SLC22A15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Organic ion transporters, such as SLC22A15, transport various medically and physiologically important compounds, including pharmaceuticals, toxins, hormones, neurotransmitters, and cellular metabolites. These transporters are also referred to as amphiphilic solute facilitators (ASFs). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular extravasation (GO:0045123)5.72255997
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.50236870
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.50236870
4modulation by symbiont of host immune response (GO:0052553)5.50236870
5positive regulation by symbiont of host defense response (GO:0052509)5.50236870
6modulation by symbiont of host defense response (GO:0052031)5.50236870
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.50236870
8detection of molecule of bacterial origin (GO:0032490)5.46980443
9macrophage activation involved in immune response (GO:0002281)5.09054403
10microglial cell activation (GO:0001774)4.98004447
11positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.85129558
12positive regulation of gamma-delta T cell activation (GO:0046645)4.80095642
13myeloid leukocyte mediated immunity (GO:0002444)4.63185676
14positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.61374032
15superoxide anion generation (GO:0042554)4.46355035
16negative regulation of cell killing (GO:0031342)4.43187435
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.43187435
18macrophage activation (GO:0042116)4.39926082
19regulation of interferon-beta biosynthetic process (GO:0045357)3.99402647
20negative regulation of interleukin-12 production (GO:0032695)3.97258409
21detection of biotic stimulus (GO:0009595)3.92175006
22positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.82645090
23leukocyte migration involved in inflammatory response (GO:0002523)3.80491161
24negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.70647370
25respiratory burst (GO:0045730)3.61960605
26response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.61489432
27response to host (GO:0075136)3.61489432
28response to host defenses (GO:0052200)3.61489432
29myeloid cell activation involved in immune response (GO:0002275)3.60365184
30multicellular organism reproduction (GO:0032504)3.57852786
31negative regulation of lymphocyte mediated immunity (GO:0002707)3.57569127
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.55435458
33regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.49741665
34regulation of mast cell degranulation (GO:0043304)3.47122506
35positive regulation of mast cell activation (GO:0033005)3.43030446
36leukocyte aggregation (GO:0070486)3.32868822
37negative regulation of erythrocyte differentiation (GO:0045647)3.30614895
38acrosome reaction (GO:0007340)3.29584709
39regulation of myeloid leukocyte mediated immunity (GO:0002886)3.27370782
40regulation of mast cell activation involved in immune response (GO:0033006)3.27041948
41regulation of gamma-delta T cell activation (GO:0046643)3.26175318
42production of molecular mediator involved in inflammatory response (GO:0002532)3.25175773
43regulation of leukocyte degranulation (GO:0043300)3.24070811
44positive regulation of cellular amide metabolic process (GO:0034250)3.23927112
45negative regulation of interleukin-17 production (GO:0032700)3.17165953
46positive regulation of mast cell degranulation (GO:0043306)3.16180367
47positive regulation of mast cell activation involved in immune response (GO:0033008)3.16180367
48cilium or flagellum-dependent cell motility (GO:0001539)3.15668015
49detection of other organism (GO:0098543)3.14789941
50response to peptidoglycan (GO:0032494)3.14558078
51regulation of regulated secretory pathway (GO:1903305)3.13842937
52regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.10678586
53positive regulation of toll-like receptor signaling pathway (GO:0034123)3.06689705
54mesenchymal cell differentiation involved in renal system development (GO:2001012)3.06304081
55mesenchymal cell differentiation involved in kidney development (GO:0072161)3.06304081
56dendritic cell chemotaxis (GO:0002407)3.04300809
57T-helper cell differentiation (GO:0042093)3.03506259
58CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.03506259
59activated T cell proliferation (GO:0050798)3.01523291
60negative regulation of leukocyte mediated immunity (GO:0002704)3.01273833
61regulation of macrophage cytokine production (GO:0010935)3.00898280
62regulation of interleukin-8 biosynthetic process (GO:0045414)3.00353624
63detection of bacterium (GO:0016045)2.98781157
64daunorubicin metabolic process (GO:0044597)2.98683706
65polyketide metabolic process (GO:0030638)2.98683706
66doxorubicin metabolic process (GO:0044598)2.98683706
67neutrophil activation (GO:0042119)2.98410261
68killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.95084927
69disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.95084927
70lipopolysaccharide-mediated signaling pathway (GO:0031663)2.90320143
71B cell receptor signaling pathway (GO:0050853)2.89704164
72positive regulation of regulated secretory pathway (GO:1903307)2.89493115
73positive regulation of macrophage cytokine production (GO:0060907)2.87025942
74G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.85154586
75energy homeostasis (GO:0097009)2.84848077
76positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.82757256
77negative regulation of mast cell activation (GO:0033004)2.82581309
78regulation of interleukin-8 secretion (GO:2000482)2.82283662
79cellular response to interleukin-15 (GO:0071350)2.81473526
80hypotonic response (GO:0006971)2.80937169
81axonemal dynein complex assembly (GO:0070286)2.79260293
82presynaptic membrane assembly (GO:0097105)2.76669114
83regulation of T-helper 2 cell differentiation (GO:0045628)2.76102079
84positive regulation of leukocyte degranulation (GO:0043302)2.75882316
85G-protein coupled receptor internalization (GO:0002031)2.74457557
86regulation of interleukin-6 biosynthetic process (GO:0045408)2.74112924
87negative regulation of growth of symbiont in host (GO:0044130)2.73918283
88negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.73918283
89modulation of growth of symbiont involved in interaction with host (GO:0044144)2.73918283
90regulation of growth of symbiont in host (GO:0044126)2.73918283
91CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.73318068
92leukocyte degranulation (GO:0043299)2.72701204
93dendritic cell migration (GO:0036336)2.72267010
94neutrophil chemotaxis (GO:0030593)2.71099126
95sperm motility (GO:0030317)2.68495826
96positive regulation of T cell mediated cytotoxicity (GO:0001916)2.67745872
97regulation of beta-amyloid formation (GO:1902003)2.67128214
98negative regulation of interleukin-8 production (GO:0032717)2.66389194
99negative regulation of toll-like receptor signaling pathway (GO:0034122)2.66076397
100antigen processing and presentation of endogenous antigen (GO:0019883)2.65948774
101negative regulation of immunoglobulin mediated immune response (GO:0002890)2.65900478
102negative regulation of B cell mediated immunity (GO:0002713)2.65900478
103myeloid leukocyte activation (GO:0002274)2.65539413
104eosinophil migration (GO:0072677)2.65353768
105regulation of toll-like receptor signaling pathway (GO:0034121)2.64983825
106regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.64728548
107neutrophil migration (GO:1990266)2.64457881
108protein K11-linked deubiquitination (GO:0035871)2.64062983
109negative regulation of interleukin-6 production (GO:0032715)2.64058828
110I-kappaB phosphorylation (GO:0007252)2.63177892
111startle response (GO:0001964)2.62523513
112regulation of hypersensitivity (GO:0002883)2.61970913
113negative regulation of type 2 immune response (GO:0002829)2.61939457
114regulation of gamma-delta T cell differentiation (GO:0045586)2.60647647
115nucleotide transmembrane transport (GO:1901679)2.59617539
116positive regulation of B cell differentiation (GO:0045579)2.57583334
117alpha-beta T cell differentiation involved in immune response (GO:0002293)2.56314469
118alpha-beta T cell activation involved in immune response (GO:0002287)2.56314469
119T cell differentiation involved in immune response (GO:0002292)2.56314469
120regulation of activation of Janus kinase activity (GO:0010533)2.56023471
121regulation of cellular amide metabolic process (GO:0034248)2.55562935
122defense response to protozoan (GO:0042832)2.55276734
123epithelial cilium movement (GO:0003351)2.54163455
124positive regulation of lymphocyte migration (GO:2000403)2.54136456
125negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.53592928
126presynaptic membrane organization (GO:0097090)2.53500243
127cornea development in camera-type eye (GO:0061303)2.51119304
128granulocyte activation (GO:0036230)2.50996498
129neutrophil activation involved in immune response (GO:0002283)2.50430976
130eosinophil chemotaxis (GO:0048245)2.50305681
131positive regulation of T cell migration (GO:2000406)2.46891177
132reproduction (GO:0000003)2.46597957
133glucosamine-containing compound catabolic process (GO:1901072)2.46437516
134negative regulation of keratinocyte proliferation (GO:0010839)2.46375648
135interferon-gamma production (GO:0032609)2.46167210
136centriole assembly (GO:0098534)2.45245620
137motile cilium assembly (GO:0044458)2.44067067
138negative regulation of T cell mediated immunity (GO:0002710)2.42045893
139developmental pigmentation (GO:0048066)2.41838963
140purinergic nucleotide receptor signaling pathway (GO:0035590)2.38393743
141CD4-positive, alpha-beta T cell activation (GO:0035710)2.38298489
142regulation of dendritic cell antigen processing and presentation (GO:0002604)2.37836272
143monocyte chemotaxis (GO:0002548)2.37580228
144microtubule depolymerization (GO:0007019)2.36315484
145amine catabolic process (GO:0009310)2.33818712
146cellular biogenic amine catabolic process (GO:0042402)2.33818712
147adenosine metabolic process (GO:0046085)2.32182665
148neutrophil mediated immunity (GO:0002446)2.32119958
149T cell activation involved in immune response (GO:0002286)2.31481311
150positive regulation of interleukin-1 beta secretion (GO:0050718)2.29379156
151regulation of mast cell activation (GO:0033003)2.28842364
152positive regulation of T-helper 1 type immune response (GO:0002827)2.28615358
153regulation of germinal center formation (GO:0002634)2.28007071
154cilium movement (GO:0003341)2.27620227
155regulation of cellular extravasation (GO:0002691)2.25870773
156regulation of lymphocyte chemotaxis (GO:1901623)2.25738325
157NAD biosynthetic process (GO:0009435)2.25710075
158dentate gyrus development (GO:0021542)2.25221769
159cellular response to type I interferon (GO:0071357)2.23694998
160type I interferon signaling pathway (GO:0060337)2.23694998
161sympathetic nervous system development (GO:0048485)2.23228669
162response to host immune response (GO:0052572)2.23067912
163response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.23067912
164superoxide metabolic process (GO:0006801)2.22672334
165ceramide catabolic process (GO:0046514)2.22284434
166regulation of B cell receptor signaling pathway (GO:0050855)2.22256838
167regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.21537952
168response to type I interferon (GO:0034340)2.21288074
169detection of external biotic stimulus (GO:0098581)2.21161018
170limb bud formation (GO:0060174)2.20975682
171regulation of T cell chemotaxis (GO:0010819)2.20200567
172positive regulation of T cell chemotaxis (GO:0010820)2.20200567
173regulation of interleukin-1 beta secretion (GO:0050706)2.19796353
174opioid receptor signaling pathway (GO:0038003)2.19453520
175regulation of antigen processing and presentation (GO:0002577)2.17567581
176myeloid dendritic cell activation (GO:0001773)2.17361732
177cell wall macromolecule catabolic process (GO:0016998)2.17135553
178cell wall macromolecule metabolic process (GO:0044036)2.17135553
179positive regulation of antigen processing and presentation (GO:0002579)2.16501677
180extracellular negative regulation of signal transduction (GO:1900116)2.16285494
181extracellular regulation of signal transduction (GO:1900115)2.16285494
182positive regulation of uterine smooth muscle contraction (GO:0070474)2.16273082
183response to muramyl dipeptide (GO:0032495)2.15994966

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.50693327
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.48203918
3SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.13932296
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.99830699
5* GBX2_23144817_ChIP-Seq_PC3_Human2.98493251
6MYB_21317192_ChIP-Seq_ERMYB_Mouse2.95280388
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.74861454
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.61827284
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.52806900
10* VDR_24763502_ChIP-Seq_THP-1_Human2.52723023
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.52592769
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.48249537
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.34678094
14VDR_24787735_ChIP-Seq_THP-1_Human2.30315613
15EZH2_22144423_ChIP-Seq_EOC_Human2.27195187
16SUZ12_27294783_Chip-Seq_NPCs_Mouse2.21339739
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20062989
18NFE2_27457419_Chip-Seq_LIVER_Mouse2.14117617
19RUNX_20019798_ChIP-Seq_JUKART_Human2.13790452
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.08787227
21IRF8_22096565_ChIP-ChIP_GC-B_Human2.07377518
22* VDR_21846776_ChIP-Seq_THP-1_Human2.06995900
23SPI1_23127762_ChIP-Seq_K562_Human2.05377584
24TAF15_26573619_Chip-Seq_HEK293_Human2.04188988
25PCGF2_27294783_Chip-Seq_NPCs_Mouse1.99761606
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.96190175
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.94563345
28SCL_19346495_ChIP-Seq_HPC-7_Human1.93998656
29* SPI1_23547873_ChIP-Seq_NB4_Human1.85123932
30EZH2_27294783_Chip-Seq_NPCs_Mouse1.84340402
31EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.83537110
32NANOG_18555785_Chip-Seq_ESCs_Mouse1.80172772
33TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.79938003
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.79784599
35P53_22387025_ChIP-Seq_ESCs_Mouse1.77182938
36SUZ12_18555785_Chip-Seq_ESCs_Mouse1.76990283
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.76662184
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74825302
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.72717516
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.72346267
41* STAT3_18555785_Chip-Seq_ESCs_Mouse1.70700188
42* E2F1_18555785_Chip-Seq_ESCs_Mouse1.70601448
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.68055884
44P300_19829295_ChIP-Seq_ESCs_Human1.66982762
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65380910
46EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.65116236
47* NMYC_18555785_Chip-Seq_ESCs_Mouse1.64418707
48CMYC_18555785_Chip-Seq_ESCs_Mouse1.64166706
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60782283
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.60509985
51* P300_18555785_Chip-Seq_ESCs_Mouse1.57421869
52RUNX1_27457419_Chip-Seq_LIVER_Mouse1.56722473
53IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.56347940
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55972756
55OCT4_18555785_Chip-Seq_ESCs_Mouse1.55862201
56STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.54577396
57STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53496297
58SOX2_18555785_Chip-Seq_ESCs_Mouse1.51963844
59STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.51950900
60VDR_22108803_ChIP-Seq_LS180_Human1.51791657
61* PU1_27457419_Chip-Seq_LIVER_Mouse1.51266508
62ZFX_18555785_Chip-Seq_ESCs_Mouse1.47614093
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.47447296
64* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.45690952
65KLF4_18555785_Chip-Seq_ESCs_Mouse1.44268992
66EGR1_19374776_ChIP-ChIP_THP-1_Human1.42061750
67IGF1R_20145208_ChIP-Seq_DFB_Human1.40665535
68SMAD1_18555785_Chip-Seq_ESCs_Mouse1.40234862
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40179057
70KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40084671
71RUNX1_22412390_ChIP-Seq_EML_Mouse1.39642501
72MYB_26560356_Chip-Seq_TH2_Human1.38800542
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.38773283
74SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38560301
75SMAD4_21799915_ChIP-Seq_A2780_Human1.38225685
76CTCF_18555785_Chip-Seq_ESCs_Mouse1.36966504
77RNF2_27304074_Chip-Seq_NSC_Mouse1.36234328
78EED_16625203_ChIP-ChIP_MESCs_Mouse1.36158940
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36017444
80GATA1_19941827_ChIP-Seq_MEL_Mouse1.35597697
81GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35347814
82TCF7_22412390_ChIP-Seq_EML_Mouse1.34620336
83* ER_23166858_ChIP-Seq_MCF-7_Human1.34321895
84TAL1_26923725_Chip-Seq_HPCs_Mouse1.34040807
85PU_27001747_Chip-Seq_BMDM_Mouse1.33794961
86SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.32385720
87SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.32364267
88JARID2_20064375_ChIP-Seq_MESCs_Mouse1.31944428
89CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31610687
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.31358483
91Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.28743521
92OCT4_21477851_ChIP-Seq_ESCs_Mouse1.28689645
93SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.27472733
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26709180
95RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.25503476
96TP53_18474530_ChIP-ChIP_U2OS_Human1.24976912
97CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24432170
98IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24218883
99CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24169869
100E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23465732
101KDM2B_26808549_Chip-Seq_REH_Human1.22157288
102* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21464911
103VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21254214
104MAF_26560356_Chip-Seq_TH1_Human1.20374755
105EZH2_27304074_Chip-Seq_ESCs_Mouse1.19798256
106SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.18866458
107KDM2B_26808549_Chip-Seq_DND41_Human1.18249679
108TP53_16413492_ChIP-PET_HCT116_Human1.17981286
109DROSHA_22980978_ChIP-Seq_HELA_Human1.15645109
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12721836
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12721836
112* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12559264
113TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11626600
114MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11545070
115EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11386606
116CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10338473
117PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10258803
118LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09755598
119NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09662487
120MYB_26560356_Chip-Seq_TH1_Human1.09587144
121SMAD3_21741376_ChIP-Seq_EPCs_Human1.09141587
122IRF8_27001747_Chip-Seq_BMDM_Mouse1.09063191
123UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08789356
124CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08548911
125SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.08462014
126GATA2_21666600_ChIP-Seq_HMVEC_Human1.07743026
127FUS_26573619_Chip-Seq_HEK293_Human1.07282261
128EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06609320
129GATA3_27048872_Chip-Seq_THYMUS_Human1.06256859
130AR_25329375_ChIP-Seq_VCAP_Human1.06252448
131AR_21572438_ChIP-Seq_LNCaP_Human1.05615852
132SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03567452
133* STAT3_23295773_ChIP-Seq_U87_Human1.02687098
134TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02644572
135KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02022191
136* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01837680
137GATA2_19941826_ChIP-Seq_K562_Human1.01760741
138PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01676006
139PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01311082
140* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01073697
141RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00652162
142GATA1_22025678_ChIP-Seq_K562_Human1.00435787
143RUNX2_22187159_ChIP-Seq_PCA_Human1.00202758
144GATA1_19941826_ChIP-Seq_K562_Human0.99817884
145RNF2_27304074_Chip-Seq_ESCs_Mouse0.99723206
146JARID2_20075857_ChIP-Seq_MESCs_Mouse0.99698507
147KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98737360
148* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.98586464
149KDM2B_26808549_Chip-Seq_JURKAT_Human0.98278231
150THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98191458
151KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.95325382
152RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95045793
153STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94873135
154* KDM2B_26808549_Chip-Seq_K562_Human0.90071463
155UTX_26944678_Chip-Seq_JUKART_Human0.89714398
156LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.89677091
157SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.87955097
158REST_21632747_ChIP-Seq_MESCs_Mouse0.86344215
159SMRT_27268052_Chip-Seq_Bcells_Human0.86176854
160* TP63_23658742_ChIP-Seq_EP156T_Human0.85389122
161RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.85352410
162TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84538809
163ESR1_20079471_ChIP-ChIP_T-47D_Human0.83870318
164GATA3_26560356_Chip-Seq_TH2_Human0.81688793
165RARB_27405468_Chip-Seq_BRAIN_Mouse0.81539785
166* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80426257
167GATA2_22383799_ChIP-Seq_G1ME_Mouse0.79686725
168* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79430588
169CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78711498
170FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.75700874
171* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.74856807
172FOXO3_23340844_ChIP-Seq_DLD1_Human0.74830646
173NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.72933566
174NRF2_20460467_ChIP-Seq_MEFs_Mouse0.72933566
175AHR_22903824_ChIP-Seq_MCF-7_Human0.70540867

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.42462873
2MP0003172_abnormal_lysosome_physiology3.41861436
3MP0001188_hyperpigmentation3.23973026
4MP0004381_abnormal_hair_follicle3.08980343
5MP0005645_abnormal_hypothalamus_physiol3.06010761
6MP0001835_abnormal_antigen_presentation2.91639693
7MP0003724_increased_susceptibility_to2.86190811
8MP0003191_abnormal_cellular_cholesterol2.84861383
9MP0002277_abnormal_respiratory_mucosa2.50403027
10MP0000566_synostosis2.44761616
11MP0005409_darkened_coat_color2.44157449
12MP0003828_pulmonary_edema2.42899304
13MP0002148_abnormal_hypersensitivity_rea2.38345944
14MP0003690_abnormal_glial_cell2.33776942
15MP0006292_abnormal_olfactory_placode2.30827847
16MP0009785_altered_susceptibility_to2.26866928
17MP0001986_abnormal_taste_sensitivity2.23820937
18MP0005671_abnormal_response_to2.20150157
19MP0002876_abnormal_thyroid_physiology2.13004100
20MP0003941_abnormal_skin_development2.06702518
21MP0005387_immune_system_phenotype2.02193187
22MP0001790_abnormal_immune_system2.02193187
23MP0000015_abnormal_ear_pigmentation1.99614367
24MP0005410_abnormal_fertilization1.96300632
25MP0005075_abnormal_melanosome_morpholog1.93201428
26MP0002132_abnormal_respiratory_system1.89184124
27MP0003436_decreased_susceptibility_to1.88421366
28MP0003300_gastrointestinal_ulcer1.86263778
29MP0002138_abnormal_hepatobiliary_system1.82703669
30MP0005058_abnormal_lysosome_morphology1.80876864
31MP0009697_abnormal_copulation1.79346469
32MP0003136_yellow_coat_color1.74849159
33MP0002419_abnormal_innate_immunity1.74345720
34MP0000604_amyloidosis1.74335587
35MP0005423_abnormal_somatic_nervous1.74136841
36MP0003329_amyloid_beta_deposits1.71819873
37MP0004883_abnormal_blood_vessel1.66942871
38MP0005171_absent_coat_pigmentation1.64702303
39MP0003656_abnormal_erythrocyte_physiolo1.63606043
40MP0009278_abnormal_bone_marrow1.62266894
41MP0005000_abnormal_immune_tolerance1.60668288
42MP0005025_abnormal_response_to1.59348874
43MP0000372_irregular_coat_pigmentation1.58418457
44MP0001984_abnormal_olfaction1.58370549
45MP0009764_decreased_sensitivity_to1.54599777
46MP0005174_abnormal_tail_pigmentation1.52327120
47MP0001545_abnormal_hematopoietic_system1.51603824
48MP0005397_hematopoietic_system_phenotyp1.51603824
49MP0003075_altered_response_to1.50457254
50MP0005164_abnormal_response_to1.49090636
51MP0001800_abnormal_humoral_immune1.48808726
52MP0005646_abnormal_pituitary_gland1.48573156
53MP0000920_abnormal_myelination1.48378807
54MP0001346_abnormal_lacrimal_gland1.48365130
55MP0003763_abnormal_thymus_physiology1.43387879
56MP0002254_reproductive_system_inflammat1.43233106
57MP0002723_abnormal_immune_serum1.42578976
58MP0002009_preneoplasia1.42256835
59MP0002452_abnormal_antigen_presenting1.40334747
60MP0001851_eye_inflammation1.39136440
61MP0002420_abnormal_adaptive_immunity1.34465874
62MP0001819_abnormal_immune_cell1.34295014
63MP0000516_abnormal_urinary_system1.33868504
64MP0005367_renal/urinary_system_phenotyp1.33868504
65MP0002163_abnormal_gland_morphology1.33108142
66MP0000685_abnormal_immune_system1.31882393
67MP0001873_stomach_inflammation1.31072450
68MP0002102_abnormal_ear_morphology1.29560940
69MP0006276_abnormal_autonomic_nervous1.29272300
70MP0004782_abnormal_surfactant_physiolog1.28953102
71MP0002095_abnormal_skin_pigmentation1.28520390
72MP0004947_skin_inflammation1.26300494
73MP0000569_abnormal_digit_pigmentation1.26199565
74MP0005379_endocrine/exocrine_gland_phen1.25579569
75MP0002735_abnormal_chemical_nociception1.24128537
76MP0005451_abnormal_body_composition1.23745947
77MP0002396_abnormal_hematopoietic_system1.14425067
78MP0002933_joint_inflammation1.13792919
79MP0000465_gastrointestinal_hemorrhage1.10502675
80MP0004510_myositis1.07280699
81MP0003183_abnormal_peptide_metabolism1.06120047
82MP0003787_abnormal_imprinting1.05808708
83MP0010386_abnormal_urinary_bladder1.05770477
84MP0004130_abnormal_muscle_cell1.05203436
85MP0008874_decreased_physiological_sensi1.05022465
86MP0000579_abnormal_nail_morphology1.04777777
87MP0002405_respiratory_system_inflammati1.03673299
88MP0002722_abnormal_immune_system1.01186918
89MP0000689_abnormal_spleen_morphology1.01118779
90MP0004484_altered_response_of1.00980075
91MP0009046_muscle_twitch0.99811121
92MP0002006_tumorigenesis0.99345509
93MP0008789_abnormal_olfactory_epithelium0.98819918
94MP0000681_abnormal_thyroid_gland0.98615552
95MP0002166_altered_tumor_susceptibility0.97598961
96MP0008469_abnormal_protein_level0.97397891
97MP0002332_abnormal_exercise_endurance0.96059347
98MP0004742_abnormal_vestibular_system0.94931285
99MP0004859_abnormal_synaptic_plasticity0.93305201
100MP0010155_abnormal_intestine_physiology0.92970574
101MP0002429_abnormal_blood_cell0.92704528
102MP0009379_abnormal_foot_pigmentation0.91771444
103MP0001486_abnormal_startle_reflex0.89849796
104MP0005464_abnormal_platelet_physiology0.89536940
105MP0005076_abnormal_cell_differentiation0.89366589
106MP0006082_CNS_inflammation0.89303399
107MP0003221_abnormal_cardiomyocyte_apopto0.88377998
108MP0003635_abnormal_synaptic_transmissio0.88297203
109MP0000858_altered_metastatic_potential0.88154579
110MP0005166_decreased_susceptibility_to0.88154534
111MP0001440_abnormal_grooming_behavior0.87991266
112MP0000678_abnormal_parathyroid_gland0.87763451
113MP0004270_analgesia0.87616488
114MP0001533_abnormal_skeleton_physiology0.87464309
115MP0002998_abnormal_bone_remodeling0.86569824
116MP0002638_abnormal_pupillary_reflex0.86365173
117MP0001845_abnormal_inflammatory_respons0.85851422
118MP0001186_pigmentation_phenotype0.85847562
119MP0000716_abnormal_immune_system0.85618731
120MP0002736_abnormal_nociception_after0.85507027
121MP0005310_abnormal_salivary_gland0.84778161
122MP0002098_abnormal_vibrissa_morphology0.84746079
123MP0002064_seizures0.84521162
124MP0003866_abnormal_defecation0.84373292
125MP0000538_abnormal_urinary_bladder0.83702949
126MP0003879_abnormal_hair_cell0.83433785
127MP0003633_abnormal_nervous_system0.83344742
128MP0003632_abnormal_nervous_system0.82551555
129MP0004808_abnormal_hematopoietic_stem0.82239345
130MP0003045_fibrosis0.81771637
131MP0002938_white_spotting0.80789774
132MP0005388_respiratory_system_phenotype0.80645095
133MP0002133_abnormal_respiratory_system0.80645095
134MP0001853_heart_inflammation0.79579613
135MP0008995_early_reproductive_senescence0.79054323
136MP0008260_abnormal_autophagy0.77314919
137MP0001502_abnormal_circadian_rhythm0.76201002
138MP0001501_abnormal_sleep_pattern0.75238621
139MP0003091_abnormal_cell_migration0.74177650
140MP0003880_abnormal_central_pattern0.74108044
141MP0003448_altered_tumor_morphology0.73661642
142MP0000026_abnormal_inner_ear0.71740524
143MP0003631_nervous_system_phenotype0.71679341
144MP0005647_abnormal_sex_gland0.71230766
145MP0008004_abnormal_stomach_pH0.69479183
146MP0001968_abnormal_touch/_nociception0.69108076
147MP0002398_abnormal_bone_marrow0.68742618
148MP0005499_abnormal_olfactory_system0.68598606
149MP0005394_taste/olfaction_phenotype0.68598606
150MP0008877_abnormal_DNA_methylation0.65978581
151MP0009745_abnormal_behavioral_response0.64138784
152MP0005535_abnormal_body_temperature0.63234357
153MP0002063_abnormal_learning/memory/cond0.62833589

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macrophages (HP:0004311)4.61201863
2Dynein arm defect of respiratory motile cilia (HP:0012255)4.21526452
3Absent/shortened dynein arms (HP:0200106)4.21526452
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.15023830
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.65499793
6Elevated erythrocyte sedimentation rate (HP:0003565)3.39642570
7Retrobulbar optic neuritis (HP:0100654)3.34228943
8Optic neuritis (HP:0100653)3.34228943
9Gastrointestinal infarctions (HP:0005244)3.24845158
10Renal cortical cysts (HP:0000803)3.24605616
11Recurrent abscess formation (HP:0002722)3.23920532
12Amyloidosis (HP:0011034)3.21736925
13Aplasia cutis congenita (HP:0001057)3.17566971
14Abnormality of liposaccharide metabolism (HP:0010968)3.17528212
15Abnormality of glycosphingolipid metabolism (HP:0004343)3.17528212
16Abnormality of glycolipid metabolism (HP:0010969)3.17528212
17Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.16107082
18Chromsome breakage (HP:0040012)3.09280290
19Tubulointerstitial nephritis (HP:0001970)3.02767583
20Supranuclear gaze palsy (HP:0000605)2.97461919
21Abnormal ciliary motility (HP:0012262)2.93762560
22Eczematoid dermatitis (HP:0000976)2.93638829
23Abnormal respiratory motile cilium physiology (HP:0012261)2.89624762
24Slow saccadic eye movements (HP:0000514)2.87654513
25Abnormal respiratory motile cilium morphology (HP:0005938)2.86214097
26Abnormal respiratory epithelium morphology (HP:0012253)2.86214097
27Recurrent bacterial skin infections (HP:0005406)2.84625439
28Recurrent cutaneous fungal infections (HP:0011370)2.81407876
29Chronic mucocutaneous candidiasis (HP:0002728)2.81407876
30Urticaria (HP:0001025)2.80369011
31Alveolar cell carcinoma (HP:0006519)2.72392493
32Myositis (HP:0100614)2.72024871
33Spontaneous hematomas (HP:0007420)2.70868799
34Prostate neoplasm (HP:0100787)2.69487102
35Parakeratosis (HP:0001036)2.67074165
36Orchitis (HP:0100796)2.65208213
37Hemoptysis (HP:0002105)2.64524860
38Peritonitis (HP:0002586)2.63219917
39Joint hemorrhage (HP:0005261)2.63218166
40Chest pain (HP:0100749)2.62493492
41Increased cerebral lipofuscin (HP:0011813)2.60706771
42Papilledema (HP:0001085)2.59272018
43Chronic hepatic failure (HP:0100626)2.58531091
44White forelock (HP:0002211)2.58255936
45Hypothermia (HP:0002045)2.58241297
46Increased IgM level (HP:0003496)2.58187513
47Episodic fever (HP:0001954)2.55164011
48Neurofibrillary tangles (HP:0002185)2.54710831
49Abnormal delayed hypersensitivity skin test (HP:0002963)2.54198889
50Patchy hypopigmentation of hair (HP:0011365)2.51674225
51Cellulitis (HP:0100658)2.51147813
52Pulmonary embolism (HP:0002204)2.50484584
53Abnormality of the renal cortex (HP:0011035)2.49493593
54Febrile seizures (HP:0002373)2.46971126
55Dry hair (HP:0011359)2.41815362
56Chronic diarrhea (HP:0002028)2.41402132
57Abnormality of incisor morphology (HP:0011063)2.40544953
58Abnormal hair whorl (HP:0010721)2.36445132
59Hypochromic microcytic anemia (HP:0004840)2.34572096
60True hermaphroditism (HP:0010459)2.34432200
61Osteomalacia (HP:0002749)2.34190450
62Abnormality of the renal medulla (HP:0100957)2.32172194
63Pulmonary infiltrates (HP:0002113)2.30521415
64Disinhibition (HP:0000734)2.29734091
65Thrombocytosis (HP:0001894)2.29248177
66Duplicated collecting system (HP:0000081)2.29097234
67Recurrent skin infections (HP:0001581)2.28069887
68Gingivitis (HP:0000230)2.27570750
69Abnormality of the renal collecting system (HP:0004742)2.24597525
70Chronic obstructive pulmonary disease (HP:0006510)2.23692899
71Obstructive lung disease (HP:0006536)2.23692899
72Nephronophthisis (HP:0000090)2.23294448
73Congenital sensorineural hearing impairment (HP:0008527)2.23076085
74Postural instability (HP:0002172)2.22621924
75Epistaxis (HP:0000421)2.21757128
76Stomatitis (HP:0010280)2.20445114
77Difficulty running (HP:0009046)2.19431711
78Recurrent fungal infections (HP:0002841)2.19189323
79Dysostosis multiplex (HP:0000943)2.17958677
80Submucous cleft hard palate (HP:0000176)2.17812245
81Clubbing of toes (HP:0100760)2.17172368
82Recurrent pneumonia (HP:0006532)2.14818282
83Conjugated hyperbilirubinemia (HP:0002908)2.14289948
84Prolonged partial thromboplastin time (HP:0003645)2.14084899
85Loss of speech (HP:0002371)2.12878152
86Neoplasm of the tracheobronchial system (HP:0100552)2.12820154
87Increased neuronal autofluorescent lipopigment (HP:0002074)2.12264802
88Meningitis (HP:0001287)2.11622586
89Fair hair (HP:0002286)2.11117891
90Osteomyelitis (HP:0002754)2.09796751
91Ankle clonus (HP:0011448)2.09555082
92Diplopia (HP:0000651)2.08099761
93Abnormality of binocular vision (HP:0011514)2.08099761
94Recurrent gram-negative bacterial infections (HP:0005420)2.08059286
95Cerebral inclusion bodies (HP:0100314)2.08004561
96Absent eyebrow (HP:0002223)2.06808726
97Vertigo (HP:0002321)2.04267829
98Congenital hepatic fibrosis (HP:0002612)2.04139177
99Abnormality of the nasal septum (HP:0000419)2.03906738
100Neuronal loss in central nervous system (HP:0002529)2.03313371
101Mediastinal lymphadenopathy (HP:0100721)2.02404630
102Medial flaring of the eyebrow (HP:0010747)2.00983267
103Decreased central vision (HP:0007663)2.00145937
104Degeneration of the lateral corticospinal tracts (HP:0002314)1.99685764
105Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.99685764
106Abnormality of DNA repair (HP:0003254)1.99519626
107Abnormality of the prostate (HP:0008775)1.99488079
108Leukocytosis (HP:0001974)1.98778998
109Scanning speech (HP:0002168)1.98202981
110Recurrent sinusitis (HP:0011108)1.96686012
111Pancreatic fibrosis (HP:0100732)1.96474111
112Lip pit (HP:0100267)1.96111005
113Gangrene (HP:0100758)1.95966854
114Keratoconjunctivitis (HP:0001096)1.94682447
115Hip dysplasia (HP:0001385)1.94458523
116Ocular albinism (HP:0001107)1.93337988
117Increased IgE level (HP:0003212)1.93310355
118Keratitis (HP:0000491)1.92787585
119Ectropion (HP:0000656)1.92287909
120Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.91767323
121Generalized hypopigmentation of hair (HP:0011358)1.91603200
122Hypochromic anemia (HP:0001931)1.91380244
123Cheilitis (HP:0100825)1.91240549
124Gingival bleeding (HP:0000225)1.91024098
125Rhinitis (HP:0012384)1.90472962
126Encephalitis (HP:0002383)1.89065720
127Vasculitis (HP:0002633)1.88997157
128Interstitial pulmonary disease (HP:0006530)1.88690051
129Keratoconjunctivitis sicca (HP:0001097)1.88099344
130Abnormality of the endocardium (HP:0004306)1.88007953
131T lymphocytopenia (HP:0005403)1.87761679
132Sepsis (HP:0100806)1.87748426
133Papillary thyroid carcinoma (HP:0002895)1.86733286
134Action tremor (HP:0002345)1.85872704
135Anorexia (HP:0002039)1.85494834
136Menstrual irregularities (HP:0000858)1.85134983
137Spastic gait (HP:0002064)1.85043286
138Abnormality of the corticospinal tract (HP:0002492)1.84873952
139Skin ulcer (HP:0200042)1.82698567
140Hypoplasia of the fovea (HP:0007750)1.80516728
141Aplasia/Hypoplasia of the fovea (HP:0008060)1.80516728
142Anhidrosis (HP:0000970)1.80464845
143Agitation (HP:0000713)1.79433156
144Stomach cancer (HP:0012126)1.79346674
145Lower limb muscle weakness (HP:0007340)1.78793418
146Resting tremor (HP:0002322)1.77936227
147Conical tooth (HP:0000698)1.77695109
148Median cleft lip (HP:0000161)1.76931501
149Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.76733695
150Apathy (HP:0000741)1.76450175
151Global brain atrophy (HP:0002283)1.75310707
152Abnormality of T cell number (HP:0011839)1.75263058
153Visual hallucinations (HP:0002367)1.75072317
154Diminished motivation (HP:0000745)1.74826403
155Tubulointerstitial abnormality (HP:0001969)1.74785763
156Thick nail (HP:0001805)1.74701981
157Inflammation of the large intestine (HP:0002037)1.74382685
158Optic nerve hypoplasia (HP:0000609)1.72918955
159Panhypogammaglobulinemia (HP:0003139)1.72280077
160Reduced antithrombin III activity (HP:0001976)1.71363059
161Recurrent lower respiratory tract infections (HP:0002783)1.66764539
162Glomerulopathy (HP:0100820)1.65326475
163Postaxial foot polydactyly (HP:0001830)1.64013124
164Prolonged bleeding time (HP:0003010)1.62152518
165Preaxial hand polydactyly (HP:0001177)1.61643250
166Periodontitis (HP:0000704)1.60888223
167Blue irides (HP:0000635)1.60600849
168Pancreatic cysts (HP:0001737)1.59406454
169Thyroiditis (HP:0100646)1.57618107
170Arterial thrombosis (HP:0004420)1.57448927

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.35661392
2IRAK33.23631279
3IRAK43.16166956
4MAP3K142.97196997
5ZAK2.95350018
6TXK2.86260920
7INSRR2.60754652
8MAP2K32.60431188
9BMPR1B2.37400885
10SIK32.31383438
11MAP3K62.15964407
12FRK2.13230074
13MAP3K21.99201432
14IKBKE1.89656496
15STK161.79811078
16EIF2AK21.75136842
17FGR1.72846253
18KSR21.71620012
19BMPR21.65368574
20ERN11.63600259
21CDK31.63207203
22TNIK1.60459241
23MAP3K31.59318041
24TEC1.58828354
25IRAK11.58185339
26NUAK11.57076278
27GRK61.54197157
28MAP3K131.53162146
29YES11.49859983
30MAP3K121.48937327
31IKBKB1.40808549
32MARK21.40617773
33BLK1.40094213
34ERBB31.39216626
35MAP2K41.38630223
36ACVR1B1.37278954
37CAMKK21.35724223
38NEK61.33751612
39IRAK21.33150968
40ADRBK21.32316805
41GRK71.31115161
42MAP2K71.31007560
43JAK21.30460281
44MAP3K11.29233329
45TAOK11.28710653
46GRK11.27538803
47EPHA31.26942071
48MUSK1.25893905
49JAK31.23966879
50SGK21.21260830
51MAPK151.18258291
52MKNK21.16962290
53KSR11.15877940
54PIK3CG1.10819581
55CHUK1.07712601
56MAP3K111.03452338
57AKT31.03379491
58TGFBR21.02630718
59WNK11.02389394
60BTK0.99637581
61TIE10.98717420
62STK110.97640055
63PINK10.95336189
64MKNK10.95038031
65DAPK20.91536360
66MAPK130.90085238
67MAP4K10.89435906
68STK380.89134686
69KIT0.89021909
70TAOK30.87832614
71JAK10.87465106
72MAP3K50.87443431
73PKN10.87373076
74PRPF4B0.84675682
75MATK0.83371378
76CSF1R0.83127431
77CAMKK10.82307130
78NLK0.81994174
79EPHB10.79110065
80FGFR30.79039005
81SRPK10.77373779
82PDK10.76915214
83RAF10.76577818
84STK240.75662151
85TRPM70.75068612
86TYK20.74353065
87CDK80.74069495
88PIM20.73909001
89MARK30.73334264
90TNK20.73307215
91PDPK10.72387629
92TBK10.72218647
93PRKD20.72082849
94UHMK10.70139887
95LYN0.70046445
96PRKCE0.68970070
97SGK4940.68200582
98SGK2230.68200582
99PTK2B0.66568839
100LCK0.66064413
101RET0.65936064
102FYN0.62980311
103SYK0.62849914
104DYRK1B0.61997134
105PLK40.61538050
106ZAP700.61195187
107HCK0.60761461
108CAMK1G0.60610993
109MAPK70.60201977
110SGK30.60134229
111MAP3K70.60083157
112PRKCQ0.59555978
113VRK10.59268200
114MAP3K90.58503348
115TAOK20.58102196
116FES0.56801258
117BRD40.56751526
118CDK60.56177127
119CSK0.55548506
120MAPK120.54999147
121SIK20.52909012
122PDGFRB0.52378267
123NEK90.52153203
124HIPK20.50356027
125MAPKAPK50.49969099
126FGFR20.48926398
127CAMK1D0.48622543
128NTRK20.47243005
129MOS0.47180103
130RIPK10.45830367
131RIPK40.44217809
132CAMK40.43290606
133STK38L0.42833873
134PRKCZ0.42706595
135TESK10.42407077
136RPS6KC10.42173585
137RPS6KL10.42173585
138CLK10.42100774
139CDK190.41242280
140NTRK30.40049976
141PRKCD0.39928094
142MAPK40.39673483
143MAP2K60.39275608
144PRKG10.38413322
145MYLK0.37502008
146RPS6KB10.36457355
147MARK10.36387883
148ABL10.34688171
149SGK10.34279105
150ADRBK10.33598334
151PIM10.33575244
152DYRK1A0.32682510
153EPHB20.32010006

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046722.65027889
2Graft-versus-host disease_Homo sapiens_hsa053322.60439657
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.47265134
4Primary immunodeficiency_Homo sapiens_hsa053402.30014221
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.26427329
6Allograft rejection_Homo sapiens_hsa053302.25361337
7Asthma_Homo sapiens_hsa053102.20217351
8Autoimmune thyroid disease_Homo sapiens_hsa053202.09061493
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.97569918
10Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.93315497
11SNARE interactions in vesicular transport_Homo sapiens_hsa041301.87756107
12Measles_Homo sapiens_hsa051621.82398551
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.81812170
14Hematopoietic cell lineage_Homo sapiens_hsa046401.81022436
15Nicotine addiction_Homo sapiens_hsa050331.80970507
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.78734622
17Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.77481520
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.64193366
19Dorso-ventral axis formation_Homo sapiens_hsa043201.60475732
20Rheumatoid arthritis_Homo sapiens_hsa053231.60330849
21Leishmaniasis_Homo sapiens_hsa051401.54640274
22Staphylococcus aureus infection_Homo sapiens_hsa051501.50970604
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.50945781
24Fanconi anemia pathway_Homo sapiens_hsa034601.47541224
25Sphingolipid metabolism_Homo sapiens_hsa006001.41133662
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.40829702
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.40519088
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.38209534
29Protein export_Homo sapiens_hsa030601.37928148
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35725363
31Acute myeloid leukemia_Homo sapiens_hsa052211.35075812
32Taste transduction_Homo sapiens_hsa047421.34664925
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.33094282
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.33068250
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29776357
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.29045311
37Non-small cell lung cancer_Homo sapiens_hsa052231.27824516
38Retinol metabolism_Homo sapiens_hsa008301.27185427
39GnRH signaling pathway_Homo sapiens_hsa049121.24461642
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.24270703
41Long-term potentiation_Homo sapiens_hsa047201.22361012
42Malaria_Homo sapiens_hsa051441.21430733
43Lysosome_Homo sapiens_hsa041421.20457356
44ABC transporters_Homo sapiens_hsa020101.20048128
45Neurotrophin signaling pathway_Homo sapiens_hsa047221.18465515
46Phototransduction_Homo sapiens_hsa047441.18407966
47Arachidonic acid metabolism_Homo sapiens_hsa005901.17781882
48Phospholipase D signaling pathway_Homo sapiens_hsa040721.12756797
49Platelet activation_Homo sapiens_hsa046111.11479817
50Serotonergic synapse_Homo sapiens_hsa047261.10428828
51VEGF signaling pathway_Homo sapiens_hsa043701.08813654
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08577259
53Other glycan degradation_Homo sapiens_hsa005111.07731475
54NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07408302
55Type II diabetes mellitus_Homo sapiens_hsa049301.06846741
56Herpes simplex infection_Homo sapiens_hsa051681.05847201
57Pancreatic cancer_Homo sapiens_hsa052121.04767766
58Maturity onset diabetes of the young_Homo sapiens_hsa049501.04556878
59African trypanosomiasis_Homo sapiens_hsa051431.03340012
60ErbB signaling pathway_Homo sapiens_hsa040121.02034827
61Histidine metabolism_Homo sapiens_hsa003401.01391068
62Ether lipid metabolism_Homo sapiens_hsa005651.01157109
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00759486
64Linoleic acid metabolism_Homo sapiens_hsa005911.00723170
65Amoebiasis_Homo sapiens_hsa051461.00429204
66Osteoclast differentiation_Homo sapiens_hsa043800.99893699
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99546644
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.95443115
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95304233
70Chronic myeloid leukemia_Homo sapiens_hsa052200.94988174
71Renal cell carcinoma_Homo sapiens_hsa052110.94895127
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93395480
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.93201346
74Prolactin signaling pathway_Homo sapiens_hsa049170.92832927
75Vitamin digestion and absorption_Homo sapiens_hsa049770.91487815
76Estrogen signaling pathway_Homo sapiens_hsa049150.88963530
77Chemokine signaling pathway_Homo sapiens_hsa040620.87083191
78Morphine addiction_Homo sapiens_hsa050320.86160422
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85860200
80FoxO signaling pathway_Homo sapiens_hsa040680.84893811
81Sulfur metabolism_Homo sapiens_hsa009200.84291537
82Phagosome_Homo sapiens_hsa041450.84244943
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84021056
84Influenza A_Homo sapiens_hsa051640.83805596
85Endocytosis_Homo sapiens_hsa041440.82926476
86Endometrial cancer_Homo sapiens_hsa052130.82463134
87Synaptic vesicle cycle_Homo sapiens_hsa047210.82307726
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81835804
89mTOR signaling pathway_Homo sapiens_hsa041500.81739874
90Choline metabolism in cancer_Homo sapiens_hsa052310.80979363
91Cholinergic synapse_Homo sapiens_hsa047250.80039928
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79950191
93Type I diabetes mellitus_Homo sapiens_hsa049400.79470611
94TNF signaling pathway_Homo sapiens_hsa046680.79415739
95T cell receptor signaling pathway_Homo sapiens_hsa046600.78410287
96Tuberculosis_Homo sapiens_hsa051520.76420488
97MAPK signaling pathway_Homo sapiens_hsa040100.74697329
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73713537
99Glioma_Homo sapiens_hsa052140.73361030
100Complement and coagulation cascades_Homo sapiens_hsa046100.71842571
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.70916542
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70591237
103Toxoplasmosis_Homo sapiens_hsa051450.69497473
104Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69482613
105Chemical carcinogenesis_Homo sapiens_hsa052040.69214487
106Oxytocin signaling pathway_Homo sapiens_hsa049210.68232836
107Pertussis_Homo sapiens_hsa051330.68189623
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67975969
109Notch signaling pathway_Homo sapiens_hsa043300.66964217
110Long-term depression_Homo sapiens_hsa047300.66925504
111Basal transcription factors_Homo sapiens_hsa030220.66718043
112Fatty acid elongation_Homo sapiens_hsa000620.66420846
113GABAergic synapse_Homo sapiens_hsa047270.65286232
114Rap1 signaling pathway_Homo sapiens_hsa040150.63789543
115Ovarian steroidogenesis_Homo sapiens_hsa049130.63204784
116Glutamatergic synapse_Homo sapiens_hsa047240.63169409
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62102111
118Calcium signaling pathway_Homo sapiens_hsa040200.61606009
119Glycosaminoglycan degradation_Homo sapiens_hsa005310.61560287
120Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61248681
121Shigellosis_Homo sapiens_hsa051310.60627148
122Olfactory transduction_Homo sapiens_hsa047400.60172511
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60140656
124Gastric acid secretion_Homo sapiens_hsa049710.59818177
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58929962
126Dopaminergic synapse_Homo sapiens_hsa047280.58617146
127cAMP signaling pathway_Homo sapiens_hsa040240.58373684
128Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57480411
129Regulation of autophagy_Homo sapiens_hsa041400.57398619
130Gap junction_Homo sapiens_hsa045400.56267448
131Legionellosis_Homo sapiens_hsa051340.56175209
132Cocaine addiction_Homo sapiens_hsa050300.53313183
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.53041040
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51884718
135Steroid biosynthesis_Homo sapiens_hsa001000.51606962
136Inositol phosphate metabolism_Homo sapiens_hsa005620.50379047
137Hepatitis C_Homo sapiens_hsa051600.50045325
138Homologous recombination_Homo sapiens_hsa034400.49836161
139Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49701939
140Circadian entrainment_Homo sapiens_hsa047130.48455765
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44917785
142Phenylalanine metabolism_Homo sapiens_hsa003600.43613893
143Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41619458
144Renin secretion_Homo sapiens_hsa049240.40816299
145Collecting duct acid secretion_Homo sapiens_hsa049660.40371159
146Circadian rhythm_Homo sapiens_hsa047100.39469248
147Salmonella infection_Homo sapiens_hsa051320.38705664
148Hepatitis B_Homo sapiens_hsa051610.37744962
149Apoptosis_Homo sapiens_hsa042100.37030747
150Axon guidance_Homo sapiens_hsa043600.36322503
151Antigen processing and presentation_Homo sapiens_hsa046120.35617415
152Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35522348
153Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32677490
154B cell receptor signaling pathway_Homo sapiens_hsa046620.31266296

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