SLC22A20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SLC22A20 belongs to a large family of transmembrane proteins that function as uniporters, symporters, and antiporters to transport organic ions across cell membranes (Jacobsson et al., 2007 [PubMed 17714910]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sensory perception of chemical stimulus (GO:0007606)7.57533654
2chemosensory behavior (GO:0007635)7.21480558
3mitotic metaphase plate congression (GO:0007080)6.96436226
4vitamin transmembrane transport (GO:0035461)6.09614797
5purine nucleobase biosynthetic process (GO:0009113)5.63340523
6regulation of spindle organization (GO:0090224)5.49233352
7regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.31321190
8ribosome assembly (GO:0042255)5.29820190
9metaphase plate congression (GO:0051310)5.21672402
10nucleobase biosynthetic process (GO:0046112)4.89939823
11intestinal epithelial cell development (GO:0060576)4.86895625
12positive regulation of chromosome segregation (GO:0051984)4.59290781
13rRNA modification (GO:0000154)4.57670276
14regulation of hippo signaling (GO:0035330)4.48876776
15snRNA transcription (GO:0009301)4.48099149
16lung-associated mesenchyme development (GO:0060484)4.47856932
17DNA replication checkpoint (GO:0000076)4.45643484
18ribosome biogenesis (GO:0042254)4.43605055
19termination of RNA polymerase III transcription (GO:0006386)4.33922523
20transcription elongation from RNA polymerase III promoter (GO:0006385)4.33922523
21folic acid transport (GO:0015884)4.30460721
22sphingoid metabolic process (GO:0046519)4.29994886
23folic acid metabolic process (GO:0046655)4.26515212
24tachykinin receptor signaling pathway (GO:0007217)4.25258404
25regulation of mitotic spindle organization (GO:0060236)4.20795134
26intestinal cholesterol absorption (GO:0030299)4.17134004
27protein localization to kinetochore (GO:0034501)4.15492772
28mannose metabolic process (GO:0006013)4.15319510
29tryptophan catabolic process (GO:0006569)4.14991882
30indole-containing compound catabolic process (GO:0042436)4.14991882
31indolalkylamine catabolic process (GO:0046218)4.14991882
32establishment of chromosome localization (GO:0051303)4.10706115
33regulation of exit from mitosis (GO:0007096)4.08471746
34transcription from RNA polymerase I promoter (GO:0006360)4.04101502
35sphingosine metabolic process (GO:0006670)3.99541269
36one-carbon compound transport (GO:0019755)3.98461065
37meiosis I (GO:0007127)3.97605181
38termination of RNA polymerase I transcription (GO:0006363)3.96806016
39regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.96039334
40transcription elongation from RNA polymerase I promoter (GO:0006362)3.95607943
41indolalkylamine metabolic process (GO:0006586)3.89675490
42regulation of posttranscriptional gene silencing (GO:0060147)3.89292519
43regulation of gene silencing by miRNA (GO:0060964)3.89292519
44regulation of gene silencing by RNA (GO:0060966)3.89292519
45NAD biosynthetic process (GO:0009435)3.87712253
46CDP-diacylglycerol metabolic process (GO:0046341)3.83499478
47protein localization to chromosome, centromeric region (GO:0071459)3.81575403
48detection of light stimulus involved in sensory perception (GO:0050962)3.80122408
49detection of light stimulus involved in visual perception (GO:0050908)3.80122408
50DNA methylation involved in gamete generation (GO:0043046)3.79170680
51positive regulation of developmental pigmentation (GO:0048087)3.76544199
527-methylguanosine mRNA capping (GO:0006370)3.75856527
53transcription initiation from RNA polymerase I promoter (GO:0006361)3.74791941
54regulation of female gonad development (GO:2000194)3.68779838
55protein localization to cilium (GO:0061512)3.64586208
56RNA capping (GO:0036260)3.63167947
577-methylguanosine RNA capping (GO:0009452)3.63167947
58attachment of spindle microtubules to kinetochore (GO:0008608)3.60113851
59tryptophan metabolic process (GO:0006568)3.58548661
60antibacterial humoral response (GO:0019731)3.55642636
61blastocyst development (GO:0001824)3.54197218
62protein K11-linked deubiquitination (GO:0035871)3.54040107
63diol metabolic process (GO:0034311)3.53902356
64histone H3-K4 trimethylation (GO:0080182)3.53295233
65protein K48-linked deubiquitination (GO:0071108)3.52932797
66regulation of G0 to G1 transition (GO:0070316)3.52571234
67regulation of DNA methylation (GO:0044030)3.52560375
68histone H3-K9 methylation (GO:0051567)3.50143621
69GMP metabolic process (GO:0046037)3.47060910
70negative regulation of fibroblast apoptotic process (GO:2000270)3.45239957
71motile cilium assembly (GO:0044458)3.43181625
72positive regulation of uterine smooth muscle contraction (GO:0070474)3.39409360
73inner cell mass cell proliferation (GO:0001833)3.38540848
74fucose catabolic process (GO:0019317)3.38341502
75L-fucose metabolic process (GO:0042354)3.38341502
76L-fucose catabolic process (GO:0042355)3.38341502
77negative regulation of cAMP-mediated signaling (GO:0043951)3.37697749
78male meiosis I (GO:0007141)3.37656131
79CENP-A containing nucleosome assembly (GO:0034080)3.36761173
80transcription elongation from RNA polymerase II promoter (GO:0006368)3.36051397
81positive regulation of CREB transcription factor activity (GO:0032793)3.35797225
82regulation of chromosome segregation (GO:0051983)3.35726116
83antimicrobial humoral response (GO:0019730)3.32922584
84rRNA methylation (GO:0031167)3.31530195
85guanosine-containing compound biosynthetic process (GO:1901070)3.30418710
86DNA-templated transcription, elongation (GO:0006354)3.30196647
87synaptonemal complex assembly (GO:0007130)3.30038685
88spindle checkpoint (GO:0031577)3.29498386
89anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.28476185
90protein K6-linked ubiquitination (GO:0085020)3.28316387
91purinergic nucleotide receptor signaling pathway (GO:0035590)3.26739460
92regulation of translation in response to stress (GO:0043555)3.26738806
93NADH metabolic process (GO:0006734)3.24350189
94histone exchange (GO:0043486)3.23789203
95maturation of 5.8S rRNA (GO:0000460)3.22245722
96DNA methylation (GO:0006306)3.22042848
97DNA alkylation (GO:0006305)3.22042848
98CDP-diacylglycerol biosynthetic process (GO:0016024)3.20069525
99protein localization to chromosome (GO:0034502)3.19843738
100cilium or flagellum-dependent cell motility (GO:0001539)3.18823693
101multicellular organism reproduction (GO:0032504)3.18809360
102kynurenine metabolic process (GO:0070189)3.17753402
103microtubule depolymerization (GO:0007019)3.17571461
104GDP-mannose metabolic process (GO:0019673)3.17210037
105cellular biogenic amine catabolic process (GO:0042402)3.14472791
106amine catabolic process (GO:0009310)3.14472791
107regulation of double-strand break repair via homologous recombination (GO:0010569)3.14046839
108histone H3-K9 modification (GO:0061647)3.13731780
109formation of translation preinitiation complex (GO:0001731)3.12135183
110meiotic chromosome segregation (GO:0045132)3.11735325
111pseudouridine synthesis (GO:0001522)3.11006984
112serine family amino acid catabolic process (GO:0009071)3.10903336
113chromatin remodeling at centromere (GO:0031055)3.10696181
114spliceosomal snRNP assembly (GO:0000387)3.10078035
115peptidyl-lysine methylation (GO:0018022)3.09626186
116piRNA metabolic process (GO:0034587)3.09247647
117glycine metabolic process (GO:0006544)3.09176480
118positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.07856192
119negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.07688794
120ribonucleoprotein complex biogenesis (GO:0022613)3.06603063
121positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.05836100
122regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.05252830
123histone-serine phosphorylation (GO:0035404)3.05073077
124DNA replication-independent nucleosome assembly (GO:0006336)3.04271204
125DNA replication-independent nucleosome organization (GO:0034724)3.04271204
126DNA deamination (GO:0045006)3.03194837
127flavonoid metabolic process (GO:0009812)3.02723462
128phosphatidylethanolamine biosynthetic process (GO:0006646)3.01103446
129modified amino acid transport (GO:0072337)3.00629092
130L-methionine salvage (GO:0071267)3.00160116
131L-methionine biosynthetic process (GO:0071265)3.00160116
132amino acid salvage (GO:0043102)3.00160116
133rRNA processing (GO:0006364)3.00032017
134pantothenate metabolic process (GO:0015939)3.00006979
135monoubiquitinated protein deubiquitination (GO:0035520)2.99879596
136oocyte maturation (GO:0001556)2.99515650
137regulation of cilium movement (GO:0003352)2.97658642
138positive regulation of viral transcription (GO:0050434)2.97413918
139protein insertion into membrane (GO:0051205)2.97095655
140autophagic vacuole assembly (GO:0000045)2.96377920
141synaptonemal complex organization (GO:0070193)2.95324894
142rRNA metabolic process (GO:0016072)2.94454273
143protein K63-linked deubiquitination (GO:0070536)2.94273467
144mitotic spindle checkpoint (GO:0071174)2.91832077
145proteasome assembly (GO:0043248)2.88858477
146positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.87257099
147positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.87257099
148positive regulation of mitotic sister chromatid separation (GO:1901970)2.87257099
149cellular response to exogenous dsRNA (GO:0071360)2.86919441
150phosphatidylethanolamine metabolic process (GO:0046337)2.85819025
151positive regulation of digestive system process (GO:0060456)2.85299146
152gene silencing by RNA (GO:0031047)2.85055854
153positive regulation of ligase activity (GO:0051351)2.84462038
154DNA methylation or demethylation (GO:0044728)2.81504628
155negative regulation of interleukin-8 production (GO:0032717)2.81399057
156striated muscle atrophy (GO:0014891)2.81347766
157histone H3-K4 methylation (GO:0051568)2.79920248
158cellular response to ATP (GO:0071318)2.79882617
159nicotinamide nucleotide biosynthetic process (GO:0019359)2.79568431
160pyridine nucleotide biosynthetic process (GO:0019363)2.79568431
161behavioral response to nicotine (GO:0035095)2.79544947
162histone lysine methylation (GO:0034968)2.77973374
163gonadal mesoderm development (GO:0007506)2.76332305
164positive regulation of histone deacetylation (GO:0031065)2.74806770
165regulation of nuclear cell cycle DNA replication (GO:0033262)2.74563642
166regulation of gamma-delta T cell differentiation (GO:0045586)2.74318611
167nodal signaling pathway (GO:0038092)2.74185913
168negative regulation of translation, ncRNA-mediated (GO:0040033)2.72481866
169regulation of translation, ncRNA-mediated (GO:0045974)2.72481866
170negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.72481866
171cellular ketone body metabolic process (GO:0046950)2.71557680
172DNA modification (GO:0006304)2.71452577
173iron-sulfur cluster assembly (GO:0016226)2.70681476
174metallo-sulfur cluster assembly (GO:0031163)2.70681476
175gene silencing (GO:0016458)2.69734194
176regulation of pigment cell differentiation (GO:0050932)2.69495864
177rhodopsin mediated signaling pathway (GO:0016056)2.69184601
178sulfation (GO:0051923)2.67086045
179cellular response to ethanol (GO:0071361)2.66845766
180negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.66536142
181acrosome reaction (GO:0007340)2.65559972
182regulation of defense response to virus by host (GO:0050691)2.64504783
183regulation of rhodopsin mediated signaling pathway (GO:0022400)2.61876583
184positive regulation of defense response to virus by host (GO:0002230)2.59363169
185sex determination (GO:0007530)2.58782873
186purine deoxyribonucleotide catabolic process (GO:0009155)2.58138046
187positive regulation of protein kinase C signaling (GO:0090037)2.56861917
188tRNA modification (GO:0006400)2.55769285
189negative regulation of calcium ion transport into cytosol (GO:0010523)2.54954828
190photoreceptor cell maintenance (GO:0045494)2.54705502
191sulfate transmembrane transport (GO:1902358)2.53006183
192axoneme assembly (GO:0035082)2.52125979
193oxidative demethylation (GO:0070989)2.51982251
194imidazole-containing compound metabolic process (GO:0052803)2.51563076
195regulation of hydrogen peroxide metabolic process (GO:0010310)2.50933267
196aromatic amino acid family metabolic process (GO:0009072)2.48422567
197aromatic amino acid family catabolic process (GO:0009074)2.48125747
198sensory perception of smell (GO:0007608)13.9847651

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.97913999
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.62631682
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.35191982
4E2F7_22180533_ChIP-Seq_HELA_Human4.00925762
5CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human3.20354737
6CREB1_15753290_ChIP-ChIP_HEK293T_Human3.17037149
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.16152618
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.16114499
9ZNF263_19887448_ChIP-Seq_K562_Human3.13123807
10AR_21909140_ChIP-Seq_LNCAP_Human3.09042883
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.00988929
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.98326943
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.91627762
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.89211920
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.82400685
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.80639669
17ZNF274_21170338_ChIP-Seq_K562_Hela2.70115986
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.69570420
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.58575991
20SCL_19346495_ChIP-Seq_HPC-7_Human2.56494544
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.42252018
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.37718458
23VDR_21846776_ChIP-Seq_THP-1_Human2.37005196
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.33241009
25DROSHA_22980978_ChIP-Seq_HELA_Human2.32834915
26EST1_17652178_ChIP-ChIP_JURKAT_Human2.31566680
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.26037420
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.25178534
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.24710717
30BCOR_27268052_Chip-Seq_Bcells_Human2.21600828
31P68_20966046_ChIP-Seq_HELA_Human2.19784452
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.18478314
33NANOG_18555785_ChIP-Seq_MESCs_Mouse2.16612385
34MYC_19030024_ChIP-ChIP_MESCs_Mouse2.16277996
35MYC_18358816_ChIP-ChIP_MESCs_Mouse2.10778310
36KAP1_22055183_ChIP-Seq_ESCs_Mouse2.08368952
37VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.06570682
38ERA_21632823_ChIP-Seq_H3396_Human2.02723049
39VDR_23849224_ChIP-Seq_CD4+_Human2.02257461
40* PHF8_20622854_ChIP-Seq_HELA_Human1.95406545
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88007956
42BCL6_27268052_Chip-Seq_Bcells_Human1.86390900
43MYC_22102868_ChIP-Seq_BL_Human1.84956025
44NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.84401116
45VDR_24763502_ChIP-Seq_THP-1_Human1.83989706
46* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.82770234
47KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.82659412
48ELF1_20517297_ChIP-Seq_JURKAT_Human1.82493944
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.82365841
50STAT1_20625510_ChIP-Seq_HELA_Human1.76711006
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.76425999
52RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73967143
53* OCT4_20526341_ChIP-Seq_ESCs_Human1.72054847
54SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.71386097
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.71027527
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.69982381
57* RAC3_21632823_ChIP-Seq_H3396_Human1.69975809
58* SMC4_20622854_ChIP-Seq_HELA_Human1.69529495
59XRN2_22483619_ChIP-Seq_HELA_Human1.69381742
60NELFA_20434984_ChIP-Seq_ESCs_Mouse1.68458531
61* P300_27268052_Chip-Seq_Bcells_Human1.66286256
62SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.65638424
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.64832539
64KDM5A_27292631_Chip-Seq_BREAST_Human1.64728854
65YY1_22570637_ChIP-Seq_MALME-3M_Human1.64643521
66VDR_22108803_ChIP-Seq_LS180_Human1.62647296
67* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.61125377
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.60717318
69GABP_19822575_ChIP-Seq_HepG2_Human1.58769640
70HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.55665794
71EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53476175
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.53370265
73LXR_22292898_ChIP-Seq_THP-1_Human1.53195000
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52155922
75E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49972764
76* MAF_26560356_Chip-Seq_TH2_Human1.48287417
77BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.47723454
78PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45881702
79CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.44567011
80E2F1_21310950_ChIP-Seq_MCF-7_Human1.44242299
81* TP63_22573176_ChIP-Seq_HFKS_Human1.42027446
82TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.39477688
83ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38987389
84* OCT4_19829295_ChIP-Seq_ESCs_Human1.37458579
85LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36627028
86FOXP3_21729870_ChIP-Seq_TREG_Human1.35716132
87* UTX_26944678_Chip-Seq_JUKART_Human1.35183480
88POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.34814669
89CTCF_20526341_ChIP-Seq_ESCs_Human1.34258652
90KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32544868
91TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31821612
92HOXB7_26014856_ChIP-Seq_BT474_Human1.30924414
93EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30354364
94NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.28238095
95CTCF_27219007_Chip-Seq_Bcells_Human1.28030895
96RUNX1_27514584_Chip-Seq_MCF-7_Human1.26946785
97* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25864614
98AR_21572438_ChIP-Seq_LNCaP_Human1.25737796
99GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25319171
100P53_21459846_ChIP-Seq_SAOS-2_Human1.22993106
101GATA3_21878914_ChIP-Seq_MCF-7_Human1.22802641
102WDR5_24793694_ChIP-Seq_LNCAP_Human1.22734429
103RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.21129103
104EGR1_23403033_ChIP-Seq_LIVER_Mouse1.20396007
105CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19473092
106MYC_19829295_ChIP-Seq_ESCs_Human1.18627277
107NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.18276957
108IGF1R_20145208_ChIP-Seq_DFB_Human1.17375121
109RUNX_20019798_ChIP-Seq_JUKART_Human1.17320458
110NANOG_21062744_ChIP-ChIP_HESCs_Human1.16240569
111KAP1_27257070_Chip-Seq_ESCs_Mouse1.16008218
112P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.15821588
113GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15597319
114NANOG_20526341_ChIP-Seq_ESCs_Human1.15513914
115TDRD3_21172665_ChIP-Seq_MCF-7_Human1.14563827
116SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13921870
117MYB_26560356_Chip-Seq_TH2_Human1.13840188
118* BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.13435870
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11798517
120CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11608834
121* GATA1_19941827_ChIP-Seq_MEL_Mouse1.11569765
122PKCTHETA_26484144_Chip-Seq_BREAST_Human1.10683320
123DCP1A_22483619_ChIP-Seq_HELA_Human1.10519592
124SPI1_23127762_ChIP-Seq_K562_Human1.10290419
125GATA1_19941826_ChIP-Seq_K562_Human1.10017812
126HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.09996197
127RARB_24833708_ChIP-Seq_LIVER_Mouse1.08367625
128POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.08099456
129CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07998067
130TP63_19390658_ChIP-ChIP_HaCaT_Human1.07942871
131IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07244528
132TCF7_22412390_ChIP-Seq_EML_Mouse1.07226642
133TAF2_19829295_ChIP-Seq_ESCs_Human1.06353163
134MAF_26560356_Chip-Seq_TH1_Human1.06272117
135SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06085035
136NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05517450
137ER_23166858_ChIP-Seq_MCF-7_Human1.05398557
138ELK1_22589737_ChIP-Seq_MCF10A_Human1.04842169
139IRF8_21731497_ChIP-ChIP_J774_Mouse1.04202934
140TCF3_18692474_ChIP-Seq_MEFs_Mouse1.03585636
141GATA3_26560356_Chip-Seq_TH2_Human1.03174362
142ESR1_21235772_ChIP-Seq_MCF-7_Human1.02024531
143JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01898699
144DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01360540
145* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01257812
146TTF2_22483619_ChIP-Seq_HELA_Human1.01051394
147FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00953537
148* ATF3_27146783_Chip-Seq_COLON_Human1.00801662
149MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00449012
150MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00101251
151LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99996162
152MYB_26560356_Chip-Seq_TH1_Human0.99451342
153PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99391736
154EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99163920
155FOXH1_21741376_ChIP-Seq_ESCs_Human0.99062967
156CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98787712
157TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98168838
158KLF4_19829295_ChIP-Seq_ESCs_Human0.97899287
159POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97085669
160TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97085669
161PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96530134
162SOX2_18692474_ChIP-Seq_MESCs_Mouse0.96504540
163CREB1_26743006_Chip-Seq_LNCaP_Human0.96486207
164AHR_22903824_ChIP-Seq_MCF-7_Human0.96463072
165STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95892748
166OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94746195
167SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94181942
168ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94004424
169E2F1_20622854_ChIP-Seq_HELA_Human0.93934207
170SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93107244
171CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92127345
172TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.91937561
173TCF3_18692474_ChIP-Seq_MESCs_Mouse0.90320391
174ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89544335
175STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89446540
176KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88493963
177TET1_21451524_ChIP-Seq_MESCs_Mouse0.88103621
178NANOG_18692474_ChIP-Seq_MEFs_Mouse0.86749047
179GATA1_26923725_Chip-Seq_HPCs_Mouse0.86542426
180SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.86148259
181EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.85968249
182YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85248767
183NANOG_18692474_ChIP-Seq_MESCs_Mouse0.84725268
184SALL1_21062744_ChIP-ChIP_HESCs_Human0.83759746
185TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82748431
186NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.82438205
187KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.80912407
188NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.80763768
189CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80750804
190ELK1_19687146_ChIP-ChIP_HELA_Human0.78493262
191GATA3_21867929_ChIP-Seq_CD8_Mouse0.78365073
192SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.77326586
193FOXP1_21924763_ChIP-Seq_HESCs_Human0.77313505
194HOXB4_20404135_ChIP-ChIP_EML_Mouse0.77292112
195NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.77145273
196STAT6_21828071_ChIP-Seq_BEAS2B_Human0.77081598

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction9.58636290
2MP0003693_abnormal_embryo_hatching5.68296260
3MP0005499_abnormal_olfactory_system4.58157061
4MP0005394_taste/olfaction_phenotype4.58157061
5MP0003718_maternal_effect3.74859166
6MP0008789_abnormal_olfactory_epithelium3.66049600
7MP0003136_yellow_coat_color3.64139476
8MP0003111_abnormal_nucleus_morphology3.53522033
9MP0003646_muscle_fatigue3.36525093
10MP0008875_abnormal_xenobiotic_pharmacok3.33913835
11MP0003045_fibrosis3.23517740
12MP0004957_abnormal_blastocyst_morpholog2.95712143
13MP0002254_reproductive_system_inflammat2.91585238
14MP0005171_absent_coat_pigmentation2.84590456
15MP0002138_abnormal_hepatobiliary_system2.72721610
16MP0001986_abnormal_taste_sensitivity2.64891717
17MP0005670_abnormal_white_adipose2.59554435
18MP0003195_calcinosis2.57860319
19MP0003077_abnormal_cell_cycle2.39466586
20MP0005410_abnormal_fertilization2.29015159
21MP0003123_paternal_imprinting2.21032469
22MP0010094_abnormal_chromosome_stability2.16645104
23MP0008260_abnormal_autophagy2.13606181
24MP0004043_abnormal_pH_regulation1.94603849
25MP0008057_abnormal_DNA_replication1.88919942
26MP0005083_abnormal_biliary_tract1.85700233
27MP0004381_abnormal_hair_follicle1.83781686
28MP0005377_hearing/vestibular/ear_phenot1.81195268
29MP0003878_abnormal_ear_physiology1.81195268
30MP0003172_abnormal_lysosome_physiology1.80794100
31MP0001501_abnormal_sleep_pattern1.77507066
32MP0003183_abnormal_peptide_metabolism1.76163232
33MP0001730_embryonic_growth_arrest1.70653823
34MP0005174_abnormal_tail_pigmentation1.62639066
35MP0002653_abnormal_ependyma_morphology1.61894195
36MP0005451_abnormal_body_composition1.60539220
37MP0001545_abnormal_hematopoietic_system1.60371888
38MP0005397_hematopoietic_system_phenotyp1.60371888
39MP0003763_abnormal_thymus_physiology1.57694899
40MP0003786_premature_aging1.57501661
41MP0003806_abnormal_nucleotide_metabolis1.57003850
42MP0005551_abnormal_eye_electrophysiolog1.56498764
43MP0009333_abnormal_splenocyte_physiolog1.51071806
44MP0008058_abnormal_DNA_repair1.50858397
45MP0000350_abnormal_cell_proliferation1.49528279
46MP0001873_stomach_inflammation1.49146082
47MP0001800_abnormal_humoral_immune1.45662897
48MP0005395_other_phenotype1.44210200
49MP0008995_early_reproductive_senescence1.43599508
50MP0000015_abnormal_ear_pigmentation1.42818084
51MP0009840_abnormal_foam_cell1.42675708
52MP0002168_other_aberrant_phenotype1.41862162
53MP0005645_abnormal_hypothalamus_physiol1.40580076
54MP0001542_abnormal_bone_strength1.38728877
55MP0010234_abnormal_vibrissa_follicle1.35675384
56MP0008961_abnormal_basal_metabolism1.32919736
57MP0001485_abnormal_pinna_reflex1.30552445
58MP0001968_abnormal_touch/_nociception1.29655990
59MP0001661_extended_life_span1.29466551
60MP0005671_abnormal_response_to1.29308384
61MP0008932_abnormal_embryonic_tissue1.28050569
62MP0000383_abnormal_hair_follicle1.25670198
63MP0000685_abnormal_immune_system1.25182632
64MP0001672_abnormal_embryogenesis/_devel1.23785562
65MP0005380_embryogenesis_phenotype1.23785562
66MP0003938_abnormal_ear_development1.19248154
67MP0004147_increased_porphyrin_level1.18152738
68MP0008007_abnormal_cellular_replicative1.17371101
69MP0005360_urolithiasis1.16581978
70MP0002723_abnormal_immune_serum1.14219496
71MP0009278_abnormal_bone_marrow1.13919870
72MP0001790_abnormal_immune_system1.13053863
73MP0005387_immune_system_phenotype1.13053863
74MP0003221_abnormal_cardiomyocyte_apopto1.12237914
75MP0002452_abnormal_antigen_presenting1.10828464
76MP0003315_abnormal_perineum_morphology1.10630398
77MP0002396_abnormal_hematopoietic_system1.09309855
78MP0004019_abnormal_vitamin_homeostasis1.08330643
79MP0008877_abnormal_DNA_methylation1.07795223
80MP0010030_abnormal_orbit_morphology1.06670609
81MP0005266_abnormal_metabolism1.06326287
82MP0003252_abnormal_bile_duct1.06253697
83MP0002210_abnormal_sex_determination1.05524404
84MP0006292_abnormal_olfactory_placode1.05385076
85MP0002332_abnormal_exercise_endurance1.04563333
86MP0003984_embryonic_growth_retardation1.03303049
87MP0000470_abnormal_stomach_morphology1.02392071
88MP0005365_abnormal_bile_salt1.00812437
89MP0002233_abnormal_nose_morphology1.00763032
90MP0002693_abnormal_pancreas_physiology1.00583476
91MP0002088_abnormal_embryonic_growth/wei1.00214186
92MP0002420_abnormal_adaptive_immunity1.00145043
93MP0001145_abnormal_male_reproductive1.00092948
94MP0002277_abnormal_respiratory_mucosa0.99281700
95MP0001819_abnormal_immune_cell0.99204100
96MP0002398_abnormal_bone_marrow0.99078265
97MP0000716_abnormal_immune_system0.98814071
98MP0003186_abnormal_redox_activity0.98438050
99MP0010307_abnormal_tumor_latency0.97863431
100MP0000427_abnormal_hair_cycle0.97853114
101MP0001756_abnormal_urination0.97767480
102MP0005025_abnormal_response_to0.97291647
103MP0002080_prenatal_lethality0.97032672
104MP0002837_dystrophic_cardiac_calcinosis0.95908101
105MP0000689_abnormal_spleen_morphology0.95745000
106MP0001502_abnormal_circadian_rhythm0.94598525
107MP0002148_abnormal_hypersensitivity_rea0.94436410
108MP0002722_abnormal_immune_system0.93485995
109MP0002132_abnormal_respiratory_system0.93476882
110MP0004947_skin_inflammation0.92543129
111MP0001835_abnormal_antigen_presentation0.91308962
112MP0001929_abnormal_gametogenesis0.90688008
113MP0001697_abnormal_embryo_size0.90263298
114MP0008872_abnormal_physiological_respon0.90117360
115MP0000653_abnormal_sex_gland0.89701559
116MP0002085_abnormal_embryonic_tissue0.89373005
117MP0004808_abnormal_hematopoietic_stem0.88804232
118MP0002876_abnormal_thyroid_physiology0.88622677
119MP0004510_myositis0.88490209
120MP0000703_abnormal_thymus_morphology0.87249884
121MP0000516_abnormal_urinary_system0.86589746
122MP0005367_renal/urinary_system_phenotyp0.86589746
123MP0002405_respiratory_system_inflammati0.83935877
124MP0005058_abnormal_lysosome_morphology0.81345530
125MP0002160_abnormal_reproductive_system0.81034246
126MP0005448_abnormal_energy_balance0.79655674
127MP0003950_abnormal_plasma_membrane0.79579531
128MP0002429_abnormal_blood_cell0.79486257
129MP0002933_joint_inflammation0.79387871
130MP0003567_abnormal_fetal_cardiomyocyte0.79142318
131MP0000613_abnormal_salivary_gland0.78017910
132MP0001765_abnormal_ion_homeostasis0.77456391
133MP0004133_heterotaxia0.75659668
134MP0002095_abnormal_skin_pigmentation0.74206661
135MP0005085_abnormal_gallbladder_physiolo0.73944496
136MP0009764_decreased_sensitivity_to0.72052337
137MP0004130_abnormal_muscle_cell0.71553400
138MP0002075_abnormal_coat/hair_pigmentati0.70958298
139MP0001666_abnormal_nutrient_absorption0.70793949
140MP0000465_gastrointestinal_hemorrhage0.70760350
141MP0002092_abnormal_eye_morphology0.70465926
142MP0003699_abnormal_female_reproductive0.69607390
143MP0003879_abnormal_hair_cell0.68794754
144MP0003937_abnormal_limbs/digits/tail_de0.68587785
145MP0000627_abnormal_mammary_gland0.68044130
146MP0002086_abnormal_extraembryonic_tissu0.67570545
147MP0003303_peritoneal_inflammation0.64919615
148MP0009703_decreased_birth_body0.64685323
149MP0005621_abnormal_cell_physiology0.63380061
150MP0002084_abnormal_developmental_patter0.63099565
151MP0003656_abnormal_erythrocyte_physiolo0.62370041
152MP0000313_abnormal_cell_death0.62338719
153MP0005187_abnormal_penis_morphology0.61927009
154MP0001346_abnormal_lacrimal_gland0.61064400
155MP0005076_abnormal_cell_differentiation0.59627136
156MP0002161_abnormal_fertility/fecundity0.59348266
157MP0003566_abnormal_cell_adhesion0.58590555
158MP0005310_abnormal_salivary_gland0.56095403
159MP0009672_abnormal_birth_weight0.56076848
160MP0005389_reproductive_system_phenotype0.55954883
161MP0003936_abnormal_reproductive_system0.55726901
162MP0001764_abnormal_homeostasis0.54515132
163MP0004185_abnormal_adipocyte_glucose0.53278674
164MP0005384_cellular_phenotype0.52068121
165MP0000750_abnormal_muscle_regeneration0.50311223
166MP0003329_amyloid_beta_deposits0.50174179
167MP0010678_abnormal_skin_adnexa0.50161327
168MP0000609_abnormal_liver_physiology0.49142032
169MP0003448_altered_tumor_morphology0.48127763
170MP0003698_abnormal_male_reproductive0.47583468
171MP0002019_abnormal_tumor_incidence0.47406913
172MP0001119_abnormal_female_reproductive0.46290503

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinemia (HP:0002154)6.80421797
2Birth length less than 3rd percentile (HP:0003561)5.57767796
3Hyperglycinuria (HP:0003108)5.53729306
4Atrioventricular block (HP:0001678)5.32294802
5Breast hypoplasia (HP:0003187)5.15071570
6Genetic anticipation (HP:0003743)5.05704952
7Clumsiness (HP:0002312)4.59945208
8Abnormality of glycine metabolism (HP:0010895)4.58829669
9Abnormality of serine family amino acid metabolism (HP:0010894)4.58829669
10Impulsivity (HP:0100710)4.56350196
11Carpal bone hypoplasia (HP:0001498)4.55755614
12Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.53321613
13Congenital stationary night blindness (HP:0007642)4.47608071
14Increased neuronal autofluorescent lipopigment (HP:0002074)4.47048725
15Attenuation of retinal blood vessels (HP:0007843)4.43000137
16Multiple enchondromatosis (HP:0005701)4.12160239
17Ventricular fibrillation (HP:0001663)4.08275268
18Cerebral hypomyelination (HP:0006808)4.01159678
19Amelogenesis imperfecta (HP:0000705)3.85010673
20Aplasia/Hypoplasia of the patella (HP:0006498)3.77985145
21Abnormality of the labia minora (HP:0012880)3.65129644
22Rough bone trabeculation (HP:0100670)3.64884042
23Increased cerebral lipofuscin (HP:0011813)3.51748062
24Bony spicule pigmentary retinopathy (HP:0007737)3.51674967
25Patellar aplasia (HP:0006443)3.49774812
26Poikiloderma (HP:0001029)3.49313143
27Ankle contracture (HP:0006466)3.39985572
28Heart block (HP:0012722)3.35255904
29Absent rod-and cone-mediated responses on ERG (HP:0007688)3.34927288
30Ureteral duplication (HP:0000073)3.30685696
31Pancreatic cysts (HP:0001737)3.29001253
32Hypoplasia of the pons (HP:0012110)3.25814793
33Bundle branch block (HP:0011710)3.18816306
34Entropion (HP:0000621)3.16885884
35Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.13761024
36Abnormal atrioventricular conduction (HP:0005150)3.07514869
37Abnormal rod and cone electroretinograms (HP:0008323)3.05743090
38Abnormality of serum amino acid levels (HP:0003112)3.04910710
39Abnormal drinking behavior (HP:0030082)3.04230529
40Polydipsia (HP:0001959)3.04230529
41Panhypogammaglobulinemia (HP:0003139)3.02632969
42Severe visual impairment (HP:0001141)2.97838847
43Premature rupture of membranes (HP:0001788)2.96716554
44Abnormality of the umbilical cord (HP:0010881)2.95771938
45Abnormality of the pons (HP:0007361)2.93528827
46Progressive cerebellar ataxia (HP:0002073)2.93454405
47Facial diplegia (HP:0001349)2.93125084
48Gout (HP:0001997)2.89166043
49Secondary amenorrhea (HP:0000869)2.86101201
50Abnormal spermatogenesis (HP:0008669)2.84749900
51Autoimmune thrombocytopenia (HP:0001973)2.81128787
52Pendular nystagmus (HP:0012043)2.80929760
53Abnormality of B cell number (HP:0010975)2.77237297
54Horseshoe kidney (HP:0000085)2.76206014
55Abnormal trabecular bone morphology (HP:0100671)2.75072663
56Abnormalities of placenta or umbilical cord (HP:0001194)2.73825607
57Osteolytic defects of the phalanges of the hand (HP:0009771)2.71033305
58Osteolytic defects of the hand bones (HP:0009699)2.71033305
59Abnormality of the fingertips (HP:0001211)2.70595365
60Azoospermia (HP:0000027)2.69267227
61Decreased circulating renin level (HP:0003351)2.69108096
62Breast aplasia (HP:0100783)2.65190000
63Microretrognathia (HP:0000308)2.64064943
64Cystic liver disease (HP:0006706)2.62864040
65CNS hypomyelination (HP:0003429)2.61684545
66Gaze-evoked nystagmus (HP:0000640)2.61306285
67Progressive muscle weakness (HP:0003323)2.53975995
68Male infertility (HP:0003251)2.52853361
69Syncope (HP:0001279)2.52634120
70Protruding tongue (HP:0010808)2.51643853
71Oligodactyly (hands) (HP:0001180)2.50039625
72Pustule (HP:0200039)2.49957024
73Macular degeneration (HP:0000608)2.49658661
74Death in infancy (HP:0001522)2.47441519
75Aplasia/Hypoplasia of the breasts (HP:0010311)2.46644023
76Agammaglobulinemia (HP:0004432)2.45926725
77Ulnar bowing (HP:0003031)2.45794937
78Aplasia/hypoplasia of the uterus (HP:0008684)2.43304888
79Areflexia of lower limbs (HP:0002522)2.39760227
80Acute lymphatic leukemia (HP:0006721)2.39708209
81Congenital, generalized hypertrichosis (HP:0004540)2.39649904
82Stillbirth (HP:0003826)2.38798844
83Restlessness (HP:0000711)2.38538102
84Abolished electroretinogram (ERG) (HP:0000550)2.37124021
85Polycythemia (HP:0001901)2.36055981
86Facial hemangioma (HP:0000329)2.35857476
87Abnormality of the distal phalanges of the toes (HP:0010182)2.34684194
88Premature ovarian failure (HP:0008209)2.34353325
89Decreased central vision (HP:0007663)2.34158954
90Enlarged penis (HP:0000040)2.33220933
91Stomach cancer (HP:0012126)2.29742468
92Absent radius (HP:0003974)2.29416026
93Tetraplegia (HP:0002445)2.28976217
94Muscle fiber splitting (HP:0003555)2.28433747
95Decreased electroretinogram (ERG) amplitude (HP:0000654)2.23752512
96Dysmetric saccades (HP:0000641)2.23565416
97Colitis (HP:0002583)2.23565058
98Mutism (HP:0002300)2.21956388
99Dysautonomia (HP:0002459)2.21759027
100Abnormality of the renal collecting system (HP:0004742)2.21508897
101Duplicated collecting system (HP:0000081)2.21174663
102Short nail (HP:0001799)2.19362387
103Aplasia/Hypoplasia involving the musculature (HP:0001460)2.19220140
104Aplasia involving forearm bones (HP:0009822)2.16456823
105Absent forearm bone (HP:0003953)2.16456823
106Small epiphyses (HP:0010585)2.15731465
107Delusions (HP:0000746)2.15478031
108Constricted visual fields (HP:0001133)2.15457544
109Vaginal fistula (HP:0004320)2.14186891
110Trismus (HP:0000211)2.14033879
111Stenosis of the external auditory canal (HP:0000402)2.13735714
112Hyperventilation (HP:0002883)2.11779348
113Tubular atrophy (HP:0000092)2.11510132
114B lymphocytopenia (HP:0010976)2.11272751
115Chronic hepatic failure (HP:0100626)2.11216381
116Intestinal fistula (HP:0100819)2.11099082
117Hypoplastic iliac wings (HP:0002866)2.10829682
118Hypoplasia of the thymus (HP:0000778)2.09652111
119True hermaphroditism (HP:0010459)2.09302787
120Glossoptosis (HP:0000162)2.09234970
121Personality changes (HP:0000751)2.08735074
122Retinitis pigmentosa (HP:0000510)2.06801215
123Polyuria (HP:0000103)2.06731801
124Pancreatic fibrosis (HP:0100732)2.06656239
125Abnormal delayed hypersensitivity skin test (HP:0002963)2.06433328
126Abnormality of DNA repair (HP:0003254)2.05135232
127Sparse eyelashes (HP:0000653)2.04765187
128Abnormality of midbrain morphology (HP:0002418)2.04660470
129Molar tooth sign on MRI (HP:0002419)2.04660470
130Oligodactyly (HP:0012165)2.03774309
131Abnormal albumin level (HP:0012116)2.03569911
132Hypoalbuminemia (HP:0003073)2.03569911
133Cerebellar dysplasia (HP:0007033)2.03409072
134Synostosis involving the elbow (HP:0003938)2.00616940
135Humeroradial synostosis (HP:0003041)2.00616940
136Abnormality of the anterior horn cell (HP:0006802)2.00552366
137Degeneration of anterior horn cells (HP:0002398)2.00552366
138Glucose intolerance (HP:0000833)1.98308513
139Abnormality of the labia (HP:0000058)1.97923312
140Lip pit (HP:0100267)1.97071423
141Wrist flexion contracture (HP:0001239)1.96245302
142Abnormality of the clitoris (HP:0000056)1.96236790
143Hypoplasia of the uterus (HP:0000013)1.96053635
144Autoimmune hemolytic anemia (HP:0001890)1.95271515
145Tetany (HP:0001281)1.95050251
146Severe combined immunodeficiency (HP:0004430)1.94446928
147Nephronophthisis (HP:0000090)1.94020056
148Abnormal cartilage morphology (HP:0002763)1.91937417
149Hyperglycemia (HP:0003074)1.91216399
150Postural instability (HP:0002172)1.90780615
151Choanal stenosis (HP:0000452)1.89695551
152Clitoromegaly (HP:0000057)1.89095007
153Abnormality of the renal cortex (HP:0011035)1.88897627
154Recurrent fungal infections (HP:0002841)1.88602057
155Abnormal delivery (HP:0001787)1.88307802
156Meckel diverticulum (HP:0002245)1.87224071
157Abnormality of cochlea (HP:0000375)1.85687314
158Atresia of the external auditory canal (HP:0000413)1.83483840
159Abnormality of the hepatic vasculature (HP:0006707)1.82351622
160Abnormal EKG (HP:0003115)1.82247574
161Carpal synostosis (HP:0009702)1.81488824
162Facial cleft (HP:0002006)1.81096742
163Abnormality of the renal medulla (HP:0100957)1.80432807
164Type I transferrin isoform profile (HP:0003642)1.79410352
165Dysphonia (HP:0001618)1.78889541
166Photophobia (HP:0000613)1.75843343
167Abnormality of homocysteine metabolism (HP:0010919)1.75360860
168Homocystinuria (HP:0002156)1.75360860
169Neoplasm of the pancreas (HP:0002894)1.74781911
170Ectropion (HP:0000656)1.74591554
171Urethral obstruction (HP:0000796)1.73225194
172Chromosomal breakage induced by crosslinking agents (HP:0003221)1.73152538
173Prominent nose (HP:0000448)1.72736229
174Bronchomalacia (HP:0002780)1.72352752
175Brittle hair (HP:0002299)1.72117419
176Patent foramen ovale (HP:0001655)1.71680000
177Hypoplastic ischia (HP:0003175)1.70482148
178Progressive inability to walk (HP:0002505)1.69896135
179Hyperkalemia (HP:0002153)1.68257518
180Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.67256942
181Neonatal respiratory distress (HP:0002643)1.66894560
182Ileus (HP:0002595)1.65727049
183Prostate neoplasm (HP:0100787)1.64797690
184Dialeptic seizures (HP:0011146)1.64696552
185Difficulty walking (HP:0002355)1.63852831
186Elevated erythrocyte sedimentation rate (HP:0003565)1.63612417
187Depressed nasal tip (HP:0000437)1.63047815
188Cone-rod dystrophy (HP:0000548)1.61995251
189Thyroiditis (HP:0100646)1.60091020
190Abnormal urine output (HP:0012590)1.59914956

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.29196573
2WEE14.69639907
3NEK23.50661133
4CDK123.33977206
5BRSK23.31014968
6INSRR3.13574999
7TTK2.97124704
8SRPK12.81328294
9EIF2AK12.74048437
10TSSK62.52534924
11TAOK32.18284185
12PLK12.17572073
13BRSK12.15788458
14PLK32.14907742
15PLK42.08744960
16DYRK32.01340208
17EIF2AK31.96369070
18TNK21.95281021
19AKT31.92245167
20NEK11.91839305
21PDK31.89338452
22PDK41.89338452
23MAP4K11.81841356
24EEF2K1.81335910
25STK38L1.81303015
26ALK1.80070590
27TRIB31.77100336
28MKNK21.76690844
29SIK21.73942498
30IRAK31.71074295
31EPHA21.68012756
32ERN11.64089933
33LATS21.63286188
34FRK1.62528209
35STK31.62401765
36LATS11.60549748
37BMPR1B1.56362729
38BLK1.46092347
39ADRBK21.45873248
40PDK21.40397196
41CHEK21.37677225
42GRK11.35808732
43BMX1.35675886
44PRKD21.33496560
45NLK1.31917113
46PIK3CG1.31315512
47ICK1.30817007
48AURKB1.30322311
49CCNB11.29091611
50SIK11.27906662
51ACVR1B1.26542930
52STK161.24559342
53TLK11.23159829
54IKBKB1.21415104
55RPS6KA41.20451125
56KDR1.18719483
57PINK11.14943641
58WNK41.14103945
59IKBKE1.12632855
60AURKA1.11307008
61STK241.11291232
62PRKAA21.10251188
63MAP2K61.10209163
64CDC42BPA1.07293145
65MUSK1.06119036
66BTK1.05380257
67MKNK11.04934841
68MAP3K71.04739344
69MAPK111.04658532
70TXK1.02703195
71CSNK1G31.02509663
72CSNK1A1L1.01496545
73ITK1.01328918
74CDC71.01262989
75ZAP701.00640496
76NUAK11.00519383
77EIF2AK20.99786194
78PRKCI0.98957654
79CSNK1G10.97181049
80NME20.95882112
81TEC0.94856575
82ARAF0.92776622
83CHUK0.91974798
84DAPK20.90700082
85PNCK0.88547804
86TESK20.86376574
87ADRBK10.85948455
88MTOR0.85862377
89MAP3K80.84768371
90PAK30.82306158
91DYRK20.81940573
92KIT0.80044255
93MARK20.79331634
94TYRO30.77492203
95SIK30.77000619
96CSNK1G20.76409183
97MAP3K90.76356802
98BRAF0.76197243
99CDK70.75331860
100MARK30.74955765
101CAMK1D0.74680914
102CHEK10.72588559
103CAMK2G0.70913684
104PAK10.69893823
105SYK0.69475408
106CAMK2B0.69377306
107NME10.69301030
108CDK40.67497805
109PRKD30.66328546
110TRPM70.64955249
111RIPK10.62969922
112PRKAA10.62148438
113LCK0.61855597
114PRKCG0.61778873
115HIPK20.59697635
116PTK2B0.57975982
117PIM10.57682878
118STK40.57665484
119CAMK2D0.57336358
120TAOK10.57179049
121TBK10.56892036
122MAP3K30.56633525
123PKN20.55255467
124STK380.51984134
125RPS6KA60.51838553
126IRAK10.50660529
127CSNK1E0.49672199
128OXSR10.48482420
129LYN0.48192509
130MAP2K30.47708887
131ERBB30.47478403
132MAPK80.46578329
133PRKD10.45380506
134ZAK0.44348076
135CDK20.42760241
136STK390.42104225
137CDK60.41170377
138BRD40.41055970
139ABL20.40535846
140MAPK10.40438715
141MAP3K60.40372693
142PIM20.40355176
143CSNK2A10.39823359
144MAP2K20.39703540
145MST1R0.39399140
146RPS6KB20.39250389
147FLT30.38920819
148CSF1R0.38838737
149MAPK130.38607300
150PAK40.38368004
151FES0.37136421
152MAPK150.36723852
153HCK0.36470716
154MAPK30.36089169
155VRK10.35559409
156CDK10.34397413
157TGFBR10.34120950
158PDK10.33947218
159CDK30.33606221
160MAPKAPK30.33365386
161MELK0.32646182
162AKT10.32346490
163CSNK2A20.31935776
164PRKCQ0.30882273
165STK100.29515842
166MAP4K20.29340765
167CSNK1A10.29035942
168ATR0.28974530
169RPS6KA10.28637011
170IRAK40.28204966
171GRK60.27687903
172PAK60.27621873
173KSR20.26041211
174PDPK10.25368918
175STK110.25140531

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.85813522
2RNA polymerase_Homo sapiens_hsa030204.68093996
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.94474015
4Olfactory transduction_Homo sapiens_hsa047403.46814354
5Primary immunodeficiency_Homo sapiens_hsa053402.86004158
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.80866361
7RNA transport_Homo sapiens_hsa030132.78999673
8Glutathione metabolism_Homo sapiens_hsa004802.78038736
9Proteasome_Homo sapiens_hsa030502.74807468
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.67001591
11Phototransduction_Homo sapiens_hsa047442.64035771
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.59464473
13ABC transporters_Homo sapiens_hsa020102.50759577
14Lysine degradation_Homo sapiens_hsa003102.36209340
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.19630389
16Pyrimidine metabolism_Homo sapiens_hsa002402.14654317
17Regulation of autophagy_Homo sapiens_hsa041402.14381692
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.11111461
19Caffeine metabolism_Homo sapiens_hsa002322.09843504
20Cell cycle_Homo sapiens_hsa041102.09491383
21Drug metabolism - other enzymes_Homo sapiens_hsa009832.00399226
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.98037162
23Arachidonic acid metabolism_Homo sapiens_hsa005901.97689757
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.96327664
25Taste transduction_Homo sapiens_hsa047421.90545595
26Basal transcription factors_Homo sapiens_hsa030221.87006410
27Pentose phosphate pathway_Homo sapiens_hsa000301.86901030
28Nitrogen metabolism_Homo sapiens_hsa009101.83245472
29Spliceosome_Homo sapiens_hsa030401.77681069
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.76819119
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.76324203
32Purine metabolism_Homo sapiens_hsa002301.74597193
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.69123061
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.65729583
35Glycerophospholipid metabolism_Homo sapiens_hsa005641.57765344
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.55689211
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.53977499
38Oocyte meiosis_Homo sapiens_hsa041141.53764600
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.53622075
40Butanoate metabolism_Homo sapiens_hsa006501.50740883
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.46248395
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.41432930
43Sulfur relay system_Homo sapiens_hsa041221.39684318
44p53 signaling pathway_Homo sapiens_hsa041151.39089693
45Folate biosynthesis_Homo sapiens_hsa007901.37694879
46beta-Alanine metabolism_Homo sapiens_hsa004101.37590866
47Dorso-ventral axis formation_Homo sapiens_hsa043201.34458575
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33412919
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.30177246
50Thyroid hormone synthesis_Homo sapiens_hsa049181.24473868
51DNA replication_Homo sapiens_hsa030301.22951762
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22093041
53Other glycan degradation_Homo sapiens_hsa005111.19591321
54NF-kappa B signaling pathway_Homo sapiens_hsa040641.14779632
55Vitamin digestion and absorption_Homo sapiens_hsa049771.12283308
56Tryptophan metabolism_Homo sapiens_hsa003801.10781653
57Pancreatic secretion_Homo sapiens_hsa049721.04923662
58Morphine addiction_Homo sapiens_hsa050321.04901505
59Homologous recombination_Homo sapiens_hsa034400.98321324
60Calcium signaling pathway_Homo sapiens_hsa040200.96648939
61Histidine metabolism_Homo sapiens_hsa003400.95027959
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94202481
63Nucleotide excision repair_Homo sapiens_hsa034200.94165315
64TNF signaling pathway_Homo sapiens_hsa046680.92559112
65Fatty acid biosynthesis_Homo sapiens_hsa000610.92268616
66Retinol metabolism_Homo sapiens_hsa008300.91905733
67Epstein-Barr virus infection_Homo sapiens_hsa051690.91681536
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91363856
69mRNA surveillance pathway_Homo sapiens_hsa030150.85328403
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85304417
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83594778
72Fanconi anemia pathway_Homo sapiens_hsa034600.82899917
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81690955
74Nicotine addiction_Homo sapiens_hsa050330.80848627
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.80093723
76Notch signaling pathway_Homo sapiens_hsa043300.78903853
77Fat digestion and absorption_Homo sapiens_hsa049750.78363684
78Type II diabetes mellitus_Homo sapiens_hsa049300.77717368
79Mismatch repair_Homo sapiens_hsa034300.74988339
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72808002
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72273338
82Biosynthesis of amino acids_Homo sapiens_hsa012300.72048035
83Ribosome_Homo sapiens_hsa030100.71357032
84T cell receptor signaling pathway_Homo sapiens_hsa046600.71311112
85Selenocompound metabolism_Homo sapiens_hsa004500.69638082
86Insulin resistance_Homo sapiens_hsa049310.69374868
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68925992
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66299939
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65704612
90Hematopoietic cell lineage_Homo sapiens_hsa046400.65675140
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64831588
92Platelet activation_Homo sapiens_hsa046110.64439081
93B cell receptor signaling pathway_Homo sapiens_hsa046620.63704065
94Fructose and mannose metabolism_Homo sapiens_hsa000510.62695967
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61470142
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.61260615
97Base excision repair_Homo sapiens_hsa034100.60652170
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.60187919
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59250867
100Graft-versus-host disease_Homo sapiens_hsa053320.59246273
101Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57898918
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57857007
103VEGF signaling pathway_Homo sapiens_hsa043700.57305041
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.55085402
105Arginine and proline metabolism_Homo sapiens_hsa003300.54858867
106Acute myeloid leukemia_Homo sapiens_hsa052210.54493972
107Serotonergic synapse_Homo sapiens_hsa047260.52909067
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52119324
109Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51982531
110FoxO signaling pathway_Homo sapiens_hsa040680.49296176
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48970304
112Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47280778
113Influenza A_Homo sapiens_hsa051640.47268017
114NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47157765
115Collecting duct acid secretion_Homo sapiens_hsa049660.46113686
116Glutamatergic synapse_Homo sapiens_hsa047240.45956406
117African trypanosomiasis_Homo sapiens_hsa051430.43781532
118MAPK signaling pathway_Homo sapiens_hsa040100.39756689
119Glycerolipid metabolism_Homo sapiens_hsa005610.39658792
120Carbon metabolism_Homo sapiens_hsa012000.39508980
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39501964
122Sphingolipid metabolism_Homo sapiens_hsa006000.39346506
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38872093
124RNA degradation_Homo sapiens_hsa030180.38814127
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38291996
126Metabolic pathways_Homo sapiens_hsa011000.36274711
127Osteoclast differentiation_Homo sapiens_hsa043800.35957427
128Chemical carcinogenesis_Homo sapiens_hsa052040.34014410
129mTOR signaling pathway_Homo sapiens_hsa041500.33428587
130Hepatitis C_Homo sapiens_hsa051600.33406058
131Galactose metabolism_Homo sapiens_hsa000520.33337230
132Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32848198
133Herpes simplex infection_Homo sapiens_hsa051680.32807912
1342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32165554
135Starch and sucrose metabolism_Homo sapiens_hsa005000.31609765
136Estrogen signaling pathway_Homo sapiens_hsa049150.30733036
137Mineral absorption_Homo sapiens_hsa049780.30342697
138Linoleic acid metabolism_Homo sapiens_hsa005910.25602019
139Lysosome_Homo sapiens_hsa041420.24372370
140Intestinal immune network for IgA production_Homo sapiens_hsa046720.23695557
141Salivary secretion_Homo sapiens_hsa049700.21651447
142Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21591442
143Vibrio cholerae infection_Homo sapiens_hsa051100.21120003
144Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.20026792
145Renal cell carcinoma_Homo sapiens_hsa052110.18836577
146Bile secretion_Homo sapiens_hsa049760.16675979
147Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.15046166
148MicroRNAs in cancer_Homo sapiens_hsa052060.14853928
149Circadian rhythm_Homo sapiens_hsa047100.12908152
150Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.12714020
151Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.12647411
152Viral carcinogenesis_Homo sapiens_hsa052030.11593381
153Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.10410978
154Sulfur metabolism_Homo sapiens_hsa009200.10079739
155Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.06651697
156Ovarian steroidogenesis_Homo sapiens_hsa049130.05918760
157Inositol phosphate metabolism_Homo sapiens_hsa005620.03960107
158Prostate cancer_Homo sapiens_hsa052150.03851551
159Tight junction_Homo sapiens_hsa045300.03503822
160AMPK signaling pathway_Homo sapiens_hsa041520.01934464
161One carbon pool by folate_Homo sapiens_hsa006700.01290692
162Ether lipid metabolism_Homo sapiens_hsa00565-0.0234949

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