ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	epoxygenase P450 pathway (GO:0019373)	9.28417335
2	omega-hydroxylase P450 pathway (GO:0097267)	9.11750599
3	exogenous drug catabolic process (GO:0042738)	9.04979318
4	drug catabolic process (GO:0042737)	8.87638923
5	glyoxylate metabolic process (GO:0046487)	8.66631729
6	complement activation, alternative pathway (GO:0006957)	8.56406312
7	regulation of fibrinolysis (GO:0051917)	8.30506995
8	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	8.03744770
9	L-phenylalanine catabolic process (GO:0006559)	8.03744770
10	regulation of protein activation cascade (GO:2000257)	7.84616525
11	ethanol oxidation (GO:0006069)	7.69526781
12	negative regulation of fibrinolysis (GO:0051918)	7.67675667
13	regulation of complement activation (GO:0030449)	7.46600601
14	L-phenylalanine metabolic process (GO:0006558)	7.29414355
15	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	7.29414355
16	urea metabolic process (GO:0019627)	6.64790899
17	fibrinolysis (GO:0042730)	6.59154822
18	peptidyl-glutamic acid carboxylation (GO:0017187)	6.41566700
19	protein carboxylation (GO:0018214)	6.41566700
20	drug metabolic process (GO:0017144)	6.38638273
21	ethanol metabolic process (GO:0006067)	6.15115454
22	imidazole-containing compound metabolic process (GO:0052803)	6.14563011
23	oxidative demethylation (GO:0070989)	6.10734487
24	blood coagulation, intrinsic pathway (GO:0007597)	6.09526187
25	nitrogen cycle metabolic process (GO:0071941)	6.05225908
26	cellular glucuronidation (GO:0052695)	5.91215339
27	aromatic amino acid family catabolic process (GO:0009074)	5.89811950
28	serine family amino acid catabolic process (GO:0009071)	5.86755497
29	negative regulation of sterol transport (GO:0032372)	5.69201637
30	negative regulation of cholesterol transport (GO:0032375)	5.69201637
31	urea cycle (GO:0000050)	5.68459346
32	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	5.62122185
33	uronic acid metabolic process (GO:0006063)	5.59596650
34	glucuronate metabolic process (GO:0019585)	5.59596650
35	bile acid biosynthetic process (GO:0006699)	5.56263423
36	regulation of plasminogen activation (GO:0010755)	5.49626352
37	phenylpropanoid metabolic process (GO:0009698)	5.48844723
38	protein activation cascade (GO:0072376)	5.36897366
39	regulation of triglyceride catabolic process (GO:0010896)	5.33494152
40	glycine metabolic process (GO:0006544)	5.21158204
41	complement activation (GO:0006956)	5.15377324
42	complement activation, classical pathway (GO:0006958)	5.02955526
43	bile acid metabolic process (GO:0008206)	5.02407428
44	opsonization (GO:0008228)	4.85871642
45	negative regulation of protein activation cascade (GO:2000258)	4.81517991
46	bile acid and bile salt transport (GO:0015721)	4.78211797
47	negative regulation of blood coagulation (GO:0030195)	4.75507373
48	negative regulation of hemostasis (GO:1900047)	4.75507373
49	S-adenosylmethionine metabolic process (GO:0046500)	4.70355671
50	regulation of humoral immune response (GO:0002920)	4.68812854
51	tyrosine metabolic process (GO:0006570)	4.63972649
52	positive regulation of triglyceride lipase activity (GO:0061365)	4.50046438
53	positive regulation of lipoprotein lipase activity (GO:0051006)	4.50046438
54	glutamate metabolic process (GO:0006536)	4.49402363
55	triglyceride homeostasis (GO:0070328)	4.42993919
56	acylglycerol homeostasis (GO:0055090)	4.42993919
57	phospholipid efflux (GO:0033700)	4.38975217
58	acute-phase response (GO:0006953)	4.38727516
59	negative regulation of coagulation (GO:0050819)	4.30925549
60	alkaloid metabolic process (GO:0009820)	4.30232677
61	plasma lipoprotein particle remodeling (GO:0034369)	4.27390658
62	protein-lipid complex remodeling (GO:0034368)	4.27390658
63	macromolecular complex remodeling (GO:0034367)	4.27390658
64	alpha-amino acid catabolic process (GO:1901606)	4.25587222
65	negative regulation of wound healing (GO:0061045)	4.25197937
66	cytolysis (GO:0019835)	4.23532463
67	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	4.19724223
68	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	4.19724223
69	serine family amino acid metabolic process (GO:0009069)	4.16650395
70	high-density lipoprotein particle remodeling (GO:0034375)	4.16370654
71	negative regulation of complement activation (GO:0045916)	4.16189222
72	positive regulation of blood coagulation (GO:0030194)	4.16165551
73	positive regulation of hemostasis (GO:1900048)	4.16165551
74	cholesterol efflux (GO:0033344)	4.15681133
75	cellular ketone body metabolic process (GO:0046950)	4.04308144
76	indolalkylamine catabolic process (GO:0046218)	3.99649443
77	tryptophan catabolic process (GO:0006569)	3.99649443
78	indole-containing compound catabolic process (GO:0042436)	3.99649443
79	aromatic amino acid family metabolic process (GO:0009072)	3.99435602
80	flavonoid metabolic process (GO:0009812)	3.99032415
81	arginine metabolic process (GO:0006525)	3.98152541
82	amino-acid betaine metabolic process (GO:0006577)	3.89868053
83	regulation of cholesterol esterification (GO:0010872)	3.85841384
84	reverse cholesterol transport (GO:0043691)	3.82886141
85	positive regulation of coagulation (GO:0050820)	3.78846798
86	hormone catabolic process (GO:0042447)	3.77230546
87	negative regulation of lipase activity (GO:0060192)	3.74782385
88	cellular amino acid catabolic process (GO:0009063)	3.66230925
89	serine family amino acid biosynthetic process (GO:0009070)	3.63463398
90	intestinal cholesterol absorption (GO:0030299)	3.62842253
91	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	3.62576445
92	tryptophan metabolic process (GO:0006568)	3.62526924
93	sodium-independent organic anion transport (GO:0043252)	3.60846603
94	cysteine metabolic process (GO:0006534)	3.60750772
95	ketone body metabolic process (GO:1902224)	3.54404132
96	aldehyde catabolic process (GO:0046185)	3.54062016
97	xenobiotic metabolic process (GO:0006805)	3.53148798
98	plasma lipoprotein particle clearance (GO:0034381)	3.49529278
99	heme transport (GO:0015886)	3.42422951
100	regulation of acute inflammatory response (GO:0002673)	3.37137143

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EGR1_23403033_ChIP-Seq_LIVER_Mouse	7.28533949
2	RXR_22158963_ChIP-Seq_LIVER_Mouse	6.93639209
3	PPARA_22158963_ChIP-Seq_LIVER_Mouse	5.77576106
4	LXR_22158963_ChIP-Seq_LIVER_Mouse	5.54767836
5	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	5.37307723
6	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	4.66916288
7	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	4.32487199
8	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.65440449
9	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	3.55548903
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.00896430
11	HNF4A_19822575_ChIP-Seq_HepG2_Human	2.08975579
12	HTT_18923047_ChIP-ChIP_STHdh_Human	2.04676601
13	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	2.03862679
14	FOXA2_19822575_ChIP-Seq_HepG2_Human	2.01661150
15	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	10.9468882
16	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.99871640
17	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.67976470
18	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.41916880
19	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.40502643
20	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.34885153
21	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.29439330
22	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.22023764
23	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.15783393
24	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.14374241
25	BCAT_22108803_ChIP-Seq_LS180_Human	1.10843494
26	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.04976198
27	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.04550375
28	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.01429791
29	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.99137114
30	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.98259348
31	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.96036146
32	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.95248662
33	* AR_20517297_ChIP-Seq_VCAP_Human	0.94407015
34	PHF8_20622853_ChIP-Seq_HELA_Human	0.88517890
35	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.88366506
36	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.88001897
37	IRF1_19129219_ChIP-ChIP_H3396_Human	0.86861341
38	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.86346434
39	TP53_18474530_ChIP-ChIP_U2OS_Human	0.86178318
40	ER_23166858_ChIP-Seq_MCF-7_Human	0.82882282
41	SOX2_21211035_ChIP-Seq_LN229_Human	0.82067190
42	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.82031479
43	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.80949890
44	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.80639646
45	IGF1R_20145208_ChIP-Seq_DFB_Human	0.79013987
46	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.78907832
47	NFYA_21822215_ChIP-Seq_K562_Human	0.78382748
48	GATA4_25053715_ChIP-Seq_YYC3_Human	0.78273219
49	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.77533165
50	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.77411021
51	* CBP_21632823_ChIP-Seq_H3396_Human	0.76532639
52	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.75243400
53	* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.74316179
54	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.73409515
55	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.73111067
56	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.72844137
57	* FOXA1_25552417_ChIP-Seq_VCAP_Human	0.72801531
58	* CEBPB_22108803_ChIP-Seq_LS180_Human	0.72576937
59	TRIM28_21343339_ChIP-Seq_HEK293_Human	0.72175518
60	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.71229820
61	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.70565908
62	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.69128398
63	P53_21459846_ChIP-Seq_SAOS-2_Human	0.69120982
64	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.67364493
65	RAC3_21632823_ChIP-Seq_H3396_Human	0.66842147
66	ETV1_20927104_ChIP-Seq_GIST48_Human	0.65878912
67	GBX2_23144817_ChIP-Seq_PC3_Human	0.64938949
68	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.64851176
69	* TAF2_19829295_ChIP-Seq_ESCs_Human	0.64391851
70	MYC_19829295_ChIP-Seq_ESCs_Human	0.63789964
71	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.63565868
72	CBP_20019798_ChIP-Seq_JUKART_Human	0.61899794
73	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.61899794
74	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.60476331
75	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.60255684
76	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.59386995
77	NFYB_21822215_ChIP-Seq_K562_Human	0.58219931
78	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.58166229
79	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.58129545
80	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.57836180
81	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.56906459
82	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.56802134
83	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.56565330
84	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.56261445
85	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.55236077
86	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.54212347
87	* ERG_20517297_ChIP-Seq_VCAP_Human	0.54136103
88	* CDX2_22108803_ChIP-Seq_LS180_Human	0.54054236
89	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.53868705
90	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.53619686
91	E2F1_20622854_ChIP-Seq_HELA_Human	0.52701258
92	SPI1_20517297_ChIP-Seq_HL60_Human	0.52218224
93	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.51312808
94	ESRRB_18555785_Chip-Seq_ESCs_Mouse	0.51075578
95	RBPJ_21746931_ChIP-Seq_IB4_Human	0.51044044
96	TCF4_22108803_ChIP-Seq_LS180_Human	0.50920700
97	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.50901995
98	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.50592035
99	MYC_19915707_ChIP-ChIP_AK7_Human	0.50489210
100	SMAD1_18555785_Chip-Seq_ESCs_Mouse	0.50423524

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	9.41125616
2	MP0005360_urolithiasis	6.98309334
3	MP0005085_abnormal_gallbladder_physiolo	6.27329036
4	MP0008875_abnormal_xenobiotic_pharmacok	5.76656771
5	MP0003195_calcinosis	5.37933399
6	MP0005365_abnormal_bile_salt	5.28277228
7	MP0002138_abnormal_hepatobiliary_system	4.93932756
8	MP0003252_abnormal_bile_duct	4.04908306
9	MP0001666_abnormal_nutrient_absorption	3.05035952
10	MP0003868_abnormal_feces_composition	3.01546228
11	MP0010329_abnormal_lipoprotein_level	2.92115370
12	MP0009697_abnormal_copulation	2.92095966
13	MP0005332_abnormal_amino_acid	2.43375200
14	MP0003806_abnormal_nucleotide_metabolis	2.30663327
15	MP0002876_abnormal_thyroid_physiology	2.21216202
16	MP0003191_abnormal_cellular_cholesterol	2.04905689
17	MP0000609_abnormal_liver_physiology	1.77103023
18	MP0010368_abnormal_lymphatic_system	1.73045044
19	MP0009840_abnormal_foam_cell	1.67219761
20	MP0001764_abnormal_homeostasis	1.66532706
21	MP0002118_abnormal_lipid_homeostasis	1.66183247
22	MP0001661_extended_life_span	1.42996405
23	MP0004019_abnormal_vitamin_homeostasis	1.25839360
24	MP0003656_abnormal_erythrocyte_physiolo	1.17211108
25	MP0005408_hypopigmentation	1.10603536
26	MP0005670_abnormal_white_adipose	1.09975910
27	MP0005319_abnormal_enzyme/_coenzyme	1.07734627
28	MP0000598_abnormal_liver_morphology	1.04722077
29	MP0002132_abnormal_respiratory_system	1.04086547
30	MP0009053_abnormal_anal_canal	1.00186789
31	MP0009643_abnormal_urine_homeostasis	0.99427964
32	MP0005584_abnormal_enzyme/coenzyme_acti	0.94955184
33	MP0009764_decreased_sensitivity_to	0.94766975
34	MP0002282_abnormal_trachea_morphology	0.93082058
35	MP0003186_abnormal_redox_activity	0.89780125
36	MP0005451_abnormal_body_composition	0.88305500
37	MP0003690_abnormal_glial_cell	0.84959303
38	MP0009763_increased_sensitivity_to	0.84779292
39	MP0008872_abnormal_physiological_respon	0.83211627
40	MP0002971_abnormal_brown_adipose	0.82728122
41	MP0009642_abnormal_blood_homeostasis	0.82707428
42	MP0005376_homeostasis/metabolism_phenot	0.81888227
43	MP0000604_amyloidosis	0.77428448
44	MP0005636_abnormal_mineral_homeostasis	0.77288096
45	MP0008469_abnormal_protein_level	0.76683406
46	MP0005187_abnormal_penis_morphology	0.76430157
47	MP0001915_intracranial_hemorrhage	0.76055744
48	MP0005535_abnormal_body_temperature	0.75857713
49	MP0005395_other_phenotype	0.75022981
50	MP0003879_abnormal_hair_cell	0.72752777
51	MP0002168_other_aberrant_phenotype	0.67743715
52	MP0002249_abnormal_larynx_morphology	0.65959367
53	MP0005266_abnormal_metabolism	0.65723367
54	MP0003011_delayed_dark_adaptation	0.62827815
55	MP0009780_abnormal_chondrocyte_physiolo	0.60709274
56	MP0002078_abnormal_glucose_homeostasis	0.58394589
57	MP0005334_abnormal_fat_pad	0.58185559
58	MP0003638_abnormal_response/metabolism_	0.57477302
59	MP0004782_abnormal_surfactant_physiolog	0.57336485
60	MP0008874_decreased_physiological_sensi	0.54631701
61	MP0009785_altered_susceptibility_to	0.48556169
62	MP0005464_abnormal_platelet_physiology	0.47660989
63	MP0005166_decreased_susceptibility_to	0.46122598
64	MP0009765_abnormal_xenobiotic_induced	0.44925235
65	MP0006036_abnormal_mitochondrial_physio	0.44222597
66	MP0000566_synostosis	0.43964695
67	MP0005167_abnormal_blood-brain_barrier	0.42947462
68	MP0003075_altered_response_to	0.42702245
69	MP0000249_abnormal_blood_vessel	0.41145371
70	MP0005448_abnormal_energy_balance	0.40827324
71	MP0004130_abnormal_muscle_cell	0.40302888
72	MP0001986_abnormal_taste_sensitivity	0.39067259
73	MP0004883_abnormal_blood_vessel	0.36556380
74	MP0002332_abnormal_exercise_endurance	0.35528337
75	MP0003718_maternal_effect	0.35231508
76	MP0005023_abnormal_wound_healing	0.34616422
77	MP0003953_abnormal_hormone_level	0.31496981
78	MP0005220_abnormal_exocrine_pancreas	0.29449330
79	MP0000639_abnormal_adrenal_gland	0.29272177
80	MP0002136_abnormal_kidney_physiology	0.28842047
81	MP0002928_abnormal_bile_duct	0.28144302
82	MP0001545_abnormal_hematopoietic_system	0.26066443
83	MP0005397_hematopoietic_system_phenotyp	0.26066443
84	MP0005058_abnormal_lysosome_morphology	0.26047381
85	MP0005164_abnormal_response_to	0.25641761
86	MP0002909_abnormal_adrenal_gland	0.24761716
87	MP0001440_abnormal_grooming_behavior	0.23029755
88	MP0009115_abnormal_fat_cell	0.22569218
89	MP0005551_abnormal_eye_electrophysiolog	0.22408208
90	MP0003633_abnormal_nervous_system	0.22346135
91	MP0003632_abnormal_nervous_system	0.20724612
92	MP0000467_abnormal_esophagus_morphology	0.20444748
93	MP0005647_abnormal_sex_gland	0.20217015
94	MP0003631_nervous_system_phenotype	0.18953301
95	MP0005646_abnormal_pituitary_gland	0.18836570
96	MP0001845_abnormal_inflammatory_respons	0.18179922
97	MP0005386_behavior/neurological_phenoty	0.17065472
98	MP0004924_abnormal_behavior	0.17065472
99	MP0001756_abnormal_urination	0.16210341
100	MP0005197_abnormal_uvea_morphology	0.15822729

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Prolonged partial thromboplastin time (HP:0003645)	9.32771847
2	Abnormality of aromatic amino acid family metabolism (HP:0004338)	8.69848533
3	Abnormality of complement system (HP:0005339)	8.04970114
4	Hypobetalipoproteinemia (HP:0003563)	7.10052941
5	Conjugated hyperbilirubinemia (HP:0002908)	6.71539006
6	Joint hemorrhage (HP:0005261)	6.47103690
7	Systemic lupus erythematosus (HP:0002725)	6.34775756
8	Hyperlipoproteinemia (HP:0010980)	5.76179884
9	Glomerulonephritis (HP:0000099)	5.51718043
10	Intrahepatic cholestasis (HP:0001406)	5.24989076
11	Abnormality of pyrimidine metabolism (HP:0004353)	4.99116417
12	Xanthomatosis (HP:0000991)	4.87981028
13	Recurrent gram-negative bacterial infections (HP:0005420)	4.84670847
14	Abnormality of the common coagulation pathway (HP:0010990)	4.29959294
15	Hypolipoproteinemia (HP:0010981)	4.21983675
16	Abnormality of the intrinsic pathway (HP:0010989)	4.09013165
17	Nephritis (HP:0000123)	3.95521426
18	Spontaneous abortion (HP:0005268)	3.93735315
19	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.77252219
20	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	3.75970124
21	Fair hair (HP:0002286)	3.56119438
22	Hypoalphalipoproteinemia (HP:0003233)	3.34114019
23	Abnormality of methionine metabolism (HP:0010901)	3.27322574
24	Hyperglycinemia (HP:0002154)	3.25289882
25	Hyperammonemia (HP:0001987)	3.14411653
26	Neonatal hypoglycemia (HP:0001998)	3.10261863
27	Delayed CNS myelination (HP:0002188)	3.09474779
28	Fat malabsorption (HP:0002630)	3.04825686
29	Hypercholesterolemia (HP:0003124)	2.99755097
30	Abnormality of glycine metabolism (HP:0010895)	2.88961605
31	Abnormality of serine family amino acid metabolism (HP:0010894)	2.88961605
32	Mitral stenosis (HP:0001718)	2.84626049
33	Gingival bleeding (HP:0000225)	2.79188156
34	Generalized aminoaciduria (HP:0002909)	2.77236400
35	Epidermoid cyst (HP:0200040)	2.74256211
36	Abnormality of serum amino acid levels (HP:0003112)	2.69803089
37	Hemorrhage of the eye (HP:0011885)	2.69749788
38	Vascular calcification (HP:0004934)	2.63383277
39	Cholecystitis (HP:0001082)	2.63293695
40	Abnormal gallbladder physiology (HP:0012438)	2.63293695
41	Thrombophlebitis (HP:0004418)	2.61525974
42	Abnormality of nucleobase metabolism (HP:0010932)	2.58257092
43	Hyperbilirubinemia (HP:0002904)	2.58215858
44	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.58096692
45	Rickets (HP:0002748)	2.53653754
46	Pulmonary embolism (HP:0002204)	2.52996632
47	Purpura (HP:0000979)	2.52237714
48	Generalized hypopigmentation of hair (HP:0011358)	2.50519097
49	Osteomalacia (HP:0002749)	2.46552677
50	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.40495483
51	Menorrhagia (HP:0000132)	2.36974170
52	Hyperglycinuria (HP:0003108)	2.32266904
53	Steatorrhea (HP:0002570)	2.31668357
54	Cardiovascular calcification (HP:0011915)	2.30715542
55	Ketosis (HP:0001946)	2.28591170
56	Hepatocellular carcinoma (HP:0001402)	2.25400439
57	Cholelithiasis (HP:0001081)	2.23341577
58	Metabolic acidosis (HP:0001942)	2.22672113
59	Reduced antithrombin III activity (HP:0001976)	2.20585295
60	Abnormal gallbladder morphology (HP:0012437)	2.11178080
61	Blue irides (HP:0000635)	2.04226154
62	Elevated alkaline phosphatase (HP:0003155)	2.03018635
63	Abnormality of monocarboxylic acid metabolism (HP:0010996)	10.5012994
64	Deep venous thrombosis (HP:0002625)	10.0595051
65	Complement deficiency (HP:0004431)	10.0468228
66	Arthropathy (HP:0003040)	1.95416862
67	Abnormal enzyme/coenzyme activity (HP:0012379)	1.93175624
68	Myocardial infarction (HP:0001658)	1.92353625
69	Abnormality of vitamin metabolism (HP:0100508)	1.89706247
70	Abnormality of alkaline phosphatase activity (HP:0004379)	1.88588807
71	Hyperphosphaturia (HP:0003109)	1.88317184
72	Irritability (HP:0000737)	1.88095023
73	Gangrene (HP:0100758)	1.80737123
74	Abnormality of iron homeostasis (HP:0011031)	1.76485132
75	Abnormality of the Achilles tendon (HP:0005109)	1.75212555
76	Abnormal biliary tract physiology (HP:0012439)	1.74932066
77	Bile duct proliferation (HP:0001408)	1.74932066
78	Hypophosphatemic rickets (HP:0004912)	1.74630913
79	Joint swelling (HP:0001386)	1.73367297
80	Cerebral palsy (HP:0100021)	1.72036021
81	Increased mean platelet volume (HP:0011877)	1.71484147
82	Increased serum ferritin (HP:0003281)	1.69388251
83	Lethargy (HP:0001254)	1.67712477
84	Hypochromic microcytic anemia (HP:0004840)	1.67378253
85	Poikilocytosis (HP:0004447)	1.67232866
86	Epistaxis (HP:0000421)	1.65700808
87	Bifid scrotum (HP:0000048)	1.65617162
88	Alkalosis (HP:0001948)	1.64925741
89	Abnormality of transition element cation homeostasis (HP:0011030)	1.64441131
90	Glycosuria (HP:0003076)	1.63832168
91	Abnormality of urine glucose concentration (HP:0011016)	1.63832168
92	Atrioventricular block (HP:0001678)	1.60464118
93	Pancreatitis (HP:0001733)	1.58550906
94	Skin nodule (HP:0200036)	1.57786196
95	Abnormality of the gallbladder (HP:0005264)	1.55571712
96	Cerebral edema (HP:0002181)	1.54181587
97	Abnormal platelet volume (HP:0011876)	1.53676727
98	Abnormality of proline metabolism (HP:0010907)	1.53273849
99	Hydroxyprolinuria (HP:0003080)	1.53273849
100	Reticulocytosis (HP:0001923)	1.51611321

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	4.68574376
2	ERN1	4.43549871
3	BMPR1B	3.78593916
4	PIK3CG	3.42909928
5	GRK1	2.94873679
6	FGFR4	2.92026259
7	CDK8	2.80966894
8	SIK1	2.53077764
9	NTRK3	2.27680779
10	EPHA4	2.26586185
11	PRKACG	2.10395915
12	PIK3CA	2.06790162
13	TNK2	1.93378098
14	TYK2	1.87901186
15	MAP3K3	1.82001944
16	KIT	1.63381948
17	TRIB3	1.62430418
18	TGFBR1	1.58955767
19	INSRR	1.51079391
20	PRKCG	1.46900774
21	NEK9	1.46559356
22	PRKAA2	1.45574224
23	MET	1.43834386
24	RIPK1	1.42829695
25	MAP2K4	1.39614432
26	FRK	1.35874712
27	EPHA3	1.33778928
28	FGFR3	1.28641183
29	TAOK3	1.26126519
30	MAPK11	1.24695510
31	IGF1R	1.21736261
32	ADRBK2	1.20855086
33	AKT3	1.14603986
34	FER	1.12878033
35	DAPK2	1.08126637
36	MUSK	1.03123693
37	ARAF	1.00270173
38	JAK1	0.99526058
39	PRKG1	0.98296957
40	PRKAA1	0.97635670
41	CDK9	0.95547296
42	FLT3	0.95411890
43	PDPK1	0.94960562
44	ERBB2	0.92455747
45	PRKACA	0.90048356
46	ICK	0.89440475
47	ABL2	0.89095294
48	PRKCZ	0.86148641
49	PDK1	0.85549028
50	PRPF4B	0.82581835
51	CAMKK2	0.81370795
52	DYRK1B	0.78446598
53	MAP3K1	0.76937787
54	TBK1	0.76519742
55	CSF1R	0.75995107
56	MST1R	0.72622662
57	MAP3K9	0.72246767
58	SGK1	0.70791013
59	NLK	0.68116549
60	PRKCA	0.65990298
61	PKN2	0.62044666
62	CSNK1D	0.61505895
63	RPS6KA3	0.61464579
64	JAK2	0.57983127
65	TIE1	0.56713069
66	CSNK1E	0.55413151
67	PRKCE	0.54977391
68	MAP3K13	0.52754238
69	PRKCB	0.52116384
70	PRKACB	0.51959821
71	WNK3	0.51357137
72	DYRK1A	0.50643050
73	MAP3K11	0.50212926
74	SGK223	0.49813094
75	SGK494	0.49813094
76	PAK3	0.49307046
77	KDR	0.48866149
78	ERBB3	0.48408409
79	PDK2	0.47563689
80	CAMKK1	0.47404641
81	CSNK1A1	0.45170452
82	CDK7	0.44735901
83	CAMK4	0.42048671
84	SRC	0.41146607
85	TRPM7	0.41032734
86	TAOK2	0.40792939
87	MAP3K2	0.40179322
88	SGK2	0.38949669
89	BCR	0.38497974
90	MAPK4	0.36738132
91	CSNK2A1	0.35815123
92	FGFR2	0.35723846
93	PINK1	0.35493425
94	MYLK	0.34208525
95	CDK6	0.33880773
96	CSNK2A2	0.33716302
97	SGK3	0.33194696
98	MAPK3	0.33091079
99	MAPK10	0.31113900
100	MAPK12	0.30612855

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	4.13636279
2	Caffeine metabolism_Homo sapiens_hsa00232	4.11063477
3	Complement and coagulation cascades_Homo sapiens_hsa04610	4.00456108
4	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.63199854
5	Retinol metabolism_Homo sapiens_hsa00830	3.61032774
6	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.58500801
7	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.46350914
8	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	3.00393488
9	Chemical carcinogenesis_Homo sapiens_hsa05204	2.98435618
10	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.91474271
11	Fatty acid degradation_Homo sapiens_hsa00071	2.73385319
12	Arginine biosynthesis_Homo sapiens_hsa00220	2.65987622
13	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.65680137
14	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.59030115
15	Tyrosine metabolism_Homo sapiens_hsa00350	2.48731792
16	Phenylalanine metabolism_Homo sapiens_hsa00360	2.47878975
17	Drug metabolism - other enzymes_Homo sapiens_hsa00983	2.41601444
18	Histidine metabolism_Homo sapiens_hsa00340	2.19015206
19	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.13581902
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.86470565
21	Butanoate metabolism_Homo sapiens_hsa00650	1.80310135
22	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.75098263
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.73104755
24	Bile secretion_Homo sapiens_hsa04976	1.70768427
25	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.55250880
26	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.53721573
27	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.49379185
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.43131558
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.42508461
30	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.29551713
31	PPAR signaling pathway_Homo sapiens_hsa03320	1.28825621
32	Prion diseases_Homo sapiens_hsa05020	1.26391909
33	Peroxisome_Homo sapiens_hsa04146	1.26092444
34	beta-Alanine metabolism_Homo sapiens_hsa00410	1.22667184
35	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.21513509
36	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.20074499
37	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.14343751
38	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.12974254
39	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.10290138
40	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.06585402
41	Pyruvate metabolism_Homo sapiens_hsa00620	1.03759994
42	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.97436651
43	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.97036122
44	Arginine and proline metabolism_Homo sapiens_hsa00330	0.92159282
45	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.91175732
46	ABC transporters_Homo sapiens_hsa02010	0.83119824
47	One carbon pool by folate_Homo sapiens_hsa00670	0.82735924
48	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.81141228
49	Carbon metabolism_Homo sapiens_hsa01200	0.79711994
50	Propanoate metabolism_Homo sapiens_hsa00640	0.77792718
51	Fat digestion and absorption_Homo sapiens_hsa04975	0.68322926
52	Sulfur metabolism_Homo sapiens_hsa00920	0.66762112
53	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.65083673
54	Fatty acid metabolism_Homo sapiens_hsa01212	0.61925308
55	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.59278696
56	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.55614353
57	Lysine degradation_Homo sapiens_hsa00310	0.44157628
58	Metabolic pathways_Homo sapiens_hsa01100	0.42450633
59	Sulfur relay system_Homo sapiens_hsa04122	0.38774736
60	Pertussis_Homo sapiens_hsa05133	0.37658088
61	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.24747377
62	Glycerolipid metabolism_Homo sapiens_hsa00561	0.23476205
63	Insulin resistance_Homo sapiens_hsa04931	0.21473540
64	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.20432101
65	Glucagon signaling pathway_Homo sapiens_hsa04922	0.20255182
66	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.16797959
67	Pentose phosphate pathway_Homo sapiens_hsa00030	0.16431793
68	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.12822642
69	Mineral absorption_Homo sapiens_hsa04978	0.08130888
70	Fatty acid elongation_Homo sapiens_hsa00062	0.05750803
71	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.04050432
72	Serotonergic synapse_Homo sapiens_hsa04726	0.03176846
73	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.01601072
74	Selenocompound metabolism_Homo sapiens_hsa00450	0.01496802
75	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.01323741
76	AMPK signaling pathway_Homo sapiens_hsa04152	0.01314542
77	Folate biosynthesis_Homo sapiens_hsa00790	0.01257927
78	Glutathione metabolism_Homo sapiens_hsa00480	0.00765233
79	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.00090439
80	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	-0.2788539
81	Sphingolipid metabolism_Homo sapiens_hsa00600	-0.2653834
82	GABAergic synapse_Homo sapiens_hsa04727	-0.2568230
83	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	-0.2420555
84	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	-0.2408274
85	Thyroid hormone synthesis_Homo sapiens_hsa04918	-0.2367554
86	Vascular smooth muscle contraction_Homo sapiens_hsa04270	-0.2208164
87	Ovarian steroidogenesis_Homo sapiens_hsa04913	-0.2023077
88	Glycerophospholipid metabolism_Homo sapiens_hsa00564	-0.1980676
89	Circadian rhythm_Homo sapiens_hsa04710	-0.1894879
90	Type II diabetes mellitus_Homo sapiens_hsa04930	-0.1626714
91	Insulin signaling pathway_Homo sapiens_hsa04910	-0.1437269
92	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	-0.1257485
93	African trypanosomiasis_Homo sapiens_hsa05143	-0.1194355
94	Nitrogen metabolism_Homo sapiens_hsa00910	-0.0936911
95	Galactose metabolism_Homo sapiens_hsa00052	-0.0928881
96	Renin-angiotensin system_Homo sapiens_hsa04614	-0.0856427
97	Amoebiasis_Homo sapiens_hsa05146	-0.0764242
98	Fatty acid biosynthesis_Homo sapiens_hsa00061	-0.0603150
99	Steroid biosynthesis_Homo sapiens_hsa00100	-0.0585674
100	Other glycan degradation_Homo sapiens_hsa00511	-0.0585298

SLC22A10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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