SLC22A14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 3. The encoded protein is a transmembrane protein which is thought to transport small molecules and since this protein is conserved among several species, it is suggested to have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.91500905
2epithelial cilium movement (GO:0003351)9.84621907
3spermatid development (GO:0007286)9.59442280
4reproduction (GO:0000003)9.49351052
5motile cilium assembly (GO:0044458)9.47351782
6regulation of cilium movement (GO:0003352)9.24523533
7dopamine transport (GO:0015872)9.24435014
8cilium movement (GO:0003341)8.14811199
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.59884387
10single fertilization (GO:0007338)7.58648503
11piRNA metabolic process (GO:0034587)7.45814207
12sperm capacitation (GO:0048240)7.27241582
13male meiosis (GO:0007140)7.21363925
14synaptonemal complex organization (GO:0070193)7.09189201
15synaptonemal complex assembly (GO:0007130)6.94356858
16catecholamine transport (GO:0051937)6.66621341
17negative regulation of inclusion body assembly (GO:0090084)6.61409975
18spermatogenesis (GO:0007283)6.54549761
19male gamete generation (GO:0048232)6.52189890
20NIK/NF-kappaB signaling (GO:0038061)6.51820032
21fertilization (GO:0009566)6.39216994
22microtubule depolymerization (GO:0007019)6.38205738
23prepulse inhibition (GO:0060134)6.28439519
24dopamine biosynthetic process (GO:0042416)6.16516538
25gamete generation (GO:0007276)5.99760409
26synaptic transmission, dopaminergic (GO:0001963)5.98265483
27phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)5.62126310
28regulation of inclusion body assembly (GO:0090083)5.59570877
29ventricular system development (GO:0021591)5.59370093
30negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.48515641
31regulation of microtubule-based movement (GO:0060632)5.45453327
32mating behavior (GO:0007617)5.42376280
33cellular process involved in reproduction in multicellular organism (GO:0022412)5.38641956
34germ cell development (GO:0007281)5.37609416
35calcium ion-dependent exocytosis (GO:0017156)5.32583184
36microtubule severing (GO:0051013)5.19054863
37cell recognition (GO:0008037)5.01688008
38male meiosis I (GO:0007141)4.83605439
39chromosome condensation (GO:0030261)4.76678263
40chromosome organization involved in meiosis (GO:0070192)4.76329677
41* organic cation transport (GO:0015695)4.75805519
42response to water (GO:0009415)4.74602591
43multicellular organismal reproductive process (GO:0048609)4.73204088
44adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.72815847
45DNA methylation involved in gamete generation (GO:0043046)4.71511735
46seminiferous tubule development (GO:0072520)4.68781606
47regulation of retinoic acid receptor signaling pathway (GO:0048385)4.66056726
48phenol-containing compound catabolic process (GO:0019336)4.61937041
49glycerol ether metabolic process (GO:0006662)4.56370156
50monoamine transport (GO:0015844)4.55902739
51DNA packaging (GO:0006323)4.51758977
52spermatid nucleus differentiation (GO:0007289)4.51045324
53urinary tract smooth muscle contraction (GO:0014848)4.37736448
54left/right pattern formation (GO:0060972)4.33987367
55meiotic nuclear division (GO:0007126)4.27469765
56ether metabolic process (GO:0018904)4.21853729
57I-kappaB phosphorylation (GO:0007252)4.19850969
58peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.17522930
59cellular response to pH (GO:0071467)4.11220723
60protein polyglutamylation (GO:0018095)4.03577697
61chaperone-mediated protein complex assembly (GO:0051131)3.91991450
62meiosis I (GO:0007127)3.84807662
63multicellular organismal development (GO:0007275)3.83089684
64snRNA transcription (GO:0009301)3.82111477
65neurotransmitter biosynthetic process (GO:0042136)3.80561122
66dopamine metabolic process (GO:0042417)3.76339667
67genitalia morphogenesis (GO:0035112)3.73489019
68outflow tract septum morphogenesis (GO:0003148)3.70850230
69catecholamine biosynthetic process (GO:0042423)3.67763100
70catechol-containing compound biosynthetic process (GO:0009713)3.67763100
71response to acidic pH (GO:0010447)3.59204307
72response to manganese ion (GO:0010042)3.58725558
73protein localization to cilium (GO:0061512)3.57041524
74monoubiquitinated protein deubiquitination (GO:0035520)3.56676757
75peristalsis (GO:0030432)3.53204240
76meiotic cell cycle (GO:0051321)3.52761113
77response to cocaine (GO:0042220)3.49135614
78single strand break repair (GO:0000012)3.46309515
79regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.43391064
80regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.43391064
81regulation of dopamine metabolic process (GO:0042053)3.37863583
82regulation of catecholamine metabolic process (GO:0042069)3.37863583
83protein K11-linked deubiquitination (GO:0035871)3.34572324
84sexual reproduction (GO:0019953)3.31496018
85regulation of spindle checkpoint (GO:0090231)3.28331077
86microtubule polymerization or depolymerization (GO:0031109)3.26747941
87sequestering of actin monomers (GO:0042989)3.22771764
88negative regulation of nitric-oxide synthase activity (GO:0051001)3.21572742
89amino-acid betaine transport (GO:0015838)3.15880458
90carnitine transport (GO:0015879)3.15880458
91establishment of protein localization to Golgi (GO:0072600)3.14766537
92glycolytic process (GO:0006096)3.14297526
93regulation of female receptivity (GO:0045924)3.12302326
94long term synaptic depression (GO:0060292)3.10264383
95positive regulation of Rab GTPase activity (GO:0032851)3.09277745
96regulation of Rab GTPase activity (GO:0032313)3.09277745
97protein targeting to Golgi (GO:0000042)3.07698759
98retrograde transport, vesicle recycling within Golgi (GO:0000301)3.07656612
99cellular response to nicotine (GO:0071316)3.03032711
100nucleus organization (GO:0006997)3.02882585
101protein refolding (GO:0042026)3.02628362
102interferon-gamma secretion (GO:0072643)3.02368442
103extracellular matrix assembly (GO:0085029)3.01088399
104positive regulation of protein homooligomerization (GO:0032464)3.00980163
105regulation of transmission of nerve impulse (GO:0051969)3.00867981
106carnitine transmembrane transport (GO:1902603)3.00603348
107nucleoside diphosphate phosphorylation (GO:0006165)3.00122011
108regulation of female gonad development (GO:2000194)2.99953535
109polyol catabolic process (GO:0046174)2.99820611
110mitotic sister chromatid cohesion (GO:0007064)2.93995982
111cellular response to catecholamine stimulus (GO:0071870)2.91193502
112cellular response to monoamine stimulus (GO:0071868)2.91193502
113regulation of response to osmotic stress (GO:0047484)2.90455848
114alditol metabolic process (GO:0019400)2.89574760
115dopamine receptor signaling pathway (GO:0007212)2.89208282
116RNA localization (GO:0006403)2.89024180
117cilium organization (GO:0044782)2.88466091
118behavioral response to cocaine (GO:0048148)2.87031951
119alkaloid metabolic process (GO:0009820)2.86071112
120response to amphetamine (GO:0001975)2.84454046
121synapsis (GO:0007129)2.84097694
122sodium ion export (GO:0071436)2.82421084
123microtubule-based movement (GO:0007018)2.81747059
124meiotic cell cycle process (GO:1903046)2.80021931
125intraciliary transport (GO:0042073)2.78941715
126cilium assembly (GO:0042384)2.77115542
127protein depolymerization (GO:0051261)2.76487294
128gene silencing by RNA (GO:0031047)2.76111825
129response to insecticide (GO:0017085)2.75858419
130transmission of nerve impulse (GO:0019226)2.75620259
131cellular component assembly involved in morphogenesis (GO:0010927)2.75538511
132cilium morphogenesis (GO:0060271)2.74854082
133negative regulation of organelle assembly (GO:1902116)2.73175356
134axoneme assembly (GO:0035082)2.72734521
135ovulation from ovarian follicle (GO:0001542)2.72689787
136tyrosine metabolic process (GO:0006570)2.70427896
137positive regulation of macrophage activation (GO:0043032)2.70136962
138plasma membrane repair (GO:0001778)2.69178416
139lactate metabolic process (GO:0006089)2.68877468
140peptidyl-glutamic acid modification (GO:0018200)2.68704891
141vitamin transmembrane transport (GO:0035461)2.67107374
142GTP biosynthetic process (GO:0006183)2.66635341
143nuclear pore complex assembly (GO:0051292)2.65584634
144astrocyte development (GO:0014002)2.65201013
145regulation of cilium assembly (GO:1902017)2.65147220
146growth hormone secretion (GO:0030252)2.62152565
147cytoskeletal anchoring at plasma membrane (GO:0007016)2.59526068
148response to monoamine (GO:0071867)2.57560450
149response to catecholamine (GO:0071869)2.57560450
150norepinephrine metabolic process (GO:0042415)2.55426511
151metanephric mesenchyme development (GO:0072075)2.54827001
152peripheral nervous system neuron development (GO:0048935)2.54647593
153membrane depolarization during action potential (GO:0086010)2.53882225
154paraxial mesoderm development (GO:0048339)2.52167465
155RNA destabilization (GO:0050779)2.50684409
156cell volume homeostasis (GO:0006884)2.49747918
157protein localization to chromosome, centromeric region (GO:0071459)2.48684562
158multicellular organismal movement (GO:0050879)2.46933687
159musculoskeletal movement (GO:0050881)2.46933687
160grooming behavior (GO:0007625)2.46667731
161female mating behavior (GO:0060180)2.44968523
162myoblast fusion (GO:0007520)2.44572621
163fibril organization (GO:0097435)2.43363262
164regulation of ARF GTPase activity (GO:0032312)2.43058554
165glycerol metabolic process (GO:0006071)2.42419298
166glutamate secretion (GO:0014047)2.40062138
167neurotransmitter metabolic process (GO:0042133)2.39889950
168synaptic vesicle docking involved in exocytosis (GO:0016081)2.39284890
169barbed-end actin filament capping (GO:0051016)2.38973505
170metanephric tubule development (GO:0072170)2.38720032
171metanephric nephron tubule development (GO:0072234)2.38720032
172bone trabecula formation (GO:0060346)2.37888626
173fusion of sperm to egg plasma membrane (GO:0007342)13.8398758
174sperm motility (GO:0030317)13.5590930
175cell wall macromolecule catabolic process (GO:0016998)12.8030160
176cell wall macromolecule metabolic process (GO:0044036)12.8030160
177acrosome assembly (GO:0001675)11.8464376
178acrosome reaction (GO:0007340)11.7806226
179sperm-egg recognition (GO:0035036)11.6277967
180multicellular organism reproduction (GO:0032504)11.2588106
181plasma membrane fusion (GO:0045026)10.5251694
182binding of sperm to zona pellucida (GO:0007339)10.5127494
183cell-cell recognition (GO:0009988)10.3936962
184axonemal dynein complex assembly (GO:0070286)10.0155946

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.26785106
2EZH2_22144423_ChIP-Seq_EOC_Human3.95830831
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.06472647
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.93672959
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.86260745
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.79980763
7GBX2_23144817_ChIP-Seq_PC3_Human2.63489993
8DROSHA_22980978_ChIP-Seq_HELA_Human2.58005300
9VDR_22108803_ChIP-Seq_LS180_Human2.35343611
10CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.25248243
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.12553121
12GATA1_26923725_Chip-Seq_HPCs_Mouse2.11767991
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.11728711
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.1428793
15EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.99769202
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97683253
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.97090188
18JARID2_20075857_ChIP-Seq_MESCs_Mouse1.95969726
19ELK4_26923725_Chip-Seq_MESODERM_Mouse1.89440341
20ZNF274_21170338_ChIP-Seq_K562_Hela1.88368184
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.87570735
22KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.86841130
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.83542420
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.82826046
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81003313
26FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75931844
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.72265979
28TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.69696925
29MTF2_20144788_ChIP-Seq_MESCs_Mouse1.69440022
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.69290660
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.66744592
32STAT1_17558387_ChIP-Seq_HELA_Human1.65931172
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65528467
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63813124
35MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.63729374
36VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.63094311
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.61252695
38AR_21572438_ChIP-Seq_LNCaP_Human1.61155623
39SOX2_22085726_ChIP-Seq_NPCs_Mouse1.56984333
40WDR5_24793694_ChIP-Seq_LNCAP_Human1.56704810
41GATA3_21867929_ChIP-Seq_CD8_Mouse1.55968091
42GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.54328997
43JARID2_20064375_ChIP-Seq_MESCs_Mouse1.51982744
44SMC4_20622854_ChIP-Seq_HELA_Human1.48376170
45RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.47155060
46KAP1_22055183_ChIP-Seq_ESCs_Mouse1.46672778
47SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44497571
48RNF2_18974828_ChIP-Seq_MESCs_Mouse1.43186389
49EZH2_18974828_ChIP-Seq_MESCs_Mouse1.43186389
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.43181495
51TAL1_26923725_Chip-Seq_HPCs_Mouse1.40173241
52CBP_20019798_ChIP-Seq_JUKART_Human1.38870075
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38870075
54PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.37223948
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34937941
56KDM2B_26808549_Chip-Seq_REH_Human1.34443866
57CJUN_26792858_Chip-Seq_BT549_Human1.34267322
58LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.33329101
59SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.32850702
60* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.32255444
61EED_16625203_ChIP-ChIP_MESCs_Mouse1.32179627
62GATA2_21666600_ChIP-Seq_HMVEC_Human1.32004874
63PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31869073
64ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.30727664
65STAT3_23295773_ChIP-Seq_U87_Human1.30497262
66CTCF_27219007_Chip-Seq_Bcells_Human1.29247447
67SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.28506777
68SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.25469571
69RARG_19884340_ChIP-ChIP_MEFs_Mouse1.25330288
70TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24239933
71REST_21632747_ChIP-Seq_MESCs_Mouse1.23832355
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.23428980
73RNF2_27304074_Chip-Seq_ESCs_Mouse1.22680708
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22242078
75* P53_21459846_ChIP-Seq_SAOS-2_Human1.22080066
76GF1_26923725_Chip-Seq_HPCs_Mouse1.21984281
77TP53_18474530_ChIP-ChIP_U2OS_Human1.21112072
78CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20450221
79* GATA3_21867929_ChIP-Seq_TH1_Mouse1.19962389
80CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18781500
81SPI1_26923725_Chip-Seq_HPCs_Mouse1.18736705
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.18726879
83RUNX1_26923725_Chip-Seq_HPCs_Mouse1.18281590
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17196861
85RAD21_21589869_ChIP-Seq_MESCs_Mouse1.17136888
86ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16780874
87EZH2_27304074_Chip-Seq_ESCs_Mouse1.16683401
88P68_20966046_ChIP-Seq_HELA_Human1.16620770
89SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15335215
90SMAD_19615063_ChIP-ChIP_OVARY_Human1.15281195
91TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15140216
92* TP63_22573176_ChIP-Seq_HFKS_Human1.14122913
93SMAD4_21799915_ChIP-Seq_A2780_Human1.13265463
94JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12545551
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12274344
96TP53_16413492_ChIP-PET_HCT116_Human1.11894636
97CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11553226
98* TCF4_23295773_ChIP-Seq_U87_Human1.11455547
99GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11137194
100ESET_19884257_ChIP-Seq_ESCs_Mouse1.11013094
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10884857
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10587461
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10587461
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09858124
105KLF4_19829295_ChIP-Seq_ESCs_Human1.09541424
106CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09352148
107RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09163669
108ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09117575
109JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08837722
110RXRA_24833708_ChIP-Seq_LIVER_Mouse1.08738442
111RAC3_21632823_ChIP-Seq_H3396_Human1.08368589
112RNF2_27304074_Chip-Seq_NSC_Mouse1.08040135
113EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.07780803
114ERG_20517297_ChIP-Seq_VCAP_Human1.06810160
115VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06169129
116TBL1_22424771_ChIP-Seq_293T_Human1.05973388
117YY1_22570637_ChIP-Seq_MALME-3M_Human1.05762347
118ARNT_22903824_ChIP-Seq_MCF-7_Human1.04433309
119AHR_22903824_ChIP-Seq_MCF-7_Human1.04419370
120CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04276185
121OCT4_19829295_ChIP-Seq_ESCs_Human1.04244240
122TP53_22127205_ChIP-Seq_IMR90_Human1.03884090
123* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03529469
124PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.03285142
125SMAD4_21741376_ChIP-Seq_HESCs_Human1.02957665
126EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02718043
127RARA_24833708_ChIP-Seq_LIVER_Mouse1.02525648
128TAF15_26573619_Chip-Seq_HEK293_Human1.01994085
129IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00802056
130KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.00563685
131KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00563685
132KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00563685
133CRX_20693478_ChIP-Seq_RETINA_Mouse1.00533696
134* MYC_27129775_Chip-Seq_CORNEA_Mouse1.00455112
135GATA1_19941827_ChIP-Seq_MEL86_Mouse0.99728137
136AR_25329375_ChIP-Seq_VCAP_Human0.99242552
137ELF1_20517297_ChIP-Seq_JURKAT_Human0.98999913
138TDRD3_21172665_ChIP-Seq_MCF-7_Human0.98512665
139TP53_23651856_ChIP-Seq_MEFs_Mouse0.97652543
140SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97620439
141NANOG_18555785_Chip-Seq_ESCs_Mouse0.97378416
142OCT4_18555785_Chip-Seq_ESCs_Mouse0.97074219
143STAT3_18555785_ChIP-Seq_MESCs_Mouse0.96755868
144LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96444013
145WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96117191
146BCAT_22108803_ChIP-Seq_LS180_Human0.95614086
147NFYB_21822215_ChIP-Seq_K562_Human0.95513828
148RXR_22108803_ChIP-Seq_LS180_Human0.94390176
149TET1_21451524_ChIP-Seq_MESCs_Mouse0.94327914
150CTCF_20526341_ChIP-Seq_ESCs_Human0.93746874
151SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93169551
152CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92905667
153ESR2_21235772_ChIP-Seq_MCF-7_Human0.92362998
154FLI1_21867929_ChIP-Seq_CD8_Mouse0.92028810
155TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91947389
156JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.91566126
157SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91279223
158TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91080688
159* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90566230
160NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90394009
161UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90016400
162KLF4_18555785_Chip-Seq_ESCs_Mouse0.89452434
163TET1_21490601_ChIP-Seq_MESCs_Mouse0.89190987
164* TAF2_19829295_ChIP-Seq_ESCs_Human0.88701906
165AR_19668381_ChIP-Seq_PC3_Human0.88491645
166SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88387495
167HNFA_21074721_ChIP-Seq_CACO-2_Human0.87965866
168RARB_27405468_Chip-Seq_BRAIN_Mouse0.87773551
169LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87653390
170ESRRB_18555785_Chip-Seq_ESCs_Mouse0.87252721
171NANOG_20526341_ChIP-Seq_ESCs_Human0.87222475
172PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.87126770
173PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87112009
174CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.87046814
175OCT4_20526341_ChIP-Seq_ESCs_Human0.86774774
176TCF4_18268006_ChIP-ChIP_LS174T_Human0.86382245
177P53_22387025_ChIP-Seq_ESCs_Mouse0.86172573
178PHF8_20622854_ChIP-Seq_HELA_Human0.86156940
179CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86058923
180CMYC_18555785_Chip-Seq_ESCs_Mouse0.85690876
181BCOR_27268052_Chip-Seq_Bcells_Human0.85357931
182* SOX11_22085726_ChIP-Seq_ESNs_Mouse0.85061153
183SOX2_21211035_ChIP-Seq_LN229_Human0.84851782

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.01057129
2MP0001929_abnormal_gametogenesis5.48413097
3MP0008877_abnormal_DNA_methylation3.99611277
4MP0001905_abnormal_dopamine_level3.69534216
5MP0002210_abnormal_sex_determination3.39047839
6MP0002161_abnormal_fertility/fecundity3.27546950
7MP0002254_reproductive_system_inflammat3.23584981
8MP0003879_abnormal_hair_cell3.06024408
9MP0003283_abnormal_digestive_organ2.99991103
10MP0001145_abnormal_male_reproductive2.91453478
11MP0002653_abnormal_ependyma_morphology2.82658962
12MP0005670_abnormal_white_adipose2.80296433
13MP0008438_abnormal_cutaneous_collagen2.65900441
14MP0000653_abnormal_sex_gland2.49641600
15MP0001986_abnormal_taste_sensitivity2.46939381
16MP0002837_dystrophic_cardiac_calcinosis2.38121111
17MP0005423_abnormal_somatic_nervous2.33100411
18MP0005275_abnormal_skin_tensile2.29201526
19MP0001968_abnormal_touch/_nociception2.20828951
20MP0005410_abnormal_fertilization16.3375896
21MP0000749_muscle_degeneration1.97415083
22MP0005595_abnormal_vascular_smooth1.79757622
23MP0002735_abnormal_chemical_nociception1.76772520
24MP0005623_abnormal_meninges_morphology1.72232881
25MP0010386_abnormal_urinary_bladder1.69769222
26MP0003635_abnormal_synaptic_transmissio1.64911827
27MP0005171_absent_coat_pigmentation1.63876226
28MP0008004_abnormal_stomach_pH1.62288329
29MP0002160_abnormal_reproductive_system1.62284174
30MP0003705_abnormal_hypodermis_morpholog1.59065924
31MP0003279_aneurysm1.56788551
32MP0003091_abnormal_cell_migration1.55679714
33MP0010368_abnormal_lymphatic_system1.52419113
34MP0003646_muscle_fatigue1.51254197
35MP0002282_abnormal_trachea_morphology1.48478598
36MP0003566_abnormal_cell_adhesion1.48154778
37MP0000230_abnormal_systemic_arterial1.45365052
38MP0002572_abnormal_emotion/affect_behav1.42540994
39MP0009745_abnormal_behavioral_response1.42060955
40MP0004859_abnormal_synaptic_plasticity1.41504193
41MP0001958_emphysema1.41445574
42MP0001881_abnormal_mammary_gland1.41018591
43MP0002332_abnormal_exercise_endurance1.39289984
44MP0006276_abnormal_autonomic_nervous1.38843697
45MP0002063_abnormal_learning/memory/cond1.37229016
46MP0003011_delayed_dark_adaptation1.32800689
47MP0003136_yellow_coat_color1.29950363
48MP0000751_myopathy1.29503376
49MP0002168_other_aberrant_phenotype1.27578873
50MP0004233_abnormal_muscle_weight1.25497105
51MP0001486_abnormal_startle_reflex1.23606290
52MP0002272_abnormal_nervous_system1.23301579
53MP0005167_abnormal_blood-brain_barrier1.21262840
54MP0004272_abnormal_basement_membrane1.16961024
55MP0001440_abnormal_grooming_behavior1.14629125
56MP0001661_extended_life_span1.12401851
57MP0003828_pulmonary_edema1.12326375
58MP0000462_abnormal_digestive_system1.10519339
59MP0008872_abnormal_physiological_respon1.10379365
60MP0008260_abnormal_autophagy1.07012578
61MP0001765_abnormal_ion_homeostasis1.06123521
62MP0008874_decreased_physiological_sensi1.05815310
63MP0001501_abnormal_sleep_pattern1.05633507
64MP0001664_abnormal_digestion1.05222873
65MP0004084_abnormal_cardiac_muscle1.04297959
66MP0005386_behavior/neurological_phenoty1.04019140
67MP0004924_abnormal_behavior1.04019140
68MP0005620_abnormal_muscle_contractility1.00857714
69MP0002067_abnormal_sensory_capabilities0.99527977
70MP0002822_catalepsy0.99042734
71MP0000767_abnormal_smooth_muscle0.98726986
72MP0002064_seizures0.97663841
73MP0001984_abnormal_olfaction0.95110069
74MP0008569_lethality_at_weaning0.94337513
75MP0005395_other_phenotype0.93312072
76MP0005409_darkened_coat_color0.91931463
77MP0008058_abnormal_DNA_repair0.91087673
78MP0005647_abnormal_sex_gland0.90927457
79MP0005164_abnormal_response_to0.90864333
80MP0009046_muscle_twitch0.89766002
81MP0001970_abnormal_pain_threshold0.85862746
82MP0005330_cardiomyopathy0.85842787
83MP0000013_abnormal_adipose_tissue0.81042245
84MP0005389_reproductive_system_phenotype0.80198787
85MP0005535_abnormal_body_temperature0.77771097
86MP0005375_adipose_tissue_phenotype0.77339317
87MP0008995_early_reproductive_senescence0.75470918
88MP0003385_abnormal_body_wall0.74810612
89MP0003195_calcinosis0.74521536
90MP0002557_abnormal_social/conspecific_i0.74309121
91MP0005023_abnormal_wound_healing0.73078476
92MP0003632_abnormal_nervous_system0.73004199
93MP0000733_abnormal_muscle_development0.72444405
94MP0000249_abnormal_blood_vessel0.71273090
95MP0002234_abnormal_pharynx_morphology0.71268451
96MP0005503_abnormal_tendon_morphology0.71077561
97MP0005310_abnormal_salivary_gland0.71046331
98MP0006138_congestive_heart_failure0.68646988
99MP0008057_abnormal_DNA_replication0.68614990
100MP0003115_abnormal_respiratory_system0.67006223
101MP0000470_abnormal_stomach_morphology0.66749124
102MP0002733_abnormal_thermal_nociception0.64283540
103MP0001293_anophthalmia0.63516556
104MP0005377_hearing/vestibular/ear_phenot0.62870524
105MP0003878_abnormal_ear_physiology0.62870524
106MP0000750_abnormal_muscle_regeneration0.62817005
107MP0000759_abnormal_skeletal_muscle0.62766292
108MP0010094_abnormal_chromosome_stability0.61865050
109MP0003631_nervous_system_phenotype0.59183405
110MP0005666_abnormal_adipose_tissue0.58510256
111MP0000358_abnormal_cell_content/0.56020573
112MP0001324_abnormal_eye_pigmentation0.53081483
113MP0005636_abnormal_mineral_homeostasis0.52144405
114MP0003950_abnormal_plasma_membrane0.48622272
115MP0002269_muscular_atrophy0.48571648
116MP0003699_abnormal_female_reproductive0.47413040
117MP0005253_abnormal_eye_physiology0.45280615
118MP0008961_abnormal_basal_metabolism0.44167524
119MP0009115_abnormal_fat_cell0.42413418
120MP0003786_premature_aging0.42111304
121MP0006035_abnormal_mitochondrial_morpho0.41414034
122MP0005391_vision/eye_phenotype0.41083448
123MP0002928_abnormal_bile_duct0.40678633
124MP0004036_abnormal_muscle_relaxation0.40441669
125MP0000534_abnormal_ureter_morphology0.39715222
126MP0003111_abnormal_nucleus_morphology0.39547088
127MP0006036_abnormal_mitochondrial_physio0.38349244
128MP0001545_abnormal_hematopoietic_system0.37901306
129MP0005397_hematopoietic_system_phenotyp0.37901306
130MP0004133_heterotaxia0.37763678
131MP0000569_abnormal_digit_pigmentation0.37336235
132MP0004264_abnormal_extraembryonic_tissu0.35600940
133MP0003942_abnormal_urinary_system0.35541558
134MP0003329_amyloid_beta_deposits0.35444766
135MP0002092_abnormal_eye_morphology0.32462991
136MP0005551_abnormal_eye_electrophysiolog0.32372064
137MP0001730_embryonic_growth_arrest0.32245999
138MP0008007_abnormal_cellular_replicative0.32123811
139MP0009278_abnormal_bone_marrow0.31725633
140MP0001764_abnormal_homeostasis0.30207267
141MP0001119_abnormal_female_reproductive0.29733251
142MP0001672_abnormal_embryogenesis/_devel0.29339817
143MP0005380_embryogenesis_phenotype0.29339817
144MP0004043_abnormal_pH_regulation0.28857132
145MP0003861_abnormal_nervous_system0.27569500
146MP0001849_ear_inflammation0.26826152
147MP0002971_abnormal_brown_adipose0.26127532
148MP0003787_abnormal_imprinting0.25473819
149MP0002084_abnormal_developmental_patter0.25331036
150MP0000313_abnormal_cell_death0.23698870
151MP0001270_distended_abdomen0.23678769
152MP0003183_abnormal_peptide_metabolism0.23426811
153MP0003984_embryonic_growth_retardation0.23148514
154MP0002088_abnormal_embryonic_growth/wei0.21460560
155MP0004019_abnormal_vitamin_homeostasis0.21356746
156MP0003890_abnormal_embryonic-extraembry0.21079671
157MP0000432_abnormal_head_morphology0.20816476
158MP0002132_abnormal_respiratory_system0.20591982
159MP0002295_abnormal_pulmonary_circulatio0.19893552
160MP0001727_abnormal_embryo_implantation0.19519204
161MP0003633_abnormal_nervous_system0.19428693
162MP0002102_abnormal_ear_morphology0.19087066
163MP0002970_abnormal_white_adipose0.18453357
164MP0002169_no_abnormal_phenotype0.18445702
165MP0002873_normal_phenotype0.18126914
166MP0002152_abnormal_brain_morphology0.17492458
167MP0004811_abnormal_neuron_physiology0.17486867
168MP0009250_abnormal_appendicular_skeleto0.17473720
169MP0002736_abnormal_nociception_after0.17408961
170MP0005319_abnormal_enzyme/_coenzyme0.17239585
171MP0010307_abnormal_tumor_latency0.17152113
172MP0003948_abnormal_gas_homeostasis0.16786771
173MP0001348_abnormal_lacrimal_gland0.16181311
174MP0002909_abnormal_adrenal_gland0.15857258
175MP0001697_abnormal_embryo_size0.15847939
176MP0002108_abnormal_muscle_morphology0.15775544
177MP0005257_abnormal_intraocular_pressure0.15349430
178MP0002085_abnormal_embryonic_tissue0.15332348
179MP0003045_fibrosis0.15158831

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.33289432
2Abnormal respiratory epithelium morphology (HP:0012253)9.07410221
3Abnormal respiratory motile cilium morphology (HP:0005938)9.07410221
4Rhinitis (HP:0012384)7.60924735
5Limb dystonia (HP:0002451)7.60044345
6Abnormal ciliary motility (HP:0012262)7.41713254
7Chronic bronchitis (HP:0004469)7.38878443
8Infertility (HP:0000789)6.76971692
9Nasal polyposis (HP:0100582)6.60937591
10Parkinsonism with favorable response to dopaminergic medication (HP:0002548)6.32991544
11Abnormality of the nasal mucosa (HP:0000433)5.43934232
12Aortic aneurysm (HP:0004942)4.66502063
13Bronchitis (HP:0012387)4.64544194
14Male infertility (HP:0003251)4.61011573
15Bronchiectasis (HP:0002110)4.43281152
16Postural instability (HP:0002172)4.20255436
17Nephronophthisis (HP:0000090)4.06387205
18Ulnar bowing (HP:0003031)4.01594075
19Focal motor seizures (HP:0011153)3.87650746
20Short chin (HP:0000331)3.61430241
21Hypokinesia (HP:0002375)3.53971692
22Abnormal spermatogenesis (HP:0008669)3.47759363
23Recurrent otitis media (HP:0000403)3.30465505
24Recurrent sinusitis (HP:0011108)3.27900343
25Febrile seizures (HP:0002373)3.19093271
26Aortic dissection (HP:0002647)3.12142364
27Abnormality of the renal medulla (HP:0100957)3.05606238
28Rigidity (HP:0002063)2.99868336
29Supranuclear gaze palsy (HP:0000605)2.95363601
30Impulsivity (HP:0100710)2.91335211
31Recurrent bronchitis (HP:0002837)2.81654695
32Delayed gross motor development (HP:0002194)2.77309262
33Atrophic scars (HP:0001075)2.72709985
34Bradykinesia (HP:0002067)2.67201926
35Distal upper limb amyotrophy (HP:0007149)2.66483547
36Upper limb amyotrophy (HP:0009129)2.66483547
37Tubulointerstitial nephritis (HP:0001970)2.66173902
38Abnormality of midbrain morphology (HP:0002418)2.63333599
39Molar tooth sign on MRI (HP:0002419)2.63333599
40Increased connective tissue (HP:0009025)2.62983556
41Cerebral aneurysm (HP:0004944)2.60867220
42Amelogenesis imperfecta (HP:0000705)2.51327049
43Focal seizures (HP:0007359)2.48308478
44Severe visual impairment (HP:0001141)2.47520354
45Tubular atrophy (HP:0000092)2.46434406
46Abnormality of the periventricular white matter (HP:0002518)2.46333194
47Bowed forearm bones (HP:0003956)2.44374098
48Bowing of the arm (HP:0006488)2.44374098
49Potter facies (HP:0002009)2.43151123
50Facial shape deformation (HP:0011334)2.43151123
51Type 1 muscle fiber predominance (HP:0003803)2.41739739
52Gonadotropin excess (HP:0000837)2.39577766
53Medial flaring of the eyebrow (HP:0010747)2.35338095
54Hyperkalemia (HP:0002153)2.33822255
55Keratoconjunctivitis sicca (HP:0001097)2.32836375
56Congenital sensorineural hearing impairment (HP:0008527)2.30104596
57Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.28065323
58Tubulointerstitial abnormality (HP:0001969)2.28036475
59Mask-like facies (HP:0000298)2.27679739
60Prolonged QT interval (HP:0001657)2.26975866
61Dialeptic seizures (HP:0011146)2.26238286
62Persistence of primary teeth (HP:0006335)2.26236847
63Muscle fiber splitting (HP:0003555)2.22205401
64Abnormal gallbladder physiology (HP:0012438)2.22183808
65Cholecystitis (HP:0001082)2.22183808
66Abnormality of the ischium (HP:0003174)2.21125610
67Dyschromatopsia (HP:0007641)2.21041325
68Azoospermia (HP:0000027)2.19797671
69Hand muscle atrophy (HP:0009130)2.19202792
70Mitral stenosis (HP:0001718)2.18933128
71Portal hypertension (HP:0001409)2.18719401
72Bronchomalacia (HP:0002780)2.16333530
73Radial bowing (HP:0002986)2.16281545
74Striae distensae (HP:0001065)2.12782139
75Hydroureter (HP:0000072)2.12719587
76Patent foramen ovale (HP:0001655)2.12097538
77Spastic tetraparesis (HP:0001285)2.10335058
78Keratoconjunctivitis (HP:0001096)2.10016705
79Peritonitis (HP:0002586)2.09509738
80Bony spicule pigmentary retinopathy (HP:0007737)2.07620236
81Abnormality of the lower motor neuron (HP:0002366)2.07517184
82Scapular winging (HP:0003691)2.04191534
83Insulin-resistant diabetes mellitus (HP:0000831)2.02427804
84Ventricular fibrillation (HP:0001663)2.01759888
85Protrusio acetabuli (HP:0003179)2.01253043
86Broad face (HP:0000283)2.00555567
87Progressive cerebellar ataxia (HP:0002073)2.00505078
88Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.3194986
89Dynein arm defect of respiratory motile cilia (HP:0012255)13.1890398
90Absent/shortened dynein arms (HP:0200106)13.1890398
91Esophageal varix (HP:0002040)1.99286108
92Hypercortisolism (HP:0001578)1.98465859
93Morphological abnormality of the pyramidal tract (HP:0002062)1.94612667
94Abnormality of the hepatic vasculature (HP:0006707)1.94305458
95Abnormality of binocular vision (HP:0011514)1.93082420
96Diplopia (HP:0000651)1.93082420
97Difficulty walking (HP:0002355)1.92715307
98Diminished movement (HP:0002374)1.91136323
99Coronal craniosynostosis (HP:0004440)1.89870781
100Myotonia (HP:0002486)1.89736444
101Mitral valve prolapse (HP:0001634)1.87691846
102Tubulointerstitial fibrosis (HP:0005576)1.85902623
103Postaxial foot polydactyly (HP:0001830)1.84850350
104Atonic seizures (HP:0010819)1.83986085
105Absence seizures (HP:0002121)1.83687071
106Dyskinesia (HP:0100660)1.82748908
107Gastrointestinal dysmotility (HP:0002579)1.81929173
108Hypoplasia of the capital femoral epiphysis (HP:0003090)1.81708101
109Heterotopia (HP:0002282)1.81528521
110Preauricular pit (HP:0004467)1.80566860
111Periauricular skin pits (HP:0100277)1.80566860
112Exercise-induced myalgia (HP:0003738)1.79591219
113Abnormality of the calf musculature (HP:0001430)1.79262075
114Bile duct proliferation (HP:0001408)1.76780745
115Abnormal biliary tract physiology (HP:0012439)1.76780745
116Decreased central vision (HP:0007663)1.75774903
117Abnormality of saccadic eye movements (HP:0000570)1.74492946
118Fibular hypoplasia (HP:0003038)1.73569894
119Progressive sensorineural hearing impairment (HP:0000408)1.73059032
120Glossoptosis (HP:0000162)1.72591558
121Syncope (HP:0001279)1.72049957
122Choroideremia (HP:0001139)1.71982249
123Short ribs (HP:0000773)1.71929215
124Congenital hepatic fibrosis (HP:0002612)1.71430630
125Hyporeflexia of lower limbs (HP:0002600)1.70995899
126Ankle contracture (HP:0006466)1.69808610
127Stage 5 chronic kidney disease (HP:0003774)1.68795519
128Broad metatarsal (HP:0001783)1.68136500
129Decreased subcutaneous fat (HP:0001002)1.67779583
130Absent frontal sinuses (HP:0002688)1.67050661
131Bradycardia (HP:0001662)1.66320993
132Centrally nucleated skeletal muscle fibers (HP:0003687)1.65339648
133Amyotrophic lateral sclerosis (HP:0007354)1.65255547
134Polydipsia (HP:0001959)1.65213652
135Abnormal drinking behavior (HP:0030082)1.65213652
136Aneurysm (HP:0002617)1.64843454
137Joint stiffness (HP:0001387)1.63554751
138Rapidly progressive (HP:0003678)1.63341018
139Glucose intolerance (HP:0000833)1.63237103
140Facial cleft (HP:0002006)1.63206385
141Absent hand (HP:0004050)1.63039876
142Type I diabetes mellitus (HP:0100651)1.62817031
143Wrist flexion contracture (HP:0001239)1.61759452
144Dysmetric saccades (HP:0000641)1.61569007
145Atrial fibrillation (HP:0005110)1.61122272
146Absent epiphyses (HP:0010577)1.58435036
147Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.58435036
148Abnormality of renal excretion (HP:0011036)1.53833651
149Oculomotor apraxia (HP:0000657)1.53056146
150Abnormality of permanent molar morphology (HP:0011071)1.52863921
151Abnormality of the dental root (HP:0006486)1.52863921
152Taurodontia (HP:0000679)1.52863921
153Bell-shaped thorax (HP:0001591)1.52727514
154Abnormality of the renal cortex (HP:0011035)1.52281735
155Abnormality of dentin (HP:0010299)1.52063759
156Postaxial hand polydactyly (HP:0001162)1.49455802
157Hemorrhage of the eye (HP:0011885)1.48722645
158Renal dysplasia (HP:0000110)1.44591351
159Aplasia/Hypoplasia of the lens (HP:0008063)1.41651668
160Abnormality of molar morphology (HP:0011070)1.41260378
161Abnormality of molar (HP:0011077)1.41260378
162Abnormality of the dental pulp (HP:0006479)1.39894588
163Hemiparesis (HP:0001269)1.39481093
164Short thorax (HP:0010306)1.35774204
165Impaired proprioception (HP:0010831)1.35486597
166Supernumerary spleens (HP:0009799)1.35375170
167Neurofibrillary tangles (HP:0002185)1.31756576
168Deformed sella turcica (HP:0002681)1.31569843
169Short femoral neck (HP:0100864)1.28385411
170Chronic sinusitis (HP:0011109)1.27914904
171Congenital primary aphakia (HP:0007707)1.27297130
172Sensory axonal neuropathy (HP:0003390)1.26810252
173Gait imbalance (HP:0002141)1.26407305
174Cystic liver disease (HP:0006706)1.25754128
175Microglossia (HP:0000171)1.25633702
176Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.24392646
177Abnormal urine output (HP:0012590)1.22818508
178Decreased electroretinogram (ERG) amplitude (HP:0000654)1.22529999
179Congenital malformation of the right heart (HP:0011723)1.22271368
180Double outlet right ventricle (HP:0001719)1.22271368
181Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.21858941
182Asymmetric septal hypertrophy (HP:0001670)1.21308636
183J-shaped sella turcica (HP:0002680)1.20231344
184Easy fatigability (HP:0003388)1.16700449
185Nephropathy (HP:0000112)1.13896417
186Nephroblastoma (Wilms tumor) (HP:0002667)1.13883516
187Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.13566050
188Bundle branch block (HP:0011710)1.13358540
189Truncal obesity (HP:0001956)1.12299134
190Short humerus (HP:0005792)1.12287891
191Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.11927245
192Broad distal phalanx of finger (HP:0009836)1.11876363
193Flattened epiphyses (HP:0003071)1.10905736

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.99862002
2PDK47.99862002
3TESK16.18078922
4PRKD35.41495842
5PDK25.21995113
6LATS24.43243961
7ICK4.34195408
8LATS14.16526811
9DDR22.74684981
10TTN2.60264616
11IKBKE2.50200442
12STK162.30703661
13KDR2.25214771
14PTK2B2.24971228
15WNK42.16218135
16STK392.03446865
17BRD41.91088482
18STK381.85930742
19PNCK1.83480878
20PIK3CG1.64399784
21NEK21.63839139
22MAP3K111.61065964
23RPS6KA21.56289141
24DYRK1B1.53407410
25MYLK1.32974602
26TIE11.32845935
27MAP3K121.31322057
28KSR21.29527380
29ARAF1.24444484
30INSRR1.21606567
31TYRO31.20486942
32PLK21.18971959
33PDK11.12098911
34AKT31.11389742
35CDK121.09193242
36WNK11.08283320
37FES1.07310113
38CAMKK20.98705649
39MAP3K90.97229802
40CAMK2G0.95520132
41TRPM70.91876969
42EPHA40.91128796
43DYRK30.90508973
44TTK0.88530721
45BUB10.87806327
46CAMK2B0.81678842
47RPS6KL10.79535197
48RPS6KC10.79535197
49LIMK10.78959615
50RPS6KA60.78246142
51DMPK0.78186653
52MAPK150.76997473
53MST1R0.75138591
54CAMK2A0.74808790
55ROCK10.74238424
56PRKAA20.73160903
57DYRK1A0.72202534
58STK30.71454357
59PRKD20.71250735
60PAK60.69487804
61CHEK20.68453747
62NTRK30.68232095
63PASK0.67899062
64TAF10.66260615
65MOS0.64595610
66MAP2K60.63990149
67IRAK10.63458475
68CAMK1D0.63002433
69FRK0.62486621
70PDPK10.62408303
71TESK20.61355846
72MAP2K40.61216823
73CCNB10.59882793
74STK38L0.58458352
75BMPR1B0.56648776
76MET0.56105887
77CAMK10.54267349
78CAMK2D0.52475542
79GRK50.52417797
80EEF2K0.52237174
81PRKCH0.52118808
82MAP3K130.49690134
83CDK50.49657216
84CAMK1G0.48054277
85MAP3K30.47746529
86PINK10.47689766
87PTK20.47607093
88BRAF0.47583413
89RIPK40.46958527
90LMTK20.46635389
91CHEK10.46558764
92FER0.45773530
93MAP2K10.43548052
94PAK10.42362347
95MAP3K10.41379944
96PDGFRB0.41322050
97PRKD10.40065288
98MAPK10.39788763
99MARK20.38905348
100MAP3K100.38053487
101CSF1R0.37744098
102PAK40.35856289
103ADRBK10.35358359
104NTRK20.35256667
105STK100.35143310
106ACVR1B0.34605050
107MTOR0.32993522
108PRKCG0.32939087
109WEE10.31195550
110ATM0.30839378
111BMX0.30329757
112MUSK0.30068744
113PAK20.29540132
114IRAK20.29199832
115DAPK20.29188805
116PRKG20.27284682
117SGK10.26936707
118GSK3A0.26402523
119ERN10.26094743
120GRK10.26078142
121GRK60.25998745
122CAMK40.25557570
123ATR0.25258406
124PLK10.24868939
125PRKAA10.22264332
126PLK40.19878541
127ADRBK20.19818932
128BRSK20.19520336
129CDC70.18898239
130NEK60.17575247
131CAMKK10.16004631
132MAPKAPK50.14750577
133RPS6KB10.11935676
134CDK150.11607561
135PRKCZ0.10377024
136PRKCQ0.09976448
137CDK180.08717448
138CDK11A0.08123363
139GSK3B0.07756053
140TGFBR20.07735195
141MAPK70.07137364
142RIPK10.06915165
143CDK20.06643391
144PRKACG0.06439949
145MARK30.05257546
146BRSK10.05129860
147PRKCD0.04874272
148CSNK1D0.04840163
149CDK10.04622987
150TAOK10.04590499
151CSNK2A10.04161085
152RPS6KA10.03533399
153CDK140.03417133
154GRK70.02982474
155PRKG10.02891249
156CSK0.02766565
157AURKA0.02707278
158CDK40.02330597
159MAPK80.01622865
160EGFR0.01082697
161STK110.00772934
162ZAP700.00549777
163PRKCA-0.0156701
164WNK3-0.0134755
165PIM1-0.0126648
166CSNK2A2-0.0120118
167PRKACB-0.0111899
168CDK6-0.0084719

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.54773873
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.41866436
3Fatty acid biosynthesis_Homo sapiens_hsa000614.35085165
4Pyruvate metabolism_Homo sapiens_hsa006203.41342989
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.21326845
6Linoleic acid metabolism_Homo sapiens_hsa005913.12478467
7Propanoate metabolism_Homo sapiens_hsa006402.72577642
8Glucagon signaling pathway_Homo sapiens_hsa049222.50785510
9Basal transcription factors_Homo sapiens_hsa030222.39275282
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.35341635
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.19313776
12ECM-receptor interaction_Homo sapiens_hsa045122.17217136
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.08652988
14Selenocompound metabolism_Homo sapiens_hsa004502.07300129
15Nicotine addiction_Homo sapiens_hsa050332.06781852
16Fructose and mannose metabolism_Homo sapiens_hsa000512.05326265
17Glycerolipid metabolism_Homo sapiens_hsa005612.02413071
18Morphine addiction_Homo sapiens_hsa050322.02135345
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.94506043
20PPAR signaling pathway_Homo sapiens_hsa033201.94336782
21Pentose phosphate pathway_Homo sapiens_hsa000301.91106363
22Dopaminergic synapse_Homo sapiens_hsa047281.80957469
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.74672450
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.74361712
25Glycerophospholipid metabolism_Homo sapiens_hsa005641.70295914
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.67496996
27Dorso-ventral axis formation_Homo sapiens_hsa043201.64673795
28Oocyte meiosis_Homo sapiens_hsa041141.61806597
29Fanconi anemia pathway_Homo sapiens_hsa034601.55700466
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.55439099
31GABAergic synapse_Homo sapiens_hsa047271.49639743
32Ether lipid metabolism_Homo sapiens_hsa005651.44261583
33Focal adhesion_Homo sapiens_hsa045101.43049771
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.41601746
35Carbon metabolism_Homo sapiens_hsa012001.38531455
36Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.38469235
37Amphetamine addiction_Homo sapiens_hsa050311.34248045
38Cholinergic synapse_Homo sapiens_hsa047251.32951624
39Mineral absorption_Homo sapiens_hsa049781.32792077
40Fat digestion and absorption_Homo sapiens_hsa049751.30422004
41Fatty acid metabolism_Homo sapiens_hsa012121.28638491
42Fatty acid degradation_Homo sapiens_hsa000711.24933793
43Olfactory transduction_Homo sapiens_hsa047401.24156062
44Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.21121943
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.20061755
46Dilated cardiomyopathy_Homo sapiens_hsa054141.19229372
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18711140
48Cardiac muscle contraction_Homo sapiens_hsa042601.17967718
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.17696251
50Glutamatergic synapse_Homo sapiens_hsa047241.14405891
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14037301
52Aldosterone synthesis and secretion_Homo sapiens_hsa049251.13740517
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13465595
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.13155614
55Oxytocin signaling pathway_Homo sapiens_hsa049211.12214305
56Regulation of actin cytoskeleton_Homo sapiens_hsa048101.11903776
57mRNA surveillance pathway_Homo sapiens_hsa030151.11396777
58Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.11356573
59Serotonergic synapse_Homo sapiens_hsa047261.10168614
60Adherens junction_Homo sapiens_hsa045201.08393906
61Arachidonic acid metabolism_Homo sapiens_hsa005901.08392867
62RNA transport_Homo sapiens_hsa030131.05956291
63Renin secretion_Homo sapiens_hsa049241.04564021
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00887200
65Type II diabetes mellitus_Homo sapiens_hsa049301.00544174
66Huntingtons disease_Homo sapiens_hsa050160.98981490
67Phototransduction_Homo sapiens_hsa047440.97265707
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96372943
69Antigen processing and presentation_Homo sapiens_hsa046120.95637219
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95051787
71Purine metabolism_Homo sapiens_hsa002300.91622598
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91087512
73Chemical carcinogenesis_Homo sapiens_hsa052040.90582479
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89851954
75Hedgehog signaling pathway_Homo sapiens_hsa043400.89278367
76Glutathione metabolism_Homo sapiens_hsa004800.87021698
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86990443
78Biosynthesis of amino acids_Homo sapiens_hsa012300.86835629
79Malaria_Homo sapiens_hsa051440.86555328
80MAPK signaling pathway_Homo sapiens_hsa040100.84566034
81Gap junction_Homo sapiens_hsa045400.83165553
82Sphingolipid metabolism_Homo sapiens_hsa006000.81449959
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79396107
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.79189950
85Platelet activation_Homo sapiens_hsa046110.78812606
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75509218
87Renin-angiotensin system_Homo sapiens_hsa046140.73950651
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.73763292
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71208998
90Long-term depression_Homo sapiens_hsa047300.69014741
91Prolactin signaling pathway_Homo sapiens_hsa049170.68059954
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65808386
93Protein digestion and absorption_Homo sapiens_hsa049740.65195771
94Bile secretion_Homo sapiens_hsa049760.65066880
95Long-term potentiation_Homo sapiens_hsa047200.63667139
96Collecting duct acid secretion_Homo sapiens_hsa049660.63632702
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.63206505
98Tight junction_Homo sapiens_hsa045300.62920015
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.62172246
100T cell receptor signaling pathway_Homo sapiens_hsa046600.62071496
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61504190
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61302668
103GnRH signaling pathway_Homo sapiens_hsa049120.60239939
104Insulin secretion_Homo sapiens_hsa049110.60197762
105Rap1 signaling pathway_Homo sapiens_hsa040150.59030351
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58938084
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58282954
108Estrogen signaling pathway_Homo sapiens_hsa049150.58081200
109Amoebiasis_Homo sapiens_hsa051460.57825150
110Thyroid hormone synthesis_Homo sapiens_hsa049180.54746921
111ErbB signaling pathway_Homo sapiens_hsa040120.52763070
112AMPK signaling pathway_Homo sapiens_hsa041520.51829530
113Calcium signaling pathway_Homo sapiens_hsa040200.50411146
114Regulation of autophagy_Homo sapiens_hsa041400.49469469
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49403001
116Inositol phosphate metabolism_Homo sapiens_hsa005620.48270137
117ABC transporters_Homo sapiens_hsa020100.48073286
118Legionellosis_Homo sapiens_hsa051340.47746268
119Proteoglycans in cancer_Homo sapiens_hsa052050.47205263
120Ras signaling pathway_Homo sapiens_hsa040140.46624482
121Toll-like receptor signaling pathway_Homo sapiens_hsa046200.45892805
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45797780
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44385279
124Melanogenesis_Homo sapiens_hsa049160.43447997
125Insulin resistance_Homo sapiens_hsa049310.43423855
126Systemic lupus erythematosus_Homo sapiens_hsa053220.43254097
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42311960
128Salmonella infection_Homo sapiens_hsa051320.41748813
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41482153
130Endocytosis_Homo sapiens_hsa041440.40616093
131Renal cell carcinoma_Homo sapiens_hsa052110.40502291
132Axon guidance_Homo sapiens_hsa043600.39663347
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39049929
134Metabolic pathways_Homo sapiens_hsa011000.38395642
135Vascular smooth muscle contraction_Homo sapiens_hsa042700.38294965
136Taste transduction_Homo sapiens_hsa047420.38184280
137VEGF signaling pathway_Homo sapiens_hsa043700.37613188
138Salivary secretion_Homo sapiens_hsa049700.35251256
139Pancreatic secretion_Homo sapiens_hsa049720.32299763
140Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28983295
141cAMP signaling pathway_Homo sapiens_hsa040240.28930764
142Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28499906
143Sulfur metabolism_Homo sapiens_hsa009200.23483192
144Basal cell carcinoma_Homo sapiens_hsa052170.21834652
145Synaptic vesicle cycle_Homo sapiens_hsa047210.20333979
146Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.19036712
147Gastric acid secretion_Homo sapiens_hsa049710.18523656
148Pyrimidine metabolism_Homo sapiens_hsa002400.17312949
149Wnt signaling pathway_Homo sapiens_hsa043100.15799864
150Alcoholism_Homo sapiens_hsa050340.15532212
151Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.14634126
152RNA degradation_Homo sapiens_hsa030180.12971536
153N-Glycan biosynthesis_Homo sapiens_hsa005100.11507332
154Galactose metabolism_Homo sapiens_hsa000520.10850157
155Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.10455694
156Circadian entrainment_Homo sapiens_hsa047130.09976772
157Viral carcinogenesis_Homo sapiens_hsa052030.08483566
158Retinol metabolism_Homo sapiens_hsa008300.08229765
159Cocaine addiction_Homo sapiens_hsa050300.08147938

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