SLC1A6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)7.34241384
2cerebellar granule cell differentiation (GO:0021707)7.33816851
3locomotory exploration behavior (GO:0035641)6.59007010
4neuronal action potential propagation (GO:0019227)5.99064092
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.52599678
6synaptic vesicle maturation (GO:0016188)5.52063991
7cerebellar Purkinje cell differentiation (GO:0021702)5.51677622
8gamma-aminobutyric acid transport (GO:0015812)5.44299636
9ionotropic glutamate receptor signaling pathway (GO:0035235)5.42138265
10sodium ion export (GO:0071436)5.36449443
11G-protein coupled glutamate receptor signaling pathway (GO:0007216)5.33277082
12cellular potassium ion homeostasis (GO:0030007)5.31253169
13regulation of short-term neuronal synaptic plasticity (GO:0048172)5.30836073
14vocalization behavior (GO:0071625)5.28888313
15behavioral response to nicotine (GO:0035095)5.23545717
16glutamate receptor signaling pathway (GO:0007215)5.19908242
17cell differentiation in hindbrain (GO:0021533)5.10475304
18positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.88563588
19neurotransmitter secretion (GO:0007269)4.85450413
20positive regulation of synapse maturation (GO:0090129)4.84443018
21synaptic vesicle exocytosis (GO:0016079)4.79792053
22synaptic transmission, glutamatergic (GO:0035249)4.75048921
23regulation of synaptic vesicle exocytosis (GO:2000300)4.70363040
24regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.67509264
25regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.54265669
26glutamate secretion (GO:0014047)4.48708577
27exploration behavior (GO:0035640)4.40955931
28gamma-aminobutyric acid signaling pathway (GO:0007214)4.40005532
29neuromuscular process controlling posture (GO:0050884)4.29000444
30layer formation in cerebral cortex (GO:0021819)4.27022799
31cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.24668826
32neuron-neuron synaptic transmission (GO:0007270)4.21432320
33gonadal mesoderm development (GO:0007506)4.16820026
34long-term memory (GO:0007616)4.15851689
35positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.14506977
36regulation of synaptic vesicle transport (GO:1902803)3.99982298
37synaptic vesicle docking involved in exocytosis (GO:0016081)3.98959928
38retinal cone cell development (GO:0046549)3.94883197
39cell communication by electrical coupling (GO:0010644)3.94807814
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.94766834
41neuromuscular process controlling balance (GO:0050885)3.87957417
42negative regulation of synaptic transmission, GABAergic (GO:0032229)3.87062290
43regulation of glutamate receptor signaling pathway (GO:1900449)3.86042514
44neurotransmitter transport (GO:0006836)3.78310185
45potassium ion import (GO:0010107)3.72127854
46establishment of nucleus localization (GO:0040023)3.63394153
47dendrite morphogenesis (GO:0048813)3.61663658
48regulation of excitatory postsynaptic membrane potential (GO:0060079)3.59453729
49detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.57120291
50fucose catabolic process (GO:0019317)3.54685372
51L-fucose metabolic process (GO:0042354)3.54685372
52L-fucose catabolic process (GO:0042355)3.54685372
53auditory receptor cell stereocilium organization (GO:0060088)3.54654593
54transmission of nerve impulse (GO:0019226)3.54632939
55regulation of synapse maturation (GO:0090128)3.54496628
56regulation of neurotransmitter levels (GO:0001505)3.53546218
57regulation of long-term neuronal synaptic plasticity (GO:0048169)3.52718251
58membrane depolarization during action potential (GO:0086010)3.51907619
59negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.49370652
60serotonin metabolic process (GO:0042428)3.47947291
61neuron cell-cell adhesion (GO:0007158)3.46467904
62synaptic vesicle endocytosis (GO:0048488)3.45514576
63potassium ion homeostasis (GO:0055075)3.44669659
64protein localization to synapse (GO:0035418)3.44244360
65adult walking behavior (GO:0007628)3.42680411
66positive regulation of synapse assembly (GO:0051965)3.41762499
67short-term memory (GO:0007614)3.41082339
68cellular sodium ion homeostasis (GO:0006883)3.40026539
69detection of light stimulus involved in sensory perception (GO:0050962)3.36573486
70detection of light stimulus involved in visual perception (GO:0050908)3.36573486
71regulation of synapse structural plasticity (GO:0051823)3.36309384
72glycine transport (GO:0015816)3.33476009
73regulation of postsynaptic membrane potential (GO:0060078)3.33392288
74primary amino compound metabolic process (GO:1901160)3.32264337
75negative regulation of microtubule polymerization (GO:0031115)3.31175323
76neurotransmitter-gated ion channel clustering (GO:0072578)3.29962688
77positive regulation of potassium ion transmembrane transport (GO:1901381)3.28764745
78regulation of voltage-gated calcium channel activity (GO:1901385)3.28191097
79regulation of neurotransmitter secretion (GO:0046928)3.27825307
80dendritic spine morphogenesis (GO:0060997)3.27731162
81positive regulation of membrane potential (GO:0045838)3.25638745
82regulation of neuronal synaptic plasticity (GO:0048168)3.21424734
83activation of protein kinase A activity (GO:0034199)3.21253823
84inner ear receptor stereocilium organization (GO:0060122)3.20117835
85membrane depolarization (GO:0051899)3.19402993
86cerebellar Purkinje cell layer development (GO:0021680)3.18193941
87positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.18114077
88negative regulation of cytosolic calcium ion concentration (GO:0051481)3.13351464
89prepulse inhibition (GO:0060134)3.10941162
90neuromuscular process (GO:0050905)3.09910718
91presynaptic membrane organization (GO:0097090)3.07574746
92synapse assembly (GO:0007416)3.07505122
93multicellular organismal movement (GO:0050879)3.07395998
94musculoskeletal movement (GO:0050881)3.07395998
95long term synaptic depression (GO:0060292)3.05784193
96auditory behavior (GO:0031223)3.05589443
97proline transport (GO:0015824)3.05261039
98regulation of vesicle fusion (GO:0031338)3.04549518
99axonal fasciculation (GO:0007413)3.03570418
100neurofilament cytoskeleton organization (GO:0060052)3.03160947
101negative regulation of hormone metabolic process (GO:0032351)3.02949919
102negative regulation of hormone biosynthetic process (GO:0032353)3.02949919
103regulation of neurotransmitter transport (GO:0051588)2.99095765
104mechanosensory behavior (GO:0007638)2.98051894
105regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.97394958
106detection of temperature stimulus involved in sensory perception (GO:0050961)2.96858262
107detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.96858262
108presynaptic membrane assembly (GO:0097105)2.96752215
109regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.96252674
110regulation of synaptic transmission, glutamatergic (GO:0051966)2.96022397
111neuronal action potential (GO:0019228)2.93171907
112synapse organization (GO:0050808)2.92505769
113membrane repolarization (GO:0086009)2.91977527
114membrane hyperpolarization (GO:0060081)2.91425850
115postsynaptic membrane organization (GO:0001941)2.90754353
116neuron recognition (GO:0008038)2.89227805
117long-term synaptic potentiation (GO:0060291)2.86352225
118behavioral response to ethanol (GO:0048149)2.85268678
119cytoskeletal anchoring at plasma membrane (GO:0007016)2.85073041
120positive regulation of potassium ion transport (GO:0043268)2.84686148
121positive regulation of fibroblast migration (GO:0010763)2.83445381
122indole-containing compound metabolic process (GO:0042430)2.81152814
123neuromuscular synaptic transmission (GO:0007274)2.81028705
124indolalkylamine metabolic process (GO:0006586)2.78370876
125rhodopsin mediated signaling pathway (GO:0016056)2.77687366
126tryptophan catabolic process (GO:0006569)2.76231517
127indole-containing compound catabolic process (GO:0042436)2.76231517
128indolalkylamine catabolic process (GO:0046218)2.76231517
129aggressive behavior (GO:0002118)2.74012376
130startle response (GO:0001964)2.73226628
131reflex (GO:0060004)2.72914243
132axon ensheathment in central nervous system (GO:0032291)2.72451568
133central nervous system myelination (GO:0022010)2.72451568
134potassium ion transmembrane transport (GO:0071805)2.71435902
135cellular potassium ion transport (GO:0071804)2.71435902
136kynurenine metabolic process (GO:0070189)2.70044110
137regulation of calcium ion-dependent exocytosis (GO:0017158)2.69186619
138protein polyglutamylation (GO:0018095)2.63902221
139retina layer formation (GO:0010842)2.63326148
140adult behavior (GO:0030534)2.62483864
141cochlea development (GO:0090102)2.62244840
142glycosphingolipid biosynthetic process (GO:0006688)2.61551930
143positive regulation of synaptic transmission, GABAergic (GO:0032230)2.61136678
144potassium ion transport (GO:0006813)2.60268265
145dopamine transport (GO:0015872)2.59143893
146regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.59078345
147protein localization to cilium (GO:0061512)2.57731853
148parturition (GO:0007567)2.56353257
149neurotransmitter metabolic process (GO:0042133)2.56005730
150* synaptic transmission (GO:0007268)2.54770707
151protein complex biogenesis (GO:0070271)2.53442786
152synaptic transmission, cholinergic (GO:0007271)2.52368164
153axoneme assembly (GO:0035082)2.51530392
154negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.49718562
155dopamine biosynthetic process (GO:0042416)2.49431315
156protein K11-linked deubiquitination (GO:0035871)2.47395005
157photoreceptor cell maintenance (GO:0045494)2.47189272

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.60990876
2* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.49681712
3VDR_22108803_ChIP-Seq_LS180_Human3.23141197
4IKZF1_21737484_ChIP-ChIP_HCT116_Human3.16156385
5RNF2_18974828_ChIP-Seq_MESCs_Mouse3.15295187
6EZH2_18974828_ChIP-Seq_MESCs_Mouse3.15295187
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13522271
8JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07638642
9DROSHA_22980978_ChIP-Seq_HELA_Human2.91442998
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.80523546
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.74497038
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.73989181
13* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.67607275
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.63566155
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.63253320
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.61170940
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.59581746
18TAF15_26573619_Chip-Seq_HEK293_Human2.58598121
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.57391937
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.56425878
21REST_21632747_ChIP-Seq_MESCs_Mouse2.56197400
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.47537977
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.41852111
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.39759342
25IGF1R_20145208_ChIP-Seq_DFB_Human2.36648316
26EZH2_27304074_Chip-Seq_ESCs_Mouse2.35095368
27GBX2_23144817_ChIP-Seq_PC3_Human2.34769603
28RNF2_27304074_Chip-Seq_ESCs_Mouse2.30417745
29POU3F2_20337985_ChIP-ChIP_501MEL_Human2.29771437
30SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24240526
31RARB_27405468_Chip-Seq_BRAIN_Mouse2.15167656
32REST_18959480_ChIP-ChIP_MESCs_Mouse2.13846964
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.06114902
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.04089217
35FUS_26573619_Chip-Seq_HEK293_Human2.03583458
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.99288100
37ZNF274_21170338_ChIP-Seq_K562_Hela1.91666497
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83021469
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82391603
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.80663411
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77950241
42EWS_26573619_Chip-Seq_HEK293_Human1.73607051
43BCAT_22108803_ChIP-Seq_LS180_Human1.69208871
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68640909
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66966918
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56531623
47ER_23166858_ChIP-Seq_MCF-7_Human1.56426352
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53644970
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.53250699
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51514676
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.51514676
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.50228552
53DNAJC2_21179169_ChIP-ChIP_NT2_Human1.49713315
54KDM2B_26808549_Chip-Seq_K562_Human1.49022346
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47570504
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.45804637
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44875843
58AR_21572438_ChIP-Seq_LNCaP_Human1.40398047
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40346373
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.39616249
61* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38677236
62NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37656363
63SMAD4_21799915_ChIP-Seq_A2780_Human1.37297251
64CBP_20019798_ChIP-Seq_JUKART_Human1.36884225
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36884225
66RING1B_27294783_Chip-Seq_ESCs_Mouse1.34906970
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34757194
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33685990
69AR_19668381_ChIP-Seq_PC3_Human1.32325241
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31774421
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31116442
72TP53_22573176_ChIP-Seq_HFKS_Human1.30348140
73TCF4_22108803_ChIP-Seq_LS180_Human1.29869954
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29487511
75RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.28679993
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28123080
77* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27575233
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25668177
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24748298
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24648109
81SOX2_19829295_ChIP-Seq_ESCs_Human1.24517985
82NANOG_19829295_ChIP-Seq_ESCs_Human1.24517985
83HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21211639
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21035820
85* FLI1_21867929_ChIP-Seq_TH2_Mouse1.20532439
86RING1B_27294783_Chip-Seq_NPCs_Mouse1.20284868
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20157456
88PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19869903
89TP53_16413492_ChIP-PET_HCT116_Human1.19859163
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19309779
91PRDM14_20953172_ChIP-Seq_ESCs_Human1.18903834
92SMAD_19615063_ChIP-ChIP_OVARY_Human1.18505659
93TP53_20018659_ChIP-ChIP_R1E_Mouse1.18207391
94SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17890718
95TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17388047
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17031473
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.13957030
98ZFP281_27345836_Chip-Seq_ESCs_Mouse1.13263314
99HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13159356
100NANOG_18555785_Chip-Seq_ESCs_Mouse1.12733290
101WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11802253
102SOX2_21211035_ChIP-Seq_LN229_Gbm1.10638502
103NFE2_27457419_Chip-Seq_LIVER_Mouse1.09865156
104NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09755660
105TET1_21490601_ChIP-Seq_MESCs_Mouse1.09300902
106ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08600497
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08176176
108SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08083292
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07167396
110ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07074898
111EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06477271
112GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06090588
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05776132
114CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04670198
115P53_22387025_ChIP-Seq_ESCs_Mouse1.02542607
116CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00965053
117CBX2_27304074_Chip-Seq_ESCs_Mouse1.00111124
118AR_25329375_ChIP-Seq_VCAP_Human1.00050406
119SMAD3_21741376_ChIP-Seq_ESCs_Human0.98586905
120STAT3_23295773_ChIP-Seq_U87_Human0.97546493
121CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96851992
122RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96437968
123DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96189520
124BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95006637
125OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94871948
126SMAD4_21741376_ChIP-Seq_HESCs_Human0.94539853
127KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94401502
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92213326
129MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92129065
130EP300_21415370_ChIP-Seq_HL-1_Mouse0.90122468
131ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89905764
132CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89374671
133YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88814061
134SMAD4_21741376_ChIP-Seq_EPCs_Human0.88237313
135OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88141677
136SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87713951
137ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87472682
138RXR_22108803_ChIP-Seq_LS180_Human0.83097062
139RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.82900371
140SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82894575
141PIAS1_25552417_ChIP-Seq_VCAP_Human0.81684517
142TOP2B_26459242_ChIP-Seq_MCF-7_Human0.81445572
143* TCF4_23295773_ChIP-Seq_U87_Human0.81120754
144ARNT_22903824_ChIP-Seq_MCF-7_Human0.80582291
145RNF2_27304074_Chip-Seq_NSC_Mouse0.80265723
146KLF4_19829295_ChIP-Seq_ESCs_Human0.79520277
147KDM2B_26808549_Chip-Seq_JURKAT_Human0.77955324
148SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76544661
149RUNX2_22187159_ChIP-Seq_PCA_Human0.76073679
150P300_19829295_ChIP-Seq_ESCs_Human0.75934467
151BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75258109

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.66360066
2MP0009046_muscle_twitch4.71390084
3MP0003635_abnormal_synaptic_transmissio4.04546211
4MP0008569_lethality_at_weaning3.25043280
5MP0009745_abnormal_behavioral_response3.09006261
6MP0002064_seizures3.07573947
7MP0003880_abnormal_central_pattern3.02414695
8MP0004145_abnormal_muscle_electrophysio3.01819795
9MP0001968_abnormal_touch/_nociception2.97619587
10MP0004270_analgesia2.91772982
11MP0002063_abnormal_learning/memory/cond2.82890492
12* MP0002272_abnormal_nervous_system2.82103257
13MP0001440_abnormal_grooming_behavior2.65832503
14MP0002734_abnormal_mechanical_nocicepti2.63864916
15MP0005423_abnormal_somatic_nervous2.63802916
16MP0008877_abnormal_DNA_methylation2.61915139
17MP0002572_abnormal_emotion/affect_behav2.57414646
18MP0002067_abnormal_sensory_capabilities2.46338063
19MP0002736_abnormal_nociception_after2.44381455
20MP0002184_abnormal_innervation2.40905508
21MP0001486_abnormal_startle_reflex2.14413891
22MP0001501_abnormal_sleep_pattern2.13987384
23MP0003329_amyloid_beta_deposits2.12968654
24MP0002735_abnormal_chemical_nociception2.12194962
25MP0002733_abnormal_thermal_nociception1.92954875
26MP0004142_abnormal_muscle_tone1.91662420
27MP0010386_abnormal_urinary_bladder1.89040393
28MP0005646_abnormal_pituitary_gland1.87244640
29MP0004885_abnormal_endolymph1.81866096
30MP0001970_abnormal_pain_threshold1.80961148
31MP0002557_abnormal_social/conspecific_i1.80477024
32MP0008875_abnormal_xenobiotic_pharmacok1.77450323
33MP0002638_abnormal_pupillary_reflex1.75426982
34MP0005623_abnormal_meninges_morphology1.74693241
35MP0000955_abnormal_spinal_cord1.72294453
36MP0003195_calcinosis1.66718534
37MP0004742_abnormal_vestibular_system1.65682698
38MP0005386_behavior/neurological_phenoty1.63408324
39MP0004924_abnormal_behavior1.63408324
40MP0004858_abnormal_nervous_system1.63054938
41MP0002066_abnormal_motor_capabilities/c1.57445181
42MP0000778_abnormal_nervous_system1.57435567
43MP0000013_abnormal_adipose_tissue1.56598701
44MP0002102_abnormal_ear_morphology1.56294548
45MP0003632_abnormal_nervous_system1.55034978
46MP0004811_abnormal_neuron_physiology1.54291106
47MP0002837_dystrophic_cardiac_calcinosis1.52907448
48MP0003283_abnormal_digestive_organ1.43842617
49MP0004147_increased_porphyrin_level1.37374386
50MP0005253_abnormal_eye_physiology1.36014900
51MP0002882_abnormal_neuron_morphology1.34888142
52MP0003122_maternal_imprinting1.30719917
53MP0003646_muscle_fatigue1.30020062
54MP0003879_abnormal_hair_cell1.28862727
55MP0006292_abnormal_olfactory_placode1.28115579
56MP0001986_abnormal_taste_sensitivity1.26522381
57MP0009780_abnormal_chondrocyte_physiolo1.26321798
58MP0001299_abnormal_eye_distance/1.26002581
59MP0003631_nervous_system_phenotype1.25513499
60MP0003136_yellow_coat_color1.25208672
61MP0001502_abnormal_circadian_rhythm1.24776916
62MP0003633_abnormal_nervous_system1.21451660
63MP0002876_abnormal_thyroid_physiology1.20944024
64MP0000631_abnormal_neuroendocrine_gland1.19879632
65MP0002152_abnormal_brain_morphology1.19442571
66MP0002909_abnormal_adrenal_gland1.18987855
67MP0006276_abnormal_autonomic_nervous1.18832869
68MP0002089_abnormal_postnatal_growth/wei1.17488837
69MP0000372_irregular_coat_pigmentation1.17310057
70MP0001984_abnormal_olfaction1.14808334
71MP0006035_abnormal_mitochondrial_morpho1.10745407
72MP0000920_abnormal_myelination1.09877490
73MP0003121_genomic_imprinting1.08061894
74MP0000427_abnormal_hair_cycle1.06897565
75MP0000751_myopathy1.05734641
76MP0005410_abnormal_fertilization1.03020413
77MP0003045_fibrosis1.01588469
78MP0004133_heterotaxia0.99650683
79MP0002160_abnormal_reproductive_system0.99047898
80MP0005174_abnormal_tail_pigmentation0.98701134
81MP0001348_abnormal_lacrimal_gland0.97336136
82MP0008438_abnormal_cutaneous_collagen0.96497802
83MP0004233_abnormal_muscle_weight0.91725636
84MP0003690_abnormal_glial_cell0.90858806
85MP0002653_abnormal_ependyma_morphology0.90627625
86MP0003634_abnormal_glial_cell0.89241190
87MP0004215_abnormal_myocardial_fiber0.88646596
88MP0003137_abnormal_impulse_conducting0.87212193
89MP0001177_atelectasis0.87183719
90MP0000604_amyloidosis0.86820652
91MP0001905_abnormal_dopamine_level0.86699134
92MP0005645_abnormal_hypothalamus_physiol0.86498092
93MP0002229_neurodegeneration0.86448858
94MP0008872_abnormal_physiological_respon0.83935764
95MP0002938_white_spotting0.82431354
96MP0003705_abnormal_hypodermis_morpholog0.81794415
97MP0002234_abnormal_pharynx_morphology0.80802355
98MP0003698_abnormal_male_reproductive0.78852933
99MP0004484_altered_response_of0.78451578
100MP0005389_reproductive_system_phenotype0.78380648
101MP0002069_abnormal_eating/drinking_beha0.76569306
102MP0005187_abnormal_penis_morphology0.76058807
103MP0000747_muscle_weakness0.74820468
104MP0005167_abnormal_blood-brain_barrier0.74173618
105MP0005503_abnormal_tendon_morphology0.73339220
106MP0001529_abnormal_vocalization0.72719593
107MP0003011_delayed_dark_adaptation0.71622135
108MP0000026_abnormal_inner_ear0.70373460
109MP0004043_abnormal_pH_regulation0.70301896
110MP0003279_aneurysm0.70284803
111MP0003787_abnormal_imprinting0.70152567
112MP0005195_abnormal_posterior_eye0.68778835
113MP0002752_abnormal_somatic_nervous0.68114625
114MP0001963_abnormal_hearing_physiology0.67399420
115MP0000230_abnormal_systemic_arterial0.67307142
116MP0004085_abnormal_heartbeat0.66147858
117MP0003861_abnormal_nervous_system0.64837229
118MP0002928_abnormal_bile_duct0.64243930
119MP0001958_emphysema0.64187205
120MP0010769_abnormal_survival0.64085392
121MP0006072_abnormal_retinal_apoptosis0.62029975
122MP0005551_abnormal_eye_electrophysiolog0.61949607
123MP0008874_decreased_physiological_sensi0.61689491
124MP0003385_abnormal_body_wall0.61655896
125MP0001188_hyperpigmentation0.61626717
126MP0000569_abnormal_digit_pigmentation0.61542239
127MP0005083_abnormal_biliary_tract0.61022872
128MP0010768_mortality/aging0.60504445
129MP0005394_taste/olfaction_phenotype0.59528686
130MP0005499_abnormal_olfactory_system0.59528686
131MP0000383_abnormal_hair_follicle0.59521172
132MP0005171_absent_coat_pigmentation0.59294638
133MP0002082_postnatal_lethality0.58737856
134MP0010770_preweaning_lethality0.58737856
135MP0002751_abnormal_autonomic_nervous0.58608314
136MP0001943_abnormal_respiration0.57971299
137MP0001485_abnormal_pinna_reflex0.57955044
138MP0000003_abnormal_adipose_tissue0.53443721

Predicted human phenotypes

RankGene SetZ-score
1Action tremor (HP:0002345)6.76113948
2Progressive cerebellar ataxia (HP:0002073)6.52973048
3Visual hallucinations (HP:0002367)5.63166580
4Focal motor seizures (HP:0011153)5.31115144
5Myokymia (HP:0002411)5.13185495
6Focal seizures (HP:0007359)5.09147073
7Atonic seizures (HP:0010819)4.94214833
8Gaze-evoked nystagmus (HP:0000640)4.86467096
9Scanning speech (HP:0002168)4.53024055
10Dysmetric saccades (HP:0000641)4.44872691
11Dysdiadochokinesis (HP:0002075)4.34540638
12Hemiplegia (HP:0002301)4.22031818
13Impaired smooth pursuit (HP:0007772)4.14349832
14Febrile seizures (HP:0002373)3.96337185
15Intention tremor (HP:0002080)3.84162335
16Abnormality of ocular smooth pursuit (HP:0000617)3.83303724
17Genetic anticipation (HP:0003743)3.78245417
18Absence seizures (HP:0002121)3.74834059
19Dysmetria (HP:0001310)3.69475487
20Hyperventilation (HP:0002883)3.61491657
21Epileptic encephalopathy (HP:0200134)3.60731626
22Broad-based gait (HP:0002136)3.57943692
23Abnormality of the lower motor neuron (HP:0002366)3.57163271
24Truncal ataxia (HP:0002078)3.56814373
25Pancreatic cysts (HP:0001737)3.53774860
26Abnormality of binocular vision (HP:0011514)3.51446118
27Diplopia (HP:0000651)3.51446118
28Hemiparesis (HP:0001269)3.42204455
29Pancreatic fibrosis (HP:0100732)3.36137106
30True hermaphroditism (HP:0010459)3.26846243
31Abnormality of midbrain morphology (HP:0002418)3.26294758
32Molar tooth sign on MRI (HP:0002419)3.26294758
33Tetraplegia (HP:0002445)3.19270274
34Dialeptic seizures (HP:0011146)3.17565200
35Generalized tonic-clonic seizures (HP:0002069)3.10022888
36Postural tremor (HP:0002174)3.08517409
37Congenital stationary night blindness (HP:0007642)3.07985495
38Shallow orbits (HP:0000586)3.06156518
39Nephronophthisis (HP:0000090)3.03111805
40Type II lissencephaly (HP:0007260)2.99499279
41Poor eye contact (HP:0000817)2.93762622
42Horizontal nystagmus (HP:0000666)2.93062319
43Supranuclear gaze palsy (HP:0000605)2.92756592
44Status epilepticus (HP:0002133)2.92605641
45Depression (HP:0000716)2.91007778
46Annular pancreas (HP:0001734)2.78794797
47Abnormal eating behavior (HP:0100738)2.73759455
48Impaired social interactions (HP:0000735)2.70722549
49Abnormal social behavior (HP:0012433)2.70722549
50Amyotrophic lateral sclerosis (HP:0007354)2.66392408
51Abnormality of saccadic eye movements (HP:0000570)2.62981383
52Abnormality of the renal medulla (HP:0100957)2.62048346
53Medial flaring of the eyebrow (HP:0010747)2.61755393
54Ventricular fibrillation (HP:0001663)2.61576399
55Inability to walk (HP:0002540)2.56758220
56Mutism (HP:0002300)2.55026466
57Limb ataxia (HP:0002070)2.52520929
58Broad metatarsal (HP:0001783)2.52415703
59Anxiety (HP:0000739)2.51678862
60Attenuation of retinal blood vessels (HP:0007843)2.51636837
61Agitation (HP:0000713)2.49875620
62Abnormality of the renal cortex (HP:0011035)2.48796047
63Progressive inability to walk (HP:0002505)2.48712307
64Acute necrotizing encephalopathy (HP:0006965)2.47762594
65Abnormal rod and cone electroretinograms (HP:0008323)2.46312272
66Myotonia (HP:0002486)2.45968975
67Abnormality of the corticospinal tract (HP:0002492)2.42934284
68Cystic liver disease (HP:0006706)2.38483256
69Limb dystonia (HP:0002451)2.36890519
70Hand muscle atrophy (HP:0009130)2.36647162
71Progressive macrocephaly (HP:0004481)2.36120117
72Abnormality of the labia minora (HP:0012880)2.33144190
73Decreased central vision (HP:0007663)2.31826170
74Gait imbalance (HP:0002141)2.31490352
75Ankle clonus (HP:0011448)2.28318943
76Lower limb asymmetry (HP:0100559)2.26460722
77Chronic hepatic failure (HP:0100626)2.26311405
78Gait ataxia (HP:0002066)2.25918076
79Absent rod-and cone-mediated responses on ERG (HP:0007688)2.25640697
80Abolished electroretinogram (ERG) (HP:0000550)2.24843211
81Abnormal drinking behavior (HP:0030082)2.23096850
82Polydipsia (HP:0001959)2.23096850
83Mitochondrial inheritance (HP:0001427)2.20895234
84Spastic gait (HP:0002064)2.20520016
85Pointed chin (HP:0000307)2.20185946
86Protrusio acetabuli (HP:0003179)2.16906607
87Postural instability (HP:0002172)2.15760802
88Acute encephalopathy (HP:0006846)2.15071351
89Spinal canal stenosis (HP:0003416)2.12004399
90Morphological abnormality of the pyramidal tract (HP:0002062)2.11792633
91Impaired vibration sensation in the lower limbs (HP:0002166)2.11609413
92Narrow nasal bridge (HP:0000446)2.09931545
93Neuronal loss in central nervous system (HP:0002529)2.09559904
94Upper limb amyotrophy (HP:0009129)2.08908668
95Distal upper limb amyotrophy (HP:0007149)2.08908668
96Cerebellar dysplasia (HP:0007033)2.08596564
97Slow progression (HP:0003677)2.07579108
98Increased CSF lactate (HP:0002490)2.05452152
99Stereotypic behavior (HP:0000733)2.03803617
100Congenital primary aphakia (HP:0007707)2.03677832
101Optic nerve hypoplasia (HP:0000609)2.03534086
102Polyphagia (HP:0002591)2.03190819
103Abnormal mitochondria in muscle tissue (HP:0008316)2.02976360
104Absent speech (HP:0001344)2.02045623
105Psychosis (HP:0000709)2.02032024
106Bundle branch block (HP:0011710)2.01730534
107Lissencephaly (HP:0001339)2.00874065
108Hypothermia (HP:0002045)2.00105212
109Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.97674105
110Tubular atrophy (HP:0000092)1.96002061
111Achilles tendon contracture (HP:0001771)1.95789669
112Nephrogenic diabetes insipidus (HP:0009806)1.95416184
113Pheochromocytoma (HP:0002666)1.93458013
114Pendular nystagmus (HP:0012043)1.92257853
115Premature rupture of membranes (HP:0001788)1.91613437
116Large for gestational age (HP:0001520)1.89616845
117Hypoventilation (HP:0002791)1.89457201
118Protruding tongue (HP:0010808)1.86709834
119Genital tract atresia (HP:0001827)1.85874302
120Stomach cancer (HP:0012126)1.85864090
121Renal cortical cysts (HP:0000803)1.85673344
122Neurofibrillary tangles (HP:0002185)1.84879274
123Abnormality of macular pigmentation (HP:0008002)1.84579124
124Urinary bladder sphincter dysfunction (HP:0002839)1.84451224
125Megalencephaly (HP:0001355)1.84061312
126Neoplasm of the heart (HP:0100544)1.84051298
127Aqueductal stenosis (HP:0002410)1.81805237
128Sclerocornea (HP:0000647)1.81698169
129Excessive salivation (HP:0003781)1.80065578
130Drooling (HP:0002307)1.80065578
131Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79647369
132Abnormality of alanine metabolism (HP:0010916)1.79647369
133Hyperalaninemia (HP:0003348)1.79647369
134Aplasia/Hypoplasia of the tibia (HP:0005772)1.78964440
135Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.78249547
136Degeneration of the lateral corticospinal tracts (HP:0002314)1.78249547
137Cerebral inclusion bodies (HP:0100314)1.78103003
138Vaginal atresia (HP:0000148)1.77609056
139Retinal dysplasia (HP:0007973)1.77060503
140Optic disc pallor (HP:0000543)1.76714814
141Overgrowth (HP:0001548)1.75739698
142Oligodactyly (hands) (HP:0001180)1.75327113
143Hepatocellular necrosis (HP:0001404)1.74640551
144Clonus (HP:0002169)1.74370296
145Polyuria (HP:0000103)1.74328683
146Bowel diverticulosis (HP:0005222)1.74111719
147Split foot (HP:0001839)1.72343585
148Abnormality of the Achilles tendon (HP:0005109)1.71301356
149Failure to thrive in infancy (HP:0001531)1.71087381
150Decreased electroretinogram (ERG) amplitude (HP:0000654)1.69035840
151Intestinal atresia (HP:0011100)1.68950686
152Furrowed tongue (HP:0000221)1.68874441
153Insomnia (HP:0100785)1.68807876
154Increased corneal curvature (HP:0100692)1.68717574
155Keratoconus (HP:0000563)1.68717574
156Amblyopia (HP:0000646)1.68406026
157Anencephaly (HP:0002323)1.67572889
158Bradykinesia (HP:0002067)1.67303226
159Incomplete penetrance (HP:0003829)1.67007173
160Fetal akinesia sequence (HP:0001989)1.65527673
161EEG with generalized epileptiform discharges (HP:0011198)1.64835908
162Epileptiform EEG discharges (HP:0011182)1.64399840
163Generalized hypotonia (HP:0001290)1.63536897
164Hypoplastic nipples (HP:0002557)1.62800333
165Hypsarrhythmia (HP:0002521)1.62262043
166Broad ribs (HP:0000885)1.61650418
167Urinary urgency (HP:0000012)1.61468443

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.31345605
2CAMKK23.98750608
3NTRK33.76386258
4RIPK13.24861177
5MAP3K92.99671518
6MINK12.82030777
7MAP3K42.74522373
8CAMKK12.63288946
9ADRBK22.60395824
10MAP4K22.59337489
11MARK12.56637269
12PAK62.43077061
13WNK12.37827719
14BMPR1B2.36686411
15CDK192.27631376
16ZAK2.26325487
17WNK32.22874051
18NTRK22.17459236
19STK381.99004032
20MAP2K41.93349546
21MAP2K71.89001901
22DAPK21.88763384
23TLK11.80192161
24TYRO31.70364219
25NUAK11.69383522
26GRK11.66425677
27INSRR1.60597075
28TAOK31.58048239
29PNCK1.52183543
30PRKCG1.48455885
31ACVR1B1.47241240
32LATS21.42661498
33PRPF4B1.41950218
34NTRK11.39344518
35PLK21.31863369
36KSR21.31651072
37SIK21.31568013
38UHMK11.30440579
39STK391.26919966
40CDK51.25015870
41CDK151.23515634
42GRK51.23506210
43CSNK1G21.21965426
44CDK181.19328380
45WNK41.18816615
46PRKCH1.16911637
47ALK1.16502042
48KSR11.13509800
49CAMK11.12694550
50CSNK1G11.12294823
51PHKG11.12167427
52PHKG21.12167427
53SGK4941.10205378
54SGK2231.10205378
55STK111.09659912
56CDK141.09495138
57CDK11A1.09379091
58MKNK21.09039910
59PRKCE1.08699667
60OXSR11.08417147
61CASK1.08090775
62RIPK41.06253248
63CSNK1G31.05366903
64MAPK131.04062289
65TRIM281.03012460
66PAK31.02970583
67FGFR20.97354153
68PTK20.93553199
69PTK60.93121025
70CSNK1A1L0.93087707
71MAPKAPK50.92761334
72CAMK2G0.91804121
73STK38L0.90615708
74DDR20.90321342
75CDC42BPA0.90058823
76PKN10.88144133
77RET0.86984737
78CAMK40.86519036
79SGK20.86209876
80SGK30.85813717
81EPHA40.85193056
82DYRK20.85134180
83CAMK1G0.84079496
84ROCK20.84021788
85CAMK2B0.83194898
86ADRBK10.82941826
87LMTK20.81081062
88CAMK2A0.80949071
89PRKD30.80409167
90TNIK0.76701485
91AKT30.75245628
92TRIB30.73182525
93TAF10.73161066
94PDGFRA0.73082885
95DYRK1A0.72972896
96MAP3K120.72534547
97CAMK2D0.69705238
98VRK10.69029191
99SCYL20.68246323
100CCNB10.66164888
101DAPK10.66057616
102TXK0.65802974
103LIMK10.65743174
104PINK10.65599865
105ARAF0.63160278
106MARK20.63016046
107FYN0.62238129
108BCR0.60212703
109TAOK10.60024547
110MAP2K60.59890068
111PTK2B0.59783308
112PDK10.58475142
113ERBB30.57558194
114SGK10.57521460
115CSNK1A10.57418122
116PDPK10.56098312
117MUSK0.56082949
118FER0.54580899
119RPS6KA30.54018705
120PLK30.53995180
121PRKG10.53510090
122TIE10.53102705
123PRKCZ0.51515806
124BMX0.51248437
125PRKCA0.49116664
126CSNK1D0.48880082
127EPHB10.47806554
128PRKCI0.46384324
129SRC0.44781445
130NEK60.44242427
131FES0.44195239
132MAPKAPK30.43894378
133MAP3K20.43153623
134TNK20.43106207
135BRSK20.41683709
136DAPK30.41613890
137PRKCQ0.40335060
138NEK10.39518085
139PRKACB0.39421228
140TGFBR10.37935149
141RPS6KA50.36954584
142MKNK10.36725145
143MAPK120.36529825
144MAPK100.36358921
145PRKDC0.35626886
146PRKACA0.35416274
147HIPK20.35326851
148PRKAA10.34349199
149CDK30.33596422

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.37067070
2Synaptic vesicle cycle_Homo sapiens_hsa047213.01512960
3Long-term potentiation_Homo sapiens_hsa047202.90392611
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.85860915
5* Glutamatergic synapse_Homo sapiens_hsa047242.83818658
6GABAergic synapse_Homo sapiens_hsa047272.71095941
7Circadian entrainment_Homo sapiens_hsa047132.67594298
8Long-term depression_Homo sapiens_hsa047302.60557320
9Phototransduction_Homo sapiens_hsa047442.49919567
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.36578136
11Morphine addiction_Homo sapiens_hsa050322.28739059
12Taste transduction_Homo sapiens_hsa047422.22292010
13Salivary secretion_Homo sapiens_hsa049702.20701368
14Amphetamine addiction_Homo sapiens_hsa050312.11914143
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.04775911
16Gastric acid secretion_Homo sapiens_hsa049711.89934166
17Oxidative phosphorylation_Homo sapiens_hsa001901.88440334
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.88435875
19Dopaminergic synapse_Homo sapiens_hsa047281.88122295
20Butanoate metabolism_Homo sapiens_hsa006501.79345623
21Olfactory transduction_Homo sapiens_hsa047401.73432293
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.68567099
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66913684
24Insulin secretion_Homo sapiens_hsa049111.65132814
25Cholinergic synapse_Homo sapiens_hsa047251.63595001
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62650557
27Linoleic acid metabolism_Homo sapiens_hsa005911.53898061
28Oxytocin signaling pathway_Homo sapiens_hsa049211.52822735
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.51733351
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46821966
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46077599
32Parkinsons disease_Homo sapiens_hsa050121.44521868
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.43507424
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.42065446
35Calcium signaling pathway_Homo sapiens_hsa040201.41244091
36Gap junction_Homo sapiens_hsa045401.40738739
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35006509
38Serotonergic synapse_Homo sapiens_hsa047261.33821712
39Type II diabetes mellitus_Homo sapiens_hsa049301.33231869
40GnRH signaling pathway_Homo sapiens_hsa049121.33196088
41Ether lipid metabolism_Homo sapiens_hsa005651.30234921
42Estrogen signaling pathway_Homo sapiens_hsa049151.29354813
43cAMP signaling pathway_Homo sapiens_hsa040241.24893860
44Renin secretion_Homo sapiens_hsa049241.23899224
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19582325
46Cocaine addiction_Homo sapiens_hsa050301.18357336
47Thyroid hormone synthesis_Homo sapiens_hsa049181.16599836
48Pancreatic secretion_Homo sapiens_hsa049721.13760080
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09994085
50Cardiac muscle contraction_Homo sapiens_hsa042601.08200006
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08016071
52Tryptophan metabolism_Homo sapiens_hsa003801.05546112
53Maturity onset diabetes of the young_Homo sapiens_hsa049501.02227255
54cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01912965
55Dilated cardiomyopathy_Homo sapiens_hsa054140.99754326
56Huntingtons disease_Homo sapiens_hsa050160.98017212
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.96309478
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.95977926
59Propanoate metabolism_Homo sapiens_hsa006400.94919282
60Melanogenesis_Homo sapiens_hsa049160.93984652
61Axon guidance_Homo sapiens_hsa043600.93789861
62Protein export_Homo sapiens_hsa030600.93158408
63Basal transcription factors_Homo sapiens_hsa030220.91909010
64Collecting duct acid secretion_Homo sapiens_hsa049660.91166554
65Nitrogen metabolism_Homo sapiens_hsa009100.90563295
66RNA polymerase_Homo sapiens_hsa030200.90501662
67Selenocompound metabolism_Homo sapiens_hsa004500.88602853
68ABC transporters_Homo sapiens_hsa020100.87717719
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87569357
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87176190
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.86939613
72Fanconi anemia pathway_Homo sapiens_hsa034600.86786812
73Glioma_Homo sapiens_hsa052140.84952330
74Homologous recombination_Homo sapiens_hsa034400.84273692
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.83866425
76Oocyte meiosis_Homo sapiens_hsa041140.80975166
77Regulation of autophagy_Homo sapiens_hsa041400.78247833
78Bile secretion_Homo sapiens_hsa049760.77578412
79ErbB signaling pathway_Homo sapiens_hsa040120.74860490
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74058373
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72235667
82Inositol phosphate metabolism_Homo sapiens_hsa005620.71512764
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69323892
84Caffeine metabolism_Homo sapiens_hsa002320.68994614
85Choline metabolism in cancer_Homo sapiens_hsa052310.67997638
86Glycerolipid metabolism_Homo sapiens_hsa005610.67234505
87MAPK signaling pathway_Homo sapiens_hsa040100.64893723
88Peroxisome_Homo sapiens_hsa041460.64491393
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.61537978
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.60536797
91Vibrio cholerae infection_Homo sapiens_hsa051100.60054451
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59053283
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58371091
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56764306
95beta-Alanine metabolism_Homo sapiens_hsa004100.56045781
96Proteoglycans in cancer_Homo sapiens_hsa052050.54524149
97VEGF signaling pathway_Homo sapiens_hsa043700.53558811
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53105794
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52973169
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52601782
101mTOR signaling pathway_Homo sapiens_hsa041500.52456002
102RNA degradation_Homo sapiens_hsa030180.52002287
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51042663
104Chemical carcinogenesis_Homo sapiens_hsa052040.50627156
105Rap1 signaling pathway_Homo sapiens_hsa040150.50094443
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49336842
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.48835502
108Dorso-ventral axis formation_Homo sapiens_hsa043200.48192157
109Endocytosis_Homo sapiens_hsa041440.46923051
110Retinol metabolism_Homo sapiens_hsa008300.45878348
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.45096990
112Histidine metabolism_Homo sapiens_hsa003400.45012066
113Mineral absorption_Homo sapiens_hsa049780.43686569
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43420020
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43244054
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43199353
117Arachidonic acid metabolism_Homo sapiens_hsa005900.42503037
118Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41829349
119Glucagon signaling pathway_Homo sapiens_hsa049220.41602215
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39929118
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39873770
122Hedgehog signaling pathway_Homo sapiens_hsa043400.39195781
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38472003
124Renal cell carcinoma_Homo sapiens_hsa052110.38023178
125Metabolic pathways_Homo sapiens_hsa011000.37299914
126Fatty acid elongation_Homo sapiens_hsa000620.37258550
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37198615
128Focal adhesion_Homo sapiens_hsa045100.37146602
129Ovarian steroidogenesis_Homo sapiens_hsa049130.36781179
130Circadian rhythm_Homo sapiens_hsa047100.36689125
131Wnt signaling pathway_Homo sapiens_hsa043100.36505173
132Ras signaling pathway_Homo sapiens_hsa040140.35154851
133Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35117366
134Platelet activation_Homo sapiens_hsa046110.35109424
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34132637
136Amoebiasis_Homo sapiens_hsa051460.33549334
137Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33451648
138Alcoholism_Homo sapiens_hsa050340.32648057
139Endometrial cancer_Homo sapiens_hsa052130.31589261
140Purine metabolism_Homo sapiens_hsa002300.31267917
141Alzheimers disease_Homo sapiens_hsa050100.30864921
142Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30606269
143SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29177847
144Hippo signaling pathway_Homo sapiens_hsa043900.28597023
145Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28511438
146Central carbon metabolism in cancer_Homo sapiens_hsa052300.28483927

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