SLC22A13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 4. The encoded protein is a transmembrane protein involved in the transport of small molecules. This protein can function to mediate urate uptake and is a high affinity nicotinate exchanger in the kidneys and the intestine. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of antigen processing and presentation of peptide antigen (GO:0002583)9.53401908
2polyketide metabolic process (GO:0030638)8.08864482
3doxorubicin metabolic process (GO:0044598)8.08864482
4daunorubicin metabolic process (GO:0044597)8.08864482
5CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)7.73314839
6T-helper cell differentiation (GO:0042093)7.73314839
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)7.48034758
8lysine catabolic process (GO:0006554)7.12810579
9lysine metabolic process (GO:0006553)7.12810579
10urate metabolic process (GO:0046415)6.91572695
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.91417317
12negative regulation of thymocyte apoptotic process (GO:0070244)6.83894479
13alpha-beta T cell activation involved in immune response (GO:0002287)6.76355117
14T cell differentiation involved in immune response (GO:0002292)6.76355117
15alpha-beta T cell differentiation involved in immune response (GO:0002293)6.76355117
16sleep (GO:0030431)6.54163224
17drug transmembrane transport (GO:0006855)6.41521249
18mucosal-associated lymphoid tissue development (GO:0048537)6.16986255
19Peyers patch development (GO:0048541)6.16986255
20cellular modified amino acid catabolic process (GO:0042219)6.08264819
21negative regulation of glycogen biosynthetic process (GO:0045719)5.98266399
22positive regulation of antigen processing and presentation (GO:0002579)5.80009086
23drug transport (GO:0015893)5.76293299
24lymph node development (GO:0048535)5.65443248
25antigen processing and presentation of endogenous antigen (GO:0019883)5.62963432
26cytidine deamination (GO:0009972)5.60198576
27cytidine metabolic process (GO:0046087)5.60198576
28cytidine catabolic process (GO:0006216)5.60198576
29regulation of response to osmotic stress (GO:0047484)5.57947689
30negative regulation of T cell apoptotic process (GO:0070233)5.48745192
31poly(A)+ mRNA export from nucleus (GO:0016973)5.42276387
32transepithelial transport (GO:0070633)5.41970828
33cysteine metabolic process (GO:0006534)5.39197474
34regulation of gamma-delta T cell differentiation (GO:0045586)5.37267363
35modified amino acid transport (GO:0072337)5.33517230
36negative regulation of skeletal muscle tissue development (GO:0048642)5.31812335
37phosphate ion transport (GO:0006817)5.30620353
38response to gravity (GO:0009629)5.25664530
39excretion (GO:0007588)5.22726077
40positive regulation of type I interferon-mediated signaling pathway (GO:0060340)5.18977710
41* organic cation transport (GO:0015695)5.08754074
42response to muramyl dipeptide (GO:0032495)5.07979064
43valine metabolic process (GO:0006573)5.04929620
44biotin metabolic process (GO:0006768)4.94388047
45regulation of germinal center formation (GO:0002634)4.92845043
46CD4-positive, alpha-beta T cell activation (GO:0035710)4.86189264
47hormone catabolic process (GO:0042447)4.86136825
48CD4-positive, alpha-beta T cell differentiation (GO:0043367)4.85520603
49germ cell migration (GO:0008354)4.79703172
50quaternary ammonium group transport (GO:0015697)4.79620275
51regulation of apoptotic process involved in morphogenesis (GO:1902337)4.78633606
52phosphate ion transmembrane transport (GO:0035435)4.75943262
53negative regulation of epidermis development (GO:0045683)4.75931540
54negative regulation of meiotic cell cycle (GO:0051447)4.71849770
55pyrimidine ribonucleoside catabolic process (GO:0046133)4.69512691
56somite rostral/caudal axis specification (GO:0032525)4.64934385
57negative regulation of glycogen metabolic process (GO:0070874)4.62253422
58negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.60502756
59negative regulation of cell killing (GO:0031342)4.60502756
60positive regulation of circadian rhythm (GO:0042753)4.59669373
61indole-containing compound catabolic process (GO:0042436)4.59193797
62indolalkylamine catabolic process (GO:0046218)4.59193797
63tryptophan catabolic process (GO:0006569)4.59193797
64regulation of antigen processing and presentation (GO:0002577)4.58657069
65L-ascorbic acid metabolic process (GO:0019852)4.57631117
66cellular response to sterol (GO:0036315)4.57378364
67maintenance of protein location in nucleus (GO:0051457)4.55119086
68vitamin D metabolic process (GO:0042359)4.50917792
69regulation of gamma-delta T cell activation (GO:0046643)4.49777517
70branched-chain amino acid metabolic process (GO:0009081)4.48000974
71regulation of mammary gland epithelial cell proliferation (GO:0033599)4.46305492
72regulation of memory T cell differentiation (GO:0043380)4.45620205
73aspartate family amino acid catabolic process (GO:0009068)4.45258280
74coenzyme catabolic process (GO:0009109)4.42426940
75response to mercury ion (GO:0046689)4.41463623
762-oxoglutarate metabolic process (GO:0006103)4.36061910
77sulfur amino acid catabolic process (GO:0000098)4.31606720
78kynurenine metabolic process (GO:0070189)4.28409515
79negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.26202397
80cytokine biosynthetic process (GO:0042089)4.24284697
81positive regulation of digestive system process (GO:0060456)4.20349447
82renal absorption (GO:0070293)4.18402396
83tryptophan metabolic process (GO:0006568)4.17675792
84negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.17325552
85regulation of thymocyte apoptotic process (GO:0070243)4.14890912
86glyoxylate metabolic process (GO:0046487)4.10251922
87mitotic cell cycle arrest (GO:0071850)4.06944564
88muscle organ morphogenesis (GO:0048644)4.06860716
89nonribosomal peptide biosynthetic process (GO:0019184)4.06803602
90branched-chain amino acid catabolic process (GO:0009083)4.06536062
91vitamin transmembrane transport (GO:0035461)3.99186874
92regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.97011933
93negative regulation of glucose transport (GO:0010829)3.93597474
94G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.92001514
95aromatic amino acid family catabolic process (GO:0009074)3.91943525
96metanephric tubule development (GO:0072170)3.91160974
97metanephric nephron tubule development (GO:0072234)3.91160974
98RNA destabilization (GO:0050779)3.88568462
99regulation of chronic inflammatory response (GO:0002676)3.86594887
100fructose metabolic process (GO:0006000)3.84128305
101positive regulation of T cell cytokine production (GO:0002726)3.83081892
102cytokine production involved in immune response (GO:0002367)3.82928793
103glycoside metabolic process (GO:0016137)3.81914374
104cofactor transport (GO:0051181)3.78813688
105negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.76371619
106glutathione biosynthetic process (GO:0006750)3.75450676
107serine family amino acid catabolic process (GO:0009071)3.74868300
108peptidyl-threonine dephosphorylation (GO:0035970)3.73901084
109alpha-beta T cell differentiation (GO:0046632)3.72449928
110sulfur compound transport (GO:0072348)3.71304815
111ER overload response (GO:0006983)3.71216781
112response to phenylpropanoid (GO:0080184)3.68329845
113negative regulation of cell cycle G2/M phase transition (GO:1902750)3.68308225
114inactivation of MAPK activity (GO:0000188)3.64214083
115regulation of glycogen (starch) synthase activity (GO:2000465)3.62122524
116dicarboxylic acid catabolic process (GO:0043649)3.61968906
117mast cell activation involved in immune response (GO:0002279)3.61782548
118mast cell degranulation (GO:0043303)3.61782548
119negative regulation of epidermal cell differentiation (GO:0045605)3.61099762
120protein localization to kinetochore (GO:0034501)3.56865704
121tricarboxylic acid metabolic process (GO:0072350)3.56858123
122homocysteine metabolic process (GO:0050667)3.55761047
123regulation of MHC class I biosynthetic process (GO:0045343)3.55397884
124short-chain fatty acid metabolic process (GO:0046459)3.55353836
125quinone metabolic process (GO:1901661)3.55081857
126fat-soluble vitamin metabolic process (GO:0006775)3.54456238
127ribonucleoprotein complex disassembly (GO:0032988)3.54349171
128amino acid transmembrane transport (GO:0003333)3.53132601
129metanephric nephron epithelium development (GO:0072243)3.52567209
130histone H4-K8 acetylation (GO:0043982)3.51316933
131histone H4-K5 acetylation (GO:0043981)3.51316933
132epoxygenase P450 pathway (GO:0019373)3.50905690
133serine family amino acid metabolic process (GO:0009069)3.50859426
134cytokine metabolic process (GO:0042107)3.50665414
135endoderm formation (GO:0001706)3.49108141
136rRNA transcription (GO:0009303)3.48846872
137cardiovascular system development (GO:0072358)3.47588602
138negative regulation of glucose import (GO:0046325)3.45871700
139regulation of nuclear cell cycle DNA replication (GO:0033262)3.45415546
140nucleoside transmembrane transport (GO:1901642)3.45315419
141vitamin transport (GO:0051180)3.44391010
142interferon-gamma production (GO:0032609)3.42971171
143production of molecular mediator of immune response (GO:0002440)3.39702883
144acetyl-CoA metabolic process (GO:0006084)3.37206990
145regulation of transcription involved in cell fate commitment (GO:0060850)3.36970156
146hypotonic response (GO:0006971)3.34509938
147negative regulation of telomerase activity (GO:0051974)3.34044029
148negative regulation of lymphocyte apoptotic process (GO:0070229)3.32195234
149drug metabolic process (GO:0017144)3.31522411
150alpha-beta T cell activation (GO:0046631)3.30181039
151regulation of T cell apoptotic process (GO:0070232)3.29136831
152regulation of telomere maintenance via telomerase (GO:0032210)3.28569950
153positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.28264742
154notochord development (GO:0030903)3.28130835
155regulation of hippo signaling (GO:0035330)3.25017449
156glutamate metabolic process (GO:0006536)3.24387528
157regulation of clathrin-mediated endocytosis (GO:2000369)3.23538367
158leukocyte aggregation (GO:0070486)3.23516523
159L-phenylalanine metabolic process (GO:0006558)3.22622116
160erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.22622116
161cellular amino acid catabolic process (GO:0009063)3.21038043
162positive regulation of heat generation (GO:0031652)3.20691927
163amino-acid betaine metabolic process (GO:0006577)3.19278962
164regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.18054176
165polyol transport (GO:0015791)3.17989472
166phenol-containing compound catabolic process (GO:0019336)3.16273450
167toxin transport (GO:1901998)3.15774032
168T cell activation involved in immune response (GO:0002286)3.15572496
169regulation of T cell mediated cytotoxicity (GO:0001914)3.15180043
170metanephric epithelium development (GO:0072207)3.15153157
171protein-cofactor linkage (GO:0018065)3.12408721
172positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.11309868
173positive regulation of T cell mediated cytotoxicity (GO:0001916)3.10673219
174regulation of regulatory T cell differentiation (GO:0045589)3.09652748
175negative regulation of lipid storage (GO:0010888)3.08694950
176negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.07876586
177negative regulation of T-helper cell differentiation (GO:0045623)3.07876586
178regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.03586946
179negative regulation of interleukin-1 beta production (GO:0032691)3.03280103
180very-low-density lipoprotein particle assembly (GO:0034379)3.03120216
181protein K11-linked deubiquitination (GO:0035871)3.03064190
182regulation of RNA export from nucleus (GO:0046831)3.02687388
183negative regulation of interleukin-1 production (GO:0032692)3.01338639
184regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.00371853
185negative regulation of leukocyte apoptotic process (GO:2000107)2.99636290
186negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.97430790
187response to sterol (GO:0036314)2.96445499
188negative regulation of innate immune response (GO:0045824)2.95648119
189positive regulation of osteoclast differentiation (GO:0045672)2.95570569
190tolerance induction (GO:0002507)2.89809527
191striated muscle atrophy (GO:0014891)2.87833559
192regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.83743672
193regulation of mitotic spindle checkpoint (GO:1903504)2.83743672
194meiotic chromosome segregation (GO:0045132)2.79956046
195dendritic cell chemotaxis (GO:0002407)2.79802299
196regulation of integrin activation (GO:0033623)2.78845754
197aminoglycoside antibiotic metabolic process (GO:0030647)11.2320309
198antigen processing and presentation via MHC class Ib (GO:0002475)10.5045172

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human9.27650460
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.73760031
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human6.65271834
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.03672890
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.03672890
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.03672890
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.95722627
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.46237837
9ZNF652_21678463_ChIP-ChIP_ZR75-1_Human3.43607622
10NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.26980410
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.06754175
12ESR1_15608294_ChIP-ChIP_MCF-7_Human2.87169262
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.83442779
14SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.78279910
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.76315924
16POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.70317323
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.67612978
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.63393920
19NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.60234441
20NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.59403392
21TCF3_18692474_ChIP-Seq_MEFs_Mouse2.54962021
22RUNX_20019798_ChIP-Seq_JUKART_Human2.51680528
23SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.40275332
24TCF3_18692474_ChIP-Seq_MESCs_Mouse2.38078915
25STAT3_1855785_ChIP-Seq_MESCs_Mouse2.26749636
26NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.25728694
27SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.16177990
28CDX2_20551321_ChIP-Seq_CACO-2_Human2.13409272
29TP63_19390658_ChIP-ChIP_HaCaT_Human2.08274389
30NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.05014314
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.94218363
32ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.92130669
33MYB_26560356_Chip-Seq_TH2_Human1.89295032
34IRF8_22096565_ChIP-ChIP_GC-B_Human1.86177466
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.84319315
36AR_21909140_ChIP-Seq_LNCAP_Human1.81908622
37NANOG_18692474_ChIP-Seq_MEFs_Mouse1.78051869
38KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.75960524
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.73804813
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.73152137
41HIF1A_21447827_ChIP-Seq_MCF-7_Human1.72478263
42ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.69331435
43EGR1_23403033_ChIP-Seq_LIVER_Mouse1.66507078
44TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.64328198
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.63288790
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.62447534
47NANOG_18692474_ChIP-Seq_MESCs_Mouse1.61862798
48RXR_22158963_ChIP-Seq_LIVER_Mouse1.60169970
49IRF1_19129219_ChIP-ChIP_H3396_Human1.59816605
50UTX_26944678_Chip-Seq_JUKART_Human1.58002571
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.57820113
52POU5F1_16518401_ChIP-PET_MESCs_Mouse1.57637962
53ESR1_21235772_ChIP-Seq_MCF-7_Human1.56970573
54ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.55674432
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.50063161
56POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.49532203
57FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.48713906
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.48205005
59PPARA_22158963_ChIP-Seq_LIVER_Mouse1.44433070
60SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.42226180
61OCT4_18692474_ChIP-Seq_MEFs_Mouse1.40483095
62EGR1_19374776_ChIP-ChIP_THP-1_Human1.39694251
63SOX2_18692474_ChIP-Seq_MEFs_Mouse1.39065696
64SOX2_18692474_ChIP-Seq_MESCs_Mouse1.36688917
65MAF_26560356_Chip-Seq_TH1_Human1.35820951
66BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.35635912
67SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35600479
68HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.33933061
69NANOG_16518401_ChIP-PET_MESCs_Mouse1.33728879
70ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.33446695
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33230252
72RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31436671
73E2F1_17053090_ChIP-ChIP_MCF-7_Human1.29894330
74GATA2_21666600_ChIP-Seq_HMVEC_Human1.27736228
75PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.26630259
76STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25505445
77CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.25336465
78STAT4_19710469_ChIP-ChIP_TH1__Mouse1.24234319
79FOXM1_23109430_ChIP-Seq_U2OS_Human1.23154024
80PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21730786
81SMC4_20622854_ChIP-Seq_HELA_Human1.21177247
82NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.19815903
83MYB_26560356_Chip-Seq_TH1_Human1.18416492
84RACK7_27058665_Chip-Seq_MCF-7_Human1.18111051
85FOXO3_23340844_ChIP-Seq_DLD1_Human1.15595411
86ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15036578
87STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.14188216
88GATA3_27048872_Chip-Seq_THYMUS_Human1.12848505
89VDR_22108803_ChIP-Seq_LS180_Human1.12259583
90LXR_22158963_ChIP-Seq_LIVER_Mouse1.11875562
91DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11801092
92GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11719183
93MAF_26560356_Chip-Seq_TH2_Human1.10286867
94LXR_22292898_ChIP-Seq_THP-1_Human1.10111967
95SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10008444
96ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07969761
97TP53_22127205_ChIP-Seq_IMR90_Human1.06275505
98IRF8_27001747_Chip-Seq_BMDM_Mouse1.05805576
99NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04630869
100TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03035126
101SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.02834144
102IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02353108
103YY1_21170310_ChIP-Seq_MESCs_Mouse1.01371437
104TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01266163
105CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01048064
106E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01006969
107* GATA3_21878914_ChIP-Seq_MCF-7_Human1.00138143
108GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99935276
109NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99912589
110ELK4_26923725_Chip-Seq_MESODERM_Mouse0.98899894
111TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98777279
112NANOG_16153702_ChIP-ChIP_HESCs_Human0.98241680
113CLOCK_20551151_ChIP-Seq_293T_Human0.96212121
114SMAD_19615063_ChIP-ChIP_OVARY_Human0.96107154
115VDR_24787735_ChIP-Seq_THP-1_Human0.96097500
116JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95295646
117BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.95108797
118SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93179482
119SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92754601
120MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.92640635
121GATA6_25053715_ChIP-Seq_YYC3_Human0.92083557
122* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91200940
123GATA3_26560356_Chip-Seq_TH2_Human0.91041320
124EOMES_21245162_ChIP-Seq_HESCs_Human0.90902614
125YY1_22570637_ChIP-Seq_MALME-3M_Human0.90410689
126EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90229838
127NCOR1_26117541_ChIP-Seq_K562_Human0.89128375
128PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88906149
129Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.87873245
130STAT6_21828071_ChIP-Seq_BEAS2B_Human0.87583710
131NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87115286
132RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86709228
133NANOG_21062744_ChIP-ChIP_HESCs_Human0.86699729
134WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.86223852
135E2F4_17652178_ChIP-ChIP_JURKAT_Human0.85995622
136P68_20966046_ChIP-Seq_HELA_Human0.84570941
137JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84072553
138PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83934553
139CTCF_21964334_Chip-Seq_Bcells_Human0.83141200
140CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.82893157
141HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82880423
142TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.82687043
143* CJUN_26792858_Chip-Seq_BT549_Human0.82545661
144GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.82400682
145PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.82149173
146ESET_19884257_ChIP-Seq_ESCs_Mouse0.81930741
147CSB_26484114_Chip-Seq_FIBROBLAST_Human0.81825694
148RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.81730280
149CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81615620
150TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.81351329
151GATA2_22383799_ChIP-Seq_G1ME_Mouse0.81065718
152EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.80987182
153ERG_21242973_ChIP-ChIP_JURKAT_Human0.80234937
154GATA4_25053715_ChIP-Seq_YYC3_Human0.80119319
155KDM2B_26808549_Chip-Seq_SUP-B15_Human0.80006948
156CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78969525
157EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.78448499
158E2F7_22180533_ChIP-Seq_HELA_Human0.78419365
159PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77723821
160CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.77599643
161TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77505938
162BCOR_27268052_Chip-Seq_Bcells_Human0.77447939
163CREB1_15753290_ChIP-ChIP_HEK293T_Human0.77097004
164CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.77037249
165TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.76948375
166POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.76846452
167ELK3_25401928_ChIP-Seq_HUVEC_Human0.76351097
168BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.76331373
169VDR_24763502_ChIP-Seq_THP-1_Human0.75329875
170P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.74793416
171MYC_22102868_ChIP-Seq_BL_Human0.74316053
172ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.74112589
173PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74102129
174MYC_19079543_ChIP-ChIP_MESCs_Mouse0.74042178
175POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.73057532
176TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.72277102
177SMC3_22415368_ChIP-Seq_MEFs_Mouse0.70870908
178SMRT_27268052_Chip-Seq_Bcells_Human0.70533792
179TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.70391189
180BRD4_27068464_Chip-Seq_AML-cells_Mouse0.70384760
181RAC3_21632823_ChIP-Seq_H3396_Human0.69593177
182GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.68828488
183SUZ12_27294783_Chip-Seq_NPCs_Mouse0.68571856
184BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.68529589
185AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.68360081

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to6.58261452
2MP0004043_abnormal_pH_regulation6.16958891
3MP0005360_urolithiasis6.04296197
4MP0004147_increased_porphyrin_level4.76803762
5MP0005671_abnormal_response_to4.54273871
6MP0004264_abnormal_extraembryonic_tissu4.03174709
7MP0005332_abnormal_amino_acid3.75824321
8MP0003436_decreased_susceptibility_to3.61094034
9MP0004019_abnormal_vitamin_homeostasis3.60521585
10MP0003011_delayed_dark_adaptation3.13024582
11MP0003763_abnormal_thymus_physiology3.02262499
12MP0003656_abnormal_erythrocyte_physiolo3.01783616
13MP0003195_calcinosis2.96021061
14MP0009643_abnormal_urine_homeostasis2.89240618
15MP0004947_skin_inflammation2.87976968
16MP0008961_abnormal_basal_metabolism2.87581465
17MP0002933_joint_inflammation2.85086485
18MP0002254_reproductive_system_inflammat2.80909032
19MP0004858_abnormal_nervous_system2.77928133
20MP0009785_altered_susceptibility_to2.60010476
21MP0001765_abnormal_ion_homeostasis2.55824941
22MP0000569_abnormal_digit_pigmentation2.55366077
23MP0001835_abnormal_antigen_presentation2.52559792
24MP0001756_abnormal_urination2.51509312
25MP0010386_abnormal_urinary_bladder2.50996742
26MP0006292_abnormal_olfactory_placode2.40452579
27MP0002139_abnormal_hepatobiliary_system2.40132146
28MP0003890_abnormal_embryonic-extraembry2.33854913
29MP0005394_taste/olfaction_phenotype2.26795000
30MP0005499_abnormal_olfactory_system2.26795000
31MP0002009_preneoplasia2.25658946
32MP0001501_abnormal_sleep_pattern2.23377338
33MP0006035_abnormal_mitochondrial_morpho2.23039606
34MP0005377_hearing/vestibular/ear_phenot2.21276730
35MP0003878_abnormal_ear_physiology2.21276730
36MP0005000_abnormal_immune_tolerance2.20976734
37MP0008875_abnormal_xenobiotic_pharmacok2.15563856
38MP0002136_abnormal_kidney_physiology2.10718961
39MP0005174_abnormal_tail_pigmentation2.09241837
40MP0003828_pulmonary_edema2.08237732
41MP0005636_abnormal_mineral_homeostasis2.03974825
42MP0002332_abnormal_exercise_endurance1.99130267
43MP0002166_altered_tumor_susceptibility1.97559465
44MP0001533_abnormal_skeleton_physiology1.96728873
45MP0002138_abnormal_hepatobiliary_system1.83524707
46MP0001188_hyperpigmentation1.83485099
47MP0003122_maternal_imprinting1.78347148
48MP0005257_abnormal_intraocular_pressure1.75319585
49MP0005075_abnormal_melanosome_morpholog1.74716351
50MP0002723_abnormal_immune_serum1.64583326
51MP0005025_abnormal_response_to1.62268375
52MP0002148_abnormal_hypersensitivity_rea1.61887220
53MP0003283_abnormal_digestive_organ1.61399129
54MP0002877_abnormal_melanocyte_morpholog1.61358265
55MP0003705_abnormal_hypodermis_morpholog1.60712001
56MP0001243_abnormal_dermal_layer1.57125804
57MP0002419_abnormal_innate_immunity1.56145026
58MP0010234_abnormal_vibrissa_follicle1.55874583
59MP0000678_abnormal_parathyroid_gland1.54695200
60MP0000685_abnormal_immune_system1.53961146
61MP0001851_eye_inflammation1.52324567
62MP0001984_abnormal_olfaction1.50600740
63MP0003943_abnormal_hepatobiliary_system1.49982929
64MP0001986_abnormal_taste_sensitivity1.49117948
65MP0003787_abnormal_imprinting1.48948475
66MP0004130_abnormal_muscle_cell1.48742479
67MP0003938_abnormal_ear_development1.46906615
68MP0002006_tumorigenesis1.45887276
69MP0005365_abnormal_bile_salt1.45346343
70MP0001800_abnormal_humoral_immune1.44034718
71MP0004957_abnormal_blastocyst_morpholog1.41998757
72MP0003315_abnormal_perineum_morphology1.40904592
73MP0005319_abnormal_enzyme/_coenzyme1.39243320
74MP0001293_anophthalmia1.37345111
75MP0003252_abnormal_bile_duct1.34866636
76MP0003186_abnormal_redox_activity1.32852781
77MP0006036_abnormal_mitochondrial_physio1.32235485
78MP0000467_abnormal_esophagus_morphology1.30596158
79MP0002452_abnormal_antigen_presenting1.29217694
80MP0002653_abnormal_ependyma_morphology1.25063427
81MP0003183_abnormal_peptide_metabolism1.24741957
82MP0005076_abnormal_cell_differentiation1.22575364
83MP0001853_heart_inflammation1.21681475
84MP0001819_abnormal_immune_cell1.19146094
85MP0006082_CNS_inflammation1.18529942
86MP0010329_abnormal_lipoprotein_level1.18132653
87MP0001879_abnormal_lymphatic_vessel1.15221430
88MP0000762_abnormal_tongue_morphology1.14270372
89MP0002420_abnormal_adaptive_immunity1.11507969
90MP0002722_abnormal_immune_system1.09820792
91MP0010155_abnormal_intestine_physiology1.08435512
92MP0001958_emphysema1.08087694
93MP0002092_abnormal_eye_morphology1.07558511
94MP0001849_ear_inflammation1.07462199
95MP0002088_abnormal_embryonic_growth/wei1.06253724
96MP0008877_abnormal_DNA_methylation1.06009259
97MP0005380_embryogenesis_phenotype1.05810881
98MP0001672_abnormal_embryogenesis/_devel1.05810881
99MP0003121_genomic_imprinting1.05007676
100MP0003984_embryonic_growth_retardation1.04668973
101MP0000703_abnormal_thymus_morphology1.04504207
102MP0002938_white_spotting1.04173158
103MP0000462_abnormal_digestive_system1.03843225
104MP0008057_abnormal_DNA_replication1.03229492
105MP0005085_abnormal_gallbladder_physiolo1.00660278
106MP0005584_abnormal_enzyme/coenzyme_acti0.97068126
107MP0002932_abnormal_joint_morphology0.96958976
108MP0002876_abnormal_thyroid_physiology0.94898121
109MP0009278_abnormal_bone_marrow0.94804029
110MP0004885_abnormal_endolymph0.94302502
111MP0000858_altered_metastatic_potential0.93626736
112MP0001919_abnormal_reproductive_system0.93323396
113MP0003191_abnormal_cellular_cholesterol0.93010145
114MP0009840_abnormal_foam_cell0.90994687
115MP0008260_abnormal_autophagy0.89768290
116MP0005084_abnormal_gallbladder_morpholo0.89514512
117MP0010352_gastrointestinal_tract_polyps0.88728947
118MP0000689_abnormal_spleen_morphology0.88204210
119MP0010030_abnormal_orbit_morphology0.88073918
120MP0005266_abnormal_metabolism0.87786901
121MP0005390_skeleton_phenotype0.87529028
122MP0004484_altered_response_of0.87480409
123MP0000647_abnormal_sebaceous_gland0.86762067
124MP0001845_abnormal_inflammatory_respons0.84883577
125MP0001440_abnormal_grooming_behavior0.83624594
126MP0003806_abnormal_nucleotide_metabolis0.82628246
127MP0002277_abnormal_respiratory_mucosa0.82429716
128MP0005083_abnormal_biliary_tract0.82376940
129MP0002098_abnormal_vibrissa_morphology0.79991746
130MP0005397_hematopoietic_system_phenotyp0.79391522
131MP0001545_abnormal_hematopoietic_system0.79391522
132MP0002135_abnormal_kidney_morphology0.77748010
133MP0002398_abnormal_bone_marrow0.77462415
134MP0002405_respiratory_system_inflammati0.77095162
135MP0002127_abnormal_cardiovascular_syste0.76824549
136MP0002796_impaired_skin_barrier0.75951992
137MP0003879_abnormal_hair_cell0.75908502
138MP0001790_abnormal_immune_system0.74999840
139MP0005387_immune_system_phenotype0.74999840
140MP0000343_altered_response_to0.73369664
141MP0009931_abnormal_skin_appearance0.73058115
142MP0009763_increased_sensitivity_to0.72873218
143MP0004185_abnormal_adipocyte_glucose0.71845999
144MP0000716_abnormal_immune_system0.71470644
145MP0008469_abnormal_protein_level0.70489592
146MP0001216_abnormal_epidermal_layer0.70026497
147MP0002095_abnormal_skin_pigmentation0.69988232
148MP0003123_paternal_imprinting0.69918205
149MP0002114_abnormal_axial_skeleton0.68472032
150MP0005670_abnormal_white_adipose0.68466481
151MP0005253_abnormal_eye_physiology0.68315838
152MP0000432_abnormal_head_morphology0.67449648
153MP0002086_abnormal_extraembryonic_tissu0.67087855
154MP0002928_abnormal_bile_duct0.66314421
155MP0008569_lethality_at_weaning0.66055536
156MP0000750_abnormal_muscle_regeneration0.65594617
157MP0009764_decreased_sensitivity_to0.64523895
158MP0002429_abnormal_blood_cell0.64450495
159MP0002396_abnormal_hematopoietic_system0.63661750
160MP0002970_abnormal_white_adipose0.62309575
161MP0002085_abnormal_embryonic_tissue0.62084006
162MP0002233_abnormal_nose_morphology0.60347830
163MP0000609_abnormal_liver_physiology0.58911953
164MP0000538_abnormal_urinary_bladder0.57171020
165MP0002084_abnormal_developmental_patter0.56265284
166MP0001270_distended_abdomen0.55974954
167MP0002269_muscular_atrophy0.55443984
168MP0008789_abnormal_olfactory_epithelium0.55349861
169MP0004272_abnormal_basement_membrane0.54731700
170MP0005451_abnormal_body_composition0.53771188
171MP0000230_abnormal_systemic_arterial0.51867528
172MP0000049_abnormal_middle_ear0.51130750
173MP0002168_other_aberrant_phenotype0.50903242
174MP0000358_abnormal_cell_content/0.49880199
175MP0000163_abnormal_cartilage_morphology0.49765193
176MP0000377_abnormal_hair_follicle0.49110739
177MP0001661_extended_life_span0.49039803
178MP0003137_abnormal_impulse_conducting0.48378254
179MP0000428_abnormal_craniofacial_morphol0.47976371
180MP0005376_homeostasis/metabolism_phenot0.47580937
181MP0009703_decreased_birth_body0.47406339
182MP0000534_abnormal_ureter_morphology0.46770889

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)8.15095423
2Stomach cancer (HP:0012126)7.68852859
3Abnormality of cells of the erythroid lineage (HP:0012130)6.92253605
4Gout (HP:0001997)6.70863095
5Prostate neoplasm (HP:0100787)6.45319768
6Hyperactive renin-angiotensin system (HP:0000841)6.22342682
7Increased circulating renin level (HP:0000848)6.07610027
8Hypomagnesemia (HP:0002917)6.04405614
9Metabolic alkalosis (HP:0200114)5.91360457
10Hypokalemic alkalosis (HP:0001949)5.66699844
11Prolonged neonatal jaundice (HP:0006579)5.65238886
12Abnormality of chloride homeostasis (HP:0011422)5.23950510
13Hyperglycinuria (HP:0003108)5.23532587
14Polyuria (HP:0000103)5.19762772
15Abnormality of magnesium homeostasis (HP:0004921)4.99582061
16Abnormal urine output (HP:0012590)4.95753223
17Hyperuricemia (HP:0002149)4.89214814
18Increased purine levels (HP:0004368)4.89214814
19Bilateral microphthalmos (HP:0007633)4.74172302
20Renal salt wasting (HP:0000127)4.68459242
21Hyperaldosteronism (HP:0000859)4.55050126
22Abnormality of chromosome segregation (HP:0002916)4.53815728
23Abnormality of renal excretion (HP:0011036)4.49107395
24Neoplasm of the peripheral nervous system (HP:0100007)4.36119540
25Hepatoblastoma (HP:0002884)4.35509500
26Proximal tubulopathy (HP:0000114)4.22624504
27Neuroendocrine neoplasm (HP:0100634)4.19482391
28Tetany (HP:0001281)4.17504763
29Polydipsia (HP:0001959)4.10609442
30Abnormal drinking behavior (HP:0030082)4.10609442
31Multiple enchondromatosis (HP:0005701)4.07204557
32Abnormality of glycine metabolism (HP:0010895)4.04629383
33Abnormality of serine family amino acid metabolism (HP:0010894)4.04629383
34Anhidrosis (HP:0000970)3.97823112
35Abnormality of renin-angiotensin system (HP:0000847)3.77981250
36Broad face (HP:0000283)3.72595643
37Spondylolisthesis (HP:0003302)3.68405093
38Growth hormone excess (HP:0000845)3.65434782
39Poikilocytosis (HP:0004447)3.60999905
40Abnormality of purine metabolism (HP:0004352)3.58398107
41Optic neuritis (HP:0100653)3.53253360
42Retrobulbar optic neuritis (HP:0100654)3.53253360
43Abnormality of glutamine family amino acid metabolism (HP:0010902)3.50100369
44Hypochromic microcytic anemia (HP:0004840)3.49374799
45Ketoacidosis (HP:0001993)3.48189933
46Conical tooth (HP:0000698)3.45048982
47Alkalosis (HP:0001948)3.40395559
48Hypercalciuria (HP:0002150)3.24865332
49Rimmed vacuoles (HP:0003805)3.20191380
50Reticulocytosis (HP:0001923)3.16040589
51Orchitis (HP:0100796)3.13363171
52Vacuolated lymphocytes (HP:0001922)3.07107854
53Type 2 muscle fiber atrophy (HP:0003554)3.05314983
54Malnutrition (HP:0004395)3.04504134
55Absent rod-and cone-mediated responses on ERG (HP:0007688)2.97961867
56Large hands (HP:0001176)2.97244061
57Renal tubular acidosis (HP:0001947)2.92690485
58Thyroid-stimulating hormone excess (HP:0002925)2.91766934
59Abnormality of the lower motor neuron (HP:0002366)2.88796652
60Hypokalemia (HP:0002900)2.83543439
61IgG deficiency (HP:0004315)2.82974114
62Hypoplasia of the uterus (HP:0000013)2.82894304
63Hypertensive crisis (HP:0100735)2.82012470
64Abnormality of the prostate (HP:0008775)2.81241777
65Rhabdomyosarcoma (HP:0002859)2.79548515
66Neoplasm of striated muscle (HP:0009728)2.76719440
67Abnormal cartilage morphology (HP:0002763)2.75382518
68Tinnitus (HP:0000360)2.74555955
69Fatigable weakness (HP:0003473)2.70396613
70Abnormality of the neuromuscular junction (HP:0003398)2.70396613
71Rib fusion (HP:0000902)2.68748278
72Agitation (HP:0000713)2.67872081
73Hyperventilation (HP:0002883)2.65454196
74Severe combined immunodeficiency (HP:0004430)2.62926701
75Ketosis (HP:0001946)2.60984191
76Hoarse voice (HP:0001609)2.56685789
77Aplasia/Hypoplasia of the tibia (HP:0005772)2.56539751
78Stomatitis (HP:0010280)2.55290385
79Short tibia (HP:0005736)2.52125222
80Hyponatremia (HP:0002902)2.47959460
81Abnormality of sodium homeostasis (HP:0010931)2.47089174
82Muscle fiber atrophy (HP:0100295)2.46945491
83Hyperglycinemia (HP:0002154)2.46290000
84Duplicated collecting system (HP:0000081)2.46186379
85Abnormality of nucleobase metabolism (HP:0010932)2.45015084
86Keratoconjunctivitis sicca (HP:0001097)2.44224695
87Abnormality of eosinophils (HP:0001879)2.43424547
88Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.42967740
89Delayed CNS myelination (HP:0002188)2.42872739
90Osteolytic defects of the hand bones (HP:0009699)2.40604871
91Osteolytic defects of the phalanges of the hand (HP:0009771)2.40604871
92Ragged-red muscle fibers (HP:0003200)2.40411889
93Myositis (HP:0100614)2.40005172
94Renal cortical cysts (HP:0000803)2.39298450
95Abnormality of the frontal sinuses (HP:0002687)2.38842809
96Abnormality of male internal genitalia (HP:0000022)2.38698359
97Abnormality of potassium homeostasis (HP:0011042)2.33830240
98Ependymoma (HP:0002888)2.33414639
99Nephrocalcinosis (HP:0000121)2.31691396
100Increased connective tissue (HP:0009025)2.29376922
101Delayed epiphyseal ossification (HP:0002663)2.26280071
102Abnormality of reticulocytes (HP:0004312)2.25000200
103Testicular atrophy (HP:0000029)2.23994607
104Abnormality of aspartate family amino acid metabolism (HP:0010899)2.19582456
105Tubular atrophy (HP:0000092)2.19434368
106Hyperinsulinemic hypoglycemia (HP:0000825)2.17818264
107Dehydration (HP:0001944)2.17687439
108White forelock (HP:0002211)2.17287855
109Abnormality of the renal cortex (HP:0011035)2.16307468
110Pelvic girdle muscle weakness (HP:0003749)2.15805990
111Hand muscle atrophy (HP:0009130)2.14336088
112Keratoconjunctivitis (HP:0001096)2.13254177
113Abnormality of fatty-acid metabolism (HP:0004359)2.12974560
114Metabolic acidosis (HP:0001942)2.11993827
115Combined immunodeficiency (HP:0005387)2.10920971
116Vomiting (HP:0002013)2.07066670
117Abnormality of the renal collecting system (HP:0004742)2.05276230
118Nephrolithiasis (HP:0000787)2.03534793
119Shawl scrotum (HP:0000049)2.03283740
120Partial duplication of thumb phalanx (HP:0009944)2.02237491
121Generalized aminoaciduria (HP:0002909)2.02223798
122Metaphyseal cupping (HP:0003021)2.01517648
123Hyperphosphaturia (HP:0003109)2.00603237
124Widely patent fontanelles and sutures (HP:0004492)2.00565298
125Aplasia/hypoplasia of the uterus (HP:0008684)1.99701008
126Vaginal fistula (HP:0004320)1.99549988
127Dicarboxylic aciduria (HP:0003215)1.99405737
128Abnormality of dicarboxylic acid metabolism (HP:0010995)1.99405737
129Rectal fistula (HP:0100590)1.99272181
130Rectovaginal fistula (HP:0000143)1.99272181
131Abnormality of the endocardium (HP:0004306)1.98837271
132Xerostomia (HP:0000217)1.98559569
133Short humerus (HP:0005792)1.98152595
134Chondrocalcinosis (HP:0000934)1.97998988
135Pulmonary infiltrates (HP:0002113)1.97487503
136Hyperpituitarism (HP:0010514)1.96918760
137Aplasia/hypoplasia of the humerus (HP:0006507)1.96448595
138Rickets (HP:0002748)1.96394235
139Abnormality of dental color (HP:0011073)1.94785081
140Abnormality of the vocal cords (HP:0008777)1.94281420
141Lymphangioma (HP:0100764)1.94135592
142Hyperammonemia (HP:0001987)1.92794158
143Onycholysis (HP:0001806)1.92083311
144Pili torti (HP:0003777)1.91993235
145Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.90494728
146Decreased central vision (HP:0007663)1.90287092
147Increased serum pyruvate (HP:0003542)1.88622303
148Abnormality of glycolysis (HP:0004366)1.88622303
149Hypophosphatemia (HP:0002148)1.87857052
150Adrenal overactivity (HP:0002717)1.87599776
151Enlarged kidneys (HP:0000105)1.87303301
152Abnormality of sulfur amino acid metabolism (HP:0004339)1.87224212
153Abnormal rod and cone electroretinograms (HP:0008323)1.87061766
154Glycosuria (HP:0003076)1.86541513
155Abnormality of urine glucose concentration (HP:0011016)1.86541513
156Abnormality of Sharpey fibers (HP:0100685)1.86344064
157Abnormality of the hip-girdle musculature (HP:0001445)1.85775791
158Abnormality of the musculature of the pelvis (HP:0001469)1.85775791
159Neoplasm of the heart (HP:0100544)1.85628993
160Wide cranial sutures (HP:0010537)1.85266324
161Shoulder girdle muscle weakness (HP:0003547)1.83590087
162Bifid tongue (HP:0010297)1.83546591
163Abnormal urine phosphate concentration (HP:0012599)1.83091649
164Abnormality of the distal phalanges of the toes (HP:0010182)1.82003474
165Nephroblastoma (Wilms tumor) (HP:0002667)1.80632780
166Flat capital femoral epiphysis (HP:0003370)1.80252623
167Spastic tetraparesis (HP:0001285)1.77530082
168Irritability (HP:0000737)1.75854105
169T lymphocytopenia (HP:0005403)1.75486290
170Abnormal enzyme/coenzyme activity (HP:0012379)1.75159347
171Type II lissencephaly (HP:0007260)1.74916427
172Mitral stenosis (HP:0001718)1.74107321
173Abnormality of alkaline phosphatase activity (HP:0004379)1.73524729
174Abnormality of the salivary glands (HP:0010286)1.73290949
175Thyroiditis (HP:0100646)1.72551220
176Hypoplasia of the fovea (HP:0007750)1.71678602
177Aplasia/Hypoplasia of the fovea (HP:0008060)1.71678602
178Camptodactyly of toe (HP:0001836)1.71152123
179Hypotension (HP:0002615)1.70899565
180Prominent nose (HP:0000448)1.70875059
181Resting tremor (HP:0002322)1.70423155
182Partial duplication of the phalanx of hand (HP:0009999)1.70344162
183Neoplasm of head and neck (HP:0012288)1.70040516
184Esophageal neoplasm (HP:0100751)1.70040516
185Anomalous pulmonary venous return (HP:0010772)1.69028480
186Congenital sensorineural hearing impairment (HP:0008527)1.68805723
187Easy fatigability (HP:0003388)1.67989786

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK36.60566131
2CDK126.28340012
3OXSR14.52631192
4GRK54.49092611
5GRK64.15159082
6WNK44.04762911
7MAP2K23.87492183
8ERN13.79217006
9MAPKAPK33.38639532
10MAP3K143.04598785
11GRK12.79539387
12ADRBK22.64833156
13VRK22.62910848
14WNK12.62842075
15BRD42.40282212
16BUB12.38493736
17TGFBR22.33739526
18CSF1R2.14756014
19KSR22.10678918
20TESK210.9341421
21TTK1.97413736
22CCNB11.93983603
23IKBKE1.91932885
24IKBKB1.88380718
25TYRO31.84803883
26STK101.80749934
27GRK71.75789035
28MATK1.73969720
29RAF11.73735552
30MAPK71.69316579
31MARK31.62178451
32TBK11.59197776
33KSR11.56984658
34BMPR21.50629727
35STK391.50294287
36CAMKK21.46489616
37KIT1.44312550
38STK38L1.43225966
39MOS1.42036896
40NTRK11.40697328
41MAP2K11.39061796
42BCKDK1.38391011
43RPS6KA21.36227634
44PAK61.30002197
45TAOK31.27598099
46PDK31.27166450
47PDK41.27166450
48NEK11.26072650
49JAK11.21463309
50ARAF1.17920812
51CAMK41.17599348
52ZAK1.12387186
53MAP3K131.11992165
54PAK41.11947399
55MAP4K11.10646112
56PRKG21.09493682
57DAPK11.03540742
58PDK21.03501153
59PRKCH1.02752832
60STK380.98070756
61MAP2K40.96109633
62MAP3K120.95554340
63FRK0.90139535
64CHUK0.88866313
65EPHA20.87963343
66ADRBK10.87088854
67MARK20.86514977
68MAP3K70.85684135
69TLK10.85125438
70CDK70.84472901
71IRAK30.78324413
72RPS6KC10.76344594
73RPS6KL10.76344594
74TRPM70.75362036
75AKT30.72664373
76AKT20.69911736
77RPS6KA60.69695929
78CDK30.68531418
79CHEK20.66769037
80MAP2K70.66302024
81MAP2K60.65576408
82MST40.64713954
83SGK2230.63649950
84SGK4940.63649950
85FGFR30.62710187
86EEF2K0.62193581
87PRKCI0.60678560
88MYLK0.60486243
89MAPK120.57869414
90MAP3K100.55343530
91PTK20.54031936
92PIM10.53983141
93HIPK20.53950193
94PLK10.53884848
95PRKAA10.52132356
96CSK0.52048734
97KDR0.51130205
98GSK3A0.51021401
99PKN20.50162418
100SIK10.46212955
101SIK30.45017908
102LATS20.44464011
103PRKCD0.39028943
104MTOR0.38621387
105FLT30.37410110
106JAK30.37242979
107ALK0.36183395
108RPS6KA10.35685446
109IGF1R0.35400515
110SIK20.35110542
111VRK10.35024052
112PINK10.33178158
113PRKD20.31325815
114RIPK10.30579820
115DYRK1B0.28433525
116CHEK10.27485442
117PRKACG0.27291500
118PAK30.26984546
119IRAK10.26645260
120TXK0.26209016
121SGK30.25812721
122ITK0.25429668
123MAPK130.25062272
124LIMK10.24786007
125AURKA0.24489064
126CAMKK10.22517877
127LCK0.22435060
128LRRK20.22248568
129ERBB20.22068921
130MAPKAPK20.21074351
131EIF2AK20.20226944
132MST1R0.19996378
133CSNK1E0.19901579
134SGK20.19451050
135MAP3K10.18369757
136PDGFRA0.17829077
137CDK60.17222879
138IRAK40.16393586
139PDK10.15899371
140STK110.15621784
141BMX0.15430949
142MAPK10.15373021
143PRKCG0.15351865
144INSR0.15300344
145PRKACA0.14884076
146NEK20.14858788
147PDPK10.14179629
148EPHA40.13171647
149NEK60.13135771
150PRKAA20.12153295
151CDK20.11877095
152JAK20.11619204
153MAPK30.11617807
154ABL20.11269046
155MAP3K30.10804285
156NEK90.10676747
157PRKACB0.10537747
158FGFR40.09813015
159MAPK40.09724412
160PAK10.09236888
161STK160.09178315
162MAPK100.09014029
163CDK40.05728749
164LATS10.05710945
165RPS6KA30.05417711
166MAP3K90.05320571
167AURKB0.04997024
168TAOK10.04722551
169SGK10.04720295
170MAPK110.04522134
171DYRK1A0.03412134

Predicted pathways (KEGG)

RankGene SetZ-score
12-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.79244015
2Vitamin B6 metabolism_Homo sapiens_hsa007503.75543062
3Circadian rhythm_Homo sapiens_hsa047103.60004663
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.42671021
5Cyanoamino acid metabolism_Homo sapiens_hsa004603.31969547
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.27992893
7Pentose and glucuronate interconversions_Homo sapiens_hsa000403.06747139
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.06112619
9Butanoate metabolism_Homo sapiens_hsa006502.93957164
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.90926128
11Fructose and mannose metabolism_Homo sapiens_hsa000512.87644515
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.66716523
13Tryptophan metabolism_Homo sapiens_hsa003802.52991631
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.46774940
15Propanoate metabolism_Homo sapiens_hsa006402.29463196
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.14775489
17Vitamin digestion and absorption_Homo sapiens_hsa049772.14343073
18Peroxisome_Homo sapiens_hsa041462.02335669
19Malaria_Homo sapiens_hsa051442.00131695
20T cell receptor signaling pathway_Homo sapiens_hsa046601.97268259
21Osteoclast differentiation_Homo sapiens_hsa043801.93496986
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.90989704
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.89752631
24Leishmaniasis_Homo sapiens_hsa051401.88586121
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.86923505
26TNF signaling pathway_Homo sapiens_hsa046681.86095996
27Carbon metabolism_Homo sapiens_hsa012001.77627973
28Bile secretion_Homo sapiens_hsa049761.72342991
29B cell receptor signaling pathway_Homo sapiens_hsa046621.67597048
30ABC transporters_Homo sapiens_hsa020101.66355467
31Fatty acid degradation_Homo sapiens_hsa000711.65937726
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.65461390
33Legionellosis_Homo sapiens_hsa051341.61491949
34Arachidonic acid metabolism_Homo sapiens_hsa005901.60745825
35Measles_Homo sapiens_hsa051621.59757657
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.57345483
37Other glycan degradation_Homo sapiens_hsa005111.53923064
38Pyruvate metabolism_Homo sapiens_hsa006201.53730165
39Herpes simplex infection_Homo sapiens_hsa051681.52841906
40Toll-like receptor signaling pathway_Homo sapiens_hsa046201.52204949
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.52123267
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.49905111
43Glutathione metabolism_Homo sapiens_hsa004801.47877572
44Acute myeloid leukemia_Homo sapiens_hsa052211.45509046
45beta-Alanine metabolism_Homo sapiens_hsa004101.44737147
46Pertussis_Homo sapiens_hsa051331.40956227
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.40134567
48Protein digestion and absorption_Homo sapiens_hsa049741.37030233
49Galactose metabolism_Homo sapiens_hsa000521.35302857
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33889156
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.33805453
52Hepatitis C_Homo sapiens_hsa051601.33125800
53Biosynthesis of amino acids_Homo sapiens_hsa012301.32998089
54Collecting duct acid secretion_Homo sapiens_hsa049661.30685788
55Primary immunodeficiency_Homo sapiens_hsa053401.30200843
56Steroid biosynthesis_Homo sapiens_hsa001001.28555062
57Lysine degradation_Homo sapiens_hsa003101.25536674
58Influenza A_Homo sapiens_hsa051641.23923543
59PPAR signaling pathway_Homo sapiens_hsa033201.20803142
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19301351
61Longevity regulating pathway - mammal_Homo sapiens_hsa042111.19014682
62Selenocompound metabolism_Homo sapiens_hsa004501.16010094
63Fatty acid metabolism_Homo sapiens_hsa012121.14397094
64NF-kappa B signaling pathway_Homo sapiens_hsa040641.13602767
65Arginine biosynthesis_Homo sapiens_hsa002201.12296493
66Folate biosynthesis_Homo sapiens_hsa007901.12293686
67Prolactin signaling pathway_Homo sapiens_hsa049171.10383806
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.10044261
69Jak-STAT signaling pathway_Homo sapiens_hsa046301.09990911
70Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08700364
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.06793559
72Chemical carcinogenesis_Homo sapiens_hsa052041.03125372
73Apoptosis_Homo sapiens_hsa042101.01036402
74Hematopoietic cell lineage_Homo sapiens_hsa046401.00683349
75Sulfur metabolism_Homo sapiens_hsa009200.96276547
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.95074575
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94711974
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93312383
79Phototransduction_Homo sapiens_hsa047440.92071759
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91707282
81Arginine and proline metabolism_Homo sapiens_hsa003300.91117484
82Pentose phosphate pathway_Homo sapiens_hsa000300.90936295
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.87867384
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86683873
85p53 signaling pathway_Homo sapiens_hsa041150.85857210
86Amphetamine addiction_Homo sapiens_hsa050310.84116973
87Glycerolipid metabolism_Homo sapiens_hsa005610.83668784
88Renin-angiotensin system_Homo sapiens_hsa046140.83396993
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81913704
90Nitrogen metabolism_Homo sapiens_hsa009100.80398603
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.79755525
92Mineral absorption_Homo sapiens_hsa049780.79484144
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78787829
94Basal transcription factors_Homo sapiens_hsa030220.78165763
95Hepatitis B_Homo sapiens_hsa051610.78055948
96Viral carcinogenesis_Homo sapiens_hsa052030.77724284
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77577568
98Starch and sucrose metabolism_Homo sapiens_hsa005000.75093773
99cAMP signaling pathway_Homo sapiens_hsa040240.73458864
100Gastric acid secretion_Homo sapiens_hsa049710.72852639
101Sulfur relay system_Homo sapiens_hsa041220.72585401
102African trypanosomiasis_Homo sapiens_hsa051430.72290439
103Caffeine metabolism_Homo sapiens_hsa002320.71128837
104Colorectal cancer_Homo sapiens_hsa052100.70804829
105Estrogen signaling pathway_Homo sapiens_hsa049150.70449278
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68330085
107Long-term potentiation_Homo sapiens_hsa047200.64392580
108Linoleic acid metabolism_Homo sapiens_hsa005910.63227021
109Endometrial cancer_Homo sapiens_hsa052130.62906855
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.62656207
111Metabolic pathways_Homo sapiens_hsa011000.61656971
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60014966
113Oxytocin signaling pathway_Homo sapiens_hsa049210.54949436
114MAPK signaling pathway_Homo sapiens_hsa040100.53048733
115Insulin resistance_Homo sapiens_hsa049310.52990318
116Inositol phosphate metabolism_Homo sapiens_hsa005620.52654822
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52573087
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52157116
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.51807226
120Endocytosis_Homo sapiens_hsa041440.51552457
121Choline metabolism in cancer_Homo sapiens_hsa052310.51345305
122Nucleotide excision repair_Homo sapiens_hsa034200.50491365
123Dorso-ventral axis formation_Homo sapiens_hsa043200.50472400
124Cholinergic synapse_Homo sapiens_hsa047250.48542501
125HTLV-I infection_Homo sapiens_hsa051660.47701320
126Chemokine signaling pathway_Homo sapiens_hsa040620.46934249
127Lysosome_Homo sapiens_hsa041420.44078347
128Graft-versus-host disease_Homo sapiens_hsa053320.43389590
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43389328
130Retinol metabolism_Homo sapiens_hsa008300.42444950
131Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42368906
132mTOR signaling pathway_Homo sapiens_hsa041500.41613319
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.37748816
134Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37047649
135Rheumatoid arthritis_Homo sapiens_hsa053230.36542953
136Drug metabolism - other enzymes_Homo sapiens_hsa009830.35273476
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.35211663
138Salivary secretion_Homo sapiens_hsa049700.35003751
139Hedgehog signaling pathway_Homo sapiens_hsa043400.34796101
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34544521
141One carbon pool by folate_Homo sapiens_hsa006700.32706597
142Regulation of autophagy_Homo sapiens_hsa041400.32640630
143Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32540536
144Steroid hormone biosynthesis_Homo sapiens_hsa001400.30368905
145FoxO signaling pathway_Homo sapiens_hsa040680.30366290
146Histidine metabolism_Homo sapiens_hsa003400.30193709
147Prostate cancer_Homo sapiens_hsa052150.29902255
148Prion diseases_Homo sapiens_hsa050200.26531699
149Non-small cell lung cancer_Homo sapiens_hsa052230.25387149
150Thyroid cancer_Homo sapiens_hsa052160.24940353
151Shigellosis_Homo sapiens_hsa051310.24764052
152Glycerophospholipid metabolism_Homo sapiens_hsa005640.24612579
153Phospholipase D signaling pathway_Homo sapiens_hsa040720.24296497
154Amoebiasis_Homo sapiens_hsa051460.24079293
155Melanogenesis_Homo sapiens_hsa049160.23205153
156Epstein-Barr virus infection_Homo sapiens_hsa051690.23162278
157Chronic myeloid leukemia_Homo sapiens_hsa052200.23081998
158Serotonergic synapse_Homo sapiens_hsa047260.22989436
159Ovarian steroidogenesis_Homo sapiens_hsa049130.21496464
160Fatty acid elongation_Homo sapiens_hsa000620.19179835
161AMPK signaling pathway_Homo sapiens_hsa041520.18548451
162Bladder cancer_Homo sapiens_hsa052190.17017677
163Phenylalanine metabolism_Homo sapiens_hsa003600.16653578
164Ether lipid metabolism_Homo sapiens_hsa005650.13300149
165Carbohydrate digestion and absorption_Homo sapiens_hsa049730.11727328
166Tyrosine metabolism_Homo sapiens_hsa003500.11213905
167Maturity onset diabetes of the young_Homo sapiens_hsa049500.10731892
168Regulation of actin cytoskeleton_Homo sapiens_hsa048100.10248452
169Leukocyte transendothelial migration_Homo sapiens_hsa046700.08698176
170Tight junction_Homo sapiens_hsa045300.07095246
171Oxidative phosphorylation_Homo sapiens_hsa001900.06624996
172Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.05984390
173Adipocytokine signaling pathway_Homo sapiens_hsa049200.05568050
174Thyroid hormone signaling pathway_Homo sapiens_hsa049190.05380910
175Thyroid hormone synthesis_Homo sapiens_hsa049180.05217981
176Cardiac muscle contraction_Homo sapiens_hsa042600.05206008
177Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.04845079
178Central carbon metabolism in cancer_Homo sapiens_hsa052300.03041134

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