SLC20A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a sodium-phosphate symporter that absorbs phosphate from interstitial fluid for use in cellular functions such as metabolism, signal transduction, and nucleic acid and lipid synthesis. The encoded protein is also a retroviral receptor, causing human cells to be susceptible to infection by gibbon ape leukemia virus, simian sarcoma-associated virus, feline leukemia virus subgroup B, and 10A1 murine leukemia virus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)6.96513344
2protein localization to endosome (GO:0036010)4.85477872
3mesodermal cell differentiation (GO:0048333)4.69480340
4COPI coating of Golgi vesicle (GO:0048205)4.47860544
5Golgi transport vesicle coating (GO:0048200)4.47860544
6skin morphogenesis (GO:0043589)4.44832556
7nuclear pore complex assembly (GO:0051292)4.43799089
8substrate-dependent cell migration (GO:0006929)4.37825918
9nuclear pore organization (GO:0006999)4.20583995
10sodium ion export (GO:0071436)4.16556482
11hypotonic response (GO:0006971)4.07006822
12protein maturation by protein folding (GO:0022417)3.91307551
13establishment of integrated proviral latency (GO:0075713)3.87596272
14synaptic vesicle docking involved in exocytosis (GO:0016081)3.85289244
15pre-miRNA processing (GO:0031054)3.84770086
16dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.72538499
17locomotory exploration behavior (GO:0035641)3.63296283
18maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.62149619
19positive regulation of astrocyte differentiation (GO:0048711)3.60571343
20regulation of translational termination (GO:0006449)3.59770406
21cellular response to vitamin D (GO:0071305)3.56226866
22synaptic vesicle maturation (GO:0016188)3.54941634
23chondrocyte proliferation (GO:0035988)3.53359255
24regulation of short-term neuronal synaptic plasticity (GO:0048172)3.51778106
25glutamate secretion (GO:0014047)3.50031538
26cellular potassium ion homeostasis (GO:0030007)3.43587345
27mammary gland epithelial cell proliferation (GO:0033598)3.42061194
28membrane raft organization (GO:0031579)3.41105676
29ribosome assembly (GO:0042255)3.36939047
30positive regulation of fibroblast migration (GO:0010763)3.36638592
31muscle cell migration (GO:0014812)3.34962318
32pore complex assembly (GO:0046931)3.31826210
33DNA unwinding involved in DNA replication (GO:0006268)3.31681340
34regulation of gene silencing by RNA (GO:0060966)3.31469386
35regulation of posttranscriptional gene silencing (GO:0060147)3.31469386
36regulation of gene silencing by miRNA (GO:0060964)3.31469386
37regulation of clathrin-mediated endocytosis (GO:2000369)3.29311030
38negative regulation of chondrocyte differentiation (GO:0032331)3.26646300
39heterochromatin organization (GO:0070828)3.23390747
40mitotic chromosome condensation (GO:0007076)3.21912537
41cellular copper ion homeostasis (GO:0006878)3.21896522
42endothelial cell morphogenesis (GO:0001886)3.21482399
43establishment of viral latency (GO:0019043)3.20009807
44UDP-N-acetylglucosamine metabolic process (GO:0006047)3.19591669
45cytoskeletal anchoring at plasma membrane (GO:0007016)3.17414594
46protein heterotetramerization (GO:0051290)3.17245932
47protein retention in ER lumen (GO:0006621)3.16598067
48nucleotide-sugar biosynthetic process (GO:0009226)3.15668435
49regulation of translational fidelity (GO:0006450)3.11268977
50cellular response to vitamin (GO:0071295)3.08089228
51cellular protein complex localization (GO:0034629)3.07943232
52negative regulation of histone methylation (GO:0031061)3.07560214
53regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.07127461
54mitotic metaphase plate congression (GO:0007080)3.00817337
55retina vasculature morphogenesis in camera-type eye (GO:0061299)2.99309704
56alanine transport (GO:0032328)2.95888086
57adherens junction assembly (GO:0034333)2.92407802
58proline transport (GO:0015824)2.90470985
59cerebellar granule cell differentiation (GO:0021707)2.88839314
60cell migration involved in sprouting angiogenesis (GO:0002042)2.87396003
61negative regulation of DNA repair (GO:0045738)2.86802563
62regulation of centriole replication (GO:0046599)2.86499650
63response to X-ray (GO:0010165)2.86480019
64protein complex localization (GO:0031503)2.85691107
65establishment of chromosome localization (GO:0051303)2.85355556
66vocalization behavior (GO:0071625)2.85178942
67C4-dicarboxylate transport (GO:0015740)2.83464711
68membrane disassembly (GO:0030397)2.83163320
69nuclear envelope disassembly (GO:0051081)2.83163320
70type B pancreatic cell proliferation (GO:0044342)2.82440344
71barbed-end actin filament capping (GO:0051016)2.81219745
72regulation of hippo signaling (GO:0035330)2.80498079
73mitotic nuclear envelope reassembly (GO:0007084)2.79430206
74nuclear envelope reassembly (GO:0031468)2.79430206
75hepatocyte differentiation (GO:0070365)2.78767425
76mitotic nuclear envelope disassembly (GO:0007077)2.78582997
77determination of adult lifespan (GO:0008340)2.78238804
78cell adhesion mediated by integrin (GO:0033627)2.77815632
79trophoblast giant cell differentiation (GO:0060707)2.76337177
80receptor recycling (GO:0001881)2.76268811
81NLS-bearing protein import into nucleus (GO:0006607)2.76050335
82cerebellar Purkinje cell differentiation (GO:0021702)2.75582265
83establishment of nucleus localization (GO:0040023)2.75522842
84sprouting angiogenesis (GO:0002040)2.74700783
85pinocytosis (GO:0006907)2.74474001
86negative regulation of anoikis (GO:2000811)2.73309836
87neurotransmitter secretion (GO:0007269)2.72360236
88neuromuscular process controlling balance (GO:0050885)2.70431106
89regulation of tight junction assembly (GO:2000810)2.70361437
90regulation of protein polyubiquitination (GO:1902914)2.69908560
91nucleobase-containing small molecule interconversion (GO:0015949)2.69122986
92basement membrane organization (GO:0071711)2.67520473
93layer formation in cerebral cortex (GO:0021819)2.67401784
94protein hydroxylation (GO:0018126)2.67004946
95mitotic sister chromatid segregation (GO:0000070)2.65772862
96signal complex assembly (GO:0007172)2.65404088
97wound healing, spreading of epidermal cells (GO:0035313)2.65070358
98COPII vesicle coating (GO:0048208)2.64778297
99keratinocyte proliferation (GO:0043616)2.63591251
100positive regulation of synapse maturation (GO:0090129)2.63252497
101sister chromatid segregation (GO:0000819)2.61637941
102lung vasculature development (GO:0060426)2.61068884
103regulation of mitotic spindle organization (GO:0060236)2.59527714
104regulation of metalloenzyme activity (GO:0048552)2.58383793
105positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.57955638
106apoptotic cell clearance (GO:0043277)2.56216252
107positive regulation of blood vessel endothelial cell migration (GO:0043536)2.54958076
108regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.54924672
109endodermal cell differentiation (GO:0035987)2.54816828
110wound healing, spreading of cells (GO:0044319)2.54125762
111negative regulation of keratinocyte proliferation (GO:0010839)2.53914984
112protein localization to kinetochore (GO:0034501)2.53798331
113metaphase plate congression (GO:0051310)2.53619537
114negative regulation of sodium ion transport (GO:0010766)2.51377922
115regulation of integrin activation (GO:0033623)2.51033875
116cortical actin cytoskeleton organization (GO:0030866)2.51016674
117notochord development (GO:0030903)2.50637430
118gamma-aminobutyric acid transport (GO:0015812)2.49162630
119negative regulation of hormone biosynthetic process (GO:0032353)2.49058349
120negative regulation of hormone metabolic process (GO:0032351)2.49058349
121ionotropic glutamate receptor signaling pathway (GO:0035235)2.48878207
122cell-substrate adherens junction assembly (GO:0007045)2.48474634
123focal adhesion assembly (GO:0048041)2.48474634
124fibrinolysis (GO:0042730)2.47290142
125mitotic sister chromatid cohesion (GO:0007064)2.46682435
126membrane protein ectodomain proteolysis (GO:0006509)2.46612399
127desmosome organization (GO:0002934)2.46129911
128positive regulation of p38MAPK cascade (GO:1900745)2.45194589
129heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.43732795
130positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.43572036
131L-amino acid import (GO:0043092)2.43385545
132negative regulation of fibroblast apoptotic process (GO:2000270)2.43066205
133nodal signaling pathway (GO:0038092)2.42775844
134ventricular cardiac muscle cell development (GO:0055015)2.42431824
135trophectodermal cell differentiation (GO:0001829)2.42000089
136cortical cytoskeleton organization (GO:0030865)2.41924599
137lipopolysaccharide biosynthetic process (GO:0009103)2.41309331
138stress fiber assembly (GO:0043149)2.41267290
139regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.41120345
140histone H4-K5 acetylation (GO:0043981)2.41039933
141histone H4-K8 acetylation (GO:0043982)2.41039933
142amino acid import (GO:0043090)2.40754098
143collagen metabolic process (GO:0032963)2.39820165
144protein localization to chromosome, centromeric region (GO:0071459)2.39498420
145endoplasmic reticulum unfolded protein response (GO:0030968)2.39349465
146iron ion import (GO:0097286)2.39304485
147cell-substrate junction assembly (GO:0007044)2.39300776
148positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.38876202
149epithelial cell-cell adhesion (GO:0090136)2.38772378
150mitotic cytokinesis (GO:0000281)2.38711763
151interferon-gamma secretion (GO:0072643)2.38126781
152negative regulation of organelle assembly (GO:1902116)2.38117404
153embryonic process involved in female pregnancy (GO:0060136)2.38006027
154regulation of NFAT protein import into nucleus (GO:0051532)2.37195988
155vesicle coating (GO:0006901)2.36943804
156regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.36677383
157regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.35672112
158regulation of anoikis (GO:2000209)2.35561124
159positive regulation of SMAD protein import into nucleus (GO:0060391)2.33680892
160response to epidermal growth factor (GO:0070849)2.33187455
161negative regulation of homotypic cell-cell adhesion (GO:0034111)2.32875377
162regulation of spindle organization (GO:0090224)2.32741821
163negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.31653765
164cell aggregation (GO:0098743)2.31404047
165cartilage condensation (GO:0001502)2.31404047
166folic acid-containing compound biosynthetic process (GO:0009396)2.30107648
167anterior/posterior axis specification, embryo (GO:0008595)2.30007081
168regulation of glutamate receptor signaling pathway (GO:1900449)2.28966029
169vesicle transport along microtubule (GO:0047496)2.28209006
170actin filament bundle assembly (GO:0051017)2.28150182
171actin filament bundle organization (GO:0061572)2.28150182
172regulation of RNA export from nucleus (GO:0046831)2.27466154
173DNA replication-dependent nucleosome assembly (GO:0006335)2.27462781
174DNA replication-dependent nucleosome organization (GO:0034723)2.27462781
175spliceosomal tri-snRNP complex assembly (GO:0000244)2.25563493
176positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.25166351
177regulation of histone H3-K27 methylation (GO:0061085)2.24658488
178response to histamine (GO:0034776)2.24288349
179regulation of G0 to G1 transition (GO:0070316)2.24127604
180regulation of nucleobase-containing compound transport (GO:0032239)2.21943864

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.36443025
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.22622892
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.86107983
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.80994915
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.72266254
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.28941932
7NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.75527040
8ESR1_15608294_ChIP-ChIP_MCF-7_Human2.74400667
9* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.69633875
10* SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.61206278
11SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.53107156
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.50621839
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.45318286
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.44298407
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.40604208
16POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.39987681
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.30785076
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.15465949
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.13783573
20* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.12626653
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.12440209
22* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.11854238
23* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.04158429
24ZFP281_18757296_ChIP-ChIP_E14_Mouse1.95981255
25HIF1A_21447827_ChIP-Seq_MCF-7_Human1.93184563
26ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.92956451
27* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.92831853
28ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.91098244
29MYC_22102868_ChIP-Seq_BL_Human1.82629429
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.80137569
31* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.71945395
32* UBF1/2_26484160_Chip-Seq_HMECs_Human1.69916425
33* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.68788031
34WT1_19549856_ChIP-ChIP_CCG9911_Human1.67657244
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.64288637
36* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.63143901
37TCF3_18692474_ChIP-Seq_MEFs_Mouse1.63136318
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.62777616
39WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.62430776
40TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.60317826
41* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.60154144
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59521669
43NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.59120532
44* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.58530001
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.57121805
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57058022
47KDM2B_26808549_Chip-Seq_K562_Human1.56678995
48* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.56322373
49ZNF263_19887448_ChIP-Seq_K562_Human1.55850505
50TP53_16413492_ChIP-PET_HCT116_Human1.53981136
51MYB_21317192_ChIP-Seq_ERMYB_Mouse1.49833992
52KDM2B_26808549_Chip-Seq_DND41_Human1.48755179
53* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.48647033
54HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.48426806
55STAT3_1855785_ChIP-Seq_MESCs_Mouse1.47124243
56* RARB_27405468_Chip-Seq_BRAIN_Mouse1.46522722
57TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46402994
58DCP1A_22483619_ChIP-Seq_HELA_Human1.45995754
59JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45750240
60* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45502526
61TCF3_18692474_ChIP-Seq_MESCs_Mouse1.44929417
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42949932
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39415129
64CLOCK_20551151_ChIP-Seq_293T_Human1.37646854
65CREB1_15753290_ChIP-ChIP_HEK293T_Human1.37373629
66FOXO3_23340844_ChIP-Seq_DLD1_Human1.37371286
67ATF3_27146783_Chip-Seq_COLON_Human1.36161832
68P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35721412
69PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.35577179
70POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.35158011
71* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.35038036
72* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.34917487
73SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.33717802
74* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.33392927
75HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.32693539
76AR_21909140_ChIP-Seq_LNCAP_Human1.32679966
77ESR2_21235772_ChIP-Seq_MCF-7_Human1.31764643
78RARG_19884340_ChIP-ChIP_MEFs_Mouse1.31446683
79GATA2_21666600_ChIP-Seq_HMVEC_Human1.30757250
80* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29784301
81TFEB_21752829_ChIP-Seq_HELA_Human1.29130537
82CJUN_26792858_Chip-Seq_BT549_Human1.28835193
83* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.27729375
84* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27262314
85* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27227931
86* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27050126
87* TCF7_22412390_ChIP-Seq_EML_Mouse1.26949059
88TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26775659
89ELK1_19687146_ChIP-ChIP_HELA_Human1.25760547
90* E2F1_21310950_ChIP-Seq_MCF-7_Human1.25603512
91KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.25573347
92KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.25573347
93KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.25573347
94RXR_22108803_ChIP-Seq_LS180_Human1.24692725
95MYC_19079543_ChIP-ChIP_MESCs_Mouse1.24454956
96ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23344727
97DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.21954345
98NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.20650965
99SALL4_18804426_ChIP-ChIP_XEN_Mouse1.19434056
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.18710954
101TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.18484909
102CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.17667363
103TP53_22127205_ChIP-Seq_IMR90_Human1.17182353
104POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17155064
105TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16908135
106EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15683691
107KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.15577690
108EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.14243204
109* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.12843324
110* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.12843324
111* SOX17_20123909_ChIP-Seq_XEN_Mouse1.12104895
112* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11581375
113HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11114401
114KDM2B_26808549_Chip-Seq_JURKAT_Human1.09897144
115ELK1_22589737_ChIP-Seq_MCF10A_Human1.09265621
116DROSHA_22980978_ChIP-Seq_HELA_Human1.08905553
117* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08774625
118BRD4_25478319_ChIP-Seq_HGPS_Human1.08355922
119ELK3_25401928_ChIP-Seq_HUVEC_Human1.07681720
120UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05106040
121RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04617387
122ESR1_21235772_ChIP-Seq_MCF-7_Human1.04591232
123SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04407175
124NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04258166
125POU5F1_16518401_ChIP-PET_MESCs_Mouse1.03823045
126* NANOG_16518401_ChIP-PET_MESCs_Mouse1.02850986
127MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02471117
128FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.01596686
129IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01564683
130NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01497477
131CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00974062
132AR_21572438_ChIP-Seq_LNCaP_Human1.00564104
133RACK7_27058665_Chip-Seq_MCF-7_Human1.00438285
134EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99992857
135ERG_21242973_ChIP-ChIP_JURKAT_Human0.99663272
136* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99249246
137NANOG_21062744_ChIP-ChIP_HESCs_Human0.98988852
138KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97500256
139KLF5_25053715_ChIP-Seq_YYC3_Human0.96839719
140TBX3_20139965_ChIP-Seq_ESCs_Mouse0.96757530
141PKCTHETA_26484144_Chip-Seq_BREAST_Human0.95426285
142NANOG_18692474_ChIP-Seq_MESCs_Mouse0.94212552
143* NCOR1_26117541_ChIP-Seq_K562_Human0.93825025
144MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.93019761
145TBX3_20139965_ChIP-Seq_MESCs_Mouse0.92587620
146ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92522592
147DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92337540
148GABP_17652178_ChIP-ChIP_JURKAT_Human0.92136375
149FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92134045
150* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91651206
151KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90340106
152CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90312910
153CHD1_26751641_Chip-Seq_LNCaP_Human0.90246213
154* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87964826
155PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87949491

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010352_gastrointestinal_tract_polyps4.38690314
2MP0004859_abnormal_synaptic_plasticity4.24697607
3MP0003705_abnormal_hypodermis_morpholog4.06586560
4MP0004272_abnormal_basement_membrane4.01895719
5MP0003283_abnormal_digestive_organ3.38848034
6MP0003950_abnormal_plasma_membrane2.92015908
7MP0003566_abnormal_cell_adhesion2.66523210
8MP0005623_abnormal_meninges_morphology2.64461298
9MP0000569_abnormal_digit_pigmentation2.61193982
10MP0006054_spinal_hemorrhage2.51592511
11MP0003111_abnormal_nucleus_morphology2.48020698
12MP0005076_abnormal_cell_differentiation2.47151007
13MP0005257_abnormal_intraocular_pressure2.43822315
14MP0010368_abnormal_lymphatic_system2.34182255
15MP0003941_abnormal_skin_development2.33702917
16MP0010307_abnormal_tumor_latency2.30539670
17MP0002060_abnormal_skin_morphology2.20603665
18MP0003091_abnormal_cell_migration2.20062208
19MP0009046_muscle_twitch2.11172487
20MP0010030_abnormal_orbit_morphology2.02002066
21MP0010234_abnormal_vibrissa_follicle1.89880573
22MP0000579_abnormal_nail_morphology1.87170705
23MP0003635_abnormal_synaptic_transmissio1.85774331
24MP0003279_aneurysm1.80514595
25MP0005023_abnormal_wound_healing1.75873012
26MP0002653_abnormal_ependyma_morphology1.68848803
27MP0001440_abnormal_grooming_behavior1.66951534
28MP0000762_abnormal_tongue_morphology1.64713964
29MP0005451_abnormal_body_composition1.61287810
30MP0003787_abnormal_imprinting1.58571507
31MP0002822_catalepsy1.56225824
32MP0003890_abnormal_embryonic-extraembry1.55746388
33MP0010094_abnormal_chromosome_stability1.55198941
34MP0008932_abnormal_embryonic_tissue1.53775390
35MP0001730_embryonic_growth_arrest1.52103882
36* MP0000350_abnormal_cell_proliferation1.50754709
37MP0008260_abnormal_autophagy1.50473351
38MP0009780_abnormal_chondrocyte_physiolo1.50079958
39MP0005275_abnormal_skin_tensile1.49883965
40MP0002063_abnormal_learning/memory/cond1.48983982
41MP0004270_analgesia1.48340654
42MP0004957_abnormal_blastocyst_morpholog1.47792389
43* MP0002086_abnormal_extraembryonic_tissu1.47009017
44MP0003191_abnormal_cellular_cholesterol1.43123868
45MP0004264_abnormal_extraembryonic_tissu1.42824778
46MP0003077_abnormal_cell_cycle1.40454007
47MP0000537_abnormal_urethra_morphology1.40416283
48MP0002089_abnormal_postnatal_growth/wei1.40227397
49MP0009840_abnormal_foam_cell1.38356245
50MP0003828_pulmonary_edema1.37229817
51MP0004197_abnormal_fetal_growth/weight/1.36906721
52MP0009745_abnormal_behavioral_response1.35829283
53MP0005197_abnormal_uvea_morphology1.35300218
54* MP0005380_embryogenesis_phenotype1.31462640
55* MP0001672_abnormal_embryogenesis/_devel1.31462640
56MP0002254_reproductive_system_inflammat1.31265087
57MP0005165_increased_susceptibility_to1.30906148
58MP0003123_paternal_imprinting1.30010708
59MP0001299_abnormal_eye_distance/1.28814501
60MP0003878_abnormal_ear_physiology1.27497233
61MP0005377_hearing/vestibular/ear_phenot1.27497233
62MP0005164_abnormal_response_to1.27475054
63MP0002064_seizures1.26288521
64MP0004858_abnormal_nervous_system1.26071772
65MP0002084_abnormal_developmental_patter1.24738373
66MP0001542_abnormal_bone_strength1.23979654
67MP0003172_abnormal_lysosome_physiology1.23833818
68MP0002877_abnormal_melanocyte_morpholog1.22845087
69* MP0003984_embryonic_growth_retardation1.22345261
70MP0000767_abnormal_smooth_muscle1.21684359
71* MP0002088_abnormal_embryonic_growth/wei1.19164893
72MP0004233_abnormal_muscle_weight1.18125100
73MP0001216_abnormal_epidermal_layer1.17869911
74MP0001849_ear_inflammation1.17472183
75MP0003786_premature_aging1.15811009
76MP0005621_abnormal_cell_physiology1.15648533
77MP0008438_abnormal_cutaneous_collagen1.15428683
78MP0003453_abnormal_keratinocyte_physiol1.14943986
79MP0009697_abnormal_copulation1.14182000
80MP0003045_fibrosis1.14165088
81MP0008569_lethality_at_weaning1.12524614
82MP0005501_abnormal_skin_physiology1.12383800
83MP0000627_abnormal_mammary_gland1.12179293
84MP0008007_abnormal_cellular_replicative1.11412107
85* MP0002896_abnormal_bone_mineralization1.10628751
86* MP0008770_decreased_survivor_rate1.10398386
87MP0001348_abnormal_lacrimal_gland1.10335534
88MP0001697_abnormal_embryo_size1.09500753
89MP0003632_abnormal_nervous_system1.09032162
90MP0003693_abnormal_embryo_hatching1.08701322
91MP0004808_abnormal_hematopoietic_stem1.08494984
92MP0001879_abnormal_lymphatic_vessel1.08454461
93MP0000858_altered_metastatic_potential1.07595501
94MP0008961_abnormal_basal_metabolism1.04179226
95MP0002085_abnormal_embryonic_tissue1.04111727
96MP0004811_abnormal_neuron_physiology1.03894319
97MP0002572_abnormal_emotion/affect_behav1.03088842
98MP0003656_abnormal_erythrocyte_physiolo1.01912553
99MP0000467_abnormal_esophagus_morphology1.00949813
100MP0000534_abnormal_ureter_morphology1.00520476
101MP0000751_myopathy1.00167890
102* MP0002080_prenatal_lethality0.99007363
103MP0001501_abnormal_sleep_pattern0.98437442
104MP0005167_abnormal_blood-brain_barrier0.97736860
105MP0003315_abnormal_perineum_morphology0.96913576
106MP0003448_altered_tumor_morphology0.95053791
107MP0003303_peritoneal_inflammation0.94248250
108MP0002734_abnormal_mechanical_nocicepti0.93998477
109MP0000358_abnormal_cell_content/0.90634056
110MP0002796_impaired_skin_barrier0.90034566
111MP0002736_abnormal_nociception_after0.89550564
112MP0003329_amyloid_beta_deposits0.89354537
113MP0009053_abnormal_anal_canal0.88840122
114MP0000733_abnormal_muscle_development0.88407698
115MP0005409_darkened_coat_color0.87437319
116MP0001915_intracranial_hemorrhage0.86017049
117MP0004885_abnormal_endolymph0.85035525
118MP0001968_abnormal_touch/_nociception0.84080343
119MP0005384_cellular_phenotype0.83182361
120MP0010771_integument_phenotype0.82780138
121MP0000428_abnormal_craniofacial_morphol0.82483961
122MP0004084_abnormal_cardiac_muscle0.80978221
123MP0003755_abnormal_palate_morphology0.80194909
124* MP0001614_abnormal_blood_vessel0.79749285
125MP0003300_gastrointestinal_ulcer0.79610996
126MP0001243_abnormal_dermal_layer0.79523959
127MP0000432_abnormal_head_morphology0.79213656
128MP0001958_emphysema0.79028359
129MP0005508_abnormal_skeleton_morphology0.78410667
130MP0000003_abnormal_adipose_tissue0.77296088
131MP0002152_abnormal_brain_morphology0.76061923
132MP0008058_abnormal_DNA_repair0.75080693
133* MP0002925_abnormal_cardiovascular_devel0.75023469
134MP0005408_hypopigmentation0.74707235
135MP0001881_abnormal_mammary_gland0.74053217
136MP0009384_cardiac_valve_regurgitation0.72582077
137MP0002111_abnormal_tail_morphology0.72232169
138MP0008872_abnormal_physiological_respon0.72142224
139MP0002168_other_aberrant_phenotype0.72008731
140MP0003075_altered_response_to0.71486362
141MP0003861_abnormal_nervous_system0.71331357
142MP0009672_abnormal_birth_weight0.70705311
143MP0003115_abnormal_respiratory_system0.70702649
144MP0000490_abnormal_crypts_of0.69733975
145MP0004947_skin_inflammation0.69714564
146MP0005503_abnormal_tendon_morphology0.68750747
147MP0009278_abnormal_bone_marrow0.68745163
148MP0003121_genomic_imprinting0.68469188
149MP0000604_amyloidosis0.68202692
150MP0005166_decreased_susceptibility_to0.66320075
151MP0003631_nervous_system_phenotype0.65205181

Predicted human phenotypes

RankGene SetZ-score
1Osteolytic defects of the hand bones (HP:0009699)3.64036339
2Osteolytic defects of the phalanges of the hand (HP:0009771)3.64036339
3Milia (HP:0001056)3.43913283
4Vertebral compression fractures (HP:0002953)3.40661026
5Neonatal short-limb short stature (HP:0008921)3.40058687
6Onycholysis (HP:0001806)3.36651857
7Arterial tortuosity (HP:0005116)3.28728183
8Ankle contracture (HP:0006466)3.19356482
9Short nail (HP:0001799)3.15254992
10Fragile nails (HP:0001808)3.14678112
11Follicular hyperkeratosis (HP:0007502)3.05500904
12Vascular tortuosity (HP:0004948)3.03491053
13Fragile skin (HP:0001030)2.97489593
14Upper limb muscle weakness (HP:0003484)2.94638923
15Natal tooth (HP:0000695)2.88662904
16Myocardial infarction (HP:0001658)2.84327167
17Spinal cord lesions (HP:0100561)2.75715203
18Syringomyelia (HP:0003396)2.75715203
19Abnormality of the distal phalanges of the toes (HP:0010182)2.74174808
20Spinal rigidity (HP:0003306)2.73285149
21Abnormality of the proximal phalanges of the hand (HP:0009834)2.71904166
22Reduced subcutaneous adipose tissue (HP:0003758)2.70028981
23Cardiovascular calcification (HP:0011915)2.69535594
24Entropion (HP:0000621)2.67871605
25Aortic dissection (HP:0002647)2.62050573
26Abnormality of the lower motor neuron (HP:0002366)2.60718537
27Achilles tendon contracture (HP:0001771)2.60320919
28Epiphyseal dysplasia (HP:0002656)2.57881648
29Wormian bones (HP:0002645)2.57069662
30Genu recurvatum (HP:0002816)2.56208803
31Relative macrocephaly (HP:0004482)2.54947638
32Flat acetabular roof (HP:0003180)2.54149841
33Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.52942896
34Insomnia (HP:0100785)2.52589727
35Elbow flexion contracture (HP:0002987)2.50864395
36Vascular calcification (HP:0004934)2.48405093
37Hemiplegia (HP:0002301)2.46655128
38Cervical subluxation (HP:0003308)2.44556963
39Ependymoma (HP:0002888)2.44029739
40Absent frontal sinuses (HP:0002688)2.43444424
41Shallow orbits (HP:0000586)2.42730796
42Focal seizures (HP:0007359)2.41598150
43Radial bowing (HP:0002986)2.41359236
44Abnormality of the distal phalanx of the thumb (HP:0009617)2.41119126
45Diplopia (HP:0000651)2.41012297
46Abnormality of binocular vision (HP:0011514)2.41012297
47Irregular epiphyses (HP:0010582)2.39820984
48Abnormality of the astrocytes (HP:0100707)2.38878533
49Astrocytoma (HP:0009592)2.38878533
50Distal upper limb amyotrophy (HP:0007149)2.36833616
51Upper limb amyotrophy (HP:0009129)2.36833616
52Ulnar bowing (HP:0003031)2.33354497
53Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.31412595
54Vertebral hypoplasia (HP:0008417)2.31412595
55Nail dystrophy (HP:0008404)2.30019101
56Protrusio acetabuli (HP:0003179)2.28770713
57Mild short stature (HP:0003502)2.27849666
58Hand muscle atrophy (HP:0009130)2.27315019
59Abnormality of the umbilical cord (HP:0010881)2.27200365
60Abnormality of carpal bone ossification (HP:0006257)2.26475007
61Abnormality of the labia minora (HP:0012880)2.23654625
62Thick nail (HP:0001805)2.23635161
63Lower limb amyotrophy (HP:0007210)2.22824900
64Abnormality of the Achilles tendon (HP:0005109)2.21652974
65Increased connective tissue (HP:0009025)2.20526853
66Abnormal vertebral ossification (HP:0100569)2.19147175
67Heterotopia (HP:0002282)2.19018344
68Premature rupture of membranes (HP:0001788)2.18488678
69Broad palm (HP:0001169)2.18035597
70Pterygium (HP:0001059)2.17589247
71Dilatation of the ascending aorta (HP:0005111)2.17441571
72Generalized amyotrophy (HP:0003700)2.17004611
73Bladder diverticulum (HP:0000015)2.15780292
74Cerebral aneurysm (HP:0004944)2.13660999
75Hyperacusis (HP:0010780)2.13446475
76Cupped ribs (HP:0000887)2.11729897
77Impaired smooth pursuit (HP:0007772)2.10584359
78Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.10399835
79Dysmetric saccades (HP:0000641)2.09010553
80Hypoplasia of the capital femoral epiphysis (HP:0003090)2.08569754
81Limited elbow extension (HP:0001377)2.07467779
82Spondylolisthesis (HP:0003302)2.06041414
83Renal duplication (HP:0000075)2.04156937
84Blue sclerae (HP:0000592)2.03874118
85Small epiphyses (HP:0010585)2.03606823
86Broad thumb (HP:0011304)2.02707944
87Distal lower limb muscle weakness (HP:0009053)2.00735356
88Abnormality of dentin (HP:0010299)1.99771810
89Distal lower limb amyotrophy (HP:0008944)1.98821519
90Abnormal ossification of hand bones (HP:0005921)1.98450646
91Abnormality of oral frenula (HP:0000190)1.98319497
92Spinal cord compression (HP:0002176)1.98081521
93Epileptic encephalopathy (HP:0200134)1.96388466
94Microglossia (HP:0000171)1.96353821
95Rough bone trabeculation (HP:0100670)1.95315088
96Vertebral clefting (HP:0008428)1.94713847
97Aortic aneurysm (HP:0004942)1.94564432
98Insidious onset (HP:0003587)1.92683186
99Termporal pattern (HP:0011008)1.92683186
100Abnormalities of placenta or umbilical cord (HP:0001194)1.92585655
101Flat capital femoral epiphysis (HP:0003370)1.92312489
102Hypoplastic ischia (HP:0003175)1.90889919
103Limb-girdle muscle atrophy (HP:0003797)1.90071152
104Abnormality of the acetabulum (HP:0003170)1.90030242
105Pointed chin (HP:0000307)1.89953638
106Aplasia involving bones of the extremities (HP:0009825)1.89916191
107Aplasia involving bones of the upper limbs (HP:0009823)1.89916191
108Aplasia of the phalanges of the hand (HP:0009802)1.89916191
109Abnormality of ocular smooth pursuit (HP:0000617)1.88753638
110Focal motor seizures (HP:0011153)1.88406814
111Plantar hyperkeratosis (HP:0007556)1.87434364
112Arnold-Chiari malformation (HP:0002308)1.86893892
113Protruding ear (HP:0000411)1.86056080
114Tetraparesis (HP:0002273)1.84979317
115Deviation of the thumb (HP:0009603)1.84612731
116Reticulocytosis (HP:0001923)1.84601662
117Selective tooth agenesis (HP:0001592)1.84467884
118Atrophic scars (HP:0001075)1.84351147
119Aplasia cutis congenita (HP:0001057)1.83170758
120Glucose intolerance (HP:0000833)1.83012574
121Broad long bones (HP:0005622)1.81390101
122Metaphyseal cupping (HP:0003021)1.80260651
123Flattened epiphyses (HP:0003071)1.80221827
124Glioma (HP:0009733)1.79144491
125Coxa vara (HP:0002812)1.79017185
126Short clavicles (HP:0000894)1.78858311
127Mildly elevated creatine phosphokinase (HP:0008180)1.78536744
128Disproportionate tall stature (HP:0001519)1.78272126
129Trismus (HP:0000211)1.77230840
130Abnormality of the 1st metacarpal (HP:0010009)1.76916919
131Hypoplastic toenails (HP:0001800)1.76640060
132Status epilepticus (HP:0002133)1.76245306
133Abnormality of the epiphyses of the hand (HP:0005924)1.75881224
134Broad phalanges of the hand (HP:0009768)1.75693905
135Ankyloglossia (HP:0010296)1.75481415
136Mitral valve prolapse (HP:0001634)1.75353725
137Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.75048001
138Ridged nail (HP:0001807)1.74887871
139Short humerus (HP:0005792)1.74716284
140Slender build (HP:0001533)1.74440073
141Vitreoretinal degeneration (HP:0000655)1.73028560
142Broad phalanx (HP:0006009)1.72808516
143Soft skin (HP:0000977)1.71882599
144Nuclear cataract (HP:0100018)1.71709016
145Abnormal umbilical cord blood vessels (HP:0011403)1.70836707
146Single umbilical artery (HP:0001195)1.70836707
147Abnormality of the fetal cardiovascular system (HP:0010948)1.70836707
148Febrile seizures (HP:0002373)1.70042192
149Abnormal auditory evoked potentials (HP:0006958)1.69611591
150Stillbirth (HP:0003826)1.68890703
151Joint laxity (HP:0001388)1.68700356
152Broad face (HP:0000283)1.68346410
153Bowel diverticulosis (HP:0005222)1.66373532
154Short middle phalanx of finger (HP:0005819)1.66160045
155Hemiparesis (HP:0001269)1.65719515
156Broad finger (HP:0001500)1.65661833
157Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.64757472
158Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.64480603
159Gastrointestinal carcinoma (HP:0002672)1.62598305
160Malignant gastrointestinal tract tumors (HP:0006749)1.62598305
161Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.61303351
162Trigonocephaly (HP:0000243)1.60637641
163Short 4th metacarpal (HP:0010044)1.60448453
164Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.60448453
165Abnormality of the nasal septum (HP:0000419)1.58800957
166Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.58408141
167Impaired social interactions (HP:0000735)1.58313221
168Abnormal social behavior (HP:0012433)1.58313221
169Impaired vibration sensation in the lower limbs (HP:0002166)1.58135539
170Fibular aplasia (HP:0002990)1.56959840
171Mesomelia (HP:0003027)1.56019621
172Sandal gap (HP:0001852)1.55731228
173Scanning speech (HP:0002168)1.55655562
174Abnormality of the calcaneus (HP:0008364)1.54876515
175Pseudobulbar signs (HP:0002200)1.54612516
176Long palpebral fissure (HP:0000637)1.54334684
177Short phalanx of the thumb (HP:0009660)1.53925161

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.14724912
2NME23.41596767
3CDK123.18765547
4MST1R3.18500952
5LMTK23.11562314
6BUB12.54286163
7MET2.44649700
8MAP3K92.44180190
9DDR22.26857580
10NEK12.26510242
11TYRO32.05653091
12CDC72.03126976
13IRAK31.99325683
14MOS1.96404497
15RIPK11.90965969
16NTRK31.90920178
17SIK31.87762862
18ALK1.85464704
19TGFBR21.84029295
20LIMK11.80620578
21PNCK1.79541850
22BMX1.78362675
23SCYL21.76192168
24DAPK21.70534125
25PDGFRA1.66476162
26MAP3K41.65253518
27EPHA41.64914141
28TESK11.63576251
29LATS21.59812707
30ARAF1.55578685
31MAP3K131.54912334
32EPHB11.53952171
33STK101.45928536
34TSSK61.43776594
35TRIM281.42971296
36EPHB21.42693048
37CAMKK11.39244923
38BRD41.38074308
39SGK31.35646315
40PKN21.33632357
41PBK1.32285212
42FLT31.31452317
43ERN11.29742151
44TAOK11.28914125
45SIK21.25141258
46TTN1.23607191
47KSR11.23386583
48PAK61.23217436
49NTRK21.18787659
50PTK21.18348058
51ICK1.18087637
52PIM21.17740432
53KSR21.17280886
54TRIB31.17246426
55SMG11.16153518
56STK381.14049235
57BRSK21.12178369
58SGK21.12053076
59FGFR11.11208263
60PLK21.10492867
61EIF2AK31.06203319
62MINK11.05575237
63SIK11.01774203
64MST41.01002629
65TTK0.99145145
66SRPK10.99070122
67PLK40.91504583
68MAP3K120.90616390
69GRK60.89045766
70EEF2K0.86274438
71ROCK20.85430127
72DAPK10.84152367
73BCR0.83955033
74BRSK10.82458781
75TESK20.80442672
76NEK20.78926785
77MTOR0.77685365
78FGFR30.77349448
79PTK60.76784959
80LATS10.75866141
81RET0.75779051
82MAP3K80.75193542
83PRPF4B0.74015614
84PLK30.72718490
85CDC42BPA0.72438032
86PAK40.72139130
87MELK0.71719084
88CAMKK20.71210357
89PRKD30.71181895
90PDGFRB0.71090118
91CCNB10.70293472
92CDK60.70237670
93SGK10.69278779
94CHEK10.69107516
95MYLK0.68513486
96BRAF0.66428837
97RPS6KB20.64387105
98CDK180.63619848
99CDK150.62708732
100CDK70.62335002
101VRK20.62287484
102ABL20.61712727
103RAF10.61592895
104GSK3A0.61170997
105TRPM70.61057345
106* CDK20.61039258
107MKNK20.59738469
108MAP3K30.59298584
109PIM10.58712138
110NEK90.58090156
111MKNK10.57337629
112MAP3K140.57059679
113MAPK100.56860191
114DYRK1A0.56374922
115MAP2K10.55897259
116MAP3K20.55185806
117CDK80.54882992
118AKT30.54683218
119MAP2K40.54415778
120AURKB0.54224302
121PLK10.53981727
122CDK50.53772409
123NTRK10.53670608
124MAP3K70.53366024
125PAK20.53075043
126CDK11A0.51593122
127STK110.51553066
128MAP2K30.51305946
129PRKCH0.50322071
130ERBB40.50127061
131TIE10.49887164
132PAK10.49710085
133PTK2B0.49199200
134PRKCG0.48736255
135PRKDC0.48144271
136EIF2AK10.48035876
137CLK10.47993256
138CDK10.47560984
139RIPK40.47433392
140CHEK20.45939864
141CSNK1E0.45586579
142MAPK80.45566955
143ITK0.45520910
144TAOK20.45456311
145STK30.45407083
146TAF10.44735508
147* GSK3B0.43078309
148CDK140.43068849
149WEE10.42384654
150WNK10.41880907
151SGK2230.41753065
152ZAP700.39699585
153ILK0.39638025
154MAPKAPK20.39001299
155STK38L0.36207551
156GRK50.34903033

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.23565864
2Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.07023624
3Proteasome_Homo sapiens_hsa030501.88231749
4Synaptic vesicle cycle_Homo sapiens_hsa047211.78805431
5Nitrogen metabolism_Homo sapiens_hsa009101.67322972
6Long-term potentiation_Homo sapiens_hsa047201.60279539
7Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.56528351
8Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.55884902
9Mismatch repair_Homo sapiens_hsa034301.52890775
10Nicotine addiction_Homo sapiens_hsa050331.51171827
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.48220817
12Nucleotide excision repair_Homo sapiens_hsa034201.45033722
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.44895504
14N-Glycan biosynthesis_Homo sapiens_hsa005101.44827453
15Non-homologous end-joining_Homo sapiens_hsa034501.43941781
16Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.43138304
17Pentose phosphate pathway_Homo sapiens_hsa000301.40960457
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.39416656
19mTOR signaling pathway_Homo sapiens_hsa041501.39259067
20Bladder cancer_Homo sapiens_hsa052191.38762869
21Proteoglycans in cancer_Homo sapiens_hsa052051.33335335
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31744862
23Salivary secretion_Homo sapiens_hsa049701.30272270
24Biosynthesis of amino acids_Homo sapiens_hsa012301.25618092
25MicroRNAs in cancer_Homo sapiens_hsa052061.24541767
26Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23225482
27Glioma_Homo sapiens_hsa052141.21753763
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.16107907
29Hippo signaling pathway_Homo sapiens_hsa043901.14692757
30Other glycan degradation_Homo sapiens_hsa005111.14001552
31Thyroid hormone signaling pathway_Homo sapiens_hsa049191.13856430
32Pyrimidine metabolism_Homo sapiens_hsa002401.13714800
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.13214669
34Glutamatergic synapse_Homo sapiens_hsa047241.12841647
35Galactose metabolism_Homo sapiens_hsa000521.11627872
36ErbB signaling pathway_Homo sapiens_hsa040121.09691719
37Chronic myeloid leukemia_Homo sapiens_hsa052201.09661312
38ECM-receptor interaction_Homo sapiens_hsa045121.09198902
39Olfactory transduction_Homo sapiens_hsa047401.08795584
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07615715
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.06338241
42Gastric acid secretion_Homo sapiens_hsa049711.06300670
43Fructose and mannose metabolism_Homo sapiens_hsa000511.06047535
44Estrogen signaling pathway_Homo sapiens_hsa049151.04405165
45Small cell lung cancer_Homo sapiens_hsa052221.03984040
46Focal adhesion_Homo sapiens_hsa045101.02701634
47Gap junction_Homo sapiens_hsa045401.02609116
48Amphetamine addiction_Homo sapiens_hsa050311.02590519
49Long-term depression_Homo sapiens_hsa047301.02221029
50GnRH signaling pathway_Homo sapiens_hsa049121.02168210
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02136506
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02066294
53PI3K-Akt signaling pathway_Homo sapiens_hsa041511.01387734
54Glycosaminoglycan degradation_Homo sapiens_hsa005311.00984490
55Neurotrophin signaling pathway_Homo sapiens_hsa047221.00213716
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.99425897
57Circadian entrainment_Homo sapiens_hsa047130.97291521
58Adherens junction_Homo sapiens_hsa045200.96971683
59Base excision repair_Homo sapiens_hsa034100.96844576
60Type II diabetes mellitus_Homo sapiens_hsa049300.95672988
61p53 signaling pathway_Homo sapiens_hsa041150.95433520
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95172665
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94697735
64RNA transport_Homo sapiens_hsa030130.93738357
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93354033
66Regulation of actin cytoskeleton_Homo sapiens_hsa048100.92621550
67Oxytocin signaling pathway_Homo sapiens_hsa049210.91878545
68Prion diseases_Homo sapiens_hsa050200.91505950
69Oocyte meiosis_Homo sapiens_hsa041140.91500303
70Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.91387563
71One carbon pool by folate_Homo sapiens_hsa006700.91015107
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.90522516
73TGF-beta signaling pathway_Homo sapiens_hsa043500.89759207
74Dorso-ventral axis formation_Homo sapiens_hsa043200.89612159
75Prostate cancer_Homo sapiens_hsa052150.89304184
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88903530
77Colorectal cancer_Homo sapiens_hsa052100.88283970
78MAPK signaling pathway_Homo sapiens_hsa040100.88215807
79Pathways in cancer_Homo sapiens_hsa052000.87221755
80Apoptosis_Homo sapiens_hsa042100.86296251
81Spliceosome_Homo sapiens_hsa030400.86245334
82Steroid biosynthesis_Homo sapiens_hsa001000.85889593
83Non-small cell lung cancer_Homo sapiens_hsa052230.84355955
84TNF signaling pathway_Homo sapiens_hsa046680.84347230
85Endometrial cancer_Homo sapiens_hsa052130.83571721
86GABAergic synapse_Homo sapiens_hsa047270.82315799
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.81485105
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81228182
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.81003606
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80928931
91Rap1 signaling pathway_Homo sapiens_hsa040150.80397345
92Inositol phosphate metabolism_Homo sapiens_hsa005620.77963898
93HIF-1 signaling pathway_Homo sapiens_hsa040660.77633774
94Dilated cardiomyopathy_Homo sapiens_hsa054140.76784731
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76630825
96VEGF signaling pathway_Homo sapiens_hsa043700.76305790
97Dopaminergic synapse_Homo sapiens_hsa047280.75914105
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75331601
99mRNA surveillance pathway_Homo sapiens_hsa030150.75120406
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.74815758
101Pancreatic cancer_Homo sapiens_hsa052120.74674059
102Cell cycle_Homo sapiens_hsa041100.74144888
103Shigellosis_Homo sapiens_hsa051310.73468286
104T cell receptor signaling pathway_Homo sapiens_hsa046600.71364564
105Salmonella infection_Homo sapiens_hsa051320.70752206
106Protein digestion and absorption_Homo sapiens_hsa049740.69573377
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69013413
108Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68746336
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68490495
110HTLV-I infection_Homo sapiens_hsa051660.68063647
111Cholinergic synapse_Homo sapiens_hsa047250.67443082
112Amoebiasis_Homo sapiens_hsa051460.66389049
113Carbon metabolism_Homo sapiens_hsa012000.66085382
114Morphine addiction_Homo sapiens_hsa050320.65838979
115Renal cell carcinoma_Homo sapiens_hsa052110.64972949
116Choline metabolism in cancer_Homo sapiens_hsa052310.64155077
117Vibrio cholerae infection_Homo sapiens_hsa051100.64154924
118Endocytosis_Homo sapiens_hsa041440.63851335
119FoxO signaling pathway_Homo sapiens_hsa040680.62565327
120Hepatitis B_Homo sapiens_hsa051610.62460219
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62364189
122Vitamin B6 metabolism_Homo sapiens_hsa007500.61730428
123Viral carcinogenesis_Homo sapiens_hsa052030.60259051
124Mineral absorption_Homo sapiens_hsa049780.60048806
125RNA polymerase_Homo sapiens_hsa030200.59189481
126Circadian rhythm_Homo sapiens_hsa047100.58875580
127Melanoma_Homo sapiens_hsa052180.58658405
128Tight junction_Homo sapiens_hsa045300.58012875
129Thyroid hormone synthesis_Homo sapiens_hsa049180.57924337
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.56934101
131Lysosome_Homo sapiens_hsa041420.56681216
132Sphingolipid metabolism_Homo sapiens_hsa006000.56483772
133Wnt signaling pathway_Homo sapiens_hsa043100.56278377
134Fatty acid biosynthesis_Homo sapiens_hsa000610.55810266
1352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55552474
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55235269
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54694341
138Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54172158
139Insulin secretion_Homo sapiens_hsa049110.54171007
140Cocaine addiction_Homo sapiens_hsa050300.53626773
141Thyroid cancer_Homo sapiens_hsa052160.53474727
142Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53298060
143Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53137811
144Basal cell carcinoma_Homo sapiens_hsa052170.52600099
145Lysine degradation_Homo sapiens_hsa003100.48766174
146Axon guidance_Homo sapiens_hsa043600.48070346
147Fanconi anemia pathway_Homo sapiens_hsa034600.46186727
148Glutathione metabolism_Homo sapiens_hsa004800.45469624
149Acute myeloid leukemia_Homo sapiens_hsa052210.45366457
150Protein export_Homo sapiens_hsa030600.44027108
151Toxoplasmosis_Homo sapiens_hsa051450.42733167

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