SLC22A16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the organic zwitterion transporter protein family which transports carnitine. The encoded protein has also been shown to transport anticancer drugs like bleomycin (PMID: 20037140) successful treatment has been correlated with the level of activity of this transporter in tumor cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.59591711
2motile cilium assembly (GO:0044458)9.54186445
3spermatid development (GO:0007286)9.34910453
4male meiosis (GO:0007140)9.13829290
5reproduction (GO:0000003)9.13702713
6synaptonemal complex organization (GO:0070193)8.40875323
7cilium movement (GO:0003341)8.36034104
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.26088775
9regulation of cilium movement (GO:0003352)8.17578358
10synaptonemal complex assembly (GO:0007130)8.04796423
11* single fertilization (GO:0007338)6.92722714
12sperm capacitation (GO:0048240)6.91668774
13DNA methylation involved in gamete generation (GO:0043046)6.55910726
14negative regulation of inclusion body assembly (GO:0090084)6.40078524
15male meiosis I (GO:0007141)6.16979439
16* fertilization (GO:0009566)6.11989249
17* spermatogenesis (GO:0007283)6.03757146
18* male gamete generation (GO:0048232)6.01587105
19chromosome organization involved in meiosis (GO:0070192)5.69234288
20* gamete generation (GO:0007276)5.52847866
21ventricular system development (GO:0021591)5.49740754
22cellular process involved in reproduction in multicellular organism (GO:0022412)5.42448900
23germ cell development (GO:0007281)5.38951567
24meiotic nuclear division (GO:0007126)5.36794784
25microtubule depolymerization (GO:0007019)5.32197024
26regulation of inclusion body assembly (GO:0090083)5.21248787
27seminiferous tubule development (GO:0072520)5.02511944
28meiosis I (GO:0007127)5.00260102
29cell recognition (GO:0008037)4.94475890
30calcium ion-dependent exocytosis (GO:0017156)4.90247052
31microtubule severing (GO:0051013)4.82998430
32regulation of microtubule-based movement (GO:0060632)4.82068500
33DNA double-strand break processing (GO:0000729)4.79876182
34meiotic cell cycle (GO:0051321)4.51741931
35protein localization to cilium (GO:0061512)4.47334175
36left/right pattern formation (GO:0060972)4.34863245
37* multicellular organismal reproductive process (GO:0048609)4.33206640
38killing of cells of other organism (GO:0031640)4.20408556
39disruption of cells of other organism (GO:0044364)4.20408556
40spermatid nucleus differentiation (GO:0007289)4.12249457
41monoubiquitinated protein deubiquitination (GO:0035520)4.00855031
42protein polyglutamylation (GO:0018095)3.91915559
43defense response to fungus (GO:0050832)3.89090058
44genitalia morphogenesis (GO:0035112)3.86812502
45gene silencing by RNA (GO:0031047)3.85990902
46chaperone-mediated protein complex assembly (GO:0051131)3.76197670
47intraciliary transport (GO:0042073)3.74322487
48detection of light stimulus involved in visual perception (GO:0050908)3.63580359
49detection of light stimulus involved in sensory perception (GO:0050962)3.63580359
50* organic cation transport (GO:0015695)3.61172677
51chromosome condensation (GO:0030261)3.61145978
52negative regulation of interleukin-8 production (GO:0032717)3.60015257
53replication fork processing (GO:0031297)3.55852696
54DNA packaging (GO:0006323)3.53989611
55synapsis (GO:0007129)3.52192261
56glycerol ether metabolic process (GO:0006662)3.49798689
57* multicellular organismal development (GO:0007275)3.49079297
58serotonin receptor signaling pathway (GO:0007210)3.48995740
59negative regulation of organelle assembly (GO:1902116)3.47425733
60RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.47206646
61L-fucose catabolic process (GO:0042355)3.46410033
62fucose catabolic process (GO:0019317)3.46410033
63L-fucose metabolic process (GO:0042354)3.46410033
64axoneme assembly (GO:0035082)3.44322871
65meiotic cell cycle process (GO:1903046)3.41904639
66protein-cofactor linkage (GO:0018065)3.39878574
67negative regulation of DNA-dependent DNA replication (GO:2000104)3.30859315
68microtubule-based movement (GO:0007018)3.27971300
69regulation of spindle checkpoint (GO:0090231)3.26916593
70regulation of appetite (GO:0032098)3.24987390
71ether metabolic process (GO:0018904)3.22766625
72regulation of centriole replication (GO:0046599)3.19375751
73meiotic chromosome segregation (GO:0045132)3.16404353
74cilium organization (GO:0044782)3.12509739
75regulation of meiosis I (GO:0060631)3.09280703
76protein refolding (GO:0042026)3.07274488
77nuclear pore complex assembly (GO:0051292)3.06504201
78lactate metabolic process (GO:0006089)3.05604268
79rRNA catabolic process (GO:0016075)3.04219947
80maturation of 5.8S rRNA (GO:0000460)2.97280523
81positive regulation of granulocyte differentiation (GO:0030854)2.97181197
82indole-containing compound catabolic process (GO:0042436)2.95440402
83indolalkylamine catabolic process (GO:0046218)2.95440402
84tryptophan catabolic process (GO:0006569)2.95440402
85cilium assembly (GO:0042384)2.95362262
86maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.93750044
87alditol metabolic process (GO:0019400)2.93082752
88purine-containing compound salvage (GO:0043101)2.92730069
89cilium morphogenesis (GO:0060271)2.92409914
90positive regulation of vasculogenesis (GO:2001214)2.90831886
91hemoglobin metabolic process (GO:0020027)2.90582389
92cellular component assembly involved in morphogenesis (GO:0010927)2.89959298
93DNA deamination (GO:0045006)2.89893402
94mitotic sister chromatid cohesion (GO:0007064)2.89167544
95centriole replication (GO:0007099)2.88156695
96DNA catabolic process, exonucleolytic (GO:0000738)2.87923891
97hematopoietic stem cell proliferation (GO:0071425)2.86861723
98polyol catabolic process (GO:0046174)2.86416576
99tryptophan metabolic process (GO:0006568)2.84998530
100response to fungus (GO:0009620)2.84921931
101nucleus organization (GO:0006997)2.84649295
102negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.82927251
103centriole assembly (GO:0098534)2.82406001
104nucleotide-excision repair, DNA gap filling (GO:0006297)2.79758227
105GMP metabolic process (GO:0046037)2.78240843
106mucosal immune response (GO:0002385)2.78209237
107gene silencing (GO:0016458)2.78007315
108DNA integration (GO:0015074)2.77525739
109peptidyl-glutamic acid modification (GO:0018200)2.75811913
110nucleoside diphosphate phosphorylation (GO:0006165)2.75515673
111indolalkylamine metabolic process (GO:0006586)2.71913294
112positive regulation of B cell differentiation (GO:0045579)2.70161144
113microtubule polymerization or depolymerization (GO:0031109)2.70109391
114negative regulation of mast cell activation (GO:0033004)2.69986044
115detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.69796172
116protein K11-linked deubiquitination (GO:0035871)2.68824506
117exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.68810858
118glycolytic process (GO:0006096)2.66203629
119granulocyte differentiation (GO:0030851)2.65723284
120base-excision repair, AP site formation (GO:0006285)2.65410732
121regulation of protein polyubiquitination (GO:1902914)2.62281479
122single strand break repair (GO:0000012)2.61930572
123interferon-gamma secretion (GO:0072643)2.59085187
124carnitine metabolic process (GO:0009437)2.59014694
125preassembly of GPI anchor in ER membrane (GO:0016254)2.58574298
126regulation of growth of symbiont in host (GO:0044126)2.58516744
127negative regulation of growth of symbiont in host (GO:0044130)2.58516744
128negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.58516744
129modulation of growth of symbiont involved in interaction with host (GO:0044144)2.58516744
130nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.57990897
131protoporphyrinogen IX metabolic process (GO:0046501)2.57680360
132organ or tissue specific immune response (GO:0002251)2.57101345
133protein K6-linked ubiquitination (GO:0085020)2.55336378
134protein K63-linked deubiquitination (GO:0070536)2.54938371
135glycerol metabolic process (GO:0006071)2.54925192
136proteasome assembly (GO:0043248)2.53416506
137photoreceptor cell maintenance (GO:0045494)2.52339288
138mitochondrial respiratory chain complex assembly (GO:0033108)2.51400125
139DNA alkylation (GO:0006305)2.50468242
140DNA methylation (GO:0006306)2.50468242
141definitive hemopoiesis (GO:0060216)2.49990241
142regulation of B cell apoptotic process (GO:0002902)2.49709357
143sulfation (GO:0051923)2.49125427
144cytochrome complex assembly (GO:0017004)2.46827853
145pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.46189370
146left/right axis specification (GO:0070986)2.46132123
147sequestering of actin monomers (GO:0042989)2.45355321
148respiratory chain complex IV assembly (GO:0008535)2.45310712
149mismatch repair (GO:0006298)2.45062268
150negative regulation of DNA repair (GO:0045738)2.44910653
151intra-S DNA damage checkpoint (GO:0031573)2.44812335
152negative regulation of B cell apoptotic process (GO:0002903)2.44122159
153regulation of female gonad development (GO:2000194)2.43708252
154postreplication repair (GO:0006301)2.42090776
155neural tube formation (GO:0001841)2.41596135
156protein complex biogenesis (GO:0070271)2.41575736
157regulation of nuclear cell cycle DNA replication (GO:0033262)2.40968217
158pseudouridine synthesis (GO:0001522)2.40591342
159negative regulation of calcium ion transport into cytosol (GO:0010523)2.40370508
160disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.40104694
161killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.40104694
162deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.39673083
163leukotriene biosynthetic process (GO:0019370)2.38794005
164pore complex assembly (GO:0046931)2.38658250
165nuclear pore organization (GO:0006999)2.38521170
166C-terminal protein amino acid modification (GO:0018410)2.38129664
167platelet dense granule organization (GO:0060155)2.37669454
168reciprocal meiotic recombination (GO:0007131)2.37325080
169reciprocal DNA recombination (GO:0035825)2.37325080
170mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.37142145
171NADH dehydrogenase complex assembly (GO:0010257)2.37142145
172cilium or flagellum-dependent cell motility (GO:0001539)14.1987056
173fusion of sperm to egg plasma membrane (GO:0007342)13.4203407
174* sperm motility (GO:0030317)11.8014044
175acrosome assembly (GO:0001675)11.5507740
176sperm-egg recognition (GO:0035036)11.4309788
177multicellular organism reproduction (GO:0032504)11.1269416
178cell wall macromolecule metabolic process (GO:0044036)10.9543789
179cell wall macromolecule catabolic process (GO:0016998)10.9543789
180acrosome reaction (GO:0007340)10.8095985
181axonemal dynein complex assembly (GO:0070286)10.7640219
182binding of sperm to zona pellucida (GO:0007339)10.3491686
183piRNA metabolic process (GO:0034587)10.2753665
184cell-cell recognition (GO:0009988)10.2260048
185plasma membrane fusion (GO:0045026)10.2148929

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.11866873
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.72372276
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.70777584
4IGF1R_20145208_ChIP-Seq_DFB_Human3.25652823
5E2F7_22180533_ChIP-Seq_HELA_Human2.78929232
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.54508448
7GBX2_23144817_ChIP-Seq_PC3_Human2.47672969
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.46478237
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.42547926
10CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.32429391
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25910848
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.25312605
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.22950934
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.20485532
15ZNF274_21170338_ChIP-Seq_K562_Hela2.19340439
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.14226258
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.11079455
18EWS_26573619_Chip-Seq_HEK293_Human2.09168773
19SCL_19346495_ChIP-Seq_HPC-7_Human2.08037191
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.08002735
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.06351215
22EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.03034891
23GATA1_26923725_Chip-Seq_HPCs_Mouse2.02245519
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.3677438
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.99336120
26VDR_23849224_ChIP-Seq_CD4+_Human1.96990464
27VDR_22108803_ChIP-Seq_LS180_Human1.92041735
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.90429820
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.90226190
30FUS_26573619_Chip-Seq_HEK293_Human1.80645589
31TAF15_26573619_Chip-Seq_HEK293_Human1.80008531
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.77064089
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.68456824
34FOXP3_21729870_ChIP-Seq_TREG_Human1.68338333
35ER_23166858_ChIP-Seq_MCF-7_Human1.67792395
36KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.65671730
37LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.64654060
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64373606
39* ELK4_26923725_Chip-Seq_MESODERM_Mouse1.64183056
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.63500522
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.62214662
42* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.61916779
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.60879159
44FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59212253
45STAT1_17558387_ChIP-Seq_HELA_Human1.58665817
46TP53_22573176_ChIP-Seq_HFKS_Human1.58399156
47FOXA1_21572438_ChIP-Seq_LNCaP_Human1.56775941
48KAP1_22055183_ChIP-Seq_ESCs_Mouse1.54672053
49ELK1_19687146_ChIP-ChIP_HELA_Human1.54347979
50WDR5_24793694_ChIP-Seq_LNCAP_Human1.53890886
51RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.49593669
52* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.45744905
53JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.45474426
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44643252
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.43901941
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43596034
57* P300_19829295_ChIP-Seq_ESCs_Human1.43218414
58CBP_20019798_ChIP-Seq_JUKART_Human1.42861966
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42861966
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.39355854
61TAL1_26923725_Chip-Seq_HPCs_Mouse1.39122909
62SOX2_22085726_ChIP-Seq_NPCs_Mouse1.37040402
63MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.35054722
64* GATA3_21867929_ChIP-Seq_CD8_Mouse1.34783788
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34213615
66KDM2B_26808549_Chip-Seq_REH_Human1.33827801
67ETS1_20019798_ChIP-Seq_JURKAT_Human1.33511847
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.32296869
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30763621
70GATA1_22025678_ChIP-Seq_K562_Human1.30479032
71FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28642621
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.28642621
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27649068
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26603386
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26459249
76ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.26103833
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25249827
78CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.25016058
79CREB1_15753290_ChIP-ChIP_HEK293T_Human1.24569186
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24460294
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.23453135
82* LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.21074355
83SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21073957
84FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20962273
85NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.19834057
86MYC_18940864_ChIP-ChIP_HL60_Human1.18996505
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18075393
88* FLI1_21867929_ChIP-Seq_TH2_Mouse1.17087443
89GATA3_21867929_ChIP-Seq_TH1_Mouse1.17010753
90NCOR_22424771_ChIP-Seq_293T_Human1.15630704
91* REST_21632747_ChIP-Seq_MESCs_Mouse1.15309497
92RUNX1_26923725_Chip-Seq_HPCs_Mouse1.14375425
93P53_21459846_ChIP-Seq_SAOS-2_Human1.14305313
94* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.14210650
95CRX_20693478_ChIP-Seq_RETINA_Mouse1.12457772
96NANOG_19829295_ChIP-Seq_ESCs_Human1.12028102
97SOX2_19829295_ChIP-Seq_ESCs_Human1.12028102
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11509977
99SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11490257
100CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11221685
101PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10797021
102GF1_26923725_Chip-Seq_HPCs_Mouse1.10520135
103PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08966047
104SPI1_23547873_ChIP-Seq_NB4_Human1.07866998
105KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.07143556
106AR_20517297_ChIP-Seq_VCAP_Human1.07065213
107TCF4_23295773_ChIP-Seq_U87_Human1.06794081
108OCT4_18555785_Chip-Seq_ESCs_Mouse1.06420805
109IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05717733
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05702550
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05702550
112* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05605232
113RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.05598463
114GATA3_21878914_ChIP-Seq_MCF-7_Human1.05041932
115NANOG_18555785_Chip-Seq_ESCs_Mouse1.05023215
116AR_25329375_ChIP-Seq_VCAP_Human1.04719908
117EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04403572
118PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04301861
119RAD21_21589869_ChIP-Seq_MESCs_Mouse1.04145986
120CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04141394
121IRF1_19129219_ChIP-ChIP_H3396_Human1.04113140
122CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03789045
123SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02741481
124PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02595012
125GATA3_26560356_Chip-Seq_TH2_Human1.02586988
126IRF8_21731497_ChIP-ChIP_J774_Mouse1.01871146
127BCAT_22108803_ChIP-Seq_LS180_Human1.01623444
128CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01517743
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00747986
130CDX2_22108803_ChIP-Seq_LS180_Human1.00034707
131* STAT3_23295773_ChIP-Seq_U87_Human1.00003189
132NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99802166
133KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99663538
134SPI1_26923725_Chip-Seq_HPCs_Mouse0.99199530
135DCP1A_22483619_ChIP-Seq_HELA_Human0.99148093
136* SMAD4_21799915_ChIP-Seq_A2780_Human0.98157612
137RNF2_27304074_Chip-Seq_NSC_Mouse0.98111415
138KLF4_18555785_Chip-Seq_ESCs_Mouse0.97525422
139P53_22387025_ChIP-Seq_ESCs_Mouse0.97109932
140EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96939465
141TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96305835
142* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96180305
143EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95831480
144ERG_20517297_ChIP-Seq_VCAP_Human0.95526205
145ESRRB_18555785_Chip-Seq_ESCs_Mouse0.95259382
146RARA_24833708_ChIP-Seq_LIVER_Mouse0.95227965
147P300_18555785_Chip-Seq_ESCs_Mouse0.95102262
148IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.94647406
149* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94197707
150SMAD4_21741376_ChIP-Seq_EPCs_Human0.94033004
151YY1_22570637_ChIP-Seq_MALME-3M_Human0.94027937
152PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93879950
153SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92552625
154* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92344434
155RXRA_24833708_ChIP-Seq_LIVER_Mouse0.91924868
156ZFP57_27257070_Chip-Seq_ESCs_Mouse0.91222211
157EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.90531875
158* EZH2_27294783_Chip-Seq_NPCs_Mouse0.90355872
159CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90136060
160EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.89939402
161LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89876501
162* ESET_19884257_ChIP-Seq_ESCs_Mouse0.89841592
163CMYC_18555785_Chip-Seq_ESCs_Mouse0.89769758
164PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89641527
165STAT3_18555785_Chip-Seq_ESCs_Mouse0.88505985
166FLI1_21867929_ChIP-Seq_CD8_Mouse0.87815350
167NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.87614448
168* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87008439
169SOX2_21211035_ChIP-Seq_LN229_Human0.85929039
170RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.85591721
171SUZ12_18555785_Chip-Seq_ESCs_Mouse0.84104983
172ELF1_20517297_ChIP-Seq_JURKAT_Human0.83932879
173PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83438215
174PU1_27457419_Chip-Seq_LIVER_Mouse0.83045241
175* MYC_27129775_Chip-Seq_CORNEA_Mouse0.82313553

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.02448825
2MP0001929_abnormal_gametogenesis5.57268580
3MP0008877_abnormal_DNA_methylation5.27602562
4MP0004147_increased_porphyrin_level4.95239123
5MP0002210_abnormal_sex_determination3.82074052
6MP0002653_abnormal_ependyma_morphology3.32006087
7MP0002161_abnormal_fertility/fecundity3.25943805
8MP0001145_abnormal_male_reproductive3.23255080
9MP0003656_abnormal_erythrocyte_physiolo3.04336245
10MP0002396_abnormal_hematopoietic_system2.84309239
11MP0000653_abnormal_sex_gland2.80645577
12MP0008875_abnormal_xenobiotic_pharmacok2.29732045
13MP0003806_abnormal_nucleotide_metabolis2.16962288
14MP0005623_abnormal_meninges_morphology2.08159053
15MP0002160_abnormal_reproductive_system2.05680599
16MP0005410_abnormal_fertilization15.4116053
17MP0005670_abnormal_white_adipose1.98345741
18MP0002138_abnormal_hepatobiliary_system1.96303872
19MP0005646_abnormal_pituitary_gland1.92570268
20MP0003183_abnormal_peptide_metabolism1.90015064
21MP0005075_abnormal_melanosome_morpholog1.89861804
22MP0000372_irregular_coat_pigmentation1.89514279
23MP0006072_abnormal_retinal_apoptosis1.65817058
24MP0003646_muscle_fatigue1.64778367
25MP0005464_abnormal_platelet_physiology1.61288346
26MP0003718_maternal_effect1.58075364
27MP0002876_abnormal_thyroid_physiology1.54433826
28MP0008057_abnormal_DNA_replication1.52240722
29MP0009697_abnormal_copulation1.39862247
30MP0003724_increased_susceptibility_to1.37635911
31MP0005174_abnormal_tail_pigmentation1.36930439
32MP0003195_calcinosis1.35900402
33MP0005310_abnormal_salivary_gland1.35023616
34MP0002282_abnormal_trachea_morphology1.34104318
35MP0002095_abnormal_skin_pigmentation1.33270378
36MP0004233_abnormal_muscle_weight1.32837895
37MP0008058_abnormal_DNA_repair1.31614686
38MP0008872_abnormal_physiological_respon1.30024528
39MP0009046_muscle_twitch1.28407616
40MP0005084_abnormal_gallbladder_morpholo1.27212189
41MP0001968_abnormal_touch/_nociception1.26811463
42MP0006082_CNS_inflammation1.26501725
43MP0001905_abnormal_dopamine_level1.24571819
44MP0001986_abnormal_taste_sensitivity1.23646811
45MP0002148_abnormal_hypersensitivity_rea1.22949766
46MP0000465_gastrointestinal_hemorrhage1.18855075
47MP0002837_dystrophic_cardiac_calcinosis1.18253556
48MP0001984_abnormal_olfaction1.15953315
49MP0001529_abnormal_vocalization1.15753076
50MP0006276_abnormal_autonomic_nervous1.14895713
51MP0010094_abnormal_chromosome_stability1.11786832
52MP0001919_abnormal_reproductive_system1.11725564
53MP0004043_abnormal_pH_regulation1.10274555
54MP0005647_abnormal_sex_gland1.08478599
55MP0009764_decreased_sensitivity_to1.07688016
56MP0005360_urolithiasis1.07514019
57MP0005389_reproductive_system_phenotype1.05666418
58MP0000689_abnormal_spleen_morphology1.01543125
59MP0004142_abnormal_muscle_tone1.00684209
60MP0006292_abnormal_olfactory_placode0.95616757
61MP0005083_abnormal_biliary_tract0.95097132
62MP0002419_abnormal_innate_immunity0.95089855
63MP0002735_abnormal_chemical_nociception0.93512170
64MP0001765_abnormal_ion_homeostasis0.93182852
65MP0003186_abnormal_redox_activity0.93151025
66MP0008873_increased_physiological_sensi0.92565630
67MP0002398_abnormal_bone_marrow0.92363724
68MP0008995_early_reproductive_senescence0.92278699
69MP0003011_delayed_dark_adaptation0.91408110
70MP0006054_spinal_hemorrhage0.90504479
71MP0002736_abnormal_nociception_after0.90273694
72MP0001835_abnormal_antigen_presentation0.88863178
73MP0000230_abnormal_systemic_arterial0.87511560
74MP0002722_abnormal_immune_system0.87416273
75MP0003172_abnormal_lysosome_physiology0.87334826
76MP0005645_abnormal_hypothalamus_physiol0.87186032
77MP0000631_abnormal_neuroendocrine_gland0.85415573
78MP0005025_abnormal_response_to0.84635384
79MP0001486_abnormal_startle_reflex0.82144729
80MP0009745_abnormal_behavioral_response0.79909714
81MP0002420_abnormal_adaptive_immunity0.78791709
82MP0003303_peritoneal_inflammation0.76932036
83MP0001819_abnormal_immune_cell0.76916333
84MP0003786_premature_aging0.76683665
85MP0005220_abnormal_exocrine_pancreas0.76293394
86MP0002452_abnormal_antigen_presenting0.75830693
87MP0008007_abnormal_cellular_replicative0.75313114
88MP0003943_abnormal_hepatobiliary_system0.74695912
89MP0002132_abnormal_respiratory_system0.72748064
90MP0002822_catalepsy0.71810873
91MP0002429_abnormal_blood_cell0.71452301
92MP0002234_abnormal_pharynx_morphology0.68292545
93MP0003878_abnormal_ear_physiology0.66483253
94MP0005377_hearing/vestibular/ear_phenot0.66483253
95MP0000358_abnormal_cell_content/0.64639754
96MP0003950_abnormal_plasma_membrane0.64174163
97MP0003115_abnormal_respiratory_system0.62787684
98MP0000569_abnormal_digit_pigmentation0.61995482
99MP0003111_abnormal_nucleus_morphology0.59013076
100MP0005397_hematopoietic_system_phenotyp0.56603515
101MP0001545_abnormal_hematopoietic_system0.56603515
102MP0003699_abnormal_female_reproductive0.53676011
103MP0009278_abnormal_bone_marrow0.53161379
104MP0002928_abnormal_bile_duct0.52267547
105MP0004808_abnormal_hematopoietic_stem0.49272966
106MP0001293_anophthalmia0.47492436
107MP0010307_abnormal_tumor_latency0.46129593
108MP0005636_abnormal_mineral_homeostasis0.44736234
109MP0003329_amyloid_beta_deposits0.44078272
110MP0004134_abnormal_chest_morphology0.43363670
111MP0001730_embryonic_growth_arrest0.43024843
112MP0001119_abnormal_female_reproductive0.42295932
113MP0001324_abnormal_eye_pigmentation0.41453460
114MP0005666_abnormal_adipose_tissue0.41182454
115MP0002269_muscular_atrophy0.40729772
116MP0004036_abnormal_muscle_relaxation0.40118293
117MP0002102_abnormal_ear_morphology0.39845172
118MP0006036_abnormal_mitochondrial_physio0.37556009
119MP0005253_abnormal_eye_physiology0.36345008
120MP0005551_abnormal_eye_electrophysiolog0.36169608
121MP0002971_abnormal_brown_adipose0.32598648
122MP0005391_vision/eye_phenotype0.32590903
123MP0001661_extended_life_span0.32359139
124MP0001764_abnormal_homeostasis0.31538440
125MP0004019_abnormal_vitamin_homeostasis0.30771873
126MP0000313_abnormal_cell_death0.30161974
127MP0009115_abnormal_fat_cell0.29701586
128MP0003861_abnormal_nervous_system0.29549015
129MP0003077_abnormal_cell_cycle0.28801895
130MP0004811_abnormal_neuron_physiology0.26651541
131MP0002084_abnormal_developmental_patter0.26558328
132MP0001727_abnormal_embryo_implantation0.26482975
133MP0002152_abnormal_brain_morphology0.26075075
134MP0004133_heterotaxia0.25450966
135MP0003633_abnormal_nervous_system0.25267635
136MP0003879_abnormal_hair_cell0.24623151
137MP0006035_abnormal_mitochondrial_morpho0.24507575
138MP0003045_fibrosis0.24095250
139MP0000427_abnormal_hair_cycle0.23211259
140MP0008961_abnormal_basal_metabolism0.21874138
141MP0002092_abnormal_eye_morphology0.21244187
142MP0003787_abnormal_imprinting0.20328666
143MP0001672_abnormal_embryogenesis/_devel0.20054283
144MP0005380_embryogenesis_phenotype0.20054283
145MP0003631_nervous_system_phenotype0.19699294
146MP0001697_abnormal_embryo_size0.19300209
147MP0000534_abnormal_ureter_morphology0.18850386
148MP0000604_amyloidosis0.17382325
149MP0000751_myopathy0.17225020
150MP0003942_abnormal_urinary_system0.16513594
151MP0000015_abnormal_ear_pigmentation0.16254737
152MP0002229_neurodegeneration0.15945842
153MP0003936_abnormal_reproductive_system0.15809017
154MP0002169_no_abnormal_phenotype0.15457879
155MP0002873_normal_phenotype0.15185718
156MP0002108_abnormal_muscle_morphology0.14562944
157MP0003948_abnormal_gas_homeostasis0.14225188
158MP0003984_embryonic_growth_retardation0.14204107
159MP0002405_respiratory_system_inflammati0.13783308
160MP0002080_prenatal_lethality0.13215807
161MP0001851_eye_inflammation0.12885798
162MP0000001_mammalian_phenotype0.12489033
163MP0005195_abnormal_posterior_eye0.12254961
164MP0000432_abnormal_head_morphology0.12006938

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.32669967
2Abnormal respiratory epithelium morphology (HP:0012253)8.74155115
3Abnormal respiratory motile cilium morphology (HP:0005938)8.74155115
4Rhinitis (HP:0012384)8.04098592
5Abnormal ciliary motility (HP:0012262)7.38515139
6Chronic bronchitis (HP:0004469)7.23442340
7Nasal polyposis (HP:0100582)6.52063765
8Infertility (HP:0000789)6.39281783
9Abnormality of the nasal mucosa (HP:0000433)5.34935473
10Bronchiectasis (HP:0002110)4.67546727
11Nephronophthisis (HP:0000090)4.65330520
12Bronchitis (HP:0012387)4.56739922
13Abnormality of the heme biosynthetic pathway (HP:0010472)4.19348678
14Congenital stationary night blindness (HP:0007642)3.74179554
15Male infertility (HP:0003251)3.62140229
16Pancreatic cysts (HP:0001737)3.60448170
17Abnormality of the renal medulla (HP:0100957)3.52973538
18True hermaphroditism (HP:0010459)3.52951009
19Abnormality of the lower motor neuron (HP:0002366)3.38182594
20Panhypogammaglobulinemia (HP:0003139)3.37796101
21Recurrent otitis media (HP:0000403)3.32832839
22Abolished electroretinogram (ERG) (HP:0000550)3.30338643
23Abnormal spermatogenesis (HP:0008669)3.25925836
24Abnormal rod and cone electroretinograms (HP:0008323)3.22818410
25Recurrent sinusitis (HP:0011108)3.21039606
26Abnormality of macular pigmentation (HP:0008002)3.11977114
27Gonadotropin excess (HP:0000837)2.95389765
28Tubulointerstitial nephritis (HP:0001970)2.91298948
29Severe visual impairment (HP:0001141)2.87684810
30Attenuation of retinal blood vessels (HP:0007843)2.86306662
31Abnormality of B cell number (HP:0010975)2.84959796
32Central scotoma (HP:0000603)2.83492732
33Hypochromic microcytic anemia (HP:0004840)2.79887977
34Recurrent bronchitis (HP:0002837)2.78938310
35Molar tooth sign on MRI (HP:0002419)2.78050201
36Abnormality of midbrain morphology (HP:0002418)2.78050201
37Tubular atrophy (HP:0000092)2.77469725
38Medial flaring of the eyebrow (HP:0010747)2.76884473
39Albinism (HP:0001022)2.69629572
40Acute lymphatic leukemia (HP:0006721)2.68771717
41Amyotrophic lateral sclerosis (HP:0007354)2.68514852
42Absent rod-and cone-mediated responses on ERG (HP:0007688)2.66970374
43Decreased electroretinogram (ERG) amplitude (HP:0000654)2.66663085
44Poikilocytosis (HP:0004447)2.66147229
45B lymphocytopenia (HP:0010976)2.64222309
46Tubulointerstitial abnormality (HP:0001969)2.57443321
47Impulsivity (HP:0100710)2.53350047
48Azoospermia (HP:0000027)2.51479788
49Constricted visual fields (HP:0001133)2.44402137
50Generalized aminoaciduria (HP:0002909)2.42497288
51Fibular hypoplasia (HP:0003038)2.39787842
52Metaphyseal dysplasia (HP:0100255)2.38693942
53Abnormality of the prostate (HP:0008775)2.33216563
54Renal cortical cysts (HP:0000803)2.31802983
55Abnormal delayed hypersensitivity skin test (HP:0002963)2.26105755
56Chronic hepatic failure (HP:0100626)2.22167227
57Hepatic necrosis (HP:0002605)2.21132982
58Abnormality of the fovea (HP:0000493)2.17304880
59Postaxial foot polydactyly (HP:0001830)2.17242477
60Aplasia/Hypoplasia of the fovea (HP:0008060)2.15511902
61Hypoplasia of the fovea (HP:0007750)2.15511902
62Tubulointerstitial fibrosis (HP:0005576)2.13549600
63Impaired proprioception (HP:0010831)2.13498402
64Hypoplasia of the capital femoral epiphysis (HP:0003090)2.12974834
65Myositis (HP:0100614)2.12646327
66Stomatitis (HP:0010280)2.08667506
67Aplasia/Hypoplasia of the uvula (HP:0010293)2.06943450
68Chronic mucocutaneous candidiasis (HP:0002728)2.04452257
69Recurrent cutaneous fungal infections (HP:0011370)2.04452257
70Stage 5 chronic kidney disease (HP:0003774)2.03705429
71Hyperglycinemia (HP:0002154)2.03205350
72Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.5843318
73Absent/shortened dynein arms (HP:0200106)12.3778537
74Dynein arm defect of respiratory motile cilia (HP:0012255)12.3778537
75Congenital hepatic fibrosis (HP:0002612)1.99688774
76Prolonged bleeding time (HP:0003010)1.97005423
77Hyperglycinuria (HP:0003108)1.96876520
78Polydipsia (HP:0001959)1.94043676
79Abnormal drinking behavior (HP:0030082)1.94043676
80Abnormality of chromosome stability (HP:0003220)1.93020187
81Nausea (HP:0002018)1.91773507
82Short ribs (HP:0000773)1.91523263
83Hepatocellular necrosis (HP:0001404)1.91387227
84Male pseudohermaphroditism (HP:0000037)1.89749683
85Aplasia/Hypoplasia of the tibia (HP:0005772)1.89519545
86Upper motor neuron abnormality (HP:0002127)1.89184991
87Agammaglobulinemia (HP:0004432)1.88361218
88Abnormality of the renal cortex (HP:0011035)1.87581576
89Bony spicule pigmentary retinopathy (HP:0007737)1.86356333
90Keratoconjunctivitis (HP:0001096)1.85715015
91Small hand (HP:0200055)1.84898102
92Microglossia (HP:0000171)1.84841381
93Abnormality of T cell physiology (HP:0011840)1.84479714
94Oculomotor apraxia (HP:0000657)1.83618139
95Encephalitis (HP:0002383)1.83204978
96Renal dysplasia (HP:0000110)1.83073138
97Absent frontal sinuses (HP:0002688)1.83044044
983-Methylglutaconic aciduria (HP:0003535)1.82464827
99Degeneration of anterior horn cells (HP:0002398)1.81925488
100Abnormality of the anterior horn cell (HP:0006802)1.81925488
101Acute myeloid leukemia (HP:0004808)1.81840398
102Abnormality of lateral ventricle (HP:0030047)1.79845104
103Elevated erythrocyte sedimentation rate (HP:0003565)1.79755878
104Facial diplegia (HP:0001349)1.78578474
105Pendular nystagmus (HP:0012043)1.78276142
106Chronic sinusitis (HP:0011109)1.77645832
107Spastic tetraparesis (HP:0001285)1.77559410
108Chromosomal breakage induced by crosslinking agents (HP:0003221)1.76699034
109Abnormality of dental color (HP:0011073)1.76150338
110Scotoma (HP:0000575)1.75253275
111Facial cleft (HP:0002006)1.75200051
112Neutropenia (HP:0001875)1.75106483
113Chromsome breakage (HP:0040012)1.74541256
114J-shaped sella turcica (HP:0002680)1.73120126
115Sloping forehead (HP:0000340)1.72634304
116Cholecystitis (HP:0001082)1.72151389
117Abnormal gallbladder physiology (HP:0012438)1.72151389
118Granulocytopenia (HP:0001913)1.71262417
119Meckel diverticulum (HP:0002245)1.69926012
120Abnormality of the ileum (HP:0001549)1.69477989
121Myelodysplasia (HP:0002863)1.68971246
122Congenital sensorineural hearing impairment (HP:0008527)1.68471703
123Atrophy/Degeneration involving motor neurons (HP:0007373)1.68414156
124Polyuria (HP:0000103)1.68350556
125Postaxial hand polydactyly (HP:0001162)1.68276626
126Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.67972257
127Absent epiphyses (HP:0010577)1.67972257
128Heterotopia (HP:0002282)1.66927911
129Abnormality of dentin (HP:0010299)1.65109109
130Microcytic anemia (HP:0001935)1.64632184
131Progressive microcephaly (HP:0000253)1.64536322
132Clubbing of toes (HP:0100760)1.64243062
133Abnormality of permanent molar morphology (HP:0011071)1.64148417
134Abnormality of the dental root (HP:0006486)1.64148417
135Taurodontia (HP:0000679)1.64148417
136Retrobulbar optic neuritis (HP:0100654)1.64078712
137Optic neuritis (HP:0100653)1.64078712
138Supernumerary spleens (HP:0009799)1.60586898
139Abnormality of renal excretion (HP:0011036)1.59348033
140Median cleft lip (HP:0000161)1.58481595
141Congenital primary aphakia (HP:0007707)1.54536355
142Abnormality of molar (HP:0011077)1.53827816
143Abnormality of molar morphology (HP:0011070)1.53827816
144Bell-shaped thorax (HP:0001591)1.53784980
145Gait imbalance (HP:0002141)1.53773881
146Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.52856067
147Short thorax (HP:0010306)1.49439218
148Abnormality of the dental pulp (HP:0006479)1.48234675
149Abnormality of ocular smooth pursuit (HP:0000617)1.47846499
150Aplasia/Hypoplasia of the fibula (HP:0006492)1.47703436
151Deformed sella turcica (HP:0002681)1.47323579
152Dyschromatopsia (HP:0007641)1.46178583
153Abnormal biliary tract physiology (HP:0012439)1.45712883
154Bile duct proliferation (HP:0001408)1.45712883
155Aplasia/Hypoplasia of the tongue (HP:0010295)1.42072169
156Pancreatic fibrosis (HP:0100732)1.39775140
157Cystic liver disease (HP:0006706)1.37805598
158Nephropathy (HP:0000112)1.37188462
159Aplasia/Hypoplasia of the lens (HP:0008063)1.37052754
160Cerebellar dysplasia (HP:0007033)1.35909781
161Broad distal phalanx of finger (HP:0009836)1.31327903
162Nephrogenic diabetes insipidus (HP:0009806)1.31176112
163Decreased central vision (HP:0007663)1.30612288
164Abnormality of saccadic eye movements (HP:0000570)1.30446993
165Abnormal urine output (HP:0012590)1.30279833
166Pachygyria (HP:0001302)1.28313755
16711 pairs of ribs (HP:0000878)1.27742049
168Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.26051287
169Short femoral neck (HP:0100864)1.24237991
170Breast carcinoma (HP:0003002)1.23926808
171Choroideremia (HP:0001139)1.23774415
172Conjunctival telangiectasia (HP:0000524)1.23259961
173Decreased motor nerve conduction velocity (HP:0003431)1.20884076

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.68091839
2PDK38.68091839
3PDK25.62788461
4TESK15.34196176
5FRK4.76760577
6PRKD34.31421711
7ICK3.67567393
8ZAK2.84738958
9MAP4K22.75383746
10PTK2B2.60083638
11TAOK32.50850552
12WNK42.42243937
13NUAK12.40761300
14PNCK2.37646306
15STK392.33442081
16KIT2.22621474
17EIF2AK12.21752146
18FLT32.18693956
19EIF2AK32.11422331
20ADRBK22.05205501
21NEK21.97410944
22ACVR1B1.73981528
23TEC1.73091527
24BCKDK1.67182048
25STK381.64930264
26MAPK131.57509366
27MKNK11.51356702
28GRK11.47456472
29INSRR1.46431151
30MAPKAPK31.37017617
31VRK21.34162580
32CSNK1G31.30540208
33VRK11.26766668
34FES1.25041827
35OXSR11.22914347
36TXK1.21627692
37BLK1.18035912
38MKNK21.17007712
39SYK1.12981633
40CSNK1G11.10644196
41PLK21.10378093
42CSNK1G21.10005496
43MAPK151.05631073
44DYRK1B1.05014527
45WNK11.04606984
46CSNK1A1L1.00660307
47RPS6KA40.97932114
48TYRO30.96484753
49PDK10.95249584
50STK30.91238332
51CCNB10.91193028
52PLK30.90213101
53ERBB30.89991997
54NEK10.89104951
55TRIM280.86334057
56PASK0.84796777
57TNK20.84390432
58SCYL20.82377065
59PIK3CG0.79463807
60CDC70.79374901
61MST40.77897318
62WEE10.76558106
63GRK60.75571544
64CDK190.74995849
65LYN0.73645529
66DYRK30.72712587
67TTK0.71215442
68BCR0.69200336
69DYRK20.64607038
70PINK10.60829386
71IRAK10.59715737
72CHEK20.58852544
73SRPK10.58518785
74EIF2AK20.54995261
75BTK0.54707855
76BRD40.53684168
77MAP3K50.52875931
78CDK60.52558908
79LMTK20.52393517
80BMPR20.51896784
81CAMK1G0.51796425
82TLK10.51511428
83CHEK10.51265451
84FER0.51250362
85PRKCE0.50836877
86DAPK10.50227712
87ATR0.49927949
88ITK0.49555712
89ADRBK10.47516887
90TESK20.47346211
91RPS6KA50.47092874
92PLK40.46625759
93PBK0.46482200
94MAP2K40.46227995
95TRPM70.45710036
96MATK0.45629723
97TGFBR10.45522357
98PDPK10.43284273
99MAP2K30.43121310
100EEF2K0.42014092
101RPS6KB20.41727127
102STK38L0.41479052
103MAP3K60.41222082
104PIM10.41093989
105CSNK1A10.39589521
106DAPK20.36570168
107ATM0.36039203
108ABL10.34761772
109CDK120.34472839
110GRK50.33781466
111MTOR0.31476063
112PAK10.31188024
113NTRK20.29151019
114MAP2K60.28931296
115BRSK20.26945587
116PLK10.26562471
117BMPR1B0.25812955
118MUSK0.25447211
119PRKCG0.25195743
120RIPK40.23756286
121PAK20.23118280
122IRAK20.22393154
123CAMKK10.22182709
124PRKAA10.22169842
125RPS6KB10.19744818
126NEK60.18805448
127MAPKAPK50.15454171
128MARK20.15204587
129ZAP700.10735942
130MAP3K40.08662711
131BRAF0.08378631
132BRSK10.08122897
133WNK30.06787584
134PRKCZ0.06497369
135CSNK2A10.06368762
136CDK10.06315222
137PDGFRB0.06237970
138CDK20.06100764
139PRKCQ0.06080684
140MARK30.05928643
141PAK40.05273366
142GSK3B0.04961841
143CSNK1D0.04812650
144STK110.04614460
145MAP2K70.04261388
146BUB10.04211972
147RPS6KA10.03403584
148YES10.03378251
149CSF1R0.03215995
150PRKG10.03160854
151MAPK80.03150096
152PRKDC0.02719662
153CDK30.02557620
154CSNK2A20.02187877
155CDK150.02120136
156EGFR0.01941694
157PRKACG0.01800150
158STK100.01494514
159PAK60.01339436
160TAOK10.01273573
161MAP3K100.00796336
162PRKACB0.00380709
163CDK40.00057694
164CDK14-0.0313217
165CAMK2A-0.0307940
166RPS6KA3-0.0263320
167MAPK10-0.0175162
168RIPK1-0.0155921
169AURKA-0.0144120
170PRKCB-0.0101522
171CDK11A-0.0076868
172CDK18-0.0005472

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.65165729
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.11237961
3Pyruvate metabolism_Homo sapiens_hsa006204.09742125
4Fatty acid biosynthesis_Homo sapiens_hsa000613.39906682
5Propanoate metabolism_Homo sapiens_hsa006403.18470368
6Base excision repair_Homo sapiens_hsa034102.96717896
7Basal transcription factors_Homo sapiens_hsa030222.88104802
8Glucagon signaling pathway_Homo sapiens_hsa049222.80383096
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.68518599
10Pentose phosphate pathway_Homo sapiens_hsa000302.65375154
11Non-homologous end-joining_Homo sapiens_hsa034502.63977533
12Selenocompound metabolism_Homo sapiens_hsa004502.63515845
13Linoleic acid metabolism_Homo sapiens_hsa005912.58671916
14Dorso-ventral axis formation_Homo sapiens_hsa043202.48735879
15Proteasome_Homo sapiens_hsa030502.48162857
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.47150511
17Fanconi anemia pathway_Homo sapiens_hsa034602.44224819
18DNA replication_Homo sapiens_hsa030302.37480463
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.33922505
20Mismatch repair_Homo sapiens_hsa034302.30728385
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.16671893
22Asthma_Homo sapiens_hsa053102.07785114
23Butanoate metabolism_Homo sapiens_hsa006502.05629187
24Glycerolipid metabolism_Homo sapiens_hsa005612.02727337
25Oocyte meiosis_Homo sapiens_hsa041142.01141119
26Nitrogen metabolism_Homo sapiens_hsa009101.91430735
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.87257231
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.80065445
29Huntingtons disease_Homo sapiens_hsa050161.78131681
30Carbohydrate digestion and absorption_Homo sapiens_hsa049731.78081971
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.68368838
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.63153871
33PPAR signaling pathway_Homo sapiens_hsa033201.61181552
34Amphetamine addiction_Homo sapiens_hsa050311.60553304
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.58040473
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.55411628
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.55347446
38Glycerophospholipid metabolism_Homo sapiens_hsa005641.54873589
39Phototransduction_Homo sapiens_hsa047441.54066529
40Tryptophan metabolism_Homo sapiens_hsa003801.46475366
41Fructose and mannose metabolism_Homo sapiens_hsa000511.45019058
42Carbon metabolism_Homo sapiens_hsa012001.44722435
43Nucleotide excision repair_Homo sapiens_hsa034201.44259662
44mRNA surveillance pathway_Homo sapiens_hsa030151.41429368
45RNA transport_Homo sapiens_hsa030131.38495754
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38286938
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.36627704
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.36095734
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.32428270
50Glycosaminoglycan degradation_Homo sapiens_hsa005311.32115154
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31777247
52Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.31608181
53Fat digestion and absorption_Homo sapiens_hsa049751.24829032
54Cardiac muscle contraction_Homo sapiens_hsa042601.24131527
55RNA polymerase_Homo sapiens_hsa030201.23643876
56Renin secretion_Homo sapiens_hsa049241.23447097
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23112429
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20358967
59Olfactory transduction_Homo sapiens_hsa047401.18384375
60Ether lipid metabolism_Homo sapiens_hsa005651.17800077
61Peroxisome_Homo sapiens_hsa041461.16377701
62Antigen processing and presentation_Homo sapiens_hsa046121.15348422
63Regulation of autophagy_Homo sapiens_hsa041401.13942555
64Primary immunodeficiency_Homo sapiens_hsa053401.11895763
65One carbon pool by folate_Homo sapiens_hsa006701.11233696
66Protein export_Homo sapiens_hsa030601.04400214
67Fatty acid metabolism_Homo sapiens_hsa012121.03520612
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00990877
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00115253
70Intestinal immune network for IgA production_Homo sapiens_hsa046721.00079828
71Oxidative phosphorylation_Homo sapiens_hsa001900.98528441
72Purine metabolism_Homo sapiens_hsa002300.97488482
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96153093
74Biosynthesis of amino acids_Homo sapiens_hsa012300.95594198
75Mineral absorption_Homo sapiens_hsa049780.94989756
76Fatty acid degradation_Homo sapiens_hsa000710.93691557
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.87333567
78Fatty acid elongation_Homo sapiens_hsa000620.85659373
79Long-term potentiation_Homo sapiens_hsa047200.85410021
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84812345
81Parkinsons disease_Homo sapiens_hsa050120.83789624
82ABC transporters_Homo sapiens_hsa020100.83124918
83Hematopoietic cell lineage_Homo sapiens_hsa046400.79699195
84Type I diabetes mellitus_Homo sapiens_hsa049400.79317909
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.78945828
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78464866
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78266508
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77625106
89Glutathione metabolism_Homo sapiens_hsa004800.76901748
90Allograft rejection_Homo sapiens_hsa053300.75984055
91Staphylococcus aureus infection_Homo sapiens_hsa051500.74966899
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73206403
93Systemic lupus erythematosus_Homo sapiens_hsa053220.71928290
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71333794
95Estrogen signaling pathway_Homo sapiens_hsa049150.71125417
96beta-Alanine metabolism_Homo sapiens_hsa004100.70906789
97Spliceosome_Homo sapiens_hsa030400.69473681
98Renin-angiotensin system_Homo sapiens_hsa046140.69245297
99Caffeine metabolism_Homo sapiens_hsa002320.68950571
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68500006
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68214053
102African trypanosomiasis_Homo sapiens_hsa051430.67403030
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67036768
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66774627
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.62238299
106Arachidonic acid metabolism_Homo sapiens_hsa005900.59623954
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59282952
108Vitamin digestion and absorption_Homo sapiens_hsa049770.59000629
109N-Glycan biosynthesis_Homo sapiens_hsa005100.57618947
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57321038
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.57263722
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57085641
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.55963662
114Calcium signaling pathway_Homo sapiens_hsa040200.55316955
115Hedgehog signaling pathway_Homo sapiens_hsa043400.55205859
116Chemical carcinogenesis_Homo sapiens_hsa052040.54928519
117Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54558995
118Homologous recombination_Homo sapiens_hsa034400.51045235
119Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50827466
120Legionellosis_Homo sapiens_hsa051340.50825993
121AMPK signaling pathway_Homo sapiens_hsa041520.50578782
122Serotonergic synapse_Homo sapiens_hsa047260.48971513
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48580361
124Autoimmune thyroid disease_Homo sapiens_hsa053200.48488127
125Graft-versus-host disease_Homo sapiens_hsa053320.47557617
126Nicotine addiction_Homo sapiens_hsa050330.47128967
127Endocytosis_Homo sapiens_hsa041440.45386716
128VEGF signaling pathway_Homo sapiens_hsa043700.45057024
129Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44075030
130Insulin secretion_Homo sapiens_hsa049110.43463023
131Collecting duct acid secretion_Homo sapiens_hsa049660.43112999
132Maturity onset diabetes of the young_Homo sapiens_hsa049500.42188823
133NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41999735
134Inositol phosphate metabolism_Homo sapiens_hsa005620.40916698
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40512364
136Histidine metabolism_Homo sapiens_hsa003400.39394010
137Thyroid hormone synthesis_Homo sapiens_hsa049180.38669827
138Herpes simplex infection_Homo sapiens_hsa051680.37214775
139Taste transduction_Homo sapiens_hsa047420.36609466
140Platelet activation_Homo sapiens_hsa046110.35789296
141Metabolic pathways_Homo sapiens_hsa011000.35451606
142Bile secretion_Homo sapiens_hsa049760.34884904
143RNA degradation_Homo sapiens_hsa030180.34491838
144Alcoholism_Homo sapiens_hsa050340.30072409
145Vascular smooth muscle contraction_Homo sapiens_hsa042700.27760126
146Viral carcinogenesis_Homo sapiens_hsa052030.26811125
147Pyrimidine metabolism_Homo sapiens_hsa002400.25495167
148Pancreatic secretion_Homo sapiens_hsa049720.25418981
149Cell cycle_Homo sapiens_hsa041100.24308692
150Synaptic vesicle cycle_Homo sapiens_hsa047210.24024543
151Protein digestion and absorption_Homo sapiens_hsa049740.22251120
152Circadian entrainment_Homo sapiens_hsa047130.20756634
153Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18963829
154Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.18340780
155B cell receptor signaling pathway_Homo sapiens_hsa046620.17514674
156cAMP signaling pathway_Homo sapiens_hsa040240.17379945
157Salivary secretion_Homo sapiens_hsa049700.16470468
158Pentose and glucuronate interconversions_Homo sapiens_hsa000400.16234012
159Wnt signaling pathway_Homo sapiens_hsa043100.15855576
160Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.15443693
161Gastric acid secretion_Homo sapiens_hsa049710.14720664
162Sphingolipid metabolism_Homo sapiens_hsa006000.13260931
163Retinol metabolism_Homo sapiens_hsa008300.12908298
164Salmonella infection_Homo sapiens_hsa051320.12357493

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