SLC22A23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SLC22A23 belongs to a large family of transmembrane proteins that function as uniporters, symporters, and antiporters to transport organic ions across cell membranes (Jacobsson et al., 2007 [PubMed 17714910]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.55766029
2L-phenylalanine catabolic process (GO:0006559)5.55766029
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.05098764
4L-phenylalanine metabolic process (GO:0006558)5.05098764
5axonemal dynein complex assembly (GO:0070286)4.94844155
6axon ensheathment in central nervous system (GO:0032291)4.61805419
7central nervous system myelination (GO:0022010)4.61805419
8fatty acid elongation (GO:0030497)4.51387698
9aromatic amino acid family catabolic process (GO:0009074)4.38735878
10cilium or flagellum-dependent cell motility (GO:0001539)4.34820537
11alpha-linolenic acid metabolic process (GO:0036109)4.09515819
12bile acid biosynthetic process (GO:0006699)3.79913761
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.73918096
14glyoxylate metabolic process (GO:0046487)3.66071632
15motile cilium assembly (GO:0044458)3.58518810
16cysteine metabolic process (GO:0006534)3.54908864
17response to methylmercury (GO:0051597)3.54498325
18desmosome organization (GO:0002934)3.52201788
19very long-chain fatty acid metabolic process (GO:0000038)3.46799399
20vitamin transmembrane transport (GO:0035461)3.45355749
21cilium movement (GO:0003341)3.43225385
22cellular ketone body metabolic process (GO:0046950)3.40206159
23high-density lipoprotein particle remodeling (GO:0034375)3.39973988
24bile acid metabolic process (GO:0008206)3.36000134
25cytoskeletal anchoring at plasma membrane (GO:0007016)3.34711563
26tryptophan catabolic process (GO:0006569)3.34008326
27indole-containing compound catabolic process (GO:0042436)3.34008326
28indolalkylamine catabolic process (GO:0046218)3.34008326
29long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.31748844
30cholesterol biosynthetic process (GO:0006695)3.30903657
31glutamate metabolic process (GO:0006536)3.29818786
32fatty-acyl-CoA biosynthetic process (GO:0046949)3.29195068
33kynurenine metabolic process (GO:0070189)3.24428337
34lung epithelium development (GO:0060428)3.22720662
35embryonic retina morphogenesis in camera-type eye (GO:0060059)3.20957357
36coenzyme catabolic process (GO:0009109)3.20599805
37ethanol metabolic process (GO:0006067)3.20372355
38sulfur amino acid catabolic process (GO:0000098)3.19499009
39tryptophan metabolic process (GO:0006568)3.17059013
40tyrosine metabolic process (GO:0006570)3.16880737
41protein carboxylation (GO:0018214)3.14763069
42peptidyl-glutamic acid carboxylation (GO:0017187)3.14763069
43negative regulation of fibrinolysis (GO:0051918)3.13646636
44epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.13355660
45primary alcohol catabolic process (GO:0034310)3.11325702
46axon ensheathment (GO:0008366)3.09754965
47ensheathment of neurons (GO:0007272)3.09754965
48regulation of fibrinolysis (GO:0051917)3.09274206
49myelination (GO:0042552)3.08892928
50cholesterol efflux (GO:0033344)3.08663037
51reverse cholesterol transport (GO:0043691)3.05378310
52aromatic amino acid family metabolic process (GO:0009072)3.02415200
53urea cycle (GO:0000050)3.02031670
54urea metabolic process (GO:0019627)3.02031670
55regulation of cholesterol esterification (GO:0010872)3.01144422
56plasma lipoprotein particle clearance (GO:0034381)2.98794439
57hemidesmosome assembly (GO:0031581)2.98456736
58short-chain fatty acid metabolic process (GO:0046459)2.96655540
59sodium ion export (GO:0071436)2.95281478
60ketone body metabolic process (GO:1902224)2.92652036
61multicellular organismal water homeostasis (GO:0050891)2.92087826
62sodium ion homeostasis (GO:0055078)2.90309611
63acyl-CoA biosynthetic process (GO:0071616)2.89628129
64thioester biosynthetic process (GO:0035384)2.89628129
65pyrimidine nucleobase catabolic process (GO:0006208)2.87059307
66nitrogen cycle metabolic process (GO:0071941)2.86963005
67sterol biosynthetic process (GO:0016126)2.86144757
68regulation of triglyceride catabolic process (GO:0010896)2.85637774
69fatty-acyl-CoA metabolic process (GO:0035337)2.85470688
70protein-lipid complex remodeling (GO:0034368)2.84445118
71macromolecular complex remodeling (GO:0034367)2.84445118
72plasma lipoprotein particle remodeling (GO:0034369)2.84445118
73acetyl-CoA metabolic process (GO:0006084)2.84149403
74cerebellar granule cell differentiation (GO:0021707)2.83703195
75complement activation, alternative pathway (GO:0006957)2.83495292
76alpha-amino acid catabolic process (GO:1901606)2.82895028
77triglyceride homeostasis (GO:0070328)2.82577753
78acylglycerol homeostasis (GO:0055090)2.82577753
79drug catabolic process (GO:0042737)2.81142272
80heme transport (GO:0015886)2.80787272
81fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.80697493
82regulation of protein activation cascade (GO:2000257)2.78104601
83negative regulation of sterol transport (GO:0032372)2.75868273
84negative regulation of cholesterol transport (GO:0032375)2.75868273
85long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.75561900
86regulation of cholesterol biosynthetic process (GO:0045540)2.75008920
87cellular sodium ion homeostasis (GO:0006883)2.74304835
88peptidyl-tyrosine autophosphorylation (GO:0038083)2.73224570
89gamma-aminobutyric acid transport (GO:0015812)2.71790125
90negative regulation of neurotransmitter secretion (GO:0046929)2.71072301
91regulation of bile acid biosynthetic process (GO:0070857)2.70458749
92cellular amino acid catabolic process (GO:0009063)2.68523574
93phospholipid efflux (GO:0033700)2.68248952
94regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.68247464
95dicarboxylic acid biosynthetic process (GO:0043650)2.67788444
96negative regulation of lipase activity (GO:0060192)2.67450893
97very-low-density lipoprotein particle assembly (GO:0034379)2.66325008
98regulation of cholesterol homeostasis (GO:2000188)2.66044423
99semaphorin-plexin signaling pathway (GO:0071526)2.65750346
100ethanol oxidation (GO:0006069)2.64525300
101cellular modified amino acid catabolic process (GO:0042219)2.63766846
102aspartate family amino acid catabolic process (GO:0009068)2.63640378
103dicarboxylic acid catabolic process (GO:0043649)2.63535976
104drug transmembrane transport (GO:0006855)2.62802995
105lysine metabolic process (GO:0006553)2.61365306
106lysine catabolic process (GO:0006554)2.61365306
107protein-lipid complex assembly (GO:0065005)2.61017456
108bile acid and bile salt transport (GO:0015721)2.60841384
109regulation of cholesterol metabolic process (GO:0090181)2.57332777
110cofactor catabolic process (GO:0051187)2.56769316
111intestinal cholesterol absorption (GO:0030299)2.56461271
112cholesterol metabolic process (GO:0008203)2.56377916
113thioester metabolic process (GO:0035383)2.56376215
114acyl-CoA metabolic process (GO:0006637)2.56376215
115surfactant homeostasis (GO:0043129)2.55817811
116regulation of complement activation (GO:0030449)2.54497941
117glycerophospholipid catabolic process (GO:0046475)2.54283225
118cholesterol homeostasis (GO:0042632)2.53096640
119layer formation in cerebral cortex (GO:0021819)2.52099837
120plasma lipoprotein particle assembly (GO:0034377)2.51930473
121apical protein localization (GO:0045176)2.51692363
122intestinal absorption (GO:0050892)2.51608066
123negative regulation of keratinocyte proliferation (GO:0010839)2.50731620
124sterol homeostasis (GO:0055092)2.50222659
125planar cell polarity pathway involved in neural tube closure (GO:0090179)2.49480222
126epithelial cilium movement (GO:0003351)2.49139273
127serine family amino acid catabolic process (GO:0009071)2.48684974
128iron coordination entity transport (GO:1901678)2.48399233
129establishment of skin barrier (GO:0061436)2.46425202
130regulation of water loss via skin (GO:0033561)2.46271054
131camera-type eye morphogenesis (GO:0048593)2.46247308
132cell migration in hindbrain (GO:0021535)2.45733268
133water homeostasis (GO:0030104)2.45547101
134cellular potassium ion homeostasis (GO:0030007)2.43669912
135bundle of His cell to Purkinje myocyte communication (GO:0086069)2.43555214
136regulation of apoptotic cell clearance (GO:2000425)2.42782428
137regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.41521008
138positive regulation of dendritic spine morphogenesis (GO:0061003)2.37946454
139asymmetric protein localization (GO:0008105)2.33717715
140synaptic vesicle docking involved in exocytosis (GO:0016081)2.33088453
141establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.32289477
142positive regulation of synapse maturation (GO:0090129)2.31804806
143establishment or maintenance of bipolar cell polarity (GO:0061245)2.29075366
144establishment or maintenance of apical/basal cell polarity (GO:0035088)2.29075366
145long-chain fatty acid biosynthetic process (GO:0042759)2.28971791
146epoxygenase P450 pathway (GO:0019373)2.26545090
147cell-cell junction maintenance (GO:0045217)2.26320286
148vocalization behavior (GO:0071625)2.26147891
149dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.25532302
150left/right pattern formation (GO:0060972)2.25196396
151neurotransmitter-gated ion channel clustering (GO:0072578)2.24687126
152one-carbon compound transport (GO:0019755)2.24675504
153chemical homeostasis within a tissue (GO:0048875)2.24498245
154cell communication involved in cardiac conduction (GO:0086065)2.22793516
155positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.17955538
156phosphate ion transmembrane transport (GO:0035435)2.16221017
157establishment of planar polarity (GO:0001736)2.16076763
158establishment of tissue polarity (GO:0007164)2.16076763
159ionotropic glutamate receptor signaling pathway (GO:0035235)2.14133381
160plasma lipoprotein particle organization (GO:0071827)2.13321350
161lateral sprouting from an epithelium (GO:0060601)2.11898278
162regulation of short-term neuronal synaptic plasticity (GO:0048172)2.11088185
163cell junction maintenance (GO:0034331)2.07609705
164actin filament capping (GO:0051693)2.07429187
165filopodium assembly (GO:0046847)2.07360575
166gap junction assembly (GO:0016264)2.07313794
167epithelial cell-cell adhesion (GO:0090136)2.07004556
168neuronal ion channel clustering (GO:0045161)2.06525522
169receptor recycling (GO:0001881)2.05678959
170protein-lipid complex subunit organization (GO:0071825)2.05217849
171establishment of apical/basal cell polarity (GO:0035089)2.03825320
172regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.03182364
173regulation of response to osmotic stress (GO:0047484)2.02355834
174regulation of fatty acid beta-oxidation (GO:0031998)2.01630525
175cellular response to prostaglandin stimulus (GO:0071379)2.00836582
176negative regulation of fatty acid transport (GO:2000192)2.00428688
177neuron recognition (GO:0008038)1.99930916
178low-density lipoprotein particle remodeling (GO:0034374)1.99251564
179polyol transport (GO:0015791)1.98561587
180proline metabolic process (GO:0006560)1.98206559

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.72974778
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.67362253
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.54674734
4* LXR_22158963_ChIP-Seq_LIVER_Mouse3.09647639
5PPARA_22158963_ChIP-Seq_LIVER_Mouse2.75632007
6EGR1_23403033_ChIP-Seq_LIVER_Mouse2.39835985
7GBX2_23144817_ChIP-Seq_PC3_Human2.36433710
8* FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.30135782
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.20543073
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.19714121
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.96229404
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.90583743
13CDX2_20551321_ChIP-Seq_CACO-2_Human1.86636115
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.80094456
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.79022673
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.78633593
17STAT6_21828071_ChIP-Seq_BEAS2B_Human1.73919556
18* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.73448883
19EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.70158522
20* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.69865434
21KDM2B_26808549_Chip-Seq_K562_Human1.68018322
22DROSHA_22980978_ChIP-Seq_HELA_Human1.67744372
23RNF2_18974828_ChIP-Seq_MESCs_Mouse1.64928048
24EZH2_18974828_ChIP-Seq_MESCs_Mouse1.64928048
25EZH2_22144423_ChIP-Seq_EOC_Human1.64485308
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.60856795
27* ESR1_21235772_ChIP-Seq_MCF-7_Human1.57395113
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.55851011
29* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55382103
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.55285135
31AR_21572438_ChIP-Seq_LNCaP_Human1.54662279
32TAF15_26573619_Chip-Seq_HEK293_Human1.54519578
33* EZH2_27294783_Chip-Seq_ESCs_Mouse1.52965980
34* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.52205047
35WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.51332094
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.49770154
37CLOCK_20551151_ChIP-Seq_293T_Human1.49305611
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.49108552
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.46586986
40LXR_22292898_ChIP-Seq_THP-1_Human1.45587997
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44994530
42SOX9_24532713_ChIP-Seq_HFSC_Mouse1.42354710
43* FOXA2_19822575_ChIP-Seq_HepG2_Human1.42301396
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.40931395
45RACK7_27058665_Chip-Seq_MCF-7_Human1.40372727
46CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.39358008
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37051730
48RUNX1_27514584_Chip-Seq_MCF-7_Human1.35858860
49* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.35202777
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.34603943
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.34327943
52CTCF_27219007_Chip-Seq_Bcells_Human1.34029858
53ZFP281_18757296_ChIP-ChIP_E14_Mouse1.31911707
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29990197
55* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28237325
56TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.28026126
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.27702375
58CREB1_26743006_Chip-Seq_LNCaP_Human1.26796849
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25836647
60FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25667347
61* REST_21632747_ChIP-Seq_MESCs_Mouse1.25597765
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.23549778
63KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23403445
64ZNF263_19887448_ChIP-Seq_K562_Human1.22788256
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22389533
66EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21373278
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20775488
68RARB_27405468_Chip-Seq_BRAIN_Mouse1.20663109
69* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20304052
70DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20222671
71SMC4_20622854_ChIP-Seq_HELA_Human1.18993304
72* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17457367
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16985884
74ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15948883
75* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.14597065
76* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.14597065
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11492269
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.11334952
79ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11265915
80* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11160342
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09789202
82* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08201959
83KLF5_25053715_ChIP-Seq_YYC3_Human1.07780881
84* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07239287
85AHR_22903824_ChIP-Seq_MCF-7_Human1.06758015
86REST_18959480_ChIP-ChIP_MESCs_Mouse1.06555867
87CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05868363
88HTT_18923047_ChIP-ChIP_STHdh_Human1.04693519
89* ESR2_21235772_ChIP-Seq_MCF-7_Human1.04028557
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03675701
91OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.02340117
92BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02045609
93ARNT_22903824_ChIP-Seq_MCF-7_Human1.00718764
94SOX2_21211035_ChIP-Seq_LN229_Gbm1.00680030
95ESR1_20079471_ChIP-ChIP_T-47D_Human1.00096742
96NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99514785
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99422615
98* RING1B_27294783_Chip-Seq_NPCs_Mouse0.99333710
99* SMAD4_21799915_ChIP-Seq_A2780_Human0.99135281
100KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99066145
101TRIM28_21343339_ChIP-Seq_HEK293_Human0.98926680
102CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98540320
103TCF4_18268006_ChIP-ChIP_LS174T_Human0.98374636
104* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.98357055
105* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97493282
106TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97412539
107* TP63_22573176_ChIP-Seq_HFKS_Human0.96910529
108* STAT3_23295773_ChIP-Seq_U87_Human0.96511688
109CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.95843925
110P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95501273
111* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.95363367
112MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.94263392
113ER_23166858_ChIP-Seq_MCF-7_Human0.93942909
114P300_19829295_ChIP-Seq_ESCs_Human0.93874992
115RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93854529
116SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93842864
117UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93301527
118ISL1_27105846_Chip-Seq_CPCs_Mouse0.92702919
119NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91951676
120SOX2_20726797_ChIP-Seq_SW620_Human0.91456014
121SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91283114
122AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91016324
123EP300_21415370_ChIP-Seq_HL-1_Mouse0.90747335
124PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90694375
125KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90662127
126* SMAD4_21741376_ChIP-Seq_HESCs_Human0.90227278
127* GATA2_19941826_ChIP-Seq_K562_Human0.89001685
128* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88834982
129PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.87148764
130ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86990372
131* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.86216178
132NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86210765
133* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85397960
134* GATA1_19941826_ChIP-Seq_K562_Human0.85357545
135TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85034853
136TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83485579
137PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83405206
138ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83050720
139STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.82136619
140FOXO3_23340844_ChIP-Seq_DLD1_Human0.82009589
141* SMAD4_21741376_ChIP-Seq_EPCs_Human0.81570858
142RING1B_27294783_Chip-Seq_ESCs_Mouse0.81506194
143* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.80014306
144AR_19668381_ChIP-Seq_PC3_Human0.79105902
145TCF4_23295773_ChIP-Seq_U87_Human0.78741991
146POU3F2_20337985_ChIP-ChIP_501MEL_Human0.77415682
147SMAD3_21741376_ChIP-Seq_HESCs_Human0.76386401
148P53_22127205_ChIP-Seq_FIBROBLAST_Human0.76246106
149MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.76000124

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.71814059
2MP0005360_urolithiasis4.94114452
3MP0005085_abnormal_gallbladder_physiolo4.24670489
4MP0005365_abnormal_bile_salt3.83560722
5MP0000566_synostosis3.70413714
6MP0008875_abnormal_xenobiotic_pharmacok3.58435096
7MP0005409_darkened_coat_color3.31219291
8MP0010234_abnormal_vibrissa_follicle2.92802862
9MP0003195_calcinosis2.71790154
10MP0003252_abnormal_bile_duct2.71320676
11MP0003806_abnormal_nucleotide_metabolis2.68424790
12MP0004270_analgesia2.52733804
13MP0000920_abnormal_myelination2.49908884
14MP0004264_abnormal_extraembryonic_tissu2.48421231
15MP0003329_amyloid_beta_deposits2.40265826
16MP0005083_abnormal_biliary_tract2.36866219
17MP0003690_abnormal_glial_cell2.28559253
18MP0010329_abnormal_lipoprotein_level2.21642395
19MP0004859_abnormal_synaptic_plasticity2.19971785
20MP0009840_abnormal_foam_cell2.19617902
21MP0003705_abnormal_hypodermis_morpholog2.18251189
22MP0002796_impaired_skin_barrier2.07562374
23MP0001666_abnormal_nutrient_absorption2.05982277
24MP0003880_abnormal_central_pattern2.02809798
25MP0005332_abnormal_amino_acid1.87292267
26MP0009780_abnormal_chondrocyte_physiolo1.80090176
27MP0002138_abnormal_hepatobiliary_system1.79759579
28MP0002098_abnormal_vibrissa_morphology1.79227571
29MP0002118_abnormal_lipid_homeostasis1.76576248
30MP0000678_abnormal_parathyroid_gland1.75933216
31MP0004885_abnormal_endolymph1.72123931
32MP0000604_amyloidosis1.68012058
33MP0003868_abnormal_feces_composition1.67989607
34MP0005377_hearing/vestibular/ear_phenot1.65086839
35MP0003878_abnormal_ear_physiology1.65086839
36MP0003879_abnormal_hair_cell1.61431091
37MP0003122_maternal_imprinting1.59596840
38MP0001486_abnormal_startle_reflex1.57367797
39MP0000537_abnormal_urethra_morphology1.57295127
40MP0002653_abnormal_ependyma_morphology1.56590380
41MP0003635_abnormal_synaptic_transmissio1.56324853
42MP0002822_catalepsy1.52390264
43MP0002064_seizures1.48462475
44MP0000383_abnormal_hair_follicle1.44425852
45MP0001849_ear_inflammation1.42099796
46MP0002249_abnormal_larynx_morphology1.41539711
47MP0002272_abnormal_nervous_system1.40189633
48MP0004043_abnormal_pH_regulation1.39904000
49MP0005248_abnormal_Harderian_gland1.38614784
50MP0003453_abnormal_keratinocyte_physiol1.38471928
51MP0000778_abnormal_nervous_system1.35461208
52MP0009745_abnormal_behavioral_response1.34533686
53MP0005501_abnormal_skin_physiology1.32337850
54MP0001188_hyperpigmentation1.30963209
55MP0005076_abnormal_cell_differentiation1.29788490
56MP0004272_abnormal_basement_membrane1.29313262
57MP0003634_abnormal_glial_cell1.27522707
58MP0002089_abnormal_postnatal_growth/wei1.25813404
59MP0002063_abnormal_learning/memory/cond1.23817012
60MP0002734_abnormal_mechanical_nocicepti1.21055634
61MP0005451_abnormal_body_composition1.20993172
62MP0005423_abnormal_somatic_nervous1.19805023
63MP0004019_abnormal_vitamin_homeostasis1.19422933
64MP0004782_abnormal_surfactant_physiolog1.18877941
65MP0003656_abnormal_erythrocyte_physiolo1.15869705
66MP0005584_abnormal_enzyme/coenzyme_acti1.15483491
67MP0000762_abnormal_tongue_morphology1.15334897
68MP0009046_muscle_twitch1.14336558
69MP0000609_abnormal_liver_physiology1.13947193
70MP0000462_abnormal_digestive_system1.13436912
71MP0003632_abnormal_nervous_system1.13318865
72MP0003191_abnormal_cellular_cholesterol1.12349844
73MP0004742_abnormal_vestibular_system1.09579962
74MP0002229_neurodegeneration1.08976295
75MP0001485_abnormal_pinna_reflex1.08729475
76MP0002572_abnormal_emotion/affect_behav1.05560653
77MP0003183_abnormal_peptide_metabolism1.05051308
78MP0000467_abnormal_esophagus_morphology1.04327428
79MP0003941_abnormal_skin_development1.04278070
80MP0010368_abnormal_lymphatic_system1.03964738
81MP0005257_abnormal_intraocular_pressure1.03361420
82MP0001529_abnormal_vocalization1.02869220
83MP0003566_abnormal_cell_adhesion1.00119783
84MP0002896_abnormal_bone_mineralization0.98674834
85MP0003633_abnormal_nervous_system0.98491710
86MP0005499_abnormal_olfactory_system0.97941552
87MP0005394_taste/olfaction_phenotype0.97941552
88MP0005275_abnormal_skin_tensile0.97802712
89MP0000534_abnormal_ureter_morphology0.97158346
90MP0003631_nervous_system_phenotype0.97096940
91MP0002735_abnormal_chemical_nociception0.96978744
92MP0004147_increased_porphyrin_level0.96111717
93MP0002254_reproductive_system_inflammat0.95647313
94MP0000955_abnormal_spinal_cord0.95598907
95MP0000579_abnormal_nail_morphology0.93364793
96MP0001440_abnormal_grooming_behavior0.93325916
97MP0004142_abnormal_muscle_tone0.91540413
98MP0000377_abnormal_hair_follicle0.85081972
99MP0001346_abnormal_lacrimal_gland0.84570396
100MP0005646_abnormal_pituitary_gland0.84427786
101MP0010678_abnormal_skin_adnexa0.84374646
102MP0002733_abnormal_thermal_nociception0.83921195
103MP0009643_abnormal_urine_homeostasis0.82951667
104MP0005408_hypopigmentation0.82877516
105MP0001984_abnormal_olfaction0.82541140
106MP0005386_behavior/neurological_phenoty0.82508543
107MP0004924_abnormal_behavior0.82508543
108MP0002066_abnormal_motor_capabilities/c0.81984160
109MP0010771_integument_phenotype0.81556749
110MP0001299_abnormal_eye_distance/0.81376850
111MP0003861_abnormal_nervous_system0.81291287
112MP0008789_abnormal_olfactory_epithelium0.81264836
113MP0002876_abnormal_thyroid_physiology0.80535225
114MP0002882_abnormal_neuron_morphology0.79791049
115MP0001216_abnormal_epidermal_layer0.79264235
116MP0001177_atelectasis0.77862030
117MP0002067_abnormal_sensory_capabilities0.77374330
118MP0005535_abnormal_body_temperature0.77198377
119MP0001661_extended_life_span0.77078619
120MP0005623_abnormal_meninges_morphology0.76950619
121MP0005551_abnormal_eye_electrophysiolog0.76726303
122MP0004811_abnormal_neuron_physiology0.76317605
123MP0001905_abnormal_dopamine_level0.76288360
124MP0004185_abnormal_adipocyte_glucose0.76057548
125MP0002152_abnormal_brain_morphology0.75908004
126MP0009053_abnormal_anal_canal0.75505373
127MP0002909_abnormal_adrenal_gland0.75009465
128MP0001664_abnormal_digestion0.74047171
129MP0001502_abnormal_circadian_rhythm0.73431620
130MP0002090_abnormal_vision0.73277063
131MP0002078_abnormal_glucose_homeostasis0.71707944
132MP0005187_abnormal_penis_morphology0.71458368
133MP0005319_abnormal_enzyme/_coenzyme0.70699595
134MP0004858_abnormal_nervous_system0.70166832
135MP0001756_abnormal_urination0.69681572
136MP0003950_abnormal_plasma_membrane0.69586612
137MP0004130_abnormal_muscle_cell0.69508955
138MP0005636_abnormal_mineral_homeostasis0.69245175
139MP0005670_abnormal_white_adipose0.68413846
140MP0002233_abnormal_nose_morphology0.67908396
141MP0003942_abnormal_urinary_system0.67685388
142MP0003115_abnormal_respiratory_system0.67141714
143MP0005666_abnormal_adipose_tissue0.66696886
144MP0008874_decreased_physiological_sensi0.65784631
145MP0003315_abnormal_perineum_morphology0.65064770
146MP0002557_abnormal_social/conspecific_i0.64808817
147MP0000639_abnormal_adrenal_gland0.64062268
148MP0002295_abnormal_pulmonary_circulatio0.63100669
149MP0001968_abnormal_touch/_nociception0.61985386
150MP0001970_abnormal_pain_threshold0.61698523
151MP0002069_abnormal_eating/drinking_beha0.59832104
152MP0001963_abnormal_hearing_physiology0.59581540
153MP0005167_abnormal_blood-brain_barrier0.59339087
154MP0001765_abnormal_ion_homeostasis0.58927902
155MP0008569_lethality_at_weaning0.58887742
156MP0001501_abnormal_sleep_pattern0.58701084
157MP0003075_altered_response_to0.58055208

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.48555081
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.30456266
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.20353051
4Deep venous thrombosis (HP:0002625)5.12964818
5Neurofibrillary tangles (HP:0002185)4.69423965
6Abnormal respiratory motile cilium morphology (HP:0005938)4.65445636
7Abnormal respiratory epithelium morphology (HP:0012253)4.65445636
8Abnormal respiratory motile cilium physiology (HP:0012261)4.49681246
9Abnormal ciliary motility (HP:0012262)4.46011303
10Xanthomatosis (HP:0000991)4.40156982
11Absent/shortened dynein arms (HP:0200106)4.38367038
12Dynein arm defect of respiratory motile cilia (HP:0012255)4.38367038
13Rhinitis (HP:0012384)4.19987718
14Hyperlipoproteinemia (HP:0010980)4.09027168
15Prolonged partial thromboplastin time (HP:0003645)4.00505874
16Abnormality of monocarboxylic acid metabolism (HP:0010996)3.94446380
17Cerebral inclusion bodies (HP:0100314)3.82393561
18Chronic bronchitis (HP:0004469)3.72116331
19Hypobetalipoproteinemia (HP:0003563)3.71357341
20Degeneration of the lateral corticospinal tracts (HP:0002314)3.62362701
21Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.62362701
22Abnormality of the corticospinal tract (HP:0002492)3.46695331
23Epidermoid cyst (HP:0200040)3.31115454
24Ketosis (HP:0001946)3.15629350
25Nasal polyposis (HP:0100582)3.05567533
26Flat acetabular roof (HP:0003180)2.98944830
27Conjugated hyperbilirubinemia (HP:0002908)2.93351834
28Hyperactive renin-angiotensin system (HP:0000841)2.92039316
29Complement deficiency (HP:0004431)2.86678579
30Fat malabsorption (HP:0002630)2.85121153
31Supranuclear gaze palsy (HP:0000605)2.83774491
32Bronchomalacia (HP:0002780)2.75548271
33Hypoglycemic coma (HP:0001325)2.74311987
34Hyperammonemia (HP:0001987)2.74206735
35Abnormality of nail color (HP:0100643)2.73993760
36Sensory axonal neuropathy (HP:0003390)2.72461126
37Abnormality of serine family amino acid metabolism (HP:0010894)2.70780225
38Abnormality of glycine metabolism (HP:0010895)2.70780225
39Bronchiectasis (HP:0002110)2.69460059
40Hyperglycinemia (HP:0002154)2.68034967
41Hypolipoproteinemia (HP:0010981)2.67976088
42Ketoacidosis (HP:0001993)2.67858402
43Spastic gait (HP:0002064)2.67448060
44Intention tremor (HP:0002080)2.66741379
45Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.64349094
46Abnormality of the common coagulation pathway (HP:0010990)2.63928687
47Abnormality of the nasal mucosa (HP:0000433)2.62056575
48Myokymia (HP:0002411)2.59914773
49Termporal pattern (HP:0011008)2.55820623
50Insidious onset (HP:0003587)2.55820623
51Hyperventilation (HP:0002883)2.54710957
52Abnormality of aspartate family amino acid metabolism (HP:0010899)2.49983628
53Abnormality of glutamine family amino acid metabolism (HP:0010902)2.49197441
54Obstructive sleep apnea (HP:0002870)2.46444575
55Hypoglycemic seizures (HP:0002173)2.45486906
56Delayed CNS myelination (HP:0002188)2.41906989
57Abnormality of methionine metabolism (HP:0010901)2.40786897
58Hemorrhage of the eye (HP:0011885)2.40681624
59Acanthocytosis (HP:0001927)2.40257693
60Abnormality of sulfur amino acid metabolism (HP:0004339)2.39710321
61Right ventricular cardiomyopathy (HP:0011663)2.39703791
62Joint hemorrhage (HP:0005261)2.38689291
63Hyperinsulinemic hypoglycemia (HP:0000825)2.37138855
64Cerebral hemorrhage (HP:0001342)2.34127511
65Abnormal gallbladder morphology (HP:0012437)2.32521610
66Hypoalphalipoproteinemia (HP:0003233)2.29757186
67Abnormal gallbladder physiology (HP:0012438)2.27135510
68Cholecystitis (HP:0001082)2.27135510
69Neonatal short-limb short stature (HP:0008921)2.25691093
70Hyperbilirubinemia (HP:0002904)2.24427379
71Hypophosphatemic rickets (HP:0004912)2.23117504
72Hypercholesterolemia (HP:0003124)2.20681155
73Hyperkalemia (HP:0002153)2.19584710
74Atelectasis (HP:0100750)2.19406624
75Infertility (HP:0000789)2.19141217
76Aplasia of the phalanges of the hand (HP:0009802)2.17489806
77Aplasia involving bones of the extremities (HP:0009825)2.17489806
78Aplasia involving bones of the upper limbs (HP:0009823)2.17489806
79Abnormality of the intrinsic pathway (HP:0010989)2.16267776
80Rickets (HP:0002748)2.14452393
81Gout (HP:0001997)2.14336285
82Hyperglycinuria (HP:0003108)2.14330473
83Pheochromocytoma (HP:0002666)2.12750759
84Dysmetria (HP:0001310)2.12099579
85Morphological abnormality of the pyramidal tract (HP:0002062)2.11285026
86Male infertility (HP:0003251)2.11068990
87Bifid scrotum (HP:0000048)2.10465189
88Scanning speech (HP:0002168)2.10330379
89Abnormality of carpal bone ossification (HP:0006257)2.08954278
90Parakeratosis (HP:0001036)2.07908609
91Spastic paraparesis (HP:0002313)2.07736946
92Akinesia (HP:0002304)2.07312997
93Confusion (HP:0001289)2.07087848
94Steatorrhea (HP:0002570)2.06775656
95Arterial tortuosity (HP:0005116)2.05566349
96Symptomatic seizures (HP:0011145)2.04213250
97Cholelithiasis (HP:0001081)2.04195213
98Atrophic scars (HP:0001075)2.03147913
99Onion bulb formation (HP:0003383)2.02226761
100Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.02136709
101Vertebral arch anomaly (HP:0008438)2.00478793
102Glomerulonephritis (HP:0000099)1.99642471
103Skin nodule (HP:0200036)1.99550357
104Turricephaly (HP:0000262)1.99530799
105Alacrima (HP:0000522)1.97701629
106Ankle clonus (HP:0011448)1.96539626
107Amyloidosis (HP:0011034)1.96224844
108Irritability (HP:0000737)1.95216371
109Action tremor (HP:0002345)1.94782231
110Megalencephaly (HP:0001355)1.94620872
111Increased circulating renin level (HP:0000848)1.92953692
112Thin bony cortex (HP:0002753)1.91451091
113Alkalosis (HP:0001948)1.90456644
114Advanced eruption of teeth (HP:0006288)1.90077872
115Clonus (HP:0002169)1.88287993
116Germ cell neoplasia (HP:0100728)1.87565677
117Abnormality of chloride homeostasis (HP:0011422)1.86805672
118Spastic tetraparesis (HP:0001285)1.85877958
119Peripheral hypomyelination (HP:0007182)1.85495412
120Hepatoblastoma (HP:0002884)1.85272001
121Ulnar bowing (HP:0003031)1.83500134
122Vascular calcification (HP:0004934)1.82913580
123Abnormality of fatty-acid metabolism (HP:0004359)1.82517135
124Hepatocellular carcinoma (HP:0001402)1.81773295
125Metabolic acidosis (HP:0001942)1.80942374
126Abnormality of the gallbladder (HP:0005264)1.80625773
127Hypsarrhythmia (HP:0002521)1.80356661
128Abnormality of purine metabolism (HP:0004352)1.78503123
129Abnormality of the aortic arch (HP:0012303)1.77885482
130Paraparesis (HP:0002385)1.77199646
131Vascular tortuosity (HP:0004948)1.77179008
132Hypochromic microcytic anemia (HP:0004840)1.76972250
133Decreased circulating renin level (HP:0003351)1.76955700
134Poikilocytosis (HP:0004447)1.76911558
135Hypokalemic alkalosis (HP:0001949)1.76887891
136EEG with generalized epileptiform discharges (HP:0011198)1.76216902
137Shallow orbits (HP:0000586)1.76043896
138Protuberant abdomen (HP:0001538)1.75494146
139Delayed myelination (HP:0012448)1.74957346
140Ileus (HP:0002595)1.74709520
141Neuroendocrine neoplasm (HP:0100634)1.73833236
142Spontaneous abortion (HP:0005268)1.73761569
143Abnormality of the dental root (HP:0006486)1.73610452
144Taurodontia (HP:0000679)1.73610452
145Abnormality of permanent molar morphology (HP:0011071)1.73610452
146Laryngomalacia (HP:0001601)1.73518846
147Torticollis (HP:0000473)1.73288528
148Status epilepticus (HP:0002133)1.73111125
149Sensorimotor neuropathy (HP:0007141)1.72992928
150Recurrent otitis media (HP:0000403)1.72744509
151Abnormality of the distal phalanx of the thumb (HP:0009617)1.71768230
152Hyperparathyroidism (HP:0000843)1.69649228
153Abnormal ossification of hand bones (HP:0005921)1.67441759
154Abnormal hand bone ossification (HP:0010660)1.66748408
155Hyperaldosteronism (HP:0000859)1.65054559
156Abnormality of complement system (HP:0005339)1.63643312
157Lip pit (HP:0100267)1.63501240
158Hand muscle atrophy (HP:0009130)1.63014683
159Pili torti (HP:0003777)1.63011765
160Milia (HP:0001056)1.62392649
161Osteomalacia (HP:0002749)1.62333982
162Upper limb amyotrophy (HP:0009129)1.62111578
163Distal upper limb amyotrophy (HP:0007149)1.62111578
164Hyponatremia (HP:0002902)1.60016835
165Renal tubular acidosis (HP:0001947)1.59842915
166Abnormality of sodium homeostasis (HP:0010931)1.58706837
167Widely patent fontanelles and sutures (HP:0004492)1.57834238
168Abnormality of molar morphology (HP:0011070)1.57698334
169Abnormality of molar (HP:0011077)1.57698334
170Abnormality of the dental pulp (HP:0006479)1.56718924
171Broad metatarsal (HP:0001783)1.55177042
172Malnutrition (HP:0004395)1.54734671
173Hammertoe (HP:0001765)1.54687186
174Partial duplication of thumb phalanx (HP:0009944)1.52185583
175Systemic lupus erythematosus (HP:0002725)1.51474918
176Abnormality of renin-angiotensin system (HP:0000847)1.51394451
177Papillary thyroid carcinoma (HP:0002895)1.50789372
178Cutaneous finger syndactyly (HP:0010554)1.48514212
179Hypoplasia of dental enamel (HP:0006297)1.47281034
180Abnormality of the salivary glands (HP:0010286)1.45500665

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.11325239
2RIPK13.61440636
3OXSR13.22111260
4TRIB33.00601992
5EPHB12.80615599
6EPHA22.68259409
7EPHA42.62693420
8MARK12.44181460
9FGFR22.30651894
10WNK42.28302892
11CDK122.16112719
12INSRR2.08698280
13ICK2.07905455
14EEF2K2.07372560
15TNIK2.04416493
16NTRK12.03013595
17PKN11.92934795
18BCR1.85287354
19MET1.83658043
20CAMK1D1.77216858
21PAK61.70435662
22TYRO31.68229076
23MAP3K91.64910023
24DAPK21.60790096
25MAP3K21.60537473
26ERBB41.58102539
27SMG11.53826712
28FGFR31.47967687
29PDGFRA1.46962030
30PAK31.46259718
31PKN21.37750294
32SIK21.36750559
33CSNK1G21.34491913
34SIK11.34466904
35LATS21.32193855
36WNK11.30513495
37NTRK31.28385446
38KSR21.28363192
39CSNK1A1L1.28240073
40SGK4941.27463176
41SGK2231.27463176
42TAOK11.26426719
43UHMK11.25608568
44CSNK1G31.25336816
45PHKG11.25281623
46PHKG21.25281623
47BCKDK1.25049100
48EPHA31.24351553
49SGK21.24011588
50MAP2K41.23509634
51CDK191.21191421
52NTRK21.19343492
53MAP3K41.14241597
54DYRK1B1.14140965
55PRPF4B1.11337688
56MAPK151.10696558
57CDK51.09367726
58CSNK1G11.08038953
59CAMK2B1.05441304
60FGFR41.05391735
61AKT31.04985165
62DDR21.02505424
63TAOK31.02408446
64ERN11.02204918
65CASK0.97013127
66MTOR0.95142685
67MAPKAPK30.94462257
68MAP3K100.94087923
69MAP3K130.92352452
70ROCK20.91059976
71CAMK2G0.89982772
72LMTK20.87840258
73CAMK2D0.87553159
74RET0.86928644
75MINK10.86330141
76CDC42BPA0.82836672
77PTK20.81781180
78IRAK20.81514803
79CAMK1G0.79168806
80PDPK10.78295409
81CAMK2A0.78293177
82NEK60.78056890
83MARK20.77815486
84MAPKAPK50.76800931
85RPS6KA20.76273111
86MAPK130.75999104
87STK110.75341737
88BRD40.73932885
89STK380.73391436
90LIMK10.72609762
91FGR0.71599769
92PRKD30.71013181
93PRKCZ0.70987548
94PRKCQ0.69440771
95GSK3A0.69356228
96PRKAA20.67904135
97ERBB20.66021481
98DYRK20.65924278
99PRKCE0.64401072
100DMPK0.64338280
101KSR10.62989202
102MAP3K30.62807938
103MAP2K70.61427695
104MAP3K10.60910561
105LATS10.60795655
106PRKCH0.60230734
107PIK3CA0.59699037
108IRAK10.59078923
109FYN0.58045918
110MST1R0.57033892
111PTK60.56887909
112PNCK0.55385070
113MAP3K60.55335126
114MAP3K70.55164772
115MAPK100.54942045
116PRKD10.54761566
117PBK0.54203032
118CDK140.53749017
119PRKAA10.53184991
120PRKCG0.52219486
121EPHB20.51676331
122SGK10.51025683
123YES10.50670202
124STK240.48513308
125PDGFRB0.47712857
126CAMKK10.47331360
127BMX0.47231407
128HIPK20.47143671
129CDK150.45886380
130PRKACG0.45230385
131ROCK10.44655680
132ABL20.43823633
133SGK30.43823401
134FER0.43100202
135MAP2K10.42887593
136FGFR10.42670478
137ARAF0.42529538
138CDK60.41074278
139RPS6KB10.40865497
140MAPK80.38215337
141DYRK1A0.36917206
142ACVR1B0.36070261
143GSK3B0.35666288

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.52238784
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.21328511
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.95400305
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.63537693
5Steroid biosynthesis_Homo sapiens_hsa001002.60140458
6Butanoate metabolism_Homo sapiens_hsa006502.58309723
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.34090903
8Fatty acid elongation_Homo sapiens_hsa000622.26865021
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.25246442
10Arginine biosynthesis_Homo sapiens_hsa002202.17026586
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.07685169
12Tryptophan metabolism_Homo sapiens_hsa003802.02529409
13Sulfur metabolism_Homo sapiens_hsa009202.01876027
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.98071823
15Fatty acid degradation_Homo sapiens_hsa000711.88041607
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.84814578
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.79344304
18Fatty acid metabolism_Homo sapiens_hsa012121.78595706
19Histidine metabolism_Homo sapiens_hsa003401.76614825
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.67350882
21Complement and coagulation cascades_Homo sapiens_hsa046101.64197175
22Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.63705927
23Bile secretion_Homo sapiens_hsa049761.60006023
24Peroxisome_Homo sapiens_hsa041461.56525017
25Propanoate metabolism_Homo sapiens_hsa006401.55368228
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.54421216
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.51097393
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.49102201
29PPAR signaling pathway_Homo sapiens_hsa033201.47463172
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.43502951
31Chemical carcinogenesis_Homo sapiens_hsa052041.28327346
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.28042509
33beta-Alanine metabolism_Homo sapiens_hsa004101.27168152
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.21366593
35Vitamin B6 metabolism_Homo sapiens_hsa007501.20258249
36Retinol metabolism_Homo sapiens_hsa008301.19379489
37Carbohydrate digestion and absorption_Homo sapiens_hsa049731.15896616
38Notch signaling pathway_Homo sapiens_hsa043301.15565623
39ABC transporters_Homo sapiens_hsa020101.13631039
40Protein digestion and absorption_Homo sapiens_hsa049741.13345704
41Adherens junction_Homo sapiens_hsa045201.12287550
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08117059
43Long-term potentiation_Homo sapiens_hsa047201.06866144
44Mineral absorption_Homo sapiens_hsa049781.04542802
45Phenylalanine metabolism_Homo sapiens_hsa003601.04502275
46Tight junction_Homo sapiens_hsa045301.01947332
47Pyruvate metabolism_Homo sapiens_hsa006200.99567733
48Tyrosine metabolism_Homo sapiens_hsa003500.98849717
49Fat digestion and absorption_Homo sapiens_hsa049750.97454446
50Ether lipid metabolism_Homo sapiens_hsa005650.96108796
51ECM-receptor interaction_Homo sapiens_hsa045120.95956296
52Renin-angiotensin system_Homo sapiens_hsa046140.94407161
53Arginine and proline metabolism_Homo sapiens_hsa003300.94011715
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93492780
55Endometrial cancer_Homo sapiens_hsa052130.92901451
56GABAergic synapse_Homo sapiens_hsa047270.91962571
57Choline metabolism in cancer_Homo sapiens_hsa052310.90219509
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86727120
59Fructose and mannose metabolism_Homo sapiens_hsa000510.86531356
60ErbB signaling pathway_Homo sapiens_hsa040120.85737105
61Caffeine metabolism_Homo sapiens_hsa002320.85459472
62Fatty acid biosynthesis_Homo sapiens_hsa000610.83975875
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79792720
64AMPK signaling pathway_Homo sapiens_hsa041520.78983211
65Pancreatic secretion_Homo sapiens_hsa049720.78300670
66Glutamatergic synapse_Homo sapiens_hsa047240.75627170
67Axon guidance_Homo sapiens_hsa043600.74358393
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74174514
69Estrogen signaling pathway_Homo sapiens_hsa049150.73090344
70GnRH signaling pathway_Homo sapiens_hsa049120.72507638
71Starch and sucrose metabolism_Homo sapiens_hsa005000.71261866
72Selenocompound metabolism_Homo sapiens_hsa004500.70939714
73Glycerolipid metabolism_Homo sapiens_hsa005610.69190728
74Inositol phosphate metabolism_Homo sapiens_hsa005620.68488734
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68385729
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66653602
77Gap junction_Homo sapiens_hsa045400.66485728
78Vitamin digestion and absorption_Homo sapiens_hsa049770.65963543
79Amoebiasis_Homo sapiens_hsa051460.65941709
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65785965
81Insulin signaling pathway_Homo sapiens_hsa049100.65370551
82Insulin resistance_Homo sapiens_hsa049310.65094434
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64793422
84Melanogenesis_Homo sapiens_hsa049160.64552667
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.64461998
86Glucagon signaling pathway_Homo sapiens_hsa049220.63343981
87Staphylococcus aureus infection_Homo sapiens_hsa051500.63260041
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61939835
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61886187
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.60322975
91Hippo signaling pathway_Homo sapiens_hsa043900.60030255
92Glioma_Homo sapiens_hsa052140.59191427
93VEGF signaling pathway_Homo sapiens_hsa043700.58564455
94Prion diseases_Homo sapiens_hsa050200.57180738
95Folate biosynthesis_Homo sapiens_hsa007900.55989808
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.55786860
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55202539
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55028075
99Circadian rhythm_Homo sapiens_hsa047100.54484152
100Insulin secretion_Homo sapiens_hsa049110.54376791
101Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54141035
102Chronic myeloid leukemia_Homo sapiens_hsa052200.53568896
103Linoleic acid metabolism_Homo sapiens_hsa005910.52851159
104Focal adhesion_Homo sapiens_hsa045100.52109310
105cAMP signaling pathway_Homo sapiens_hsa040240.51600270
106mTOR signaling pathway_Homo sapiens_hsa041500.51318044
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.50743799
108Cocaine addiction_Homo sapiens_hsa050300.50141932
109Morphine addiction_Homo sapiens_hsa050320.49654305
110Ovarian steroidogenesis_Homo sapiens_hsa049130.48963030
111Lysine degradation_Homo sapiens_hsa003100.45967436
112Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45320829
113Circadian entrainment_Homo sapiens_hsa047130.44926722
114Synaptic vesicle cycle_Homo sapiens_hsa047210.42685773
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42371058
116Serotonergic synapse_Homo sapiens_hsa047260.39493826
117Cholinergic synapse_Homo sapiens_hsa047250.39231157
118Dorso-ventral axis formation_Homo sapiens_hsa043200.38989467
119Carbon metabolism_Homo sapiens_hsa012000.38540564
120Nicotine addiction_Homo sapiens_hsa050330.38274353
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37848524
122Salivary secretion_Homo sapiens_hsa049700.37798980
123Type II diabetes mellitus_Homo sapiens_hsa049300.37790079
124Glutathione metabolism_Homo sapiens_hsa004800.37549755
125Biosynthesis of amino acids_Homo sapiens_hsa012300.36062302
126Dopaminergic synapse_Homo sapiens_hsa047280.34996870
127Gastric acid secretion_Homo sapiens_hsa049710.32890281
128Olfactory transduction_Homo sapiens_hsa047400.32144215
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.31411671
130Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.30796131
131Sphingolipid metabolism_Homo sapiens_hsa006000.30777360
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.30198082
133Long-term depression_Homo sapiens_hsa047300.29908490
134Metabolic pathways_Homo sapiens_hsa011000.29658753
135Cyanoamino acid metabolism_Homo sapiens_hsa004600.28635584
136Thyroid hormone synthesis_Homo sapiens_hsa049180.28171566
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28163980
138Amphetamine addiction_Homo sapiens_hsa050310.27367905
139Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.26976532
140Renin secretion_Homo sapiens_hsa049240.26334375
141Aldosterone synthesis and secretion_Homo sapiens_hsa049250.24069524

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