SLC22A11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fucose catabolic process (GO:0019317)4.28334423
2L-fucose metabolic process (GO:0042354)4.28334423
3L-fucose catabolic process (GO:0042355)4.28334423
4response to pheromone (GO:0019236)4.17435959
5water-soluble vitamin biosynthetic process (GO:0042364)4.11753593
6DNA deamination (GO:0045006)3.89851411
7respiratory chain complex IV assembly (GO:0008535)3.83634691
8platelet dense granule organization (GO:0060155)3.68382453
9S-adenosylmethionine metabolic process (GO:0046500)3.64325758
10regulation of glucokinase activity (GO:0033131)3.63688169
11regulation of hexokinase activity (GO:1903299)3.63688169
12behavioral response to nicotine (GO:0035095)3.62089898
13tryptophan catabolic process (GO:0006569)3.60195600
14indole-containing compound catabolic process (GO:0042436)3.60195600
15indolalkylamine catabolic process (GO:0046218)3.60195600
16mannosylation (GO:0097502)3.47770602
17protein K11-linked deubiquitination (GO:0035871)3.45918142
18protein complex biogenesis (GO:0070271)3.42632022
19detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.35893661
20cytochrome complex assembly (GO:0017004)3.32981330
21indolalkylamine metabolic process (GO:0006586)3.30795599
22protein-cofactor linkage (GO:0018065)3.29241035
23detection of light stimulus involved in visual perception (GO:0050908)3.26056565
24detection of light stimulus involved in sensory perception (GO:0050962)3.26056565
25auditory receptor cell stereocilium organization (GO:0060088)3.24604249
26kynurenine metabolic process (GO:0070189)3.23062074
27preassembly of GPI anchor in ER membrane (GO:0016254)3.22697182
28piRNA metabolic process (GO:0034587)3.22185189
29mitochondrial respiratory chain complex assembly (GO:0033108)3.20082761
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.19859141
31mitochondrial respiratory chain complex I assembly (GO:0032981)3.19859141
32NADH dehydrogenase complex assembly (GO:0010257)3.19859141
33epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.11786374
34tryptophan metabolic process (GO:0006568)3.10025404
35cellular ketone body metabolic process (GO:0046950)3.06125203
36gamma-aminobutyric acid transport (GO:0015812)3.01376442
37protein localization to cilium (GO:0061512)3.01003359
38negative regulation of mast cell activation (GO:0033004)2.99140329
39negative regulation of telomere maintenance (GO:0032205)2.96634448
40ketone body metabolic process (GO:1902224)2.92895589
41regulation of cilium movement (GO:0003352)2.92663678
42axoneme assembly (GO:0035082)2.92010189
43GPI anchor metabolic process (GO:0006505)2.90338419
44positive regulation of defense response to virus by host (GO:0002230)2.89506376
45estrogen biosynthetic process (GO:0006703)2.87996796
46reciprocal DNA recombination (GO:0035825)2.85421820
47reciprocal meiotic recombination (GO:0007131)2.85421820
48photoreceptor cell maintenance (GO:0045494)2.81717302
49retinal cone cell development (GO:0046549)2.80817786
50inner ear receptor stereocilium organization (GO:0060122)2.79265728
51cilium morphogenesis (GO:0060271)2.79186734
52adaptation of signaling pathway (GO:0023058)2.75073192
53regulation of memory T cell differentiation (GO:0043380)2.72564692
54cornea development in camera-type eye (GO:0061303)2.72519177
55L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.68012202
56L-methionine salvage (GO:0071267)2.67787137
57L-methionine biosynthetic process (GO:0071265)2.67787137
58amino acid salvage (GO:0043102)2.67787137
59epithelial cilium movement (GO:0003351)2.67277106
60replication fork processing (GO:0031297)2.63792973
61polyol catabolic process (GO:0046174)2.63768439
62protein polyglutamylation (GO:0018095)2.62614198
63negative regulation of transcription regulatory region DNA binding (GO:2000678)2.61758113
64methionine biosynthetic process (GO:0009086)2.60651558
65tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.60409659
66RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.60409659
67mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.60264608
68cellular biogenic amine catabolic process (GO:0042402)2.59516664
69amine catabolic process (GO:0009310)2.59516664
70inositol phosphate catabolic process (GO:0071545)2.59308435
71multicellular organism reproduction (GO:0032504)2.56861069
72meiotic chromosome segregation (GO:0045132)2.56693805
73aromatic amino acid family catabolic process (GO:0009074)2.56415228
74double-strand break repair via homologous recombination (GO:0000724)2.55861234
75positive regulation of mitochondrial fission (GO:0090141)2.55432885
76photoreceptor cell development (GO:0042461)2.54990925
77recombinational repair (GO:0000725)2.54546653
78dopamine transport (GO:0015872)2.52660816
79male meiosis I (GO:0007141)2.50625799
80cilium organization (GO:0044782)2.46778243
81benzene-containing compound metabolic process (GO:0042537)2.46685252
82GPI anchor biosynthetic process (GO:0006506)2.46463263
83kidney morphogenesis (GO:0060993)2.45910490
84positive regulation of glycolytic process (GO:0045821)2.45023115
85basic amino acid transport (GO:0015802)2.44233407
86nonmotile primary cilium assembly (GO:0035058)2.43578689
87indole-containing compound metabolic process (GO:0042430)2.43269327
88DNA methylation involved in gamete generation (GO:0043046)2.40790990
89exogenous drug catabolic process (GO:0042738)2.39694956
90oxidative demethylation (GO:0070989)2.39678608
91fucosylation (GO:0036065)2.39129780
92metallo-sulfur cluster assembly (GO:0031163)2.38860893
93iron-sulfur cluster assembly (GO:0016226)2.38860893
94cilium assembly (GO:0042384)2.38827788
95phosphatidylinositol acyl-chain remodeling (GO:0036149)2.38745056
96positive regulation of fatty acid transport (GO:2000193)2.38720206
97C-terminal protein lipidation (GO:0006501)2.38442191
98eye photoreceptor cell development (GO:0042462)2.38045830
99adenosine metabolic process (GO:0046085)2.37324772
100signal peptide processing (GO:0006465)2.36614392

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.93848648
2VDR_22108803_ChIP-Seq_LS180_Human3.40362539
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.46689275
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.45843026
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40445036
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39378977
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.36874272
8GBX2_23144817_ChIP-Seq_PC3_Human2.35494235
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.35424180
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31931544
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31582640
12IGF1R_20145208_ChIP-Seq_DFB_Human2.19139696
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.17844526
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.07734610
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.05816186
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.05605108
17P300_19829295_ChIP-Seq_ESCs_Human1.93071848
18PCGF2_27294783_Chip-Seq_ESCs_Mouse1.92766767
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92373313
20FUS_26573619_Chip-Seq_HEK293_Human1.89529400
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.84713504
22EWS_26573619_Chip-Seq_HEK293_Human1.84539883
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80979551
24ER_23166858_ChIP-Seq_MCF-7_Human1.80670432
25TAF15_26573619_Chip-Seq_HEK293_Human1.70471237
26TP53_22573176_ChIP-Seq_HFKS_Human1.63311385
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63245962
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62360593
29BCAT_22108803_ChIP-Seq_LS180_Human1.61812126
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.61628388
31CBP_20019798_ChIP-Seq_JUKART_Human1.61628388
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.57916834
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.56541011
34SOX2_19829295_ChIP-Seq_ESCs_Human1.48911602
35NANOG_19829295_ChIP-Seq_ESCs_Human1.48911602
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47878861
37FOXA1_25329375_ChIP-Seq_VCAP_Human1.47431911
38FOXA1_27270436_Chip-Seq_PROSTATE_Human1.47431911
39IRF1_19129219_ChIP-ChIP_H3396_Human1.47125861
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44491078
41VDR_23849224_ChIP-Seq_CD4+_Human1.42203349
42ELK1_19687146_ChIP-ChIP_HELA_Human1.40297209
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40229131
44EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.38517271
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37961472
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.36885964
47GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36191014
48* AR_25329375_ChIP-Seq_VCAP_Human1.36077644
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.35723250
50EGR1_23403033_ChIP-Seq_LIVER_Mouse1.35578252
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.33932571
52AR_20517297_ChIP-Seq_VCAP_Human1.32736920
53MYC_18940864_ChIP-ChIP_HL60_Human1.32095653
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.31170440
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30588979
56TCF4_23295773_ChIP-Seq_U87_Human1.30566432
57TCF4_22108803_ChIP-Seq_LS180_Human1.30430249
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29798899
59FOXA1_21572438_ChIP-Seq_LNCaP_Human1.26266962
60KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24711203
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23166394
62SMAD4_21799915_ChIP-Seq_A2780_Human1.23021757
63* STAT3_23295773_ChIP-Seq_U87_Human1.22818774
64GATA3_21878914_ChIP-Seq_MCF-7_Human1.22460920
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22205757
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22057992
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21612225
68ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19515977
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19082017
70NCOR_22424771_ChIP-Seq_293T_Human1.18673685
71HOXB7_26014856_ChIP-Seq_BT474_Human1.16929264
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15860036
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.15129360
74CDX2_22108803_ChIP-Seq_LS180_Human1.13873509
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13788876
76JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.13346011
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13114825
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13114825
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.12736103
80RUNX2_22187159_ChIP-Seq_PCA_Human1.11868668
81IRF8_22096565_ChIP-ChIP_GC-B_Human1.10181475
82RNF2_27304074_Chip-Seq_NSC_Mouse1.09839789
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08886389
84P53_22387025_ChIP-Seq_ESCs_Mouse1.08290230
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08142020
86FLI1_21867929_ChIP-Seq_TH2_Mouse1.08023719
87STAT3_18555785_Chip-Seq_ESCs_Mouse1.06832343
88CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06522139
89PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06444637
90LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06133530
91HTT_18923047_ChIP-ChIP_STHdh_Human1.06084361
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05103974
93SMAD4_21741376_ChIP-Seq_EPCs_Human1.04248575
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04004672
95FOXP3_21729870_ChIP-Seq_TREG_Human1.03178351
96SMAD3_21741376_ChIP-Seq_EPCs_Human1.02790985
97ETS1_20019798_ChIP-Seq_JURKAT_Human1.00509107
98NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99830137
99FOXH1_21741376_ChIP-Seq_EPCs_Human0.98999403
100PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97507991

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.99553706
2MP0008877_abnormal_DNA_methylation3.30256461
3MP0005646_abnormal_pituitary_gland2.60947039
4MP0000372_irregular_coat_pigmentation2.53406257
5MP0008872_abnormal_physiological_respon2.50309086
6MP0003787_abnormal_imprinting2.40826528
7MP0002876_abnormal_thyroid_physiology2.38517734
8MP0008875_abnormal_xenobiotic_pharmacok2.35454452
9MP0005551_abnormal_eye_electrophysiolog2.35422743
10MP0006072_abnormal_retinal_apoptosis2.21553291
11MP0002102_abnormal_ear_morphology2.14754727
12MP0004147_increased_porphyrin_level2.03218081
13MP0005645_abnormal_hypothalamus_physiol2.00320399
14MP0005253_abnormal_eye_physiology1.98905365
15MP0006292_abnormal_olfactory_placode1.98421406
16MP0005084_abnormal_gallbladder_morpholo1.93400311
17MP0004043_abnormal_pH_regulation1.92670950
18MP0000569_abnormal_digit_pigmentation1.86972778
19MP0003011_delayed_dark_adaptation1.86559436
20MP0002837_dystrophic_cardiac_calcinosis1.85034061
21MP0002938_white_spotting1.84416487
22MP0008995_early_reproductive_senescence1.71505877
23MP0009046_muscle_twitch1.67241835
24MP0001968_abnormal_touch/_nociception1.66008150
25MP0001501_abnormal_sleep_pattern1.62703360
26MP0001986_abnormal_taste_sensitivity1.60768132
27MP0004133_heterotaxia1.59169469
28MP0001984_abnormal_olfaction1.55749193
29MP0009697_abnormal_copulation1.52076191
30MP0008058_abnormal_DNA_repair1.49249225
31MP0000427_abnormal_hair_cycle1.49246247
32MP0002736_abnormal_nociception_after1.47388364
33MP0005075_abnormal_melanosome_morpholog1.45955711
34MP0000631_abnormal_neuroendocrine_gland1.42952673
35MP0004142_abnormal_muscle_tone1.40773156
36MP0001764_abnormal_homeostasis1.36132688
37MP0005332_abnormal_amino_acid1.30046241
38MP0002909_abnormal_adrenal_gland1.29514514
39MP0003646_muscle_fatigue1.27218674
40MP0002272_abnormal_nervous_system1.26260206
41MP0002138_abnormal_hepatobiliary_system1.25771415
42MP0005389_reproductive_system_phenotype1.25728525
43MP0003878_abnormal_ear_physiology1.25494087
44MP0005377_hearing/vestibular/ear_phenot1.25494087
45MP0002928_abnormal_bile_duct1.25490310
46MP0002163_abnormal_gland_morphology1.24749065
47MP0009745_abnormal_behavioral_response1.24268288
48MP0005379_endocrine/exocrine_gland_phen1.22291378
49MP0002653_abnormal_ependyma_morphology1.21416547
50MP0006276_abnormal_autonomic_nervous1.20649526
51MP0003718_maternal_effect1.20448208
52MP0003786_premature_aging1.19336369
53MP0003252_abnormal_bile_duct1.18795603
54MP0000383_abnormal_hair_follicle1.17214563
55MP0001919_abnormal_reproductive_system1.16554347
56MP0002557_abnormal_social/conspecific_i1.14950162
57MP0005365_abnormal_bile_salt1.14931277
58MP0005410_abnormal_fertilization1.14059435
59MP0002638_abnormal_pupillary_reflex1.13709357
60MP0003283_abnormal_digestive_organ1.13395852
61MP0005636_abnormal_mineral_homeostasis1.13169443
62MP0004885_abnormal_endolymph1.12870938
63MP0010329_abnormal_lipoprotein_level1.12825289
64MP0000647_abnormal_sebaceous_gland1.11651015
65MP0005085_abnormal_gallbladder_physiolo1.03521288
66MP0002160_abnormal_reproductive_system1.03483360
67MP0001485_abnormal_pinna_reflex1.02751252
68MP0003880_abnormal_central_pattern1.02396307
69MP0002254_reproductive_system_inflammat1.02255527
70MP0002234_abnormal_pharynx_morphology1.02214712
71MP0001486_abnormal_startle_reflex1.00259385
72MP0001756_abnormal_urination0.98189778
73MP0010386_abnormal_urinary_bladder0.97498252
74MP0005174_abnormal_tail_pigmentation0.96991205
75MP0004019_abnormal_vitamin_homeostasis0.95899346
76MP0006036_abnormal_mitochondrial_physio0.95717310
77MP0003121_genomic_imprinting0.94045239
78MP0009780_abnormal_chondrocyte_physiolo0.93843759
79MP0000639_abnormal_adrenal_gland0.93430911
80MP0002693_abnormal_pancreas_physiology0.92903231
81MP0001324_abnormal_eye_pigmentation0.91906113
82MP0002735_abnormal_chemical_nociception0.90607964
83MP0003122_maternal_imprinting0.90159425
84MP0002572_abnormal_emotion/affect_behav0.89899252
85MP0003698_abnormal_male_reproductive0.86607554
86MP0001944_abnormal_pancreas_morphology0.86098779
87MP0008789_abnormal_olfactory_epithelium0.85167791
88MP0001970_abnormal_pain_threshold0.84616928
89MP0001929_abnormal_gametogenesis0.84157796
90MP0004742_abnormal_vestibular_system0.82127771
91MP0005195_abnormal_posterior_eye0.78824529
92MP0002733_abnormal_thermal_nociception0.77068026
93MP0002064_seizures0.77052228
94MP0005386_behavior/neurological_phenoty0.76893727
95MP0004924_abnormal_behavior0.76893727
96MP0002095_abnormal_skin_pigmentation0.76651414
97MP0001905_abnormal_dopamine_level0.76330888
98MP0005367_renal/urinary_system_phenotyp0.76118199
99MP0000516_abnormal_urinary_system0.76118199
100MP0009643_abnormal_urine_homeostasis0.76085952

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.23337780
2Pancreatic fibrosis (HP:0100732)3.84687220
3True hermaphroditism (HP:0010459)3.73486036
4Abnormality of midbrain morphology (HP:0002418)3.56762428
5Molar tooth sign on MRI (HP:0002419)3.56762428
6Congenital stationary night blindness (HP:0007642)3.50314809
7Nephronophthisis (HP:0000090)3.36033907
8Type II lissencephaly (HP:0007260)3.28136136
9Abnormality of the renal cortex (HP:0011035)3.23732868
10Abnormality of the renal medulla (HP:0100957)3.05317472
11Attenuation of retinal blood vessels (HP:0007843)2.94422283
12Abnormal drinking behavior (HP:0030082)2.90338652
13Polydipsia (HP:0001959)2.90338652
14Hypomagnesemia (HP:0002917)2.89902084
15Medial flaring of the eyebrow (HP:0010747)2.88128555
16Hypothermia (HP:0002045)2.83125298
17Abnormal rod and cone electroretinograms (HP:0008323)2.82595355
18Renal cortical cysts (HP:0000803)2.75846238
19Abolished electroretinogram (ERG) (HP:0000550)2.73856508
20Hepatocellular necrosis (HP:0001404)2.71584589
21Hyperventilation (HP:0002883)2.70748194
22Mitochondrial inheritance (HP:0001427)2.67629605
23Cerebellar dysplasia (HP:0007033)2.66709875
24Tubular atrophy (HP:0000092)2.62259052
25Increased CSF lactate (HP:0002490)2.61952462
26Hepatic necrosis (HP:0002605)2.60223867
27Cystic liver disease (HP:0006706)2.53338282
28Methylmalonic acidemia (HP:0002912)2.51554733
29Polyuria (HP:0000103)2.49711067
30Acute necrotizing encephalopathy (HP:0006965)2.42635482
31Abnormality of macular pigmentation (HP:0008002)2.31048681
32Pendular nystagmus (HP:0012043)2.30252443
33Progressive macrocephaly (HP:0004481)2.29687909
34Gait imbalance (HP:0002141)2.29154287
35Absent rod-and cone-mediated responses on ERG (HP:0007688)2.29117276
36Increased corneal curvature (HP:0100692)2.28438103
37Keratoconus (HP:0000563)2.28438103
38Chronic hepatic failure (HP:0100626)2.28205544
39Congenital primary aphakia (HP:0007707)2.27298200
40Acute encephalopathy (HP:0006846)2.27164927
41Nephrogenic diabetes insipidus (HP:0009806)2.26563744
42Abnormal mitochondria in muscle tissue (HP:0008316)2.26323745
43Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.24856821
44Abnormality of alanine metabolism (HP:0010916)2.24856821
45Hyperalaninemia (HP:0003348)2.24856821
46Methylmalonic aciduria (HP:0012120)2.24032845
47Bile duct proliferation (HP:0001408)2.19846326
48Abnormal biliary tract physiology (HP:0012439)2.19846326
49Decreased central vision (HP:0007663)2.19297561
50Progressive inability to walk (HP:0002505)2.18063094
51Ketoacidosis (HP:0001993)2.17999114
52Lipid accumulation in hepatocytes (HP:0006561)2.15652370
53Abnormality of the pons (HP:0007361)2.14490797
54Intestinal atresia (HP:0011100)2.12190285
55Inability to walk (HP:0002540)2.11138289
56Congenital hepatic fibrosis (HP:0002612)2.09927829
57Hypokalemic alkalosis (HP:0001949)2.09451966
58Decreased electroretinogram (ERG) amplitude (HP:0000654)2.06358991
59Hyperglycinuria (HP:0003108)2.06270945
60Hypoplasia of the pons (HP:0012110)2.04990150
61Genital tract atresia (HP:0001827)2.04476809
62Sclerocornea (HP:0000647)2.03421441
633-Methylglutaconic aciduria (HP:0003535)2.01502731
64Abnormal urine output (HP:0012590)1.99865945
65Increased hepatocellular lipid droplets (HP:0006565)1.99837761
66Aplasia/Hypoplasia of the tongue (HP:0010295)1.99101447
67Abnormality of the labia minora (HP:0012880)1.97680079
68Large for gestational age (HP:0001520)1.95926608
69Thyroiditis (HP:0100646)1.94643280
70Aplasia/Hypoplasia of the spleen (HP:0010451)1.93860915
71Abnormality of magnesium homeostasis (HP:0004921)1.92907989
72Aplasia/Hypoplasia of the tibia (HP:0005772)1.92693029
73Ketosis (HP:0001946)1.91480475
74Stomatitis (HP:0010280)1.91370467
75Optic disc pallor (HP:0000543)1.90049432
76Postaxial foot polydactyly (HP:0001830)1.90011920
77Increased serum lactate (HP:0002151)1.89896954
78Vaginal atresia (HP:0000148)1.89886409
79Hemiparesis (HP:0001269)1.88876020
80Anencephaly (HP:0002323)1.88854772
81Lissencephaly (HP:0001339)1.87258563
82Increased circulating renin level (HP:0000848)1.86812690
83Chorioretinal atrophy (HP:0000533)1.86693716
84Asplenia (HP:0001746)1.86335044
85Abnormality of vitamin B metabolism (HP:0004340)1.86285942
86Furrowed tongue (HP:0000221)1.85490349
87Male pseudohermaphroditism (HP:0000037)1.84685878
88Aplasia/hypoplasia of the uterus (HP:0008684)1.83829351
89Tetany (HP:0001281)1.82588052
90Gaze-evoked nystagmus (HP:0000640)1.80005571
91Hyperglycinemia (HP:0002154)1.79760501
92Bony spicule pigmentary retinopathy (HP:0007737)1.79012004
93Short tibia (HP:0005736)1.78688988
94Stomach cancer (HP:0012126)1.76122087
95Abnormality of glycine metabolism (HP:0010895)1.74657004
96Abnormality of serine family amino acid metabolism (HP:0010894)1.74657004
97Abnormality of renal excretion (HP:0011036)1.74403061
98Constricted visual fields (HP:0001133)1.71800172
99Concave nail (HP:0001598)1.70465598
100CNS demyelination (HP:0007305)1.70374406

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.80433039
2ZAK3.20355223
3INSRR3.02037188
4WNK32.83693487
5MAP4K22.77388966
6WNK42.56074520
7ADRBK22.50063117
8NUAK12.48925029
9TAOK32.39525438
10BMPR1B2.35980961
11OXSR12.28180352
12STK392.23950948
13GRK12.07486221
14PINK11.98756128
15TRIM281.82308032
16TLK11.77199350
17NME11.75342363
18DAPK21.73347202
19MST41.46350539
20MAPK131.45094345
21STK38L1.42743506
22TNIK1.42171069
23PAK31.30918519
24CASK1.29545139
25VRK21.22930579
26FER1.19907314
27TXK1.18631454
28EIF2AK31.16142299
29VRK11.13875297
30MAP3K41.13078500
31ACVR1B1.12703329
32FGFR21.08127676
33CSNK1G11.07857826
34PRKCE1.03556468
35PLK21.00585338
36CSNK1G31.00258742
37ERBB30.98933947
38BCKDK0.97819203
39PLK40.93958274
40BRSK20.93811563
41CSNK1G20.93042307
42PHKG20.90223793
43PHKG10.90223793
44PLK30.88117232
45MKNK20.86922315
46LATS10.86060686
47FLT30.82862568
48CSNK1A1L0.82861468
49DYRK20.80867843
50ADRBK10.80433961
51STK30.78072997
52TNK20.76381029
53MKNK10.76280301
54IKBKB0.76214450
55PRKCG0.73831640
56KIT0.71456906
57PRKCI0.71187341
58PRKCQ0.69536723
59PKN10.68871300
60NTRK30.67702345
61BCR0.67508185
62MUSK0.66833441
63FES0.65047922
64TEC0.63150228
65RPS6KA50.62287630
66CAMKK20.61507042
67DAPK10.58995631
68MAP2K60.58011202
69PTK2B0.57874042
70MAP2K70.56954517
71MAPKAPK30.52424686
72CSNK1A10.51918634
73NLK0.51165597
74STK160.50899491
75WEE10.48533384
76RPS6KA40.46388333
77TIE10.44456233
78ITK0.43010602
79CSNK1D0.42095517
80PRKACA0.41900254
81ATR0.40990308
82CAMK2A0.40632421
83PRKCA0.39731513
84MAPKAPK50.39379672
85BMPR20.39373578
86TAF10.36136446
87ABL10.35561372
88EIF2AK20.35374833
89PDK20.33040375
90IRAK10.31565547
91EPHA40.31077123
92SYK0.30420519
93PIK3CA0.30229368
94DYRK1A0.29853299
95CAMK10.29535612
96PLK10.29388916
97MAP3K120.28503349
98MARK10.27921158
99PRKCZ0.27852585
100STK380.27157397

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049502.81298663
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.80831243
3Butanoate metabolism_Homo sapiens_hsa006502.71429740
4Protein export_Homo sapiens_hsa030602.45446283
5Oxidative phosphorylation_Homo sapiens_hsa001902.29876882
6Phototransduction_Homo sapiens_hsa047442.29395706
7Linoleic acid metabolism_Homo sapiens_hsa005912.28777789
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.27454637
9Homologous recombination_Homo sapiens_hsa034402.13486160
10Caffeine metabolism_Homo sapiens_hsa002322.12920081
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.04450509
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.03379133
13Selenocompound metabolism_Homo sapiens_hsa004502.03310444
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.95066532
15One carbon pool by folate_Homo sapiens_hsa006701.90763746
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.89789327
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.88665905
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82506167
19Nitrogen metabolism_Homo sapiens_hsa009101.79799234
20Propanoate metabolism_Homo sapiens_hsa006401.78252507
21Tryptophan metabolism_Homo sapiens_hsa003801.73479670
22Proteasome_Homo sapiens_hsa030501.67287689
23Parkinsons disease_Homo sapiens_hsa050121.61072973
24RNA polymerase_Homo sapiens_hsa030201.58510159
25Fanconi anemia pathway_Homo sapiens_hsa034601.55925600
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.51576034
27Basal transcription factors_Homo sapiens_hsa030221.47072201
28Ether lipid metabolism_Homo sapiens_hsa005651.46065127
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44236046
30Peroxisome_Homo sapiens_hsa041461.43738089
31Collecting duct acid secretion_Homo sapiens_hsa049661.43392703
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.42133634
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.33283905
34Chemical carcinogenesis_Homo sapiens_hsa052041.29661684
35Primary immunodeficiency_Homo sapiens_hsa053401.26584101
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26199435
37Non-homologous end-joining_Homo sapiens_hsa034501.22548366
38Retinol metabolism_Homo sapiens_hsa008301.18507513
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.16309697
40Fatty acid elongation_Homo sapiens_hsa000621.11549320
41Steroid biosynthesis_Homo sapiens_hsa001001.06538965
42RNA degradation_Homo sapiens_hsa030181.05321403
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.04140357
44Arachidonic acid metabolism_Homo sapiens_hsa005901.01976253
45ABC transporters_Homo sapiens_hsa020101.00711200
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97227261
47Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96685176
48Intestinal immune network for IgA production_Homo sapiens_hsa046720.95431136
49Olfactory transduction_Homo sapiens_hsa047400.94117715
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93722809
51Huntingtons disease_Homo sapiens_hsa050160.91381015
52Sulfur metabolism_Homo sapiens_hsa009200.89200045
53Regulation of autophagy_Homo sapiens_hsa041400.88740860
54Nicotine addiction_Homo sapiens_hsa050330.88226498
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87372391
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.84648825
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84352074
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82607220
59Alzheimers disease_Homo sapiens_hsa050100.82274851
60Ovarian steroidogenesis_Homo sapiens_hsa049130.81314488
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80271006
62beta-Alanine metabolism_Homo sapiens_hsa004100.80095993
63Metabolic pathways_Homo sapiens_hsa011000.80063207
64Folate biosynthesis_Homo sapiens_hsa007900.78961700
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78942476
66Taste transduction_Homo sapiens_hsa047420.78909199
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78189075
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.77625207
69Purine metabolism_Homo sapiens_hsa002300.77316160
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74609590
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72557916
72Insulin secretion_Homo sapiens_hsa049110.71780021
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69749019
74Asthma_Homo sapiens_hsa053100.68254418
75Fat digestion and absorption_Homo sapiens_hsa049750.67593433
76Type I diabetes mellitus_Homo sapiens_hsa049400.66804336
77Glutathione metabolism_Homo sapiens_hsa004800.65194297
78Mineral absorption_Homo sapiens_hsa049780.62999849
79Fatty acid metabolism_Homo sapiens_hsa012120.58118003
80Histidine metabolism_Homo sapiens_hsa003400.56949837
81Pyrimidine metabolism_Homo sapiens_hsa002400.54647000
82Rheumatoid arthritis_Homo sapiens_hsa053230.53622877
83Cardiac muscle contraction_Homo sapiens_hsa042600.53260920
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52954325
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51731780
86Fatty acid degradation_Homo sapiens_hsa000710.51089231
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50271179
88Vitamin digestion and absorption_Homo sapiens_hsa049770.49889423
89Base excision repair_Homo sapiens_hsa034100.47776493
90Morphine addiction_Homo sapiens_hsa050320.47718293
91Sulfur relay system_Homo sapiens_hsa041220.42935236
92Arginine and proline metabolism_Homo sapiens_hsa003300.41139564
93GABAergic synapse_Homo sapiens_hsa047270.40398816
94Salivary secretion_Homo sapiens_hsa049700.37121348
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.34015220
96Glycerolipid metabolism_Homo sapiens_hsa005610.33812139
97N-Glycan biosynthesis_Homo sapiens_hsa005100.33335793
98Serotonergic synapse_Homo sapiens_hsa047260.32373401
99Nucleotide excision repair_Homo sapiens_hsa034200.31227376
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30985246

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