SLC1A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)6.74215397
2locomotory exploration behavior (GO:0035641)6.58381123
3epoxygenase P450 pathway (GO:0019373)6.34411703
4neuron cell-cell adhesion (GO:0007158)5.84845552
5regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.74525025
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.12724903
7cellular glucuronidation (GO:0052695)5.12339506
8lipoprotein transport (GO:0042953)5.02311391
9vocalization behavior (GO:0071625)5.01679525
10regulation of short-term neuronal synaptic plasticity (GO:0048172)5.00210894
11exploration behavior (GO:0035640)4.92626171
12exogenous drug catabolic process (GO:0042738)4.90626869
13glucuronate metabolic process (GO:0019585)4.87637246
14uronic acid metabolic process (GO:0006063)4.87637246
15drug catabolic process (GO:0042737)4.80863692
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.78404127
17drug metabolic process (GO:0017144)4.72513499
18urea metabolic process (GO:0019627)4.66349400
19regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.65129982
20regulation of bile acid biosynthetic process (GO:0070857)4.62494020
21intestinal absorption (GO:0050892)4.52366318
22urea cycle (GO:0000050)4.44443351
23hormone catabolic process (GO:0042447)4.35094916
24synaptic vesicle exocytosis (GO:0016079)4.34463721
25glutamate secretion (GO:0014047)4.29184381
26regulation of glutamate receptor signaling pathway (GO:1900449)4.27523556
27regulation of guanylate cyclase activity (GO:0031282)4.26810090
28nitrogen cycle metabolic process (GO:0071941)4.25976956
29fat-soluble vitamin biosynthetic process (GO:0042362)4.24595015
30bile acid and bile salt transport (GO:0015721)4.24111201
31omega-hydroxylase P450 pathway (GO:0097267)4.21012554
32glutamate receptor signaling pathway (GO:0007215)4.20137802
33protein localization to synapse (GO:0035418)4.17008205
34NADH metabolic process (GO:0006734)4.16240931
35regulation of synaptic vesicle exocytosis (GO:2000300)4.14035188
36regulation of triglyceride catabolic process (GO:0010896)4.11548171
37synaptic vesicle maturation (GO:0016188)4.08080301
38positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.05382587
39transmission of nerve impulse (GO:0019226)3.99992246
40presynaptic membrane assembly (GO:0097105)3.98718518
41synaptic transmission, glutamatergic (GO:0035249)3.98251073
42neuronal action potential propagation (GO:0019227)3.93299686
43neuron-neuron synaptic transmission (GO:0007270)3.91310919
44neuron recognition (GO:0008038)3.91287283
45long-term synaptic potentiation (GO:0060291)3.90715585
46regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.87810002
47dendritic spine morphogenesis (GO:0060997)3.86570919
48regulation of long-term neuronal synaptic plasticity (GO:0048169)3.78770857
49neurotransmitter-gated ion channel clustering (GO:0072578)3.77533537
50positive regulation of membrane potential (GO:0045838)3.73014949
51flavonoid metabolic process (GO:0009812)3.71894179
52regulation of synaptic vesicle transport (GO:1902803)3.70076100
53regulation of neuronal synaptic plasticity (GO:0048168)3.70030758
54bile acid metabolic process (GO:0008206)3.69092818
55renal system process involved in regulation of blood volume (GO:0001977)3.68810400
56regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.66744063
57endocrine process (GO:0050886)3.66744063
58regulation of systemic arterial blood pressure by hormone (GO:0001990)3.66744063
59postsynaptic membrane organization (GO:0001941)3.65499896
60positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.63834703
61neurotransmitter secretion (GO:0007269)3.60929073
62synaptic vesicle docking involved in exocytosis (GO:0016081)3.60105234
63presynaptic membrane organization (GO:0097090)3.57374966
64axonal fasciculation (GO:0007413)3.56179505
65alkaloid metabolic process (GO:0009820)3.51214399
66startle response (GO:0001964)3.47865212
67gamma-aminobutyric acid signaling pathway (GO:0007214)3.47636335
68long-term memory (GO:0007616)3.45633829
69fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.43981938
70regulation of excitatory postsynaptic membrane potential (GO:0060079)3.41270338
71phospholipid efflux (GO:0033700)3.38036032
72response to histamine (GO:0034776)3.37738396
73drug transmembrane transport (GO:0006855)3.37701134
74neuronal ion channel clustering (GO:0045161)3.36951515
75very-low-density lipoprotein particle assembly (GO:0034379)3.35248447
76positive regulation of guanylate cyclase activity (GO:0031284)3.35114263
77regulation of synaptic plasticity (GO:0048167)3.31126622
78adhesion of symbiont to host cell (GO:0044650)3.31120474
79virion attachment to host cell (GO:0019062)3.31120474
80fructose metabolic process (GO:0006000)3.30818473
81regulation of synaptic transmission, glutamatergic (GO:0051966)3.28296368
82neurotransmitter transport (GO:0006836)3.26382368
83regulation of dendritic spine morphogenesis (GO:0061001)3.25371374
84regulation of systemic arterial blood pressure (GO:0003073)3.25035081
85cellular potassium ion homeostasis (GO:0030007)3.23006485
86nucleobase catabolic process (GO:0046113)3.22019401
87regulation of postsynaptic membrane potential (GO:0060078)3.21336653
88negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.21154671
89gamma-aminobutyric acid transport (GO:0015812)3.19831792
90regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.16292467
91regulation of synapse structural plasticity (GO:0051823)3.11851762
92positive regulation of synapse maturation (GO:0090129)3.09873392
93dendrite morphogenesis (GO:0048813)3.08297717
94drug transport (GO:0015893)3.08293639
95* L-amino acid import (GO:0043092)3.06789179
96layer formation in cerebral cortex (GO:0021819)3.03267288
97neuromuscular process controlling balance (GO:0050885)3.02792556
98* amino acid import (GO:0043090)3.00550405
99plasma lipoprotein particle assembly (GO:0034377)3.00186872
100negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.99076701
101regulation of cholesterol esterification (GO:0010872)2.98118648
102lipoprotein metabolic process (GO:0042157)2.97878331
103behavioral defense response (GO:0002209)2.97598919
104behavioral fear response (GO:0001662)2.97598919
105renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.96017872
106ethanol oxidation (GO:0006069)2.95866481
107peptide hormone processing (GO:0016486)2.94790792
108receptor guanylyl cyclase signaling pathway (GO:0007168)2.94672059
109learning (GO:0007612)2.94420114
110sodium ion homeostasis (GO:0055078)2.93836171
111cellular response to nitric oxide (GO:0071732)2.93808137
112midgut development (GO:0007494)2.90338133
113regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.89293581
114triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.89129042
115regulation of neurotransmitter levels (GO:0001505)2.89020016
116phosphate ion transmembrane transport (GO:0035435)2.87271875
117positive regulation of pseudopodium assembly (GO:0031274)2.87097550
118positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.86928587
119membrane hyperpolarization (GO:0060081)2.86583183
120positive regulation of lipoprotein lipase activity (GO:0051006)2.86099056
121positive regulation of triglyceride lipase activity (GO:0061365)2.86099056
122membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.84957852
123regulation of cGMP biosynthetic process (GO:0030826)2.84917948
124negative regulation of synaptic transmission, GABAergic (GO:0032229)2.84809437
125adhesion of symbiont to host (GO:0044406)2.84002206
126G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.83717612
127heme transport (GO:0015886)2.83114617
128energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.81319994
129ATP hydrolysis coupled proton transport (GO:0015991)2.81319994
130cerebellar granule cell differentiation (GO:0021707)2.80592962
131neuron remodeling (GO:0016322)2.80476453
132positive regulation of synaptic transmission, GABAergic (GO:0032230)2.79933276
133regulation of neuron projection regeneration (GO:0070570)2.79817778
134regulation of axon regeneration (GO:0048679)2.79817778
135synapse assembly (GO:0007416)2.79806836
136protein-lipid complex assembly (GO:0065005)2.79620675
137regulation of neurotransmitter secretion (GO:0046928)2.79273270
138dendritic spine organization (GO:0097061)2.78760159
139synapse organization (GO:0050808)2.78134541
140positive regulation of synapse assembly (GO:0051965)2.77580022
141positive regulation of synaptic transmission (GO:0050806)2.76099787
142negative regulation of axon extension (GO:0030517)2.75786819
143cellular response to ammonium ion (GO:0071242)2.75140282
144high-density lipoprotein particle remodeling (GO:0034375)2.74996714
145fear response (GO:0042596)2.74695681
146positive regulation of lipid catabolic process (GO:0050996)2.74511497
147regulation of dendritic spine development (GO:0060998)2.73959890
148glutamine family amino acid biosynthetic process (GO:0009084)2.73287339
149activated T cell proliferation (GO:0050798)2.72089309
150proline transport (GO:0015824)2.72071314
151long term synaptic depression (GO:0060292)2.71386924
152regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.70923651
153neuromuscular process controlling posture (GO:0050884)2.70109665
154positive regulation of neurotransmitter secretion (GO:0001956)2.69773234
155cholesterol efflux (GO:0033344)2.69570066
156regulation of protein activation cascade (GO:2000257)2.69275745
157neuromuscular process (GO:0050905)2.69020702
158transferrin transport (GO:0033572)2.68929648
159regulation of synapse maturation (GO:0090128)2.67515501
160sodium ion export (GO:0071436)2.67455611
161phenylpropanoid metabolic process (GO:0009698)2.66355297
162drinking behavior (GO:0042756)2.66153453
163auditory behavior (GO:0031223)2.66115671
164diacylglycerol metabolic process (GO:0046339)2.65795666
165regulation of synaptic transmission (GO:0050804)2.65067956
166digestion (GO:0007586)2.64156472
167regulation of female receptivity (GO:0045924)2.63466159
168regulation of vesicle fusion (GO:0031338)2.62980899
169innervation (GO:0060384)2.61332846
170cellular response to reactive nitrogen species (GO:1902170)2.60468573
171phosphate ion transport (GO:0006817)2.60398027
172negative regulation of sterol transport (GO:0032372)2.58640972
173negative regulation of cholesterol transport (GO:0032375)2.58640972
174actin filament depolymerization (GO:0030042)2.56502355
175regulation of cholesterol homeostasis (GO:2000188)2.54590905
176maintenance of gastrointestinal epithelium (GO:0030277)2.53488638
177protein-lipid complex remodeling (GO:0034368)2.51446521
178macromolecular complex remodeling (GO:0034367)2.51446521
179plasma lipoprotein particle remodeling (GO:0034369)2.51446521
180regulation of complement activation (GO:0030449)2.51359086
181arginine metabolic process (GO:0006525)2.48608672
182regulation of pseudopodium assembly (GO:0031272)2.48316575
183reverse cholesterol transport (GO:0043691)2.47847510
184fat-soluble vitamin metabolic process (GO:0006775)2.47101177
185homocysteine metabolic process (GO:0050667)2.46219573
186neurotransmitter biosynthetic process (GO:0042136)2.46170915
187iron coordination entity transport (GO:1901678)2.43760699
188glycosylceramide metabolic process (GO:0006677)2.43726236
189oxidative demethylation (GO:0070989)2.42836899
190coenzyme catabolic process (GO:0009109)2.40145358
191complement activation, alternative pathway (GO:0006957)2.39852635
192vitamin transport (GO:0051180)2.39037767
193vitamin biosynthetic process (GO:0009110)2.38895809
194cholesterol homeostasis (GO:0042632)2.37393379
195cGMP biosynthetic process (GO:0006182)2.36059569

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.58635805
2GBX2_23144817_ChIP-Seq_PC3_Human3.82296810
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.57335806
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.19363370
5CDX2_20551321_ChIP-Seq_CACO-2_Human3.09952910
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07608362
7JARID2_20064375_ChIP-Seq_MESCs_Mouse3.04219955
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.94825263
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59669622
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.55210545
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.55210545
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47591124
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45700557
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.39876546
15* REST_21632747_ChIP-Seq_MESCs_Mouse2.37456950
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.37327709
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34525710
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31809495
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.31169420
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11880845
21DROSHA_22980978_ChIP-Seq_HELA_Human2.11756799
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11321189
23RARB_27405468_Chip-Seq_BRAIN_Mouse2.09410325
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.09206897
25TAF15_26573619_Chip-Seq_HEK293_Human2.07300621
26AR_21572438_ChIP-Seq_LNCaP_Human2.04510569
27CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00916449
28RNF2_27304074_Chip-Seq_ESCs_Mouse2.00385811
29RXR_22158963_ChIP-Seq_LIVER_Mouse1.99892594
30LXR_22158963_ChIP-Seq_LIVER_Mouse1.94339322
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.93837998
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89418836
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.85117495
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.82793488
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75884907
36ZNF274_21170338_ChIP-Seq_K562_Hela1.72631608
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72308911
38TCF4_18268006_ChIP-ChIP_LS174T_Human1.69586534
39* SMAD4_21799915_ChIP-Seq_A2780_Human1.66319707
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.65282785
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.63258358
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61982536
43NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.61920403
44* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61519992
45* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57675069
46P300_19829295_ChIP-Seq_ESCs_Human1.57616462
47EGR1_23403033_ChIP-Seq_LIVER_Mouse1.57197964
48* SOX2_20726797_ChIP-Seq_SW620_Human1.55997965
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55508883
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.54035207
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51442772
52FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48112602
53* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47046252
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47016891
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45330192
56* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44416984
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44184503
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.41962459
59GATA4_25053715_ChIP-Seq_YYC3_Human1.41811118
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.40853677
61BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.40607075
62SOX2_27498859_Chip-Seq_STOMACH_Mouse1.40094488
63* SMAD3_21741376_ChIP-Seq_EPCs_Human1.38947026
64PPARA_22158963_ChIP-Seq_LIVER_Mouse1.38380487
65FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.37975569
66AR_25329375_ChIP-Seq_VCAP_Human1.35473641
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.34210548
68TP63_17297297_ChIP-ChIP_HaCaT_Human1.33661745
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32549810
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31990855
71VDR_22108803_ChIP-Seq_LS180_Human1.31103442
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27736823
73BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25807843
74SOX2_21211035_ChIP-Seq_LN229_Gbm1.25646309
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24128470
76* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.23985785
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.23335352
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.22896263
79AHR_22903824_ChIP-Seq_MCF-7_Human1.21882603
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20907383
81FUS_26573619_Chip-Seq_HEK293_Human1.20335729
82MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19327832
83RING1B_27294783_Chip-Seq_ESCs_Mouse1.18778706
84PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18661027
85ER_23166858_ChIP-Seq_MCF-7_Human1.18641772
86EP300_21415370_ChIP-Seq_HL-1_Mouse1.18346576
87POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18133621
88STAT3_23295773_ChIP-Seq_U87_Human1.17748576
89ARNT_22903824_ChIP-Seq_MCF-7_Human1.17486555
90FOXA2_19822575_ChIP-Seq_HepG2_Human1.17485644
91CLOCK_20551151_ChIP-Seq_293T_Human1.17084956
92* PRDM14_20953172_ChIP-Seq_ESCs_Human1.16774337
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16416485
94RNF2_27304074_Chip-Seq_NSC_Mouse1.16197868
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13919429
96NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13919429
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12621096
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12471385
99P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11324137
100TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.10026390
101* RUNX2_22187159_ChIP-Seq_PCA_Human1.09949032
102THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09925072
103* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09758212
104PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.09434571
105* SMAD3_21741376_ChIP-Seq_HESCs_Human1.08904013
106FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06525072
107AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06385549
108TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05647597
109TCF4_23295773_ChIP-Seq_U87_Human1.05186274
110HNF4A_19822575_ChIP-Seq_HepG2_Human1.05156672
111TP53_16413492_ChIP-PET_HCT116_Human1.04282709
112RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04243547
113ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02821542
114* FOXO3_23340844_ChIP-Seq_DLD1_Human1.01976608
115WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01154859
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00918184
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00918184
118CJUN_26792858_Chip-Seq_BT549_Human1.00549478
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00242132
120TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00187400
121RXR_22108803_ChIP-Seq_LS180_Human1.00004070
122* RING1B_27294783_Chip-Seq_NPCs_Mouse0.99684302
123* AR_19668381_ChIP-Seq_PC3_Human0.97659448
124* CDX2_22108803_ChIP-Seq_LS180_Human0.97209382
125NANOG_18555785_Chip-Seq_ESCs_Mouse0.96981943
126* SMAD4_21741376_ChIP-Seq_HESCs_Human0.96655137
127* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95165809
128ESR2_21235772_ChIP-Seq_MCF-7_Human0.95155802
129SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.94680098
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93376497
131KDM2B_26808549_Chip-Seq_REH_Human0.92626916
132PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92607633
133STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91165079
134PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90807143
135YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90358118
136GATA6_25053715_ChIP-Seq_YYC3_Human0.90317991
137E2F1_18555785_Chip-Seq_ESCs_Mouse0.89992782
138IGF1R_20145208_ChIP-Seq_DFB_Human0.89497793
139TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88640572
140TP63_23658742_ChIP-Seq_EP156T_Human0.88439594
141ESR1_21235772_ChIP-Seq_MCF-7_Human0.86572803
142BCAT_22108803_ChIP-Seq_LS180_Human0.86462673
143JUN_21703547_ChIP-Seq_K562_Human0.86422237
144TP53_18474530_ChIP-ChIP_U2OS_Human0.85975619

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.64532759
2MP0003880_abnormal_central_pattern5.25524718
3MP0002139_abnormal_hepatobiliary_system5.00529852
4MP0005085_abnormal_gallbladder_physiolo4.92541018
5MP0001666_abnormal_nutrient_absorption4.05145904
6MP0005365_abnormal_bile_salt4.03220672
7MP0003635_abnormal_synaptic_transmissio3.79383883
8MP0009745_abnormal_behavioral_response3.37548839
9MP0004270_analgesia3.36204587
10MP0003183_abnormal_peptide_metabolism3.34195683
11MP0002064_seizures3.21219169
12MP0002063_abnormal_learning/memory/cond3.07016089
13MP0009046_muscle_twitch3.01930318
14MP0009840_abnormal_foam_cell2.90687799
15MP0001486_abnormal_startle_reflex2.82539796
16MP0002572_abnormal_emotion/affect_behav2.69565783
17MP0003868_abnormal_feces_composition2.57267080
18MP0002822_catalepsy2.56832709
19MP0001968_abnormal_touch/_nociception2.54089551
20* MP0002272_abnormal_nervous_system2.50295996
21MP0001440_abnormal_grooming_behavior2.49671434
22MP0002734_abnormal_mechanical_nocicepti2.31143860
23MP0005423_abnormal_somatic_nervous2.28113369
24MP0004885_abnormal_endolymph2.26775537
25MP0003252_abnormal_bile_duct2.19295778
26MP0001501_abnormal_sleep_pattern2.14919770
27MP0004264_abnormal_extraembryonic_tissu2.11940251
28MP0003329_amyloid_beta_deposits2.11699486
29MP0002736_abnormal_nociception_after2.11155684
30MP0008875_abnormal_xenobiotic_pharmacok2.10107725
31MP0000778_abnormal_nervous_system2.07402534
32MP0002735_abnormal_chemical_nociception2.00603949
33MP0010329_abnormal_lipoprotein_level1.97184610
34MP0002067_abnormal_sensory_capabilities1.95424101
35MP0004043_abnormal_pH_regulation1.81428571
36MP0008438_abnormal_cutaneous_collagen1.78481704
37MP0010234_abnormal_vibrissa_follicle1.72377516
38MP0001970_abnormal_pain_threshold1.69283459
39MP0004742_abnormal_vestibular_system1.68901966
40MP0001529_abnormal_vocalization1.65813607
41MP0002138_abnormal_hepatobiliary_system1.63841231
42MP0002733_abnormal_thermal_nociception1.62962224
43MP0005670_abnormal_white_adipose1.62279676
44MP0002557_abnormal_social/conspecific_i1.62017736
45MP0010386_abnormal_urinary_bladder1.60467515
46MP0004272_abnormal_basement_membrane1.59589743
47MP0001905_abnormal_dopamine_level1.55355330
48MP0003879_abnormal_hair_cell1.51249618
49MP0002876_abnormal_thyroid_physiology1.49117411
50MP0001984_abnormal_olfaction1.49077347
51MP0003690_abnormal_glial_cell1.48850146
52MP0009780_abnormal_chondrocyte_physiolo1.46547798
53MP0004924_abnormal_behavior1.45931645
54MP0005386_behavior/neurological_phenoty1.45931645
55MP0002184_abnormal_innervation1.45341646
56MP0000920_abnormal_myelination1.43289819
57MP0008569_lethality_at_weaning1.42646047
58* MP0002066_abnormal_motor_capabilities/c1.39941169
59MP0004782_abnormal_surfactant_physiolog1.39400540
60MP0000538_abnormal_urinary_bladder1.39118248
61MP0001188_hyperpigmentation1.35144728
62* MP0002882_abnormal_neuron_morphology1.33100260
63MP0010352_gastrointestinal_tract_polyps1.32979862
64MP0001485_abnormal_pinna_reflex1.32568450
65MP0005646_abnormal_pituitary_gland1.32404040
66MP0004858_abnormal_nervous_system1.31915958
67MP0009379_abnormal_foot_pigmentation1.30139139
68MP0006276_abnormal_autonomic_nervous1.26907494
69MP0005171_absent_coat_pigmentation1.26350312
70* MP0009643_abnormal_urine_homeostasis1.25964481
71MP0000955_abnormal_spinal_cord1.25338670
72MP0004142_abnormal_muscle_tone1.24253931
73MP0005409_darkened_coat_color1.23937753
74MP0001963_abnormal_hearing_physiology1.22670598
75MP0005377_hearing/vestibular/ear_phenot1.22102852
76MP0003878_abnormal_ear_physiology1.22102852
77MP0001765_abnormal_ion_homeostasis1.20787341
78MP0004811_abnormal_neuron_physiology1.16135482
79MP0005551_abnormal_eye_electrophysiolog1.15789990
80MP0005645_abnormal_hypothalamus_physiol1.14916988
81MP0001177_atelectasis1.12130109
82MP0003633_abnormal_nervous_system1.11937209
83MP0003631_nervous_system_phenotype1.09220244
84MP0002118_abnormal_lipid_homeostasis1.07806429
85MP0004145_abnormal_muscle_electrophysio1.06984044
86MP0002229_neurodegeneration1.04382876
87MP0003634_abnormal_glial_cell1.02962749
88MP0002152_abnormal_brain_morphology1.02062237
89MP0004019_abnormal_vitamin_homeostasis1.00972451
90MP0001958_emphysema1.00606077
91MP0003632_abnormal_nervous_system0.99494115
92MP0002909_abnormal_adrenal_gland0.99058601
93MP0002069_abnormal_eating/drinking_beha0.96028009
94MP0001502_abnormal_circadian_rhythm0.92588583
95MP0005636_abnormal_mineral_homeostasis0.91148204
96MP0005167_abnormal_blood-brain_barrier0.89712257
97MP0001764_abnormal_homeostasis0.89261182
98MP0003136_yellow_coat_color0.88975955
99MP0005623_abnormal_meninges_morphology0.88892621
100* MP0002752_abnormal_somatic_nervous0.87998641
101MP0003941_abnormal_skin_development0.87014762
102MP0004484_altered_response_of0.86528569
103MP0002136_abnormal_kidney_physiology0.85343176
104MP0010155_abnormal_intestine_physiology0.83488894
105MP0000604_amyloidosis0.81552656
106MP0005535_abnormal_body_temperature0.81089155
107MP0005332_abnormal_amino_acid0.80585212
108MP0003938_abnormal_ear_development0.80522848
109MP0003787_abnormal_imprinting0.80320467
110MP0004147_increased_porphyrin_level0.80099922
111MP0005166_decreased_susceptibility_to0.79224944
112MP0001661_extended_life_span0.78235354
113MP0002896_abnormal_bone_mineralization0.77889158
114MP0005275_abnormal_skin_tensile0.75425984
115MP0005584_abnormal_enzyme/coenzyme_acti0.75286991
116MP0000026_abnormal_inner_ear0.74912342
117MP0008872_abnormal_physiological_respon0.74874913
118MP0008874_decreased_physiological_sensi0.73625410
119MP0002090_abnormal_vision0.73513263
120MP0008004_abnormal_stomach_pH0.72936948
121MP0000631_abnormal_neuroendocrine_gland0.72269506
122MP0000477_abnormal_intestine_morphology0.71203847
123MP0002971_abnormal_brown_adipose0.70844975
124MP0005257_abnormal_intraocular_pressure0.70737473
125MP0005448_abnormal_energy_balance0.70672824
126MP0004215_abnormal_myocardial_fiber0.70473735
127MP0004085_abnormal_heartbeat0.68287670
128MP0000609_abnormal_liver_physiology0.67945145
129MP0003283_abnormal_digestive_organ0.67779263
130MP0003191_abnormal_cellular_cholesterol0.67528333
131MP0000751_myopathy0.66576927
132MP0003172_abnormal_lysosome_physiology0.65089864
133MP0001756_abnormal_urination0.64961776
134MP0005360_urolithiasis0.64673108
135MP0009384_cardiac_valve_regurgitation0.64033475
136MP0000462_abnormal_digestive_system0.63639643
137MP0001664_abnormal_digestion0.63631411
138MP0003091_abnormal_cell_migration0.62969817
139MP0003705_abnormal_hypodermis_morpholog0.62814747
140MP0000537_abnormal_urethra_morphology0.62689720
141MP0000534_abnormal_ureter_morphology0.60956220
142MP0005084_abnormal_gallbladder_morpholo0.57974791
143MP0003195_calcinosis0.57135902
144MP0003122_maternal_imprinting0.56760893
145MP0010368_abnormal_lymphatic_system0.56586463
146MP0005595_abnormal_vascular_smooth0.55172845
147MP0000230_abnormal_systemic_arterial0.54987027
148MP0000566_synostosis0.54658784
149MP0000747_muscle_weakness0.54405506
150MP0003718_maternal_effect0.51833354
151MP0002254_reproductive_system_inflammat0.50655881
152MP0009642_abnormal_blood_homeostasis0.48480744

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)8.40614226
2Focal motor seizures (HP:0011153)7.34426290
3Hydroxyprolinuria (HP:0003080)5.98485169
4Abnormality of proline metabolism (HP:0010907)5.98485169
5Hypobetalipoproteinemia (HP:0003563)5.81287009
6Abnormality of monocarboxylic acid metabolism (HP:0010996)5.31629407
7Myokymia (HP:0002411)5.07535448
8Focal seizures (HP:0007359)4.97659664
9Increased circulating renin level (HP:0000848)4.89418890
10Atonic seizures (HP:0010819)4.88074278
11Malnutrition (HP:0004395)4.67735418
12Fat malabsorption (HP:0002630)4.45884233
13Visual hallucinations (HP:0002367)4.28327642
14Metabolic alkalosis (HP:0200114)4.20604722
15Epileptic encephalopathy (HP:0200134)3.97637020
16Hypomagnesemia (HP:0002917)3.93508144
17Conjugated hyperbilirubinemia (HP:0002908)3.92210853
18Febrile seizures (HP:0002373)3.83680918
19Absence seizures (HP:0002121)3.79663669
20Complement deficiency (HP:0004431)3.79094657
21Dialeptic seizures (HP:0011146)3.78054010
22Hyperventilation (HP:0002883)3.76911151
23Abnormality of the vitamin B12 metabolism (HP:0004341)3.68300590
24Hypokalemic alkalosis (HP:0001949)3.60905285
25Abnormality of magnesium homeostasis (HP:0004921)3.42613207
26Abnormality of vitamin metabolism (HP:0100508)3.41927820
27Gout (HP:0001997)3.41363430
28Abnormal eating behavior (HP:0100738)3.39577753
29Hyperactive renin-angiotensin system (HP:0000841)3.39209090
30Abnormality of vitamin B metabolism (HP:0004340)3.37043462
31Intrahepatic cholestasis (HP:0001406)3.34815786
32Broad-based gait (HP:0002136)3.29326139
33Hypolipoproteinemia (HP:0010981)3.28773859
34Abnormality of complement system (HP:0005339)3.27033545
35Systemic lupus erythematosus (HP:0002725)3.25527278
36Progressive cerebellar ataxia (HP:0002073)3.25401568
37Acanthocytosis (HP:0001927)3.22756879
38Generalized tonic-clonic seizures (HP:0002069)3.17690800
39Widely patent fontanelles and sutures (HP:0004492)3.12900797
40Fetal akinesia sequence (HP:0001989)3.08440662
41Mutism (HP:0002300)3.07995631
42Proximal tubulopathy (HP:0000114)2.98330551
43Polyphagia (HP:0002591)2.96358672
44Polyuria (HP:0000103)2.95681110
45Steatorrhea (HP:0002570)2.90128231
46Xanthomatosis (HP:0000991)2.89850697
47Nephrolithiasis (HP:0000787)2.86612384
48Focal segmental glomerulosclerosis (HP:0000097)2.84697556
49Neurofibrillary tangles (HP:0002185)2.84172367
50Hyperaldosteronism (HP:0000859)2.83227709
51Ileus (HP:0002595)2.79534418
52Abnormal urine output (HP:0012590)2.77377275
53Chronic diarrhea (HP:0002028)2.77055877
54Abnormality of urine glucose concentration (HP:0011016)2.74766433
55Glycosuria (HP:0003076)2.74766433
56Dysmetria (HP:0001310)2.72332028
57Abnormality of serine family amino acid metabolism (HP:0010894)2.71451938
58Abnormality of glycine metabolism (HP:0010895)2.71451938
59Pigmentary retinal degeneration (HP:0001146)2.70268058
60Abnormality of renin-angiotensin system (HP:0000847)2.70159426
61Dysdiadochokinesis (HP:0002075)2.68791258
62Supranuclear gaze palsy (HP:0000605)2.66296181
63Action tremor (HP:0002345)2.64731122
64Polydipsia (HP:0001959)2.60196948
65Abnormal drinking behavior (HP:0030082)2.60196948
66Abnormality of renal excretion (HP:0011036)2.59699152
67Cerebral inclusion bodies (HP:0100314)2.59055686
68Gaze-evoked nystagmus (HP:0000640)2.57801900
69Excessive salivation (HP:0003781)2.56238425
70Drooling (HP:0002307)2.56238425
71Generalized myoclonic seizures (HP:0002123)2.56014350
72Intention tremor (HP:0002080)2.47582654
73Abnormality of the corticospinal tract (HP:0002492)2.46216502
74Abdominal distention (HP:0003270)2.45908900
75Tetany (HP:0001281)2.45050425
76Abnormality of chloride homeostasis (HP:0011422)2.44946779
77Thin bony cortex (HP:0002753)2.44775783
78Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.39200709
79Epidermoid cyst (HP:0200040)2.38517831
80Impaired social interactions (HP:0000735)2.36874539
81Abnormal social behavior (HP:0012433)2.36874539
82Facial shape deformation (HP:0011334)2.36121524
83Potter facies (HP:0002009)2.36121524
84Cardiovascular calcification (HP:0011915)2.36052636
85Poor eye contact (HP:0000817)2.35156082
86Abnormality of purine metabolism (HP:0004352)2.34327975
87Confusion (HP:0001289)2.33578359
88Scanning speech (HP:0002168)2.33210780
89Deep venous thrombosis (HP:0002625)2.32126751
90Renal salt wasting (HP:0000127)2.32048858
91Amblyopia (HP:0000646)2.31525756
92Anxiety (HP:0000739)2.29352131
93Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.27543969
94Degeneration of the lateral corticospinal tracts (HP:0002314)2.27543969
95Abnormality of nucleobase metabolism (HP:0010932)2.27519663
96Hemorrhage of the eye (HP:0011885)2.25834401
97Inability to walk (HP:0002540)2.25152961
98Wide cranial sutures (HP:0010537)2.25146406
99Peripheral hypomyelination (HP:0007182)2.24972737
100Diplopia (HP:0000651)2.24898932
101Abnormality of binocular vision (HP:0011514)2.24898932
102Ankle clonus (HP:0011448)2.23782109
103Insidious onset (HP:0003587)2.21927356
104Termporal pattern (HP:0011008)2.21927356
105Postural instability (HP:0002172)2.21301973
106Glomerulonephritis (HP:0000099)2.18652488
107Nephritis (HP:0000123)2.16781385
108Hyperammonemia (HP:0001987)2.16753989
109Protrusio acetabuli (HP:0003179)2.15213151
110Truncal ataxia (HP:0002078)2.14589870
111Vascular calcification (HP:0004934)2.13582761
112Progressive inability to walk (HP:0002505)2.12992793
113Abnormality of pyrimidine metabolism (HP:0004353)2.12665164
114Delusions (HP:0000746)2.12007043
115Limb dystonia (HP:0002451)2.11572401
116Impaired vibration sensation in the lower limbs (HP:0002166)2.11222723
117Hemiparesis (HP:0001269)2.10899959
118Absent speech (HP:0001344)2.10448143
119Glomerulosclerosis (HP:0000096)2.07556035
120Hypophosphatemia (HP:0002148)2.06660968
121Ventricular fibrillation (HP:0001663)2.06578832
122Spastic gait (HP:0002064)2.05312720
123Increased purine levels (HP:0004368)2.05030682
124Hyperuricemia (HP:0002149)2.05030682
125Abnormal urine phosphate concentration (HP:0012599)2.04872792
126Depression (HP:0000716)2.03570164
127Stereotypic behavior (HP:0000733)2.02673236
128Osteomalacia (HP:0002749)2.01450071
129Epileptiform EEG discharges (HP:0011182)2.00559419
130Congenital sensorineural hearing impairment (HP:0008527)2.00426348
131Hyperlipoproteinemia (HP:0010980)2.00248846
132Akinesia (HP:0002304)1.97093497
133Enlarged epiphyses (HP:0010580)1.97030385
134Abnormality of aspartate family amino acid metabolism (HP:0010899)1.96432656
135Megaloblastic anemia (HP:0001889)1.96249370
136Premature rupture of membranes (HP:0001788)1.95721659
137Absent hand (HP:0004050)1.94429675
138Abnormality of aromatic amino acid family metabolism (HP:0004338)1.93863002
139Flat acetabular roof (HP:0003180)1.93650236
140Hypoplastic nipples (HP:0002557)1.93472800
141Alkalosis (HP:0001948)1.93263891
142Hyperphosphaturia (HP:0003109)1.92893066
143Blue irides (HP:0000635)1.92411305
144Urinary bladder sphincter dysfunction (HP:0002839)1.89106781
145Decreased circulating renin level (HP:0003351)1.88144375
146Sensory axonal neuropathy (HP:0003390)1.86219450
147Abnormal glucose tolerance (HP:0001952)1.85717565
148Torticollis (HP:0000473)1.85208244
149Mitral stenosis (HP:0001718)1.83945364
150Clumsiness (HP:0002312)1.82720444
151Lower limb asymmetry (HP:0100559)1.82416527
152Hypotension (HP:0002615)1.80937790
153Vascular tortuosity (HP:0004948)1.80779032
154EEG with generalized epileptiform discharges (HP:0011198)1.79626175
155Nausea (HP:0002018)1.78265697
156Irritability (HP:0000737)1.78009031
157Status epilepticus (HP:0002133)1.77923568
158Esotropia (HP:0000565)1.77450571
159Bradykinesia (HP:0002067)1.76836376
160Focal dystonia (HP:0004373)1.75420478
161Broad metatarsal (HP:0001783)1.75120860
162Delayed epiphyseal ossification (HP:0002663)1.75093507
163Rickets (HP:0002748)1.74295228
164Subcapsular cataract (HP:0000523)1.73281543
165Hyperglycinuria (HP:0003108)1.73132729
166Urinary urgency (HP:0000012)1.72897735
167Widely spaced teeth (HP:0000687)1.72065578
168Prolonged partial thromboplastin time (HP:0003645)1.71016213
169Arterial tortuosity (HP:0005116)1.69165019
170Upper limb amyotrophy (HP:0009129)1.69124689
171Distal upper limb amyotrophy (HP:0007149)1.69124689
172Protuberant abdomen (HP:0001538)1.68880581
173Double outlet right ventricle (HP:0001719)1.67034250
174Congenital malformation of the right heart (HP:0011723)1.67034250
175Hypsarrhythmia (HP:0002521)1.65999274
176Hypokalemia (HP:0002900)1.65482236
177Abnormality of salivation (HP:0100755)1.63971490
178Abnormality of alkaline phosphatase activity (HP:0004379)1.63646084
179Abnormal auditory evoked potentials (HP:0006958)1.62491151
180Retinal dysplasia (HP:0007973)1.62322520
181Aortic dissection (HP:0002647)1.62271733

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.66224177
2MST1R4.43294542
3ACVR1B3.81699786
4NTRK33.66057572
5TNIK3.55913518
6OXSR13.25806971
7MARK12.87942206
8CASK2.86911939
9RIPK12.84434009
10EPHA22.69961481
11MAP3K92.50608464
12FES2.48969643
13TYRO32.44957421
14WNK32.40199045
15MAP3K42.31224362
16STK392.27127070
17PRKG22.16084281
18WNK42.10853237
19PNCK2.07018042
20MET2.03649938
21LMTK22.03158279
22MAP3K121.99761660
23NEK11.99390677
24MINK11.98649762
25MAP2K71.98254188
26PDGFRA1.97196471
27AKT31.91626843
28ERN11.90208740
29EPHA31.84513725
30RIPK41.75774085
31PRPF4B1.70857481
32MAPK131.65822400
33DAPK21.49565104
34NTRK11.48553848
35NTRK21.46429547
36DDR21.43826827
37PAK61.35268526
38TESK11.33928056
39PLK21.29420899
40PRKCG1.28755124
41CDK51.27138942
42FGFR41.23318052
43MYLK1.23241206
44MAP2K41.23142032
45NME11.21883057
46KSR21.19902254
47PIK3CA1.17130839
48SGK2231.13680130
49SGK4941.13680130
50STK381.12979053
51EPHB21.11663890
52CDK191.11418309
53GRK51.08287785
54DAPK11.05900512
55CAMKK11.03690699
56CAMK2A1.02520511
57CAMK2B1.01553810
58ARAF0.97745116
59PINK10.95954721
60NEK60.95413137
61LATS10.94673528
62KSR10.93914841
63PDK20.93833532
64PTK20.93768667
65MAP3K20.91955697
66CAMKK20.89184849
67PKN10.89011918
68IRAK20.87361058
69PTK2B0.86484876
70SIK10.86154947
71PAK30.85552376
72STK38L0.84522860
73FGR0.84432748
74BMPR20.80381916
75MAP3K100.78808355
76UHMK10.75866402
77PRKD30.74641513
78SGK10.72153733
79MAP3K130.70822875
80ERBB30.69850411
81PRKCE0.68014279
82JAK10.65680109
83STK110.65471772
84PDPK10.65009006
85PRKACG0.63887926
86EPHB10.63498618
87CDK140.62022902
88ERBB20.61616388
89BCR0.61478302
90TSSK60.61459307
91PDK40.61011966
92PDK30.61011966
93CSNK1G20.59823871
94PDGFRB0.59622143
95TIE10.58790605
96SGK20.56892708
97CAMK10.55540049
98MARK20.55032040
99CAMK2D0.54787095
100CSNK1A1L0.54749654
101DYRK1A0.54530178
102CDK180.54349392
103CDK150.53441430
104SIK20.53415117
105PDK10.52784737
106FER0.51976452
107PHKG20.51210366
108PHKG10.51210366
109MAPKAPK50.51062969
110SRC0.49782013
111DAPK30.48143524
112RPS6KA20.47457505
113ROCK20.46026015
114RET0.45134391
115FYN0.44499951
116CDK11A0.44301818
117CSNK1G10.43680975
118PRKCZ0.43600292
119LIMK10.42824223
120CAMK2G0.42368284
121CDC42BPA0.42174203
122CSNK1G30.41254943
123NEK90.40592330
124CSNK1A10.39219703
125GRK70.39115455
126PRKACA0.38890105
127LATS20.38560935
128ERBB40.37980409
129RPS6KA30.37644110
130GRK10.36527421
131WNK10.35959633
132CAMK40.35904065
133PRKCH0.35050044
134RAF10.34369257
135PRKCA0.33702222
136ROCK10.33537131
137MAP2K10.31834599
138SGK30.31537484
139PRKCQ0.31204398
140TAOK10.30730467
141ICK0.29756868
142CSNK1E0.29122781
143CCNB10.25652222

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.86512203
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.08941749
3Caffeine metabolism_Homo sapiens_hsa002323.08719193
4Synaptic vesicle cycle_Homo sapiens_hsa047213.00366008
5Fat digestion and absorption_Homo sapiens_hsa049752.78085327
6Collecting duct acid secretion_Homo sapiens_hsa049662.78031334
7Renin-angiotensin system_Homo sapiens_hsa046142.70927643
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.58668782
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.54240600
10GABAergic synapse_Homo sapiens_hsa047272.50988323
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.46930916
12* Glutamatergic synapse_Homo sapiens_hsa047242.42114130
13Retinol metabolism_Homo sapiens_hsa008302.41983148
14Long-term potentiation_Homo sapiens_hsa047202.36875567
15Arginine biosynthesis_Homo sapiens_hsa002202.34181774
16Starch and sucrose metabolism_Homo sapiens_hsa005002.26253299
17Circadian entrainment_Homo sapiens_hsa047132.23449864
18Chemical carcinogenesis_Homo sapiens_hsa052042.20785660
19Histidine metabolism_Homo sapiens_hsa003402.19658203
20Morphine addiction_Homo sapiens_hsa050322.19635862
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.15755248
22Salivary secretion_Homo sapiens_hsa049702.13807004
23Amphetamine addiction_Homo sapiens_hsa050312.12163386
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.10835355
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.97055497
26Olfactory transduction_Homo sapiens_hsa047401.96957315
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.96390598
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.94552687
29* Protein digestion and absorption_Homo sapiens_hsa049741.91128778
30Gastric acid secretion_Homo sapiens_hsa049711.85697830
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.84566514
32Dopaminergic synapse_Homo sapiens_hsa047281.79140366
33Cholinergic synapse_Homo sapiens_hsa047251.73984721
34Long-term depression_Homo sapiens_hsa047301.70155804
35Phenylalanine metabolism_Homo sapiens_hsa003601.66102283
36Serotonergic synapse_Homo sapiens_hsa047261.64880009
37PPAR signaling pathway_Homo sapiens_hsa033201.64775296
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.61467011
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58586119
40Linoleic acid metabolism_Homo sapiens_hsa005911.56241807
41Vitamin B6 metabolism_Homo sapiens_hsa007501.54249501
42Taste transduction_Homo sapiens_hsa047421.52581070
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.48833569
44Renin secretion_Homo sapiens_hsa049241.48622829
45Axon guidance_Homo sapiens_hsa043601.47070093
46Insulin secretion_Homo sapiens_hsa049111.43696216
47Fatty acid degradation_Homo sapiens_hsa000711.42814574
48Oxytocin signaling pathway_Homo sapiens_hsa049211.41663645
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.38494755
50Calcium signaling pathway_Homo sapiens_hsa040201.36296296
51Butanoate metabolism_Homo sapiens_hsa006501.33521197
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.33083852
53Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32086423
54Vibrio cholerae infection_Homo sapiens_hsa051101.29613943
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27671222
56Arginine and proline metabolism_Homo sapiens_hsa003301.26808584
57Complement and coagulation cascades_Homo sapiens_hsa046101.26453995
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.25481733
59Tryptophan metabolism_Homo sapiens_hsa003801.25284491
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23288062
61Galactose metabolism_Homo sapiens_hsa000521.21258784
62Sulfur metabolism_Homo sapiens_hsa009201.20622580
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.18598458
64Fructose and mannose metabolism_Homo sapiens_hsa000511.14941409
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09918198
66Gap junction_Homo sapiens_hsa045401.09660053
67GnRH signaling pathway_Homo sapiens_hsa049121.09508351
68Tyrosine metabolism_Homo sapiens_hsa003501.09282246
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08162951
70Oxidative phosphorylation_Homo sapiens_hsa001901.07074259
71Cocaine addiction_Homo sapiens_hsa050301.06857076
72Choline metabolism in cancer_Homo sapiens_hsa052311.05431483
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00428437
74cAMP signaling pathway_Homo sapiens_hsa040240.99797754
75Phototransduction_Homo sapiens_hsa047440.96285794
76Mineral absorption_Homo sapiens_hsa049780.96083046
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.95540290
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95342530
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94919371
80Arachidonic acid metabolism_Homo sapiens_hsa005900.94878194
81Cardiac muscle contraction_Homo sapiens_hsa042600.94214668
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89787626
83Thyroid hormone synthesis_Homo sapiens_hsa049180.87425686
84Sphingolipid metabolism_Homo sapiens_hsa006000.86919345
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.83161573
86Pancreatic secretion_Homo sapiens_hsa049720.82304964
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.82200010
88Estrogen signaling pathway_Homo sapiens_hsa049150.81562164
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80571461
90Bile secretion_Homo sapiens_hsa049760.80236597
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78989560
92Alzheimers disease_Homo sapiens_hsa050100.78944037
93Glioma_Homo sapiens_hsa052140.78930366
94Type II diabetes mellitus_Homo sapiens_hsa049300.78664977
95Vitamin digestion and absorption_Homo sapiens_hsa049770.77304041
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70698002
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.70404831
98ErbB signaling pathway_Homo sapiens_hsa040120.69997267
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67228865
100Melanogenesis_Homo sapiens_hsa049160.66105563
1012-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65465022
102Fatty acid biosynthesis_Homo sapiens_hsa000610.65163955
103Ether lipid metabolism_Homo sapiens_hsa005650.63806239
104Peroxisome_Homo sapiens_hsa041460.63698214
105Rheumatoid arthritis_Homo sapiens_hsa053230.61424545
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.61211158
107Fatty acid metabolism_Homo sapiens_hsa012120.60611986
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60365360
109Oocyte meiosis_Homo sapiens_hsa041140.60294286
110Cyanoamino acid metabolism_Homo sapiens_hsa004600.58570165
111ABC transporters_Homo sapiens_hsa020100.53962687
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52397668
113Biosynthesis of amino acids_Homo sapiens_hsa012300.52355407
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50486453
115Ras signaling pathway_Homo sapiens_hsa040140.48458858
116beta-Alanine metabolism_Homo sapiens_hsa004100.47649510
117Glycerolipid metabolism_Homo sapiens_hsa005610.47090698
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46052340
119Parkinsons disease_Homo sapiens_hsa050120.45793358
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44908762
121Tight junction_Homo sapiens_hsa045300.44546818
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44455989
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44448369
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43764993
125Renal cell carcinoma_Homo sapiens_hsa052110.41660428
126Prion diseases_Homo sapiens_hsa050200.41273302
127Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39194205
128Inositol phosphate metabolism_Homo sapiens_hsa005620.36729314
129Pyruvate metabolism_Homo sapiens_hsa006200.34745146
130Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34656388
131VEGF signaling pathway_Homo sapiens_hsa043700.34550064
132Rap1 signaling pathway_Homo sapiens_hsa040150.34267969
133Regulation of autophagy_Homo sapiens_hsa041400.34031625
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33692177
135ECM-receptor interaction_Homo sapiens_hsa045120.33020288
136MAPK signaling pathway_Homo sapiens_hsa040100.32158833
137Steroid biosynthesis_Homo sapiens_hsa001000.31832403
138Dorso-ventral axis formation_Homo sapiens_hsa043200.31637112
139Huntingtons disease_Homo sapiens_hsa050160.31522888
140Circadian rhythm_Homo sapiens_hsa047100.30741245
141Glucagon signaling pathway_Homo sapiens_hsa049220.30635650
142Carbon metabolism_Homo sapiens_hsa012000.30184552
143AMPK signaling pathway_Homo sapiens_hsa041520.29011426
144Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28324509
145Ovarian steroidogenesis_Homo sapiens_hsa049130.25644477
146Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25593406
147Endocytosis_Homo sapiens_hsa041440.25380749
148Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25281908
149Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24951596
150Insulin resistance_Homo sapiens_hsa049310.24462050
151Propanoate metabolism_Homo sapiens_hsa006400.19442737
152Amoebiasis_Homo sapiens_hsa051460.18097060

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