SLC22A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1omega-hydroxylase P450 pathway (GO:0097267)8.87499624
2epoxygenase P450 pathway (GO:0019373)8.78680775
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.55443012
4L-phenylalanine catabolic process (GO:0006559)7.55443012
5L-phenylalanine metabolic process (GO:0006558)7.26782983
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.26782983
7aromatic amino acid family catabolic process (GO:0009074)6.88004108
8oxidative demethylation (GO:0070989)6.51649011
9indole-containing compound catabolic process (GO:0042436)6.27756933
10indolalkylamine catabolic process (GO:0046218)6.27756933
11tryptophan catabolic process (GO:0006569)6.27756933
12glyoxylate metabolic process (GO:0046487)6.08132738
13kynurenine metabolic process (GO:0070189)6.03505060
14tryptophan metabolic process (GO:0006568)5.91599391
15blood coagulation, intrinsic pathway (GO:0007597)5.87908822
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.87898927
17bile acid biosynthetic process (GO:0006699)5.82312615
18cysteine metabolic process (GO:0006534)5.71018922
19phenylpropanoid metabolic process (GO:0009698)5.58845374
20alpha-linolenic acid metabolic process (GO:0036109)5.44344506
21sulfur amino acid catabolic process (GO:0000098)5.39115652
22urea metabolic process (GO:0019627)5.39004936
23urea cycle (GO:0000050)5.39004936
24regulation of plasminogen activation (GO:0010755)5.30465102
25serine family amino acid catabolic process (GO:0009071)5.29586959
26ethanol metabolic process (GO:0006067)5.27554714
27lysine catabolic process (GO:0006554)5.25248769
28lysine metabolic process (GO:0006553)5.25248769
29high-density lipoprotein particle remodeling (GO:0034375)5.17056763
30negative regulation of fibrinolysis (GO:0051918)5.13801269
31fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.09855313
32protein carboxylation (GO:0018214)5.04313518
33peptidyl-glutamic acid carboxylation (GO:0017187)5.04313518
34aromatic amino acid family metabolic process (GO:0009072)5.01482382
35nitrogen cycle metabolic process (GO:0071941)4.97921793
36S-adenosylmethionine metabolic process (GO:0046500)4.97483203
37homocysteine metabolic process (GO:0050667)4.97223042
38bile acid metabolic process (GO:0008206)4.95977857
39protein activation cascade (GO:0072376)4.93479655
40regulation of fibrinolysis (GO:0051917)4.92795980
41complement activation, alternative pathway (GO:0006957)4.92727291
42negative regulation of blood coagulation (GO:0030195)4.92403484
43negative regulation of hemostasis (GO:1900047)4.92403484
44alkaloid metabolic process (GO:0009820)4.88716420
45regulation of protein activation cascade (GO:2000257)4.86326770
46amino-acid betaine metabolic process (GO:0006577)4.76566671
47alpha-amino acid catabolic process (GO:1901606)4.72551973
48tyrosine metabolic process (GO:0006570)4.69138582
49cellular ketone body metabolic process (GO:0046950)4.69053844
50complement activation (GO:0006956)4.62817969
51acute-phase response (GO:0006953)4.56928203
52complement activation, classical pathway (GO:0006958)4.56572628
53regulation of complement activation (GO:0030449)4.54538631
54regulation of triglyceride catabolic process (GO:0010896)4.53960116
55negative regulation of cholesterol transport (GO:0032375)4.50745519
56negative regulation of sterol transport (GO:0032372)4.50745519
57regulation of cholesterol esterification (GO:0010872)4.48893456
58reverse cholesterol transport (GO:0043691)4.48524494
59negative regulation of coagulation (GO:0050819)4.47664531
60drug catabolic process (GO:0042737)4.46511551
61indolalkylamine metabolic process (GO:0006586)4.45119853
62regulation of humoral immune response (GO:0002920)4.43374819
63negative regulation of wound healing (GO:0061045)4.40924044
64cellular amino acid catabolic process (GO:0009063)4.40585525
65serine family amino acid metabolic process (GO:0009069)4.40362833
66protein-lipid complex remodeling (GO:0034368)4.39719443
67macromolecular complex remodeling (GO:0034367)4.39719443
68plasma lipoprotein particle remodeling (GO:0034369)4.39719443
69glutamate metabolic process (GO:0006536)4.37987405
70acylglycerol homeostasis (GO:0055090)4.37117450
71triglyceride homeostasis (GO:0070328)4.37117450
72glycine metabolic process (GO:0006544)4.36245006
73cellular modified amino acid catabolic process (GO:0042219)4.34204741
74cellular glucuronidation (GO:0052695)4.33245325
75amine catabolic process (GO:0009310)4.32517561
76cellular biogenic amine catabolic process (GO:0042402)4.32517561
77coenzyme catabolic process (GO:0009109)4.31474654
78fat-soluble vitamin biosynthetic process (GO:0042362)4.30837524
79opsonization (GO:0008228)4.27213575
80urate metabolic process (GO:0046415)4.26548826
81positive regulation of blood coagulation (GO:0030194)4.26256247
82positive regulation of hemostasis (GO:1900048)4.26256247
83bile acid and bile salt transport (GO:0015721)4.24407604
84benzene-containing compound metabolic process (GO:0042537)4.23903035
85negative regulation of protein activation cascade (GO:2000258)4.23463318
86killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.20090172
87disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.20090172
88phospholipid efflux (GO:0033700)4.19336562
89ethanol oxidation (GO:0006069)4.16414275
90serine family amino acid biosynthetic process (GO:0009070)4.13145048
91short-chain fatty acid metabolic process (GO:0046459)4.09049709
92ketone body metabolic process (GO:1902224)4.06012107
93hormone catabolic process (GO:0042447)4.04668282
94plasma lipoprotein particle clearance (GO:0034381)4.02910171
95aldehyde catabolic process (GO:0046185)4.02842878
96dicarboxylic acid biosynthetic process (GO:0043650)4.02361995
97imidazole-containing compound metabolic process (GO:0052803)4.01599148
98exogenous drug catabolic process (GO:0042738)3.99599282
99cytolysis (GO:0019835)3.99443138
100positive regulation of coagulation (GO:0050820)3.94689922
101uronic acid metabolic process (GO:0006063)3.92342126
102glucuronate metabolic process (GO:0019585)3.92342126
103arginine metabolic process (GO:0006525)3.89532480
104* drug transmembrane transport (GO:0006855)3.89064361
105acetyl-CoA metabolic process (GO:0006084)3.88933181
106negative regulation of lipase activity (GO:0060192)3.88212282
107organic acid catabolic process (GO:0016054)3.87611979
108carboxylic acid catabolic process (GO:0046395)3.87611979
109intestinal cholesterol absorption (GO:0030299)3.86364580
110cholesterol efflux (GO:0033344)3.86273314
111response to mercury ion (GO:0046689)3.86251499
112aspartate family amino acid catabolic process (GO:0009068)3.83270694
113heme transport (GO:0015886)3.80046066
114positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.77892576
1152-oxoglutarate metabolic process (GO:0006103)3.72414026
116fibrinolysis (GO:0042730)3.71260437
117regulation of cholesterol homeostasis (GO:2000188)3.70488665
118regulation of bile acid biosynthetic process (GO:0070857)3.70083695
119flavonoid metabolic process (GO:0009812)3.67948603
120plasma lipoprotein particle assembly (GO:0034377)3.65825060
121polyketide metabolic process (GO:0030638)3.64508834
122doxorubicin metabolic process (GO:0044598)3.64508834
123daunorubicin metabolic process (GO:0044597)3.64508834
124low-density lipoprotein particle remodeling (GO:0034374)3.64043432
125cofactor catabolic process (GO:0051187)3.63013647
126xenobiotic metabolic process (GO:0006805)3.62926845
127steroid catabolic process (GO:0006706)3.62415414
128fatty acid oxidation (GO:0019395)3.61234763
129fatty acid beta-oxidation (GO:0006635)3.59991369
130monocarboxylic acid catabolic process (GO:0072329)3.59178260
131cholesterol homeostasis (GO:0042632)3.58249864
132drug metabolic process (GO:0017144)3.58173905
133positive regulation of lipoprotein lipase activity (GO:0051006)3.56915015
134positive regulation of triglyceride lipase activity (GO:0061365)3.56915015
135carnitine metabolic process (GO:0009437)3.55648940
136phospholipid homeostasis (GO:0055091)3.55068461
137sterol homeostasis (GO:0055092)3.54501985
138lipid oxidation (GO:0034440)3.54248329
139sodium-independent organic anion transport (GO:0043252)3.48682662
140negative regulation of complement activation (GO:0045916)3.48567064
141acute inflammatory response (GO:0002526)3.43509575

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.31261539
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.13202520
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.72951734
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.40594425
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.10777758
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.94599437
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.85462234
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.97251896
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.86738138
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.14750226
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11505220
12* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.05776036
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7514931
14CLOCK_20551151_ChIP-Seq_293T_Human1.63946336
15* FOXA2_19822575_ChIP-Seq_HepG2_Human1.61016249
16* HNF4A_19822575_ChIP-Seq_HepG2_Human1.45927627
17HTT_18923047_ChIP-ChIP_STHdh_Human1.37640944
18GATA1_22025678_ChIP-Seq_K562_Human1.29097448
19* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.26329600
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16025761
21RXRA_24833708_ChIP-Seq_LIVER_Mouse1.15875822
22ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12111390
23SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08480544
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08108774
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06172907
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05150860
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.01275438
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.00072015
29ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98289971
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96948676
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96137008
32GATA4_25053715_ChIP-Seq_YYC3_Human0.94168137
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88194481
34ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86617395
35ESR2_21235772_ChIP-Seq_MCF-7_Human0.86136720
36HNFA_21074721_ChIP-Seq_CACO-2_Human0.81653035
37ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81591021
38IRF8_22096565_ChIP-ChIP_GC-B_Human0.81044825
39AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80902505
40CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.79735253
41BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77309601
42SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76643363
43KAP1_22055183_ChIP-Seq_ESCs_Mouse0.76550991
44ESR1_21235772_ChIP-Seq_MCF-7_Human0.75604144
45IRF1_19129219_ChIP-ChIP_H3396_Human0.74864157
46PHF8_20622853_ChIP-Seq_HELA_Human0.74585721
47ZNF263_19887448_ChIP-Seq_K562_Human0.74557963
48* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.74081363
49Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.72677375
50NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.72080388
51CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71890154
52SOX2_21211035_ChIP-Seq_LN229_Human0.71338134
53RARA_24833708_ChIP-Seq_LIVER_Mouse0.70730773
54SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.70540812
55TP53_18474530_ChIP-ChIP_U2OS_Human0.70527126
56RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.70122717
57SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69391402
58GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.67663659
59NFE2_27457419_Chip-Seq_LIVER_Mouse0.67433352
60CDX2_20551321_ChIP-Seq_CACO-2_Human0.67263383
61NFYA_21822215_ChIP-Seq_K562_Human0.67001984
62NRF2_20460467_ChIP-Seq_MEFs_Mouse0.66824721
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.66824721
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.65737221
65BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.64910193
66FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.64720446
67RAD21_21589869_ChIP-Seq_MESCs_Mouse0.64708131
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.63554673
69PIAS1_25552417_ChIP-Seq_VCAP_Human0.63128388
70LXR_22292898_ChIP-Seq_THP-1_Human0.62853868
71STAT3_1855785_ChIP-Seq_MESCs_Mouse0.61266058
72EGR1_19032775_ChIP-ChIP_M12_Human0.61195816
73GATA6_21074721_ChIP-Seq_CACO-2_Human0.60833975
74RARB_24833708_ChIP-Seq_LIVER_Mouse0.60113097
75CEBPB_22108803_ChIP-Seq_LS180_Human0.59181329
76FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.59101936
77RAC3_21632823_ChIP-Seq_H3396_Human0.58977410
78EZH2_27294783_Chip-Seq_NPCs_Mouse0.58680253
79ETV2_25802403_ChIP-Seq_MESCs_Mouse0.58271424
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.58011225
81SPI1_20517297_ChIP-Seq_HL60_Human0.57155045
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.55913220
83MYC_19915707_ChIP-ChIP_AK7_Human0.54940544
84AR_20517297_ChIP-Seq_VCAP_Human0.54897589
85FOXA1_25552417_ChIP-Seq_VCAP_Human0.54456759
86CBX2_22325352_ChIP-Seq_293T-Rex_Human0.53400939
87FOXO3_23340844_ChIP-Seq_DLD1_Human0.53180546
88ESET_19884257_ChIP-Seq_ESCs_Mouse0.52874834
89GATA6_25053715_ChIP-Seq_YYC3_Human0.52779528
90PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51960273
91SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.50521788
92ER_23166858_ChIP-Seq_MCF-7_Human0.49965779
93CBP_21632823_ChIP-Seq_H3396_Human0.49380069
94STAT1_17558387_ChIP-Seq_HELA_Human0.49135084
95FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.48928385
96NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.48912363
97ERG_20517297_ChIP-Seq_VCAP_Human0.48735102
98KLF5_20875108_ChIP-Seq_MESCs_Mouse0.48391460
99CRX_20693478_ChIP-Seq_RETINA_Mouse0.47459932
100FOXH1_21741376_ChIP-Seq_EPCs_Human0.47272107
101MYC_19829295_ChIP-Seq_ESCs_Human0.47036574
102EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.46990281
103PPAR_26484153_Chip-Seq_NCI-H1993_Human0.46862668
104ERG_21242973_ChIP-ChIP_JURKAT_Human0.46821414
105FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.46353699
106ETV1_20927104_ChIP-Seq_GIST48_Human0.46135773
107PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.45837161
108FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.45768551
109SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.45584210
110PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.45537266
111P53_21459846_ChIP-Seq_SAOS-2_Human0.44750446
112* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44257897
113TAF2_19829295_ChIP-Seq_ESCs_Human0.43953208
114ESR1_20079471_ChIP-ChIP_T-47D_Human0.43162105
115SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42632789
116GATA2_19941826_ChIP-Seq_K562_Human0.42420513
117GATA1_19941827_ChIP-Seq_MEL_Mouse0.42031149
118SOX2_20726797_ChIP-Seq_SW620_Human0.41809971
119E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.41091173
120GATA1_19941826_ChIP-Seq_K562_Human0.40433112
121STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.39859237
122ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.39248942
123SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.38551086
124BCAT_22108803_ChIP-Seq_LS180_Human0.38492276
125NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.38059041
126GATA3_24758297_ChIP-Seq_MCF-7_Human0.37809711
127EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.37546229
128GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.37512024
129CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.37209758
130CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.37007150
131LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36867445
132RACK7_27058665_Chip-Seq_MCF-7_Human0.36827480
133P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.36414803

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.99644682
2* MP0002139_abnormal_hepatobiliary_system7.60669831
3MP0005085_abnormal_gallbladder_physiolo6.29044493
4MP0005365_abnormal_bile_salt6.07517382
5* MP0008875_abnormal_xenobiotic_pharmacok4.90946638
6MP0003806_abnormal_nucleotide_metabolis4.12034606
7MP0003252_abnormal_bile_duct3.97016029
8MP0010329_abnormal_lipoprotein_level3.43539056
9MP0005332_abnormal_amino_acid3.20397979
10MP0003195_calcinosis3.10518457
11MP0009840_abnormal_foam_cell3.05942477
12MP0005083_abnormal_biliary_tract2.84835749
13MP0004019_abnormal_vitamin_homeostasis2.61425717
14MP0001666_abnormal_nutrient_absorption2.61284052
15MP0002138_abnormal_hepatobiliary_system2.26215058
16MP0003191_abnormal_cellular_cholesterol2.24866801
17MP0002118_abnormal_lipid_homeostasis2.07480612
18* MP0000609_abnormal_liver_physiology2.06677738
19MP0005319_abnormal_enzyme/_coenzyme1.89900004
20MP0003868_abnormal_feces_composition1.81258107
21MP0001764_abnormal_homeostasis1.69454721
22MP0009643_abnormal_urine_homeostasis1.66896195
23MP0005584_abnormal_enzyme/coenzyme_acti1.66738536
24MP0005451_abnormal_body_composition1.58137938
25MP0003186_abnormal_redox_activity1.41810559
26MP0009697_abnormal_copulation1.33478103
27MP0005636_abnormal_mineral_homeostasis1.28554428
28MP0003011_delayed_dark_adaptation1.21448066
29MP0005647_abnormal_sex_gland1.16015933
30MP0000598_abnormal_liver_morphology1.15322800
31MP0003656_abnormal_erythrocyte_physiolo1.14234598
32MP0009764_decreased_sensitivity_to1.12924267
33MP0002132_abnormal_respiratory_system1.11335599
34MP0003705_abnormal_hypodermis_morpholog1.11114671
35MP0000604_amyloidosis1.01228512
36MP0004043_abnormal_pH_regulation0.99031775
37MP0001756_abnormal_urination0.98745133
38MP0009763_increased_sensitivity_to0.94411558
39MP0006036_abnormal_mitochondrial_physio0.93039347
40MP0002876_abnormal_thyroid_physiology0.92663860
41MP0009642_abnormal_blood_homeostasis0.90873822
42MP0008469_abnormal_protein_level0.89549267
43MP0001915_intracranial_hemorrhage0.88405179
44MP0005084_abnormal_gallbladder_morpholo0.85988745
45MP0002254_reproductive_system_inflammat0.85654862
46MP0005408_hypopigmentation0.84790159
47MP0005670_abnormal_white_adipose0.84524802
48MP0002136_abnormal_kidney_physiology0.80786942
49MP0009765_abnormal_xenobiotic_induced0.79845924
50MP0002078_abnormal_glucose_homeostasis0.77960511
51MP0005376_homeostasis/metabolism_phenot0.77005994
52MP0010368_abnormal_lymphatic_system0.76470946
53MP0005220_abnormal_exocrine_pancreas0.75957088
54MP0005535_abnormal_body_temperature0.75242670
55MP0005187_abnormal_penis_morphology0.74629656
56MP0003879_abnormal_hair_cell0.72987251
57MP0009785_altered_susceptibility_to0.71798788
58MP0002282_abnormal_trachea_morphology0.71335559
59MP0001661_extended_life_span0.70161699
60MP0002971_abnormal_brown_adipose0.68893467
61MP0001765_abnormal_ion_homeostasis0.66713896
62MP0005334_abnormal_fat_pad0.65501380
63MP0004130_abnormal_muscle_cell0.63164538
64MP0003329_amyloid_beta_deposits0.62582362
65MP0005023_abnormal_wound_healing0.61722196
66MP0005266_abnormal_metabolism0.61465403
67MP0003690_abnormal_glial_cell0.61244317
68MP0009053_abnormal_anal_canal0.60649068
69MP0006035_abnormal_mitochondrial_morpho0.60164266
70MP0002928_abnormal_bile_duct0.56066469
71MP0003638_abnormal_response/metabolism_0.55530302
72MP0005395_other_phenotype0.52687003
73MP0002249_abnormal_larynx_morphology0.50286731
74MP0005058_abnormal_lysosome_morphology0.50057806
75MP0000639_abnormal_adrenal_gland0.49533162
76MP0005448_abnormal_energy_balance0.49076395
77MP0005164_abnormal_response_to0.47131332
78MP0005666_abnormal_adipose_tissue0.46845441
79MP0000230_abnormal_systemic_arterial0.46247158
80MP0004883_abnormal_blood_vessel0.45542853
81MP0002332_abnormal_exercise_endurance0.45457246
82MP0008874_decreased_physiological_sensi0.44859502
83MP0003953_abnormal_hormone_level0.43816128
84MP0004782_abnormal_surfactant_physiolog0.43434713
85MP0002822_catalepsy0.43185289
86MP0008873_increased_physiological_sensi0.42656790
87MP0002168_other_aberrant_phenotype0.42634643
88MP0005464_abnormal_platelet_physiology0.42482697
89MP0003718_maternal_effect0.42213559
90MP0005166_decreased_susceptibility_to0.41419594
91MP0002796_impaired_skin_barrier0.41103461
92MP0003075_altered_response_to0.40443308
93MP0008872_abnormal_physiological_respon0.40256181
94MP0003724_increased_susceptibility_to0.40033203
95MP0002837_dystrophic_cardiac_calcinosis0.38323467
96MP0003300_gastrointestinal_ulcer0.37609544
97MP0000538_abnormal_urinary_bladder0.37146647
98MP0001851_eye_inflammation0.37048065
99MP0009672_abnormal_birth_weight0.36082640
100MP0002135_abnormal_kidney_morphology0.34756892
101MP0010234_abnormal_vibrissa_follicle0.34172407
102MP0004264_abnormal_extraembryonic_tissu0.33798827
103MP0003436_decreased_susceptibility_to0.32988455
104MP0005248_abnormal_Harderian_gland0.32851468
105MP0009115_abnormal_fat_cell0.30814751
106MP0002419_abnormal_innate_immunity0.30634225
107MP0006082_CNS_inflammation0.30394320
108MP0001845_abnormal_inflammatory_respons0.29749326
109MP0009384_cardiac_valve_regurgitation0.29654117
110MP0003959_abnormal_lean_body0.28405455
111MP0000467_abnormal_esophagus_morphology0.27469739
112MP0000249_abnormal_blood_vessel0.27332846
113MP0002970_abnormal_white_adipose0.26924581
114MP0000579_abnormal_nail_morphology0.26811435
115MP0001545_abnormal_hematopoietic_system0.26321242
116MP0005397_hematopoietic_system_phenotyp0.26321242
117MP0004381_abnormal_hair_follicle0.26159768
118MP0003303_peritoneal_inflammation0.25554132
119MP0005025_abnormal_response_to0.24309178
120MP0005197_abnormal_uvea_morphology0.22739549
121MP0004142_abnormal_muscle_tone0.19135272
122MP0000920_abnormal_myelination0.19003098

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.14676842
2Intrahepatic cholestasis (HP:0001406)6.88109607
3Deep venous thrombosis (HP:0002625)6.74605171
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.27763739
5Xanthomatosis (HP:0000991)5.96231733
6Prolonged partial thromboplastin time (HP:0003645)5.87778567
7Hypobetalipoproteinemia (HP:0003563)5.84705400
8Hyperlipoproteinemia (HP:0010980)5.11293204
9Complement deficiency (HP:0004431)4.79498027
10Hyperammonemia (HP:0001987)4.66451696
11Abnormality of glutamine family amino acid metabolism (HP:0010902)4.65855737
12Hyperglycinemia (HP:0002154)4.57321207
13Hyperglycinuria (HP:0003108)4.53792627
14Ketosis (HP:0001946)4.51397481
15Joint hemorrhage (HP:0005261)4.39456918
16Abnormality of glycine metabolism (HP:0010895)4.34918007
17Abnormality of serine family amino acid metabolism (HP:0010894)4.34918007
18Hypolipoproteinemia (HP:0010981)4.33706018
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.28700818
20Abnormality of aspartate family amino acid metabolism (HP:0010899)4.26401041
21Epidermoid cyst (HP:0200040)4.12418493
22Abnormality of the common coagulation pathway (HP:0010990)4.02272819
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.95849168
24Abnormality of methionine metabolism (HP:0010901)3.94808471
25Fat malabsorption (HP:0002630)3.93284168
26Hypoalphalipoproteinemia (HP:0003233)3.77093828
27Hypoglycemic coma (HP:0001325)3.76846923
28Nephritis (HP:0000123)3.74525765
29Abnormality of fatty-acid metabolism (HP:0004359)3.64819909
30Abnormality of pyrimidine metabolism (HP:0004353)3.63471715
31Conjugated hyperbilirubinemia (HP:0002908)3.51914976
32Abnormality of the intrinsic pathway (HP:0010989)3.47062787
33Gout (HP:0001997)3.46556533
34Abnormality of complement system (HP:0005339)3.45916965
35Ketoacidosis (HP:0001993)3.45469346
36Abnormality of nucleobase metabolism (HP:0010932)3.39714475
37Delayed CNS myelination (HP:0002188)3.32639037
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.30688592
39Abnormality of purine metabolism (HP:0004352)3.27835855
40Hypercholesterolemia (HP:0003124)3.26919449
41Hyperbilirubinemia (HP:0002904)3.19952839
42Abnormality of serum amino acid levels (HP:0003112)3.10522531
43Metabolic acidosis (HP:0001942)2.97612923
44Steatorrhea (HP:0002570)2.96343767
45Hepatocellular carcinoma (HP:0001402)2.95028735
46Vascular calcification (HP:0004934)2.83400052
47Dicarboxylic aciduria (HP:0003215)2.82483626
48Abnormality of dicarboxylic acid metabolism (HP:0010995)2.82483626
49Lethargy (HP:0001254)2.75630335
50Osteomalacia (HP:0002749)2.70121782
51Myocardial infarction (HP:0001658)2.67531147
52Generalized aminoaciduria (HP:0002909)2.65440806
53Spontaneous abortion (HP:0005268)2.62726504
54Hypochromic microcytic anemia (HP:0004840)2.57418761
55Proximal tubulopathy (HP:0000114)2.55964683
56Purpura (HP:0000979)2.54792688
57Malnutrition (HP:0004395)2.54003749
58Alkalosis (HP:0001948)2.53445214
59Neonatal hypoglycemia (HP:0001998)2.53381065
60Fair hair (HP:0002286)2.52810743
61Systemic lupus erythematosus (HP:0002725)2.52747107
62Skin nodule (HP:0200036)2.51956472
63Cardiovascular calcification (HP:0011915)2.51161747
64Spastic diplegia (HP:0001264)2.50843931
65Irritability (HP:0000737)2.45584189
66Pulmonary embolism (HP:0002204)2.45164155
67Increased purine levels (HP:0004368)2.43489433
68Hyperuricemia (HP:0002149)2.43489433
69Neonatal onset (HP:0003623)2.43279717
70Cerebral edema (HP:0002181)2.42353050
71Hydroxyprolinuria (HP:0003080)2.32136348
72Abnormality of proline metabolism (HP:0010907)2.32136348
73Sensorimotor neuropathy (HP:0007141)2.31916583
74Vomiting (HP:0002013)2.31418258
75Reduced antithrombin III activity (HP:0001976)2.31286074
76Hypoglycemic seizures (HP:0002173)2.31257293
77Enlarged kidneys (HP:0000105)2.30044957
78Rickets (HP:0002748)2.25931272
79Mitral stenosis (HP:0001718)2.25909551
80Abnormal gallbladder morphology (HP:0012437)2.25173016
81Late onset (HP:0003584)2.22295145
82Acanthocytosis (HP:0001927)2.21291721
83Cholelithiasis (HP:0001081)2.20952642
84Glomerulonephritis (HP:0000099)2.19544718
85Pancreatitis (HP:0001733)2.18938508
86Abnormality of urine glucose concentration (HP:0011016)2.18934254
87Glycosuria (HP:0003076)2.18934254
88Cholecystitis (HP:0001082)2.18058605
89Abnormal gallbladder physiology (HP:0012438)2.18058605
90Hyperphosphaturia (HP:0003109)2.13229749
91Esophageal varix (HP:0002040)2.08968699
92Elevated alkaline phosphatase (HP:0003155)2.06625082
93Abnormal enzyme/coenzyme activity (HP:0012379)2.06338060
94Brushfield spots (HP:0001088)2.06019555
95Abnormality of vitamin metabolism (HP:0100508)2.05947878
96Recurrent gram-negative bacterial infections (HP:0005420)2.01753765
97Opisthotonus (HP:0002179)2.01074947
98Amyloidosis (HP:0011034)1.99428429
99Hypophosphatemic rickets (HP:0004912)1.98894722
100Arthropathy (HP:0003040)1.98848189
101Menorrhagia (HP:0000132)1.98062169
102Increased mean platelet volume (HP:0011877)1.93739348
103Thrombophlebitis (HP:0004418)1.93494100
104Bifid scrotum (HP:0000048)1.92714468
105Abnormal cartilage morphology (HP:0002763)1.91821658
106Gangrene (HP:0100758)1.90975142
107Abnormality of the Achilles tendon (HP:0005109)1.90787418
108Increased serum ferritin (HP:0003281)1.90512075
109Abnormality of iron homeostasis (HP:0011031)1.90338770
110Abnormality of the gallbladder (HP:0005264)1.89288118
111Joint swelling (HP:0001386)1.88314452
112Hemorrhage of the eye (HP:0011885)1.86226329
113Hyperinsulinemic hypoglycemia (HP:0000825)1.85834707
114Gingival bleeding (HP:0000225)1.83878295
115Renal cortical cysts (HP:0000803)1.82978327
116Abnormality of alkaline phosphatase activity (HP:0004379)1.82596768
117Nephrolithiasis (HP:0000787)1.82155234
118Status epilepticus (HP:0002133)1.81376439
119Abnormal platelet volume (HP:0011876)1.79536208
120Generalized hypopigmentation of hair (HP:0011358)1.76929911
121Poikilocytosis (HP:0004447)1.76414619
122Abnormality of transition element cation homeostasis (HP:0011030)1.74473962
123Abnormal urine phosphate concentration (HP:0012599)1.70606496
124Epistaxis (HP:0000421)1.69886478
125Abnormal platelet function (HP:0011869)1.66225583
126Impaired platelet aggregation (HP:0003540)1.66225583
127Abnormal biliary tract physiology (HP:0012439)1.65448629
128Bile duct proliferation (HP:0001408)1.65448629
129Hypochromic anemia (HP:0001931)1.62381185
130Atrioventricular block (HP:0001678)1.62330220
131Reticulocytosis (HP:0001923)1.53268299

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.38569873
2ERN14.37333367
3FGFR44.26741500
4SIK14.11461436
5TAOK32.81891585
6INSRR2.69522689
7PRPF4B2.57181679
8ERBB42.51497481
9MST1R2.25265315
10NTRK32.25156744
11MAP2K42.07150174
12WNK42.02845078
13PKN22.02540912
14PIK3CA1.96327167
15WNK31.94861463
16LATS11.75219915
17TRIB31.72729474
18MAPK111.72402874
19FRK1.69181164
20OXSR11.67607651
21FLT31.61511172
22PIK3CG1.61036114
23STK38L1.54808359
24TYK21.48960190
25PTK61.46696043
26ABL21.43490073
27TNK21.37503317
28MAP3K121.31774754
29DAPK21.26842479
30PINK11.26569489
31MAP3K71.25695156
32MAP3K11.22764536
33NEK91.20769263
34NLK1.17218630
35GRK61.16477203
36FGFR21.13921184
37JAK21.11674451
38KDR1.08590223
39PRKAA21.08462569
40MAP2K31.02627043
41MAP3K30.98547812
42KSR20.93436055
43FER0.92819450
44MAP3K140.92695430
45MYLK0.91940379
46EPHB10.91734259
47TBK10.91354052
48BLK0.90606068
49PRKCZ0.89605535
50ZAP700.87793444
51PRKG10.86858981
52MET0.86388257
53ERBB20.86087846
54JAK10.85089480
55MAPK40.83264718
56SGK30.81056034
57PDK30.79853196
58PDK40.79853196
59TIE10.79794840
60MAP3K100.78629081
61GSK3A0.78023546
62MAPK150.77061770
63SGK2230.76494992
64SGK4940.76494992
65PRKACA0.74617459
66DYRK1B0.73575775
67PRKAA10.72994591
68MAP3K110.72328443
69MAPK120.70915960
70PRKACG0.69519208
71MAP2K60.65410716
72PTK20.65155823
73STK390.65042618
74SGK20.64965855
75CAMKK20.64189151
76IRAK30.63825923
77CDK60.63641010
78IRAK10.62934672
79CSK0.61062988
80TGFBR20.60916129
81RIPK10.60878656
82CAMK2G0.60432279
83PDPK10.59024841
84ARAF0.58197344
85CSNK1D0.51869156
86PRKCB0.51060491
87MUSK0.50015815
88CAMK1D0.48431740
89PRKCQ0.47864993
90EPHA30.47379596
91PDK20.46622826
92NEK10.46218207
93RPS6KA30.45746027
94SGK10.45288292
95AKT30.43683674
96CSF1R0.42878724
97MAPK70.42815492
98TAOK10.42708014
99IKBKE0.41875906
100FGFR30.41839870
101STK380.38203072
102CSNK1G10.38141423
103CHUK0.38122834
104GRK10.38080417
105PDK10.37360440
106IGF1R0.37025740
107IKBKB0.36760535
108SRC0.36626140
109JAK30.36495732
110EPHA40.36064444
111PIM20.35767945
112MAP2K10.35655128
113MAP3K50.34430822
114PRKACB0.33117317
115STK160.32582927
116MTOR0.32207111
117ICK0.32162688
118TAOK20.31932593
119RET0.31505409
120PRKCG0.31108964
121IRAK20.29665102
122MAP2K20.29271983
123MAP4K10.29059273
124MAP3K130.28261469
125CAMKK10.28071903
126EGFR0.27199197
127MAP3K20.27154051
128MAP3K60.26635721
129PRKCA0.26452040
130CAMK40.26020296
131CDK40.24615711
132PAK30.23662644

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.26276945
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.49778929
3Nitrogen metabolism_Homo sapiens_hsa009103.33051083
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.24942712
5Arginine biosynthesis_Homo sapiens_hsa002202.92392293
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.74491408
7Tryptophan metabolism_Homo sapiens_hsa003802.72990042
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.64671309
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.55404992
10Fatty acid degradation_Homo sapiens_hsa000712.55092733
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.50802693
12Complement and coagulation cascades_Homo sapiens_hsa046102.45463167
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.42711749
14Butanoate metabolism_Homo sapiens_hsa006502.37709028
15Peroxisome_Homo sapiens_hsa041462.18183233
16Propanoate metabolism_Homo sapiens_hsa006402.11228690
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09802459
18Chemical carcinogenesis_Homo sapiens_hsa052041.89328634
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87979751
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.87766776
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.87306307
22Histidine metabolism_Homo sapiens_hsa003401.85339316
23PPAR signaling pathway_Homo sapiens_hsa033201.85058162
24Fatty acid metabolism_Homo sapiens_hsa012121.84242058
25beta-Alanine metabolism_Homo sapiens_hsa004101.78367656
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.70941105
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.70420623
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.68523068
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66151888
30Retinol metabolism_Homo sapiens_hsa008301.64985738
31Caffeine metabolism_Homo sapiens_hsa002321.64459206
32Selenocompound metabolism_Homo sapiens_hsa004501.55398334
33Pyruvate metabolism_Homo sapiens_hsa006201.52172025
34Staphylococcus aureus infection_Homo sapiens_hsa051501.51567511
35Phenylalanine metabolism_Homo sapiens_hsa003601.50165934
36Sulfur metabolism_Homo sapiens_hsa009201.50011896
37* Bile secretion_Homo sapiens_hsa049761.47533246
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34159294
39Tyrosine metabolism_Homo sapiens_hsa003501.33650925
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.31943611
41Starch and sucrose metabolism_Homo sapiens_hsa005001.31605215
42Fatty acid elongation_Homo sapiens_hsa000621.29910613
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.27158685
44Folate biosynthesis_Homo sapiens_hsa007901.22791075
45Carbon metabolism_Homo sapiens_hsa012001.21516436
46Biosynthesis of amino acids_Homo sapiens_hsa012301.19829287
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14965282
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13619457
49ABC transporters_Homo sapiens_hsa020101.12785676
50Steroid biosynthesis_Homo sapiens_hsa001001.09939140
51Fat digestion and absorption_Homo sapiens_hsa049751.07284743
52Arginine and proline metabolism_Homo sapiens_hsa003301.04973015
53Vitamin digestion and absorption_Homo sapiens_hsa049771.01277690
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.97824188
55Sulfur relay system_Homo sapiens_hsa041220.92859656
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91135959
57Lysine degradation_Homo sapiens_hsa003100.88400267
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81880268
59Vitamin B6 metabolism_Homo sapiens_hsa007500.81298988
60Glutathione metabolism_Homo sapiens_hsa004800.78929495
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77133434
62Glycerolipid metabolism_Homo sapiens_hsa005610.72573397
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70829240
64One carbon pool by folate_Homo sapiens_hsa006700.67189941
65Pentose phosphate pathway_Homo sapiens_hsa000300.59680058
66Metabolic pathways_Homo sapiens_hsa011000.48539574
67Fatty acid biosynthesis_Homo sapiens_hsa000610.42796135
68Fructose and mannose metabolism_Homo sapiens_hsa000510.35096780
69Pertussis_Homo sapiens_hsa051330.33883628
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30794684
71Prion diseases_Homo sapiens_hsa050200.25657391
72Galactose metabolism_Homo sapiens_hsa000520.25498984
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24216989
74Insulin resistance_Homo sapiens_hsa049310.21821043
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20621491
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.20577292
77Linoleic acid metabolism_Homo sapiens_hsa005910.17621154
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.11632537
79Systemic lupus erythematosus_Homo sapiens_hsa053220.07531284
80Glucagon signaling pathway_Homo sapiens_hsa049220.07107580
81AMPK signaling pathway_Homo sapiens_hsa041520.01946859
82FoxO signaling pathway_Homo sapiens_hsa04068-0.2828736
83Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.2558467
84Circadian rhythm_Homo sapiens_hsa04710-0.2422424
85Bladder cancer_Homo sapiens_hsa05219-0.2241247
86African trypanosomiasis_Homo sapiens_hsa05143-0.2108133
87Other glycan degradation_Homo sapiens_hsa00511-0.2050938
88Lysosome_Homo sapiens_hsa04142-0.2043758
89Type II diabetes mellitus_Homo sapiens_hsa04930-0.1969554
90Sphingolipid metabolism_Homo sapiens_hsa00600-0.1886683
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1818838
92Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1809270
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1693994
94Hepatitis C_Homo sapiens_hsa05160-0.1584509
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1358059
96Protein digestion and absorption_Homo sapiens_hsa04974-0.1351923
97Regulation of autophagy_Homo sapiens_hsa04140-0.1350508
98Mineral absorption_Homo sapiens_hsa04978-0.1330881
99Insulin signaling pathway_Homo sapiens_hsa04910-0.1256790
100Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1222498
101Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1071390
102Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1054990
103Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0983047
104Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0843922
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0778254
106Renin-angiotensin system_Homo sapiens_hsa04614-0.0433726
107Serotonergic synapse_Homo sapiens_hsa04726-0.0149418
108Amoebiasis_Homo sapiens_hsa05146-0.0137073
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0097460

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