ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	drug catabolic process (GO:0042737)	5.59144842
2	exogenous drug catabolic process (GO:0042738)	5.36263194
3	tryptophan catabolic process (GO:0006569)	5.05020732
4	indole-containing compound catabolic process (GO:0042436)	5.05020732
5	indolalkylamine catabolic process (GO:0046218)	5.05020732
6	indolalkylamine metabolic process (GO:0006586)	4.50853635
7	tryptophan metabolic process (GO:0006568)	4.34835287
8	oxidative demethylation (GO:0070989)	4.31142658
9	cellular ketone body metabolic process (GO:0046950)	4.25102997
10	aromatic amino acid family catabolic process (GO:0009074)	4.17532656
11	kynurenine metabolic process (GO:0070189)	4.15362694
12	omega-hydroxylase P450 pathway (GO:0097267)	4.11129782
13	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.06969671
14	glyoxylate metabolic process (GO:0046487)	3.87667451
15	ketone body metabolic process (GO:1902224)	3.85411681
16	epoxygenase P450 pathway (GO:0019373)	3.85335096
17	L-methionine salvage (GO:0071267)	3.72370297
18	L-methionine biosynthetic process (GO:0071265)	3.72370297
19	amino acid salvage (GO:0043102)	3.72370297
20	DNA double-strand break processing (GO:0000729)	3.71769765
21	amine catabolic process (GO:0009310)	3.58881251
22	cellular biogenic amine catabolic process (GO:0042402)	3.58881251
23	arginine catabolic process (GO:0006527)	3.53578146
24	drug metabolic process (GO:0017144)	3.51065437
25	signal peptide processing (GO:0006465)	3.43604879
26	S-adenosylmethionine metabolic process (GO:0046500)	3.43546978
27	detection of light stimulus involved in sensory perception (GO:0050962)	3.41406354
28	detection of light stimulus involved in visual perception (GO:0050908)	3.41406354
29	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.33975704
30	aromatic amino acid family metabolic process (GO:0009072)	3.31917074
31	photoreceptor cell maintenance (GO:0045494)	3.30534524
32	piRNA metabolic process (GO:0034587)	3.30497740
33	response to pheromone (GO:0019236)	3.27891996
34	bile acid biosynthetic process (GO:0006699)	3.27188531
35	methionine biosynthetic process (GO:0009086)	3.22312194
36	indole-containing compound metabolic process (GO:0042430)	3.22111641
37	L-phenylalanine catabolic process (GO:0006559)	3.19108570
38	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.19108570
39	dopamine transport (GO:0015872)	3.19034636
40	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.18921978
41	cellular response to sterol (GO:0036315)	3.18120202
42	benzene-containing compound metabolic process (GO:0042537)	3.17530402
43	neural tube formation (GO:0001841)	3.17235847
44	behavioral response to ethanol (GO:0048149)	3.15115699
45	behavioral response to nicotine (GO:0035095)	3.13974567
46	flavonoid metabolic process (GO:0009812)	3.11415874
47	alkaloid metabolic process (GO:0009820)	3.10265838
48	L-fucose catabolic process (GO:0042355)	3.08527050
49	fucose catabolic process (GO:0019317)	3.08527050
50	L-fucose metabolic process (GO:0042354)	3.08527050
51	response to nitrosative stress (GO:0051409)	3.08007665
52	regulation of triglyceride catabolic process (GO:0010896)	3.05633263
53	cellular glucuronidation (GO:0052695)	3.03742772
54	negative regulation of protein activation cascade (GO:2000258)	3.02628792
55	serine family amino acid catabolic process (GO:0009071)	3.02323767
56	protein K11-linked deubiquitination (GO:0035871)	3.02298829
57	regulation of hippo signaling (GO:0035330)	3.01801980
58	regulation of protein activation cascade (GO:2000257)	2.94545146
59	glucuronate metabolic process (GO:0019585)	2.94209020
60	uronic acid metabolic process (GO:0006063)	2.94209020
61	arginine metabolic process (GO:0006525)	2.90919321
62	methionine metabolic process (GO:0006555)	2.90642745
63	regulation of acrosome reaction (GO:0060046)	2.89702901
64	negative regulation of complement activation (GO:0045916)	2.88521151
65	retinal cone cell development (GO:0046549)	2.87771553
66	gamma-aminobutyric acid transport (GO:0015812)	2.86371842
67	cilium or flagellum-dependent cell motility (GO:0001539)	2.86084334
68	C4-dicarboxylate transport (GO:0015740)	2.84934843
69	complement activation, alternative pathway (GO:0006957)	2.84556417
70	regulation of complement activation (GO:0030449)	2.83888997
71	xenobiotic catabolic process (GO:0042178)	2.82964239
72	phenylpropanoid metabolic process (GO:0009698)	2.81000687
73	regulation of meiosis I (GO:0060631)	2.80627911
74	alpha-amino acid catabolic process (GO:1901606)	2.79641058
75	reflex (GO:0060004)	2.79432741
76	tachykinin receptor signaling pathway (GO:0007217)	2.76652056
77	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.75449346
78	aspartate family amino acid catabolic process (GO:0009068)	2.73657468
79	regulation of hexokinase activity (GO:1903299)	2.72413785
80	regulation of glucokinase activity (GO:0033131)	2.72413785
81	coenzyme catabolic process (GO:0009109)	2.70779725
82	protein prenylation (GO:0018342)	2.67040845
83	prenylation (GO:0097354)	2.67040845
84	pyrimidine nucleobase catabolic process (GO:0006208)	2.65265526
85	auditory receptor cell stereocilium organization (GO:0060088)	2.64514858
86	bile acid metabolic process (GO:0008206)	2.63952259
87	high-density lipoprotein particle remodeling (GO:0034375)	2.63329867
88	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.58206498
89	imidazole-containing compound metabolic process (GO:0052803)	2.57770158
90	glycine metabolic process (GO:0006544)	2.56114241
91	reverse cholesterol transport (GO:0043691)	2.55466678
92	branched-chain amino acid catabolic process (GO:0009083)	2.54296354
93	axoneme assembly (GO:0035082)	2.53856862
94	dicarboxylic acid catabolic process (GO:0043649)	2.52799110
95	double-strand break repair via homologous recombination (GO:0000724)	2.52190141
96	recombinational repair (GO:0000725)	2.51546029
97	replication fork processing (GO:0031297)	2.51509594
98	inner ear receptor stereocilium organization (GO:0060122)	2.50458404
99	DNA methylation involved in gamete generation (GO:0043046)	2.48815059
100	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.47735297

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.27781261
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.19895030
3	VDR_22108803_ChIP-Seq_LS180_Human	3.19344037
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.80722877
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.78661754
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.77616800
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.71284468
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.67636866
9	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.29566864
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.29100565
11	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.23026919
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.22781489
13	P300_19829295_ChIP-Seq_ESCs_Human	2.19229030
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.17703017
15	* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.09889311
16	FUS_26573619_Chip-Seq_HEK293_Human	2.05744616
17	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.04062081
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.98664658
19	EWS_26573619_Chip-Seq_HEK293_Human	1.96041376
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.95188281
21	BCAT_22108803_ChIP-Seq_LS180_Human	1.92619429
22	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.92393431
23	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.89025429
24	STAT3_23295773_ChIP-Seq_U87_Human	1.88193240
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.80417791
26	SMAD4_21799915_ChIP-Seq_A2780_Human	1.80087596
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.77727593
28	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.74196100
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.71220263
30	CBP_20019798_ChIP-Seq_JUKART_Human	1.71220263
31	TCF4_23295773_ChIP-Seq_U87_Human	1.71220074
32	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.63770839
33	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.61076194
34	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.58824257
35	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.57984423
36	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.54131037
37	AR_25329375_ChIP-Seq_VCAP_Human	1.53882429
38	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.52222007
39	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.49906617
40	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.49859596
41	TCF4_22108803_ChIP-Seq_LS180_Human	1.49078856
42	EZH2_22144423_ChIP-Seq_EOC_Human	1.48511359
43	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.47134581
44	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.46025104
45	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.45131857
46	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.44045102
47	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.43904032
48	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.43370730
49	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.43370730
50	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.40701979
51	NANOG_19829295_ChIP-Seq_ESCs_Human	1.39002976
52	SOX2_19829295_ChIP-Seq_ESCs_Human	1.39002976
53	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37246058
54	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.35626182
55	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.34275989
56	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.32095641
57	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.31628769
58	RUNX2_22187159_ChIP-Seq_PCA_Human	1.30242625
59	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.29757632
60	IRF1_19129219_ChIP-ChIP_H3396_Human	1.27671939
61	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.27570471
62	TP53_22573176_ChIP-Seq_HFKS_Human	1.27131614
63	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.25292371
64	AR_21572438_ChIP-Seq_LNCaP_Human	1.24745073
65	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.23945653
66	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.23576398
67	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.22618662
68	CDX2_22108803_ChIP-Seq_LS180_Human	1.22409330
69	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.21670129
70	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.21630633
71	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.21602137
72	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.20339039
73	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.18435430
74	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.14764454
75	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.14764454
76	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.13503441
77	* PRDM14_20953172_ChIP-Seq_ESCs_Human	1.12961625
78	P53_22387025_ChIP-Seq_ESCs_Mouse	1.12937751
79	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.11405892
80	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.10839541
81	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.09307525
82	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.09024150
83	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08507272
84	TP53_16413492_ChIP-PET_HCT116_Human	1.08027265
85	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.07149650
86	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.06619598
87	P300_18555785_Chip-Seq_ESCs_Mouse	1.05859147
88	AR_20517297_ChIP-Seq_VCAP_Human	1.05784169
89	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.05072643
90	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.03662762
91	NCOR_22424771_ChIP-Seq_293T_Human	1.01034264
92	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00994218
93	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.00828794
94	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.99805876
95	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.98963475
96	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.98628563
97	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97694177
98	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.97677429
99	KDM2B_26808549_Chip-Seq_REH_Human	0.97344905
100	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.96449612

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	5.22175391
2	MP0005085_abnormal_gallbladder_physiolo	2.90120786
3	MP0005551_abnormal_eye_electrophysiolog	2.69770050
4	MP0003646_muscle_fatigue	2.66285099
5	MP0002138_abnormal_hepatobiliary_system	2.65288145
6	MP0000569_abnormal_digit_pigmentation	2.63710636
7	MP0008057_abnormal_DNA_replication	2.63236579
8	MP0004147_increased_porphyrin_level	2.53911591
9	MP0008877_abnormal_DNA_methylation	2.50643337
10	MP0008875_abnormal_xenobiotic_pharmacok	2.49289199
11	MP0002139_abnormal_hepatobiliary_system	2.40428491
12	MP0005360_urolithiasis	2.31188340
13	MP0005365_abnormal_bile_salt	2.31109719
14	MP0003252_abnormal_bile_duct	2.31064127
15	MP0001968_abnormal_touch/_nociception	2.12443740
16	MP0001501_abnormal_sleep_pattern	2.07369728
17	MP0002736_abnormal_nociception_after	2.03822232
18	MP0002102_abnormal_ear_morphology	2.03491662
19	MP0002876_abnormal_thyroid_physiology	2.02837849
20	MP0005253_abnormal_eye_physiology	1.80741233
21	MP0009046_muscle_twitch	1.76822530
22	MP0008872_abnormal_physiological_respon	1.76678189
23	MP0000372_irregular_coat_pigmentation	1.76259824
24	MP0009697_abnormal_copulation	1.76200235
25	MP0005646_abnormal_pituitary_gland	1.62560457
26	MP0003718_maternal_effect	1.61006760
27	MP0003950_abnormal_plasma_membrane	1.59811194
28	MP0006276_abnormal_autonomic_nervous	1.59538373
29	MP0001764_abnormal_homeostasis	1.57749832
30	MP0004043_abnormal_pH_regulation	1.56699881
31	MP0005645_abnormal_hypothalamus_physiol	1.53843626
32	MP0003136_yellow_coat_color	1.52508491
33	MP0002638_abnormal_pupillary_reflex	1.51483852
34	MP0010329_abnormal_lipoprotein_level	1.50801414
35	MP0002837_dystrophic_cardiac_calcinosis	1.47622257
36	MP0000427_abnormal_hair_cycle	1.46025954
37	MP0009745_abnormal_behavioral_response	1.45876080
38	MP0001984_abnormal_olfaction	1.43080466
39	MP0001986_abnormal_taste_sensitivity	1.43004171
40	MP0002938_white_spotting	1.41909319
41	MP0002735_abnormal_chemical_nociception	1.40431197
42	MP0005670_abnormal_white_adipose	1.39915587
43	MP0001486_abnormal_startle_reflex	1.38123378
44	MP0005167_abnormal_blood-brain_barrier	1.34395086
45	MP0003880_abnormal_central_pattern	1.34349563
46	MP0005395_other_phenotype	1.33215913
47	MP0002168_other_aberrant_phenotype	1.32224932
48	MP0003787_abnormal_imprinting	1.29918055
49	MP0006072_abnormal_retinal_apoptosis	1.29740584
50	MP0008058_abnormal_DNA_repair	1.28567093
51	MP0006292_abnormal_olfactory_placode	1.28109617
52	MP0005332_abnormal_amino_acid	1.22771459
53	MP0010386_abnormal_urinary_bladder	1.21989221
54	MP0002272_abnormal_nervous_system	1.21152982
55	MP0001485_abnormal_pinna_reflex	1.20888398
56	MP0003868_abnormal_feces_composition	1.15611856
57	MP0005386_behavior/neurological_phenoty	1.11812447
58	MP0004924_abnormal_behavior	1.11812447
59	MP0009780_abnormal_chondrocyte_physiolo	1.11260145
60	MP0001666_abnormal_nutrient_absorption	1.04629851
61	MP0008775_abnormal_heart_ventricle	1.00988980
62	MP0005266_abnormal_metabolism	0.99574317
63	MP0000383_abnormal_hair_follicle	0.93781271
64	MP0002733_abnormal_thermal_nociception	0.93138546
65	MP0005410_abnormal_fertilization	0.92087979
66	MP0003045_fibrosis	0.89629588
67	MP0001970_abnormal_pain_threshold	0.88847210
68	MP0004215_abnormal_myocardial_fiber	0.88819867
69	MP0005195_abnormal_posterior_eye	0.88612572
70	MP0005174_abnormal_tail_pigmentation	0.86757358
71	MP0000631_abnormal_neuroendocrine_gland	0.86174994
72	MP0005171_absent_coat_pigmentation	0.86095287
73	MP0002067_abnormal_sensory_capabilities	0.85096639
74	MP0002572_abnormal_emotion/affect_behav	0.84065548
75	MP0002229_neurodegeneration	0.83857336
76	MP0004142_abnormal_muscle_tone	0.83278007
77	MP0001929_abnormal_gametogenesis	0.82883673
78	MP0003698_abnormal_male_reproductive	0.82136795
79	MP0002090_abnormal_vision	0.81587069
80	MP0001324_abnormal_eye_pigmentation	0.80955956
81	MP0002557_abnormal_social/conspecific_i	0.80798437
82	MP0002928_abnormal_bile_duct	0.80704144
83	MP0010094_abnormal_chromosome_stability	0.80318516
84	MP0002064_seizures	0.79148990
85	MP0002118_abnormal_lipid_homeostasis	0.78332020
86	MP0003633_abnormal_nervous_system	0.78254199
87	MP0002254_reproductive_system_inflammat	0.77194011
88	MP0005187_abnormal_penis_morphology	0.76719809
89	MP0001529_abnormal_vocalization	0.76135576
90	MP0000230_abnormal_systemic_arterial	0.75862503
91	MP0005408_hypopigmentation	0.75685879
92	MP0010368_abnormal_lymphatic_system	0.75361456
93	MP0005379_endocrine/exocrine_gland_phen	0.74148691
94	MP0003011_delayed_dark_adaptation	0.71904461
95	MP0005647_abnormal_sex_gland	0.71658561
96	MP0003137_abnormal_impulse_conducting	0.70327543
97	MP0002234_abnormal_pharynx_morphology	0.69823395
98	MP0003635_abnormal_synaptic_transmissio	0.68527135
99	MP0000538_abnormal_urinary_bladder	0.67812598
100	MP0005376_homeostasis/metabolism_phenot	0.67744792

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	4.36570284
2	Pancreatic cysts (HP:0001737)	4.01389723
3	Congenital stationary night blindness (HP:0007642)	3.51450590
4	Pancreatic fibrosis (HP:0100732)	3.47298426
5	True hermaphroditism (HP:0010459)	3.30897454
6	Abnormality of midbrain morphology (HP:0002418)	3.30195937
7	Molar tooth sign on MRI (HP:0002419)	3.30195937
8	Birth length less than 3rd percentile (HP:0003561)	3.28548366
9	Gaze-evoked nystagmus (HP:0000640)	3.18407417
10	Fair hair (HP:0002286)	3.13394240
11	Attenuation of retinal blood vessels (HP:0007843)	3.09200847
12	Abnormality of the renal cortex (HP:0011035)	3.07388916
13	Prolonged partial thromboplastin time (HP:0003645)	3.06579463
14	Nephronophthisis (HP:0000090)	3.04563483
15	Chronic hepatic failure (HP:0100626)	3.00096766
16	Abnormality of the renal medulla (HP:0100957)	2.82820051
17	Medial flaring of the eyebrow (HP:0010747)	2.81975648
18	Hypobetalipoproteinemia (HP:0003563)	2.75568163
19	Volvulus (HP:0002580)	2.54195419
20	Absent speech (HP:0001344)	2.53126914
21	Type II lissencephaly (HP:0007260)	2.52922616
22	Abolished electroretinogram (ERG) (HP:0000550)	2.49467299
23	Cystic liver disease (HP:0006706)	2.48146207
24	Bile duct proliferation (HP:0001408)	2.45528012
25	Abnormal biliary tract physiology (HP:0012439)	2.45528012
26	Keratoconus (HP:0000563)	2.44235472
27	Increased corneal curvature (HP:0100692)	2.44235472
28	Inability to walk (HP:0002540)	2.44189021
29	Intestinal atresia (HP:0011100)	2.40644291
30	Pendular nystagmus (HP:0012043)	2.37552896
31	Generalized hypopigmentation of hair (HP:0011358)	2.36907489
32	Thyroid-stimulating hormone excess (HP:0002925)	2.33452421
33	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.31982833
34	Hypothermia (HP:0002045)	2.31849767
35	Tubular atrophy (HP:0000092)	2.31419992
36	Protruding tongue (HP:0010808)	2.30947525
37	Congenital sensorineural hearing impairment (HP:0008527)	2.30802301
38	Decreased central vision (HP:0007663)	2.30493396
39	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.22602659
40	Congenital primary aphakia (HP:0007707)	2.21192666
41	Hyperglycinuria (HP:0003108)	2.21071729
42	Gait imbalance (HP:0002141)	2.20274276
43	Bony spicule pigmentary retinopathy (HP:0007737)	2.19344038
44	Progressive inability to walk (HP:0002505)	2.17971506
45	Renal cortical cysts (HP:0000803)	2.17759666
46	Febrile seizures (HP:0002373)	2.16809636
47	Lissencephaly (HP:0001339)	2.14566002
48	Ketosis (HP:0001946)	2.11566487
49	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.11358316
50	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.08014154
51	Abnormality of glycine metabolism (HP:0010895)	2.07998261
52	Abnormality of serine family amino acid metabolism (HP:0010894)	2.07998261
53	Complement deficiency (HP:0004431)	2.07633529
54	Stomach cancer (HP:0012126)	2.06766563
55	Intrahepatic cholestasis (HP:0001406)	2.04865915
56	Ketoacidosis (HP:0001993)	2.02191131
57	Tubulointerstitial nephritis (HP:0001970)	2.02151563
58	Large for gestational age (HP:0001520)	2.00738399
59	Abnormality of the labia minora (HP:0012880)	2.00678793
60	Congenital hepatic fibrosis (HP:0002612)	2.00116567
61	Hyperglycinemia (HP:0002154)	1.97938670
62	Hyperlipoproteinemia (HP:0010980)	1.97393334
63	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.96133698
64	Genital tract atresia (HP:0001827)	1.96041749
65	Widely spaced teeth (HP:0000687)	1.95380686
66	Nephrogenic diabetes insipidus (HP:0009806)	1.94481978
67	Optic nerve hypoplasia (HP:0000609)	1.94259685
68	Focal motor seizures (HP:0011153)	1.91133937
69	Focal seizures (HP:0007359)	1.88942179
70	Abnormality of alanine metabolism (HP:0010916)	1.88130840
71	Hyperalaninemia (HP:0003348)	1.88130840
72	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.88130840
73	Cerebellar dysplasia (HP:0007033)	1.87590798
74	Conjugated hyperbilirubinemia (HP:0002908)	1.87224722
75	Abnormality of macular pigmentation (HP:0008002)	1.86136470
76	Progressive cerebellar ataxia (HP:0002073)	1.84159160
77	Vaginal atresia (HP:0000148)	1.81754470
78	Furrowed tongue (HP:0000221)	1.80878615
79	Sclerocornea (HP:0000647)	1.80299511
80	Broad-based gait (HP:0002136)	1.79539724
81	Abnormality of methionine metabolism (HP:0010901)	1.79469078
82	Dialeptic seizures (HP:0011146)	1.78740348
83	Postaxial foot polydactyly (HP:0001830)	1.78415067
84	Abnormality of pyrimidine metabolism (HP:0004353)	1.77918079
85	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.77047499
86	Retinal dysplasia (HP:0007973)	1.74974569
87	Hypoplasia of the pons (HP:0012110)	1.74361510
88	Patellar aplasia (HP:0006443)	1.73820342
89	Pancreatic islet-cell hyperplasia (HP:0004510)	1.73188833
90	Abnormality of the pons (HP:0007361)	1.73029890
91	Proximal tubulopathy (HP:0000114)	1.72770050
92	Epidermoid cyst (HP:0200040)	1.72208373
93	Genetic anticipation (HP:0003743)	1.72078721
94	Methylmalonic aciduria (HP:0012120)	1.70729123
95	Central scotoma (HP:0000603)	1.70537208
96	Thyroiditis (HP:0100646)	1.69816674
97	Abnormality of the ileum (HP:0001549)	1.69801761
98	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.69201333
99	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.68685744
100	Tubulointerstitial abnormality (HP:0001969)	1.68526924

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.58753996
2	ACVR1B	3.79423784
3	BMPR1B	3.69409558
4	MAP4K2	3.08040839
5	CASK	2.98462840
6	ADRBK2	2.63569586
7	WNK3	2.44770241
8	NUAK1	2.27939306
9	TRIM28	2.23251866
10	ZAK	2.06675231
11	GRK1	1.94904978
12	STK38L	1.78849365
13	INSRR	1.78826204
14	MAPK13	1.77452870
15	DAPK2	1.68868959
16	MKNK2	1.58645064
17	TNIK	1.52099334
18	EIF2AK3	1.51896003
19	PINK1	1.49439635
20	TGFBR1	1.43746887
21	PIK3CG	1.42409469
22	BRSK2	1.40838452
23	TAOK3	1.39311867
24	LATS1	1.27549398
25	STK39	1.19517612
26	NTRK3	1.16225325
27	MAP3K4	1.16217480
28	BCR	1.14781527
29	ADRBK1	1.14554040
30	PAK3	1.11623615
31	MARK1	1.10975653
32	PLK2	1.10018194
33	AKT3	1.08310650
34	OXSR1	1.06825564
35	ERBB3	1.00029389
36	MST4	0.96990022
37	EPHA4	0.96973061
38	STK3	0.92539369
39	MKNK1	0.92439068
40	PRKCE	0.90298756
41	FGFR2	0.88747895
42	PRKCG	0.85484899
43	BCKDK	0.84552809
44	PTK2B	0.83117428
45	FER	0.79232042
46	TEC	0.76672283
47	PNCK	0.76495638
48	CAMKK2	0.74826022
49	CSNK1G1	0.72488804
50	PLK4	0.67508845
51	CCNB1	0.67021756
52	PKN1	0.66359803
53	PLK3	0.65922005
54	WEE1	0.63506188
55	WNK4	0.61786438
56	NME1	0.60692206
57	PRKAA2	0.59425733
58	CAMK2A	0.58048177
59	CSNK1G2	0.57516359
60	PDK2	0.57027777
61	CSNK1A1L	0.56520655
62	CSNK1G3	0.54652204
63	NLK	0.52654374
64	MELK	0.51372469
65	MAP2K7	0.49955896
66	IRAK1	0.49170516
67	TNK2	0.47589527
68	PIK3CA	0.47584069
69	MAPKAPK5	0.47101815
70	CAMK1G	0.45711417
71	PRKAA1	0.41439004
72	PLK1	0.40379483
73	DYRK2	0.39416964
74	CSNK1A1	0.38387188
75	TIE1	0.38152267
76	ATM	0.38146007
77	MAPKAPK3	0.37023089
78	VRK1	0.36762075
79	CSNK1D	0.35402291
80	PRKACA	0.35252242
81	EIF2AK1	0.34671259
82	CAMK1	0.34092574
83	IGF1R	0.33179550
84	MAP2K6	0.33170189
85	ITK	0.32811660
86	MAP2K1	0.31963592
87	BRD4	0.31577347
88	MARK3	0.30533126
89	PRKACB	0.29728640
90	FLT3	0.29373697
91	PRKG1	0.29225574
92	ATR	0.28687765
93	OBSCN	0.27949012
94	PRKACG	0.27941759
95	GRK5	0.27074541
96	STK38	0.25871578
97	SGK2	0.25291807
98	MUSK	0.24284957
99	PRKCB	0.24003443
100	PRKCA	0.23898072

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butanoate metabolism_Homo sapiens_hsa00650	3.21419652
2	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.98643312
3	Caffeine metabolism_Homo sapiens_hsa00232	2.77535208
4	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.71108897
5	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.62263455
6	Retinol metabolism_Homo sapiens_hsa00830	2.60357402
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.56203339
8	Tryptophan metabolism_Homo sapiens_hsa00380	2.48254474
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.46361402
10	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.35878016
11	Chemical carcinogenesis_Homo sapiens_hsa05204	2.25610126
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.20978569
13	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.17554947
14	Phototransduction_Homo sapiens_hsa04744	2.05161747
15	ABC transporters_Homo sapiens_hsa02010	2.04813990
16	Complement and coagulation cascades_Homo sapiens_hsa04610	2.03284385
17	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.00249070
18	Propanoate metabolism_Homo sapiens_hsa00640	1.95491198
19	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.89378344
20	Fatty acid degradation_Homo sapiens_hsa00071	1.88348423
21	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.78579633
22	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.64520620
23	Histidine metabolism_Homo sapiens_hsa00340	1.63580807
24	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.61189821
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.57572521
26	beta-Alanine metabolism_Homo sapiens_hsa00410	1.55507756
27	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.48055651
28	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.46596256
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.45508725
30	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.39233519
31	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.38795238
32	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.37602595
33	Peroxisome_Homo sapiens_hsa04146	1.37414178
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.31264534
35	Homologous recombination_Homo sapiens_hsa03440	1.31101883
36	Fanconi anemia pathway_Homo sapiens_hsa03460	1.28262617
37	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.27721187
38	Nicotine addiction_Homo sapiens_hsa05033	1.25104093
39	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.22408751
40	Arginine biosynthesis_Homo sapiens_hsa00220	1.19287423
41	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.17814243
42	Selenocompound metabolism_Homo sapiens_hsa00450	1.17341114
43	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.17209051
44	One carbon pool by folate_Homo sapiens_hsa00670	1.15463635
45	Tyrosine metabolism_Homo sapiens_hsa00350	1.11507617
46	Non-homologous end-joining_Homo sapiens_hsa03450	1.11385057
47	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.10434017
48	Ether lipid metabolism_Homo sapiens_hsa00565	1.08772970
49	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.05225411
50	Glycerolipid metabolism_Homo sapiens_hsa00561	0.97185989
51	Protein export_Homo sapiens_hsa03060	0.96774493
52	Lysine degradation_Homo sapiens_hsa00310	0.95028801
53	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.91466025
54	Fatty acid metabolism_Homo sapiens_hsa01212	0.86110876
55	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.86103644
56	Bile secretion_Homo sapiens_hsa04976	0.85880680
57	Basal transcription factors_Homo sapiens_hsa03022	0.84540625
58	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.83251311
59	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.82594380
60	Taste transduction_Homo sapiens_hsa04742	0.81920349
61	Olfactory transduction_Homo sapiens_hsa04740	0.76819169
62	Serotonergic synapse_Homo sapiens_hsa04726	0.73825175
63	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.73286488
64	Fat digestion and absorption_Homo sapiens_hsa04975	0.70200091
65	Arginine and proline metabolism_Homo sapiens_hsa00330	0.69665497
66	PPAR signaling pathway_Homo sapiens_hsa03320	0.67644635
67	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.65768323
68	Metabolic pathways_Homo sapiens_hsa01100	0.64035934
69	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.56537529
70	Morphine addiction_Homo sapiens_hsa05032	0.55892925
71	GABAergic synapse_Homo sapiens_hsa04727	0.55182970
72	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.54874901
73	Pyruvate metabolism_Homo sapiens_hsa00620	0.53993150
74	RNA polymerase_Homo sapiens_hsa03020	0.53702621
75	Circadian rhythm_Homo sapiens_hsa04710	0.52689694
76	Circadian entrainment_Homo sapiens_hsa04713	0.51169046
77	Fatty acid elongation_Homo sapiens_hsa00062	0.47791161
78	Phenylalanine metabolism_Homo sapiens_hsa00360	0.47683805
79	Glutamatergic synapse_Homo sapiens_hsa04724	0.46746160
80	Salivary secretion_Homo sapiens_hsa04970	0.45240671
81	Calcium signaling pathway_Homo sapiens_hsa04020	0.44914471
82	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.43326093
83	Sphingolipid metabolism_Homo sapiens_hsa00600	0.42638327
84	Insulin secretion_Homo sapiens_hsa04911	0.41934932
85	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.41351047
86	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.41200823
87	RNA degradation_Homo sapiens_hsa03018	0.40934375
88	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.40825414
89	Sulfur metabolism_Homo sapiens_hsa00920	0.40568128
90	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.40076031
91	Steroid biosynthesis_Homo sapiens_hsa00100	0.36833591
92	Regulation of autophagy_Homo sapiens_hsa04140	0.35518747
93	Purine metabolism_Homo sapiens_hsa00230	0.32241653
94	Mineral absorption_Homo sapiens_hsa04978	0.30552718
95	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.29371514
96	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.28874096
97	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.27601005
98	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.27188803
99	Glutathione metabolism_Homo sapiens_hsa00480	0.26199163
100	Long-term depression_Homo sapiens_hsa04730	0.18424354

SLC22A25

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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