsa030202.64600781
11Proteasome_Homo sapiens_hsa030502.45091341
12Pyrimidine metabolism_Homo sapiens_hsa002402.40382389
13RNA transport_Homo sapiens_hsa030132.35993130
14Nucleotide excision repair_Homo sapiens_hsa034202.21717425
15Homologous recombination_Homo sapiens_hsa034401.94595288
16Cell cycle_Homo sapiens_hsa041101.76764533
17Notch signaling pathway_Homo sapiens_hsa043301.64650398
18Non-small cell lung cancer_Homo sapiens_hsa052231.60081874
19RNA degradation_Homo sapiens_hsa030181.52311185
20Sulfur relay system_Homo sapiens_hsa041221.47634299
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46176971
22Pentose phosphate pathway_Homo sapiens_hsa000301.45660391
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.45177311
24Osteoclast differentiation_Homo sapiens_hsa043801.44361891
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42519857
26Biosynthesis of amino acids_Homo sapiens_hsa012301.41977153
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.39956191
28Non-homologous end-joining_Homo sapiens_hsa034501.37287891
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35406792
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.32868994
31Selenocompound metabolism_Homo sapiens_hsa004501.30996329
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.26965725
33Purine metabolism_Homo sapiens_hsa002301.23294631
34Primary immunodeficiency_Homo sapiens_hsa053401.19231678
35Fanconi anemia pathway_Homo sapiens_hsa034601.19191147
36Carbon metabolism_Homo sapiens_hsa012001.15961969
37Folate biosynthesis_Homo sapiens_hsa007901.15610387
38Pancreatic cancer_Homo sapiens_hsa052121.15371915
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.06741876
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03931036
41N-Glycan biosynthesis_Homo sapiens_hsa005101.03589582
42p53 signaling pathway_Homo sapiens_hsa041151.03091977
43Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.00004869
44Herpes simplex infection_Homo sapiens_hsa051680.97303097
45Colorectal cancer_Homo sapiens_hsa052100.94170823
46Legionellosis_Homo sapiens_hsa051340.93951462
47mRNA surveillance pathway_Homo sapiens_hsa030150.91082150
48Bladder cancer_Homo sapiens_hsa052190.91000614
49Epstein-Barr virus infection_Homo sapiens_hsa051690.88009065
50Antigen processing and presentation_Homo sapiens_hsa046120.87876932
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87733580
52Staphylococcus aureus infection_Homo sapiens_hsa051500.86831672
53Toll-like receptor signaling pathway_Homo sapiens_hsa046200.85646097
54Glutathione metabolism_Homo sapiens_hsa004800.85013345
55Measles_Homo sapiens_hsa051620.82645789
56Endometrial cancer_Homo sapiens_hsa052130.81542774
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78503759
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75460157
59Viral carcinogenesis_Homo sapiens_hsa052030.72815384
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72488880
61Tuberculosis_Homo sapiens_hsa051520.72435876
62Prostate cancer_Homo sapiens_hsa052150.71753499
63Renin-angiotensin system_Homo sapiens_hsa046140.70758584
64Hepatitis C_Homo sapiens_hsa051600.68831886
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.68665705
66Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67947665
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65914256
68Pyruvate metabolism_Homo sapiens_hsa006200.65336303
69Protein export_Homo sapiens_hsa030600.64797851
70VEGF signaling pathway_Homo sapiens_hsa043700.64629063
71Basal transcription factors_Homo sapiens_hsa030220.63280186
72Hematopoietic cell lineage_Homo sapiens_hsa046400.63152050
73HTLV-I infection_Homo sapiens_hsa051660.62202090
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61274496
75African trypanosomiasis_Homo sapiens_hsa051430.60506284
76Renal cell carcinoma_Homo sapiens_hsa052110.60390964
77Thyroid cancer_Homo sapiens_hsa052160.60187011
78Apoptosis_Homo sapiens_hsa042100.60071705
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59538175
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59459953
81Fructose and mannose metabolism_Homo sapiens_hsa000510.59088977
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.58711690
83Systemic lupus erythematosus_Homo sapiens_hsa053220.57470758
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56621805
85Leishmaniasis_Homo sapiens_hsa051400.55843168
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55745887
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54970097
88Shigellosis_Homo sapiens_hsa051310.54378764
89Fatty acid biosynthesis_Homo sapiens_hsa000610.53583125
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53500861
91Malaria_Homo sapiens_hsa051440.53348558
92Propanoate metabolism_Homo sapiens_hsa006400.53274855
93Acute myeloid leukemia_Homo sapiens_hsa052210.51777126
94Chemokine signaling pathway_Homo sapiens_hsa040620.51735576
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49508798
96Galactose metabolism_Homo sapiens_hsa000520.48580186
97Basal cell carcinoma_Homo sapiens_hsa052170.46846392
98Huntingtons disease_Homo sapiens_hsa050160.46029395
99Hepatitis B_Homo sapiens_hsa051610.45368709
100Small cell lung cancer_Homo sapiens_hsa052220.44435714
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.43478513
102Intestinal immune network for IgA production_Homo sapiens_hsa046720.43324329
103* Vitamin digestion and absorption_Homo sapiens_hsa049770.41962474
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41283086
105Arginine and proline metabolism_Homo sapiens_hsa003300.39199905
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38708913
107T cell receptor signaling pathway_Homo sapiens_hsa046600.38633677
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38414640
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.37162828
110Influenza A_Homo sapiens_hsa051640.36991773
111Insulin signaling pathway_Homo sapiens_hsa049100.36895755
112Allograft rejection_Homo sapiens_hsa053300.36116293
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35744957
114Chronic myeloid leukemia_Homo sapiens_hsa052200.34727603
115Metabolic pathways_Homo sapiens_hsa011000.33232110
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33185787
117Lysine degradation_Homo sapiens_hsa003100.32883852
118HIF-1 signaling pathway_Homo sapiens_hsa040660.32314279
119Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.32223662
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31919284
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.31912777
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28630196
123Protein digestion and absorption_Homo sapiens_hsa049740.28344183
124Peroxisome_Homo sapiens_hsa041460.28295464
125Other glycan degradation_Homo sapiens_hsa005110.28092566
126B cell receptor signaling pathway_Homo sapiens_hsa046620.27941189
127Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27039652
128Viral myocarditis_Homo sapiens_hsa054160.25361385
129Fatty acid degradation_Homo sapiens_hsa000710.24027076
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22829073
131Type I diabetes mellitus_Homo sapiens_hsa049400.22634203
132Parkinsons disease_Homo sapiens_hsa050120.22622023

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