SLC1A5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus (Larriba et al., 2001 [PubMed 11781704]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)5.63625533
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.37042547
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.37042547
4valine metabolic process (GO:0006573)5.26335499
5negative regulation of phagocytosis (GO:0050765)5.02509985
6proline biosynthetic process (GO:0006561)5.01330053
7positive regulation of gamma-delta T cell activation (GO:0046645)5.00909785
8Golgi transport vesicle coating (GO:0048200)4.73380153
9COPI coating of Golgi vesicle (GO:0048205)4.73380153
10antigen processing and presentation of endogenous antigen (GO:0019883)4.71495931
11pentose-phosphate shunt (GO:0006098)4.64325061
12white fat cell differentiation (GO:0050872)4.61683975
13regulation of gamma-delta T cell differentiation (GO:0045586)4.50105084
14mitotic chromosome condensation (GO:0007076)4.37842570
15nuclear pore complex assembly (GO:0051292)4.33295552
16triglyceride catabolic process (GO:0019433)4.26715662
17NADPH regeneration (GO:0006740)4.11620893
18regulation of sequestering of triglyceride (GO:0010889)4.08872821
19brown fat cell differentiation (GO:0050873)4.00121115
20regulation of gamma-delta T cell activation (GO:0046643)3.97451448
21DNA strand elongation involved in DNA replication (GO:0006271)3.87980211
22DNA strand elongation (GO:0022616)3.83036981
23positive regulation of histone deacetylation (GO:0031065)3.81889131
24protein complex localization (GO:0031503)3.77638880
25cellular protein complex localization (GO:0034629)3.72917486
26nuclear pore organization (GO:0006999)3.70232161
27ribosomal small subunit assembly (GO:0000028)3.65985740
28maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.62706376
29regulation of mammary gland epithelial cell proliferation (GO:0033599)3.58794700
30negative regulation of granulocyte differentiation (GO:0030853)3.58772181
31neutral lipid catabolic process (GO:0046461)3.57180585
32acylglycerol catabolic process (GO:0046464)3.57180585
33regulation of cholesterol storage (GO:0010885)3.55983445
34formation of translation preinitiation complex (GO:0001731)3.55867239
35DNA replication initiation (GO:0006270)3.55136705
36folic acid-containing compound biosynthetic process (GO:0009396)3.53655026
37L-serine metabolic process (GO:0006563)3.53246967
38protein retention in ER lumen (GO:0006621)3.46139618
39biotin metabolic process (GO:0006768)3.42757196
40lipid particle organization (GO:0034389)3.39108305
41heterochromatin organization (GO:0070828)3.34105229
42positive regulation of B cell differentiation (GO:0045579)3.32425294
43mitotic sister chromatid segregation (GO:0000070)3.31826996
44tyrosine phosphorylation of STAT protein (GO:0007260)3.29920138
45lipid storage (GO:0019915)3.29777904
46regulation of translational termination (GO:0006449)3.27093691
47telomere maintenance via semi-conservative replication (GO:0032201)3.25884348
48protein localization to chromosome, centromeric region (GO:0071459)3.24783894
49positive thymic T cell selection (GO:0045059)3.20480724
50viral transcription (GO:0019083)3.19013662
51regulation of interleukin-12 biosynthetic process (GO:0045075)3.18727832
52antigen processing and presentation via MHC class Ib (GO:0002475)3.18595370
53antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.17811013
54positive regulation of protein deacetylation (GO:0090312)3.17056942
55proline metabolic process (GO:0006560)3.15669148
56peptidyl-arginine omega-N-methylation (GO:0035247)3.15315001
57desmosome organization (GO:0002934)3.14932486
58planar cell polarity pathway involved in neural tube closure (GO:0090179)3.13301198
59glucose catabolic process (GO:0006007)3.11048555
60mitotic nuclear envelope disassembly (GO:0007077)3.10833476
61pore complex assembly (GO:0046931)3.07816137
62translational termination (GO:0006415)3.05907746
63positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.01264102
64spliceosomal tri-snRNP complex assembly (GO:0000244)2.98322553
65sister chromatid segregation (GO:0000819)2.98023952
66cell-substrate adherens junction assembly (GO:0007045)2.97784253
67focal adhesion assembly (GO:0048041)2.97784253
68adherens junction assembly (GO:0034333)2.96457944
69establishment of integrated proviral latency (GO:0075713)2.93740681
70nucleobase-containing small molecule interconversion (GO:0015949)2.93432155
71negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.91256467
72nuclear envelope disassembly (GO:0051081)2.91239539
73membrane disassembly (GO:0030397)2.91239539
74regulation of RNA export from nucleus (GO:0046831)2.88441336
75protein localization to kinetochore (GO:0034501)2.88203764
76retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.87613940
77hemidesmosome assembly (GO:0031581)2.87205446
78adaptation of signaling pathway (GO:0023058)2.85745904
79triglyceride biosynthetic process (GO:0019432)2.85226994
80regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.83367277
81negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.82864648
82cellular response to zinc ion (GO:0071294)2.82517900
83activation of Rac GTPase activity (GO:0032863)2.81552972
84cell-substrate junction assembly (GO:0007044)2.80851720
85negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.79387939
86cellular response to lithium ion (GO:0071285)2.78554756
87DNA duplex unwinding (GO:0032508)2.78520267
88chromosome condensation (GO:0030261)2.77092975
89oxaloacetate metabolic process (GO:0006107)2.76112522
90tRNA aminoacylation for protein translation (GO:0006418)2.74460594
91nuclear envelope reassembly (GO:0031468)2.74431905
92mitotic nuclear envelope reassembly (GO:0007084)2.74431905
93histone arginine methylation (GO:0034969)2.73881554
94protein maturation by protein folding (GO:0022417)2.73081971
95translational elongation (GO:0006414)2.72932466
96DNA topological change (GO:0006265)2.71715854
97fatty acid transmembrane transport (GO:1902001)2.71146755
98regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.70435884
99protein export from nucleus (GO:0006611)2.69988856
100mitotic metaphase plate congression (GO:0007080)2.69596054
101negative regulation of protein autophosphorylation (GO:0031953)2.69594679
102regulation of B cell differentiation (GO:0045577)2.68971916
103ribosome assembly (GO:0042255)2.68446278
104negative thymic T cell selection (GO:0045060)2.68044645
105mitochondrial DNA metabolic process (GO:0032042)2.67874062
106protoporphyrinogen IX metabolic process (GO:0046501)2.67702911
107tetrahydrofolate metabolic process (GO:0046653)2.67357394
108positive regulation of nuclease activity (GO:0032075)2.67046071
109establishment of apical/basal cell polarity (GO:0035089)2.66129484
110JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.66097725
111mRNA stabilization (GO:0048255)2.66024043
112RNA stabilization (GO:0043489)2.66024043
113DNA replication checkpoint (GO:0000076)2.65971234
114folic acid metabolic process (GO:0046655)2.64646500
115activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.64625471
116apoptotic process involved in morphogenesis (GO:0060561)2.64579250
117maternal placenta development (GO:0001893)2.64423262
118B cell receptor signaling pathway (GO:0050853)2.64294299
119growth hormone receptor signaling pathway (GO:0060396)2.64162839
120ribosome biogenesis (GO:0042254)2.63912406
121positive regulation of DNA-dependent DNA replication (GO:2000105)2.63812479
122glucose 6-phosphate metabolic process (GO:0051156)2.63460818
123neutral lipid biosynthetic process (GO:0046460)2.63100487
124acylglycerol biosynthetic process (GO:0046463)2.63100487
125coenzyme A biosynthetic process (GO:0015937)2.62801700
126amino acid activation (GO:0043038)2.60356052
127tRNA aminoacylation (GO:0043039)2.60356052
128DNA geometric change (GO:0032392)2.59945617
129negative T cell selection (GO:0043383)2.59006752
130tricarboxylic acid metabolic process (GO:0072350)2.58892207
131regulation of translational elongation (GO:0006448)2.58890954
132regulation of sister chromatid cohesion (GO:0007063)2.57371621
133negative regulation of interleukin-12 production (GO:0032695)2.57362194
134telomere maintenance via recombination (GO:0000722)2.56880943
135endoplasmic reticulum unfolded protein response (GO:0030968)2.56878630
136nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.56818046
137branching involved in mammary gland duct morphogenesis (GO:0060444)2.55451655
138negative regulation of erythrocyte differentiation (GO:0045647)2.55051333
139positive regulation of fatty acid beta-oxidation (GO:0032000)2.54499846
140mitotic sister chromatid cohesion (GO:0007064)2.54076491
141DNA unwinding involved in DNA replication (GO:0006268)2.53564689
142SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.53122653
143nuclear envelope organization (GO:0006998)2.52979190
144regulation of macrophage derived foam cell differentiation (GO:0010743)2.52947869
145regulation of fatty acid beta-oxidation (GO:0031998)2.52037582
146regulation of granulocyte differentiation (GO:0030852)2.51090768
147natural killer cell differentiation (GO:0001779)2.50716033
148regulation of response to interferon-gamma (GO:0060330)2.50683557
149protein heterotrimerization (GO:0070208)2.49930037
150DNA conformation change (GO:0071103)2.49691102
151positive regulation of lipid storage (GO:0010884)2.49664296
152regulation of nucleobase-containing compound transport (GO:0032239)2.49576968
153maturation of SSU-rRNA (GO:0030490)2.49470429
154negative regulation of stress fiber assembly (GO:0051497)2.49254582
155peptidyl-arginine methylation (GO:0018216)2.49248625
156peptidyl-arginine N-methylation (GO:0035246)2.49248625
157regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.48435528
158response to interleukin-15 (GO:0070672)2.46878744
159protein-DNA complex disassembly (GO:0032986)2.46741329
160nucleosome disassembly (GO:0006337)2.46741329
161branched-chain amino acid metabolic process (GO:0009081)2.46636265
162epithelial cell-cell adhesion (GO:0090136)2.46465763
163ER-nucleus signaling pathway (GO:0006984)2.46161690
164serine family amino acid biosynthetic process (GO:0009070)2.45392144
165protein targeting to ER (GO:0045047)2.45185185
166regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.44404260
167positive regulation of natural killer cell differentiation (GO:0032825)2.43832600
168thymic T cell selection (GO:0045061)2.43694320
169positive regulation of fatty acid oxidation (GO:0046321)2.43294498
170carnitine shuttle (GO:0006853)2.42915497
171ribosomal small subunit biogenesis (GO:0042274)2.42493782
172cotranslational protein targeting to membrane (GO:0006613)2.41660310
173translational initiation (GO:0006413)2.40580284
174mucosal-associated lymphoid tissue development (GO:0048537)2.39132643
175Peyers patch development (GO:0048541)2.39132643
176cellular response to growth hormone stimulus (GO:0071378)2.35370700
177establishment of protein localization to endoplasmic reticulum (GO:0072599)2.33019465
178viral life cycle (GO:0019058)2.31965364
179T cell homeostasis (GO:0043029)2.31842449
180regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.29537349
181regulation of B cell receptor signaling pathway (GO:0050855)2.29459051
182protein localization to endoplasmic reticulum (GO:0070972)2.26853025
183positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.26060662
184ovulation from ovarian follicle (GO:0001542)2.26038605
185positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.25332381
186negative regulation of lipid storage (GO:0010888)2.24850695
187regulation of fatty acid oxidation (GO:0046320)2.24461064
188positive regulation of cellular response to insulin stimulus (GO:1900078)2.24095820
189cellular protein complex disassembly (GO:0043624)2.22638708
190cellular response to interleukin-4 (GO:0071353)2.22558659
191regulation of translational fidelity (GO:0006450)2.21779545
192T cell selection (GO:0045058)2.20911130
193fatty acid homeostasis (GO:0055089)2.20506804

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.64338788
2* E2F7_22180533_ChIP-Seq_HELA_Human5.29388483
3* MYC_22102868_ChIP-Seq_BL_Human3.26010963
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.97596265
5VDR_21846776_ChIP-Seq_THP-1_Human2.74493720
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.73737142
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.60052040
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54006541
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.46752440
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.30881321
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.29611215
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.25995142
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.22113129
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.11464562
15CLOCK_20551151_ChIP-Seq_293T_Human2.08909004
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.08518260
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.08102915
18GATA1_22025678_ChIP-Seq_K562_Human2.00262333
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96524928
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.93555473
21MYB_21317192_ChIP-Seq_ERMYB_Mouse1.93314533
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.91913708
23* MAF_26560356_Chip-Seq_TH1_Human1.91597284
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.90943330
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88365930
26MYB_26560356_Chip-Seq_TH2_Human1.81414868
27CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.79905008
28SCL_19346495_ChIP-Seq_HPC-7_Human1.78384598
29* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77628443
30* UTX_26944678_Chip-Seq_JUKART_Human1.76986377
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.76375916
32* VDR_24763502_ChIP-Seq_THP-1_Human1.75073624
33* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.71831197
34MYB_26560356_Chip-Seq_TH1_Human1.69098960
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.67890791
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.67502658
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.64578479
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.61705832
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.60792130
40CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.58970045
41TCF7_22412390_ChIP-Seq_EML_Mouse1.58308277
42* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.57060631
43CIITA_25753668_ChIP-Seq_RAJI_Human1.55288469
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.54379705
45RUNX_20019798_ChIP-Seq_JUKART_Human1.54321707
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.53296998
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.53039124
48* ELK3_25401928_ChIP-Seq_HUVEC_Human1.52660628
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52329043
50STAT4_19710469_ChIP-ChIP_TH1__Mouse1.50932747
51* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50137375
52JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.48385371
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.47603956
54* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.45257625
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45241940
56* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.45194819
57NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44883030
58* SPI1_23547873_ChIP-Seq_NB4_Human1.44719400
59MAF_26560356_Chip-Seq_TH2_Human1.43535944
60* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43252203
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42806470
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.40223275
63CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.39889575
64HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.39054064
65FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.37190939
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36323612
67MYC_18358816_ChIP-ChIP_MESCs_Mouse1.35263251
68ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34408623
69IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.34208664
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.33388151
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32953177
72TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.32216134
73TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.32057530
74* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31635305
75KDM2B_26808549_Chip-Seq_DND41_Human1.31599015
76IRF8_21731497_ChIP-ChIP_J774_Mouse1.30160493
77CREB1_15753290_ChIP-ChIP_HEK293T_Human1.30106485
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.29032331
79* XRN2_22483619_ChIP-Seq_HELA_Human1.28126862
80TP63_17297297_ChIP-ChIP_HaCaT_Human1.27161480
81GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24790735
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.24250849
83STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.23486680
84SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22925128
85* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.22855129
86* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22328973
87PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20492646
88TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20307255
89* TTF2_22483619_ChIP-Seq_HELA_Human1.20289327
90GABP_19822575_ChIP-Seq_HepG2_Human1.19816802
91* E2F1_21310950_ChIP-Seq_MCF-7_Human1.19793578
92KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19498646
93P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19411656
94VDR_23849224_ChIP-Seq_CD4+_Human1.18910540
95STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17361126
96* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17234999
97* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.15829811
98FOXP3_21729870_ChIP-Seq_TREG_Human1.15075841
99GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13979189
100SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13698328
101ZNF263_19887448_ChIP-Seq_K562_Human1.13649789
102AR_21909140_ChIP-Seq_LNCAP_Human1.12475187
103SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.11168531
104HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09511675
105MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09198877
106UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09127864
107SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07941472
108* CHD1_26751641_Chip-Seq_LNCaP_Human1.06952548
109ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06038936
110PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05784762
111TET1_21451524_ChIP-Seq_MESCs_Mouse1.05528066
112HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05179104
113IRF8_27001747_Chip-Seq_BMDM_Mouse1.04622904
114ETS1_20019798_ChIP-Seq_JURKAT_Human1.04145314
115DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03280009
116SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01333860
117* NCOR1_26117541_ChIP-Seq_K562_Human1.00221721
118* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00205410
119* SPI1_23127762_ChIP-Seq_K562_Human0.99217864
120KDM5A_27292631_Chip-Seq_BREAST_Human0.99005847
121KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98592149
122NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.96934700
123ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96806074
124* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96633610
125TFEB_21752829_ChIP-Seq_HELA_Human0.96586608
126* GATA3_27048872_Chip-Seq_THYMUS_Human0.96505130
127CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.95226236
128KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.93586020
129RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93385231
130TP53_22127205_ChIP-Seq_IMR90_Human0.93374415
131CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93247981
132ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92841850
133ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92545590
134* ATF3_27146783_Chip-Seq_COLON_Human0.92344665
135YY1_21170310_ChIP-Seq_MESCs_Mouse0.92336692
136UBF1/2_26484160_Chip-Seq_HMECs_Human0.91843110
137* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91648972
138NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.91540626
139TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91038652
140* DCP1A_22483619_ChIP-Seq_HELA_Human0.90652722
141* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90504240
142* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90266995
143DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90022045
144MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88340210
145* LXR_22292898_ChIP-Seq_THP-1_Human0.87491158
146ELF1_20517297_ChIP-Seq_JURKAT_Human0.86671743
147STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85668916
148FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.84537151
149RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83822238
150RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.83686235
151RACK7_27058665_Chip-Seq_MCF-7_Human0.83639945

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose4.67345709
2MP0005666_abnormal_adipose_tissue3.32714868
3MP0004185_abnormal_adipocyte_glucose3.09973064
4MP0002166_altered_tumor_susceptibility2.88478722
5MP0004130_abnormal_muscle_cell2.68109349
6MP0010234_abnormal_vibrissa_follicle2.62733350
7MP0008438_abnormal_cutaneous_collagen2.58645642
8MP0002396_abnormal_hematopoietic_system2.56007488
9MP0005375_adipose_tissue_phenotype2.50546863
10MP0000685_abnormal_immune_system2.47335798
11MP0004272_abnormal_basement_membrane2.33887409
12MP0002877_abnormal_melanocyte_morpholog2.32815877
13MP0001835_abnormal_antigen_presentation2.27540826
14MP0003763_abnormal_thymus_physiology2.19906701
15MP0002006_tumorigenesis2.19587300
16MP0002796_impaired_skin_barrier2.05173784
17MP0003941_abnormal_skin_development1.99137595
18MP0008932_abnormal_embryonic_tissue1.98319966
19MP0001800_abnormal_humoral_immune1.96578014
20MP0003300_gastrointestinal_ulcer1.96125319
21MP0003436_decreased_susceptibility_to1.96021641
22MP0005451_abnormal_body_composition1.93576290
23MP0005501_abnormal_skin_physiology1.91311038
24MP0001849_ear_inflammation1.87582706
25MP0001730_embryonic_growth_arrest1.86425747
26MP0003724_increased_susceptibility_to1.85631147
27MP0009115_abnormal_fat_cell1.81112568
28MP0004233_abnormal_muscle_weight1.80763289
29MP0005387_immune_system_phenotype1.78669453
30MP0001790_abnormal_immune_system1.78669453
31MP0005257_abnormal_intraocular_pressure1.78387045
32MP0003191_abnormal_cellular_cholesterol1.76362080
33MP0005671_abnormal_response_to1.72579888
34MP0002971_abnormal_brown_adipose1.72508305
35MP0000003_abnormal_adipose_tissue1.71894335
36MP0002398_abnormal_bone_marrow1.71502126
37MP0000537_abnormal_urethra_morphology1.70085254
38MP0002970_abnormal_white_adipose1.67385276
39MP0004264_abnormal_extraembryonic_tissu1.67229933
40MP0003705_abnormal_hypodermis_morpholog1.65439251
41MP0010030_abnormal_orbit_morphology1.63966601
42MP0010352_gastrointestinal_tract_polyps1.63541896
43MP0005275_abnormal_skin_tensile1.63034921
44MP0001545_abnormal_hematopoietic_system1.61876975
45MP0005397_hematopoietic_system_phenotyp1.61876975
46MP0002254_reproductive_system_inflammat1.61266572
47MP0002452_abnormal_antigen_presenting1.61109755
48MP0002420_abnormal_adaptive_immunity1.56695763
49MP0003453_abnormal_keratinocyte_physiol1.53681948
50MP0001819_abnormal_immune_cell1.53675941
51MP0009672_abnormal_birth_weight1.52324393
52MP0009785_altered_susceptibility_to1.51331511
53MP0003303_peritoneal_inflammation1.51146030
54MP0005000_abnormal_immune_tolerance1.51117284
55MP0000689_abnormal_spleen_morphology1.48633765
56MP0004808_abnormal_hematopoietic_stem1.46548327
57MP0002723_abnormal_immune_serum1.45458254
58MP0005334_abnormal_fat_pad1.45175704
59MP0001672_abnormal_embryogenesis/_devel1.43759047
60MP0005380_embryogenesis_phenotype1.43759047
61MP0001853_heart_inflammation1.43264765
62MP0002080_prenatal_lethality1.42839066
63MP0005025_abnormal_response_to1.42759477
64MP0002405_respiratory_system_inflammati1.42035802
65MP0004858_abnormal_nervous_system1.41342800
66MP0002722_abnormal_immune_system1.41307142
67MP0000716_abnormal_immune_system1.39652577
68MP0000566_synostosis1.38739325
69MP0000013_abnormal_adipose_tissue1.37114123
70MP0000678_abnormal_parathyroid_gland1.36892892
71MP0010155_abnormal_intestine_physiology1.36751586
72MP0003984_embryonic_growth_retardation1.36618200
73MP0003566_abnormal_cell_adhesion1.35808062
74MP0001873_stomach_inflammation1.35741318
75MP0006054_spinal_hemorrhage1.33578809
76MP0008007_abnormal_cellular_replicative1.33155624
77MP0002088_abnormal_embryonic_growth/wei1.29883913
78MP0001697_abnormal_embryo_size1.29627963
79MP0002429_abnormal_blood_cell1.28239843
80MP0002098_abnormal_vibrissa_morphology1.26198088
81MP0002086_abnormal_extraembryonic_tissu1.26045251
82MP0000579_abnormal_nail_morphology1.25437967
83MP0000490_abnormal_crypts_of1.24193617
84MP0000703_abnormal_thymus_morphology1.23742313
85MP0002085_abnormal_embryonic_tissue1.22792848
86MP0003693_abnormal_embryo_hatching1.22526564
87MP0009333_abnormal_splenocyte_physiolog1.21527049
88MP0004782_abnormal_surfactant_physiolog1.20671292
89MP0000858_altered_metastatic_potential1.20110944
90MP0003959_abnormal_lean_body1.20077365
91MP0003866_abnormal_defecation1.19784491
92MP0000467_abnormal_esophagus_morphology1.19460089
93MP0005623_abnormal_meninges_morphology1.18860505
94MP0001216_abnormal_epidermal_layer1.18081819
95MP0010329_abnormal_lipoprotein_level1.17532839
96MP0000762_abnormal_tongue_morphology1.17154193
97MP0005076_abnormal_cell_differentiation1.16395898
98MP0002933_joint_inflammation1.14865088
99MP0001661_extended_life_span1.14303193
100MP0003942_abnormal_urinary_system1.13820991
101MP0008260_abnormal_autophagy1.11453110
102MP0002419_abnormal_innate_immunity1.10179979
103MP0003828_pulmonary_edema1.09891568
104MP0001533_abnormal_skeleton_physiology1.09195637
105MP0005621_abnormal_cell_physiology1.08196745
106MP0002019_abnormal_tumor_incidence1.07537403
107MP0009278_abnormal_bone_marrow1.05678827
108MP0000313_abnormal_cell_death1.05042739
109MP0002084_abnormal_developmental_patter1.04843711
110MP0005464_abnormal_platelet_physiology1.04049946
111MP0000609_abnormal_liver_physiology1.03646301
112MP0009053_abnormal_anal_canal1.03423036
113MP0003186_abnormal_redox_activity1.02365636
114MP0001845_abnormal_inflammatory_respons1.01874698
115MP0010307_abnormal_tumor_latency1.01623904
116MP0002060_abnormal_skin_morphology1.00109779
117MP0009931_abnormal_skin_appearance1.00092182
118MP0002249_abnormal_larynx_morphology0.99758877
119MP0004197_abnormal_fetal_growth/weight/0.98800478
120MP0008961_abnormal_basal_metabolism0.96457224
121MP0010771_integument_phenotype0.96157112
122MP0003077_abnormal_cell_cycle0.96028540
123MP0000465_gastrointestinal_hemorrhage0.95900607
124MP0008058_abnormal_DNA_repair0.95875141
125MP0003448_altered_tumor_morphology0.95779240
126MP0003315_abnormal_perineum_morphology0.95522957
127MP0000377_abnormal_hair_follicle0.95508385
128MP0000627_abnormal_mammary_gland0.95366582
129MP0002876_abnormal_thyroid_physiology0.94937377
130MP0010094_abnormal_chromosome_stability0.94878339
131MP0005503_abnormal_tendon_morphology0.94803373
132MP0003115_abnormal_respiratory_system0.94401786
133MP0003656_abnormal_erythrocyte_physiolo0.94321689
134MP0001881_abnormal_mammary_gland0.94044014
135MP0003786_premature_aging0.93589918
136MP0004957_abnormal_blastocyst_morpholog0.93402764
137MP0002089_abnormal_postnatal_growth/wei0.92970699
138MP0004947_skin_inflammation0.92860277
139MP0000343_altered_response_to0.92154465
140MP0003111_abnormal_nucleus_morphology0.91667154
141MP0001243_abnormal_dermal_layer0.89672335
142MP0005058_abnormal_lysosome_morphology0.89294489
143MP0005083_abnormal_biliary_tract0.88657794
144MP0002111_abnormal_tail_morphology0.88301556
145MP0005384_cellular_phenotype0.86402648
146MP0005508_abnormal_skeleton_morphology0.86247641
147MP0002697_abnormal_eye_size0.84498876
148MP0000428_abnormal_craniofacial_morphol0.83741942
149MP0001348_abnormal_lacrimal_gland0.83718573
150MP0005023_abnormal_wound_healing0.83468689
151MP0009384_cardiac_valve_regurgitation0.82971152
152MP0000534_abnormal_ureter_morphology0.82763142
153MP0003385_abnormal_body_wall0.79489577
154MP0005452_abnormal_adipose_tissue0.78980889
155MP0002118_abnormal_lipid_homeostasis0.78728359
156MP0002009_preneoplasia0.75700725
157MP0003091_abnormal_cell_migration0.74433599
158MP0009840_abnormal_foam_cell0.74159163
159MP0001915_intracranial_hemorrhage0.73776306
160MP0000432_abnormal_head_morphology0.73730468
161MP0001879_abnormal_lymphatic_vessel0.73551436
162MP0002148_abnormal_hypersensitivity_rea0.72453078
163MP0002132_abnormal_respiratory_system0.72363990
164MP0000733_abnormal_muscle_development0.72341209
165MP0008469_abnormal_protein_level0.71165443
166MP0001958_emphysema0.69426259
167MP0000350_abnormal_cell_proliferation0.68763123
168MP0000249_abnormal_blood_vessel0.68413400
169MP0000750_abnormal_muscle_regeneration0.67701476
170MP0009763_increased_sensitivity_to0.66823912
171MP0000477_abnormal_intestine_morphology0.66728045
172MP0001727_abnormal_embryo_implantation0.66382613
173MP0008057_abnormal_DNA_replication0.65530319

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.42874225
2Hypertriglyceridemia (HP:0002155)4.01984130
3Oligomenorrhea (HP:0000876)3.88081579
4Agammaglobulinemia (HP:0004432)3.84208423
5Recurrent bronchitis (HP:0002837)3.78948893
6Protrusio acetabuli (HP:0003179)3.65485586
7Acanthosis nigricans (HP:0000956)3.64554575
8T lymphocytopenia (HP:0005403)3.54528755
9Cellulitis (HP:0100658)3.47485485
10Abnormality of T cell number (HP:0011839)3.36550527
11Verrucae (HP:0200043)3.36508958
12Papilloma (HP:0012740)3.36508958
13B lymphocytopenia (HP:0010976)3.33574224
14Abnormality of B cell number (HP:0010975)3.33574224
15Combined immunodeficiency (HP:0005387)3.27577599
16Thrombocytosis (HP:0001894)3.24900597
17IgM deficiency (HP:0002850)3.24431371
18Recurrent viral infections (HP:0004429)3.24033898
19Chronic otitis media (HP:0000389)3.18159281
20Panhypogammaglobulinemia (HP:0003139)3.14273260
21Abnormality of T cells (HP:0002843)3.05546026
22Multiple enchondromatosis (HP:0005701)3.03478381
23Autoimmune thrombocytopenia (HP:0001973)2.97618800
24Selective tooth agenesis (HP:0001592)2.95323646
25Insomnia (HP:0100785)2.94634449
26Abnormality of the nasal mucosa (HP:0000433)2.89749816
27Nasal polyposis (HP:0100582)2.87887975
28Elevated erythrocyte sedimentation rate (HP:0003565)2.85783147
29Reduced subcutaneous adipose tissue (HP:0003758)2.85449982
30Severe combined immunodeficiency (HP:0004430)2.79432438
31Trismus (HP:0000211)2.77735873
32Gastrointestinal inflammation (HP:0004386)2.75995275
33Inflammation of the large intestine (HP:0002037)2.75062293
34Recurrent fungal infections (HP:0002841)2.74248864
35Colitis (HP:0002583)2.72369971
36Abnormality of T cell physiology (HP:0011840)2.63065976
37Aortic aneurysm (HP:0004942)2.62503940
38Vertebral compression fractures (HP:0002953)2.61929749
39Fragile skin (HP:0001030)2.61722958
40Abnormality of the umbilical cord (HP:0010881)2.60256487
41IgA deficiency (HP:0002720)2.51627791
42Abnormal gallbladder physiology (HP:0012438)2.49758754
43Cholecystitis (HP:0001082)2.49758754
44Eczematoid dermatitis (HP:0000976)2.49499732
45Abnormality of cells of the erythroid lineage (HP:0012130)2.49024590
46Reticulocytosis (HP:0001923)2.47197437
47Abnormality of the fingertips (HP:0001211)2.43661842
48Premature skin wrinkling (HP:0100678)2.43661491
49Achilles tendon contracture (HP:0001771)2.42501782
50Septate vagina (HP:0001153)2.42058337
51Abnormal delayed hypersensitivity skin test (HP:0002963)2.40579534
52Ankle contracture (HP:0006466)2.39804302
53Chromosomal breakage induced by crosslinking agents (HP:0003221)2.38758690
54Distal upper limb amyotrophy (HP:0007149)2.37527171
55Upper limb amyotrophy (HP:0009129)2.37527171
56Abnormal number of erythroid precursors (HP:0012131)2.37107773
57Osteomyelitis (HP:0002754)2.36909665
58Cerebral aneurysm (HP:0004944)2.35618867
59Meningitis (HP:0001287)2.33151475
60Disproportionate tall stature (HP:0001519)2.32494671
61Increased density of long bones (HP:0006392)2.29453091
62Deviation of the thumb (HP:0009603)2.24752689
63Prolonged bleeding time (HP:0003010)2.22876056
64Long palpebral fissure (HP:0000637)2.21804589
65Hematochezia (HP:0002573)2.21700531
66Progressive muscle weakness (HP:0003323)2.21183229
67IgG deficiency (HP:0004315)2.21017899
68Abnormality of subcutaneous fat tissue (HP:0001001)2.20425285
69Ankyloglossia (HP:0010296)2.19379412
70Rectal prolapse (HP:0002035)2.19123393
71Increased connective tissue (HP:0009025)2.18031047
72Chromsome breakage (HP:0040012)2.17407073
73Thyroiditis (HP:0100646)2.16969513
74Nonimmune hydrops fetalis (HP:0001790)2.16696040
75Shallow orbits (HP:0000586)2.16598252
76Hyperglycinuria (HP:0003108)2.15852754
77Fatigue (HP:0012378)2.15640962
78Chronic sinusitis (HP:0011109)2.15592252
79Spinal rigidity (HP:0003306)2.15526257
80Abnormality of the distal phalanges of the toes (HP:0010182)2.15274937
81Bladder diverticulum (HP:0000015)2.15090517
82Short nail (HP:0001799)2.14300669
83Biconcave vertebral bodies (HP:0004586)2.13680165
84Long foot (HP:0001833)2.13552504
85Abnormality of the fetal cardiovascular system (HP:0010948)2.12738939
86Abnormal umbilical cord blood vessels (HP:0011403)2.12738939
87Single umbilical artery (HP:0001195)2.12738939
88Myocardial infarction (HP:0001658)2.12683270
89Insulin resistance (HP:0000855)2.12538825
90Elbow flexion contracture (HP:0002987)2.12168966
91Abnormality of cells of the lymphoid lineage (HP:0012140)2.10999534
92Abnormality of oral frenula (HP:0000190)2.10758817
93Emphysema (HP:0002097)2.10528647
94Atrophic scars (HP:0001075)2.10520738
95Lymphopenia (HP:0001888)2.10405336
96Proximal placement of thumb (HP:0009623)2.10354977
97Pustule (HP:0200039)2.09920764
98Reticulocytopenia (HP:0001896)2.09539249
99Ulnar bowing (HP:0003031)2.09246741
100Broad face (HP:0000283)2.08955404
101Increased nuchal translucency (HP:0010880)2.08915363
102Abnormality of reticulocytes (HP:0004312)2.08643222
103Abnormality of the Achilles tendon (HP:0005109)2.08206765
104Asymmetry of the thorax (HP:0001555)2.07781421
105Recurrent sinusitis (HP:0011108)2.07689215
106Gastrointestinal stroma tumor (HP:0100723)2.07117274
107Rhabdomyolysis (HP:0003201)2.06327654
108Distal lower limb amyotrophy (HP:0008944)2.05065656
109Myositis (HP:0100614)2.03742789
110Microglossia (HP:0000171)2.03475493
111Abnormal platelet volume (HP:0011876)2.03280438
112Growth hormone excess (HP:0000845)2.02519694
113Pterygium (HP:0001059)2.02408507
114Hypoplasia of the thymus (HP:0000778)2.02212578
115Breast hypoplasia (HP:0003187)2.01129897
116Breech presentation (HP:0001623)2.00722737
117High pitched voice (HP:0001620)1.99845750
118Upper limb muscle weakness (HP:0003484)1.99732510
119Large hands (HP:0001176)1.99075186
120Difficulty running (HP:0009046)1.98971776
121Spontaneous hematomas (HP:0007420)1.97848878
122Bronchitis (HP:0012387)1.96109183
123Hand muscle atrophy (HP:0009130)1.95865261
124Natal tooth (HP:0000695)1.93978541
125Myoglobinuria (HP:0002913)1.93120145
126Renal duplication (HP:0000075)1.92899919
127Wormian bones (HP:0002645)1.92707640
128Cervical subluxation (HP:0003308)1.92352041
129Rough bone trabeculation (HP:0100670)1.91928939
130Advanced eruption of teeth (HP:0006288)1.91602778
131Blue sclerae (HP:0000592)1.91203391
132Facial diplegia (HP:0001349)1.91168316
133Abnormality of dentin (HP:0010299)1.89866318
134Patellar dislocation (HP:0002999)1.88372753
135Interstitial pulmonary disease (HP:0006530)1.87727991
136Lymphoma (HP:0002665)1.87708087
137Recurrent cutaneous fungal infections (HP:0011370)1.87340672
138Chronic mucocutaneous candidiasis (HP:0002728)1.87340672
139Abnormalities of placenta or umbilical cord (HP:0001194)1.86960996
140Generalized amyotrophy (HP:0003700)1.86767544
141Pili torti (HP:0003777)1.86405633
142Aortic dissection (HP:0002647)1.86374326
143Overriding aorta (HP:0002623)1.85538109
144Back pain (HP:0003418)1.84860971
145Mildly elevated creatine phosphokinase (HP:0008180)1.84383645
146Osteolytic defects of the phalanges of the hand (HP:0009771)1.83309482
147Osteolytic defects of the hand bones (HP:0009699)1.83309482
148Basal cell carcinoma (HP:0002671)1.81784209
149Aplastic anemia (HP:0001915)1.78984367
150Slender build (HP:0001533)1.78033000
151Ridged nail (HP:0001807)1.77045743
152Increased muscle lipid content (HP:0009058)1.76159505
153Increased mean platelet volume (HP:0011877)1.75735218
154Increased IgE level (HP:0003212)1.75608107
155Skin ulcer (HP:0200042)1.73574239
156Decreased subcutaneous fat (HP:0001002)1.73394953
157Granulocytopenia (HP:0001913)1.73347328
158Sparse lateral eyebrow (HP:0005338)1.73331959
159Entropion (HP:0000621)1.73173471
160Elfin facies (HP:0004428)1.73104040
161Aplasia/Hypoplasia of the sacrum (HP:0008517)1.72151368
162Recurrent abscess formation (HP:0002722)1.71313108
163Sepsis (HP:0100806)1.71022809
164Polycythemia (HP:0001901)1.70674832
165Recurrent lower respiratory tract infections (HP:0002783)1.68546666
166Flat acetabular roof (HP:0003180)1.68500221
167Acute myeloid leukemia (HP:0004808)1.67901647
168Abnormality of the lumbar spine (HP:0100712)1.67846681
169Genu recurvatum (HP:0002816)1.67413940
170Abnormality of the acetabulum (HP:0003170)1.67121891
171Hyperacusis (HP:0010780)1.66600483
172Abnormality of the distal phalanx of the thumb (HP:0009617)1.65690838
173Broad distal phalanx of finger (HP:0009836)1.65684094
174Diaphragmatic weakness (HP:0009113)1.65181331
175Squamous cell carcinoma (HP:0002860)1.64716476
176Skin rash (HP:0000988)1.64295803
177Abnormality of carpal bone ossification (HP:0006257)1.63407770
178Spinal cord compression (HP:0002176)1.63362144
179Abnormal ossification of hand bones (HP:0005921)1.61591342
180Arnold-Chiari malformation (HP:0002308)1.61450838
181Syringomyelia (HP:0003396)1.60966723
182Spinal cord lesions (HP:0100561)1.60966723
183Hypoplasia of the capital femoral epiphysis (HP:0003090)1.57681786
184Microvesicular hepatic steatosis (HP:0001414)1.56395419
185Spastic diplegia (HP:0001264)1.55531201
186Poikiloderma (HP:0001029)1.54648242
187Abnormal delivery (HP:0001787)1.54124925
188Sparse eyelashes (HP:0000653)1.53474679
189Delayed cranial suture closure (HP:0000270)1.52735986
190Stridor (HP:0010307)1.52022518
191High anterior hairline (HP:0009890)1.51774030
192Joint laxity (HP:0001388)1.51424923

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.42016820
2SMG13.79131675
3MAP4K13.76678550
4EEF2K3.35189585
5CAMK1D3.30918641
6ERN13.15423826
7MAP3K103.02501847
8EPHA22.92922924
9SIK12.55106396
10PKN22.42988122
11BUB12.39584816
12ICK2.33421504
13CAMK1G2.22669111
14JAK32.04071762
15ZAP702.03284589
16TTK1.93488967
17PRPF4B1.87985668
18BCKDK1.73207473
19LRRK21.69157405
20STK101.63260821
21CDK121.59517520
22VRK21.57020823
23MAP2K31.55632410
24TEC1.51585394
25GRK61.45704972
26CDK41.45551417
27BTK1.43974325
28FLT31.39895896
29LATS21.33929198
30CSF1R1.32539523
31MET1.31670510
32TYK21.31476309
33TGFBR21.27679378
34NME21.27264929
35FGFR31.25614982
36PBK1.23631123
37CDK91.23499138
38SYK1.21527702
39KDR1.21493244
40CDK81.21249384
41TAOK21.16014773
42ITK1.15694961
43NEK21.14400610
44CDK61.14262307
45PTK21.13666946
46TXK1.12093157
47SRPK11.11727367
48CHEK21.10981773
49RIPK11.08855278
50TSSK61.07918020
51RPS6KB21.07308208
52TBK11.05045770
53KIT1.04072992
54JAK11.03253602
55SCYL21.00636693
56TESK11.00296644
57TTN0.99356305
58MAPKAPK30.98972338
59PIM10.98676727
60CSK0.95059993
61RPS6KA40.94878049
62FGFR40.92382497
63NEK10.91572784
64LCK0.89937091
65BLK0.89656038
66PIM20.87013823
67MAP3K110.86332276
68BMX0.86031678
69CLK10.85855744
70ARAF0.83774032
71AURKA0.82199249
72TGFBR10.81933096
73MAP3K80.81297133
74HCK0.80789973
75CHEK10.79838772
76LMTK20.79391812
77PDK40.77887975
78PDK30.77887975
79TESK20.76852213
80BRAF0.76170238
81TAF10.74359764
82JAK20.74302606
83PRKAA20.73920623
84IKBKE0.73880994
85TNK20.73808189
86MAP3K70.73002925
87CDC70.72753117
88MAPK110.72574771
89ILK0.71571525
90LATS10.70808302
91MAP3K30.70329982
92IKBKB0.69772356
93IRAK20.69298008
94TAOK10.68431241
95NTRK10.67926620
96MTOR0.67103413
97PAK20.67064230
98IRAK30.66764231
99NLK0.65370557
100BRSK10.65000571
101STK40.64902988
102LYN0.64252425
103MST1R0.63220002
104KSR20.63086085
105NME10.61278330
106PLK10.60492673
107WEE10.57968328
108MAP2K20.55497709
109ERBB40.54308645
110PRKCI0.53947351
111SIK20.53049540
112CHUK0.52815310
113MAP3K140.52680729
114PTK60.52253189
115CDK70.50389168
116AKT20.49893059
117RPS6KA20.48962665
118BRD40.48828757
119PASK0.45828502
120ATR0.45261633
121RPS6KC10.44137762
122RPS6KL10.44137762
123MELK0.43887318
124CDK20.42569266
125PDGFRA0.42010777
126MST40.41711928
127CDK10.41017633
128AURKB0.40249811
129NEK90.40066406
130PAK40.39444388
131PDK10.39044893
132PRKD20.38882377
133PAK10.38842816
134MAPKAPK20.38677059
135MAPK40.37759460
136PDGFRB0.37603478
137EIF2AK30.37537620
138RPS6KB10.37443654
139TLK10.36686533
140PRKG20.36182185
141TRPM70.35320978
142PRKCH0.34629668
143PLK30.34456630
144MAP3K130.34372177
145EIF2AK10.34210569
146IRAK40.33882269
147ALK0.33010939
148DMPK0.32815251
149MAP3K90.32607236
150RAF10.31808957
151DDR20.30520567
152EIF2AK20.30356746

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.32689665
2Fatty acid biosynthesis_Homo sapiens_hsa000612.81193604
3Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.67900775
4DNA replication_Homo sapiens_hsa030302.34702245
5PPAR signaling pathway_Homo sapiens_hsa033202.08540917
6Propanoate metabolism_Homo sapiens_hsa006402.03854276
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.00037506
8B cell receptor signaling pathway_Homo sapiens_hsa046621.93251154
9Ribosome_Homo sapiens_hsa030101.89808394
10Glycerolipid metabolism_Homo sapiens_hsa005611.87078957
11Bladder cancer_Homo sapiens_hsa052191.80914079
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.78287424
13Adipocytokine signaling pathway_Homo sapiens_hsa049201.73972701
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.70522220
15Mismatch repair_Homo sapiens_hsa034301.65371409
16Base excision repair_Homo sapiens_hsa034101.64521154
17Acute myeloid leukemia_Homo sapiens_hsa052211.64298062
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.61412579
19Vitamin B6 metabolism_Homo sapiens_hsa007501.59427341
20AMPK signaling pathway_Homo sapiens_hsa041521.46240642
21Measles_Homo sapiens_hsa051621.45186691
22Antigen processing and presentation_Homo sapiens_hsa046121.44952565
23Pentose phosphate pathway_Homo sapiens_hsa000301.41788502
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.38393002
25Hematopoietic cell lineage_Homo sapiens_hsa046401.38024526
26Fructose and mannose metabolism_Homo sapiens_hsa000511.36474089
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.34009128
28Fatty acid metabolism_Homo sapiens_hsa012121.30390429
29Galactose metabolism_Homo sapiens_hsa000521.29645470
30Osteoclast differentiation_Homo sapiens_hsa043801.27848394
31T cell receptor signaling pathway_Homo sapiens_hsa046601.27630566
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26481362
33Leishmaniasis_Homo sapiens_hsa051401.26417174
34Chronic myeloid leukemia_Homo sapiens_hsa052201.23642364
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.21485489
36MicroRNAs in cancer_Homo sapiens_hsa052061.21456041
37Small cell lung cancer_Homo sapiens_hsa052221.21269761
38Insulin resistance_Homo sapiens_hsa049311.17900752
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16967330
40Herpes simplex infection_Homo sapiens_hsa051681.16833851
41Toxoplasmosis_Homo sapiens_hsa051451.16094365
42Non-homologous end-joining_Homo sapiens_hsa034501.13491377
43Proteasome_Homo sapiens_hsa030501.10587240
44Carbon metabolism_Homo sapiens_hsa012001.09713930
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09017586
46Endometrial cancer_Homo sapiens_hsa052131.07642567
47Viral myocarditis_Homo sapiens_hsa054161.06097405
48Spliceosome_Homo sapiens_hsa030401.04525260
49Pyruvate metabolism_Homo sapiens_hsa006201.03246900
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02404435
51Fatty acid degradation_Homo sapiens_hsa000711.01688705
52Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00553334
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98597751
54Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.97669863
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97273658
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97221048
57Adherens junction_Homo sapiens_hsa045200.96699286
58Legionellosis_Homo sapiens_hsa051340.96636206
59Prostate cancer_Homo sapiens_hsa052150.96283807
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95650533
61ECM-receptor interaction_Homo sapiens_hsa045120.95317861
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.94952234
63HTLV-I infection_Homo sapiens_hsa051660.93641603
64Viral carcinogenesis_Homo sapiens_hsa052030.92450010
65Apoptosis_Homo sapiens_hsa042100.92235164
66One carbon pool by folate_Homo sapiens_hsa006700.90720424
67Notch signaling pathway_Homo sapiens_hsa043300.90307003
68Caffeine metabolism_Homo sapiens_hsa002320.89814670
69Proteoglycans in cancer_Homo sapiens_hsa052050.89317996
70Sulfur relay system_Homo sapiens_hsa041220.89009192
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.87984075
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87663020
73Autoimmune thyroid disease_Homo sapiens_hsa053200.87325254
74Insulin signaling pathway_Homo sapiens_hsa049100.86494850
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86392479
76HIF-1 signaling pathway_Homo sapiens_hsa040660.86223186
77RNA transport_Homo sapiens_hsa030130.85498661
78Hepatitis B_Homo sapiens_hsa051610.84354210
79Homologous recombination_Homo sapiens_hsa034400.83169776
80Thyroid cancer_Homo sapiens_hsa052160.82265843
81Selenocompound metabolism_Homo sapiens_hsa004500.81609202
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.80085051
83Cell cycle_Homo sapiens_hsa041100.79990180
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79632289
85Pancreatic cancer_Homo sapiens_hsa052120.79577575
86Platelet activation_Homo sapiens_hsa046110.79218104
87Fat digestion and absorption_Homo sapiens_hsa049750.75981513
88Nucleotide excision repair_Homo sapiens_hsa034200.75150954
89RNA polymerase_Homo sapiens_hsa030200.74024711
90Epstein-Barr virus infection_Homo sapiens_hsa051690.73636006
91mTOR signaling pathway_Homo sapiens_hsa041500.72349923
92Influenza A_Homo sapiens_hsa051640.72206881
93Hippo signaling pathway_Homo sapiens_hsa043900.72142926
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71079128
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68698166
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68486432
97Basal cell carcinoma_Homo sapiens_hsa052170.68010384
98beta-Alanine metabolism_Homo sapiens_hsa004100.67758204
99Shigellosis_Homo sapiens_hsa051310.67033183
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66642649
101Fanconi anemia pathway_Homo sapiens_hsa034600.66240888
102Glioma_Homo sapiens_hsa052140.66096253
103Melanoma_Homo sapiens_hsa052180.65732841
104p53 signaling pathway_Homo sapiens_hsa041150.65495608
105Colorectal cancer_Homo sapiens_hsa052100.64655700
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64487381
107Non-small cell lung cancer_Homo sapiens_hsa052230.63636964
108Renal cell carcinoma_Homo sapiens_hsa052110.63231958
109Toll-like receptor signaling pathway_Homo sapiens_hsa046200.62307134
110Vibrio cholerae infection_Homo sapiens_hsa051100.62254666
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61849612
112Allograft rejection_Homo sapiens_hsa053300.61629594
113Malaria_Homo sapiens_hsa051440.61071438
114Steroid biosynthesis_Homo sapiens_hsa001000.60597825
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60292876
116Systemic lupus erythematosus_Homo sapiens_hsa053220.59581020
117Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57497043
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57193426
119TNF signaling pathway_Homo sapiens_hsa046680.56682109
120Prion diseases_Homo sapiens_hsa050200.56196062
121Lysine degradation_Homo sapiens_hsa003100.55500022
122Folate biosynthesis_Homo sapiens_hsa007900.55095002
123VEGF signaling pathway_Homo sapiens_hsa043700.54480557
124N-Glycan biosynthesis_Homo sapiens_hsa005100.53627950
125Renin-angiotensin system_Homo sapiens_hsa046140.53328126
126ErbB signaling pathway_Homo sapiens_hsa040120.52995387
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52723297
128Glutathione metabolism_Homo sapiens_hsa004800.52489051
129NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51618660
130Other glycan degradation_Homo sapiens_hsa005110.51116959
131Hepatitis C_Homo sapiens_hsa051600.50701591
132Pertussis_Homo sapiens_hsa051330.50044147
133* Central carbon metabolism in cancer_Homo sapiens_hsa052300.49915899
134Staphylococcus aureus infection_Homo sapiens_hsa051500.49580529
135Pyrimidine metabolism_Homo sapiens_hsa002400.49477223
136Arginine biosynthesis_Homo sapiens_hsa002200.49047681
137Biosynthesis of amino acids_Homo sapiens_hsa012300.48690231
138Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48355519
139Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48267838
140mRNA surveillance pathway_Homo sapiens_hsa030150.48066953
141Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47822496
142Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47544784
143Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47193303
144Focal adhesion_Homo sapiens_hsa045100.46987775
145TGF-beta signaling pathway_Homo sapiens_hsa043500.46199653
146Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46142208
147Pathways in cancer_Homo sapiens_hsa052000.44628151
148Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44244049
149Fatty acid elongation_Homo sapiens_hsa000620.44119730
150Wnt signaling pathway_Homo sapiens_hsa043100.43743145

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