SLC19A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the thiamin transporter protein. Mutations in this gene cause thiamin-responsive megaloblastic anemia syndrome (TRMA), which is an autosomal recessive disorder characterized by diabetes mellitus, megaloblastic anemia and sensorineural deafness. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.42609208
2L-phenylalanine catabolic process (GO:0006559)7.42609208
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.22972851
4L-phenylalanine metabolic process (GO:0006558)7.22972851
5aromatic amino acid family catabolic process (GO:0009074)6.66708336
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.22110541
7kynurenine metabolic process (GO:0070189)6.04334342
8tryptophan catabolic process (GO:0006569)6.02150047
9indole-containing compound catabolic process (GO:0042436)6.02150047
10indolalkylamine catabolic process (GO:0046218)6.02150047
11bile acid biosynthetic process (GO:0006699)5.87366560
12negative regulation of fibrinolysis (GO:0051918)5.85591801
13glyoxylate metabolic process (GO:0046487)5.70681324
14urea cycle (GO:0000050)5.68657633
15urea metabolic process (GO:0019627)5.68657633
16tryptophan metabolic process (GO:0006568)5.64688285
17cysteine metabolic process (GO:0006534)5.61227009
18regulation of fibrinolysis (GO:0051917)5.53466118
19high-density lipoprotein particle remodeling (GO:0034375)5.52587366
20alpha-linolenic acid metabolic process (GO:0036109)5.51569504
21peptidyl-glutamic acid carboxylation (GO:0017187)5.45631151
22protein carboxylation (GO:0018214)5.45631151
23sulfur amino acid catabolic process (GO:0000098)5.44920371
24regulation of protein activation cascade (GO:2000257)5.41006549
25serine family amino acid catabolic process (GO:0009071)5.37557359
26complement activation, alternative pathway (GO:0006957)5.34938617
27nitrogen cycle metabolic process (GO:0071941)5.20378689
28glycine metabolic process (GO:0006544)5.06212484
29regulation of complement activation (GO:0030449)5.06078626
30bile acid metabolic process (GO:0008206)5.02341569
31homocysteine metabolic process (GO:0050667)4.95796437
32aromatic amino acid family metabolic process (GO:0009072)4.87741898
33reverse cholesterol transport (GO:0043691)4.79926629
34regulation of cholesterol esterification (GO:0010872)4.76256995
35protein-lipid complex remodeling (GO:0034368)4.67624974
36macromolecular complex remodeling (GO:0034367)4.67624974
37plasma lipoprotein particle remodeling (GO:0034369)4.67624974
38regulation of triglyceride catabolic process (GO:0010896)4.67265106
39alpha-amino acid catabolic process (GO:1901606)4.67188154
40lysine catabolic process (GO:0006554)4.66270264
41lysine metabolic process (GO:0006553)4.66270264
42tyrosine metabolic process (GO:0006570)4.65926831
43negative regulation of cholesterol transport (GO:0032375)4.64681532
44negative regulation of sterol transport (GO:0032372)4.64681532
45fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.63703463
46amino-acid betaine metabolic process (GO:0006577)4.62492102
47serine family amino acid metabolic process (GO:0009069)4.60718439
48triglyceride homeostasis (GO:0070328)4.58017663
49acylglycerol homeostasis (GO:0055090)4.58017663
50imidazole-containing compound metabolic process (GO:0052803)4.57435650
51serine family amino acid biosynthetic process (GO:0009070)4.54661341
52phospholipid efflux (GO:0033700)4.41986273
53plasma lipoprotein particle clearance (GO:0034381)4.40125167
54response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.38265997
55bile acid and bile salt transport (GO:0015721)4.36876663
56coenzyme catabolic process (GO:0009109)4.35396857
57glutamate metabolic process (GO:0006536)4.32520375
58cellular amino acid catabolic process (GO:0009063)4.28437479
59dicarboxylic acid biosynthetic process (GO:0043650)4.22554087
60indolalkylamine metabolic process (GO:0006586)4.19081779
61cellular modified amino acid catabolic process (GO:0042219)4.18597017
62actin-myosin filament sliding (GO:0033275)4.16755990
63muscle filament sliding (GO:0030049)4.16755990
64cellular glucuronidation (GO:0052695)4.13574873
65ethanol oxidation (GO:0006069)4.12040580
66cholesterol efflux (GO:0033344)4.11594215
67fibrinolysis (GO:0042730)4.09611000
68cellular ketone body metabolic process (GO:0046950)4.08828356
69cellular biogenic amine catabolic process (GO:0042402)4.07897219
70amine catabolic process (GO:0009310)4.07897219
71benzene-containing compound metabolic process (GO:0042537)4.01058559
72nuclear pore complex assembly (GO:0051292)3.98892026
73plasma lipoprotein particle assembly (GO:0034377)3.98763671
74regulation of cholesterol homeostasis (GO:2000188)3.93004299
75aldehyde catabolic process (GO:0046185)3.92301222
76arginine metabolic process (GO:0006525)3.87647507
77low-density lipoprotein particle remodeling (GO:0034374)3.87542028
78sarcoplasmic reticulum calcium ion transport (GO:0070296)3.83995576
79very-low-density lipoprotein particle assembly (GO:0034379)3.82071322
80response to muscle activity (GO:0014850)3.80248385
81drug catabolic process (GO:0042737)3.76478184
82cholesterol homeostasis (GO:0042632)3.76348199
83blood coagulation, intrinsic pathway (GO:0007597)3.75511304
84nuclear pore organization (GO:0006999)3.75440768
85skeletal muscle contraction (GO:0003009)3.74664361
86cofactor catabolic process (GO:0051187)3.73324455
87complement activation, classical pathway (GO:0006958)3.72975979
88sterol homeostasis (GO:0055092)3.71310966
89complement activation (GO:0006956)3.69397668
90regulation of bile acid biosynthetic process (GO:0070857)3.68694073
91acetyl-CoA metabolic process (GO:0006084)3.68596342
92organic acid catabolic process (GO:0016054)3.67127717
93carboxylic acid catabolic process (GO:0046395)3.67127717
94phospholipid homeostasis (GO:0055091)3.67105008
95negative regulation of fatty acid biosynthetic process (GO:0045717)3.66326764
96protein activation cascade (GO:0072376)3.64777575
97positive regulation of lipid catabolic process (GO:0050996)3.63211237
98cytolysis (GO:0019835)3.62408280
99response to nitrosative stress (GO:0051409)3.61638900
100protein-lipid complex assembly (GO:0065005)3.59856056
101intestinal cholesterol absorption (GO:0030299)3.59391619
102uronic acid metabolic process (GO:0006063)3.58884306
103glucuronate metabolic process (GO:0019585)3.58884306
104actin-mediated cell contraction (GO:0070252)3.58677723
105positive regulation of triglyceride lipase activity (GO:0061365)3.58517102
106positive regulation of lipoprotein lipase activity (GO:0051006)3.58517102
107L-serine metabolic process (GO:0006563)3.57865998
108heme transport (GO:0015886)3.56327463
109lipoprotein metabolic process (GO:0042157)3.55371534
110paraxial mesoderm development (GO:0048339)3.43773474
111carnitine shuttle (GO:0006853)3.39357361
112regulation of centriole replication (GO:0046599)3.28806555
113intestinal epithelial cell development (GO:0060576)3.15586847
114IMP metabolic process (GO:0046040)3.12930397
115sarcomere organization (GO:0045214)3.10101287
116mitotic sister chromatid cohesion (GO:0007064)3.07788078
117carnitine transmembrane transport (GO:1902603)3.07668420
118protein complex localization (GO:0031503)3.06708285
119cellular protein complex localization (GO:0034629)3.06327762
120mitotic metaphase plate congression (GO:0007080)3.04443793
121metaphase plate congression (GO:0051310)3.01229843
122glycogen catabolic process (GO:0005980)3.00269344
123mitotic chromosome condensation (GO:0007076)2.95926113
124biotin metabolic process (GO:0006768)2.93399075
125amino-acid betaine transport (GO:0015838)2.88500103
126carnitine transport (GO:0015879)2.88500103
127fatty acid transmembrane transport (GO:1902001)2.78861467
128striated muscle contraction (GO:0006941)2.78563357
129myofibril assembly (GO:0030239)2.73064367
130regulation of relaxation of muscle (GO:1901077)2.72415749
131creatine metabolic process (GO:0006600)2.71494941
132protein localization to kinetochore (GO:0034501)2.68120863
133pore complex assembly (GO:0046931)2.67189027
134glucan catabolic process (GO:0009251)2.66107004
135skeletal muscle adaptation (GO:0043501)2.65901094
136IMP biosynthetic process (GO:0006188)2.65565073
137regulation of RNA export from nucleus (GO:0046831)2.65350783
138gluconeogenesis (GO:0006094)2.64411229
139ribosome assembly (GO:0042255)2.63767343
140muscle cell cellular homeostasis (GO:0046716)2.60423281
141actin filament-based movement (GO:0030048)2.59831123
142negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.59597047
143L-alpha-amino acid transmembrane transport (GO:1902475)2.58160470
144glycogen biosynthetic process (GO:0005978)2.58105830
145glucan biosynthetic process (GO:0009250)2.58105830
146NADH metabolic process (GO:0006734)2.57987142
147fructose metabolic process (GO:0006000)2.54177060
148regulation of skeletal muscle contraction (GO:0014819)2.54120588
149cellular polysaccharide catabolic process (GO:0044247)2.53769239
150hexose biosynthetic process (GO:0019319)2.53376559
151actomyosin structure organization (GO:0031032)2.51887088
152intracellular lipid transport (GO:0032365)2.51626993
153nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.46961275
154protein localization to chromosome, centromeric region (GO:0071459)2.46628548
155peptidyl-lysine dimethylation (GO:0018027)2.46301550
156cardiac myofibril assembly (GO:0055003)2.46175699
157regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.45245303
158low-density lipoprotein particle clearance (GO:0034383)2.39117894
159quaternary ammonium group transport (GO:0015697)2.38629899
160establishment of chromosome localization (GO:0051303)2.36682335
161oxaloacetate metabolic process (GO:0006107)2.34952709
162kinetochore organization (GO:0051383)2.32883582
163aspartate family amino acid catabolic process (GO:0009068)2.31418925
164negative regulation of potassium ion transmembrane transport (GO:1901380)2.30091583
165tricarboxylic acid cycle (GO:0006099)2.29461037
166positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.28488130
167positive regulation of chromosome segregation (GO:0051984)2.28314932
168COPII vesicle coating (GO:0048208)2.27928140
169positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.26657882
170positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.26657882
171positive regulation of mitotic sister chromatid separation (GO:1901970)2.26657882
172positive regulation of hormone metabolic process (GO:0032352)2.26164158
173polysaccharide catabolic process (GO:0000272)2.24751974
174mitotic G2/M transition checkpoint (GO:0044818)2.23824761
175monosaccharide biosynthetic process (GO:0046364)2.23388245
176prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.23221759
177fatty acid homeostasis (GO:0055089)2.22037806
178cardiac muscle cell development (GO:0055013)2.21985382
179kinetochore assembly (GO:0051382)2.21402344
180regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.21196250
181muscle atrophy (GO:0014889)2.19786781
182positive regulation of catenin import into nucleus (GO:0035413)2.19567032
183regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.19423816
184nucleotide-sugar biosynthetic process (GO:0009226)2.18905065
185regulation of centrosome cycle (GO:0046605)2.18575918
186desmosome organization (GO:0002934)2.16622427
187UDP-N-acetylglucosamine metabolic process (GO:0006047)2.16195879
188glycogen metabolic process (GO:0005977)2.15447426
189gap junction assembly (GO:0016264)2.13015142
190response to inactivity (GO:0014854)2.11642631
191CENP-A containing nucleosome assembly (GO:0034080)2.11455740
192cardiac muscle contraction (GO:0060048)2.11335195
193positive regulation of hormone biosynthetic process (GO:0046886)2.10937677
194DNA unwinding involved in DNA replication (GO:0006268)2.10857971
195adult heart development (GO:0007512)2.09270568

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.98847249
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.98244488
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.54094427
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.14508355
5E2F7_22180533_ChIP-Seq_HELA_Human6.08509266
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.94646721
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.81392213
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.50795707
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.94595676
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.77674657
11ESR1_20079471_ChIP-ChIP_T-47D_Human3.51288402
12FOXM1_23109430_ChIP-Seq_U2OS_Human3.40492546
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.85387335
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.80800941
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.63869400
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.39450453
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.32391698
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.13091350
19PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.05884734
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.04572486
21* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03247551
22ZNF217_24962896_ChIP-Seq_MCF-7_Human2.01354501
23* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.5157470
24TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.99414033
25ESR1_15608294_ChIP-ChIP_MCF-7_Human1.98083938
26CLOCK_20551151_ChIP-Seq_293T_Human1.89251785
27PADI4_21655091_ChIP-ChIP_MCF-7_Human1.85872760
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.66711727
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66457821
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62900924
31* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.61591850
32ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61360164
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.58830530
34* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.49399610
35STAT3_1855785_ChIP-Seq_MESCs_Mouse1.48571972
36ZNF263_19887448_ChIP-Seq_K562_Human1.46915073
37FOXA2_19822575_ChIP-Seq_HepG2_Human1.42993610
38WT1_19549856_ChIP-ChIP_CCG9911_Human1.42785081
39SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.40700463
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40389418
41* HNF4A_19822575_ChIP-Seq_HepG2_Human1.37504332
42TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33568815
43* CHD1_26751641_Chip-Seq_LNCaP_Human1.32077038
44EP300_21415370_ChIP-Seq_HL-1_Mouse1.30121385
45* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.29885756
46TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.28835008
47MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.27613337
48* GATA3_24758297_ChIP-Seq_MCF-7_Human1.27366912
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24032297
50RXRA_24833708_ChIP-Seq_LIVER_Mouse1.23411084
51* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18634548
52* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.18516963
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18119970
54AHR_22903824_ChIP-Seq_MCF-7_Human1.17740833
55HTT_18923047_ChIP-ChIP_STHdh_Human1.16823858
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16225790
57ELK1_19687146_ChIP-ChIP_HELA_Human1.13878499
58CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12222720
59SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11093036
60TP63_17297297_ChIP-ChIP_HaCaT_Human1.10754505
61GATA1_22025678_ChIP-Seq_K562_Human1.10153785
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.09623201
63RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09387610
64GATA4_21415370_ChIP-Seq_HL-1_Mouse1.09101710
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06460384
66* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.06121034
67ER_23166858_ChIP-Seq_MCF-7_Human1.05221648
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04384989
69* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.04357525
70NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.04242113
71PKCTHETA_26484144_Chip-Seq_BREAST_Human1.04082833
72NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.03622486
73TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02448351
74* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.01477911
75SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01161261
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.01020851
77SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00928269
78ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00678306
79ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00607410
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00539288
81SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99049769
82STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98712599
83TAF15_26573619_Chip-Seq_HEK293_Human0.96172040
84POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95866208
85EGR1_19374776_ChIP-ChIP_THP-1_Human0.94623200
86FUS_26573619_Chip-Seq_HEK293_Human0.88117760
87TFEB_21752829_ChIP-Seq_HELA_Human0.88026220
88AR_21909140_ChIP-Seq_LNCAP_Human0.87953108
89* TBX20_22328084_ChIP-Seq_HEART_Mouse0.86583715
90* TBX20_22080862_ChIP-Seq_HEART_Mouse0.86583715
91ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.86505832
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85705708
93NANOG_16153702_ChIP-ChIP_HESCs_Human0.85500639
94SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.85230181
95KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.84094856
96KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.84094856
97KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.84094856
98MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.83880766
99NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.83755230
100SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82813143
101RARA_24833708_ChIP-Seq_LIVER_Mouse0.81711122
102* GATA4_25053715_ChIP-Seq_YYC3_Human0.81015511
103THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.79225996
104ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.78471043
105NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.77874010
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.77869576
107* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.76285517
108TCF3_18692474_ChIP-Seq_MESCs_Mouse0.76248992
109EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.75129610
110SOX2_18692474_ChIP-Seq_MEFs_Mouse0.74844918
111E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.73094976
112SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.72199466
113* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.71191427
114POU5F1_16518401_ChIP-PET_MESCs_Mouse0.69593550
115OCT4_18692474_ChIP-Seq_MEFs_Mouse0.69061422
116RARB_24833708_ChIP-Seq_LIVER_Mouse0.68767314
117ESR2_21235772_ChIP-Seq_MCF-7_Human0.68242940
118PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.66196352
119* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.65930574
120PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.64620518
121* GATA6_25053715_ChIP-Seq_YYC3_Human0.64507122
122FOXO3_23340844_ChIP-Seq_DLD1_Human0.63293121
123NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.63044985
124FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.62058171
125NANOG_16518401_ChIP-PET_MESCs_Mouse0.61320795
126ATF3_27146783_Chip-Seq_COLON_Human0.61175201
127FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.60839146
128KAP1_22055183_ChIP-Seq_ESCs_Mouse0.60555884
129RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.60053313
130SOX2_18692474_ChIP-Seq_MESCs_Mouse0.56260567
131* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.55152981
132ESR1_21235772_ChIP-Seq_MCF-7_Human0.54111403
133GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.54090392
134CEBPB_22108803_ChIP-Seq_LS180_Human0.52902985
135* MYC_18555785_ChIP-Seq_MESCs_Mouse0.52442850
136TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.51397015
137NANOG_18692474_ChIP-Seq_MEFs_Mouse0.50502743
138LXR_22292898_ChIP-Seq_THP-1_Human0.48761849
139HIF1A_21447827_ChIP-Seq_MCF-7_Human0.48014781
140* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.47804879
141PPAR_26484153_Chip-Seq_NCI-H1993_Human0.47422918
142RACK7_27058665_Chip-Seq_MCF-7_Human0.47413514
143* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.47236808
144KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.46597870
145SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.45174542
146KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.45137122
147KLF4_18555785_ChIP-Seq_MESCs_Mouse0.44470153
148PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.44118509
149* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.43767836
150POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.43035940
151* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.42981675
152POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.42753666
153FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.42714412
154IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.41365776
155Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.40273436
156SOX17_20123909_ChIP-Seq_XEN_Mouse0.40140118
157NELFA_20434984_ChIP-Seq_ESCs_Mouse0.39913972
158NANOG_18555785_ChIP-Seq_MESCs_Mouse0.39435502

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.10356370
2MP0005360_urolithiasis7.39577658
3MP0005085_abnormal_gallbladder_physiolo6.37061704
4MP0005365_abnormal_bile_salt6.04074752
5MP0003806_abnormal_nucleotide_metabolis4.90315309
6MP0008875_abnormal_xenobiotic_pharmacok4.87721066
7MP0003252_abnormal_bile_duct3.87557844
8MP0003941_abnormal_skin_development3.49493076
9MP0010329_abnormal_lipoprotein_level3.48351726
10MP0009840_abnormal_foam_cell3.32158415
11MP0004233_abnormal_muscle_weight3.17446988
12MP0005083_abnormal_biliary_tract3.16211093
13MP0003646_muscle_fatigue2.97922589
14MP0000751_myopathy2.66005198
15MP0005332_abnormal_amino_acid2.63533341
16MP0001666_abnormal_nutrient_absorption2.56225779
17MP0003195_calcinosis2.53841585
18MP0000749_muscle_degeneration2.36617864
19MP0004084_abnormal_cardiac_muscle2.30462982
20MP0004036_abnormal_muscle_relaxation2.23046343
21MP0000609_abnormal_liver_physiology2.18861526
22MP0004145_abnormal_muscle_electrophysio2.17376974
23MP0003693_abnormal_embryo_hatching2.14285007
24MP0004019_abnormal_vitamin_homeostasis2.11466196
25MP0003191_abnormal_cellular_cholesterol2.10320901
26MP0003705_abnormal_hypodermis_morpholog2.06217057
27MP0004087_abnormal_muscle_fiber2.01740984
28MP0003950_abnormal_plasma_membrane2.01257548
29MP0002118_abnormal_lipid_homeostasis1.97105538
30MP0008057_abnormal_DNA_replication1.81058854
31MP0000747_muscle_weakness1.80272374
32MP0003868_abnormal_feces_composition1.79567872
33MP0005319_abnormal_enzyme/_coenzyme1.78550144
34MP0006138_congestive_heart_failure1.73754269
35MP0002106_abnormal_muscle_physiology1.72076788
36MP0009780_abnormal_chondrocyte_physiolo1.69140656
37MP0002138_abnormal_hepatobiliary_system1.68243885
38MP0003221_abnormal_cardiomyocyte_apopto1.67071017
39MP0000372_irregular_coat_pigmentation1.65022361
40MP0005076_abnormal_cell_differentiation1.59294162
41MP0000750_abnormal_muscle_regeneration1.56973253
42MP0004957_abnormal_blastocyst_morpholog1.53429526
43MP0001764_abnormal_homeostasis1.53085158
44MP0000759_abnormal_skeletal_muscle1.52797506
45MP0005369_muscle_phenotype1.49201558
46MP0005330_cardiomyopathy1.47791497
47MP0010094_abnormal_chromosome_stability1.47261052
48MP0010678_abnormal_skin_adnexa1.43850647
49MP0003111_abnormal_nucleus_morphology1.41928716
50MP0009697_abnormal_copulation1.41843606
51MP0004185_abnormal_adipocyte_glucose1.41700212
52MP0002877_abnormal_melanocyte_morpholog1.41582131
53MP0003136_yellow_coat_color1.39255646
54MP0005584_abnormal_enzyme/coenzyme_acti1.37454344
55MP0010630_abnormal_cardiac_muscle1.33149236
56MP0005620_abnormal_muscle_contractility1.32470882
57MP0000598_abnormal_liver_morphology1.28273880
58MP0003011_delayed_dark_adaptation1.27338369
59MP0003186_abnormal_redox_activity1.27306647
60MP0005171_absent_coat_pigmentation1.25161535
61MP0008932_abnormal_embryonic_tissue1.24636670
62MP0002972_abnormal_cardiac_muscle1.24327177
63MP0000383_abnormal_hair_follicle1.24223915
64MP0004215_abnormal_myocardial_fiber1.22474365
65MP0003077_abnormal_cell_cycle1.21425328
66MP0005187_abnormal_penis_morphology1.19374298
67MP0003567_abnormal_fetal_cardiomyocyte1.19219206
68MP0002332_abnormal_exercise_endurance1.17784253
69MP0002009_preneoplasia1.16846123
70MP0000537_abnormal_urethra_morphology1.14625987
71MP0009703_decreased_birth_body1.14073182
72MP0009643_abnormal_urine_homeostasis1.12910129
73MP0002108_abnormal_muscle_morphology1.12553220
74MP0002254_reproductive_system_inflammat1.11789563
75MP0003656_abnormal_erythrocyte_physiolo1.11604216
76MP0000733_abnormal_muscle_development1.09338751
77MP0005380_embryogenesis_phenotype1.09161535
78MP0001672_abnormal_embryogenesis/_devel1.09161535
79MP0005647_abnormal_sex_gland1.08550626
80MP0001730_embryonic_growth_arrest1.07752687
81MP0005451_abnormal_body_composition1.07429819
82MP0003984_embryonic_growth_retardation1.03435035
83MP0002088_abnormal_embryonic_growth/wei1.03210020
84MP0001727_abnormal_embryo_implantation1.01051651
85MP0009053_abnormal_anal_canal1.00521319
86MP0002697_abnormal_eye_size0.99119896
87* MP0009763_increased_sensitivity_to0.98288060
88MP0004484_altered_response_of0.97940303
89MP0000604_amyloidosis0.96086108
90MP0008995_early_reproductive_senescence0.95194894
91MP0010234_abnormal_vibrissa_follicle0.89924429
92MP0005385_cardiovascular_system_phenoty0.89347384
93MP0001544_abnormal_cardiovascular_syste0.89347384
94MP0000647_abnormal_sebaceous_gland0.87461601
95MP0000762_abnormal_tongue_morphology0.86133207
96MP0001293_anophthalmia0.85902730
97MP0008007_abnormal_cellular_replicative0.84195396
98MP0005266_abnormal_metabolism0.84122625
99MP0005376_homeostasis/metabolism_phenot0.83859445
100MP0001697_abnormal_embryo_size0.81573437
101MP0009764_decreased_sensitivity_to0.81058557
102MP0000377_abnormal_hair_follicle0.79448544
103MP0003123_paternal_imprinting0.79387603
104MP0002796_impaired_skin_barrier0.78796643
105MP0010368_abnormal_lymphatic_system0.77621167
106MP0009765_abnormal_xenobiotic_induced0.76761486
107MP0005670_abnormal_white_adipose0.75268743
108MP0002080_prenatal_lethality0.74706383
109MP0005636_abnormal_mineral_homeostasis0.74340516
110* MP0009642_abnormal_blood_homeostasis0.74219799
111MP0005375_adipose_tissue_phenotype0.73487440
112MP0005408_hypopigmentation0.73396951
113MP0005220_abnormal_exocrine_pancreas0.72812342
114MP0006036_abnormal_mitochondrial_physio0.71864257
115MP0008775_abnormal_heart_ventricle0.70951311
116MP0004381_abnormal_hair_follicle0.70768889
117MP0003699_abnormal_female_reproductive0.70759678
118MP0001661_extended_life_span0.70443983
119MP0010030_abnormal_orbit_morphology0.69970765
120MP0001340_abnormal_eyelid_morphology0.69375392
121MP0008469_abnormal_protein_level0.69202900
122MP0003718_maternal_effect0.68262179
123MP0002084_abnormal_developmental_patter0.68188372
124MP0000467_abnormal_esophagus_morphology0.67803600
125MP0005084_abnormal_gallbladder_morpholo0.67670636
126MP0002085_abnormal_embryonic_tissue0.67417280
127MP0006035_abnormal_mitochondrial_morpho0.66503283
128* MP0002078_abnormal_glucose_homeostasis0.63299068
129MP0002971_abnormal_brown_adipose0.63276591
130MP0005334_abnormal_fat_pad0.57534578
131MP0005395_other_phenotype0.57432704
132MP0004130_abnormal_muscle_cell0.55101074
133MP0009672_abnormal_birth_weight0.54841502
134MP0003453_abnormal_keratinocyte_physiol0.54272231
135MP0004264_abnormal_extraembryonic_tissu0.52813857
136MP0003329_amyloid_beta_deposits0.51757006
137MP0005023_abnormal_wound_healing0.51539965
138MP0001915_intracranial_hemorrhage0.50735153
139MP0000639_abnormal_adrenal_gland0.50095408
140MP0001756_abnormal_urination0.49899964
141MP0001243_abnormal_dermal_layer0.49519938
142MP0002060_abnormal_skin_morphology0.48979933
143MP0008873_increased_physiological_sensi0.48685951
144MP0005248_abnormal_Harderian_gland0.48400311
145MP0005448_abnormal_energy_balance0.46715041
146MP0005666_abnormal_adipose_tissue0.45912660
147MP0010352_gastrointestinal_tract_polyps0.45870244
148MP0009384_cardiac_valve_regurgitation0.44270725
149MP0005501_abnormal_skin_physiology0.42839831
150MP0002928_abnormal_bile_duct0.41351148
151MP0002136_abnormal_kidney_physiology0.40897507
152MP0003638_abnormal_response/metabolism_0.36528700
153MP0005535_abnormal_body_temperature0.36099287
154MP0003690_abnormal_glial_cell0.35678768
155MP0002970_abnormal_white_adipose0.35340488
156MP0003436_decreased_susceptibility_to0.34938018
157MP0002876_abnormal_thyroid_physiology0.34594396
158MP0009115_abnormal_fat_cell0.34201898
159MP0002269_muscular_atrophy0.33617418
160MP0000427_abnormal_hair_cycle0.33202262
161MP0003890_abnormal_embryonic-extraembry0.32549608
162MP0000579_abnormal_nail_morphology0.32260805
163MP0005464_abnormal_platelet_physiology0.31832392
164MP0002168_other_aberrant_phenotype0.30952087
165MP0001881_abnormal_mammary_gland0.30343920
166MP0008874_decreased_physiological_sensi0.29642907
167MP0009931_abnormal_skin_appearance0.29041336
168MP0001853_heart_inflammation0.28831259
169* MP0003953_abnormal_hormone_level0.26918952
170MP0002086_abnormal_extraembryonic_tissu0.26792335
171MP0004197_abnormal_fetal_growth/weight/0.26753595
172MP0003566_abnormal_cell_adhesion0.26717083
173MP0008872_abnormal_physiological_respon0.26599897
174MP0004782_abnormal_surfactant_physiolog0.26562552

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.61638549
2Deep venous thrombosis (HP:0002625)7.45083191
3Abnormality of aromatic amino acid family metabolism (HP:0004338)7.21904007
4Abnormality of monocarboxylic acid metabolism (HP:0010996)7.00775600
5Muscle fiber inclusion bodies (HP:0100299)6.87598630
6Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.62735328
7Hypobetalipoproteinemia (HP:0003563)6.57916492
8Xanthomatosis (HP:0000991)6.39111304
9Nemaline bodies (HP:0003798)6.36140806
10Prolonged partial thromboplastin time (HP:0003645)6.24229850
11Hyperlipoproteinemia (HP:0010980)5.41022752
12Complement deficiency (HP:0004431)5.31372827
13Exercise-induced muscle cramps (HP:0003710)5.29374534
14Exercise-induced myalgia (HP:0003738)5.04647018
15Hypolipoproteinemia (HP:0010981)4.90771986
16Epidermoid cyst (HP:0200040)4.61266135
17Hyperammonemia (HP:0001987)4.58679503
18Hyperglycinemia (HP:0002154)4.52241528
19Joint hemorrhage (HP:0005261)4.51333641
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.46218073
21Abnormality of sulfur amino acid metabolism (HP:0004339)4.44873673
22Abnormality of methionine metabolism (HP:0010901)4.40392951
23Abnormality of the common coagulation pathway (HP:0010990)4.39318696
24Abnormality of pyrimidine metabolism (HP:0004353)4.25070815
25Hypoalphalipoproteinemia (HP:0003233)4.23366126
26Abnormality of aspartate family amino acid metabolism (HP:0010899)4.16819526
27Abnormality of glutamine family amino acid metabolism (HP:0010902)4.16146613
28Fat malabsorption (HP:0002630)4.15703811
29Type 1 muscle fiber predominance (HP:0003803)4.08317106
30Abnormality of complement system (HP:0005339)4.03393124
31Ketosis (HP:0001946)4.01708999
32Hyperglycinuria (HP:0003108)3.93428371
33Abnormality of glycine metabolism (HP:0010895)3.92403434
34Abnormality of serine family amino acid metabolism (HP:0010894)3.92403434
35Hypoglycemic coma (HP:0001325)3.78143699
36Abnormality of the intrinsic pathway (HP:0010989)3.71599860
37Muscle hypertrophy of the lower extremities (HP:0008968)3.64856276
38Abnormality of the calf musculature (HP:0001430)3.62664613
39Hypercholesterolemia (HP:0003124)3.62442935
40Hyporeflexia of lower limbs (HP:0002600)3.55582927
41Calf muscle hypertrophy (HP:0008981)3.46599355
42Conjugated hyperbilirubinemia (HP:0002908)3.42631847
43EMG: myopathic abnormalities (HP:0003458)3.36511591
44Hypochromic microcytic anemia (HP:0004840)3.32957661
45Muscle fiber splitting (HP:0003555)3.25066664
46Rimmed vacuoles (HP:0003805)3.22625438
47Hyperbilirubinemia (HP:0002904)3.21834583
48Papillary thyroid carcinoma (HP:0002895)3.19117136
49Abnormality of serum amino acid levels (HP:0003112)3.15751853
50Steatorrhea (HP:0002570)3.10829494
51Skin nodule (HP:0200036)3.10314578
52Distal lower limb muscle weakness (HP:0009053)3.10047404
53Abnormality of nucleobase metabolism (HP:0010932)3.07951396
54Hepatocellular carcinoma (HP:0001402)3.05735022
55Myocardial infarction (HP:0001658)3.04843601
56Spastic diplegia (HP:0001264)3.04321839
57Abnormality of fatty-acid metabolism (HP:0004359)3.02389261
58Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.99639341
59Delayed CNS myelination (HP:0002188)2.98857590
60Myoglobinuria (HP:0002913)2.98243552
61Neck muscle weakness (HP:0000467)2.96756352
62Abnormality of the left ventricular outflow tract (HP:0011103)2.88071769
63Subaortic stenosis (HP:0001682)2.88071769
64Spontaneous abortion (HP:0005268)2.82064361
65Myopathic facies (HP:0002058)2.80488652
66Asymmetry of the thorax (HP:0001555)2.71337712
67Ketoacidosis (HP:0001993)2.70492682
68Malignant hyperthermia (HP:0002047)2.67851464
69Distal arthrogryposis (HP:0005684)2.66876599
70Rhabdomyolysis (HP:0003201)2.66123250
71Acanthocytosis (HP:0001927)2.64614234
72Bundle branch block (HP:0011710)2.63847994
73Microglossia (HP:0000171)2.53463881
74Vascular calcification (HP:0004934)2.53184380
75Metabolic acidosis (HP:0001942)2.53139952
76Abnormal gallbladder morphology (HP:0012437)2.51560642
77Abnormality of purine metabolism (HP:0004352)2.49391686
78Cholelithiasis (HP:0001081)2.48552261
79Hypoglycemic seizures (HP:0002173)2.48270435
80Chromosomal breakage induced by crosslinking agents (HP:0003221)2.46863605
81Lethargy (HP:0001254)2.46515764
82Esophageal varix (HP:0002040)2.45413975
83Systemic lupus erythematosus (HP:0002725)2.45053299
84Centrally nucleated skeletal muscle fibers (HP:0003687)2.44838252
85Malnutrition (HP:0004395)2.42971446
86Cholecystitis (HP:0001082)2.40650437
87Abnormal gallbladder physiology (HP:0012438)2.40650437
88Chromsome breakage (HP:0040012)2.36834782
89Areflexia of lower limbs (HP:0002522)2.34481964
90Dysmetric saccades (HP:0000641)2.34057895
91Progressive muscle weakness (HP:0003323)2.32876304
92Dicarboxylic aciduria (HP:0003215)2.31751252
93Abnormality of dicarboxylic acid metabolism (HP:0010995)2.31751252
94Gout (HP:0001997)2.31190052
95Neonatal onset (HP:0003623)2.30671329
96Irritability (HP:0000737)2.30633016
97Absent eyebrow (HP:0002223)2.30273132
98Cardiovascular calcification (HP:0011915)2.29813723
99Glomerulonephritis (HP:0000099)2.28063893
100Shoulder girdle muscle weakness (HP:0003547)2.26102788
101Right ventricular cardiomyopathy (HP:0011663)2.23932846
102Difficulty running (HP:0009046)2.22608956
103Thyroid carcinoma (HP:0002890)2.20729349
104Nephroblastoma (Wilms tumor) (HP:0002667)2.19825108
105Distal lower limb amyotrophy (HP:0008944)2.19709637
106Hyperinsulinemic hypoglycemia (HP:0000825)2.17249130
107Mitral stenosis (HP:0001718)2.16153046
108Muscle stiffness (HP:0003552)2.15396085
109EMG: neuropathic changes (HP:0003445)2.14423512
110Increased connective tissue (HP:0009025)2.14203296
111Abnormality of iron homeostasis (HP:0011031)2.13805492
112Cerebral edema (HP:0002181)2.13227202
113Absent eyelashes (HP:0000561)2.12067515
114Insidious onset (HP:0003587)2.12049195
115Termporal pattern (HP:0011008)2.12049195
116Mildly elevated creatine phosphokinase (HP:0008180)2.11219152
117Abnormality of transition element cation homeostasis (HP:0011030)2.09612016
118Abnormal cartilage morphology (HP:0002763)2.09294745
119Poikilocytosis (HP:0004447)2.08160891
120Rickets (HP:0002748)2.07625250
121Hemorrhage of the eye (HP:0011885)2.03888938
122Hypopigmentation of the fundus (HP:0007894)2.03711167
123Pelvic girdle muscle weakness (HP:0003749)2.03033174
124Reticulocytosis (HP:0001923)2.01905010
125Abnormality of the gallbladder (HP:0005264)2.00376790
126Thrombophlebitis (HP:0004418)2.00279816
127Menorrhagia (HP:0000132)2.00212850
128Embryonal renal neoplasm (HP:0011794)1.98834289
129Sensorimotor neuropathy (HP:0007141)1.98299558
130Pseudobulbar signs (HP:0002200)1.98058558
131Gingival bleeding (HP:0000225)1.97355309
132Pancreatitis (HP:0001733)1.96163460
133Septate vagina (HP:0001153)1.94801877
134Abnormality of the Achilles tendon (HP:0005109)1.94417802
135Sudden death (HP:0001699)1.93497366
136Choanal stenosis (HP:0000452)1.93339286
137Calcaneovalgus deformity (HP:0001848)1.93010113
138Asymmetric septal hypertrophy (HP:0001670)1.91601273
139Brushfield spots (HP:0001088)1.91336022
140Opisthotonus (HP:0002179)1.91323017
141Round ear (HP:0100830)1.91302827
142Hydroxyprolinuria (HP:0003080)1.90282673
143Abnormality of proline metabolism (HP:0010907)1.90282673
144Late onset (HP:0003584)1.90222030
145Recurrent gram-negative bacterial infections (HP:0005420)1.89383251
146Back pain (HP:0003418)1.87824547
147Abnormality of skeletal muscle fiber size (HP:0012084)1.87778016
148Upper motor neuron abnormality (HP:0002127)1.86965111
149Abnormal enzyme/coenzyme activity (HP:0012379)1.85405169
150Increased mean platelet volume (HP:0011877)1.85353824
151Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.84968426
152Abnormality of glycolysis (HP:0004366)1.84291114
153Dilated cardiomyopathy (HP:0001644)1.84210586
154Amyloidosis (HP:0011034)1.83623034
155Abnormality of vitamin metabolism (HP:0100508)1.82019713
156Status epilepticus (HP:0002133)1.81463449
157Bifid tongue (HP:0010297)1.81407325
158Abnormality of the hip-girdle musculature (HP:0001445)1.81274286
159Abnormality of the musculature of the pelvis (HP:0001469)1.81274286
160Vomiting (HP:0002013)1.81105140
161Enlarged kidneys (HP:0000105)1.80515191
162Clitoromegaly (HP:0000057)1.80243676
163Increased serum pyruvate (HP:0003542)1.79970232
164White forelock (HP:0002211)1.78928475
165Hypophosphatemic rickets (HP:0004912)1.77794564
166Limb-girdle muscle atrophy (HP:0003797)1.77087430
167Proximal tubulopathy (HP:0000114)1.73267593
168Ulnar deviation of the wrist (HP:0003049)1.72466730
169Multiple enchondromatosis (HP:0005701)1.71804081
170Frequent falls (HP:0002359)1.70375696
171Abnormal lung lobation (HP:0002101)1.70190131
172Proximal amyotrophy (HP:0007126)1.69449687
173Long clavicles (HP:0000890)1.69267321
174Deformed tarsal bones (HP:0008119)1.67896029
175Lip pit (HP:0100267)1.66004133
176Bicornuate uterus (HP:0000813)1.64411745
177Lower limb amyotrophy (HP:0007210)1.63683688
178Progressive external ophthalmoplegia (HP:0000590)1.63379866
179Patchy hypopigmentation of hair (HP:0011365)1.63153235
180Midline defect of the nose (HP:0004122)1.62996125
181Heart block (HP:0012722)1.61062109
182Pancreatic islet-cell hyperplasia (HP:0004510)1.60860861
183Breast carcinoma (HP:0003002)1.59349412
184Breech presentation (HP:0001623)1.58616949
185Abnormal atrioventricular conduction (HP:0005150)1.57680910
186Abnormality of the lacrimal duct (HP:0011481)1.56585286
187Gowers sign (HP:0003391)1.56144170
188Abnormality of the shoulder girdle musculature (HP:0001435)1.55613204
189Gonadotropin excess (HP:0000837)1.55579438
190Aplasia/Hypoplasia of the sternum (HP:0006714)1.54697399
191Myelomeningocele (HP:0002475)1.52345578

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.77410252
2OBSCN5.31096471
3SIK13.88461443
4FGFR43.76452425
5ERN13.64226821
6ERBB43.24094584
7PKN23.13685759
8EIF2AK32.83405378
9EPHA22.80669548
10TTN2.74134325
11LATS12.43804854
12FLT32.25567316
13PHKG22.14182160
14PHKG12.14182160
15CDK122.10616175
16BRSK22.05454585
17TSSK61.98989672
18MAP3K131.97111444
19MAP2K41.90870705
20TRIB31.86697644
21INSRR1.82743854
22BUB11.79128330
23DMPK1.76803299
24TAOK31.75405242
25MAPK111.73021038
26PBK1.70711588
27NEK11.70030549
28SRPK11.69645405
29PTK61.63374417
30ERBB31.57169255
31MST1R1.56812292
32NEK61.55880286
33CDK61.55866478
34STK38L1.37844409
35MAP3K111.33275580
36MAP3K31.32836932
37LATS21.30348068
38PIK3CG1.30094558
39TIE11.29420634
40ICK1.26846476
41MAP3K101.25382072
42MET1.24628355
43PIK3CA1.24012011
44NEK91.23317623
45MKNK21.21941582
46ABL21.19731711
47STK241.17062334
48MAP2K31.15984205
49BRD41.15516739
50BMX1.10946087
51CDK41.09760060
52CDC71.09046470
53TYK21.06403556
54MKNK11.04741257
55MST41.03265320
56MTOR1.03061717
57NME11.01511926
58FRK1.01195326
59KDR1.01135953
60CAMK1D1.01016552
61TTK0.98512906
62MAP3K70.97927031
63MUSK0.97055971
64RPS6KB20.96974201
65PLK30.92249380
66FGFR20.91620846
67STK390.91206787
68PLK10.90258500
69DYRK1B0.89441386
70RIPK10.87993525
71PTK20.87664634
72PDK30.87449010
73PDK40.87449010
74ERBB20.85567133
75TRIM280.84790903
76GRK60.84046599
77EIF2AK20.83414543
78MAPKAPK30.81422772
79JAK20.80549928
80RAF10.79424553
81PRKAA20.75032529
82MAP3K50.73405886
83DYRK30.72981547
84DAPK20.72135956
85RPS6KB10.69713031
86SCYL20.69286189
87EEF2K0.69230882
88MAP3K90.68682527
89TAOK20.67752379
90WEE10.67063321
91TRPM70.66839829
92GSK3A0.66725448
93PAK40.66366991
94EIF2AK10.65110943
95MAPK40.62865178
96STK30.61875635
97ATR0.61615957
98AKT30.61254424
99RPS6KA40.60081677
100MAP3K80.58341745
101FGFR10.57272519
102CLK10.55868342
103PRKCZ0.55468634
104CHUK0.55375198
105CHEK10.55361962
106CDK10.52717971
107MAPK100.52154248
108NUAK10.50976031
109PRKACG0.50690906
110PDGFRA0.50332602
111TESK20.50306453
112CDK70.50000196
113PLK40.49521626
114ATM0.48776411
115PIM10.47775089
116CSK0.47069924
117CDK90.45517191
118CSNK1E0.45475879
119PRKAA10.45433876
120YES10.44212785
121NEK20.43999397
122RPS6KA10.43995174
123ZAK0.43847706
124IRAK30.43845369
125MAP2K10.43563809
126MAPK120.42127969
127BRAF0.42035491
128MAP3K140.40798011
129CHEK20.40714818
130EGFR0.40613993
131BCR0.40304255
132PINK10.39151960
133CDK20.38655635
134PAK20.37454129
135FER0.36948323
136MAPK150.35566193
137MAPK70.35495748
138AKT20.35287144
139MAP3K120.35252762
140CAMK2D0.34711877
141CSNK1D0.33858023
142MAP2K20.33699124
143CAMK2G0.33658765
144ACVR1B0.33222965
145AURKA0.33126869
146TGFBR10.32944111
147PDK20.32712431
148GSK3B0.32375748
149PRKCI0.32111658
150MAP3K60.31681107
151JAK10.31483896
152STK100.31459440
153RET0.30658644
154AURKB0.30299591
155TBK10.30284683
156PRKCG0.29350850
157PAK30.28520732
158IGF1R0.28064332
159GRK10.25329678
160MAP2K60.25216649
161CSNK2A20.25186515

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.44151519
2Nitrogen metabolism_Homo sapiens_hsa009103.86344980
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.56139706
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.31609561
5Arginine biosynthesis_Homo sapiens_hsa002203.13252577
6Complement and coagulation cascades_Homo sapiens_hsa046102.73863222
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.73047668
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.62139683
9Tryptophan metabolism_Homo sapiens_hsa003802.61256610
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.54535217
11Fatty acid degradation_Homo sapiens_hsa000712.38833395
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.26903163
13Circadian rhythm_Homo sapiens_hsa047102.22563806
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.19168308
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.02271448
16Butanoate metabolism_Homo sapiens_hsa006501.96104383
17Peroxisome_Homo sapiens_hsa041461.94356403
18Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.92961315
19Chemical carcinogenesis_Homo sapiens_hsa052041.90091417
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88653850
21Drug metabolism - other enzymes_Homo sapiens_hsa009831.86542005
22PPAR signaling pathway_Homo sapiens_hsa033201.82949727
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.82031436
24Selenocompound metabolism_Homo sapiens_hsa004501.80489542
25Propanoate metabolism_Homo sapiens_hsa006401.78557875
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.77027730
27Histidine metabolism_Homo sapiens_hsa003401.76072452
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.73430281
29Fatty acid metabolism_Homo sapiens_hsa012121.72318997
30Staphylococcus aureus infection_Homo sapiens_hsa051501.65913297
31Retinol metabolism_Homo sapiens_hsa008301.64198900
32beta-Alanine metabolism_Homo sapiens_hsa004101.61894782
33Caffeine metabolism_Homo sapiens_hsa002321.56345491
34Phenylalanine metabolism_Homo sapiens_hsa003601.55699959
35mRNA surveillance pathway_Homo sapiens_hsa030151.53707675
36Bile secretion_Homo sapiens_hsa049761.51843522
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.49026584
38RNA transport_Homo sapiens_hsa030131.45907329
39Cell cycle_Homo sapiens_hsa041101.45597526
40Biosynthesis of amino acids_Homo sapiens_hsa012301.45313212
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44021493
42Tyrosine metabolism_Homo sapiens_hsa003501.41783855
43Pyruvate metabolism_Homo sapiens_hsa006201.37131105
44One carbon pool by folate_Homo sapiens_hsa006701.32932096
45Folate biosynthesis_Homo sapiens_hsa007901.32676235
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28040033
47Carbon metabolism_Homo sapiens_hsa012001.26864557
48Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.25276833
49Thyroid cancer_Homo sapiens_hsa052161.24465710
50Starch and sucrose metabolism_Homo sapiens_hsa005001.23059285
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21599863
52Steroid biosynthesis_Homo sapiens_hsa001001.20423861
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.19957847
54Cyanoamino acid metabolism_Homo sapiens_hsa004601.19611082
55Fat digestion and absorption_Homo sapiens_hsa049751.19377222
56Basal transcription factors_Homo sapiens_hsa030221.19209406
57ABC transporters_Homo sapiens_hsa020101.14018955
58Fatty acid elongation_Homo sapiens_hsa000621.12995325
59Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11473058
60Sulfur metabolism_Homo sapiens_hsa009201.09287583
61Oocyte meiosis_Homo sapiens_hsa041141.05987748
62Vitamin B6 metabolism_Homo sapiens_hsa007501.05232571
63DNA replication_Homo sapiens_hsa030301.02819712
64Tight junction_Homo sapiens_hsa045300.99561052
65Arginine and proline metabolism_Homo sapiens_hsa003300.99380027
66Sulfur relay system_Homo sapiens_hsa041220.96650657
67Dilated cardiomyopathy_Homo sapiens_hsa054140.93181332
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92428462
69Adherens junction_Homo sapiens_hsa045200.92040247
70Lysine degradation_Homo sapiens_hsa003100.90653963
71Mismatch repair_Homo sapiens_hsa034300.89577269
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.87316838
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82796815
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82408115
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81897187
76RNA degradation_Homo sapiens_hsa030180.81453973
77Base excision repair_Homo sapiens_hsa034100.79956988
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77586987
79Nucleotide excision repair_Homo sapiens_hsa034200.73640629
80TGF-beta signaling pathway_Homo sapiens_hsa043500.72658738
81Hippo signaling pathway_Homo sapiens_hsa043900.72062404
82Glutathione metabolism_Homo sapiens_hsa004800.71184310
83Pentose phosphate pathway_Homo sapiens_hsa000300.70877996
84Spliceosome_Homo sapiens_hsa030400.66688655
85* Vitamin digestion and absorption_Homo sapiens_hsa049770.63771228
86Glycerolipid metabolism_Homo sapiens_hsa005610.62706304
87mTOR signaling pathway_Homo sapiens_hsa041500.57881478
88Fatty acid biosynthesis_Homo sapiens_hsa000610.54321617
89Fanconi anemia pathway_Homo sapiens_hsa034600.54154359
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54131594
91Non-homologous end-joining_Homo sapiens_hsa034500.52252374
92Prostate cancer_Homo sapiens_hsa052150.49374828
93Small cell lung cancer_Homo sapiens_hsa052220.47546942
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47337650
95FoxO signaling pathway_Homo sapiens_hsa040680.46543570
96Endometrial cancer_Homo sapiens_hsa052130.46286667
97MicroRNAs in cancer_Homo sapiens_hsa052060.44919198
98Metabolic pathways_Homo sapiens_hsa011000.44757967
99Homologous recombination_Homo sapiens_hsa034400.44525781
100Proteoglycans in cancer_Homo sapiens_hsa052050.44480075
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43539088
102Cardiac muscle contraction_Homo sapiens_hsa042600.41351055
103Prion diseases_Homo sapiens_hsa050200.39418626
104Sphingolipid metabolism_Homo sapiens_hsa006000.36908367
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35833236
106Fructose and mannose metabolism_Homo sapiens_hsa000510.35169749
107Galactose metabolism_Homo sapiens_hsa000520.28530464
108Insulin resistance_Homo sapiens_hsa049310.21656600
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19475996
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.18773620
111Linoleic acid metabolism_Homo sapiens_hsa005910.16157369
112Glucagon signaling pathway_Homo sapiens_hsa049220.12284852
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.12144068
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.11935928
115Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.11177305
116AMPK signaling pathway_Homo sapiens_hsa041520.07711705
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.06777115
118Systemic lupus erythematosus_Homo sapiens_hsa053220.05823418
119Bladder cancer_Homo sapiens_hsa052190.02014593
120Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.2248696
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.2219022
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.2098403
123Arachidonic acid metabolism_Homo sapiens_hsa00590-0.2071979
124Hepatitis C_Homo sapiens_hsa05160-0.2017118
125p53 signaling pathway_Homo sapiens_hsa04115-0.1978486
126Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1945754
127Amoebiasis_Homo sapiens_hsa05146-0.1926811
128Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1802861
129Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1398721
130Pyrimidine metabolism_Homo sapiens_hsa00240-0.1308182
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.1252240
132Insulin signaling pathway_Homo sapiens_hsa04910-0.0946758
133Renin-angiotensin system_Homo sapiens_hsa04614-0.0891104
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0525405
135Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0231497
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0069857

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