SLC22A12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transport (GO:0015893)9.24941839
2* urate metabolic process (GO:0046415)9.23940443
3collecting duct development (GO:0072044)9.16798347
4organic cation transport (GO:0015695)8.81230500
5phosphate ion transport (GO:0006817)8.54849636
6lysine catabolic process (GO:0006554)8.06828903
7lysine metabolic process (GO:0006553)8.06828903
8actin filament depolymerization (GO:0030042)8.01794576
9exogenous drug catabolic process (GO:0042738)7.61292581
10drug catabolic process (GO:0042737)7.51389444
11quaternary ammonium group transport (GO:0015697)7.14389852
12phosphate ion transmembrane transport (GO:0035435)7.09985990
13glyoxylate metabolic process (GO:0046487)6.93448426
14cysteine metabolic process (GO:0006534)6.72413316
15cardiovascular system development (GO:0072358)6.37183761
16nephron tubule formation (GO:0072079)6.28647872
17response to mercury ion (GO:0046689)6.18646090
18regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033396.14710069
19tricarboxylic acid metabolic process (GO:0072350)6.12622425
20nonribosomal peptide biosynthetic process (GO:0019184)6.08344600
21response to water (GO:0009415)5.88112431
22excretion (GO:0007588)5.83425228
23vitamin D metabolic process (GO:0042359)5.79603095
24negative regulation of metanephros development (GO:0072217)5.70522816
25toxin transport (GO:1901998)5.61548704
26cell volume homeostasis (GO:0006884)5.57628670
27short-chain fatty acid metabolic process (GO:0046459)5.54907657
28glutathione biosynthetic process (GO:0006750)5.48992164
29renal absorption (GO:0070293)5.45443746
30aspartate family amino acid catabolic process (GO:0009068)5.44662203
31positive regulation of catenin import into nucleus (GO:0035413)5.39119111
32branched-chain amino acid metabolic process (GO:0009081)5.29298991
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.23483343
34metanephric nephron tubule development (GO:0072234)5.21501673
35metanephric tubule development (GO:0072170)5.21501673
36trivalent inorganic anion homeostasis (GO:0072506)5.21380809
37phosphate ion homeostasis (GO:0055062)5.21380809
38amino-acid betaine transport (GO:0015838)5.10636536
39carnitine transport (GO:0015879)5.10636536
40activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)5.07444109
41positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc5.06112127
42negative regulation of sterol transport (GO:0032372)5.05920596
43negative regulation of cholesterol transport (GO:0032375)5.05920596
44positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)5.02830151
45glycoside metabolic process (GO:0016137)4.93933154
46L-phenylalanine metabolic process (GO:0006558)4.88337729
47erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.88337729
48valine metabolic process (GO:0006573)4.87570966
49homocysteine metabolic process (GO:0050667)4.84597100
50erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.83274031
51L-phenylalanine catabolic process (GO:0006559)4.83274031
52regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.81993130
53metanephric nephron epithelium development (GO:0072243)4.80066884
54regulation of apoptotic process involved in morphogenesis (GO:1902337)4.75766088
55modified amino acid transport (GO:0072337)4.74284074
56mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.72542703
57serine family amino acid catabolic process (GO:0009071)4.71797843
58serine family amino acid metabolic process (GO:0009069)4.71170120
59cellular modified amino acid catabolic process (GO:0042219)4.70006652
60proline metabolic process (GO:0006560)4.65440158
61aromatic amino acid family catabolic process (GO:0009074)4.64019149
62response to thyroid hormone (GO:0097066)4.61514584
63amino-acid betaine metabolic process (GO:0006577)4.49869423
64indole-containing compound catabolic process (GO:0042436)4.43483986
65indolalkylamine catabolic process (GO:0046218)4.43483986
66tryptophan catabolic process (GO:0006569)4.43483986
67fatty acid beta-oxidation (GO:0006635)4.40555057
68peptide biosynthetic process (GO:0043043)4.40019325
69metanephric epithelium development (GO:0072207)4.38732077
70response to vitamin A (GO:0033189)4.34933499
71branched-chain amino acid catabolic process (GO:0009083)4.30948596
722-oxoglutarate metabolic process (GO:0006103)4.27220419
73fructose metabolic process (GO:0006000)4.26083731
74tryptophan metabolic process (GO:0006568)4.25480860
75pattern specification involved in kidney development (GO:0061004)4.19905454
76nephron tubule development (GO:0072080)4.17148757
77response to copper ion (GO:0046688)4.16790584
78positive regulation of glomerulus development (GO:0090193)4.10631540
79carnitine metabolic process (GO:0009437)4.10173565
80cellular ketone body metabolic process (GO:0046950)4.07420114
81sodium-independent organic anion transport (GO:0043252)4.06941129
82oligosaccharide catabolic process (GO:0009313)4.06055207
83bone remodeling (GO:0046849)4.06032181
84peptide catabolic process (GO:0043171)4.03939722
85fatty acid oxidation (GO:0019395)4.03822315
86hyperosmotic response (GO:0006972)4.01765213
87acetyl-CoA metabolic process (GO:0006084)3.97294414
88lipid oxidation (GO:0034440)3.96272124
89negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.93802699
90serine family amino acid biosynthetic process (GO:0009070)3.88365043
91response to parathyroid hormone (GO:0071107)3.85577877
92response to phenylpropanoid (GO:0080184)3.80322873
93NADH metabolic process (GO:0006734)3.79143075
94glutathione metabolic process (GO:0006749)3.76802142
95glutamate metabolic process (GO:0006536)3.74629672
96response to growth hormone (GO:0060416)3.73664517
97cellular amino acid catabolic process (GO:0009063)3.72975310
98renal system process (GO:0003014)3.70841833
99renal tubule development (GO:0061326)3.70264790
100vitamin transport (GO:0051180)3.66136985
101inositol metabolic process (GO:0006020)3.64386696
102urogenital system development (GO:0001655)3.64044943
103fatty acid catabolic process (GO:0009062)3.62923610
104cell differentiation involved in metanephros development (GO:0072202)3.61877928
105alpha-amino acid catabolic process (GO:1901606)3.58926924
106regulation of protein localization to cell surface (GO:2000008)3.58013770
107drug metabolic process (GO:0017144)3.57785895
108cellular response to ammonium ion (GO:0071242)3.56040084
109regulation of cholesterol efflux (GO:0010874)3.54996696
110indole-containing compound metabolic process (GO:0042430)3.54819476
111glutathione derivative biosynthetic process (GO:1901687)3.52951622
112glutathione derivative metabolic process (GO:1901685)3.52951622
113ketone body metabolic process (GO:1902224)3.50312487
114beta-amyloid metabolic process (GO:0050435)3.49670589
115aromatic amino acid family metabolic process (GO:0009072)3.44616928
116cellular response to vitamin D (GO:0071305)3.44204260
117organic acid catabolic process (GO:0016054)3.41487822
118carboxylic acid catabolic process (GO:0046395)3.41487822
119nephron tubule morphogenesis (GO:0072078)3.41155852
120nephron epithelium morphogenesis (GO:0072088)3.41155852
121monocarboxylic acid catabolic process (GO:0072329)3.41032275
122sulfur amino acid catabolic process (GO:0000098)3.40505340
123nephron epithelium development (GO:0072009)3.37097323
124sulfur compound transport (GO:0072348)3.34141893
125pyrimidine ribonucleoside catabolic process (GO:0046133)3.31617727
126response to magnesium ion (GO:0032026)3.30207843
127sodium ion transport (GO:0006814)3.26711501
128response to lead ion (GO:0010288)3.24777956
129mammary gland alveolus development (GO:0060749)3.24677285
130dicarboxylic acid metabolic process (GO:0043648)3.24664270
131tricarboxylic acid cycle (GO:0006099)3.23873332
132response to salt stress (GO:0009651)3.21821870
133mesonephros development (GO:0001823)3.19384090
134negative regulation of kidney development (GO:0090185)3.16581729
135positive regulation of metanephros development (GO:0072216)3.10067203
136regulation of potassium ion transmembrane transporter activity (GO:1901016)3.03289589
137positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.02985704
138regulation of fever generation (GO:0031620)3.02312221
139regulation of mesenchymal cell apoptotic process (GO:2001053)2.97561403
140metanephric mesenchyme development (GO:0072075)2.96717920
141regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.96661670
142glomerular visceral epithelial cell development (GO:0072015)2.95467606
143one-carbon compound transport (GO:0019755)2.95341584
144positive regulation of heat generation (GO:0031652)2.94294947
145ERK1 and ERK2 cascade (GO:0070371)2.93535768
146response to lithium ion (GO:0010226)2.92305285
147water transport (GO:0006833)2.89495100
148regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.87614621
149regulation of anion transport (GO:0044070)2.87240124
150regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:22.84656320
151regulation of metanephros development (GO:0072215)2.84066412
152regulation of catenin import into nucleus (GO:0035412)2.73963294
153neurotransmitter biosynthetic process (GO:0042136)2.72201820
154positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.68127904
155inorganic anion transport (GO:0015698)2.65377771
156regulation of stem cell maintenance (GO:2000036)2.64593953
157glycine metabolic process (GO:0006544)2.64501095
158S-adenosylmethionine metabolic process (GO:0046500)2.64372675
159protein depolymerization (GO:0051261)2.63327168
160negative regulation of lipid transport (GO:0032369)2.63177699
161regulation of glomerulus development (GO:0090192)2.63038078
162positive regulation of peptidyl-threonine phosphorylation (GO:0010800)2.62986917
163oxaloacetate metabolic process (GO:0006107)2.62733476
164polyol transport (GO:0015791)11.4894532
165drug transmembrane transport (GO:0006855)11.0808101
166aminoglycoside antibiotic metabolic process (GO:0030647)11.0020572

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.34868080
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.30359330
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.50404537
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.11546866
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.85286087
6ESR1_21235772_ChIP-Seq_MCF-7_Human3.72912757
7EZH2_22144423_ChIP-Seq_EOC_Human3.66865151
8HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.86514609
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.78396347
10CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.60594634
11ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.60149912
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.55127804
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.37385523
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.34830454
15AR_21909140_ChIP-Seq_LNCAP_Human2.32967554
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.30886979
17CDX2_20551321_ChIP-Seq_CACO-2_Human2.25791837
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.19706525
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.15291515
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.04345977
21CLOCK_20551151_ChIP-Seq_293T_Human2.02471171
22TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.98329317
23EGR1_23403033_ChIP-Seq_LIVER_Mouse1.85100668
24TCF4_18268006_ChIP-ChIP_LS174T_Human1.84830749
25FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.82292122
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.80781234
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.78912653
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.78347449
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.75493730
30ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.74041980
31NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.66968389
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.66591673
33HNF4A_19822575_ChIP-Seq_HepG2_Human1.66119507
34VDR_22108803_ChIP-Seq_LS180_Human1.63634177
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.57441977
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.54402316
37SOX2_27498859_Chip-Seq_STOMACH_Mouse1.54294770
38RNF2_18974828_ChIP-Seq_MESCs_Mouse1.51408227
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.51408227
40* EZH2_27294783_Chip-Seq_ESCs_Mouse1.51323285
41ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.50137964
42LXR_22292898_ChIP-Seq_THP-1_Human1.49798451
43GATA4_25053715_ChIP-Seq_YYC3_Human1.48173341
44FOXA2_19822575_ChIP-Seq_HepG2_Human1.47871153
45GBX2_23144817_ChIP-Seq_PC3_Human1.46544197
46SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.46458069
47STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.45037366
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.42218082
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40614168
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40081952
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.37943928
52* EZH2_27304074_Chip-Seq_ESCs_Mouse1.36223178
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34326279
54FOXO3_23340844_ChIP-Seq_DLD1_Human1.33318264
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.33140253
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31599615
57PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.31423452
58RACK7_27058665_Chip-Seq_MCF-7_Human1.31402888
59EGR1_19032775_ChIP-ChIP_M12_Human1.30366679
60AR_21572438_ChIP-Seq_LNCaP_Human1.25618050
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22843115
62TP53_20018659_ChIP-ChIP_R1E_Mouse1.21536424
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.20531323
64SMAD3_21741376_ChIP-Seq_HESCs_Human1.20392831
65P53_22127205_ChIP-Seq_FIBROBLAST_Human1.20204421
66GATA6_25053715_ChIP-Seq_YYC3_Human1.18115159
67SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17778967
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16922499
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16626904
70TBX20_22328084_ChIP-Seq_HEART_Mouse1.16572940
71TBX20_22080862_ChIP-Seq_HEART_Mouse1.16572940
72TCF4_22108803_ChIP-Seq_LS180_Human1.15434179
73PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15229270
74RXR_22108803_ChIP-Seq_LS180_Human1.09941301
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.09246635
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08971800
77KLF4_18555785_Chip-Seq_ESCs_Mouse1.08072373
78ELK4_26923725_Chip-Seq_MESODERM_Mouse1.07372570
79* SMAD4_21799915_ChIP-Seq_A2780_Human1.06855792
80FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06759996
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.05800429
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04399624
83P300_19829295_ChIP-Seq_ESCs_Human1.04100303
84E2F1_18555785_Chip-Seq_ESCs_Mouse1.03785288
85CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.02864554
86RING1B_27294783_Chip-Seq_ESCs_Mouse1.02607441
87TBL1_22424771_ChIP-Seq_293T_Human1.01125544
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01038113
89* DROSHA_22980978_ChIP-Seq_HELA_Human1.00880757
90CBX2_27304074_Chip-Seq_ESCs_Mouse1.00530149
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00244058
92AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00149765
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99806383
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99796286
95* CBP_21632823_ChIP-Seq_H3396_Human0.99033338
96PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98790163
97BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98695048
98PHF8_20622853_ChIP-Seq_HELA_Human0.97735622
99SOX11_22085726_ChIP-Seq_ESNs_Mouse0.97117967
100STAT3_18555785_Chip-Seq_ESCs_Mouse0.96345816
101* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96334520
102RING1B_27294783_Chip-Seq_NPCs_Mouse0.96239522
103ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96123062
104ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95751884
105STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95642737
106AHR_22903824_ChIP-Seq_MCF-7_Human0.94683083
107NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94469058
108* KDM2B_26808549_Chip-Seq_REH_Human0.94442432
109ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93061896
110PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92619176
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91753691
112NFYA_21822215_ChIP-Seq_K562_Human0.91303635
113SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90985531
114SOX2_20726797_ChIP-Seq_SW620_Human0.90544006
115EP300_21415370_ChIP-Seq_HL-1_Mouse0.90426337
116SMAD4_21741376_ChIP-Seq_HESCs_Human0.89986409
117FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.89255828
118ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89096676
119ERG_21242973_ChIP-ChIP_JURKAT_Human0.88477379
120SUZ12_18555785_Chip-Seq_ESCs_Mouse0.88380308
121GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88360815
122NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88044873
123EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.87454603
124HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87035769
125OCT4_18555785_Chip-Seq_ESCs_Mouse0.86961503
126CTCF_27219007_Chip-Seq_Bcells_Human0.86769390
127MYC_19915707_ChIP-ChIP_AK7_Human0.85858495
128OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85144717
129P53_22387025_ChIP-Seq_ESCs_Mouse0.83454687
130SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.83076092
131* RNF2_27304074_Chip-Seq_ESCs_Mouse0.83007640
132HNFA_21074721_ChIP-Seq_CACO-2_Human0.82609588
133RAD21_21589869_ChIP-Seq_MESCs_Mouse0.82266569
134GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.82008310
135BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.80165216
136RAC3_21632823_ChIP-Seq_H3396_Human0.79404174
137* CDX2_22108803_ChIP-Seq_LS180_Human0.78315365
138NANOG_18692474_ChIP-Seq_MEFs_Mouse0.77558710
139SMC4_20622854_ChIP-Seq_HELA_Human0.77339623
140MTF2_20144788_ChIP-Seq_MESCs_Mouse0.77313341
141WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.76953577
142TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.76423219
143P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.76297661
144TP63_23658742_ChIP-Seq_EP156T_Human0.75768142
145TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.75100724
146EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.74912329
147TAF2_19829295_ChIP-Seq_ESCs_Human0.73099062
148TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71404708
149ARNT_22903824_ChIP-Seq_MCF-7_Human0.71075231
150SOX2_18692474_ChIP-Seq_MEFs_Mouse0.70402247
151GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.70216107
152KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.70167387
153FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.70077696
154VDR_24787735_ChIP-Seq_THP-1_Human0.69101492
155GATA2_19941826_ChIP-Seq_K562_Human0.68494857
156SMAD4_21741376_ChIP-Seq_EPCs_Human0.67302450
157SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67055750
158P300_27058665_Chip-Seq_ZR-75-30cells_Human0.66376338
159TET1_21451524_ChIP-Seq_MESCs_Mouse0.65466661
160CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.65446229
161WT1_25993318_ChIP-Seq_PODOCYTE_Human0.65359442
162CREB1_26743006_Chip-Seq_LNCaP_Human0.64930276
163CEBPB_22108803_ChIP-Seq_LS180_Human0.64850385

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.66748627
2MP0004043_abnormal_pH_regulation6.53042554
3MP0004019_abnormal_vitamin_homeostasis5.09931119
4MP0005332_abnormal_amino_acid4.96517713
5MP0002139_abnormal_hepatobiliary_system4.84945596
6MP0003195_calcinosis4.10810546
7MP0002138_abnormal_hepatobiliary_system4.07653536
8MP0001765_abnormal_ion_homeostasis3.90105259
9* MP0009643_abnormal_urine_homeostasis3.81160010
10MP0005636_abnormal_mineral_homeostasis3.19232200
11MP0001756_abnormal_urination3.03197273
12MP0005377_hearing/vestibular/ear_phenot3.02248240
13MP0003878_abnormal_ear_physiology3.02248240
14MP0008875_abnormal_xenobiotic_pharmacok2.99780861
15* MP0002136_abnormal_kidney_physiology2.84056185
16MP0001958_emphysema2.77841873
17MP0003252_abnormal_bile_duct2.53171640
18MP0005365_abnormal_bile_salt2.29343848
19MP0005085_abnormal_gallbladder_physiolo2.22102863
20MP0005058_abnormal_lysosome_morphology2.19141742
21MP0003186_abnormal_redox_activity1.79872535
22MP0008961_abnormal_basal_metabolism1.73476694
23MP0004885_abnormal_endolymph1.72764919
24MP0005584_abnormal_enzyme/coenzyme_acti1.68090735
25MP0000538_abnormal_urinary_bladder1.62007230
26MP0001270_distended_abdomen1.57113330
27MP0000534_abnormal_ureter_morphology1.51387956
28MP0005084_abnormal_gallbladder_morpholo1.46689018
29MP0003300_gastrointestinal_ulcer1.39168241
30MP0005319_abnormal_enzyme/_coenzyme1.38147430
31MP0003806_abnormal_nucleotide_metabolis1.36779539
32MP0005451_abnormal_body_composition1.36463000
33MP0002928_abnormal_bile_duct1.34747570
34MP0002876_abnormal_thyroid_physiology1.27421439
35MP0002168_other_aberrant_phenotype1.26402591
36MP0006036_abnormal_mitochondrial_physio1.25678386
37MP0003011_delayed_dark_adaptation1.19999434
38MP0000230_abnormal_systemic_arterial1.18276988
39MP0004147_increased_porphyrin_level1.11287533
40MP0002135_abnormal_kidney_morphology1.08506852
41MP0005535_abnormal_body_temperature1.07104278
42MP0005670_abnormal_white_adipose1.06886385
43MP0002896_abnormal_bone_mineralization1.03399012
44MP0002089_abnormal_postnatal_growth/wei0.99549498
45MP0008872_abnormal_physiological_respon0.99204164
46MP0004130_abnormal_muscle_cell0.98798488
47MP0001764_abnormal_homeostasis0.96028042
48MP0003172_abnormal_lysosome_physiology0.95872973
49MP0005666_abnormal_adipose_tissue0.95728199
50MP0003283_abnormal_digestive_organ0.94424336
51MP0008004_abnormal_stomach_pH0.93980853
52MP0003045_fibrosis0.92651542
53MP0001666_abnormal_nutrient_absorption0.88421926
54MP0002118_abnormal_lipid_homeostasis0.87832449
55MP0004264_abnormal_extraembryonic_tissu0.86371886
56MP0003646_muscle_fatigue0.81345040
57MP0003638_abnormal_response/metabolism_0.80927037
58MP0003191_abnormal_cellular_cholesterol0.80338657
59MP0000747_muscle_weakness0.74856316
60MP0001661_extended_life_span0.74539500
61* MP0009642_abnormal_blood_homeostasis0.72294399
62MP0010234_abnormal_vibrissa_follicle0.71009794
63MP0005220_abnormal_exocrine_pancreas0.66610040
64MP0009764_decreased_sensitivity_to0.66539514
65MP0005083_abnormal_biliary_tract0.64583941
66MP0000371_diluted_coat_color0.63864355
67MP0005395_other_phenotype0.62887456
68MP0002796_impaired_skin_barrier0.62302284
69MP0001485_abnormal_pinna_reflex0.61593046
70MP0000609_abnormal_liver_physiology0.61513029
71MP0010329_abnormal_lipoprotein_level0.58908842
72MP0003879_abnormal_hair_cell0.56094506
73MP0003959_abnormal_lean_body0.56081500
74MP0002108_abnormal_muscle_morphology0.53933161
75MP0008469_abnormal_protein_level0.53808357
76MP0002115_abnormal_skeleton_extremities0.53067273
77MP0000598_abnormal_liver_morphology0.52073009
78MP0003329_amyloid_beta_deposits0.51536854
79MP0006035_abnormal_mitochondrial_morpho0.51527468
80MP0004742_abnormal_vestibular_system0.51444378
81MP0000678_abnormal_parathyroid_gland0.50927560
82MP0003938_abnormal_ear_development0.50817406
83MP0009115_abnormal_fat_cell0.50524455
84MP0005501_abnormal_skin_physiology0.50513225
85MP0005452_abnormal_adipose_tissue0.49390382
86MP0002998_abnormal_bone_remodeling0.48946756
87MP0002970_abnormal_white_adipose0.46829723
88MP0005408_hypopigmentation0.46549256
89MP0003795_abnormal_bone_structure0.46189614
90MP0009053_abnormal_anal_canal0.46063069
91MP0002078_abnormal_glucose_homeostasis0.46006197
92MP0003953_abnormal_hormone_level0.44956343
93MP0005334_abnormal_fat_pad0.44231921
94MP0000026_abnormal_inner_ear0.44205978
95MP0005165_increased_susceptibility_to0.43495418
96MP0002069_abnormal_eating/drinking_beha0.43006758
97MP0010386_abnormal_urinary_bladder0.42126157
98MP0005645_abnormal_hypothalamus_physiol0.41343148
99MP0003942_abnormal_urinary_system0.39802177
100MP0000163_abnormal_cartilage_morphology0.39219039
101MP0005375_adipose_tissue_phenotype0.39070804
102MP0004858_abnormal_nervous_system0.38856823
103MP0002132_abnormal_respiratory_system0.37736400
104MP0004484_altered_response_of0.37138955
105MP0001944_abnormal_pancreas_morphology0.37063883
106MP0001663_abnormal_digestive_system0.36667497
107MP0004272_abnormal_basement_membrane0.36248120
108MP0005379_endocrine/exocrine_gland_phen0.35815563
109MP0002638_abnormal_pupillary_reflex0.35260103
110MP0010368_abnormal_lymphatic_system0.34978825
111MP0005448_abnormal_energy_balance0.34534823
112MP0009672_abnormal_birth_weight0.34251888
113MP0001963_abnormal_hearing_physiology0.33812217
114MP0001191_abnormal_skin_condition0.33706146
115MP0002098_abnormal_vibrissa_morphology0.33444304
116MP0004215_abnormal_myocardial_fiber0.33405897
117MP0003221_abnormal_cardiomyocyte_apopto0.33159627
118MP0000566_synostosis0.32986349
119MP0000631_abnormal_neuroendocrine_gland0.32920919
120MP0001177_atelectasis0.32587795
121MP0006138_congestive_heart_failure0.32330712
122MP0005167_abnormal_blood-brain_barrier0.32261751
123MP0001731_abnormal_postnatal_growth0.30623638
124MP0009780_abnormal_chondrocyte_physiolo0.28202274
125MP0005647_abnormal_sex_gland0.27443804
126MP0000467_abnormal_esophagus_morphology0.26767675
127MP0002971_abnormal_brown_adipose0.26277951
128MP0009703_decreased_birth_body0.26165553
129MP0005275_abnormal_skin_tensile0.25008225
130MP0002113_abnormal_skeleton_development0.24984819
131MP0000003_abnormal_adipose_tissue0.24848583
132MP0000920_abnormal_myelination0.24365556
133MP0003724_increased_susceptibility_to0.24240178
134MP0001664_abnormal_digestion0.23805904
135MP0003303_peritoneal_inflammation0.23713186
136MP0005646_abnormal_pituitary_gland0.22075377

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)7.95912513
2Hypokalemic alkalosis (HP:0001949)7.33732421
3Metabolic alkalosis (HP:0200114)7.23462292
4Hypomagnesemia (HP:0002917)6.92609455
5Gout (HP:0001997)6.88951372
6Hyperactive renin-angiotensin system (HP:0000841)6.76024616
7Polyuria (HP:0000103)6.63251997
8Abnormality of chloride homeostasis (HP:0011422)6.23578960
9Abnormal urine output (HP:0012590)6.21876212
10Abnormality of renal excretion (HP:0011036)5.96915610
11Abnormality of magnesium homeostasis (HP:0004921)5.86244996
12Proximal tubulopathy (HP:0000114)5.62970316
13Abnormal drinking behavior (HP:0030082)5.37230078
14Polydipsia (HP:0001959)5.37230078
15Increased purine levels (HP:0004368)4.92398844
16Hyperuricemia (HP:0002149)4.92398844
17Tetany (HP:0001281)4.84748551
18Abnormality of renin-angiotensin system (HP:0000847)4.84163032
19Alkalosis (HP:0001948)4.79112826
20Renal salt wasting (HP:0000127)4.68157322
21Abnormality of glutamine family amino acid metabolism (HP:0010902)4.65441191
22Hyperaldosteronism (HP:0000859)4.62452262
23Hyperglycinuria (HP:0003108)4.56120957
24Generalized aminoaciduria (HP:0002909)4.22480773
25Hypercalciuria (HP:0002150)4.16023432
26Abnormality of serine family amino acid metabolism (HP:0010894)3.78312237
27Abnormality of glycine metabolism (HP:0010895)3.78312237
28Glycosuria (HP:0003076)3.77172160
29Abnormality of urine glucose concentration (HP:0011016)3.77172160
30Hypokalemia (HP:0002900)3.69619291
31Ketoacidosis (HP:0001993)3.66550595
32Renal tubular acidosis (HP:0001947)3.59814799
33* Abnormality of purine metabolism (HP:0004352)3.49574227
34Hyperphosphaturia (HP:0003109)3.37042984
35Delayed epiphyseal ossification (HP:0002663)3.26552019
36Ketosis (HP:0001946)3.22650076
37Large eyes (HP:0001090)3.19437797
38Abnormal urine phosphate concentration (HP:0012599)3.19091595
39Abnormality of potassium homeostasis (HP:0011042)3.12161963
40Nephrocalcinosis (HP:0000121)3.04724746
41Hydroxyprolinuria (HP:0003080)3.01288989
42Abnormality of proline metabolism (HP:0010907)3.01288989
43Generalized muscle weakness (HP:0003324)2.96260195
44Hypophosphatemia (HP:0002148)2.78207539
45Vascular calcification (HP:0004934)2.75051212
46Abnormality of fatty-acid metabolism (HP:0004359)2.74980215
47Abnormality of aspartate family amino acid metabolism (HP:0010899)2.69916946
48Hyperglycinemia (HP:0002154)2.66044974
49Rickets (HP:0002748)2.63364993
50* Abnormality of nucleobase metabolism (HP:0010932)2.62045695
51Metaphyseal cupping (HP:0003021)2.61820955
52Delayed CNS myelination (HP:0002188)2.60124139
53Vacuolated lymphocytes (HP:0001922)2.58478912
54Widely patent fontanelles and sutures (HP:0004492)2.51240952
55* Nephrolithiasis (HP:0000787)2.50033470
56Dehydration (HP:0001944)2.45614945
57Cardiovascular calcification (HP:0011915)2.45336494
58Hyperammonemia (HP:0001987)2.37081564
59Abnormality of renal resorption (HP:0011038)2.33427939
60Hyponatremia (HP:0002902)2.32984966
61Dicarboxylic aciduria (HP:0003215)2.32587695
62Abnormality of dicarboxylic acid metabolism (HP:0010995)2.32587695
63Enlarged kidneys (HP:0000105)2.31208619
64Abnormality of sodium homeostasis (HP:0010931)2.29061147
65Abnormal enzyme/coenzyme activity (HP:0012379)2.27984393
66Metabolic acidosis (HP:0001942)2.24561440
67Vomiting (HP:0002013)2.24459274
68Confusion (HP:0001289)2.23206997
69Renal tubular dysfunction (HP:0000124)2.22363302
70Abnormality of alkaline phosphatase activity (HP:0004379)2.21874031
71Thin bony cortex (HP:0002753)2.20381781
72Malnutrition (HP:0004395)2.10993080
73Adrenal overactivity (HP:0002717)2.10198092
74Abnormality of aromatic amino acid family metabolism (HP:0004338)2.07937723
75Bilateral sensorineural hearing impairment (HP:0008619)2.07151640
76Impaired platelet aggregation (HP:0003540)2.07018854
77Abnormal platelet function (HP:0011869)2.07018854
78Abnormal tarsal ossification (HP:0008369)2.05690709
79Methylmalonic aciduria (HP:0012120)2.02635802
80Tubulointerstitial fibrosis (HP:0005576)2.01232091
81Abnormality of sulfur amino acid metabolism (HP:0004339)2.00357043
82Lethargy (HP:0001254)1.99845818
83Potter facies (HP:0002009)1.95697353
84Facial shape deformation (HP:0011334)1.95697353
85Tubular atrophy (HP:0000092)1.95352933
86Chondrocalcinosis (HP:0000934)1.95132887
87Lymphangioma (HP:0100764)1.89929668
88Bicornuate uterus (HP:0000813)1.89913018
89Abnormality of the costochondral junction (HP:0000919)1.86546361
90Metaphyseal irregularity (HP:0003025)1.86134543
91Abnormality of Sharpey fibers (HP:0100685)1.82962454
92Elevated alkaline phosphatase (HP:0003155)1.79981932
93Sensorimotor neuropathy (HP:0007141)1.78778991
94Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.77308590
95Metaphyseal dysplasia (HP:0100255)1.77096530
96Decreased circulating renin level (HP:0003351)1.75178303
97Nausea (HP:0002018)1.75107700
98Irritability (HP:0000737)1.74323308
99Tachypnea (HP:0002789)1.69201274
100Glomerulosclerosis (HP:0000096)1.67444727
101Abnormality of serum amino acid levels (HP:0003112)1.67288301
102Hypotension (HP:0002615)1.65854479
103Abnormality of carpal bone ossification (HP:0006257)1.62745462
104Neonatal onset (HP:0003623)1.62032469
105Focal segmental glomerulosclerosis (HP:0000097)1.59272537
106Abnormality of the renal medulla (HP:0100957)1.35609905
107Premature birth (HP:0001622)1.33828646
108Nephrogenic diabetes insipidus (HP:0009806)1.32727427
109Osteopenia (HP:0000938)1.32187445
110Paresthesia (HP:0003401)1.28745072
111Abnormality of macular pigmentation (HP:0008002)1.22572373
112Hypophosphatemic rickets (HP:0004912)1.19595269
113Intellectual disability, moderate (HP:0002342)1.18296937
114Abnormality of the fingertips (HP:0001211)1.18081734
115Abnormal eating behavior (HP:0100738)1.15234713
116Tubulointerstitial abnormality (HP:0001969)1.14389903
117Hyperkalemia (HP:0002153)1.12512087
118Thyroid-stimulating hormone excess (HP:0002925)1.09360880
119Abnormality of calcium-phosphate metabolism (HP:0100530)1.06482670
120Hypothermia (HP:0002045)0.98797363
121Enlarged epiphyses (HP:0010580)0.97907566
122Polyhydramnios (HP:0001561)0.97161432
123Neonatal death (HP:0003811)0.91655673
124Osteomalacia (HP:0002749)0.90929818
125Chorioretinal atrophy (HP:0000533)0.87723813
126Small for gestational age (HP:0001518)0.86467983
127Stage 5 chronic kidney disease (HP:0003774)0.81608090
128Visceral angiomatosis (HP:0100761)0.77261691
129Esophageal varix (HP:0002040)0.74855282
130Abnormality of the vitamin B12 metabolism (HP:0004341)0.73579462
131Abnormality of the renal cortex (HP:0011035)0.71637410

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK49.36301232
2WNK37.89363813
3OXSR17.57200222
4STK394.70889271
5BCKDK2.94366278
6STK38L2.46279288
7WNK12.04463715
8PDK41.94846270
9PDK31.94846270
10NEK11.94269413
11SGK2231.81421605
12SGK4941.81421605
13STK381.35204530
14PDK21.32280816
15MST1R1.20156645
16MST41.07287939
17SGK20.98712436
18FGFR40.94425852
19SGK30.93827844
20LRRK20.92654776
21PINK10.90050593
22EPHB10.79682723
23GRK60.79668396
24ARAF0.75792379
25GSK3A0.73257757
26PIM20.66056590
27MAP3K70.63647419
28SGK10.60114455
29DYRK1B0.57586277
30SMG10.55316400
31PTK20.53290153
32TIE10.53074129
33MAP3K30.51424910
34TGFBR20.50104790
35ABL20.48031109
36PRKAA10.46710117
37PAK40.45177089
38PKN10.45039641
39INSRR0.44871501
40MAPK110.42313412
41PDPK10.41417192
42ERN10.38965209
43PTK60.37764323
44TEC0.36862596
45PAK30.35866899
46MAP3K100.35088070
47PRKAA20.34369213
48PRKCI0.33522857
49MET0.32801834
50PRKD20.31548207
51FER0.29969878
52PRKCZ0.29362491
53STK110.28642060
54PTK2B0.28398479
55TRIB30.28246793
56STK100.27795587
57PDK10.27742786
58DDR20.27543129
59CAMK10.26620363
60MAP3K140.25943353
61LMTK20.25779798
62LATS20.25348873
63NTRK20.24605228
64FRK0.24507050
65FLT30.24009690
66NTRK10.23731666
67EPHB20.23168316
68RPS6KA20.22973912
69KDR0.22577419
70ERBB40.22529570
71NME20.22445433
72KIT0.21865937
73PRKCD0.21492045
74PIK3CG0.19727850
75RIPK10.19456431
76MAPK150.19110734
77MAP3K20.19109232
78GRK50.18949544
79MYLK0.18901620
80PRKCH0.17710530
81IRAK20.17657922
82LATS10.17562836
83PRKACG0.17103922
84MINK10.16202829
85EPHA40.15567942
86PKN20.15565268
87ADRBK20.14905379
88GRK10.14208935
89PIM10.13504173
90AKT20.13155404
91NLK0.12844149
92RPS6KL10.12754792
93RPS6KC10.12754792
94ERBB20.12653280
95PRKCA0.12228532
96BMX0.12002309
97NTRK30.10972911
98RPS6KA60.10622763
99RAF10.10420570
100PRKACA0.10217602
101IRAK30.09962958
102BRAF0.09342814
103JAK20.09169911
104MAP2K40.09073738
105ADRBK10.08475739
106SIK20.07742045
107PAK20.07267636
108MAPK70.07226004
109PRKCG0.06983355
110PRKD10.06943739
111MAPK30.06850317
112SCYL20.06774281
113MAP2K30.06602114
114INSR0.06047381
115SIK10.06010248
116MAPK120.05774444
117PRKCB0.05562794
118CAMKK20.05470026
119TRPM70.05215497
120PRKCE0.04990590
121ROCK10.04677281
122IRAK10.04534582
123SRC0.03277863
124PIK3CA0.03250002
125TESK10.02672439
126PRKCQ0.02154923
127MAPK100.02084253
128RET0.01756162
129DMPK0.01749750
130PRKG20.01613277
131CSK0.01547342
132MTOR0.00713986
133CAMK1G0.00554674
134MAP2K10.00494663
135PRKG10.00407729
136MAPK40.00088501
137CSNK1A1-0.0340254
138PRKD3-0.0329955
139NME1-0.0319293
140PDGFRA-0.0305934
141DAPK2-0.0284635
142ABL1-0.0248033
143CSNK1G1-0.0215859
144PRKACB-0.0131414
145CAMK4-0.0102835
146PNCK-0.0053312
147IGF1R-0.0052449
148RPS6KA3-0.0047238

Predicted pathways (KEGG)

RankGene SetZ-score
1Butanoate metabolism_Homo sapiens_hsa006503.90797676
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.90370343
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.56567662
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.46375540
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.30841504
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.15636904
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.13832282
8Propanoate metabolism_Homo sapiens_hsa006403.10851957
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.92013506
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.49994939
11Peroxisome_Homo sapiens_hsa041462.49297873
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.49135882
13Pyruvate metabolism_Homo sapiens_hsa006202.49006764
14Fatty acid degradation_Homo sapiens_hsa000712.34979348
15Collecting duct acid secretion_Homo sapiens_hsa049662.27062301
16Tryptophan metabolism_Homo sapiens_hsa003802.18596332
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.06787628
18Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.06447900
19Vitamin digestion and absorption_Homo sapiens_hsa049772.03162794
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.00354977
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.99758177
22beta-Alanine metabolism_Homo sapiens_hsa004101.94158617
23Fatty acid biosynthesis_Homo sapiens_hsa000611.80856910
24Fatty acid metabolism_Homo sapiens_hsa012121.76473841
25Sulfur metabolism_Homo sapiens_hsa009201.69109341
26Carbon metabolism_Homo sapiens_hsa012001.64667611
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.63519997
28Bile secretion_Homo sapiens_hsa049761.61895719
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.61486923
30Glutathione metabolism_Homo sapiens_hsa004801.58713455
31Arginine and proline metabolism_Homo sapiens_hsa003301.46500816
32Other glycan degradation_Homo sapiens_hsa005111.38712673
33Lysine degradation_Homo sapiens_hsa003101.29852543
34Protein digestion and absorption_Homo sapiens_hsa049741.24542129
35Mineral absorption_Homo sapiens_hsa049781.22534094
36PPAR signaling pathway_Homo sapiens_hsa033201.18994665
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.16944006
38Starch and sucrose metabolism_Homo sapiens_hsa005001.13000290
39Arginine biosynthesis_Homo sapiens_hsa002201.12949339
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12486409
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11633277
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09025133
43Histidine metabolism_Homo sapiens_hsa003401.07665522
44Selenocompound metabolism_Homo sapiens_hsa004501.04872983
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.02653425
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00965041
47Phenylalanine metabolism_Homo sapiens_hsa003600.95943912
48Glycerolipid metabolism_Homo sapiens_hsa005610.93513854
49Nitrogen metabolism_Homo sapiens_hsa009100.93454879
50Biosynthesis of amino acids_Homo sapiens_hsa012300.93132438
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88111450
52Folate biosynthesis_Homo sapiens_hsa007900.87566870
53Fructose and mannose metabolism_Homo sapiens_hsa000510.80158510
54Endometrial cancer_Homo sapiens_hsa052130.75682722
55Melanoma_Homo sapiens_hsa052180.74661441
56Oxidative phosphorylation_Homo sapiens_hsa001900.69990088
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.68906031
58Renin-angiotensin system_Homo sapiens_hsa046140.67940382
59Fatty acid elongation_Homo sapiens_hsa000620.67229431
60Gap junction_Homo sapiens_hsa045400.67035786
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.65930314
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64348951
63Lysosome_Homo sapiens_hsa041420.63671123
64Complement and coagulation cascades_Homo sapiens_hsa046100.62046539
65Pentose phosphate pathway_Homo sapiens_hsa000300.61111136
66Non-small cell lung cancer_Homo sapiens_hsa052230.59508755
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.59178553
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.58040921
69Pancreatic cancer_Homo sapiens_hsa052120.55597656
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.54418303
71Thyroid hormone synthesis_Homo sapiens_hsa049180.54345520
72Metabolic pathways_Homo sapiens_hsa011000.52861345
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51134878
74Chemical carcinogenesis_Homo sapiens_hsa052040.50095737
75Hepatitis C_Homo sapiens_hsa051600.49873428
76Gastric acid secretion_Homo sapiens_hsa049710.48958788
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45865675
78FoxO signaling pathway_Homo sapiens_hsa040680.44264362
79Steroid biosynthesis_Homo sapiens_hsa001000.37428462
80Glioma_Homo sapiens_hsa052140.37218275
81Vitamin B6 metabolism_Homo sapiens_hsa007500.36961729
82Retinol metabolism_Homo sapiens_hsa008300.36267577
83Parkinsons disease_Homo sapiens_hsa050120.36005396
84Vibrio cholerae infection_Homo sapiens_hsa051100.34894740
85Renin secretion_Homo sapiens_hsa049240.32553836
86Focal adhesion_Homo sapiens_hsa045100.32414661
87Arachidonic acid metabolism_Homo sapiens_hsa005900.32409931
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32308081
89Synaptic vesicle cycle_Homo sapiens_hsa047210.31201887
90Salivary secretion_Homo sapiens_hsa049700.30233071
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29976233
92ABC transporters_Homo sapiens_hsa020100.29366877
93ECM-receptor interaction_Homo sapiens_hsa045120.28034838
94Tyrosine metabolism_Homo sapiens_hsa003500.24608092
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.24290113
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.23230846
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.22954314
98Choline metabolism in cancer_Homo sapiens_hsa052310.21652889
99HIF-1 signaling pathway_Homo sapiens_hsa040660.21447813
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21133903
101Fat digestion and absorption_Homo sapiens_hsa049750.21066158
102Sphingolipid metabolism_Homo sapiens_hsa006000.18093166
103Sulfur relay system_Homo sapiens_hsa041220.17796366
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.16012922
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.15452916
106Rap1 signaling pathway_Homo sapiens_hsa040150.12527964
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.12242113
108Cardiac muscle contraction_Homo sapiens_hsa042600.11635550
109Morphine addiction_Homo sapiens_hsa050320.11466468
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.11008415
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.10995894
112Prostate cancer_Homo sapiens_hsa052150.10847141
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.08095479
114Alzheimers disease_Homo sapiens_hsa050100.07545925
115Inositol phosphate metabolism_Homo sapiens_hsa005620.07532641
116Insulin resistance_Homo sapiens_hsa049310.07278228
117Rheumatoid arthritis_Homo sapiens_hsa053230.06974391
118Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.05640143
119Galactose metabolism_Homo sapiens_hsa000520.02609576
120AMPK signaling pathway_Homo sapiens_hsa041520.00288560
121Hedgehog signaling pathway_Homo sapiens_hsa04340-0.0867224
122One carbon pool by folate_Homo sapiens_hsa00670-0.0778790
123Bladder cancer_Homo sapiens_hsa05219-0.0674110
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0410474
125Glucagon signaling pathway_Homo sapiens_hsa04922-0.0378295
126Huntingtons disease_Homo sapiens_hsa05016-0.0338245
127alpha-Linolenic acid metabolism_Homo sapiens_hsa00592-0.0080512

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