SLC1A7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.29950890
2photoreceptor cell differentiation (GO:0046530)6.88105794
3eye photoreceptor cell differentiation (GO:0001754)6.88105794
4L-amino acid import (GO:0043092)6.13312914
5regulation of rhodopsin mediated signaling pathway (GO:0022400)6.10291292
6surfactant homeostasis (GO:0043129)6.09480920
7rhodopsin mediated signaling pathway (GO:0016056)5.87133406
8axon ensheathment in central nervous system (GO:0032291)5.84487094
9central nervous system myelination (GO:0022010)5.84487094
10transmission of nerve impulse (GO:0019226)5.79727726
11neuron cell-cell adhesion (GO:0007158)5.75584021
12negative regulation of peptidyl-threonine phosphorylation (GO:0010801)5.45909112
13regulation of collateral sprouting (GO:0048670)5.13894247
14photoreceptor cell maintenance (GO:0045494)5.13555322
15negative regulation of axon extension (GO:0030517)4.92937978
16locomotory exploration behavior (GO:0035641)4.88121142
17myelination (GO:0042552)4.69074637
18chemical homeostasis within a tissue (GO:0048875)4.64551694
19ensheathment of neurons (GO:0007272)4.59818628
20axon ensheathment (GO:0008366)4.59818628
21neuronal ion channel clustering (GO:0045161)4.50248462
22activated T cell proliferation (GO:0050798)4.44605859
23import into cell (GO:0098657)4.41991818
24positive regulation of neurological system process (GO:0031646)4.40142829
25amino acid import (GO:0043090)4.36239738
26negative regulation of B cell mediated immunity (GO:0002713)4.31137938
27negative regulation of immunoglobulin mediated immune response (GO:0002890)4.31137938
28neuron remodeling (GO:0016322)4.18559793
29regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.15521377
30angiotensin maturation (GO:0002003)4.04994266
31cellular response to hepatocyte growth factor stimulus (GO:0035729)4.02823364
32response to hepatocyte growth factor (GO:0035728)4.02823364
33detection of light stimulus involved in visual perception (GO:0050908)4.01908335
34detection of light stimulus involved in sensory perception (GO:0050962)4.01908335
35negative regulation of axon extension involved in axon guidance (GO:0048843)3.98721926
36presynaptic membrane assembly (GO:0097105)3.95688336
37glycerophospholipid catabolic process (GO:0046475)3.94094971
38retinal cone cell development (GO:0046549)3.91479882
39negative regulation of axon guidance (GO:1902668)3.87069596
40regulation of transmission of nerve impulse (GO:0051969)3.82901941
41NADH metabolic process (GO:0006734)3.79971424
42virion attachment to host cell (GO:0019062)3.75600161
43adhesion of symbiont to host cell (GO:0044650)3.75600161
44carnitine shuttle (GO:0006853)3.70354832
45protein localization to cilium (GO:0061512)3.68435437
46regulation of extracellular matrix disassembly (GO:0010715)3.62011526
47semaphorin-plexin signaling pathway (GO:0071526)3.61995693
48regulation of axon regeneration (GO:0048679)3.61073022
49regulation of neuron projection regeneration (GO:0070570)3.61073022
50negative regulation of neurotransmitter secretion (GO:0046929)3.56752266
51single strand break repair (GO:0000012)3.53589631
52response to redox state (GO:0051775)3.48954628
53photoreceptor cell development (GO:0042461)3.48845023
54long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.45256582
55eye photoreceptor cell development (GO:0042462)3.44780977
56oligodendrocyte differentiation (GO:0048709)3.44173272
57antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.44015914
58positive regulation of gene expression, epigenetic (GO:0045815)3.43479497
59long-chain fatty acid biosynthetic process (GO:0042759)3.42706301
60Rap protein signal transduction (GO:0032486)3.40251316
61positive regulation of actin filament depolymerization (GO:0030836)3.39270923
62adhesion of symbiont to host (GO:0044406)3.36399315
63peripheral nervous system development (GO:0007422)3.34852745
64antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.33175838
65cellular response to epinephrine stimulus (GO:0071872)3.32596429
66presynaptic membrane organization (GO:0097090)3.30624487
67axonal fasciculation (GO:0007413)3.30384441
68peripheral nervous system axon ensheathment (GO:0032292)3.29904800
69myelination in peripheral nervous system (GO:0022011)3.29904800
70phototransduction (GO:0007602)3.28691291
71limb bud formation (GO:0060174)3.27024512
72negative regulation of axonogenesis (GO:0050771)3.26354742
73G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.26086791
74detection of visible light (GO:0009584)3.25763485
75phototransduction, visible light (GO:0007603)3.24806135
76negative regulation of type 2 immune response (GO:0002829)3.20410301
77detection of light stimulus (GO:0009583)3.19843537
78antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.15382797
79cellular response to nitric oxide (GO:0071732)3.13850325
80actin-myosin filament sliding (GO:0033275)3.13245569
81muscle filament sliding (GO:0030049)3.13245569
82fatty-acyl-CoA biosynthetic process (GO:0046949)3.12325612
83antigen processing and presentation of endogenous antigen (GO:0019883)3.08685323
84retina layer formation (GO:0010842)3.08139241
85peptide catabolic process (GO:0043171)3.06026536
86negative regulation of myoblast differentiation (GO:0045662)3.05437010
87fructose metabolic process (GO:0006000)3.05421121
88cellular response to reactive nitrogen species (GO:1902170)3.04470981
89substantia nigra development (GO:0021762)3.02614195
90peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.99806992
91regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.98680053
92negative regulation of cell killing (GO:0031342)2.98633656
93negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.98633656
94negative regulation of neurotransmitter transport (GO:0051589)2.97859661
95fatty acid transmembrane transport (GO:1902001)2.96994243
96very long-chain fatty acid metabolic process (GO:0000038)2.96938496
97DNA integration (GO:0015074)2.96934611
98cellular response to catecholamine stimulus (GO:0071870)2.96392457
99cellular response to monoamine stimulus (GO:0071868)2.96392457
100lipoprotein transport (GO:0042953)2.96365171
101epithelial cell differentiation involved in kidney development (GO:0035850)2.95292896
102regulation of guanylate cyclase activity (GO:0031282)2.93159070
103positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.93154726
104cell differentiation involved in metanephros development (GO:0072202)2.92272728
105negative regulation of leukocyte chemotaxis (GO:0002689)2.91053220
106response to epinephrine (GO:0071871)2.90863810
107synapse assembly (GO:0007416)2.89186098
108exploration behavior (GO:0035640)2.88106380
109actin-mediated cell contraction (GO:0070252)2.86396883
110negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.86007851
111negative regulation of complement activation (GO:0045916)2.84526278
112retinal rod cell development (GO:0046548)2.83773235
113neuron recognition (GO:0008038)2.83279535
114postsynaptic membrane organization (GO:0001941)2.82870504
115short-term memory (GO:0007614)2.82679958
116vitamin A metabolic process (GO:0006776)2.82414290
117long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.81731126
118regulation of axon guidance (GO:1902667)2.80342441
119positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.79912086
120visual perception (GO:0007601)2.78248478
121protein palmitoylation (GO:0018345)2.78208134
122negative regulation of protein localization to cell surface (GO:2000009)2.77774105
123sensory perception of light stimulus (GO:0050953)2.75834074
124peptidyl-tyrosine autophosphorylation (GO:0038083)2.75577832
125regulation of axon extension involved in axon guidance (GO:0048841)2.73103552
126neurotransmitter uptake (GO:0001504)2.72828668
127extracellular matrix assembly (GO:0085029)2.72436469
128nucleotide transmembrane transport (GO:1901679)2.70880883
129carnitine transmembrane transport (GO:1902603)2.70824883
130barbed-end actin filament capping (GO:0051016)2.70376024
131negative regulation of protein activation cascade (GO:2000258)2.70099261
132intestinal absorption (GO:0050892)2.68244101
133cGMP-mediated signaling (GO:0019934)2.64997738
134protein-lipid complex assembly (GO:0065005)2.62679431
135skeletal muscle adaptation (GO:0043501)2.60820151
136diacylglycerol metabolic process (GO:0046339)2.58589949
137glomerulus development (GO:0032835)2.58564564
138regulation of systemic arterial blood pressure by hormone (GO:0001990)2.57628487
139regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.57628487
140endocrine process (GO:0050886)2.57628487
141actin filament-based movement (GO:0030048)2.55976622
142fibril organization (GO:0097435)2.55974459
143macroautophagy (GO:0016236)2.55575658
144response to nitric oxide (GO:0071731)2.55045668
145regulation of skeletal muscle contraction (GO:0014819)2.54401688
146regulation of bile acid biosynthetic process (GO:0070857)2.54112890
147skeletal muscle contraction (GO:0003009)2.52213755
148venous blood vessel morphogenesis (GO:0048845)2.50595045
149negative regulation of fatty acid transport (GO:2000192)2.50465992
150type B pancreatic cell proliferation (GO:0044342)2.49833424
151hormone catabolic process (GO:0042447)2.48336642
152regulation of necroptotic process (GO:0060544)2.45815515
153sarcoplasmic reticulum calcium ion transport (GO:0070296)2.40754882
154fat-soluble vitamin biosynthetic process (GO:0042362)2.38792521
155negative regulation of humoral immune response (GO:0002921)2.38658793
156positive regulation of lipoprotein lipase activity (GO:0051006)2.37319165
157positive regulation of triglyceride lipase activity (GO:0061365)2.37319165
158cell migration involved in heart development (GO:0060973)2.36419982
159peptidyl-glutamic acid carboxylation (GO:0017187)2.34963131
160protein carboxylation (GO:0018214)2.34963131
161steroid hormone mediated signaling pathway (GO:0043401)2.33491378
162endocardial cushion development (GO:0003197)2.33189017
163creatine metabolic process (GO:0006600)2.32589899
164regulation of extracellular matrix organization (GO:1903053)2.31375063
165negative regulation of osteoblast differentiation (GO:0045668)2.30633476
166positive regulation of guanylate cyclase activity (GO:0031284)2.30259233
167negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.29091256
168very-low-density lipoprotein particle assembly (GO:0034379)2.28706596
169sequestering of extracellular ligand from receptor (GO:0035581)2.27269923
170response to muscle activity (GO:0014850)2.26281621
171plasma lipoprotein particle assembly (GO:0034377)2.24838977
172myofibril assembly (GO:0030239)2.24403269
173embryonic process involved in female pregnancy (GO:0060136)2.23965976
174negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.23739709
175positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.21808100
176regulation of systemic arterial blood pressure (GO:0003073)2.21075193
177regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.20908405
178positive regulation of extracellular matrix organization (GO:1903055)2.20713144
179fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.19394056
180regulation of triglyceride catabolic process (GO:0010896)2.18657246
181positive regulation of receptor recycling (GO:0001921)2.16130268
182glucan catabolic process (GO:0009251)2.16074061
183actin filament depolymerization (GO:0030042)2.15752364
184regulation of pseudopodium assembly (GO:0031272)2.15441857
185regulation of complement activation (GO:0030449)2.14282693
186retinoic acid receptor signaling pathway (GO:0048384)2.14115178
187regulation of cholesterol homeostasis (GO:2000188)2.13117924
188positive regulation of lipid catabolic process (GO:0050996)2.11110839
189negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.10823713
190protein heterotrimerization (GO:0070208)2.10713293
191positive regulation of gastrulation (GO:2000543)2.10582319
192extracellular fibril organization (GO:0043206)2.09454869
193blood vessel maturation (GO:0001955)2.08120004
194regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.07983248

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.63919478
2GBX2_23144817_ChIP-Seq_PC3_Human3.54264266
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.25702529
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.84698912
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.75976964
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.59302506
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.39853040
8DROSHA_22980978_ChIP-Seq_HELA_Human2.37139286
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.35600291
10VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.34725560
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.29296681
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.27482452
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.21494850
14SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.17760680
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.11097091
16LXR_22292898_ChIP-Seq_THP-1_Human2.00295679
17PIAS1_25552417_ChIP-Seq_VCAP_Human1.99643455
18* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.99560366
19EZH2_27294783_Chip-Seq_ESCs_Mouse1.97309217
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.95928692
21EZH2_27304074_Chip-Seq_ESCs_Mouse1.94838495
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.93616485
23EZH2_18974828_ChIP-Seq_MESCs_Mouse1.92764202
24RNF2_18974828_ChIP-Seq_MESCs_Mouse1.92764202
25MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92362921
26* SMAD3_21741376_ChIP-Seq_EPCs_Human1.92042425
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.91004444
28P300_19829295_ChIP-Seq_ESCs_Human1.88866377
29RXR_22158963_ChIP-Seq_LIVER_Mouse1.86019486
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.84820188
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78960996
32SUZ12_27294783_Chip-Seq_NPCs_Mouse1.78557935
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.78299470
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.75864076
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.74449394
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74383095
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.74201375
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.74113869
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73955065
40AR_21572438_ChIP-Seq_LNCaP_Human1.71680491
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.70301350
42TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.67255735
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.67086031
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.66544688
45EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.66390736
46SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.65379956
47NANOG_18555785_Chip-Seq_ESCs_Mouse1.64292835
48SUZ12_27294783_Chip-Seq_ESCs_Mouse1.64178563
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63185641
50PPARA_22158963_ChIP-Seq_LIVER_Mouse1.61746957
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59902074
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58022379
53SUZ12_18555785_Chip-Seq_ESCs_Mouse1.57401479
54* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.57059573
55ER_23166858_ChIP-Seq_MCF-7_Human1.56176506
56* ELK3_25401928_ChIP-Seq_HUVEC_Human1.55502962
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.55358173
58LXR_22158963_ChIP-Seq_LIVER_Mouse1.54545325
59IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.53421230
60CMYC_18555785_Chip-Seq_ESCs_Mouse1.52945217
61E2F1_18555785_Chip-Seq_ESCs_Mouse1.51222846
62VDR_22108803_ChIP-Seq_LS180_Human1.50287676
63* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.49839406
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.49690450
65P300_18555785_Chip-Seq_ESCs_Mouse1.48853272
66ESR2_21235772_ChIP-Seq_MCF-7_Human1.47362840
67TCF4_18268006_ChIP-ChIP_LS174T_Human1.45913569
68* REST_21632747_ChIP-Seq_MESCs_Mouse1.45300626
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45284625
70PRDM14_20953172_ChIP-Seq_ESCs_Human1.44707486
71FUS_26573619_Chip-Seq_HEK293_Human1.43258165
72SMAD4_21799915_ChIP-Seq_A2780_Human1.41149428
73* TBX20_22328084_ChIP-Seq_HEART_Mouse1.41059078
74* TBX20_22080862_ChIP-Seq_HEART_Mouse1.41059078
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39819045
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38731360
77RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38433532
78P53_22387025_ChIP-Seq_ESCs_Mouse1.38110044
79ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.36726101
80RACK7_27058665_Chip-Seq_MCF-7_Human1.36641575
81TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35904359
82SMAD_19615063_ChIP-ChIP_OVARY_Human1.35344211
83EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.35299206
84RUNX1_27457419_Chip-Seq_LIVER_Mouse1.34817553
85CTCF_27219007_Chip-Seq_Bcells_Human1.34099619
86HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.34077076
87TAF15_26573619_Chip-Seq_HEK293_Human1.32359758
88BCAT_22108803_ChIP-Seq_LS180_Human1.31982401
89EZH2_27294783_Chip-Seq_NPCs_Mouse1.31781595
90FLI1_27457419_Chip-Seq_LIVER_Mouse1.30852139
91NMYC_18555785_Chip-Seq_ESCs_Mouse1.30378045
92EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30222877
93* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29352982
94ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29050781
95REST_18959480_ChIP-ChIP_MESCs_Mouse1.27799547
96PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27536111
97* EP300_21415370_ChIP-Seq_HL-1_Mouse1.26919423
98STAT3_18555785_Chip-Seq_ESCs_Mouse1.26631367
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.26604963
100PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.26431334
101CLOCK_20551151_ChIP-Seq_293T_Human1.25751785
102SA1_27219007_Chip-Seq_Bcells_Human1.25746052
103KDM2B_26808549_Chip-Seq_DND41_Human1.25417108
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25334803
105KLF4_18555785_Chip-Seq_ESCs_Mouse1.25083159
106CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.24367682
107OCT4_18555785_Chip-Seq_ESCs_Mouse1.23059995
108NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.23030059
109PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22470113
110RARB_27405468_Chip-Seq_BRAIN_Mouse1.22292059
111KDM2B_26808549_Chip-Seq_K562_Human1.20907087
112PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20493038
113FOXA2_19822575_ChIP-Seq_HepG2_Human1.20462444
114SOX2_18555785_Chip-Seq_ESCs_Mouse1.19960332
115PU1_27457419_Chip-Seq_LIVER_Mouse1.19888635
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19748817
117STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19561200
118ESRRB_18555785_Chip-Seq_ESCs_Mouse1.19464597
119SMAD1_18555785_Chip-Seq_ESCs_Mouse1.19424032
120SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18177924
121FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.18058804
122ZFX_18555785_Chip-Seq_ESCs_Mouse1.17978452
123SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17939664
124NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16441954
125GATA1_26923725_Chip-Seq_HPCs_Mouse1.16066125
126TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15799268
127CDX2_20551321_ChIP-Seq_CACO-2_Human1.15173911
128GATA2_21666600_ChIP-Seq_HMVEC_Human1.14331096
129MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14274247
130UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14240644
131* TCF4_23295773_ChIP-Seq_U87_Human1.14163036
132SMAD4_21741376_ChIP-Seq_EPCs_Human1.13928611
133KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.13888017
134CJUN_26792858_Chip-Seq_BT549_Human1.13405248
135MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12541148
136RUNX2_22187159_ChIP-Seq_PCA_Human1.12397417
137BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12350101
138CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.11907995
139ERG_21242973_ChIP-ChIP_JURKAT_Human1.11847035
140CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.11613694
141SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11275032
142TP53_18474530_ChIP-ChIP_U2OS_Human1.11156365
143FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.11145062
144CBX2_27304074_Chip-Seq_ESCs_Mouse1.10110218
145* SOX2_21211035_ChIP-Seq_LN229_Gbm1.09639111
146JUN_21703547_ChIP-Seq_K562_Human1.09591834
147AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09494075
148SA1_27219007_Chip-Seq_ERYTHROID_Human1.09313977
149EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08967940
150KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08261490
151NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08102428
152CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07733155
153TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06540038
154POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06540038
155ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06337397
156TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06275831
157CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04792016
158TCF7_22412390_ChIP-Seq_EML_Mouse1.03820939
159KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00596929
160IRF8_22096565_ChIP-ChIP_GC-B_Human1.00347911
161P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99748785
162RUNX_20019798_ChIP-Seq_JUKART_Human0.98566596
163RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98499011
164GATA1_22025678_ChIP-Seq_K562_Human0.96867863
165TP63_17297297_ChIP-ChIP_HaCaT_Human0.96812544
166SMC1_22415368_ChIP-Seq_MEFs_Mouse0.96625823
167SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96495654
168* GATA1_19941827_ChIP-Seq_MEL_Mouse0.96062717
169FOXO3_23340844_ChIP-Seq_DLD1_Human0.94821939
170P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93952198
171MYC_27129775_Chip-Seq_CORNEA_Mouse0.92798610
172Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.91944019
173VDR_24763502_ChIP-Seq_THP-1_Human0.91433714
174* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91284251
175KDM2B_26808549_Chip-Seq_JURKAT_Human0.90883155
176KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90806511
177VDR_24787735_ChIP-Seq_THP-1_Human0.90379873
178STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.90299288
179RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89986238
180DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89304634
181* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89109620
182PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88509756
183CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86283450
184WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85617107
185NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.85061734
186SOX9_24532713_ChIP-Seq_HFSC_Mouse0.84840536
187NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84132235
188NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84132235
189SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.81100376

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation5.19000424
2MP0001958_emphysema4.98201389
3MP0005551_abnormal_eye_electrophysiolog4.93837115
4MP0005360_urolithiasis4.40758194
5MP0003690_abnormal_glial_cell3.45589000
6MP0006072_abnormal_retinal_apoptosis3.44737060
7MP0000920_abnormal_myelination3.32272293
8MP0005253_abnormal_eye_physiology3.31271779
9MP0005171_absent_coat_pigmentation3.22776804
10MP0005423_abnormal_somatic_nervous3.17463498
11MP0003880_abnormal_central_pattern3.11811861
12MP0003705_abnormal_hypodermis_morpholog2.91358966
13MP0000751_myopathy2.90787762
14MP0005503_abnormal_tendon_morphology2.76261983
15MP0002272_abnormal_nervous_system2.69346727
16MP0002822_catalepsy2.61062436
17MP0002064_seizures2.53916918
18MP0005248_abnormal_Harderian_gland2.50574285
19MP0001986_abnormal_taste_sensitivity2.48832480
20MP0005275_abnormal_skin_tensile2.48375897
21MP0003635_abnormal_synaptic_transmissio2.37043803
22MP0001486_abnormal_startle_reflex2.32520748
23MP0004859_abnormal_synaptic_plasticity2.29096867
24MP0005195_abnormal_posterior_eye2.24569126
25MP0004134_abnormal_chest_morphology2.22768098
26MP0001324_abnormal_eye_pigmentation2.20770897
27MP0003183_abnormal_peptide_metabolism2.20237368
28MP0002229_neurodegeneration2.18677330
29MP0004742_abnormal_vestibular_system2.16769214
30MP0001529_abnormal_vocalization2.16183242
31MP0004036_abnormal_muscle_relaxation2.12217289
32MP0003279_aneurysm2.10335071
33MP0009745_abnormal_behavioral_response2.09741583
34MP0004270_analgesia2.07030398
35MP0002090_abnormal_vision2.05915252
36MP0000566_synostosis2.05636569
37MP0004381_abnormal_hair_follicle2.00423677
38MP0005451_abnormal_body_composition1.99787820
39MP0005408_hypopigmentation1.94353544
40MP0000749_muscle_degeneration1.94074572
41MP0004885_abnormal_endolymph1.90141538
42MP0001485_abnormal_pinna_reflex1.84912994
43MP0000462_abnormal_digestive_system1.82255466
44MP0009384_cardiac_valve_regurgitation1.82117517
45MP0009840_abnormal_foam_cell1.73002315
46MP0004019_abnormal_vitamin_homeostasis1.71875040
47MP0002752_abnormal_somatic_nervous1.71708791
48MP0002736_abnormal_nociception_after1.69483743
49MP0003646_muscle_fatigue1.68802059
50MP0006054_spinal_hemorrhage1.68563434
51MP0003879_abnormal_hair_cell1.67511510
52MP0003634_abnormal_glial_cell1.67277576
53MP0003724_increased_susceptibility_to1.66696892
54MP0004272_abnormal_basement_membrane1.65862617
55MP0001968_abnormal_touch/_nociception1.61587735
56MP0000778_abnormal_nervous_system1.59229948
57MP0001905_abnormal_dopamine_level1.58867236
58MP0003806_abnormal_nucleotide_metabolis1.58354930
59MP0002882_abnormal_neuron_morphology1.55372450
60MP0002108_abnormal_muscle_morphology1.53724910
61MP0005085_abnormal_gallbladder_physiolo1.53191306
62MP0001501_abnormal_sleep_pattern1.52843720
63MP0005670_abnormal_white_adipose1.51098864
64MP0005365_abnormal_bile_salt1.50049119
65MP0002933_joint_inflammation1.49829838
66MP0008438_abnormal_cutaneous_collagen1.49818147
67MP0001177_atelectasis1.45638804
68MP0006292_abnormal_olfactory_placode1.44443866
69MP0005391_vision/eye_phenotype1.44044075
70MP0005058_abnormal_lysosome_morphology1.43046270
71MP0000759_abnormal_skeletal_muscle1.41810828
72MP0002063_abnormal_learning/memory/cond1.40085544
73MP0002067_abnormal_sensory_capabilities1.39020012
74MP0002572_abnormal_emotion/affect_behav1.38508651
75MP0005023_abnormal_wound_healing1.37431239
76MP0000747_muscle_weakness1.36121356
77MP0002295_abnormal_pulmonary_circulatio1.33364762
78MP0003632_abnormal_nervous_system1.31982028
79MP0001666_abnormal_nutrient_absorption1.30660554
80MP0001346_abnormal_lacrimal_gland1.30640845
81MP0004130_abnormal_muscle_cell1.27079490
82MP0004782_abnormal_surfactant_physiolog1.26921709
83MP0001984_abnormal_olfaction1.26797665
84MP0003436_decreased_susceptibility_to1.26314025
85MP0003191_abnormal_cellular_cholesterol1.26308241
86MP0002102_abnormal_ear_morphology1.25772579
87MP0001851_eye_inflammation1.25512550
88MP0006138_congestive_heart_failure1.23655042
89MP0001963_abnormal_hearing_physiology1.22672400
90MP0002106_abnormal_muscle_physiology1.22419720
91MP0000767_abnormal_smooth_muscle1.21961236
92MP0010329_abnormal_lipoprotein_level1.20860458
93MP0009780_abnormal_chondrocyte_physiolo1.19972220
94MP0002971_abnormal_brown_adipose1.19956826
95MP0005257_abnormal_intraocular_pressure1.19682150
96MP0001440_abnormal_grooming_behavior1.18838199
97MP0005369_muscle_phenotype1.17979311
98MP0010386_abnormal_urinary_bladder1.15377694
99MP0009046_muscle_twitch1.12964280
100MP0002998_abnormal_bone_remodeling1.12522716
101MP0004087_abnormal_muscle_fiber1.12356842
102MP0010368_abnormal_lymphatic_system1.12051488
103MP0002734_abnormal_mechanical_nocicepti1.11723296
104MP0008004_abnormal_stomach_pH1.11631572
105MP0001533_abnormal_skeleton_physiology1.11606404
106MP0005620_abnormal_muscle_contractility1.09277837
107MP0006276_abnormal_autonomic_nervous1.09074795
108MP0005075_abnormal_melanosome_morpholog1.06391541
109MP0005409_darkened_coat_color1.06109035
110MP0003300_gastrointestinal_ulcer1.06013547
111MP0001542_abnormal_bone_strength1.05874313
112MP0001727_abnormal_embryo_implantation1.04550541
113MP0004924_abnormal_behavior1.04043751
114MP0005386_behavior/neurological_phenoty1.04043751
115MP0002896_abnormal_bone_mineralization1.02170472
116MP0001664_abnormal_digestion1.02016478
117MP0000026_abnormal_inner_ear1.01893750
118MP0003172_abnormal_lysosome_physiology1.00053196
119MP0002066_abnormal_motor_capabilities/c0.99844463
120MP0002557_abnormal_social/conspecific_i0.99037021
121MP0010155_abnormal_intestine_physiology0.98232897
122MP0003136_yellow_coat_color0.97285521
123MP0005197_abnormal_uvea_morphology0.96709687
124MP0008569_lethality_at_weaning0.95318383
125MP0000013_abnormal_adipose_tissue0.95160303
126MP0003938_abnormal_ear_development0.93758021
127MP0003866_abnormal_defecation0.92089395
128MP0003950_abnormal_plasma_membrane0.92019989
129MP0000733_abnormal_muscle_development0.91692672
130MP0004084_abnormal_cardiac_muscle0.90127256
131MP0001661_extended_life_span0.90047647
132MP0002139_abnormal_hepatobiliary_system0.89694554
133MP0001502_abnormal_circadian_rhythm0.89411119
134MP0005666_abnormal_adipose_tissue0.88590086
135MP0005595_abnormal_vascular_smooth0.88385062
136MP0003091_abnormal_cell_migration0.87490212
137MP0008260_abnormal_autophagy0.86018729
138MP0000750_abnormal_muscle_regeneration0.84860270
139MP0006082_CNS_inflammation0.84826836
140MP0000955_abnormal_spinal_cord0.84101797
141MP0005390_skeleton_phenotype0.82103749
142MP0002127_abnormal_cardiovascular_syste0.81854684
143MP0002184_abnormal_innervation0.81356261
144MP0003566_abnormal_cell_adhesion0.81051778
145MP0002837_dystrophic_cardiac_calcinosis0.80467416
146MP0003631_nervous_system_phenotype0.80332891
147MP0003045_fibrosis0.80106654
148MP0000631_abnormal_neuroendocrine_gland0.77886635
149MP0000230_abnormal_systemic_arterial0.77609370
150MP0003828_pulmonary_edema0.74758907
151MP0002269_muscular_atrophy0.74100312
152MP0002234_abnormal_pharynx_morphology0.73381886
153MP0000249_abnormal_blood_vessel0.72902478
154MP0003252_abnormal_bile_duct0.72308950
155MP0002909_abnormal_adrenal_gland0.72228779
156MP0005164_abnormal_response_to0.72222003
157MP0005330_cardiomyopathy0.71566530
158MP0002118_abnormal_lipid_homeostasis0.70840652
159MP0001299_abnormal_eye_distance/0.69196327
160MP0005508_abnormal_skeleton_morphology0.69080075
161MP0004233_abnormal_muscle_weight0.68087896
162MP0004142_abnormal_muscle_tone0.67710848
163MP0002332_abnormal_exercise_endurance0.67469282
164MP0009643_abnormal_urine_homeostasis0.67009234
165MP0000383_abnormal_hair_follicle0.67001079
166MP0010030_abnormal_orbit_morphology0.66065477
167MP0003137_abnormal_impulse_conducting0.64070326
168MP0005499_abnormal_olfactory_system0.63392697
169MP0005394_taste/olfaction_phenotype0.63392697
170MP0003195_calcinosis0.62069430
171MP0002751_abnormal_autonomic_nervous0.61763028
172MP0002152_abnormal_brain_morphology0.61563492
173MP0004145_abnormal_muscle_electrophysio0.61075698
174MP0004185_abnormal_adipocyte_glucose0.61053863
175MP0003890_abnormal_embryonic-extraembry0.59823444
176MP0002638_abnormal_pupillary_reflex0.59720972
177MP0001970_abnormal_pain_threshold0.58000538
178MP0003329_amyloid_beta_deposits0.54638805
179MP0005388_respiratory_system_phenotype0.54468686
180MP0002133_abnormal_respiratory_system0.54468686
181MP0003633_abnormal_nervous_system0.52318365
182MP0002735_abnormal_chemical_nociception0.51473039
183MP0004858_abnormal_nervous_system0.49888239
184MP0000762_abnormal_tongue_morphology0.49527973

Predicted human phenotypes

RankGene SetZ-score
1Dyschromatopsia (HP:0007641)6.68210907
2Congenital stationary night blindness (HP:0007642)6.36792111
3Decreased central vision (HP:0007663)6.18806450
4Central scotoma (HP:0000603)6.01936309
5Sensory axonal neuropathy (HP:0003390)5.99465615
6Absent rod-and cone-mediated responses on ERG (HP:0007688)5.70752540
7Abnormality of macular pigmentation (HP:0008002)5.63568327
8Type 1 muscle fiber predominance (HP:0003803)5.43510670
9Subcapsular cataract (HP:0000523)5.42734117
10Abnormal rod and cone electroretinograms (HP:0008323)5.09110400
11Abolished electroretinogram (ERG) (HP:0000550)4.99870559
12Bony spicule pigmentary retinopathy (HP:0007737)4.73871718
13Nemaline bodies (HP:0003798)4.72883489
14Muscle fiber inclusion bodies (HP:0100299)4.67892616
15Degeneration of the lateral corticospinal tracts (HP:0002314)4.62407376
16Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.62407376
17Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.52718159
18Protrusio acetabuli (HP:0003179)4.46793589
19Scotoma (HP:0000575)4.45159701
20Cone-rod dystrophy (HP:0000548)4.40370449
21Premature skin wrinkling (HP:0100678)4.39964701
22Chorioretinal atrophy (HP:0000533)4.24205704
23Aortic aneurysm (HP:0004942)4.04337146
24Atonic seizures (HP:0010819)3.94158876
25Pigmentary retinal degeneration (HP:0001146)3.91687401
26Exercise-induced myalgia (HP:0003738)3.91179647
27Peripheral hypomyelination (HP:0007182)3.89462759
28Pendular nystagmus (HP:0012043)3.75800307
29Polar cataract (HP:0010696)3.74116432
30Hydroxyprolinuria (HP:0003080)3.50695679
31Abnormality of proline metabolism (HP:0010907)3.50695679
32Abnormality of glutamine family amino acid metabolism (HP:0010902)3.39313093
33Abnormality of the corticospinal tract (HP:0002492)3.38841630
34Attenuation of retinal blood vessels (HP:0007843)3.28462075
35Abnormality of skeletal muscle fiber size (HP:0012084)3.26620233
36Small epiphyses (HP:0010585)3.22625873
37Increased variability in muscle fiber diameter (HP:0003557)3.20130619
38Macular degeneration (HP:0000608)3.16360857
39Premature rupture of membranes (HP:0001788)3.15864843
40Cerebral hypomyelination (HP:0006808)3.12398181
41Systemic lupus erythematosus (HP:0002725)3.12119724
42Round ear (HP:0100830)3.10142403
43Dynein arm defect of respiratory motile cilia (HP:0012255)3.09721700
44Absent/shortened dynein arms (HP:0200106)3.09721700
45Aortic dissection (HP:0002647)3.02883299
46Increased corneal curvature (HP:0100692)3.01503349
47Keratoconus (HP:0000563)3.01503349
48Vascular tortuosity (HP:0004948)3.00053650
49Increased connective tissue (HP:0009025)2.94627791
50Myopathic facies (HP:0002058)2.91324113
51Stage 5 chronic kidney disease (HP:0003774)2.73051197
52Esophageal atresia (HP:0002032)2.71169395
53Retinal dysplasia (HP:0007973)2.67368284
54Ulnar deviation of the wrist (HP:0003049)2.66822575
55Centrally nucleated skeletal muscle fibers (HP:0003687)2.66746916
56Deep palmar crease (HP:0006191)2.64612925
57Asymmetric septal hypertrophy (HP:0001670)2.64334586
58Mildly elevated creatine phosphokinase (HP:0008180)2.63675451
59Interstitial pulmonary disease (HP:0006530)2.63419068
60Alacrima (HP:0000522)2.61311127
61Slender build (HP:0001533)2.58322004
62Distal lower limb muscle weakness (HP:0009053)2.55952717
63Photophobia (HP:0000613)2.53820613
64Arterial tortuosity (HP:0005116)2.53369533
65Morphological abnormality of the inner ear (HP:0011390)2.53206535
66Neck muscle weakness (HP:0000467)2.50125752
67Muscle fiber splitting (HP:0003555)2.49497798
68Vertebral compression fractures (HP:0002953)2.48563866
69Aplasia/Hypoplasia involving the musculature (HP:0001460)2.47385694
70Distal arthrogryposis (HP:0005684)2.46866930
71Type II diabetes mellitus (HP:0005978)2.46795620
72Urinary bladder sphincter dysfunction (HP:0002839)2.40908552
73Neonatal short-limb short stature (HP:0008921)2.40463324
74Cervical subluxation (HP:0003308)2.40290966
75Atrioventricular block (HP:0001678)2.39889536
76Peritonitis (HP:0002586)2.37614199
77Difficulty running (HP:0009046)2.36308077
78Spinal rigidity (HP:0003306)2.35916929
79Redundant skin (HP:0001582)2.33992299
80Abnormal auditory evoked potentials (HP:0006958)2.33328449
81Vitreoretinal degeneration (HP:0000655)2.31902866
82Broad metatarsal (HP:0001783)2.31194918
83Hyporeflexia of lower limbs (HP:0002600)2.28592400
84Exercise-induced muscle cramps (HP:0003710)2.26649771
85Abnormality of complement system (HP:0005339)2.26008776
86Complement deficiency (HP:0004431)2.22380351
87Thin bony cortex (HP:0002753)2.20432542
88Renal Fanconi syndrome (HP:0001994)2.20057675
89Increased hepatocellular lipid droplets (HP:0006565)2.19973087
90Retinitis pigmentosa (HP:0000510)2.19703497
91Spastic paraparesis (HP:0002313)2.17458925
92Spastic gait (HP:0002064)2.17091842
93Cerebral aneurysm (HP:0004944)2.15739251
94Muscle stiffness (HP:0003552)2.15542843
95Abnormality of the vitreous humor (HP:0004327)2.15426274
96White forelock (HP:0002211)2.14749858
97Aneurysm (HP:0002617)2.14617922
98Progressive visual loss (HP:0000529)2.14016185
99Distal lower limb amyotrophy (HP:0008944)2.11334552
100Muscle hypertrophy of the lower extremities (HP:0008968)2.09505638
101Hemorrhage of the eye (HP:0011885)2.07332719
102Dilatation of the ascending aorta (HP:0005111)2.07124710
103EMG: myopathic abnormalities (HP:0003458)2.06690717
104Hypoplasia of the capital femoral epiphysis (HP:0003090)2.06062068
105Flat face (HP:0012368)2.05231706
106Bladder diverticulum (HP:0000015)2.05139178
107Severe visual impairment (HP:0001141)2.02146210
108Cerebral palsy (HP:0100021)2.00397937
109Deep venous thrombosis (HP:0002625)1.99948268
110Patchy hypopigmentation of hair (HP:0011365)1.99765748
111Stomatitis (HP:0010280)1.99741159
112Abnormality of dentin (HP:0010299)1.99423825
113Epileptic encephalopathy (HP:0200134)1.98260221
114Malnutrition (HP:0004395)1.98155156
115Rhabdomyolysis (HP:0003201)1.97658948
116Wormian bones (HP:0002645)1.97500168
117Xanthomatosis (HP:0000991)1.97174057
118Eczematoid dermatitis (HP:0000976)1.95184351
119Abnormality of the parathyroid morphology (HP:0011766)1.95134087
120Decreased electroretinogram (ERG) amplitude (HP:0000654)1.93484322
121Abnormal ciliary motility (HP:0012262)1.90685244
122Type II lissencephaly (HP:0007260)1.90658009
123Dysmetria (HP:0001310)1.89110897
124Atrophic scars (HP:0001075)1.85819285
125Bulbar palsy (HP:0001283)1.85768277
126Megalencephaly (HP:0001355)1.85177258
127Emphysema (HP:0002097)1.84322679
128Biconcave vertebral bodies (HP:0004586)1.83887452
129Choroideremia (HP:0001139)1.83086092
130Febrile seizures (HP:0002373)1.81602255
131Soft skin (HP:0000977)1.81464594
132Ankle contracture (HP:0006466)1.80484079
133Leukodystrophy (HP:0002415)1.79342345
134Vaginal atresia (HP:0000148)1.78457966
135Decreased lacrimation (HP:0000633)1.77914229
136Parakeratosis (HP:0001036)1.77623662
137Joint stiffness (HP:0001387)1.77578477
138Optic disc pallor (HP:0000543)1.77525431
139Lipid accumulation in hepatocytes (HP:0006561)1.76174854
140Increased circulating renin level (HP:0000848)1.75855535
141Hypomagnesemia (HP:0002917)1.74994253
142Hyperuricemia (HP:0002149)1.74642407
143Increased purine levels (HP:0004368)1.74642407
144Aortic regurgitation (HP:0001659)1.74620159
145Posterior subcapsular cataract (HP:0007787)1.74221029
146Anomalous pulmonary venous return (HP:0010772)1.74099986
147Tubulointerstitial fibrosis (HP:0005576)1.73785702
148Abnormality of the calf musculature (HP:0001430)1.73572843
149Generalized myoclonic seizures (HP:0002123)1.72568880
150Nephritis (HP:0000123)1.71072027
151Hyperthyroidism (HP:0000836)1.70728779
152Absent epiphyses (HP:0010577)1.70564544
153Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.70564544
154Bowel incontinence (HP:0002607)1.70051010
155Ileus (HP:0002595)1.69432927
156Calf muscle hypertrophy (HP:0008981)1.69072639
157Abnormal pupillary function (HP:0007686)1.68330256
158Cupped ear (HP:0000378)1.68091570
159Blue sclerae (HP:0000592)1.67974127
160Spondylolisthesis (HP:0003302)1.67464868
161Stenosis of the external auditory canal (HP:0000402)1.65814479
162Septo-optic dysplasia (HP:0100842)1.65099115
163Genital tract atresia (HP:0001827)1.64646681
164Poor coordination (HP:0002370)1.64441118
165Calcaneovalgus deformity (HP:0001848)1.63811956
166Widely patent fontanelles and sutures (HP:0004492)1.63197457
167Myoglobinuria (HP:0002913)1.62674579
168Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.60899353
169Abnormality of incisor morphology (HP:0011063)1.60447652
170Gingivitis (HP:0000230)1.59782982
171Scapular winging (HP:0003691)1.59697010
172Segmental peripheral demyelination/remyelination (HP:0003481)1.59085864
173Abnormal respiratory motile cilium morphology (HP:0005938)1.58933154
174Abnormal respiratory epithelium morphology (HP:0012253)1.58933154
175Shallow orbits (HP:0000586)1.58720268
176Joint hemorrhage (HP:0005261)1.58394013
177Congenital sensorineural hearing impairment (HP:0008527)1.58242265
178Hypoalphalipoproteinemia (HP:0003233)1.57555250
179Abnormality of renal resorption (HP:0011038)1.57035976
180Broad distal phalanx of finger (HP:0009836)1.56980327
181Ovoid vertebral bodies (HP:0003300)1.56978401
182Ventricular tachycardia (HP:0004756)1.56922030
183Bradycardia (HP:0001662)1.56524600
184Constricted visual fields (HP:0001133)1.56519377
185Limited hip movement (HP:0008800)1.55310509
186Deformed tarsal bones (HP:0008119)1.54496701
187Malignant hyperthermia (HP:0002047)1.54415734
188Flared iliac wings (HP:0002869)1.53923616

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK6.00750060
2STK394.59390310
3IRAK24.01916201
4ERN14.00749326
5TTN3.55535160
6OBSCN3.33484840
7EPHA43.21173441
8IRAK13.14492291
9OXSR13.02417215
10RIPK12.98417358
11PRPF4B2.85525805
12TRIB32.40842853
13MYLK2.39619359
14IRAK42.29316845
15DDR22.12505343
16GRK12.11408968
17PDGFRA2.09709095
18FES2.09608868
19MST42.08840670
20MAP3K21.95656735
21FGFR21.95243800
22TGFBR21.93279320
23UHMK11.89290062
24SIK11.87440146
25EPHB21.83145858
26PKN11.78510235
27MAP2K31.77483120
28FGFR41.76871222
29PBK1.73258496
30CASK1.70388807
31PIK3CG1.66187036
32NEK91.62205354
33ZAP701.59702724
34DYRK1B1.57945702
35MAP3K71.54856330
36TYRO31.54483413
37MAPK131.50413397
38WNK41.49135413
39BMPR1B1.47568570
40TYK21.46549339
41FGR1.45959188
42EPHB11.45338482
43STK161.42951713
44CDC42BPA1.42713936
45PRKG21.41891401
46MAP3K61.38570733
47PRKD21.38086971
48PHKG21.36904447
49PHKG11.36904447
50MINK11.34863665
51GRK61.32822074
52MAP4K11.28801238
53MST1R1.27619858
54MARK11.23767743
55STK381.21363852
56PDGFRB1.13807104
57PTK61.13555858
58MAP3K31.11012831
59ABL21.09060004
60CDK191.08623916
61EPHA21.08387485
62ROCK21.08384843
63MARK21.08078502
64BCR1.07736763
65TESK11.06767208
66BMX1.06127153
67TNK21.04938100
68GRK71.01287453
69PTK20.99631727
70NTRK30.98170151
71PAK60.97352092
72ROCK10.97112422
73PAK30.96600982
74NTRK20.96549060
75EPHA30.92969075
76MET0.92851539
77CAMK2D0.91144883
78SGK2230.90151709
79SGK4940.90151709
80SRPK10.89956837
81TAOK20.89823527
82CHEK20.89636116
83PRKCQ0.89219510
84MAP2K70.89188923
85WNK10.89146532
86JAK10.88280551
87LATS10.87567190
88FGFR30.85400264
89KIT0.84854196
90CSK0.83841564
91CDK50.81557035
92TAOK10.79853856
93MAPK70.78302827
94KSR20.78018032
95CAMK2B0.76724202
96CAMK2A0.76340476
97MAPKAPK30.74618416
98IKBKE0.74562969
99INSR0.73527544
100MAP3K40.71396625
101PDK10.70882112
102RET0.69658897
103PRKCE0.69528010
104ADRBK10.68750153
105IRAK30.67622485
106ERBB30.67349651
107PKN20.67285334
108BMPR20.66792175
109RPS6KA20.66555328
110PIK3CA0.65935877
111MAP3K10.65716583
112YES10.64993560
113CSF1R0.64288309
114CLK10.64016727
115FYN0.62862351
116PLK20.62664415
117ACVR1B0.62474647
118PRKAA20.62240130
119ICK0.61628172
120TRPM70.60996583
121MAP3K130.59909247
122DYRK20.59298409
123GRK50.59044502
124RPS6KC10.58541642
125RPS6KL10.58541642
126PRKCG0.56874569
127LMTK20.55400923
128BTK0.55090455
129BLK0.55024274
130LYN0.54981326
131MKNK10.52865835
132MAP2K40.52511188
133PRKD10.52024625
134PAK40.51918159
135MELK0.51872735
136DAPK20.51708088
137NLK0.51661938
138MAP2K60.51609797
139LIMK10.51546024
140MAP3K110.50919978
141PRKAA10.49984006
142TESK20.49702084
143HCK0.48991195
144MTOR0.47916222
145PRKACA0.47366115
146MAPK110.46091563
147RPS6KA60.45712929
148NTRK10.45445365
149PRKCB0.45068491
150JAK20.44718742
151EEF2K0.44061694
152ERBB40.43838858
153NME10.42716686
154DMPK0.42081502
155MOS0.40536496
156PAK20.40092962
157PRKCH0.36259554
158MAPK120.36155841
159TBK10.36053803
160NEK60.33851233
161SGK10.32991429
162BRD40.32726843
163MAPKAPK50.32697837
164PRKCZ0.32368994
165PDPK10.32194913
166SRC0.31606031
167PTK2B0.29220232
168CAMK2G0.27820240
169AKT30.27618485
170RIPK40.27499844
171HIPK20.27319143
172PRKCA0.27232585
173CSNK1E0.27193867
174PRKG10.25839539
175ALK0.25731063
176PRKCD0.24462083
177IKBKB0.24176285

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047446.98347358
2Ether lipid metabolism_Homo sapiens_hsa005653.79036262
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.26533518
4Fatty acid elongation_Homo sapiens_hsa000623.15322609
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.14690702
6Vitamin B6 metabolism_Homo sapiens_hsa007502.98377399
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.74009036
8Collecting duct acid secretion_Homo sapiens_hsa049662.25410111
9Oxidative phosphorylation_Homo sapiens_hsa001902.20560009
10* Glutamatergic synapse_Homo sapiens_hsa047242.12371243
11Renin-angiotensin system_Homo sapiens_hsa046141.99096779
12Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.98942832
13Fat digestion and absorption_Homo sapiens_hsa049751.97550955
14Circadian rhythm_Homo sapiens_hsa047101.94699014
15Axon guidance_Homo sapiens_hsa043601.92903166
16Protein digestion and absorption_Homo sapiens_hsa049741.89993087
17Synaptic vesicle cycle_Homo sapiens_hsa047211.88472954
18GABAergic synapse_Homo sapiens_hsa047271.86256154
19Steroid biosynthesis_Homo sapiens_hsa001001.85849929
20Staphylococcus aureus infection_Homo sapiens_hsa051501.85141165
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.84712524
22Choline metabolism in cancer_Homo sapiens_hsa052311.83976235
23Complement and coagulation cascades_Homo sapiens_hsa046101.81360181
24Other glycan degradation_Homo sapiens_hsa005111.80551630
25Vitamin digestion and absorption_Homo sapiens_hsa049771.80402871
26Starch and sucrose metabolism_Homo sapiens_hsa005001.73892282
27PPAR signaling pathway_Homo sapiens_hsa033201.72605334
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.71357483
29Histidine metabolism_Homo sapiens_hsa003401.63949588
30Serotonergic synapse_Homo sapiens_hsa047261.62270920
31Cholinergic synapse_Homo sapiens_hsa047251.62190128
32Nicotine addiction_Homo sapiens_hsa050331.54558535
33Adipocytokine signaling pathway_Homo sapiens_hsa049201.44741422
34Phospholipase D signaling pathway_Homo sapiens_hsa040721.42750099
35Morphine addiction_Homo sapiens_hsa050321.39999918
36Vibrio cholerae infection_Homo sapiens_hsa051101.38660475
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36877460
38Glycerolipid metabolism_Homo sapiens_hsa005611.36556070
39Fructose and mannose metabolism_Homo sapiens_hsa000511.36066698
40Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.35255805
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.34578615
42Butanoate metabolism_Homo sapiens_hsa006501.33553415
43Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.29135943
44Insulin resistance_Homo sapiens_hsa049311.21040868
45Dopaminergic synapse_Homo sapiens_hsa047281.20831581
46Focal adhesion_Homo sapiens_hsa045101.20451905
47Bile secretion_Homo sapiens_hsa049761.19310119
48Galactose metabolism_Homo sapiens_hsa000521.18913878
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17923473
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.16942047
51Dilated cardiomyopathy_Homo sapiens_hsa054141.15486001
52Arginine biosynthesis_Homo sapiens_hsa002201.14016653
53Circadian entrainment_Homo sapiens_hsa047131.13604672
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12137482
55Alzheimers disease_Homo sapiens_hsa050101.09447585
56Viral myocarditis_Homo sapiens_hsa054161.09219536
57Graft-versus-host disease_Homo sapiens_hsa053321.09212140
58Leukocyte transendothelial migration_Homo sapiens_hsa046701.08728338
59Glycerophospholipid metabolism_Homo sapiens_hsa005641.08571924
60Parkinsons disease_Homo sapiens_hsa050121.08113452
61Glycosaminoglycan degradation_Homo sapiens_hsa005311.07686095
62Sulfur metabolism_Homo sapiens_hsa009201.07126197
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04332709
64Rheumatoid arthritis_Homo sapiens_hsa053230.98762768
65Long-term depression_Homo sapiens_hsa047300.93365821
66Pertussis_Homo sapiens_hsa051330.90998437
67Cardiac muscle contraction_Homo sapiens_hsa042600.90652430
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89660598
69Malaria_Homo sapiens_hsa051440.85943032
70Amoebiasis_Homo sapiens_hsa051460.85339370
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85333876
72Insulin signaling pathway_Homo sapiens_hsa049100.84866036
73Osteoclast differentiation_Homo sapiens_hsa043800.84019989
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83885999
75Non-small cell lung cancer_Homo sapiens_hsa052230.82655742
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81527496
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81204621
78Glucagon signaling pathway_Homo sapiens_hsa049220.80470986
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80152047
80Olfactory transduction_Homo sapiens_hsa047400.79296391
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79222889
82Fatty acid degradation_Homo sapiens_hsa000710.77858544
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77362542
84Pentose phosphate pathway_Homo sapiens_hsa000300.77004981
85Platelet activation_Homo sapiens_hsa046110.75952190
86Taste transduction_Homo sapiens_hsa047420.75445790
87Arginine and proline metabolism_Homo sapiens_hsa003300.73690971
88Allograft rejection_Homo sapiens_hsa053300.73250205
89AMPK signaling pathway_Homo sapiens_hsa041520.72802614
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71834977
91Arachidonic acid metabolism_Homo sapiens_hsa005900.71587248
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71496554
93Phenylalanine metabolism_Homo sapiens_hsa003600.70490246
94Leishmaniasis_Homo sapiens_hsa051400.70100671
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70042547
96Proteoglycans in cancer_Homo sapiens_hsa052050.69394813
97Sphingolipid metabolism_Homo sapiens_hsa006000.68917521
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67422896
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66391521
100Ras signaling pathway_Homo sapiens_hsa040140.65980527
101Autoimmune thyroid disease_Homo sapiens_hsa053200.64833741
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64260305
1032-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63241480
104Notch signaling pathway_Homo sapiens_hsa043300.63100178
105Retinol metabolism_Homo sapiens_hsa008300.62353024
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61324655
107Tight junction_Homo sapiens_hsa045300.61090654
108Oxytocin signaling pathway_Homo sapiens_hsa049210.60645676
109Huntingtons disease_Homo sapiens_hsa050160.59860259
110Toxoplasmosis_Homo sapiens_hsa051450.59263739
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58560074
112Acute myeloid leukemia_Homo sapiens_hsa052210.58415549
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.57791929
114Chronic myeloid leukemia_Homo sapiens_hsa052200.56826479
115Long-term potentiation_Homo sapiens_hsa047200.56725115
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56595630
117Renin secretion_Homo sapiens_hsa049240.54401090
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53524162
119Lysosome_Homo sapiens_hsa041420.51939054
120GnRH signaling pathway_Homo sapiens_hsa049120.51908918
121Salivary secretion_Homo sapiens_hsa049700.51828779
122VEGF signaling pathway_Homo sapiens_hsa043700.51788769
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51495933
124Renal cell carcinoma_Homo sapiens_hsa052110.49968826
125Endocytosis_Homo sapiens_hsa041440.48929262
126Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48262445
127ECM-receptor interaction_Homo sapiens_hsa045120.47877339
128Chemokine signaling pathway_Homo sapiens_hsa040620.47621500
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46884405
130Chemical carcinogenesis_Homo sapiens_hsa052040.46505375
131cAMP signaling pathway_Homo sapiens_hsa040240.46282206
132FoxO signaling pathway_Homo sapiens_hsa040680.46211805
133TNF signaling pathway_Homo sapiens_hsa046680.45173032
134Gastric acid secretion_Homo sapiens_hsa049710.43422402
135MAPK signaling pathway_Homo sapiens_hsa040100.43262400
136Antigen processing and presentation_Homo sapiens_hsa046120.43253693
137Hepatitis C_Homo sapiens_hsa051600.43251834
138Rap1 signaling pathway_Homo sapiens_hsa040150.41962114
139Phagosome_Homo sapiens_hsa041450.41760127
140Linoleic acid metabolism_Homo sapiens_hsa005910.41683128
141Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41380271
142Tyrosine metabolism_Homo sapiens_hsa003500.41077782
143Inositol phosphate metabolism_Homo sapiens_hsa005620.41058372
144Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40974672
145Propanoate metabolism_Homo sapiens_hsa006400.40102736
146Prion diseases_Homo sapiens_hsa050200.39713961
147Tuberculosis_Homo sapiens_hsa051520.39700608
148Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39470463
149Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37951875
150Central carbon metabolism in cancer_Homo sapiens_hsa052300.37873479
151Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37532567
152Amphetamine addiction_Homo sapiens_hsa050310.37382682
153Maturity onset diabetes of the young_Homo sapiens_hsa049500.37085190
154alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36882643
155Peroxisome_Homo sapiens_hsa041460.36821945
156Insulin secretion_Homo sapiens_hsa049110.36480210
157Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34278631
158Steroid hormone biosynthesis_Homo sapiens_hsa001400.33469459
159Vascular smooth muscle contraction_Homo sapiens_hsa042700.31867409
160Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30884658
161Cocaine addiction_Homo sapiens_hsa050300.30750841
162Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30642248
163Protein export_Homo sapiens_hsa030600.30107834
164Fatty acid metabolism_Homo sapiens_hsa012120.29742076
165Salmonella infection_Homo sapiens_hsa051320.28524274
166ABC transporters_Homo sapiens_hsa020100.27963864
167Calcium signaling pathway_Homo sapiens_hsa040200.27037421
168Metabolic pathways_Homo sapiens_hsa011000.25595362
169Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24881257
170Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24489184
171Type II diabetes mellitus_Homo sapiens_hsa049300.23071922
172Mineral absorption_Homo sapiens_hsa049780.21954380
173PI3K-Akt signaling pathway_Homo sapiens_hsa041510.20791152
174Prostate cancer_Homo sapiens_hsa052150.20471619
175Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19618434
176Gap junction_Homo sapiens_hsa045400.19334003
177Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.18449574

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