ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of short-term neuronal synaptic plasticity (GO:0048172)	5.89117724
2	synaptic vesicle maturation (GO:0016188)	5.71620488
3	locomotory exploration behavior (GO:0035641)	5.58429336
4	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	5.28639647
5	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	5.26189784
6	vocalization behavior (GO:0071625)	5.21684387
7	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	5.07755072
8	synaptic vesicle exocytosis (GO:0016079)	5.05504866
9	glutamate secretion (GO:0014047)	4.76671244
10	regulation of synaptic vesicle exocytosis (GO:2000300)	4.75520964
11	regulation of glutamate receptor signaling pathway (GO:1900449)	4.73738164
12	ionotropic glutamate receptor signaling pathway (GO:0035235)	4.70524228
13	neuron cell-cell adhesion (GO:0007158)	4.67113894
14	protein localization to synapse (GO:0035418)	4.52546628
15	neuronal action potential propagation (GO:0019227)	4.47977908
16	cerebellar granule cell differentiation (GO:0021707)	4.43589183
17	central nervous system myelination (GO:0022010)	4.41776449
18	axon ensheathment in central nervous system (GO:0032291)	4.41776449
19	regulation of neuronal synaptic plasticity (GO:0048168)	4.40812185
20	exploration behavior (GO:0035640)	4.37642066
21	regulation of long-term neuronal synaptic plasticity (GO:0048169)	4.36054552
22	neurotransmitter secretion (GO:0007269)	4.31148920
23	regulation of synaptic vesicle transport (GO:1902803)	4.23132616
24	glutamate receptor signaling pathway (GO:0007215)	4.16508728
25	dendritic spine morphogenesis (GO:0060997)	4.14445507
26	synaptic vesicle docking involved in exocytosis (GO:0016081)	4.12462361
27	synaptic transmission, glutamatergic (GO:0035249)	4.10546922
28	gamma-aminobutyric acid transport (GO:0015812)	4.10454542
29	layer formation in cerebral cortex (GO:0021819)	4.09434924
30	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	4.06288168
31	regulation of synapse structural plasticity (GO:0051823)	4.06109832
32	potassium ion homeostasis (GO:0055075)	4.00697224
33	neuron-neuron synaptic transmission (GO:0007270)	3.89656198
34	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	3.84756604
35	cellular potassium ion homeostasis (GO:0030007)	3.81836100
36	amino acid import (GO:0043090)	3.81370461
37	long-term memory (GO:0007616)	3.81100887
38	transmission of nerve impulse (GO:0019226)	3.79248439
39	potassium ion import (GO:0010107)	3.78775279
40	neuron recognition (GO:0008038)	3.75485969
41	neurotransmitter-gated ion channel clustering (GO:0072578)	3.71438815
42	regulation of excitatory postsynaptic membrane potential (GO:0060079)	3.64959740
43	positive regulation of membrane potential (GO:0045838)	3.63473191
44	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.62719835
45	neurotransmitter transport (GO:0006836)	3.62189045
46	positive regulation of synaptic transmission, GABAergic (GO:0032230)	3.53210475
47	regulation of dendritic spine morphogenesis (GO:0061001)	3.50972708
48	proline transport (GO:0015824)	3.50390656
49	regulation of synapse maturation (GO:0090128)	3.50357877
50	regulation of voltage-gated calcium channel activity (GO:1901385)	3.48576540
51	neuromuscular process controlling posture (GO:0050884)	3.48369032
52	sodium ion export (GO:0071436)	3.47897305
53	regulation of postsynaptic membrane potential (GO:0060078)	3.47081736
54	regulation of synaptic plasticity (GO:0048167)	3.45792596
55	axonal fasciculation (GO:0007413)	3.44055285
56	neuromuscular process controlling balance (GO:0050885)	3.42720556
57	cellular sodium ion homeostasis (GO:0006883)	3.41154947
58	auditory behavior (GO:0031223)	3.40563049
59	neuronal ion channel clustering (GO:0045161)	3.38626383
60	glycine transport (GO:0015816)	3.38126958
61	gamma-aminobutyric acid signaling pathway (GO:0007214)	3.37944612
62	regulation of neurotransmitter levels (GO:0001505)	3.37734665
63	long-term synaptic potentiation (GO:0060291)	3.33543314
64	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.32888986
65	cell migration in hindbrain (GO:0021535)	3.32135799
66	activation of protein kinase A activity (GO:0034199)	3.31436274
67	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.31256943
68	prepulse inhibition (GO:0060134)	3.30269081
69	synaptic vesicle endocytosis (GO:0048488)	3.29013284
70	positive regulation of dendritic spine morphogenesis (GO:0061003)	3.28266773
71	response to auditory stimulus (GO:0010996)	3.28009603
72	establishment of mitochondrion localization (GO:0051654)	3.27287521
73	positive regulation of synaptic transmission, glutamatergic (GO:0051968)	3.27006119
74	regulation of ARF protein signal transduction (GO:0032012)	3.25661047
75	regulation of synaptic transmission, glutamatergic (GO:0051966)	3.25349120
76	regulation of vesicle fusion (GO:0031338)	3.25179709
77	regulation of neurotransmitter secretion (GO:0046928)	3.24083022
78	L-amino acid import (GO:0043092)	3.22469243
79	mating behavior (GO:0007617)	3.21691935
80	postsynaptic membrane organization (GO:0001941)	3.20867382
81	cerebellar Purkinje cell layer development (GO:0021680)	3.20151924
82	regulation of glutamate secretion (GO:0014048)	3.16942583
83	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	3.16115520
84	neuromuscular synaptic transmission (GO:0007274)	3.13469187
85	presynaptic membrane assembly (GO:0097105)	3.12868101
86	adult walking behavior (GO:0007628)	3.11347234
87	dendrite morphogenesis (GO:0048813)	3.10573271
88	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.09824077
89	positive regulation of synapse maturation (GO:0090129)	3.09735119
90	acidic amino acid transport (GO:0015800)	3.08703971
91	membrane hyperpolarization (GO:0060081)	3.08276738
92	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.07686105
93	regulation of neurotransmitter transport (GO:0051588)	3.07374843
94	negative regulation of dendrite morphogenesis (GO:0050774)	3.07231831
95	presynaptic membrane organization (GO:0097090)	3.06769725
96	positive regulation of dendritic spine development (GO:0060999)	3.06338057
97	neurotransmitter uptake (GO:0001504)	3.06028935
98	cerebellar Purkinje cell differentiation (GO:0021702)	3.05926593
99	learning (GO:0007612)	3.05498009
100	cell differentiation in hindbrain (GO:0021533)	3.04123685
101	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	3.03795296
102	membrane depolarization (GO:0051899)	3.03208803
103	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.02279764
104	regulation of dendritic spine development (GO:0060998)	3.00333973
105	positive regulation of neurotransmitter transport (GO:0051590)	3.00085548
106	dendritic spine organization (GO:0097061)	2.99654684
107	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.99023488
108	vesicle transport along microtubule (GO:0047496)	2.98440337
109	cell communication by electrical coupling (GO:0010644)	2.97115884
110	synaptic transmission (GO:0007268)	2.96096351
111	positive regulation of neurotransmitter secretion (GO:0001956)	2.95738529
112	regulation of synaptic transmission (GO:0050804)	2.94117279
113	behavioral defense response (GO:0002209)	2.93814538
114	behavioral fear response (GO:0001662)	2.93814538
115	establishment of synaptic vesicle localization (GO:0097480)	2.93384275
116	synaptic vesicle transport (GO:0048489)	2.93384275
117	positive regulation of synaptic transmission (GO:0050806)	2.92796645
118	synapse assembly (GO:0007416)	2.92601385
119	regulation of female receptivity (GO:0045924)	2.91650448
120	membrane depolarization during action potential (GO:0086010)	2.90584698
121	negative regulation of amino acid transport (GO:0051956)	2.90057236
122	G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)	2.89226645
123	neuromuscular process (GO:0050905)	2.88058164

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.96288277
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.31961402
3	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	3.20342433
4	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	3.15832399
5	JARID2_20064375_ChIP-Seq_MESCs_Mouse	3.14957682
6	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.81099984
7	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.81099984
8	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.74223448
9	REST_21632747_ChIP-Seq_MESCs_Mouse	2.72898076
10	* RARB_27405468_Chip-Seq_BRAIN_Mouse	2.68362539
11	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	2.67768417
12	* MTF2_20144788_ChIP-Seq_MESCs_Mouse	2.62297991
13	* SUZ12_20075857_ChIP-Seq_MESCs_Mouse	2.61221650
14	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.61134545
15	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.59243153
16	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	2.57851589
17	DROSHA_22980978_ChIP-Seq_HELA_Human	2.51715311
18	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.37974980
19	* SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.37765565
20	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.36986602
21	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.30098068
22	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.25508058
23	RNF2_27304074_Chip-Seq_ESCs_Mouse	2.24832540
24	REST_18959480_ChIP-ChIP_MESCs_Mouse	2.24104607
25	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.12366074
26	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.06597393
27	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.04711175
28	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	2.00048601
29	AR_21572438_ChIP-Seq_LNCaP_Human	1.91357914
30	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.84975147
31	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.82810287
32	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.70829405
33	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.67662837
34	TAF15_26573619_Chip-Seq_HEK293_Human	1.64959989
35	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.60547132
36	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.56298065
37	SMAD4_21799915_ChIP-Seq_A2780_Human	1.48447649
38	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.42620821
39	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.42124506
40	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.39133482
41	ZNF274_21170338_ChIP-Seq_K562_Hela	1.34649777
42	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.34316378
43	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.32346475
44	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.30749342
45	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.28502394
46	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.28476597
47	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.27972894
48	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.27906648
49	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.27267452
50	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.25372045
51	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.24596827
52	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24082197
53	P300_19829295_ChIP-Seq_ESCs_Human	1.22212049
54	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.21677070
55	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.21265458
56	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.20652300
57	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.16866502
58	* WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.16453952
59	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.15265173
60	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.14620331
61	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.14231662
62	AR_19668381_ChIP-Seq_PC3_Human	1.12383766
63	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12227035
64	STAT3_23295773_ChIP-Seq_U87_Human	1.11961749
65	AR_25329375_ChIP-Seq_VCAP_Human	1.11474581
66	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.10921852
67	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.07764708
68	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07641645
69	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.07523743
70	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.05458246
71	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.05424919
72	* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.04988656
73	KDM2B_26808549_Chip-Seq_K562_Human	1.04755507
74	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.04266119
75	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.03752880
76	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.03298598
77	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.02929973
78	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.02159166
79	RNF2_27304074_Chip-Seq_NSC_Mouse	1.01543035
80	* P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.01267142
81	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.01053701
82	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.00801154
83	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.98885185
84	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.98058493
85	TCF4_23295773_ChIP-Seq_U87_Human	0.97977528
86	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.97930864
87	IGF1R_20145208_ChIP-Seq_DFB_Human	0.96285426
88	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.94392878
89	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.93002248
90	YAP1_20516196_ChIP-Seq_MESCs_Mouse	0.92782457
91	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.92589811
92	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.91995597
93	LXR_22292898_ChIP-Seq_THP-1_Human	0.91892084
94	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.91803305
95	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.91713393
96	RUNX2_22187159_ChIP-Seq_PCA_Human	0.91519716
97	AHR_22903824_ChIP-Seq_MCF-7_Human	0.90769830
98	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.90580475
99	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.90007638
100	OCT4_19829295_ChIP-Seq_ESCs_Human	0.89837923
101	CTCF_27219007_Chip-Seq_Bcells_Human	0.89650902
102	SMAD_19615063_ChIP-ChIP_OVARY_Human	0.89619066
103	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	0.89228263
104	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.88801919
105	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.87690870
106	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.86167818
107	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.85836727
108	TET1_21490601_ChIP-Seq_MESCs_Mouse	0.84428288
109	KDM2B_26808549_Chip-Seq_SUP-B15_Human	0.84174023
110	TP53_16413492_ChIP-PET_HCT116_Human	0.84147069
111	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.83919717
112	DPY_21335234_ChIP-Seq_ESCs_Mouse	0.83847453
113	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.83768986
114	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.82056113
115	SMC4_20622854_ChIP-Seq_HELA_Human	0.81673146
116	ER_23166858_ChIP-Seq_MCF-7_Human	0.80805197
117	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	0.80672845
118	JUN_21703547_ChIP-Seq_K562_Human	0.80466866
119	FUS_26573619_Chip-Seq_HEK293_Human	0.80266554
120	KLF4_19829295_ChIP-Seq_ESCs_Human	0.79864934
121	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.76649804
122	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.75313089
123	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.75313089
124	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.75147000
125	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.73871389
126	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	0.73154029
127	RUNX1_26923725_Chip-Seq_HPCs_Mouse	0.72647987
128	SMAD4_21741376_ChIP-Seq_ESCs_Human	0.72255042
129	TRIM28_21343339_ChIP-Seq_HEK293_Human	0.71453392

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004859_abnormal_synaptic_plasticity	6.24906043
2	MP0003880_abnormal_central_pattern	5.12841576
3	MP0003635_abnormal_synaptic_transmissio	4.11258484
4	MP0004270_analgesia	3.51435865
5	MP0009745_abnormal_behavioral_response	3.47161324
6	MP0002064_seizures	3.25494729
7	MP0002063_abnormal_learning/memory/cond	3.24627946
8	MP0002822_catalepsy	3.02331394
9	MP0009046_muscle_twitch	3.01958263
10	MP0005423_abnormal_somatic_nervous	2.97639201
11	MP0001968_abnormal_touch/_nociception	2.86786159
12	MP0002572_abnormal_emotion/affect_behav	2.76796565
13	MP0002272_abnormal_nervous_system	2.70841717
14	MP0001486_abnormal_startle_reflex	2.67200325
15	MP0002734_abnormal_mechanical_nocicepti	2.48657162
16	MP0001501_abnormal_sleep_pattern	2.28106930
17	MP0001440_abnormal_grooming_behavior	2.19263786
18	MP0002736_abnormal_nociception_after	2.18511728
19	MP0003329_amyloid_beta_deposits	2.06942593
20	MP0002733_abnormal_thermal_nociception	1.99781649
21	MP0001970_abnormal_pain_threshold	1.94872272
22	MP0002067_abnormal_sensory_capabilities	1.92088657
23	MP0002735_abnormal_chemical_nociception	1.89653016
24	MP0000778_abnormal_nervous_system	1.86152867
25	MP0008569_lethality_at_weaning	1.85856557
26	MP0001529_abnormal_vocalization	1.79685102
27	MP0002557_abnormal_social/conspecific_i	1.75225589
28	MP0004924_abnormal_behavior	1.74672404
29	MP0005386_behavior/neurological_phenoty	1.74672404
30	MP0004885_abnormal_endolymph	1.74017397
31	MP0006276_abnormal_autonomic_nervous	1.73189918
32	MP0002184_abnormal_innervation	1.71415188
33	MP0009780_abnormal_chondrocyte_physiolo	1.70765130
34	MP0004811_abnormal_neuron_physiology	1.64382157
35	MP0001905_abnormal_dopamine_level	1.62623342
36	MP0004858_abnormal_nervous_system	1.61986298
37	MP0000955_abnormal_spinal_cord	1.61888285
38	MP0003122_maternal_imprinting	1.60899923
39	MP0004142_abnormal_muscle_tone	1.60479449
40	MP0005646_abnormal_pituitary_gland	1.60221784
41	MP0002909_abnormal_adrenal_gland	1.58373036
42	MP0005645_abnormal_hypothalamus_physiol	1.55269072
43	MP0001984_abnormal_olfaction	1.49534769
44	MP0002066_abnormal_motor_capabilities/c	1.46384488
45	MP0002882_abnormal_neuron_morphology	1.45779513
46	MP0000920_abnormal_myelination	1.39950654
47	MP0001502_abnormal_circadian_rhythm	1.37200360
48	MP0003633_abnormal_nervous_system	1.36578330
49	MP0003879_abnormal_hair_cell	1.34095033
50	MP0003787_abnormal_imprinting	1.29622802
51	MP0003690_abnormal_glial_cell	1.27554644
52	MP0003631_nervous_system_phenotype	1.19593541
53	MP0002152_abnormal_brain_morphology	1.12102178
54	MP0003634_abnormal_glial_cell	1.11861059
55	MP0002229_neurodegeneration	1.09852479
56	MP0004742_abnormal_vestibular_system	1.08517704
57	MP0000751_myopathy	1.02954677
58	MP0000013_abnormal_adipose_tissue	0.98652928
59	MP0003121_genomic_imprinting	0.98065335
60	MP0005551_abnormal_eye_electrophysiolog	0.97885086
61	MP0002653_abnormal_ependyma_morphology	0.97798217
62	MP0004145_abnormal_muscle_electrophysio	0.96408915
63	MP0001177_atelectasis	0.96279176
64	MP0003632_abnormal_nervous_system	0.95199230
65	MP0008872_abnormal_physiological_respon	0.94575688
66	MP0002069_abnormal_eating/drinking_beha	0.94192837
67	MP0003283_abnormal_digestive_organ	0.91364273
68	MP0000604_amyloidosis	0.90874262
69	MP0001188_hyperpigmentation	0.90334150
70	MP0003075_altered_response_to	0.89374276
71	MP0001485_abnormal_pinna_reflex	0.87389542
72	MP0005409_darkened_coat_color	0.86595852
73	MP0001963_abnormal_hearing_physiology	0.86518873
74	MP0008874_decreased_physiological_sensi	0.85043860
75	MP0000631_abnormal_neuroendocrine_gland	0.81799719
76	MP0002752_abnormal_somatic_nervous	0.81694776
77	MP0005535_abnormal_body_temperature	0.81013161
78	MP0008877_abnormal_DNA_methylation	0.80148652
79	MP0004085_abnormal_heartbeat	0.79092530
80	MP0008961_abnormal_basal_metabolism	0.76304872
81	MP0000566_synostosis	0.76134059
82	MP0005623_abnormal_meninges_morphology	0.74188265
83	MP0005394_taste/olfaction_phenotype	0.73837229
84	MP0005499_abnormal_olfactory_system	0.73837229
85	MP0001986_abnormal_taste_sensitivity	0.73826150
86	MP0002090_abnormal_vision	0.73282815
87	MP0005167_abnormal_blood-brain_barrier	0.73218484
88	MP0010386_abnormal_urinary_bladder	0.71254376
89	MP0003137_abnormal_impulse_conducting	0.69980837
90	MP0001348_abnormal_lacrimal_gland	0.65011398
91	MP0001299_abnormal_eye_distance/	0.64541426
92	MP0001664_abnormal_digestion	0.64354009
93	MP0002837_dystrophic_cardiac_calcinosis	0.64238346
94	MP0002638_abnormal_pupillary_reflex	0.62853779
95	MP0003938_abnormal_ear_development	0.62620307
96	MP0004043_abnormal_pH_regulation	0.62272108
97	MP0000579_abnormal_nail_morphology	0.61229882
98	MP0004147_increased_porphyrin_level	0.60016994
99	MP0001346_abnormal_lacrimal_gland	0.59909002
100	MP0006072_abnormal_retinal_apoptosis	0.59200301
101	MP0001943_abnormal_respiration	0.58980257
102	MP0000747_muscle_weakness	0.58017551
103	MP0004130_abnormal_muscle_cell	0.56954551
104	MP0002249_abnormal_larynx_morphology	0.56703247
105	MP0004133_heterotaxia	0.56599577
106	MP0002082_postnatal_lethality	0.55927613
107	MP0003861_abnormal_nervous_system	0.55210021
108	MP0005171_absent_coat_pigmentation	0.54877393
109	MP0010768_mortality/aging	0.54785381
110	MP0003123_paternal_imprinting	0.53201095
111	MP0003172_abnormal_lysosome_physiology	0.52551863
112	MP0010769_abnormal_survival	0.51262474
113	MP0004215_abnormal_myocardial_fiber	0.50488481
114	MP0000026_abnormal_inner_ear	0.50097309
115	MP0010770_preweaning_lethality	0.49592629

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Focal motor seizures (HP:0011153)	7.18675382
2	Myokymia (HP:0002411)	7.08243167
3	Focal seizures (HP:0007359)	5.44597259
4	Visual hallucinations (HP:0002367)	5.14967904
5	Epileptic encephalopathy (HP:0200134)	4.35699554
6	Atonic seizures (HP:0010819)	4.24541295
7	Supranuclear gaze palsy (HP:0000605)	4.24459685
8	Progressive cerebellar ataxia (HP:0002073)	3.94873931
9	Action tremor (HP:0002345)	3.84746217
10	Absence seizures (HP:0002121)	3.81996090
11	Febrile seizures (HP:0002373)	3.78057850
12	Ankle clonus (HP:0011448)	3.74505409
13	Neurofibrillary tangles (HP:0002185)	3.71688825
14	Generalized tonic-clonic seizures (HP:0002069)	3.64325700
15	Dialeptic seizures (HP:0011146)	3.58001618
16	Cerebral inclusion bodies (HP:0100314)	3.41937766
17	Obstructive sleep apnea (HP:0002870)	3.37837873
18	Dysmetria (HP:0001310)	3.34909626
19	Depression (HP:0000716)	3.29159367
20	Broad-based gait (HP:0002136)	3.25259659
21	Anxiety (HP:0000739)	3.21869281
22	Impaired vibration sensation in the lower limbs (HP:0002166)	3.17213329
23	Dysdiadochokinesis (HP:0002075)	3.11495498
24	Mutism (HP:0002300)	3.10996139
25	Abnormal eating behavior (HP:0100738)	3.08597584
26	Cerebral hypomyelination (HP:0006808)	3.07805084
27	Poor eye contact (HP:0000817)	3.07223118
28	Sleep apnea (HP:0010535)	2.99268296
29	Postural instability (HP:0002172)	2.96497498
30	Truncal ataxia (HP:0002078)	2.96191357
31	Urinary bladder sphincter dysfunction (HP:0002839)	2.95299690
32	Gaze-evoked nystagmus (HP:0000640)	2.93264252
33	Spastic gait (HP:0002064)	2.92754595
34	Intention tremor (HP:0002080)	2.83279143
35	Abnormal social behavior (HP:0012433)	2.79672758
36	Impaired social interactions (HP:0000735)	2.79672758
37	Hemiparesis (HP:0001269)	2.78772301
38	Tetraplegia (HP:0002445)	2.77508024
39	Abnormality of the corticospinal tract (HP:0002492)	2.77366347
40	Urinary urgency (HP:0000012)	2.75836098
41	Scanning speech (HP:0002168)	2.75040468
42	Hyperventilation (HP:0002883)	2.71353960
43	Amblyopia (HP:0000646)	2.69012987
44	Torticollis (HP:0000473)	2.68402004
45	Progressive inability to walk (HP:0002505)	2.67792266
46	Megalencephaly (HP:0001355)	2.64809794
47	Limb dystonia (HP:0002451)	2.61982565
48	Termporal pattern (HP:0011008)	2.53908239
49	Insidious onset (HP:0003587)	2.53908239
50	Abnormality of binocular vision (HP:0011514)	2.51246188
51	Diplopia (HP:0000651)	2.51246188
52	Focal dystonia (HP:0004373)	2.49857064
53	Papilledema (HP:0001085)	2.47538561
54	Hemiplegia (HP:0002301)	2.43224210
55	Bradykinesia (HP:0002067)	2.42958329
56	Drooling (HP:0002307)	2.42397793
57	Excessive salivation (HP:0003781)	2.42397793
58	Pheochromocytoma (HP:0002666)	2.41383070
59	Genetic anticipation (HP:0003743)	2.41152037
60	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.39931726
61	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.39931726
62	Polyphagia (HP:0002591)	2.39094371
63	Lower limb muscle weakness (HP:0007340)	2.37312529
64	Abnormality of the lower motor neuron (HP:0002366)	2.33757041
65	Ventricular fibrillation (HP:0001663)	2.26992801
66	Craniofacial dystonia (HP:0012179)	2.25905784
67	Peripheral hypomyelination (HP:0007182)	2.21654563
68	Impaired smooth pursuit (HP:0007772)	2.21476544
69	Stereotypic behavior (HP:0000733)	2.20180352
70	Epileptiform EEG discharges (HP:0011182)	2.19707138
71	Neuronal loss in central nervous system (HP:0002529)	2.18276786
72	Apathy (HP:0000741)	2.17745911
73	Retinal dysplasia (HP:0007973)	2.16382527
74	Insomnia (HP:0100785)	2.16331717
75	Generalized myoclonic seizures (HP:0002123)	2.16209866
76	EEG with generalized epileptiform discharges (HP:0011198)	2.13734440
77	Morphological abnormality of the pyramidal tract (HP:0002062)	2.11757241
78	Spastic tetraparesis (HP:0001285)	2.10590504
79	Increased circulating renin level (HP:0000848)	2.08838598
80	Psychosis (HP:0000709)	2.07719897
81	Neuroendocrine neoplasm (HP:0100634)	2.04663491
82	Hypsarrhythmia (HP:0002521)	2.04364188
83	Status epilepticus (HP:0002133)	2.04081034
84	Delusions (HP:0000746)	2.02574882
85	Absent speech (HP:0001344)	2.02318325
86	Clonus (HP:0002169)	2.01419119
87	Turricephaly (HP:0000262)	2.01202500
88	Aplasia involving bones of the extremities (HP:0009825)	1.99351822
89	Aplasia involving bones of the upper limbs (HP:0009823)	1.99351822
90	Aplasia of the phalanges of the hand (HP:0009802)	1.99351822
91	Impaired vibratory sensation (HP:0002495)	1.99030776
92	Diminished motivation (HP:0000745)	1.98673285
93	Fetal akinesia sequence (HP:0001989)	1.98100248
94	Annular pancreas (HP:0001734)	1.97267293
95	Rigidity (HP:0002063)	1.97148463
96	Abnormality of ocular smooth pursuit (HP:0000617)	1.96730000
97	Choreoathetosis (HP:0001266)	1.96524332
98	CNS hypomyelination (HP:0003429)	1.96304451
99	Failure to thrive in infancy (HP:0001531)	1.95629466
100	Agitation (HP:0000713)	1.95316319
101	Rapidly progressive (HP:0003678)	1.93040103
102	Spinal canal stenosis (HP:0003416)	1.92216296
103	Gait ataxia (HP:0002066)	1.88224134
104	Bronchomalacia (HP:0002780)	1.86420384
105	Incomplete penetrance (HP:0003829)	1.84508543
106	Type II lissencephaly (HP:0007260)	1.83969297
107	Inability to walk (HP:0002540)	1.83744376
108	Spastic tetraplegia (HP:0002510)	1.83500168
109	Lower limb asymmetry (HP:0100559)	1.83343768
110	Abnormal EKG (HP:0003115)	1.81251482
111	Specific learning disability (HP:0001328)	1.80453062
112	Abnormality of saccadic eye movements (HP:0000570)	1.79867691
113	Split foot (HP:0001839)	1.79271141
114	Akinesia (HP:0002304)	1.79016125
115	Blue irides (HP:0000635)	1.77994977
116	Pointed chin (HP:0000307)	1.77509087
117	Hypoventilation (HP:0002791)	1.76337619
118	Hyperthyroidism (HP:0000836)	1.72489156

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA4	4.60192472
2	NTRK3	4.36057656
3	MAP3K9	3.83439767
4	MARK1	2.73629377
5	MAP3K4	2.68950045
6	MINK1	2.54928265
7	PAK6	2.25039532
8	KSR2	2.22903528
9	NTRK2	2.21279742
10	MAP2K7	2.13866087
11	DAPK2	2.11952622
12	NTRK1	2.00966093
13	PRKD3	1.99937690
14	RIPK4	1.83173951
15	MAP3K12	1.82297245
16	ARAF	1.81058135
17	TNIK	1.78454601
18	PNCK	1.76737749
19	CAMKK1	1.63787212
20	MAP2K4	1.63496903
21	CDK5	1.59690925
22	KSR1	1.56686380
23	CDK19	1.48353272
24	MAP3K13	1.47985424
25	TYRO3	1.45790031
26	UHMK1	1.41803883
27	FES	1.39636196
28	CASK	1.38995535
29	GRK5	1.37559501
30	RIPK1	1.36455291
31	PLK2	1.31078063
32	OXSR1	1.25950628
33	PRPF4B	1.24983322
34	MAPK13	1.22227004
35	SIK2	1.19769891
36	PRKCG	1.16112218
37	STK38	1.14746613
38	DAPK1	1.12685617
39	MAP3K2	1.10919655
40	STK39	1.10717698
41	PHKG1	1.08505115
42	PHKG2	1.08505115
43	CAMK2A	1.06015182
44	CAMK2B	1.00953549
45	CDK15	0.98555916
46	CDK18	0.98511631
47	SGK223	0.96980107
48	SGK494	0.96980107
49	CDK14	0.96858200
50	PRKCH	0.89768322
51	CAMKK2	0.88817723
52	CDK11A	0.86856872
53	STK11	0.86481584
54	CAMK1	0.85515183
55	PAK3	0.85393461
56	LMTK2	0.81869847
57	RAF1	0.81211575
58	CSNK1G2	0.80959093
59	PTK2B	0.78105936
60	PINK1	0.76373477
61	LATS2	0.75573507
62	TAOK1	0.73516176
63	MAPK12	0.73119653
64	MARK2	0.72994065
65	BMPR2	0.72195905
66	TNK2	0.71930427
67	FGR	0.71879225
68	RET	0.71736939
69	MAPKAPK5	0.70693455
70	WNK1	0.69852048
71	NEK6	0.69251825
72	LIMK1	0.69211734
73	MAP3K11	0.69053410
74	DYRK1A	0.68204851
75	DYRK2	0.67358078
76	CAMK2D	0.67275032
77	ALK	0.66195063
78	CAMK2G	0.65862742
79	BRSK1	0.64579179
80	SGK1	0.63652338
81	PDPK1	0.61894027
82	CAMK4	0.61319883
83	MAP3K1	0.59974208
84	CAMK1G	0.58586302
85	ROCK2	0.56666829
86	WNK4	0.56632482
87	PDK1	0.55673005
88	PKN1	0.54832779
89	BCR	0.54526438
90	PRKCE	0.52012460
91	FYN	0.49993183
92	PRKCZ	0.49422159
93	NME1	0.47720284
94	MUSK	0.47107820
95	SGK2	0.47037156
96	RPS6KA3	0.46974354
97	ERBB2	0.46907036
98	FGFR2	0.46435449
99	MAPK10	0.46420221
100	CDC42BPA	0.46412387
101	SGK3	0.43033570
102	ROCK1	0.41253122
103	CSNK1G3	0.40077923
104	FER	0.38519536
105	TESK1	0.38389053
106	DAPK3	0.36355176
107	ICK	0.35516287
108	MOS	0.35102391
109	PRKCA	0.34968130
110	BRAF	0.34620794
111	DDR2	0.33495276
112	PRKACA	0.31429571
113	RPS6KA2	0.31373319
114	MAP2K6	0.31359680
115	MAPK8	0.30471036
116	PRKG1	0.30331669
117	SRC	0.28143481
118	CSNK1E	0.26267670
119	CSNK1D	0.26222983

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.70607032
2	Synaptic vesicle cycle_Homo sapiens_hsa04721	3.27473579
3	GABAergic synapse_Homo sapiens_hsa04727	2.83503566
4	Olfactory transduction_Homo sapiens_hsa04740	2.74321079
5	Circadian entrainment_Homo sapiens_hsa04713	2.65258252
6	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.63340088
7	Glutamatergic synapse_Homo sapiens_hsa04724	2.62883889
8	Long-term potentiation_Homo sapiens_hsa04720	2.56337365
9	Morphine addiction_Homo sapiens_hsa05032	2.51807298
10	Amphetamine addiction_Homo sapiens_hsa05031	2.46798718
11	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	2.22200119
12	Dopaminergic synapse_Homo sapiens_hsa04728	2.15483974
13	Salivary secretion_Homo sapiens_hsa04970	2.14207086
14	Gastric acid secretion_Homo sapiens_hsa04971	1.93704065
15	Insulin secretion_Homo sapiens_hsa04911	1.90790291
16	Cocaine addiction_Homo sapiens_hsa05030	1.88905367
17	Cholinergic synapse_Homo sapiens_hsa04725	1.88291734
18	Long-term depression_Homo sapiens_hsa04730	1.74501447
19	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.73507402
20	Taste transduction_Homo sapiens_hsa04742	1.72381403
21	Serotonergic synapse_Homo sapiens_hsa04726	1.72300518
22	Renin secretion_Homo sapiens_hsa04924	1.68107580
23	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.64310901
24	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.61685962
25	Collecting duct acid secretion_Homo sapiens_hsa04966	1.60839687
26	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.57984624
27	Calcium signaling pathway_Homo sapiens_hsa04020	1.55771020
28	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.44939791
29	GnRH signaling pathway_Homo sapiens_hsa04912	1.42881040
30	Gap junction_Homo sapiens_hsa04540	1.37355667
31	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.26339704
32	cAMP signaling pathway_Homo sapiens_hsa04024	1.25749796
33	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.25027681
34	Axon guidance_Homo sapiens_hsa04360	1.21923280
35	Cardiac muscle contraction_Homo sapiens_hsa04260	1.19564946
36	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.15887942
37	Estrogen signaling pathway_Homo sapiens_hsa04915	1.11294866
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.11227304
39	Vibrio cholerae infection_Homo sapiens_hsa05110	1.08766183
40	Melanogenesis_Homo sapiens_hsa04916	1.07125810
41	Nitrogen metabolism_Homo sapiens_hsa00910	1.04987798
42	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.02739132
43	Glioma_Homo sapiens_hsa05214	1.01789048
44	Type II diabetes mellitus_Homo sapiens_hsa04930	0.98792424
45	ErbB signaling pathway_Homo sapiens_hsa04012	0.96277201
46	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.96181248
47	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.94139265
48	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.93778114
49	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.88605676
50	Pancreatic secretion_Homo sapiens_hsa04972	0.86922757
51	Phototransduction_Homo sapiens_hsa04744	0.83383631
52	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.82487709
53	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.79167023
54	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.77692479
55	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.77250337
56	Oocyte meiosis_Homo sapiens_hsa04114	0.77211598
57	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.74423684
58	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.72750282
59	Alzheimers disease_Homo sapiens_hsa05010	0.71457987
60	Choline metabolism in cancer_Homo sapiens_hsa05231	0.70180518
61	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.69027858
62	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.68991684
63	MAPK signaling pathway_Homo sapiens_hsa04010	0.65133626
64	Oxidative phosphorylation_Homo sapiens_hsa00190	0.64442712
65	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.61324651
66	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.57558366
67	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.56775136
68	Ras signaling pathway_Homo sapiens_hsa04014	0.56775136
69	Alcoholism_Homo sapiens_hsa05034	0.56593610
70	Prion diseases_Homo sapiens_hsa05020	0.56309814
71	Parkinsons disease_Homo sapiens_hsa05012	0.55623661
72	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.55475975
73	Type I diabetes mellitus_Homo sapiens_hsa04940	0.54483537
74	VEGF signaling pathway_Homo sapiens_hsa04370	0.53928384
75	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.51928730
76	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.51428848
77	Endocytosis_Homo sapiens_hsa04144	0.51100790
78	Bile secretion_Homo sapiens_hsa04976	0.50137921
79	Rap1 signaling pathway_Homo sapiens_hsa04015	0.49647838
80	Renal cell carcinoma_Homo sapiens_hsa05211	0.48023760
81	Arginine and proline metabolism_Homo sapiens_hsa00330	0.47468036
82	Glucagon signaling pathway_Homo sapiens_hsa04922	0.44009222
83	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.42684804
84	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.40987243
85	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.40950765
86	Wnt signaling pathway_Homo sapiens_hsa04310	0.39337465
87	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.39256823
88	Hippo signaling pathway_Homo sapiens_hsa04390	0.38505854
89	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.37780781
90	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.35810189
91	Histidine metabolism_Homo sapiens_hsa00340	0.34341902
92	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.33981110
93	Non-small cell lung cancer_Homo sapiens_hsa05223	0.33940316
94	Tight junction_Homo sapiens_hsa04530	0.33781542
95	AMPK signaling pathway_Homo sapiens_hsa04152	0.32677942
96	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.32421040
97	Arginine biosynthesis_Homo sapiens_hsa00220	0.32215876
98	beta-Alanine metabolism_Homo sapiens_hsa00410	0.32062997
99	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.31732476
100	Butanoate metabolism_Homo sapiens_hsa00650	0.30950779
101	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.30901141
102	Ether lipid metabolism_Homo sapiens_hsa00565	0.30527687
103	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.30524405
104	Mineral absorption_Homo sapiens_hsa04978	0.30484583
105	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.29398280
106	Huntingtons disease_Homo sapiens_hsa05016	0.28693144
107	Chemokine signaling pathway_Homo sapiens_hsa04062	0.28155441
108	Insulin signaling pathway_Homo sapiens_hsa04910	0.27943985
109	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.27020028
110	African trypanosomiasis_Homo sapiens_hsa05143	0.26887046
111	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.26621762
112	mTOR signaling pathway_Homo sapiens_hsa04150	0.26523076
113	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.26207722
114	Circadian rhythm_Homo sapiens_hsa04710	0.25767176
115	Protein digestion and absorption_Homo sapiens_hsa04974	0.24870027
116	Endometrial cancer_Homo sapiens_hsa05213	0.24859884
117	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.23059803

SLC22A17

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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