ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	glycosphingolipid catabolic process (GO:0046479)	5.12268645
2	glycolipid catabolic process (GO:0019377)	4.65692130
3	GDP-mannose metabolic process (GO:0019673)	4.40803166
4	oligosaccharide catabolic process (GO:0009313)	4.19236987
5	sperm capacitation (GO:0048240)	4.12280759
6	ceramide catabolic process (GO:0046514)	4.02833057
7	regulation of guanylate cyclase activity (GO:0031282)	3.85405278
8	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	3.83702903
9	peptide catabolic process (GO:0043171)	3.73182179
10	intestinal absorption (GO:0050892)	3.72179471
11	bile acid and bile salt transport (GO:0015721)	3.71498431
12	protein carboxylation (GO:0018214)	3.66749070
13	peptidyl-glutamic acid carboxylation (GO:0017187)	3.66749070
14	sphingolipid catabolic process (GO:0030149)	3.61634289
15	fusion of sperm to egg plasma membrane (GO:0007342)	3.59704538
16	angiotensin maturation (GO:0002003)	3.59598691
17	sulfur amino acid catabolic process (GO:0000098)	3.57302960
18	fat-soluble vitamin biosynthetic process (GO:0042362)	3.55427754
19	membrane lipid catabolic process (GO:0046466)	3.44810035
20	flavonoid metabolic process (GO:0009812)	3.37817290
21	urea metabolic process (GO:0019627)	3.34121310
22	response to acidic pH (GO:0010447)	3.30889266
23	cellular glucuronidation (GO:0052695)	3.29993653
24	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.28570133
25	urea cycle (GO:0000050)	3.28043161
26	glucuronate metabolic process (GO:0019585)	3.18320758
27	uronic acid metabolic process (GO:0006063)	3.18320758
28	sexual reproduction (GO:0019953)	3.15333144
29	response to peptidoglycan (GO:0032494)	3.11980456
30	cellular response to pH (GO:0071467)	3.10526069
31	epoxygenase P450 pathway (GO:0019373)	3.08216027
32	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.05805290
33	positive regulation of lipoprotein lipase activity (GO:0051006)	3.02529781
34	positive regulation of triglyceride lipase activity (GO:0061365)	3.02529781
35	regulation of vitamin metabolic process (GO:0030656)	2.98874245
36	nitrogen cycle metabolic process (GO:0071941)	2.97888147
37	glutathione biosynthetic process (GO:0006750)	2.95530137
38	hyaluronan catabolic process (GO:0030214)	2.95365092
39	amino sugar catabolic process (GO:0046348)	2.89332135
40	L-phenylalanine metabolic process (GO:0006558)	2.87269059
41	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.87269059
42	glycoside metabolic process (GO:0016137)	2.86787500
43	positive regulation of guanylate cyclase activity (GO:0031284)	2.84242105
44	ethanol oxidation (GO:0006069)	2.80948943
45	hormone catabolic process (GO:0042447)	2.77088554
46	regulation of cholesterol homeostasis (GO:2000188)	2.76948339
47	regulation of mononuclear cell migration (GO:0071675)	2.74418953
48	glycosylceramide metabolic process (GO:0006677)	2.72144582
49	nonribosomal peptide biosynthetic process (GO:0019184)	2.71824455
50	regulation of respiratory burst (GO:0060263)	2.70728811
51	neutrophil activation involved in immune response (GO:0002283)	2.68595395
52	ketone body metabolic process (GO:1902224)	2.68561348
53	NADH metabolic process (GO:0006734)	2.67023615
54	adenosine receptor signaling pathway (GO:0001973)	2.66954794
55	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	2.66795742
56	regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	2.65709030
57	endocrine process (GO:0050886)	2.65709030
58	regulation of systemic arterial blood pressure by hormone (GO:0001990)	2.65709030
59	positive regulation of respiratory burst (GO:0060267)	2.64542261
60	sphingomyelin metabolic process (GO:0006684)	2.64132918
61	complement activation, alternative pathway (GO:0006957)	2.62354704
62	cellular response to thyroid hormone stimulus (GO:0097067)	2.62329119
63	renal system process involved in regulation of blood volume (GO:0001977)	2.61296213
64	positive regulation of Cdc42 GTPase activity (GO:0043089)	2.61146446
65	glutathione metabolic process (GO:0006749)	2.58737362
66	N-acetylneuraminate metabolic process (GO:0006054)	2.58321059
67	bile acid metabolic process (GO:0008206)	2.58229308
68	protein retention in ER lumen (GO:0006621)	2.57838601
69	response to thyroid hormone (GO:0097066)	2.57641156
70	cellular ketone body metabolic process (GO:0046950)	2.55569552
71	drug transport (GO:0015893)	2.53339957
72	plasma membrane fusion (GO:0045026)	2.52536210
73	immunoglobulin mediated immune response (GO:0016064)	2.52245754
74	barbed-end actin filament capping (GO:0051016)	2.52082439
75	drug transmembrane transport (GO:0006855)	2.51358640
76	transcytosis (GO:0045056)	2.50901842
77	detection of molecule of bacterial origin (GO:0032490)	2.50787959
78	acrosome reaction (GO:0007340)	2.49892606
79	glomerular filtration (GO:0003094)	2.49560766
80	alkaloid metabolic process (GO:0009820)	2.48877723
81	melanin biosynthetic process (GO:0042438)	2.48453135
82	low-density lipoprotein particle clearance (GO:0034383)	2.47088141
83	negative regulation of interleukin-8 production (GO:0032717)	2.46782252
84	regulation of cGMP biosynthetic process (GO:0030826)	2.46689800
85	fibrinolysis (GO:0042730)	2.45285805
86	renal filtration (GO:0097205)	2.45098848
87	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.44717216
88	response to pH (GO:0009268)	2.43242736
89	positive regulation of pseudopodium assembly (GO:0031274)	2.40859068
90	receptor guanylyl cyclase signaling pathway (GO:0007168)	2.40087494
91	drug metabolic process (GO:0017144)	2.36791407
92	pinocytosis (GO:0006907)	2.35886520
93	sperm motility (GO:0030317)	2.35720894
94	regulation of metalloenzyme activity (GO:0048552)	2.34041988
95	regulation of cholesterol esterification (GO:0010872)	2.33463544
96	mannose metabolic process (GO:0006013)	2.33363199
97	phospholipid efflux (GO:0033700)	2.33215936
98	regulation of cellular pH (GO:0030641)	2.32727800
99	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.32463771
100	negative regulation of blood coagulation (GO:0030195)	2.32326144

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	3.20351014
2	LXR_22292898_ChIP-Seq_THP-1_Human	2.87755437
3	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	2.56989182
4	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.56144378
5	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.53149726
6	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.46271105
7	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.44302409
8	PPARA_22158963_ChIP-Seq_LIVER_Mouse	2.44263817
9	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.41923603
10	VDR_21846776_ChIP-Seq_THP-1_Human	2.41162484
11	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.28109235
12	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.12037743
13	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.11172229
14	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.08467624
15	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.07848739
16	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.94545537
17	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.94070035
18	BCL6_27268052_Chip-Seq_Bcells_Human	1.92551013
19	* RACK7_27058665_Chip-Seq_MCF-7_Human	1.90065076
20	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.88798123
21	BCOR_27268052_Chip-Seq_Bcells_Human	1.88285097
22	VDR_24763502_ChIP-Seq_THP-1_Human	1.87758650
23	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.81947468
24	P68_20966046_ChIP-Seq_HELA_Human	1.70468491
25	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.69696143
26	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.69551821
27	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.65939857
28	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.62360499
29	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.61904203
30	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.61648025
31	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.59704359
32	E2F1_20622854_ChIP-Seq_HELA_Human	1.58736577
33	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.55647732
34	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.54842146
35	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.50056882
36	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.46818645
37	PHF8_20622854_ChIP-Seq_HELA_Human	1.44866144
38	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.44091752
39	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.42360922
40	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.41718542
41	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.41387632
42	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.40220143
43	CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.39115887
44	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.38961135
45	ATF3_27146783_Chip-Seq_COLON_Human	1.38870062
46	CTCF_20526341_ChIP-Seq_ESCs_Human	1.37499192
47	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.37482665
48	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.36533167
49	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.36440907
50	SMC4_20622854_ChIP-Seq_HELA_Human	1.36190277
51	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.34981608
52	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.34869121
53	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.33990579
54	SOX2_20726797_ChIP-Seq_SW620_Human	1.30888178
55	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.30879328
56	SA1_27219007_Chip-Seq_Bcells_Human	1.30599613
57	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.30362311
58	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.29974464
59	GATA6_25053715_ChIP-Seq_YYC3_Human	1.26166585
60	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.23608744
61	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.23495547
62	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.21635326
63	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.21357701
64	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.20818854
65	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.20134767
66	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.19997961
67	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.19715609
68	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.19463622
69	TP63_22573176_ChIP-Seq_HFKS_Human	1.19274885
70	CTCF_27219007_Chip-Seq_Bcells_Human	1.19052163
71	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.18322589
72	* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.17961453
73	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.17859780
74	PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.16020793
75	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.15952738
76	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	1.15764970
77	* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.15534546
78	CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.14215378
79	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.13183391
80	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.12441263
81	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.10973935
82	KLF5_25053715_ChIP-Seq_YYC3_Human	1.09186654
83	P300_27268052_Chip-Seq_Bcells_Human	1.09095050
84	CTCF_21964334_Chip-Seq_Bcells_Human	1.08687475
85	* SPI1_23127762_ChIP-Seq_K562_Human	1.08278051
86	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.07883672
87	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.06702138
88	GATA4_25053715_ChIP-Seq_YYC3_Human	1.06200471
89	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.05329531
90	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.04972134
91	ZNF263_19887448_ChIP-Seq_K562_Human	1.04866440
92	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.04605611
93	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.04362301
94	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.04161280
95	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.02864135
96	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.02322751
97	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.02315067
98	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.01840552
99	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.01563705
100	CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.01407452

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	5.55491609
2	MP0005360_urolithiasis	3.73201124
3	MP0005365_abnormal_bile_salt	3.55969893
4	MP0005058_abnormal_lysosome_morphology	3.37451389
5	MP0009840_abnormal_foam_cell	3.15006991
6	MP0003806_abnormal_nucleotide_metabolis	3.02847839
7	MP0005410_abnormal_fertilization	2.84767445
8	MP0005085_abnormal_gallbladder_physiolo	2.78611058
9	MP0008875_abnormal_xenobiotic_pharmacok	2.34022607
10	MP0005451_abnormal_body_composition	2.31540021
11	MP0003191_abnormal_cellular_cholesterol	2.21589158
12	MP0010234_abnormal_vibrissa_follicle	2.20450703
13	MP0006082_CNS_inflammation	2.10196528
14	MP0005257_abnormal_intraocular_pressure	2.08997623
15	MP0005171_absent_coat_pigmentation	2.05595933
16	MP0003172_abnormal_lysosome_physiology	2.03007934
17	MP0005670_abnormal_white_adipose	2.02941131
18	MP0003303_peritoneal_inflammation	1.90672212
19	MP0001666_abnormal_nutrient_absorption	1.86619506
20	MP0004019_abnormal_vitamin_homeostasis	1.77542119
21	MP0003436_decreased_susceptibility_to	1.76413504
22	MP0009785_altered_susceptibility_to	1.68883305
23	MP0002138_abnormal_hepatobiliary_system	1.65456930
24	MP0002148_abnormal_hypersensitivity_rea	1.58556626
25	MP0005409_darkened_coat_color	1.58156281
26	MP0010155_abnormal_intestine_physiology	1.54610869
27	MP0003724_increased_susceptibility_to	1.51793944
28	MP0003453_abnormal_keratinocyte_physiol	1.44939830
29	MP0002419_abnormal_innate_immunity	1.40454133
30	MP0005083_abnormal_biliary_tract	1.38590226
31	MP0005166_decreased_susceptibility_to	1.38127108
32	MP0004264_abnormal_extraembryonic_tissu	1.37930436
33	MP0003705_abnormal_hypodermis_morpholog	1.32920353
34	MP0003183_abnormal_peptide_metabolism	1.32710692
35	MP0005025_abnormal_response_to	1.31803761
36	MP0009643_abnormal_urine_homeostasis	1.29513547
37	MP0005332_abnormal_amino_acid	1.26030239
38	MP0001756_abnormal_urination	1.25173318
39	MP0000343_altered_response_to	1.23772596
40	MP0008469_abnormal_protein_level	1.22346666
41	MP0010329_abnormal_lipoprotein_level	1.21680717
42	MP0005377_hearing/vestibular/ear_phenot	1.21670584
43	MP0003878_abnormal_ear_physiology	1.21670584
44	MP0005310_abnormal_salivary_gland	1.19267125
45	MP0005408_hypopigmentation	1.17454552
46	MP0002877_abnormal_melanocyte_morpholog	1.16587528
47	MP0001765_abnormal_ion_homeostasis	1.15792623
48	MP0000678_abnormal_parathyroid_gland	1.15366499
49	MP0001663_abnormal_digestive_system	1.15257245
50	MP0005174_abnormal_tail_pigmentation	1.14140328
51	MP0005584_abnormal_enzyme/coenzyme_acti	1.13917051
52	MP0000858_altered_metastatic_potential	1.12849748
53	MP0000609_abnormal_liver_physiology	1.11905722
54	MP0002118_abnormal_lipid_homeostasis	1.11752434
55	MP0001845_abnormal_inflammatory_respons	1.11375361
56	MP0003075_altered_response_to	1.11089056
57	MP0001533_abnormal_skeleton_physiology	1.09897172
58	MP0003868_abnormal_feces_composition	1.08090318
59	MP0003866_abnormal_defecation	1.07939908
60	MP0009764_decreased_sensitivity_to	1.05366369
61	MP0000604_amyloidosis	1.03556039
62	MP0003950_abnormal_plasma_membrane	1.02357281
63	MP0001764_abnormal_homeostasis	1.02134053
64	MP0005319_abnormal_enzyme/_coenzyme	1.01104649
65	MP0002998_abnormal_bone_remodeling	1.00679540
66	MP0000490_abnormal_crypts_of	0.98818343
67	MP0000015_abnormal_ear_pigmentation	0.96659103
68	MP0004782_abnormal_surfactant_physiolog	0.96109156
69	MP0002136_abnormal_kidney_physiology	0.95329496
70	MP0001664_abnormal_digestion	0.93027727
71	MP0005387_immune_system_phenotype	0.92356253
72	MP0001790_abnormal_immune_system	0.92356253
73	MP0002452_abnormal_antigen_presenting	0.90474681
74	MP0001835_abnormal_antigen_presentation	0.89434847
75	MP0005636_abnormal_mineral_homeostasis	0.89355969
76	MP0000371_diluted_coat_color	0.88794658
77	MP0005165_increased_susceptibility_to	0.88379537
78	MP0001873_stomach_inflammation	0.88202389
79	MP0005023_abnormal_wound_healing	0.87949368
80	MP0000685_abnormal_immune_system	0.87437109
81	MP0001853_heart_inflammation	0.87260968
82	MP0005164_abnormal_response_to	0.86314434
83	MP0001661_extended_life_span	0.86238248
84	MP0002132_abnormal_respiratory_system	0.85891274
85	MP0005381_digestive/alimentary_phenotyp	0.84583703
86	MP0003448_altered_tumor_morphology	0.84566971
87	MP0004947_skin_inflammation	0.84334499
88	MP0009333_abnormal_splenocyte_physiolog	0.83449702
89	MP0005330_cardiomyopathy	0.79839144
90	MP0008260_abnormal_autophagy	0.79588390
91	MP0002723_abnormal_immune_serum	0.79536246
92	MP0005000_abnormal_immune_tolerance	0.79175932
93	MP0003252_abnormal_bile_duct	0.78736081
94	MP0000249_abnormal_blood_vessel	0.78523409
95	MP0000372_irregular_coat_pigmentation	0.77040605
96	MP0005666_abnormal_adipose_tissue	0.76446987
97	MP0000751_myopathy	0.73846082
98	MP0003879_abnormal_hair_cell	0.70655062
99	MP0003828_pulmonary_edema	0.70312296
100	MP0003300_gastrointestinal_ulcer	0.68927450

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of glycolipid metabolism (HP:0010969)	4.98868476
2	Abnormality of liposaccharide metabolism (HP:0010968)	4.98868476
3	Abnormality of glycosphingolipid metabolism (HP:0004343)	4.98868476
4	Systemic lupus erythematosus (HP:0002725)	4.67296740
5	Hemorrhage of the eye (HP:0011885)	4.51891208
6	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.69614479
7	Increased cerebral lipofuscin (HP:0011813)	3.39702415
8	Vacuolated lymphocytes (HP:0001922)	3.31325890
9	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.29647864
10	Prolonged partial thromboplastin time (HP:0003645)	3.11574813
11	Joint hemorrhage (HP:0005261)	3.06992615
12	Renal Fanconi syndrome (HP:0001994)	3.01616891
13	Hyperactive renin-angiotensin system (HP:0000841)	3.00176902
14	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.97654967
15	Abnormality of polysaccharide metabolism (HP:0011012)	2.93686731
16	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.93686731
17	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.93686731
18	Dysostosis multiplex (HP:0000943)	2.93512248
19	Mucopolysacchariduria (HP:0008155)	2.86823047
20	Urinary glycosaminoglycan excretion (HP:0003541)	2.86823047
21	Thin bony cortex (HP:0002753)	2.86072336
22	Complement deficiency (HP:0004431)	2.82941856
23	Deep venous thrombosis (HP:0002625)	2.75098274
24	Petechiae (HP:0000967)	2.74425859
25	Malnutrition (HP:0004395)	2.70785664
26	Abnormality of complement system (HP:0005339)	2.70661669
27	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.69210113
28	Glomerulonephritis (HP:0000099)	2.68166240
29	Abnormality of macrophages (HP:0004311)	2.64728657
30	Decreased circulating renin level (HP:0003351)	2.64361866
31	Asymmetric septal hypertrophy (HP:0001670)	2.63836263
32	Axonal loss (HP:0003447)	2.61062556
33	Xanthomatosis (HP:0000991)	2.56568647
34	Abdominal distention (HP:0003270)	2.54468827
35	Enlarged epiphyses (HP:0010580)	2.52420020
36	Mesangial abnormality (HP:0001966)	2.50500743
37	Recurrent gram-negative bacterial infections (HP:0005420)	2.48658746
38	Metabolic alkalosis (HP:0200114)	2.41738172
39	Purpura (HP:0000979)	2.37704964
40	Prolonged neonatal jaundice (HP:0006579)	2.37288736
41	Intrahepatic cholestasis (HP:0001406)	2.36852227
42	Loss of speech (HP:0002371)	2.34979174
43	Myocardial infarction (HP:0001658)	2.34150450
44	Hydroxyprolinuria (HP:0003080)	2.33038253
45	Abnormality of proline metabolism (HP:0010907)	2.33038253
46	Widely patent fontanelles and sutures (HP:0004492)	2.31850284
47	Paraparesis (HP:0002385)	2.31511323
48	Nephritis (HP:0000123)	2.31275771
49	Eczematoid dermatitis (HP:0000976)	2.28851148
50	Conjugated hyperbilirubinemia (HP:0002908)	2.28455539
51	Abnormality of renin-angiotensin system (HP:0000847)	2.26168476
52	Ileus (HP:0002595)	2.24834006
53	Glycosuria (HP:0003076)	2.22919759
54	Abnormality of urine glucose concentration (HP:0011016)	2.22919759
55	Abnormality of chloride homeostasis (HP:0011422)	2.20739834
56	Alkalosis (HP:0001948)	2.19526228
57	Recurrent abscess formation (HP:0002722)	2.16335794
58	Abnormality of the costochondral junction (HP:0000919)	2.16289425
59	Severe visual impairment (HP:0001141)	2.15007021
60	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	2.14546164
61	Increased muscle lipid content (HP:0009058)	2.12809966
62	Congenital sensorineural hearing impairment (HP:0008527)	2.10926141
63	Increased hepatocellular lipid droplets (HP:0006565)	2.10221031
64	Lipid accumulation in hepatocytes (HP:0006561)	2.08263629
65	Recurrent bacterial skin infections (HP:0005406)	2.08244553
66	Protuberant abdomen (HP:0001538)	2.07714067
67	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.06515530
68	Generalized aminoaciduria (HP:0002909)	2.05189876
69	Hypobetalipoproteinemia (HP:0003563)	2.04335952
70	Abnormality of the nasal mucosa (HP:0000433)	2.03251340
71	Progressive neurologic deterioration (HP:0002344)	2.02988394
72	Exertional dyspnea (HP:0002875)	2.02979469
73	Hypolipoproteinemia (HP:0010981)	2.01894344
74	Vertebral compression fractures (HP:0002953)	2.01527029
75	Hypoalphalipoproteinemia (HP:0003233)	2.00871853
76	Increased intramyocellular lipid droplets (HP:0012240)	1.98820113
77	Akinesia (HP:0002304)	1.98778397
78	Hypertriglyceridemia (HP:0002155)	1.97126818
79	Bone pain (HP:0002653)	1.97087774
80	Abnormal urine phosphate concentration (HP:0012599)	1.96242045
81	Abnormality of the intrinsic pathway (HP:0010989)	1.94289127
82	Fat malabsorption (HP:0002630)	1.93904259
83	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.93760205
84	Testicular atrophy (HP:0000029)	1.93304594
85	Choroideremia (HP:0001139)	1.93212877
86	Amyloidosis (HP:0011034)	1.91940718
87	Renal tubular dysfunction (HP:0000124)	1.91535486
88	Hepatosplenomegaly (HP:0001433)	1.88636892
89	Hyperphosphaturia (HP:0003109)	1.87101241
90	Abnormality of pyrimidine metabolism (HP:0004353)	1.85540234
91	Delayed epiphyseal ossification (HP:0002663)	1.84637638
92	Hypophosphatemia (HP:0002148)	1.83748886
93	Attenuation of retinal blood vessels (HP:0007843)	1.83129675
94	Spastic paraparesis (HP:0002313)	1.81958928
95	Disinhibition (HP:0000734)	1.81130960
96	Hyponatremia (HP:0002902)	1.80812848
97	Abnormality of renal resorption (HP:0011038)	1.79644949
98	Nausea (HP:0002018)	1.78552977
99	Increased serum ferritin (HP:0003281)	1.78418677
100	Flattened epiphyses (HP:0003071)	1.77132690

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST1R	8.08829209
2	EPHA2	3.59515229
3	ERN1	3.45363852
4	IRAK3	3.16046171
5	MET	2.94752590
6	TESK1	2.84857997
7	MAPK15	2.44225746
8	ACVR1B	2.37357005
9	BLK	2.34451413
10	TESK2	2.25096371
11	LMTK2	2.15655278
12	DDR2	2.13411184
13	RIPK1	2.08460699
14	INSRR	1.92693875
15	NME2	1.91320760
16	EPHB2	1.85276331
17	TGFBR2	1.78159687
18	MAP3K11	1.74007962
19	MAP3K3	1.55686869
20	SIK1	1.44262472
21	PDPK1	1.41626670
22	PAK4	1.38302645
23	TBK1	1.36815193
24	TRIB3	1.36784246
25	ABL2	1.33910610
26	PRKG2	1.33682384
27	ARAF	1.26910104
28	RIPK4	1.25915632
29	BMX	1.22554999
30	IRAK2	1.17214272
31	TYK2	1.14963476
32	MAP3K2	1.13156906
33	MAP3K12	1.12364370
34	CSK	1.10697175
35	ZAP70	1.09773826
36	PTK6	1.04290319
37	PDK2	1.02659561
38	MATK	1.01095960
39	MAP2K3	0.97953752
40	IRAK4	0.94490125
41	MAP3K1	0.85273644
42	GRK6	0.84246802
43	IKBKB	0.80446982
44	PIM2	0.80126865
45	GRK7	0.79763404
46	PIK3CA	0.77344942
47	PDK1	0.76875442
48	MUSK	0.76122683
49	MAP4K1	0.74005480
50	STK38	0.72330240
51	MAP3K14	0.68601677
52	LIMK1	0.66667897
53	TAOK1	0.61476183
54	TAOK2	0.61176635
55	CSF1R	0.61150338
56	MAP2K6	0.61057562
57	PRPF4B	0.60661456
58	WNK4	0.58727116
59	FGR	0.58614813
60	MYLK	0.58182876
61	IRAK1	0.56753924
62	STK24	0.52995171
63	MOS	0.52352168
64	IKBKE	0.48176710
65	PLK4	0.46134687
66	RPS6KA2	0.44170880
67	LYN	0.42429415
68	MST4	0.38694054
69	MAPK11	0.38473181
70	STK39	0.38080916
71	PRKAA2	0.36607653
72	STK38L	0.34820323
73	CHUK	0.34083045
74	PTK2	0.32728609
75	MAP3K8	0.32541717
76	CDC42BPA	0.32229072
77	MAP2K2	0.31496510
78	PRKCD	0.31157192
79	PAK1	0.30042894
80	EPHB1	0.29120459
81	GRK5	0.28851448
82	SRC	0.28563142
83	MAPKAPK2	0.27734250
84	CDK12	0.27215563
85	SIK3	0.27203274
86	ADRBK1	0.26712181
87	JAK3	0.26402179
88	KDR	0.26309633
89	IGF1R	0.26305291
90	KSR2	0.25646471
91	TRPM7	0.24781201
92	MAP3K13	0.23585547
93	MAP4K2	0.22265556
94	MAPKAPK3	0.21716627
95	FER	0.21243960
96	SMG1	0.20704435
97	CAMK2D	0.20182158
98	ILK	0.19583372
99	CDK6	0.19555594
100	YES1	0.18429401

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Other glycan degradation_Homo sapiens_hsa00511	3.48861088
2	Sulfur metabolism_Homo sapiens_hsa00920	3.29631144
3	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.75164514
4	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.37656230
5	Staphylococcus aureus infection_Homo sapiens_hsa05150	2.29268599
6	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.23477082
7	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.13303266
8	Drug metabolism - other enzymes_Homo sapiens_hsa00983	2.12631775
9	Mineral absorption_Homo sapiens_hsa04978	2.04732992
10	Fructose and mannose metabolism_Homo sapiens_hsa00051	2.00230620
11	Lysosome_Homo sapiens_hsa04142	1.99579698
12	Arginine biosynthesis_Homo sapiens_hsa00220	1.90247985
13	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.89375187
14	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.86639110
15	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.86214979
16	Caffeine metabolism_Homo sapiens_hsa00232	1.82647818
17	PPAR signaling pathway_Homo sapiens_hsa03320	1.80568586
18	Chemical carcinogenesis_Homo sapiens_hsa05204	1.79090897
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.79076205
20	Complement and coagulation cascades_Homo sapiens_hsa04610	1.76448237
21	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.74231637
22	Bile secretion_Homo sapiens_hsa04976	1.71440960
23	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.71356006
24	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.69202286
25	Fat digestion and absorption_Homo sapiens_hsa04975	1.67303492
26	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.66223076
27	Sulfur relay system_Homo sapiens_hsa04122	1.53694800
28	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.52367723
29	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.52113190
30	Retinol metabolism_Homo sapiens_hsa00830	1.50987116
31	Sphingolipid metabolism_Homo sapiens_hsa00600	1.41759006
32	Galactose metabolism_Homo sapiens_hsa00052	1.39562697
33	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.37066000
34	Fatty acid degradation_Homo sapiens_hsa00071	1.36487489
35	Graft-versus-host disease_Homo sapiens_hsa05332	1.33938970
36	Histidine metabolism_Homo sapiens_hsa00340	1.29340356
37	Renin-angiotensin system_Homo sapiens_hsa04614	1.29258907
38	Allograft rejection_Homo sapiens_hsa05330	1.27808884
39	Asthma_Homo sapiens_hsa05310	1.27649867
40	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.23244697
41	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.19167522
42	Nitrogen metabolism_Homo sapiens_hsa00910	1.17160385
43	Leishmaniasis_Homo sapiens_hsa05140	1.14101560
44	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.13996273
45	Phenylalanine metabolism_Homo sapiens_hsa00360	1.13945422
46	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.10524317
47	Glutathione metabolism_Homo sapiens_hsa00480	1.08396648
48	Tyrosine metabolism_Homo sapiens_hsa00350	1.08340294
49	Antigen processing and presentation_Homo sapiens_hsa04612	1.04127593
50	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.04107698
51	Glycerolipid metabolism_Homo sapiens_hsa00561	0.99494488
52	Pertussis_Homo sapiens_hsa05133	0.99130907
53	Rheumatoid arthritis_Homo sapiens_hsa05323	0.97460853
54	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.97048580
55	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.92015344
56	Tuberculosis_Homo sapiens_hsa05152	0.84046509
57	Prion diseases_Homo sapiens_hsa05020	0.82531615
58	Osteoclast differentiation_Homo sapiens_hsa04380	0.80872185
59	Arginine and proline metabolism_Homo sapiens_hsa00330	0.79359036
60	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.75852670
61	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.75377033
62	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.72451627
63	Viral myocarditis_Homo sapiens_hsa05416	0.70912604
64	Type I diabetes mellitus_Homo sapiens_hsa04940	0.70776976
65	Phagosome_Homo sapiens_hsa04145	0.69113527
66	Toxoplasmosis_Homo sapiens_hsa05145	0.67740993
67	Salmonella infection_Homo sapiens_hsa05132	0.65161879
68	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.64761053
69	Influenza A_Homo sapiens_hsa05164	0.64048617
70	Tryptophan metabolism_Homo sapiens_hsa00380	0.62205653
71	Legionellosis_Homo sapiens_hsa05134	0.60414550
72	Pyruvate metabolism_Homo sapiens_hsa00620	0.58724629
73	Peroxisome_Homo sapiens_hsa04146	0.57637275
74	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.56303491
75	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.55748065
76	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.52344242
77	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.51714826
78	Carbon metabolism_Homo sapiens_hsa01200	0.45683114
79	TNF signaling pathway_Homo sapiens_hsa04668	0.45152862
80	Endocytosis_Homo sapiens_hsa04144	0.44456196
81	Vibrio cholerae infection_Homo sapiens_hsa05110	0.44207577
82	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.43407173
83	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.42483999
84	Collecting duct acid secretion_Homo sapiens_hsa04966	0.41974314
85	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.40506819
86	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.38026706
87	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.37933262
88	Fatty acid metabolism_Homo sapiens_hsa01212	0.37024541
89	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.36398967
90	Hepatitis C_Homo sapiens_hsa05160	0.33535529
91	Protein digestion and absorption_Homo sapiens_hsa04974	0.32636326
92	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.31978135
93	Malaria_Homo sapiens_hsa05144	0.31972266
94	Metabolic pathways_Homo sapiens_hsa01100	0.31872104
95	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.29641114
96	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.29425212
97	Linoleic acid metabolism_Homo sapiens_hsa00591	0.28905457
98	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.28445566
99	Pentose phosphate pathway_Homo sapiens_hsa00030	0.27705342
100	Insulin resistance_Homo sapiens_hsa04931	0.26210584

SLC22A18AS

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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