SLC22A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* drug transmembrane transport (GO:0006855)9.30927775
2phosphate ion transport (GO:0006817)8.38378273
3lysine catabolic process (GO:0006554)8.29988541
4lysine metabolic process (GO:0006553)8.29988541
5* drug transport (GO:0015893)8.01002442
6exogenous drug catabolic process (GO:0042738)7.46712673
7drug catabolic process (GO:0042737)7.27344479
8glyoxylate metabolic process (GO:0046487)7.16275348
9* organic cation transport (GO:0015695)6.99125103
10phosphate ion transmembrane transport (GO:0035435)6.93751553
11cysteine metabolic process (GO:0006534)6.91256902
12regulation of apoptotic process involved in morphogenesis (GO:1902337)6.75096959
13nephron tubule formation (GO:0072079)6.40766623
14tricarboxylic acid metabolic process (GO:0072350)6.22771186
15nonribosomal peptide biosynthetic process (GO:0019184)6.19738205
16response to mercury ion (GO:0046689)6.18038882
17regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033395.88108248
18collecting duct development (GO:0072044)5.77290358
19excretion (GO:0007588)5.74372086
20short-chain fatty acid metabolic process (GO:0046459)5.63372687
21regulation of mesenchymal cell apoptotic process (GO:2001053)5.62616084
22aspartate family amino acid catabolic process (GO:0009068)5.60733109
23vitamin D metabolic process (GO:0042359)5.59736890
24glutathione biosynthetic process (GO:0006750)5.58245312
25* quaternary ammonium group transport (GO:0015697)5.50309493
26toxin transport (GO:1901998)5.45021389
27branched-chain amino acid metabolic process (GO:0009081)5.42170475
28renal absorption (GO:0070293)5.40534077
29negative regulation of metanephros development (GO:0072217)5.38102046
30fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.30579313
31trivalent inorganic anion homeostasis (GO:0072506)5.15656976
32phosphate ion homeostasis (GO:0055062)5.15656976
33amino-acid betaine transport (GO:0015838)5.08323701
34carnitine transport (GO:0015879)5.08323701
35metanephric nephron tubule development (GO:0072234)5.06124879
36metanephric tubule development (GO:0072170)5.06124879
37erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.03766661
38L-phenylalanine metabolic process (GO:0006558)5.03766661
39polyol transport (GO:0015791)4.99461541
40valine metabolic process (GO:0006573)4.96418808
41erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.95073653
42L-phenylalanine catabolic process (GO:0006559)4.95073653
43serine family amino acid catabolic process (GO:0009071)4.87623866
44cellular modified amino acid catabolic process (GO:0042219)4.83818679
45proline metabolic process (GO:0006560)4.81752114
46serine family amino acid metabolic process (GO:0009069)4.81136485
47aromatic amino acid family catabolic process (GO:0009074)4.79296399
48glycoside metabolic process (GO:0016137)4.78567028
49mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.78216579
50negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.78188046
51homocysteine metabolic process (GO:0050667)4.74264354
52meiotic chromosome segregation (GO:0045132)4.70486044
53metanephric nephron epithelium development (GO:0072243)4.65438146
54modified amino acid transport (GO:0072337)4.63941160
55tryptophan catabolic process (GO:0006569)4.61630139
56indole-containing compound catabolic process (GO:0042436)4.61630139
57indolalkylamine catabolic process (GO:0046218)4.61630139
58amino-acid betaine metabolic process (GO:0006577)4.53621379
59actin filament depolymerization (GO:0030042)4.51782831
602-oxoglutarate metabolic process (GO:0006103)4.48068148
61peptide biosynthetic process (GO:0043043)4.47754234
62fatty acid beta-oxidation (GO:0006635)4.45794616
63tryptophan metabolic process (GO:0006568)4.40856887
64branched-chain amino acid catabolic process (GO:0009083)4.34252744
65tooth mineralization (GO:0034505)4.31960542
66fructose metabolic process (GO:0006000)4.30301113
67metanephric epithelium development (GO:0072207)4.24657500
68peptide catabolic process (GO:0043171)4.24614499
69nephron tubule development (GO:0072080)4.16998200
70sodium-independent organic anion transport (GO:0043252)4.14719461
71fatty acid oxidation (GO:0019395)4.12606892
72carnitine metabolic process (GO:0009437)4.12379271
73cellular ketone body metabolic process (GO:0046950)4.11450684
74regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.11081523
75oligosaccharide catabolic process (GO:0009313)4.09483270
76lipid oxidation (GO:0034440)4.04846608
77resolution of meiotic recombination intermediates (GO:0000712)4.03542327
78acetyl-CoA metabolic process (GO:0006084)4.03290848
79serine family amino acid biosynthetic process (GO:0009070)4.01668268
80response to phenylpropanoid (GO:0080184)4.01073679
81positive regulation of meiosis (GO:0045836)3.97093890
82positive regulation of glomerulus development (GO:0090193)3.92996950
83NADH metabolic process (GO:0006734)3.87298736
84cardiovascular system development (GO:0072358)3.86586736
85glutathione metabolic process (GO:0006749)3.85657372
86regulation of meiosis I (GO:0060631)3.85136763
87glutamate metabolic process (GO:0006536)3.84010379
88cellular amino acid catabolic process (GO:0009063)3.83580769
89response to parathyroid hormone (GO:0071107)3.80968005
90vitamin transport (GO:0051180)3.78263120
91beta-amyloid metabolic process (GO:0050435)3.76645487
92response to growth hormone (GO:0060416)3.76590311
93activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.70594014
94renal tubule development (GO:0061326)3.69989954
95alpha-amino acid catabolic process (GO:1901606)3.68038541
96fatty acid catabolic process (GO:0009062)3.67691875
97positive regulation of meiotic cell cycle (GO:0051446)3.65525938
98cilium or flagellum-dependent cell motility (GO:0001539)3.60567387
99indole-containing compound metabolic process (GO:0042430)3.60365934
100detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.58822567
101sulfur amino acid catabolic process (GO:0000098)3.58434548
102L-methionine salvage (GO:0071267)3.57368920
103L-methionine biosynthetic process (GO:0071265)3.57368920
104amino acid salvage (GO:0043102)3.57368920
105glutathione derivative metabolic process (GO:1901685)3.56212068
106glutathione derivative biosynthetic process (GO:1901687)3.56212068
107aromatic amino acid family metabolic process (GO:0009072)3.56163848
108drug metabolic process (GO:0017144)3.54619381
109ketone body metabolic process (GO:1902224)3.53800252
110fatty acid elongation (GO:0030497)3.52088258
111pattern specification involved in kidney development (GO:0061004)3.50334191
112organic acid catabolic process (GO:0016054)3.49760557
113carboxylic acid catabolic process (GO:0046395)3.49760557
114nephron tubule morphogenesis (GO:0072078)3.48112790
115nephron epithelium morphogenesis (GO:0072088)3.48112790
116cell differentiation involved in metanephros development (GO:0072202)3.46841048
117monocarboxylic acid catabolic process (GO:0072329)3.45102370
118retinal cone cell development (GO:0046549)3.44501414
119gamma-aminobutyric acid transport (GO:0015812)3.41897759
120nephron epithelium development (GO:0072009)3.35987562
121flavonoid metabolic process (GO:0009812)3.35471120
122tricarboxylic acid cycle (GO:0006099)3.35169599
123benzene-containing compound metabolic process (GO:0042537)3.34426306
124pyrimidine ribonucleoside catabolic process (GO:0046133)3.34216096
125glucuronate metabolic process (GO:0019585)3.33848645
126uronic acid metabolic process (GO:0006063)3.33848645
127succinate metabolic process (GO:0006105)3.32991915
128dicarboxylic acid metabolic process (GO:0043648)3.31984320
129behavioral response to nicotine (GO:0035095)3.31314845
130regulation of stem cell maintenance (GO:2000036)3.30218097
131positive regulation of immune response to tumor cell (GO:0002839)3.29513461
132regulation of immune response to tumor cell (GO:0002837)3.29513461
133regulation of response to tumor cell (GO:0002834)3.29513461
134positive regulation of response to tumor cell (GO:0002836)3.29513461
135inositol metabolic process (GO:0006020)3.28975449
136regulation of hippo signaling (GO:0035330)3.24591776
137bone trabecula formation (GO:0060346)3.24210374
138synaptonemal complex assembly (GO:0007130)3.20463253
139energy homeostasis (GO:0097009)3.19139987
140C4-dicarboxylate transport (GO:0015740)3.18871114
141regulation of branching involved in ureteric bud morphogenesis (GO:0090189)3.11522317
142artery smooth muscle contraction (GO:0014824)3.09484354
143dopamine transport (GO:0015872)3.09007632
144positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.06461701
145negative regulation of kidney development (GO:0090185)3.04683861
146synaptonemal complex organization (GO:0070193)3.04608133
147metanephric mesenchyme development (GO:0072075)3.02844930
148cellular response to ammonium ion (GO:0071242)3.01972830
149response to water (GO:0009415)2.96480767
150tonic smooth muscle contraction (GO:0014820)2.95820661
151positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.94379902
152S-adenosylmethionine metabolic process (GO:0046500)2.92233980
153positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.90753284
154embryonic epithelial tube formation (GO:0001838)2.88253666
155positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.88117327
156fatty acid transmembrane transport (GO:1902001)2.83387139
157inositol phosphate-mediated signaling (GO:0048016)2.80453613
158reciprocal meiotic recombination (GO:0007131)2.80104683
159reciprocal DNA recombination (GO:0035825)2.80104683
160epithelial tube formation (GO:0072175)2.74060455
161negative regulation of telomere maintenance (GO:0032205)2.73704550
162piRNA metabolic process (GO:0034587)2.73200987
163negative regulation of transcription regulatory region DNA binding (GO:2000678)2.72766332
164urogenital system development (GO:0001655)2.68400045
165urate metabolic process (GO:0046415)11.1375871
166aminoglycoside antibiotic metabolic process (GO:0030647)10.8048453

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.41815982
2EZH2_22144423_ChIP-Seq_EOC_Human5.66802549
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.39017954
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.59655824
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.30077164
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.89951290
7ESR1_21235772_ChIP-Seq_MCF-7_Human3.68663489
8HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.97211260
9ZNF274_21170338_ChIP-Seq_K562_Hela2.96620187
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.90891396
11GBX2_23144817_ChIP-Seq_PC3_Human2.87756557
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.69464243
13ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.66888135
14CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.54809059
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.46914849
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.42989936
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.33457980
18AR_21909140_ChIP-Seq_LNCAP_Human2.33387258
19PCGF2_27294783_Chip-Seq_ESCs_Mouse2.27453646
20CDX2_20551321_ChIP-Seq_CACO-2_Human2.25394904
21PCGF2_27294783_Chip-Seq_NPCs_Mouse2.21636124
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.18103883
23CLOCK_20551151_ChIP-Seq_293T_Human2.15710787
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.08599839
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.06984056
26TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.03515835
27POU3F2_20337985_ChIP-ChIP_501MEL_Human2.02798149
28IRF1_19129219_ChIP-ChIP_H3396_Human1.98259884
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96354548
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95874969
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89896570
32FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.88098115
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83013140
34EGR1_23403033_ChIP-Seq_LIVER_Mouse1.81341363
35ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.75726364
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73221652
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.71507424
38SMAD4_21799915_ChIP-Seq_A2780_Human1.70849387
39NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.70602134
40* HNF4A_19822575_ChIP-Seq_HepG2_Human1.64131833
41P300_19829295_ChIP-Seq_ESCs_Human1.63410939
42NANOG_19829295_ChIP-Seq_ESCs_Human1.62151712
43SOX2_19829295_ChIP-Seq_ESCs_Human1.62151712
44SOX2_27498859_Chip-Seq_STOMACH_Mouse1.60675574
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.58442486
46STAT3_23295773_ChIP-Seq_U87_Human1.55363199
47EWS_26573619_Chip-Seq_HEK293_Human1.54814678
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54221266
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53603056
50GATA4_25053715_ChIP-Seq_YYC3_Human1.51282880
51LXR_22292898_ChIP-Seq_THP-1_Human1.51221820
52STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.51112342
53* TCF4_23295773_ChIP-Seq_U87_Human1.48151811
54TCF4_22108803_ChIP-Seq_LS180_Human1.47722758
55ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.47056475
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.45654844
57ER_23166858_ChIP-Seq_MCF-7_Human1.45634778
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.45066977
59* FOXA2_19822575_ChIP-Seq_HepG2_Human1.44009110
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43705328
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43679839
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43563532
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43563532
64FUS_26573619_Chip-Seq_HEK293_Human1.42657287
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41292957
66* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41274095
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41246511
68IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.39450379
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39244311
70AR_25329375_ChIP-Seq_VCAP_Human1.37786090
71BCAT_22108803_ChIP-Seq_LS180_Human1.37637999
72RACK7_27058665_Chip-Seq_MCF-7_Human1.36696253
73FOXO3_23340844_ChIP-Seq_DLD1_Human1.36217769
74VDR_22108803_ChIP-Seq_LS180_Human1.35032224
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.34491268
76RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.34092932
77TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.34043568
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32655136
79* SMAD4_21741376_ChIP-Seq_EPCs_Human1.30997442
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.30332473
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28215159
82SOX2_21211035_ChIP-Seq_LN229_Gbm1.26373407
83TAF15_26573619_Chip-Seq_HEK293_Human1.26210117
84EGR1_19032775_ChIP-ChIP_M12_Human1.25141680
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24860911
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24386675
87* RUNX2_22187159_ChIP-Seq_PCA_Human1.22661868
88NFE2_27457419_Chip-Seq_LIVER_Mouse1.21484098
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21358705
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21131669
91HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20998003
92OCT1_27270436_Chip-Seq_PROSTATE_Human1.20609998
93RNF2_27304074_Chip-Seq_NSC_Mouse1.20535420
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.19739016
95VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.19093909
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18837938
97GATA6_25053715_ChIP-Seq_YYC3_Human1.18440988
98AHR_22903824_ChIP-Seq_MCF-7_Human1.17406514
99TBX20_22328084_ChIP-Seq_HEART_Mouse1.16918670
100TBX20_22080862_ChIP-Seq_HEART_Mouse1.16918670
101KDM2B_26808549_Chip-Seq_REH_Human1.16714258
102PRDM14_20953172_ChIP-Seq_ESCs_Human1.16692866
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.15567063
104ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15181504
105CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14845341
106SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.14238638
107SMAD3_21741376_ChIP-Seq_HESCs_Human1.13815946
108* AR_20517297_ChIP-Seq_VCAP_Human1.13339306
109NANOG_18555785_Chip-Seq_ESCs_Mouse1.13318129
110SALL1_21062744_ChIP-ChIP_HESCs_Human1.10889398
111FOXH1_21741376_ChIP-Seq_ESCs_Human1.10329417
112GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10297135
113CJUN_26792858_Chip-Seq_BT549_Human1.09538792
114CRX_20693478_ChIP-Seq_RETINA_Mouse1.09491079
115SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09360377
116EED_16625203_ChIP-ChIP_MESCs_Mouse1.09098176
117HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08999093
118CBP_20019798_ChIP-Seq_JUKART_Human1.07688448
119IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07688448
120DROSHA_22980978_ChIP-Seq_HELA_Human1.06195602
121EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04813207
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03293926
123FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02423581
124FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02391819
125RXR_22108803_ChIP-Seq_LS180_Human1.02045826
126NANOG_20526341_ChIP-Seq_ESCs_Human1.01992066
127FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01904476
128AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01845145
129EZH2_27304074_Chip-Seq_ESCs_Mouse1.01064966
130EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00818523
131STAT3_18555785_Chip-Seq_ESCs_Mouse1.00174489
132JUN_21703547_ChIP-Seq_K562_Human1.00098688
133* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99924382
134PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99828821
135* TP53_22573176_ChIP-Seq_HFKS_Human0.99462321
136ESR1_20079471_ChIP-ChIP_T-47D_Human0.98933394
137AR_21572438_ChIP-Seq_LNCaP_Human0.98669422
138SOX2_20726797_ChIP-Seq_SW620_Human0.97768897
139SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.97593860
140ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96794413
141ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96302897
142PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95226475
143GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95000730
144PIAS1_25552417_ChIP-Seq_VCAP_Human0.93382942
145SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91918030
146BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90194700
147NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89379643
148SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87411454
149GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.86728053
150EP300_21415370_ChIP-Seq_HL-1_Mouse0.86639622
151GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.86591532
152MYC_19915707_ChIP-ChIP_AK7_Human0.86500562
153CDX2_22108803_ChIP-Seq_LS180_Human0.85876184
154BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.84790312
155SMAD4_21741376_ChIP-Seq_HESCs_Human0.84108390
156ERG_21242973_ChIP-ChIP_JURKAT_Human0.83958230
157RAD21_21589869_ChIP-Seq_MESCs_Mouse0.82330171
158HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.81298250
159RAC3_21632823_ChIP-Seq_H3396_Human0.80871327
160TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80337446
161NANOG_18692474_ChIP-Seq_MEFs_Mouse0.79065212
162TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.78876866
163SMC4_20622854_ChIP-Seq_HELA_Human0.78573046
164WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.78228901
165P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.76714931
166TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.76596746
167TP63_23658742_ChIP-Seq_EP156T_Human0.75835567
168SOX2_18692474_ChIP-Seq_MEFs_Mouse0.73593112
169TAF2_19829295_ChIP-Seq_ESCs_Human0.71857974
170FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.70567508
171SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70476435
172CSB_26484114_Chip-Seq_FIBROBLAST_Human0.70344487
173KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.70137947
174CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.70007743
175TET1_21451524_ChIP-Seq_MESCs_Mouse0.69573094
176CEBPB_22108803_ChIP-Seq_LS180_Human0.68631510
177CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.67977829
178TP63_22573176_ChIP-Seq_HFKS_Human0.67929403
179MTF2_20144788_ChIP-Seq_MESCs_Mouse0.67632092
180TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.66823750
181GATA2_19941826_ChIP-Seq_K562_Human0.66652790
182CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.66625305
183P68_20966046_ChIP-Seq_HELA_Human0.66540001
184P63_26484246_Chip-Seq_KERATINOCYTES_Human0.66195175
185P300_27058665_Chip-Seq_ZR-75-30cells_Human0.66040949
186NRF2_20460467_ChIP-Seq_MEFs_Mouse0.65558810

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.66568561
2MP0004043_abnormal_pH_regulation6.22492960
3MP0002139_abnormal_hepatobiliary_system5.10349553
4MP0004019_abnormal_vitamin_homeostasis5.05143901
5MP0005332_abnormal_amino_acid4.97498540
6MP0002138_abnormal_hepatobiliary_system4.26694030
7MP0009643_abnormal_urine_homeostasis3.96176700
8MP0003195_calcinosis3.79702958
9MP0001765_abnormal_ion_homeostasis3.78452973
10MP0005636_abnormal_mineral_homeostasis3.13700344
11MP0008875_abnormal_xenobiotic_pharmacok3.03552719
12MP0001756_abnormal_urination2.99886544
13MP0005377_hearing/vestibular/ear_phenot2.92326501
14MP0003878_abnormal_ear_physiology2.92326501
15MP0002136_abnormal_kidney_physiology2.91484616
16MP0001958_emphysema2.70861770
17MP0003252_abnormal_bile_duct2.51835683
18MP0005365_abnormal_bile_salt2.34501552
19MP0008872_abnormal_physiological_respon2.28990911
20MP0005085_abnormal_gallbladder_physiolo2.26526539
21MP0005058_abnormal_lysosome_morphology2.24188610
22MP0003186_abnormal_redox_activity1.83550647
23MP0003045_fibrosis1.67074291
24MP0005584_abnormal_enzyme/coenzyme_acti1.66716848
25MP0004885_abnormal_endolymph1.65122289
26MP0000538_abnormal_urinary_bladder1.64667974
27MP0005084_abnormal_gallbladder_morpholo1.62802228
28MP0008961_abnormal_basal_metabolism1.62485075
29MP0008877_abnormal_DNA_methylation1.53778624
30MP0004084_abnormal_cardiac_muscle1.52298394
31MP0003806_abnormal_nucleotide_metabolis1.47112853
32MP0002928_abnormal_bile_duct1.43954467
33MP0002160_abnormal_reproductive_system1.43133402
34MP0003300_gastrointestinal_ulcer1.41830680
35MP0005319_abnormal_enzyme/_coenzyme1.41473221
36MP0002876_abnormal_thyroid_physiology1.32905695
37MP0001270_distended_abdomen1.31443111
38MP0003718_maternal_effect1.30670955
39MP0002837_dystrophic_cardiac_calcinosis1.27307141
40MP0000372_irregular_coat_pigmentation1.26540403
41MP0006036_abnormal_mitochondrial_physio1.26268045
42MP0005451_abnormal_body_composition1.23130688
43MP0006276_abnormal_autonomic_nervous1.22576967
44MP0002168_other_aberrant_phenotype1.22344729
45MP0005670_abnormal_white_adipose1.15406904
46MP0000230_abnormal_systemic_arterial1.13175979
47MP0005551_abnormal_eye_electrophysiolog1.11623785
48MP0001919_abnormal_reproductive_system1.09861815
49MP0004147_increased_porphyrin_level1.07847547
50MP0002135_abnormal_kidney_morphology1.06655649
51MP0005535_abnormal_body_temperature1.06287203
52MP0008775_abnormal_heart_ventricle1.05016740
53MP0002089_abnormal_postnatal_growth/wei1.04501583
54MP0005666_abnormal_adipose_tissue1.02818525
55MP0002896_abnormal_bone_mineralization1.01768186
56MP0001501_abnormal_sleep_pattern1.00750130
57MP0005389_reproductive_system_phenotype0.99829665
58MP0001666_abnormal_nutrient_absorption0.99416095
59MP0001664_abnormal_digestion0.99126118
60MP0002736_abnormal_nociception_after0.98055684
61MP0005645_abnormal_hypothalamus_physiol0.97542255
62MP0001968_abnormal_touch/_nociception0.97006039
63MP0003172_abnormal_lysosome_physiology0.96458193
64MP0004264_abnormal_extraembryonic_tissu0.96117310
65MP0001764_abnormal_homeostasis0.95920007
66MP0003136_yellow_coat_color0.95609407
67MP0003283_abnormal_digestive_organ0.93196157
68MP0003183_abnormal_peptide_metabolism0.90819000
69MP0000427_abnormal_hair_cycle0.89493756
70MP0002118_abnormal_lipid_homeostasis0.89199731
71MP0003191_abnormal_cellular_cholesterol0.89034860
72MP0005410_abnormal_fertilization0.85443774
73MP0010368_abnormal_lymphatic_system0.82551659
74MP0003638_abnormal_response/metabolism_0.81209712
75MP0004233_abnormal_muscle_weight0.80996164
76MP0003950_abnormal_plasma_membrane0.78931822
77MP0003646_muscle_fatigue0.78287550
78MP0001440_abnormal_grooming_behavior0.76289892
79MP0009642_abnormal_blood_homeostasis0.75634748
80MP0001661_extended_life_span0.75559184
81MP0004130_abnormal_muscle_cell0.75409995
82MP0000747_muscle_weakness0.74920584
83MP0010234_abnormal_vibrissa_follicle0.74524278
84MP0002272_abnormal_nervous_system0.74257047
85MP0009745_abnormal_behavioral_response0.70655305
86MP0000049_abnormal_middle_ear0.70181356
87MP0002796_impaired_skin_barrier0.69613008
88MP0005220_abnormal_exocrine_pancreas0.69146494
89MP0009764_decreased_sensitivity_to0.67134749
90MP0000371_diluted_coat_color0.65597501
91MP0001486_abnormal_startle_reflex0.64791863
92MP0001485_abnormal_pinna_reflex0.64592654
93MP0000609_abnormal_liver_physiology0.64522557
94MP0005647_abnormal_sex_gland0.63544247
95MP0010329_abnormal_lipoprotein_level0.63200379
96MP0005395_other_phenotype0.61332727
97MP0003879_abnormal_hair_cell0.61020829
98MP0004215_abnormal_myocardial_fiber0.56794147
99MP0002735_abnormal_chemical_nociception0.55785728
100MP0002115_abnormal_skeleton_extremities0.54260601
101MP0000598_abnormal_liver_morphology0.54219403
102MP0008469_abnormal_protein_level0.54020171
103MP0000678_abnormal_parathyroid_gland0.53969464
104MP0003329_amyloid_beta_deposits0.53533634
105MP0000026_abnormal_inner_ear0.53351111
106MP0005646_abnormal_pituitary_gland0.53302578
107MP0003959_abnormal_lean_body0.53195297
108MP0005501_abnormal_skin_physiology0.53075219
109MP0001324_abnormal_eye_pigmentation0.52944559
110MP0000631_abnormal_neuroendocrine_gland0.52739757
111MP0005195_abnormal_posterior_eye0.51830556
112MP0005408_hypopigmentation0.50465434
113MP0002078_abnormal_glucose_homeostasis0.48762140
114MP0002572_abnormal_emotion/affect_behav0.48031867
115MP0004036_abnormal_muscle_relaxation0.47526345
116MP0005503_abnormal_tendon_morphology0.47144057
117MP0006035_abnormal_mitochondrial_morpho0.47079224
118MP0003795_abnormal_bone_structure0.46820666
119MP0002234_abnormal_pharynx_morphology0.46773637
120MP0002210_abnormal_sex_determination0.46744104
121MP0002909_abnormal_adrenal_gland0.46255487
122MP0004742_abnormal_vestibular_system0.45330696
123MP0003953_abnormal_hormone_level0.45133969
124MP0002998_abnormal_bone_remodeling0.44756655
125MP0003632_abnormal_nervous_system0.44751920
126MP0005375_adipose_tissue_phenotype0.44554233
127MP0005266_abnormal_metabolism0.44404771
128MP0005165_increased_susceptibility_to0.43052364
129MP0010386_abnormal_urinary_bladder0.42616666
130MP0003698_abnormal_male_reproductive0.42401287
131MP0001970_abnormal_pain_threshold0.42221516
132MP0002069_abnormal_eating/drinking_beha0.41251555
133MP0000163_abnormal_cartilage_morphology0.40946384
134MP0004272_abnormal_basement_membrane0.38895830
135MP0002098_abnormal_vibrissa_morphology0.37576650
136MP0009672_abnormal_birth_weight0.36348782
137MP0004858_abnormal_nervous_system0.35786070
138MP0003221_abnormal_cardiomyocyte_apopto0.33733156
139MP0003724_increased_susceptibility_to0.33307280
140MP0001663_abnormal_digestive_system0.32944577
141MP0004484_altered_response_of0.32234175
142MP0001963_abnormal_hearing_physiology0.30968127
143MP0001731_abnormal_postnatal_growth0.30646690
144MP0001177_atelectasis0.29988872
145MP0005167_abnormal_blood-brain_barrier0.29851923
146MP0005083_abnormal_biliary_tract0.28489799
147MP0009780_abnormal_chondrocyte_physiolo0.28270628
148MP0002971_abnormal_brown_adipose0.27303186
149MP0002113_abnormal_skeleton_development0.25283718
150MP0000534_abnormal_ureter_morphology0.24011721

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)7.40220406
2Gout (HP:0001997)6.98480508
3Metabolic alkalosis (HP:0200114)6.97413731
4Hypokalemic alkalosis (HP:0001949)6.95962275
5Hypomagnesemia (HP:0002917)6.66350784
6Hyperactive renin-angiotensin system (HP:0000841)6.45555195
7Polyuria (HP:0000103)6.38053493
8Abnormality of chloride homeostasis (HP:0011422)6.02677727
9Abnormal urine output (HP:0012590)5.99580050
10Abnormality of renal excretion (HP:0011036)5.78011817
11Abnormality of magnesium homeostasis (HP:0004921)5.64733755
12Proximal tubulopathy (HP:0000114)5.58654453
13Polydipsia (HP:0001959)5.16293574
14Abnormal drinking behavior (HP:0030082)5.16293574
15Hyperuricemia (HP:0002149)5.03180392
16Increased purine levels (HP:0004368)5.03180392
17Hyperglycinuria (HP:0003108)4.68159511
18Abnormality of glutamine family amino acid metabolism (HP:0010902)4.64606494
19Abnormality of renin-angiotensin system (HP:0000847)4.59681666
20Alkalosis (HP:0001948)4.59227574
21Tetany (HP:0001281)4.56860228
22Abnormality of purine metabolism (HP:0004352)4.56838034
23Renal salt wasting (HP:0000127)4.50685439
24Hyperaldosteronism (HP:0000859)4.43349219
25Generalized aminoaciduria (HP:0002909)4.34203349
26Hypercalciuria (HP:0002150)4.07677354
27Unilateral renal agenesis (HP:0000122)3.96146497
28Abnormality of glycine metabolism (HP:0010895)3.87699209
29Abnormality of serine family amino acid metabolism (HP:0010894)3.87699209
30Glycosuria (HP:0003076)3.81987266
31Abnormality of urine glucose concentration (HP:0011016)3.81987266
32Ketoacidosis (HP:0001993)3.77189611
33Aplasia/Hypoplasia of the fovea (HP:0008060)3.67693884
34Hypoplasia of the fovea (HP:0007750)3.67693884
35Renal tubular acidosis (HP:0001947)3.59707970
36Hypokalemia (HP:0002900)3.51953981
37Hyperphosphaturia (HP:0003109)3.41532608
38Abnormality of nucleobase metabolism (HP:0010932)3.34885268
39Ketosis (HP:0001946)3.34398491
40Delayed epiphyseal ossification (HP:0002663)3.27108906
41Abnormal urine phosphate concentration (HP:0012599)3.19942374
42Abnormality of proline metabolism (HP:0010907)2.99368032
43Hydroxyprolinuria (HP:0003080)2.99368032
44Nephrocalcinosis (HP:0000121)2.98092187
45Abnormality of potassium homeostasis (HP:0011042)2.97405724
46Abnormality of the fovea (HP:0000493)2.90718773
47Large eyes (HP:0001090)2.90569975
48Nephrolithiasis (HP:0000787)2.88486292
49Hypophosphatemia (HP:0002148)2.80115653
50Delayed CNS myelination (HP:0002188)2.77819949
51Vascular calcification (HP:0004934)2.76817692
52Conjugated hyperbilirubinemia (HP:0002908)2.76662746
53Abnormality of fatty-acid metabolism (HP:0004359)2.75939327
54Hyperglycinemia (HP:0002154)2.74352448
55Abnormality of aspartate family amino acid metabolism (HP:0010899)2.73867712
56Vacuolated lymphocytes (HP:0001922)2.63930741
57Metaphyseal cupping (HP:0003021)2.62798073
58Abnormality of macular pigmentation (HP:0008002)2.62226164
59Rickets (HP:0002748)2.61989657
60Bilateral microphthalmos (HP:0007633)2.56073569
61Aplasia/Hypoplasia of the macula (HP:0008059)2.54245452
62Widely patent fontanelles and sutures (HP:0004492)2.49832163
63Abnormality of dicarboxylic acid metabolism (HP:0010995)2.47848172
64Dicarboxylic aciduria (HP:0003215)2.47848172
65Cardiovascular calcification (HP:0011915)2.47617437
66Dehydration (HP:0001944)2.43042783
67Hyperammonemia (HP:0001987)2.42162436
68Nephrogenic diabetes insipidus (HP:0009806)2.37939921
69Aplasia/Hypoplasia affecting the retina (HP:0008061)2.37475022
70Enlarged kidneys (HP:0000105)2.32734484
71Confusion (HP:0001289)2.32730641
72Abnormal enzyme/coenzyme activity (HP:0012379)2.32502677
73Abnormality of renal resorption (HP:0011038)2.30971674
74Abnormality of the renal medulla (HP:0100957)2.30808205
75Metabolic acidosis (HP:0001942)2.30739903
76Vomiting (HP:0002013)2.28069401
77Abnormality of sodium homeostasis (HP:0010931)2.26215326
78Abnormality of alkaline phosphatase activity (HP:0004379)2.26104814
79Hyponatremia (HP:0002902)2.26044465
80Renal tubular dysfunction (HP:0000124)2.22499305
81Abnormality of aromatic amino acid family metabolism (HP:0004338)2.22083587
82Malnutrition (HP:0004395)2.21042680
83Thin bony cortex (HP:0002753)2.20996963
84Methylmalonic aciduria (HP:0012120)2.17639240
85Abnormal tarsal ossification (HP:0008369)2.13646905
86Pancreatic cysts (HP:0001737)2.12040912
87Abnormality of the renal cortex (HP:0011035)2.11038932
88Lethargy (HP:0001254)2.06276042
89Abnormality of sulfur amino acid metabolism (HP:0004339)2.04889425
90Generalized muscle weakness (HP:0003324)2.03137157
91Adrenal overactivity (HP:0002717)2.00787585
92Bilateral sensorineural hearing impairment (HP:0008619)2.00307583
93Chorioretinal atrophy (HP:0000533)1.98641934
94Tubulointerstitial fibrosis (HP:0005576)1.97859998
95Fused cervical vertebrae (HP:0002949)1.96486721
96Facial shape deformation (HP:0011334)1.95410672
97Potter facies (HP:0002009)1.95410672
98Lymphangioma (HP:0100764)1.93689637
99Bicornuate uterus (HP:0000813)1.91243083
100Sensorimotor neuropathy (HP:0007141)1.90370509
101Tubular atrophy (HP:0000092)1.88019948
102Abnormality of the costochondral junction (HP:0000919)1.86677849
103Congenital stationary night blindness (HP:0007642)1.86148691
104Metaphyseal irregularity (HP:0003025)1.86000319
105Chondrocalcinosis (HP:0000934)1.84988642
106Elevated alkaline phosphatase (HP:0003155)1.81228778
107Nausea (HP:0002018)1.81110057
108Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.80868084
109Irritability (HP:0000737)1.80607641
110Hypoplasia of the uterus (HP:0000013)1.77463391
111Decreased circulating renin level (HP:0003351)1.77455515
112Metaphyseal dysplasia (HP:0100255)1.75649730
113Progressive inability to walk (HP:0002505)1.75538583
114Focal segmental glomerulosclerosis (HP:0000097)1.74025243
115Abnormality of Sharpey fibers (HP:0100685)1.72561480
116Late onset (HP:0003584)1.70792608
117Abnormality of serum amino acid levels (HP:0003112)1.70613195
118Neonatal onset (HP:0003623)1.69120681
119Tachypnea (HP:0002789)1.69083342
120Abnormality of carpal bone ossification (HP:0006257)1.68908590
121Glomerulosclerosis (HP:0000096)1.68494338
122Tubulointerstitial abnormality (HP:0001969)1.67311707
123Type II lissencephaly (HP:0007260)1.54036039
124Hypotension (HP:0002615)1.51262046
125Stage 5 chronic kidney disease (HP:0003774)1.51196936
126Aplasia cutis congenita (HP:0001057)1.49348324
127Cystic liver disease (HP:0006706)1.49119439
128Inability to walk (HP:0002540)1.44396443
129Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.43643048
130Aplasia/hypoplasia of the uterus (HP:0008684)1.41289714
1313-Methylglutaconic aciduria (HP:0003535)1.39912908
132Hypophosphatemic rickets (HP:0004912)1.38697170
133Intrahepatic cholestasis (HP:0001406)1.35873259
134Lissencephaly (HP:0001339)1.32296645
135Hypothermia (HP:0002045)1.29796309
136Mixed hearing impairment (HP:0000410)1.27729366
137Gaze-evoked nystagmus (HP:0000640)1.26510674
138Hip dysplasia (HP:0001385)1.25797891
139Congenital hepatic fibrosis (HP:0002612)1.24575113
140CNS hypomyelination (HP:0003429)1.24043474
141Decreased central vision (HP:0007663)1.20708135
142Abnormality of midbrain morphology (HP:0002418)1.20648130

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK49.19160256
2WNK37.77209631
3OXSR17.23387394
4STK394.38918463
5BCKDK3.28212093
6STK38L2.74753852
7RIPK42.53545689
8NEK12.11735429
9WNK12.11450681
10PDK42.08789825
11PDK32.08789825
12TLK11.96905550
13BMPR21.94064959
14SGK4941.83808366
15SGK2231.83808366
16BMPR1B1.81892665
17SIK31.62255477
18ADRBK21.52675600
19SIK21.51134808
20STK381.43414493
21PDK21.41191878
22MST1R1.28521618
23MST41.21986214
24GRK11.14654021
25DAPK21.10540625
26FGFR41.06779021
27LRRK21.03558119
28NEK20.97560430
29SGK30.95542997
30PINK10.94700369
31ACVR1B0.92741825
32SGK20.92146345
33FLT30.91383416
34GRK60.89335697
35STK30.89021200
36ERBB20.88814314
37SIK10.84745434
38TRPM70.82276944
39EPHB10.82129892
40BRSK20.79580809
41GSK3A0.76063546
42MARK30.75692371
43TGFBR10.73137201
44BCR0.71410416
45TAOK30.71276445
46MAP4K20.68032068
47MAPKAPK30.67239406
48DYRK1B0.65131501
49MAP3K70.64224797
50PIK3CA0.63939580
51PTK20.61566123
52SGK10.60704879
53PRKCE0.60410117
54MAP3K30.58903728
55TXK0.58040736
56TIE10.57143278
57MAPKAPK50.56382975
58ADRBK10.56342752
59NUAK10.53923717
60TGFBR20.52953146
61ABL20.52458283
62MELK0.51877736
63PRKAA10.49362019
64TRIM280.48641394
65PAK40.48635012
66MAPK110.47679909
67PDPK10.46173155
68MATK0.45369520
69ERN10.44811860
70TRIB30.44716958
71MAPK130.43731833
72PTK60.42926108
73INSRR0.42900276
74PAK30.39685416
75CSNK1A10.39674248
76ZAK0.37417509
77STK100.36311762
78PRKCI0.35973739
79MET0.35931925
80PRKAA20.35623696
81RIPK10.33851943
82PRKD20.32738667
83MAP3K40.32535551
84FRK0.32271349
85MAP3K20.31700611
86PRKCZ0.31558491
87PDK10.30866139
88PTK2B0.30830043
89FER0.30799867
90TEC0.29158263
91MYLK0.28938724
92CAMK2A0.28927014
93STK110.28580194
94NME20.27428226
95CAMK10.26694873
96MAP3K90.26564180
97NTRK10.25690474
98IRAK20.24368097
99PRKCD0.23226893
100STK240.21203413
101LATS10.21172989
102MAPK150.21079680
103MAP2K60.20341837
104MAP3K140.20132770
105PRKCH0.19967519
106PRKACG0.19317775
107KIT0.18718691
108ERBB40.17962839
109HIPK20.17494246
110TAF10.16572787
111MINK10.16406673
112DYRK1A0.16350679
113GRK70.15967170
114AKT20.15677644
115NLK0.15257360
116GRK50.14867173
117PRKCA0.14309957
118PRKCB0.13597990
119NEK60.13090264
120BMX0.13077073
121JAK20.12844974
122IRAK30.12763914
123EEF2K0.12383606
124BTK0.11748619
125PIM10.11591344
126PRKACA0.11520942
127MAPK70.10954673
128MAP2K10.10894018
129DYRK20.10586305
130SCYL20.10289377
131EPHA40.09900324
132VRK20.09483410
133ROCK10.09143041
134NTRK30.08997490
135MAP2K70.08981366
136PKN10.08595280
137IRAK10.08467239
138SYK0.08351531
139MAP2K40.08152876
140INSR0.07839920
141MAP2K30.07498691
142PRKCG0.06462083
143PRKD30.05936816
144MAPK120.05499426
145PRKCQ0.05003049
146NME10.04384959
147SRC0.04213578
148ITK0.03241573
149MAP3K110.02916399
150IGF1R0.01660661
151CAMK40.01585442
152MTOR0.01552865
153CSK0.00805270
154NEK90.00662843
155PDGFRA-0.0191824
156ABL1-0.0177388
157CAMK1G-0.0135650
158PRKACB-0.0115685
159PIK3CG-0.0113444
160MAPK4-0.0033430
161RPS6KA3-0.0018982

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.05778868
2Butanoate metabolism_Homo sapiens_hsa006503.88194860
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.53051964
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.43772952
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.35480407
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.16860385
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.11849723
8Propanoate metabolism_Homo sapiens_hsa006403.05946862
9Pentose and glucuronate interconversions_Homo sapiens_hsa000403.01692870
10Olfactory transduction_Homo sapiens_hsa047402.66571996
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.59134405
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.52625622
13Peroxisome_Homo sapiens_hsa041462.50408859
14Pyruvate metabolism_Homo sapiens_hsa006202.46590853
15Fatty acid degradation_Homo sapiens_hsa000712.30811447
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.25625049
17Tryptophan metabolism_Homo sapiens_hsa003802.18998459
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.12659491
19Collecting duct acid secretion_Homo sapiens_hsa049662.10484535
20Vitamin digestion and absorption_Homo sapiens_hsa049772.05166553
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.02470391
22Linoleic acid metabolism_Homo sapiens_hsa005911.97830525
23beta-Alanine metabolism_Homo sapiens_hsa004101.89326847
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.89226578
25Sulfur metabolism_Homo sapiens_hsa009201.82680684
26Fatty acid metabolism_Homo sapiens_hsa012121.74459113
27Carbon metabolism_Homo sapiens_hsa012001.64593442
28Glutathione metabolism_Homo sapiens_hsa004801.59992388
29Bile secretion_Homo sapiens_hsa049761.59834823
30Ether lipid metabolism_Homo sapiens_hsa005651.58343741
31Phototransduction_Homo sapiens_hsa047441.58185220
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.57315203
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.57208165
34Caffeine metabolism_Homo sapiens_hsa002321.56448329
35Arginine and proline metabolism_Homo sapiens_hsa003301.46771139
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.32520452
37Other glycan degradation_Homo sapiens_hsa005111.31149403
38Lysine degradation_Homo sapiens_hsa003101.25735927
39Circadian rhythm_Homo sapiens_hsa047101.22870096
40Protein digestion and absorption_Homo sapiens_hsa049741.21250137
41Starch and sucrose metabolism_Homo sapiens_hsa005001.21219591
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.19189609
43Mineral absorption_Homo sapiens_hsa049781.17720625
44PPAR signaling pathway_Homo sapiens_hsa033201.16814732
45Arginine biosynthesis_Homo sapiens_hsa002201.15621730
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.11096869
47Histidine metabolism_Homo sapiens_hsa003401.08159265
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07272715
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05568562
50Basal transcription factors_Homo sapiens_hsa030221.05404355
51Selenocompound metabolism_Homo sapiens_hsa004501.05397284
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05097082
53Nitrogen metabolism_Homo sapiens_hsa009101.00967162
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95755068
55Biosynthesis of amino acids_Homo sapiens_hsa012300.94468297
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93390821
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92993888
58Glycerolipid metabolism_Homo sapiens_hsa005610.91833859
59Salivary secretion_Homo sapiens_hsa049700.91780165
60Long-term depression_Homo sapiens_hsa047300.91082253
61TGF-beta signaling pathway_Homo sapiens_hsa043500.90518596
62Phenylalanine metabolism_Homo sapiens_hsa003600.89199884
63Folate biosynthesis_Homo sapiens_hsa007900.88418167
64Morphine addiction_Homo sapiens_hsa050320.88280119
65Ovarian steroidogenesis_Homo sapiens_hsa049130.85560264
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83535208
67Glutamatergic synapse_Homo sapiens_hsa047240.81755125
68Fructose and mannose metabolism_Homo sapiens_hsa000510.80079426
69GABAergic synapse_Homo sapiens_hsa047270.77118747
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.74336964
71Oxidative phosphorylation_Homo sapiens_hsa001900.72814878
72Insulin secretion_Homo sapiens_hsa049110.72803448
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.68390809
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.68218885
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.67904781
76Serotonergic synapse_Homo sapiens_hsa047260.67412765
77Nicotine addiction_Homo sapiens_hsa050330.66510961
78Circadian entrainment_Homo sapiens_hsa047130.66242199
79Fatty acid elongation_Homo sapiens_hsa000620.65628121
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.65384579
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65251541
82Lysosome_Homo sapiens_hsa041420.63880846
83African trypanosomiasis_Homo sapiens_hsa051430.63570242
84Taste transduction_Homo sapiens_hsa047420.63023009
85Pentose phosphate pathway_Homo sapiens_hsa000300.61255738
86Renin-angiotensin system_Homo sapiens_hsa046140.59894579
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.59497810
88Chemical carcinogenesis_Homo sapiens_hsa052040.56991937
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53895573
90Thyroid hormone synthesis_Homo sapiens_hsa049180.53848345
91Metabolic pathways_Homo sapiens_hsa011000.53366405
92Regulation of autophagy_Homo sapiens_hsa041400.53180492
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53177014
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52273711
95Retinol metabolism_Homo sapiens_hsa008300.44276026
96Gastric acid secretion_Homo sapiens_hsa049710.44213102
97Calcium signaling pathway_Homo sapiens_hsa040200.41216628
98Parkinsons disease_Homo sapiens_hsa050120.40302227
99Arachidonic acid metabolism_Homo sapiens_hsa005900.39112313
100Steroid biosynthesis_Homo sapiens_hsa001000.34827298
101Vibrio cholerae infection_Homo sapiens_hsa051100.33937335
102Pancreatic secretion_Homo sapiens_hsa049720.32435055
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32225105
104Dorso-ventral axis formation_Homo sapiens_hsa043200.31204139
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30020438
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27819334
107Tyrosine metabolism_Homo sapiens_hsa003500.26926530
108Synaptic vesicle cycle_Homo sapiens_hsa047210.26316005
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26174536
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26046642
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.25269606
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24518006
113Oxytocin signaling pathway_Homo sapiens_hsa049210.24177916
114Sulfur relay system_Homo sapiens_hsa041220.23910104
115Renin secretion_Homo sapiens_hsa049240.23214775
116Hippo signaling pathway_Homo sapiens_hsa043900.22413380
117ABC transporters_Homo sapiens_hsa020100.21484805
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21041985
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.19320569
120Sphingolipid metabolism_Homo sapiens_hsa006000.15623310
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.14623388
122Cardiac muscle contraction_Homo sapiens_hsa042600.12853405
123Alzheimers disease_Homo sapiens_hsa050100.10188191
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.10069798
125Insulin resistance_Homo sapiens_hsa049310.07930601
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.06790218
127Galactose metabolism_Homo sapiens_hsa000520.06153919
128Inositol phosphate metabolism_Homo sapiens_hsa005620.03896866
129Rheumatoid arthritis_Homo sapiens_hsa053230.03189083
130alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.01388284
131AMPK signaling pathway_Homo sapiens_hsa041520.00919862
132Huntingtons disease_Homo sapiens_hsa050160.00745194
133Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.1015512
134Bladder cancer_Homo sapiens_hsa05219-0.0896286
135* Choline metabolism in cancer_Homo sapiens_hsa05231-0.0815933
136One carbon pool by folate_Homo sapiens_hsa00670-0.0475099
137Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0462404
138Glucagon signaling pathway_Homo sapiens_hsa04922-0.0409061

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