SLC22A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.55988168
2definitive hemopoiesis (GO:0060216)5.95403972
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.93659804
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.93659804
5negative regulation of fibrinolysis (GO:0051918)5.73857786
6regulation of protein activation cascade (GO:2000257)5.64214195
7complement activation, alternative pathway (GO:0006957)5.42242222
8regulation of complement activation (GO:0030449)5.40297990
9regulation of fibrinolysis (GO:0051917)5.34694209
10valine metabolic process (GO:0006573)5.23850217
11aminoglycoside antibiotic metabolic process (GO:0030647)4.85896146
12negative regulation of phagocytosis (GO:0050765)4.84084105
13protein carboxylation (GO:0018214)4.81716019
14peptidyl-glutamic acid carboxylation (GO:0017187)4.81716019
15antigen processing and presentation of endogenous antigen (GO:0019883)4.78132799
16ethanol oxidation (GO:0006069)4.69164122
17L-phenylalanine metabolic process (GO:0006558)4.58640119
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.58640119
19L-phenylalanine catabolic process (GO:0006559)4.57645701
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.57645701
21regulation of cholesterol esterification (GO:0010872)4.46701537
22telomere maintenance via semi-conservative replication (GO:0032201)4.29671340
23primary alcohol catabolic process (GO:0034310)4.29126844
24viral transcription (GO:0019083)4.26307134
25phospholipid efflux (GO:0033700)4.26282824
26megakaryocyte development (GO:0035855)4.26238645
27platelet dense granule organization (GO:0060155)4.25252400
28fibrinolysis (GO:0042730)4.25127265
29DNA unwinding involved in DNA replication (GO:0006268)4.16522853
30negative regulation of protein activation cascade (GO:2000258)4.14660707
31very-low-density lipoprotein particle assembly (GO:0034379)4.12777658
32ethanol metabolic process (GO:0006067)4.10058053
33translational termination (GO:0006415)4.06402743
34regulation of plasminogen activation (GO:0010755)4.04427942
35antigen processing and presentation via MHC class Ib (GO:0002475)4.04229087
36cellular glucuronidation (GO:0052695)4.03994183
37positive regulation of B cell differentiation (GO:0045579)3.99031200
38DNA strand elongation involved in DNA replication (GO:0006271)3.98624212
39regulation of erythrocyte differentiation (GO:0045646)3.96729971
40negative regulation of lipase activity (GO:0060192)3.96565029
41triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.94999186
42glyoxylate metabolic process (GO:0046487)3.90857741
43intestinal cholesterol absorption (GO:0030299)3.90325382
44DNA deamination (GO:0045006)3.90139902
45desmosome organization (GO:0002934)3.86083250
46DNA strand elongation (GO:0022616)3.85347420
47plasma lipoprotein particle assembly (GO:0034377)3.85204446
48negative regulation of sterol transport (GO:0032372)3.83883356
49negative regulation of cholesterol transport (GO:0032375)3.83883356
50plasma lipoprotein particle remodeling (GO:0034369)3.83142606
51protein-lipid complex remodeling (GO:0034368)3.83142606
52macromolecular complex remodeling (GO:0034367)3.83142606
53exogenous drug catabolic process (GO:0042738)3.82884655
54necroptotic process (GO:0070266)3.82070042
55cholesterol efflux (GO:0033344)3.80870881
56uronic acid metabolic process (GO:0006063)3.77697777
57glucuronate metabolic process (GO:0019585)3.77697777
58high-density lipoprotein particle remodeling (GO:0034375)3.76711235
59drug catabolic process (GO:0042737)3.74223611
60epoxygenase P450 pathway (GO:0019373)3.73642021
61surfactant homeostasis (GO:0043129)3.65251376
62pentose-phosphate shunt (GO:0006098)3.64068484
63protein-lipid complex assembly (GO:0065005)3.63503821
64translational elongation (GO:0006414)3.63349407
65urea metabolic process (GO:0019627)3.63051715
66phenylpropanoid metabolic process (GO:0009698)3.61860147
67negative regulation of blood coagulation (GO:0030195)3.61145236
68negative regulation of hemostasis (GO:1900047)3.61145236
69negative regulation of erythrocyte differentiation (GO:0045647)3.56450774
70oxaloacetate metabolic process (GO:0006107)3.56269452
71triglyceride catabolic process (GO:0019433)3.55726513
72DNA replication initiation (GO:0006270)3.55678019
73secretory granule organization (GO:0033363)3.53760115
74telomere maintenance via recombination (GO:0000722)3.53369380
75flavonoid metabolic process (GO:0009812)3.53016869
76protein activation cascade (GO:0072376)3.49748035
77negative regulation of complement activation (GO:0045916)3.49021770
78triglyceride homeostasis (GO:0070328)3.48795960
79acylglycerol homeostasis (GO:0055090)3.48795960
80daunorubicin metabolic process (GO:0044597)3.48087196
81polyketide metabolic process (GO:0030638)3.48087196
82doxorubicin metabolic process (GO:0044598)3.48087196
83plasma lipoprotein particle clearance (GO:0034381)3.46815106
84positive regulation of gamma-delta T cell activation (GO:0046645)3.40891085
85antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.40784360
86SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.38777111
87reverse cholesterol transport (GO:0043691)3.38641695
88regulation of apoptotic cell clearance (GO:2000425)3.37415150
89fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.36878244
90ribosomal small subunit biogenesis (GO:0042274)3.36679272
91regulation of cholesterol homeostasis (GO:2000188)3.36552577
92negative regulation of wound healing (GO:0061045)3.36288793
93embryonic hemopoiesis (GO:0035162)3.35319618
94negative regulation of coagulation (GO:0050819)3.35035183
95bile acid metabolic process (GO:0008206)3.33328315
96tricarboxylic acid metabolic process (GO:0072350)3.31852644
97translesion synthesis (GO:0019985)3.29052504
98complement activation, classical pathway (GO:0006958)3.28865554
99cotranslational protein targeting to membrane (GO:0006613)3.28835586
100mitotic recombination (GO:0006312)3.27482829
101chemical homeostasis within a tissue (GO:0048875)3.27297396
102protein targeting to ER (GO:0045047)3.26694202
103omega-hydroxylase P450 pathway (GO:0097267)3.26632425
104drug metabolic process (GO:0017144)3.26618471
105urea cycle (GO:0000050)3.26109913
106nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.23520424
107positive regulation of megakaryocyte differentiation (GO:0045654)3.22953613
108NADPH regeneration (GO:0006740)3.22574354
109positive regulation of granulocyte differentiation (GO:0030854)3.21808726
110complement activation (GO:0006956)3.21802625
111plasma lipoprotein particle organization (GO:0071827)3.21152273
112nitrogen cycle metabolic process (GO:0071941)3.20549055
113telomere maintenance via telomere lengthening (GO:0010833)3.18885843
114regulation of sequestering of triglyceride (GO:0010889)3.18254666
115thrombin receptor signaling pathway (GO:0070493)3.16554142
116glutamate metabolic process (GO:0006536)3.15192592
117bile acid biosynthetic process (GO:0006699)3.14628547
118protein-lipid complex subunit organization (GO:0071825)3.13197518
119protein localization to endoplasmic reticulum (GO:0070972)3.11940992
120establishment of protein localization to endoplasmic reticulum (GO:0072599)3.11516210
121positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.11144312
122acute-phase response (GO:0006953)3.10536239
123acylglycerol catabolic process (GO:0046464)3.10031918
124neutral lipid catabolic process (GO:0046461)3.10031918
125succinate metabolic process (GO:0006105)3.09788119
126negative regulation of cell aging (GO:0090344)3.09454481
127low-density lipoprotein particle remodeling (GO:0034374)3.09243282
128mast cell activation (GO:0045576)3.07768352
129negative regulation of macrophage differentiation (GO:0045650)3.06585161
130tyrosine phosphorylation of STAT protein (GO:0007260)3.06551073
131cellular protein complex disassembly (GO:0043624)3.04952203
132hemidesmosome assembly (GO:0031581)3.03230503
133gap junction assembly (GO:0016264)3.01020679
134nucleotide-excision repair, DNA gap filling (GO:0006297)2.99750136
135positive regulation of erythrocyte differentiation (GO:0045648)2.99347364
136positive regulation of blood coagulation (GO:0030194)2.98954754
137positive regulation of hemostasis (GO:1900048)2.98954754
138retinal metabolic process (GO:0042574)2.97377302
139positive regulation of triglyceride lipase activity (GO:0061365)2.97289016
140positive regulation of lipoprotein lipase activity (GO:0051006)2.97289016
141renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.97054849
142positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.96740075
143fucose catabolic process (GO:0019317)2.96454622
144L-fucose metabolic process (GO:0042354)2.96454622
145L-fucose catabolic process (GO:0042355)2.96454622
146phospholipid homeostasis (GO:0055091)2.96195452
147response to mercury ion (GO:0046689)2.95833658
148regulation of humoral immune response (GO:0002920)2.95426227
149viral life cycle (GO:0019058)2.94782808
150T cell homeostasis (GO:0043029)2.93982737
151IMP biosynthetic process (GO:0006188)2.92703023
152primary alcohol metabolic process (GO:0034308)2.92442284
153bile acid and bile salt transport (GO:0015721)2.91260028
154alpha-linolenic acid metabolic process (GO:0036109)2.90458548
155DNA topological change (GO:0006265)2.89934393
156regulation of triglyceride catabolic process (GO:0010896)2.84910398
157aromatic amino acid family catabolic process (GO:0009074)2.84742883
158progesterone metabolic process (GO:0042448)2.84007618
159biotin metabolic process (GO:0006768)2.83914850
160lymphoid progenitor cell differentiation (GO:0002320)2.83671548
161IMP metabolic process (GO:0046040)2.82709250
1622-oxoglutarate metabolic process (GO:0006103)2.80570321
163fatty acid beta-oxidation (GO:0006635)2.79506697
164lipoprotein metabolic process (GO:0042157)2.79364829
165blood coagulation, intrinsic pathway (GO:0007597)2.78986557
166fatty acid transmembrane transport (GO:1902001)2.78354073
167protein complex disassembly (GO:0043241)2.77576998
168positive regulation of coagulation (GO:0050820)2.76716347
169negative regulation of granulocyte differentiation (GO:0030853)2.76481237
170negative regulation of lipid transport (GO:0032369)2.75566595
171cholesterol homeostasis (GO:0042632)2.75263650
172carnitine shuttle (GO:0006853)2.74591834
173mast cell activation involved in immune response (GO:0002279)2.73355335
174mast cell degranulation (GO:0043303)2.73355335
175carnitine transmembrane transport (GO:1902603)2.71883921
176regulation of necroptotic process (GO:0060544)2.71643096
177regulation of cholesterol biosynthetic process (GO:0045540)2.71455803
178sterol homeostasis (GO:0055092)2.71363500
179regulation of granulocyte differentiation (GO:0030852)2.68385778
180brown fat cell differentiation (GO:0050873)2.68126506
181translational initiation (GO:0006413)2.67159202
182programmed necrotic cell death (GO:0097300)2.66399310
183maturation of SSU-rRNA (GO:0030490)2.66348647
184positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.66235158
185pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.66149757
186regulation of gamma-delta T cell differentiation (GO:0045586)2.66115268
187pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.65517689
188angiogenesis involved in wound healing (GO:0060055)2.64496001
189regulation of necrotic cell death (GO:0010939)2.60198441
190protein localization to kinetochore (GO:0034501)2.60043587
191nuclear-transcribed mRNA catabolic process (GO:0000956)2.58538901
192lipid storage (GO:0019915)2.58284211
193oxygen transport (GO:0015671)2.58250402
194germ cell migration (GO:0008354)2.57884075
195pentose metabolic process (GO:0019321)2.57314939
196erythrocyte maturation (GO:0043249)2.53950803

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.97831004
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.81935364
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.74865707
4SCL_19346495_ChIP-Seq_HPC-7_Human4.55026862
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.70323627
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.61501915
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.42351777
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.25220938
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.02013778
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.96152367
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.82569298
12* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.81695851
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.74797021
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.73210501
15GATA1_22025678_ChIP-Seq_K562_Human2.66334209
16TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.62179143
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.61927412
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.59559528
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.53982307
20CLOCK_20551151_ChIP-Seq_293T_Human2.45801783
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.43505583
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.39911549
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.39074870
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.37680880
25* FOXA2_19822575_ChIP-Seq_HepG2_Human2.28501005
26ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.24923641
27VDR_21846776_ChIP-Seq_THP-1_Human2.13866402
28RARG_19884340_ChIP-ChIP_MEFs_Mouse2.11884937
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.09144335
30* LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.06785877
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.06518609
32ESR1_21235772_ChIP-Seq_MCF-7_Human2.03338713
33MYC_22102868_ChIP-Seq_BL_Human2.03152173
34ESR1_20079471_ChIP-ChIP_T-47D_Human2.02752985
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99483978
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.99204626
37* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.93081201
38CIITA_25753668_ChIP-Seq_RAJI_Human1.92838064
39CDX2_20551321_ChIP-Seq_CACO-2_Human1.91203252
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.89707907
41ZNF263_19887448_ChIP-Seq_K562_Human1.86876178
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.84223867
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.84132221
44* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.83940987
45PPAR_26484153_Chip-Seq_NCI-H1993_Human1.83476356
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.83342305
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.81154171
48FOXO3_23340844_ChIP-Seq_DLD1_Human1.80039773
49TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.75730552
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.74707096
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74010722
52EP300_21415370_ChIP-Seq_HL-1_Mouse1.73687516
53ERG_20887958_ChIP-Seq_HPC-7_Mouse1.71760677
54HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.71598075
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.70463079
56SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.68170718
57SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.68170718
58FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.67969428
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66488744
60VDR_24763502_ChIP-Seq_THP-1_Human1.65445568
61BP1_19119308_ChIP-ChIP_Hs578T_Human1.64383950
62SALL4_18804426_ChIP-ChIP_XEN_Mouse1.64242453
63FOXP3_21729870_ChIP-Seq_TREG_Human1.61459998
64FOXM1_23109430_ChIP-Seq_U2OS_Human1.61411528
65MYC_18358816_ChIP-ChIP_MESCs_Mouse1.60811636
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.60636525
67ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.58772526
68SOX2_27498859_Chip-Seq_STOMACH_Mouse1.58357460
69SPI1_23547873_ChIP-Seq_NB4_Human1.57065107
70SOX9_24532713_ChIP-Seq_HFSC_Mouse1.56805704
71E2F1_21310950_ChIP-Seq_MCF-7_Human1.56372200
72SOX2_20726797_ChIP-Seq_SW620_Human1.56246830
73IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.56114556
74* GATA1_19941827_ChIP-Seq_MEL_Mouse1.55982284
75CJUN_26792858_Chip-Seq_BT549_Human1.55805085
76RUNX1_22412390_ChIP-Seq_EML_Mouse1.55755926
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52497809
78PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49733390
79* HNF4A_19822575_ChIP-Seq_HepG2_Human1.49668653
80* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.48843383
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47673958
82GATA2_22383799_ChIP-Seq_G1ME_Mouse1.47028467
83MYB_26560356_Chip-Seq_TH2_Human1.44672722
84TCF7_22412390_ChIP-Seq_EML_Mouse1.44143478
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44104603
86TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.43851158
87VDR_23849224_ChIP-Seq_CD4+_Human1.41226774
88EST1_17652178_ChIP-ChIP_JURKAT_Human1.38413190
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.37800560
90ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.37565884
91AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.37220946
92MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.36501203
93NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36484270
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36484270
95PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.35878937
96* GATA4_25053715_ChIP-Seq_YYC3_Human1.35830283
97XRN2_22483619_ChIP-Seq_HELA_Human1.35627482
98PIAS1_25552417_ChIP-Seq_VCAP_Human1.35570687
99MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33444817
100CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.32874273
101NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.32860298
102BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32009129
103NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30461262
104FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30428856
105GATA6_25053715_ChIP-Seq_YYC3_Human1.29928311
106TCF4_18268006_ChIP-ChIP_LS174T_Human1.29785542
107TBX20_22328084_ChIP-Seq_HEART_Mouse1.29295308
108TBX20_22080862_ChIP-Seq_HEART_Mouse1.29295308
109P63_26484246_Chip-Seq_KERATINOCYTES_Human1.28444369
110MYB_26560356_Chip-Seq_TH1_Human1.28306766
111UTX_26944678_Chip-Seq_JUKART_Human1.28018145
112MYC_19079543_ChIP-ChIP_MESCs_Mouse1.27943806
113FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27807064
114FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.26297578
115* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25293628
116MAF_26560356_Chip-Seq_TH1_Human1.24510288
117HIF1A_21447827_ChIP-Seq_MCF-7_Human1.23451673
118RXR_22158963_ChIP-Seq_LIVER_Mouse1.22974512
119SRF_21415370_ChIP-Seq_HL-1_Mouse1.22508441
120CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22053135
121ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21887668
122KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.20462371
123ETS1_20019798_ChIP-Seq_JURKAT_Human1.19284158
124RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.19075191
125STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18721936
126NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18241583
127PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17770669
128HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14869324
129PPARA_22158963_ChIP-Seq_LIVER_Mouse1.13937588
130KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13804088
131HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.13765836
132EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13214503
133NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13159494
134FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12534979
135GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11601016
136ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11418450
137TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11277841
138CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.09268692
139BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08912020
140GABP_17652178_ChIP-ChIP_JURKAT_Human1.07919796
141GATA2_21666600_ChIP-Seq_HMVEC_Human1.07167623
142AHR_22903824_ChIP-Seq_MCF-7_Human1.05505588
143CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05237079
144TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03718520
145JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.03684678
146ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02773262
147ETS1_22383799_ChIP-Seq_G1ME_Mouse1.02572998
148SPI1_23127762_ChIP-Seq_K562_Human1.01546480
149* AR_21909140_ChIP-Seq_LNCAP_Human1.01428953
150CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99213306
151E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98841305
152TP53_18474530_ChIP-ChIP_U2OS_Human0.98098151
153GATA3_24758297_ChIP-Seq_MCF-7_Human0.96722288
154CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96187207
155SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95149185
156CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94657070
157HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94652690
158RUNX_20019798_ChIP-Seq_JUKART_Human0.94313734
159SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94220544
160* TP63_23658742_ChIP-Seq_EP156T_Human0.93552732
161GABP_19822575_ChIP-Seq_HepG2_Human0.93456269
162FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93107392
163STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92757062
164THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92259137
165ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90894695
166RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90591483
167NELFA_20434984_ChIP-Seq_ESCs_Mouse0.89202254
168RACK7_27058665_Chip-Seq_MCF-7_Human0.88873684
169PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.88290046
170CREB1_15753290_ChIP-ChIP_HEK293T_Human0.86823104
171IRF1_19129219_ChIP-ChIP_H3396_Human0.86707151
172FOXM1_26456572_ChIP-Seq_MCF-7_Human0.85933442
173GATA1_19941826_ChIP-Seq_K562_Human0.85711412
174Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85663772
175ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.85205462
176ARNT_22903824_ChIP-Seq_MCF-7_Human0.84591669
177KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.84431502
178NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.84011557
179GATA2_19941826_ChIP-Seq_K562_Human0.83618632
180SMAD3_21741376_ChIP-Seq_HESCs_Human0.83214633
181CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.82728326
182AR_21572438_ChIP-Seq_LNCaP_Human0.82527043
183RUNX1_27514584_Chip-Seq_MCF-7_Human0.80345744
184WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.75785910
185UBF1/2_26484160_Chip-Seq_HMECs_Human0.75654497
186CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.75273894
187TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.75034193
188PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.74958577
189ATF3_27146783_Chip-Seq_COLON_Human0.74956118
190FOXA1_25552417_ChIP-Seq_VCAP_Human0.74559457

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system5.03258867
2MP0001545_abnormal_hematopoietic_system3.74117111
3MP0005397_hematopoietic_system_phenotyp3.74117111
4MP0005670_abnormal_white_adipose3.24287476
5MP0003724_increased_susceptibility_to3.05168447
6MP0004147_increased_porphyrin_level2.87920400
7MP0008875_abnormal_xenobiotic_pharmacok2.78662219
8MP0004782_abnormal_surfactant_physiolog2.77240498
9MP0004808_abnormal_hematopoietic_stem2.67056516
10MP0005275_abnormal_skin_tensile2.61440107
11MP0004272_abnormal_basement_membrane2.59087535
12MP0003195_calcinosis2.55565973
13MP0008438_abnormal_cutaneous_collagen2.50166723
14MP0009840_abnormal_foam_cell2.45688580
15MP0000465_gastrointestinal_hemorrhage2.34559681
16MP0003252_abnormal_bile_duct2.34343746
17MP0004130_abnormal_muscle_cell2.32276617
18MP0003656_abnormal_erythrocyte_physiolo2.28393627
19MP0005666_abnormal_adipose_tissue2.27943980
20MP0005464_abnormal_platelet_physiology2.24028837
21MP0001666_abnormal_nutrient_absorption2.19624625
22MP0002139_abnormal_hepatobiliary_system2.10915713
23MP0001835_abnormal_antigen_presentation2.07663509
24MP0002166_altered_tumor_susceptibility1.91814030
25MP0003566_abnormal_cell_adhesion1.89686439
26MP0005451_abnormal_body_composition1.87458519
27MP0005174_abnormal_tail_pigmentation1.85798679
28MP0005365_abnormal_bile_salt1.84664540
29MP0009278_abnormal_bone_marrow1.84093069
30MP0006054_spinal_hemorrhage1.82800222
31MP0010094_abnormal_chromosome_stability1.79038722
32MP0005075_abnormal_melanosome_morpholog1.78053974
33MP0003705_abnormal_hypodermis_morpholog1.77889204
34MP0003186_abnormal_redox_activity1.76496563
35MP0001853_heart_inflammation1.76050402
36MP0003191_abnormal_cellular_cholesterol1.74001195
37MP0010329_abnormal_lipoprotein_level1.73082436
38MP0002138_abnormal_hepatobiliary_system1.72231409
39MP0006036_abnormal_mitochondrial_physio1.68213577
40MP0002398_abnormal_bone_marrow1.66700340
41MP0009115_abnormal_fat_cell1.62121601
42MP0002970_abnormal_white_adipose1.61582349
43MP0002796_impaired_skin_barrier1.59190079
44MP0003763_abnormal_thymus_physiology1.58175747
45MP0000751_myopathy1.57464077
46MP0008057_abnormal_DNA_replication1.54258590
47MP0005408_hypopigmentation1.52442660
48MP0005332_abnormal_amino_acid1.50901737
49MP0005375_adipose_tissue_phenotype1.46244765
50MP0002006_tumorigenesis1.45518180
51MP0003950_abnormal_plasma_membrane1.42314659
52MP0010234_abnormal_vibrissa_follicle1.40983307
53MP0002971_abnormal_brown_adipose1.40017301
54MP0010368_abnormal_lymphatic_system1.39692900
55MP0000343_altered_response_to1.39598051
56MP0000490_abnormal_crypts_of1.39551187
57MP0004036_abnormal_muscle_relaxation1.37331967
58MP0000689_abnormal_spleen_morphology1.35519935
59MP0000566_synostosis1.35021210
60MP0009785_altered_susceptibility_to1.34304661
61MP0003941_abnormal_skin_development1.34059267
62MP0000013_abnormal_adipose_tissue1.33204968
63MP0005023_abnormal_wound_healing1.32638790
64MP0005535_abnormal_body_temperature1.32333876
65MP0002722_abnormal_immune_system1.29844704
66MP0006138_congestive_heart_failure1.29362439
67MP0005025_abnormal_response_to1.28226508
68MP0000749_muscle_degeneration1.26427189
69MP0000609_abnormal_liver_physiology1.25793136
70MP0005334_abnormal_fat_pad1.25088233
71MP0004087_abnormal_muscle_fiber1.24502894
72MP0002429_abnormal_blood_cell1.23429424
73MP0004185_abnormal_adipocyte_glucose1.22899979
74MP0001915_intracranial_hemorrhage1.22081724
75MP0008775_abnormal_heart_ventricle1.21826131
76MP0005671_abnormal_response_to1.21291209
77MP0001764_abnormal_homeostasis1.20625192
78MP0000685_abnormal_immune_system1.20458762
79MP0005584_abnormal_enzyme/coenzyme_acti1.19228764
80MP0005085_abnormal_gallbladder_physiolo1.18494199
81MP0009384_cardiac_valve_regurgitation1.18367784
82MP0009780_abnormal_chondrocyte_physiolo1.18342441
83MP0005319_abnormal_enzyme/_coenzyme1.17945485
84MP0000716_abnormal_immune_system1.17120792
85MP0001958_emphysema1.17117621
86MP0010352_gastrointestinal_tract_polyps1.16637953
87MP0002060_abnormal_skin_morphology1.16151922
88MP0004858_abnormal_nervous_system1.13916492
89MP0003828_pulmonary_edema1.13415038
90MP0003453_abnormal_keratinocyte_physiol1.11772503
91MP0002420_abnormal_adaptive_immunity1.11219136
92MP0002419_abnormal_innate_immunity1.10673622
93MP0005409_darkened_coat_color1.09933365
94MP0002118_abnormal_lipid_homeostasis1.08806158
95MP0001819_abnormal_immune_cell1.08214157
96MP0000747_muscle_weakness1.07634417
97MP0005164_abnormal_response_to1.06630337
98MP0008007_abnormal_cellular_replicative1.06496519
99MP0003111_abnormal_nucleus_morphology1.06441118
100MP0000579_abnormal_nail_morphology1.06435088
101MP0001800_abnormal_humoral_immune1.06272424
102MP0002269_muscular_atrophy1.05747036
103MP0008469_abnormal_protein_level1.03999293
104MP0003279_aneurysm1.03509196
105MP0004233_abnormal_muscle_weight1.03108694
106MP0003221_abnormal_cardiomyocyte_apopto1.02188926
107MP0002019_abnormal_tumor_incidence1.02020221
108MP0002102_abnormal_ear_morphology1.01848564
109MP0002876_abnormal_thyroid_physiology1.01610885
110MP0009697_abnormal_copulation1.01259971
111MP0004145_abnormal_muscle_electrophysio1.00809653
112MP0002877_abnormal_melanocyte_morpholog1.00240613
113MP0002132_abnormal_respiratory_system0.99680110
114MP0004084_abnormal_cardiac_muscle0.98405600
115MP0000762_abnormal_tongue_morphology0.98222049
116MP0003959_abnormal_lean_body0.97166027
117MP0002452_abnormal_antigen_presenting0.96824171
118MP0000703_abnormal_thymus_morphology0.96355074
119MP0002723_abnormal_immune_serum0.95742610
120MP0003077_abnormal_cell_cycle0.95416196
121MP0010630_abnormal_cardiac_muscle0.95379478
122MP0001348_abnormal_lacrimal_gland0.94732451
123MP0005379_endocrine/exocrine_gland_phen0.93824596
124MP0004883_abnormal_blood_vessel0.93009126
125MP0010155_abnormal_intestine_physiology0.92655382
126MP0005647_abnormal_sex_gland0.92514858
127MP0001986_abnormal_taste_sensitivity0.92491363
128MP0004019_abnormal_vitamin_homeostasis0.92322087
129MP0001873_stomach_inflammation0.92304041
130MP0002095_abnormal_skin_pigmentation0.92218994
131MP0000003_abnormal_adipose_tissue0.91729572
132MP0003866_abnormal_defecation0.91723273
133MP0000467_abnormal_esophagus_morphology0.90920175
134MP0000759_abnormal_skeletal_muscle0.89941726
135MP0009763_increased_sensitivity_to0.89905787
136MP0005360_urolithiasis0.89119111
137MP0002108_abnormal_muscle_morphology0.88244104
138MP0000598_abnormal_liver_morphology0.86626677
139MP0009643_abnormal_urine_homeostasis0.85981329
140MP0000858_altered_metastatic_potential0.85759586
141MP0005000_abnormal_immune_tolerance0.85694552
142MP0002106_abnormal_muscle_physiology0.85204315
143MP0003646_muscle_fatigue0.82086714
144MP0003690_abnormal_glial_cell0.81832523
145MP0002405_respiratory_system_inflammati0.81449357
146MP0005501_abnormal_skin_physiology0.81365719
147MP0000750_abnormal_muscle_regeneration0.80920600
148MP0000733_abnormal_muscle_development0.80514032
149MP0005248_abnormal_Harderian_gland0.80323018
150MP0001845_abnormal_inflammatory_respons0.80145282
151MP0005369_muscle_phenotype0.79760674
152MP0004264_abnormal_extraembryonic_tissu0.78530825
153MP0005452_abnormal_adipose_tissue0.78277746
154MP0010678_abnormal_skin_adnexa0.78266165
155MP0005076_abnormal_cell_differentiation0.77907372
156MP0001661_extended_life_span0.77502154
157MP0002837_dystrophic_cardiac_calcinosis0.75664406
158MP0009379_abnormal_foot_pigmentation0.74878188
159MP0005330_cardiomyopathy0.74676959
160MP0003300_gastrointestinal_ulcer0.74662895
161MP0003693_abnormal_embryo_hatching0.74465118
162MP0005620_abnormal_muscle_contractility0.72406140
163MP0003868_abnormal_feces_composition0.71385148
164MP0009333_abnormal_splenocyte_physiolog0.71188043
165MP0000767_abnormal_smooth_muscle0.70249394
166MP0002972_abnormal_cardiac_muscle0.69983414
167MP0003091_abnormal_cell_migration0.69769341
168MP0005167_abnormal_blood-brain_barrier0.68272353
169MP0000383_abnormal_hair_follicle0.68093228
170MP0000249_abnormal_blood_vessel0.66036119
171MP0002128_abnormal_blood_circulation0.65671917
172MP0000537_abnormal_urethra_morphology0.65593425
173MP0001216_abnormal_epidermal_layer0.64154356
174MP0005187_abnormal_penis_morphology0.63252278
175MP0001851_eye_inflammation0.62987956

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.53992502
2Abnormality of monocarboxylic acid metabolism (HP:0010996)6.37428609
3Complement deficiency (HP:0004431)5.90568122
4Aplastic anemia (HP:0001915)5.30757563
5Prolonged bleeding time (HP:0003010)5.13403476
6Petechiae (HP:0000967)5.11887289
7Abnormal number of erythroid precursors (HP:0012131)5.11083130
8Abnormality of cells of the erythroid lineage (HP:0012130)4.83192775
9Prolonged partial thromboplastin time (HP:0003645)4.80976578
10Abnormality of complement system (HP:0005339)4.68066850
11Chronic otitis media (HP:0000389)4.64064932
12Hypobetalipoproteinemia (HP:0003563)4.52497299
13Abnormality of the heme biosynthetic pathway (HP:0010472)4.26290521
14Conjugated hyperbilirubinemia (HP:0002908)4.17911972
15Abnormality of aromatic amino acid family metabolism (HP:0004338)4.01016917
16Muscle fiber inclusion bodies (HP:0100299)3.94004680
17Joint hemorrhage (HP:0005261)3.91956253
18Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.89448972
19Nemaline bodies (HP:0003798)3.84909754
20Abnormality of the common coagulation pathway (HP:0010990)3.79076979
21Exercise-induced myalgia (HP:0003738)3.57364845
22Abnormal platelet function (HP:0011869)3.57070219
23Impaired platelet aggregation (HP:0003540)3.57070219
24Purpura (HP:0000979)3.52841482
25Hypolipoproteinemia (HP:0010981)3.47656300
26Abnormal platelet volume (HP:0011876)3.45320608
27Glomerulonephritis (HP:0000099)3.43954937
28Systemic lupus erythematosus (HP:0002725)3.34633548
29Hypertriglyceridemia (HP:0002155)3.28153240
30Increased mean platelet volume (HP:0011877)3.25577011
31Epistaxis (HP:0000421)3.23003690
32IgM deficiency (HP:0002850)3.18221602
33Hypoalphalipoproteinemia (HP:0003233)3.11282428
34Xanthomatosis (HP:0000991)3.10874723
35Thrombocytosis (HP:0001894)3.09076077
36Right ventricular cardiomyopathy (HP:0011663)3.05640568
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.02785389
38Increased muscle lipid content (HP:0009058)2.95143674
39Acute myeloid leukemia (HP:0004808)2.94161240
40Mitral stenosis (HP:0001718)2.93166892
41Hypercholesterolemia (HP:0003124)2.89914580
42Reticulocytopenia (HP:0001896)2.89888316
43Spontaneous abortion (HP:0005268)2.89101753
44Type 1 muscle fiber predominance (HP:0003803)2.87444517
45Pallor (HP:0000980)2.84824146
46Acanthocytosis (HP:0001927)2.79735334
47Abnormality of pyrimidine metabolism (HP:0004353)2.79525643
48Recurrent viral infections (HP:0004429)2.78838179
49Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.78826952
50Hypoplasia of the thymus (HP:0000778)2.75134393
51Muscle fiber atrophy (HP:0100295)2.75129717
52Abnormality of fatty-acid metabolism (HP:0004359)2.72644260
53Gingival bleeding (HP:0000225)2.70645028
54Abnormality of the nasal mucosa (HP:0000433)2.66175518
55Nasal polyposis (HP:0100582)2.65573568
56Arterial tortuosity (HP:0005116)2.64666939
57Nephritis (HP:0000123)2.62681347
58Reduced antithrombin III activity (HP:0001976)2.60701605
59Hyperlipoproteinemia (HP:0010980)2.59067863
60Vascular calcification (HP:0004934)2.58090194
61Type 2 muscle fiber atrophy (HP:0003554)2.55600825
62Fat malabsorption (HP:0002630)2.54040126
63Cardiovascular calcification (HP:0011915)2.52862252
64Aortic dissection (HP:0002647)2.49940738
65Neoplasm of head and neck (HP:0012288)2.41966941
66Esophageal neoplasm (HP:0100751)2.41966941
67Alopecia of scalp (HP:0002293)2.41627046
68Atrophic scars (HP:0001075)2.40720787
69Large hands (HP:0001176)2.39852777
70Vascular tortuosity (HP:0004948)2.39572634
71Bone cyst (HP:0012062)2.36866493
72Papilledema (HP:0001085)2.36499619
73Abnormality of dicarboxylic acid metabolism (HP:0010995)2.36213449
74Dicarboxylic aciduria (HP:0003215)2.36213449
75Hyporeflexia of lower limbs (HP:0002600)2.36144482
76Acute lymphatic leukemia (HP:0006721)2.34258853
77Recurrent bronchitis (HP:0002837)2.33792923
78Hepatic necrosis (HP:0002605)2.33210835
79Menorrhagia (HP:0000132)2.32012293
80Thyroid-stimulating hormone excess (HP:0002925)2.31559509
81Hemorrhage of the eye (HP:0011885)2.31449454
82Abnormality of the nasal septum (HP:0000419)2.28531202
83Poikilocytosis (HP:0004447)2.28529581
84Abnormality of the intrinsic pathway (HP:0010989)2.28462715
85Hyperammonemia (HP:0001987)2.28174348
86Hyperglycinuria (HP:0003108)2.27675768
87Protrusio acetabuli (HP:0003179)2.27415867
88Interstitial pulmonary disease (HP:0006530)2.26821177
89Oligomenorrhea (HP:0000876)2.25630195
90Abnormality of the fingertips (HP:0001211)2.23689532
91Type I transferrin isoform profile (HP:0003642)2.18950446
92Abnormality of carpal bone ossification (HP:0006257)2.18811429
93Abnormal spermatogenesis (HP:0008669)2.18339150
94Distal arthrogryposis (HP:0005684)2.17111780
95Panhypogammaglobulinemia (HP:0003139)2.14984677
96Pancytopenia (HP:0001876)2.14560877
97Abnormality of T cell physiology (HP:0011840)2.12957952
98Abnormality of lateral ventricle (HP:0030047)2.11744036
99Abnormality of glutamine family amino acid metabolism (HP:0010902)2.11258519
100Brushfield spots (HP:0001088)2.10665593
101Myelodysplasia (HP:0002863)2.10197092
102Increased connective tissue (HP:0009025)2.09783361
103Amaurosis fugax (HP:0100576)2.08939578
104Exercise-induced muscle cramps (HP:0003710)2.07222578
105Osteolytic defects of the phalanges of the hand (HP:0009771)2.06965356
106Osteolytic defects of the hand bones (HP:0009699)2.06965356
107Limb hypertonia (HP:0002509)2.06674532
108Recurrent fungal infections (HP:0002841)2.06430901
109Myocardial infarction (HP:0001658)2.06176495
110Aortic aneurysm (HP:0004942)2.06010522
111Abnormality of secondary sexual hair (HP:0009888)2.05586802
112Abnormality of the axillary hair (HP:0100134)2.05586802
113Abnormal delayed hypersensitivity skin test (HP:0002963)2.04693261
114Flat acetabular roof (HP:0003180)2.02777658
115Round ear (HP:0100830)2.00626429
116Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.00523265
117Abnormal protein N-linked glycosylation (HP:0012347)2.00523265
118Abnormal protein glycosylation (HP:0012346)2.00523265
119Abnormal glycosylation (HP:0012345)2.00523265
120Epidermoid cyst (HP:0200040)1.99145010
121Birth length less than 3rd percentile (HP:0003561)1.98891016
122Rhabdomyolysis (HP:0003201)1.98803080
123Osteomalacia (HP:0002749)1.98763123
124Macrocytic anemia (HP:0001972)1.98644852
125Increased intramyocellular lipid droplets (HP:0012240)1.98589933
126Elevated erythrocyte sedimentation rate (HP:0003565)1.98149243
127Hepatocellular necrosis (HP:0001404)1.97454386
128Abnormality of serine family amino acid metabolism (HP:0010894)1.96583377
129Abnormality of glycine metabolism (HP:0010895)1.96583377
130Reduced subcutaneous adipose tissue (HP:0003758)1.95316285
131Fragile skin (HP:0001030)1.94335682
132Aplasia involving bones of the extremities (HP:0009825)1.94065820
133Aplasia involving bones of the upper limbs (HP:0009823)1.94065820
134Aplasia of the phalanges of the hand (HP:0009802)1.94065820
135Abnormality of the prostate (HP:0008775)1.93942500
136Cellulitis (HP:0100658)1.93231914
137Fair hair (HP:0002286)1.92713821
138Hyperbilirubinemia (HP:0002904)1.92598904
139Increased serum ferritin (HP:0003281)1.91315377
140Advanced eruption of teeth (HP:0006288)1.90819711
141Easy fatigability (HP:0003388)1.89672126
142Cerebral aneurysm (HP:0004944)1.89509319
143Generalized aminoaciduria (HP:0002909)1.89275072
144Back pain (HP:0003418)1.88793321
145Hydroxyprolinuria (HP:0003080)1.88126903
146Abnormality of proline metabolism (HP:0010907)1.88126903
147Abnormal delivery (HP:0001787)1.88082845
148Steatorrhea (HP:0002570)1.87536463
149Abnormal ossification of hand bones (HP:0005921)1.86492698
150Ragged-red muscle fibers (HP:0003200)1.86027680
151Absent phalangeal crease (HP:0006109)1.85313693
152Hypoglycemic coma (HP:0001325)1.84858091
153Abnormality of reticulocytes (HP:0004312)1.83806755
154Hepatocellular carcinoma (HP:0001402)1.83771117
155Rickets (HP:0002748)1.83257138
156Ulnar deviation of the wrist (HP:0003049)1.81995903
157Facial diplegia (HP:0001349)1.81241025
158Premature rupture of membranes (HP:0001788)1.81084173
159Hyperacusis (HP:0010780)1.80633331
160Hypothermia (HP:0002045)1.80165795
161Nausea (HP:0002018)1.79993448
162Abnormality of the Achilles tendon (HP:0005109)1.79101858
163Plantar hyperkeratosis (HP:0007556)1.78972735
164Decreased activity of mitochondrial respiratory chain (HP:0008972)1.77990256
165Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.77990256
166EMG: myopathic abnormalities (HP:0003458)1.76873988
167High pitched voice (HP:0001620)1.76280700
168Popliteal pterygium (HP:0009756)1.76217865
169Abnormality of T cells (HP:0002843)1.76023913
170Ketosis (HP:0001946)1.75444404
171Muscle hypertrophy of the lower extremities (HP:0008968)1.74598320
172Elevated hepatic transaminases (HP:0002910)1.73816383
173Myopathic facies (HP:0002058)1.73792976
174Malnutrition (HP:0004395)1.72662782
175Muscle fiber splitting (HP:0003555)1.71456036
176Multiple enchondromatosis (HP:0005701)1.70957138
177Ulnar bowing (HP:0003031)1.70872109
178Pterygium (HP:0001059)1.70741344
179Hypotrichosis (HP:0001006)1.70332613
180Myositis (HP:0100614)1.70075979
181Skin nodule (HP:0200036)1.68802802
182Short middle phalanx of the 5th finger (HP:0004220)1.68290110
183Intrahepatic cholestasis (HP:0001406)1.68238656
184Azoospermia (HP:0000027)1.68230014
185Atrioventricular block (HP:0001678)1.68148029
186Gastrointestinal inflammation (HP:0004386)1.68127811
187Abnormality of nucleobase metabolism (HP:0010932)1.67938560
188Myoglobinuria (HP:0002913)1.67062575
189Palpitations (HP:0001962)1.66687476
190Insulin resistance (HP:0000855)1.66681451
191Palmoplantar hyperkeratosis (HP:0000972)1.64684768
192Neck muscle weakness (HP:0000467)1.63806038
193Abnormal hand bone ossification (HP:0010660)1.63735844
194Focal segmental glomerulosclerosis (HP:0000097)1.63446986

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R4.50570034
2OBSCN3.92045312
3KIT3.87486570
4EEF2K3.77133620
5STK162.88787338
6ERN12.82501399
7FGFR42.68942918
8MET2.65372741
9NME22.54711618
10FLT32.48129854
11EPHA22.47726299
12AKT32.43400228
13LATS12.40926771
14WEE12.38526853
15PIM22.34587018
16MAP4K12.21510041
17PKN22.19116257
18BCKDK2.17866283
19PHKG22.08712206
20PHKG12.08712206
21TNIK2.05714124
22MYLK2.05168457
23TAOK32.01397400
24MATK1.96997558
25MAPKAPK51.90858292
26RPS6KB21.90500782
27CDC71.90407867
28BTK1.87958216
29LMTK21.83858575
30LATS21.80892028
31ICK1.78236722
32BRSK21.68156990
33PIK3CA1.64743098
34TEC1.64432653
35TRIB31.64288000
36SCYL21.61115671
37MAPKAPK31.48818512
38FER1.43146800
39PDK21.41380227
40JAK31.41037124
41TIE11.38285823
42CSF1R1.38074051
43ERBB41.38010664
44TGFBR11.34787353
45MAP3K61.33784039
46NEK91.32660093
47CDK191.26779151
48MAPK71.24879570
49CAMK1D1.23245451
50MAP2K31.21288555
51MAP3K121.17775482
52PIK3CG1.15273580
53VRK11.14441654
54CDK41.14383029
55ATR1.11813122
56SYK1.11208420
57EPHA31.08197243
58MKNK11.07267192
59TGFBR21.07094903
60ZAP701.07080254
61PDGFRB1.06599373
62RAF11.06112572
63LRRK21.04375432
64STK38L1.01837478
65MAPK41.01367078
66PIM11.00496105
67CDK70.99250211
68DAPK10.98528248
69STK390.98100649
70STK240.96229758
71MAPK120.95336585
72TSSK60.94572902
73PTK20.94441407
74MTOR0.93861345
75TBK10.93761407
76SIK10.91283978
77FGFR10.90678261
78FES0.90548583
79GSK3A0.90533913
80JAK20.87198422
81CDK60.87152773
82PAK40.86844995
83MAP3K20.83473241
84TESK10.82450434
85STK40.82372448
86EPHB20.80868129
87KDR0.80737015
88TRPM70.80467331
89TYK20.77553208
90MAPK110.76958533
91DYRK30.76325384
92PRKG20.74712074
93CAMK10.74657653
94PBK0.74514774
95STK30.74352838
96IRAK40.73786455
97PAK20.73652898
98NLK0.73642639
99PRKAA20.73540389
100ILK0.72637832
101CDC42BPA0.71513277
102EPHB10.70904452
103DDR20.70422776
104MELK0.69398294
105NEK20.68889285
106PASK0.67897675
107PRKAA10.67497484
108LYN0.67326309
109GRK60.66320501
110CCNB10.64253362
111TAOK10.63708386
112TXK0.62109716
113MAP3K70.59720856
114ARAF0.59343635
115PDPK10.58199435
116TTN0.57316635
117SRPK10.57135794
118RET0.56968424
119TNK20.56313180
120MAP3K90.56144956
121SGK30.55383384
122CAMK2G0.54039333
123FGFR30.52738135
124MUSK0.52361224
125RPS6KA60.52042489
126RIPK10.51994266
127WNK10.51506372
128LCK0.51285009
129CAMK1G0.51187639
130RPS6KB10.50820570
131ALK0.50808129
132PRKD30.50720600
133PRKCE0.50667401
134AKT20.50436807
135CDK120.50380161
136MOS0.48940616
137IGF1R0.47349744
138IRAK30.46155371
139STK380.45907215
140BMX0.45398681
141PTK60.45381456
142NTRK10.44116769
143FRK0.43758993
144PDGFRA0.43408313
145PRPF4B0.42750799
146BLK0.42635393
147RPS6KL10.42554307
148RPS6KC10.42554307
149MAP3K110.42098852
150BRSK10.41705277
151PRKACG0.41561799
152RPS6KA20.41406272
153WNK40.41322997
154AURKB0.41174236
155SGK20.40355657
156MAPK30.40093999
157DMPK0.39828212
158PTK2B0.39793775
159IKBKE0.39777674
160IKBKB0.39370245
161MAP2K40.38289590
162JAK10.37938446
163MKNK20.37808597
164SGK2230.37530181
165SGK4940.37530181
166PDK30.36817673
167LIMK10.36236126
168MAP3K10.35650180
169MAP3K30.34567462

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.96106612
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.31575382
3Ribosome_Homo sapiens_hsa030103.24855807
4Mismatch repair_Homo sapiens_hsa034303.07122776
5Propanoate metabolism_Homo sapiens_hsa006402.91433558
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.86904444
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.58626088
8Arginine biosynthesis_Homo sapiens_hsa002202.57561467
9Retinol metabolism_Homo sapiens_hsa008302.53429699
10Homologous recombination_Homo sapiens_hsa034402.48109704
11Steroid hormone biosynthesis_Homo sapiens_hsa001402.34115831
12Base excision repair_Homo sapiens_hsa034102.27370469
13Fatty acid degradation_Homo sapiens_hsa000712.23934017
14PPAR signaling pathway_Homo sapiens_hsa033202.15550794
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.10535556
16Chemical carcinogenesis_Homo sapiens_hsa052042.09715594
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.88826079
18Fatty acid metabolism_Homo sapiens_hsa012121.85121272
19Pentose phosphate pathway_Homo sapiens_hsa000301.83068188
20Bile secretion_Homo sapiens_hsa049761.80740732
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.78788004
22Nucleotide excision repair_Homo sapiens_hsa034201.78264041
23Fatty acid biosynthesis_Homo sapiens_hsa000611.64926416
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.61740514
25Carbon metabolism_Homo sapiens_hsa012001.61214170
26Non-homologous end-joining_Homo sapiens_hsa034501.58463398
27Pyrimidine metabolism_Homo sapiens_hsa002401.57370366
28One carbon pool by folate_Homo sapiens_hsa006701.54207616
29Arginine and proline metabolism_Homo sapiens_hsa003301.52839127
30Caffeine metabolism_Homo sapiens_hsa002321.51654235
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.45874407
32beta-Alanine metabolism_Homo sapiens_hsa004101.45516354
33Spliceosome_Homo sapiens_hsa030401.40311528
34Peroxisome_Homo sapiens_hsa041461.39209934
35Cell cycle_Homo sapiens_hsa041101.37715998
36Vitamin B6 metabolism_Homo sapiens_hsa007501.37037093
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.35542637
38Hematopoietic cell lineage_Homo sapiens_hsa046401.33417344
39Pyruvate metabolism_Homo sapiens_hsa006201.31514393
40Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.29971816
41Platelet activation_Homo sapiens_hsa046111.25360083
42ABC transporters_Homo sapiens_hsa020101.21733087
43Tryptophan metabolism_Homo sapiens_hsa003801.19422022
44Fat digestion and absorption_Homo sapiens_hsa049751.19303634
45Acute myeloid leukemia_Homo sapiens_hsa052211.18046480
46Butanoate metabolism_Homo sapiens_hsa006501.17317074
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16558497
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.16131463
49N-Glycan biosynthesis_Homo sapiens_hsa005101.15140387
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13499280
51Vitamin digestion and absorption_Homo sapiens_hsa049771.11116979
52Adipocytokine signaling pathway_Homo sapiens_hsa049201.07987793
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07899965
54ECM-receptor interaction_Homo sapiens_hsa045121.07502596
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06306209
56Primary immunodeficiency_Homo sapiens_hsa053401.05662822
57Biosynthesis of amino acids_Homo sapiens_hsa012301.04131402
58Fructose and mannose metabolism_Homo sapiens_hsa000511.03066882
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02930889
60Herpes simplex infection_Homo sapiens_hsa051681.02761745
61Thyroid cancer_Homo sapiens_hsa052161.02171394
62Drug metabolism - other enzymes_Homo sapiens_hsa009831.00713186
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.98019296
64Prion diseases_Homo sapiens_hsa050200.97758053
65Folate biosynthesis_Homo sapiens_hsa007900.96358750
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93036437
67Linoleic acid metabolism_Homo sapiens_hsa005910.92731322
68Measles_Homo sapiens_hsa051620.90761492
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.90504643
70Arachidonic acid metabolism_Homo sapiens_hsa005900.88708788
71Antigen processing and presentation_Homo sapiens_hsa046120.84358862
72Glycerolipid metabolism_Homo sapiens_hsa005610.83831879
73RNA degradation_Homo sapiens_hsa030180.83405352
74Leishmaniasis_Homo sapiens_hsa051400.81948159
75Fanconi anemia pathway_Homo sapiens_hsa034600.80588026
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78927835
77B cell receptor signaling pathway_Homo sapiens_hsa046620.78393042
78Purine metabolism_Homo sapiens_hsa002300.78064965
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75355291
80Fatty acid elongation_Homo sapiens_hsa000620.74222285
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73604650
82Chronic myeloid leukemia_Homo sapiens_hsa052200.71682286
83Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.71271188
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70777670
85Renin-angiotensin system_Homo sapiens_hsa046140.68541482
86Small cell lung cancer_Homo sapiens_hsa052220.67738406
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67617354
88Steroid biosynthesis_Homo sapiens_hsa001000.66853745
89Circadian rhythm_Homo sapiens_hsa047100.66453821
90AMPK signaling pathway_Homo sapiens_hsa041520.66107779
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64920129
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64731250
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64035188
94Selenocompound metabolism_Homo sapiens_hsa004500.63879816
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.63005171
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62977259
97Glucagon signaling pathway_Homo sapiens_hsa049220.62928778
98Legionellosis_Homo sapiens_hsa051340.61630285
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.61235867
100Phenylalanine metabolism_Homo sapiens_hsa003600.58960590
101Sulfur metabolism_Homo sapiens_hsa009200.58857042
102Hepatitis B_Homo sapiens_hsa051610.58718318
103Amoebiasis_Homo sapiens_hsa051460.58479657
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58246790
105RNA transport_Homo sapiens_hsa030130.58145434
106Adherens junction_Homo sapiens_hsa045200.57350604
107Insulin resistance_Homo sapiens_hsa049310.57003148
108Focal adhesion_Homo sapiens_hsa045100.56223106
109Galactose metabolism_Homo sapiens_hsa000520.56169090
110Non-small cell lung cancer_Homo sapiens_hsa052230.56097903
111Mineral absorption_Homo sapiens_hsa049780.55706734
112Lysine degradation_Homo sapiens_hsa003100.54497402
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54204730
114Maturity onset diabetes of the young_Homo sapiens_hsa049500.52645754
115Protein digestion and absorption_Homo sapiens_hsa049740.50466128
116Dilated cardiomyopathy_Homo sapiens_hsa054140.47997277
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47411993
118Starch and sucrose metabolism_Homo sapiens_hsa005000.46076284
119Staphylococcus aureus infection_Homo sapiens_hsa051500.45227646
120RNA polymerase_Homo sapiens_hsa030200.44810754
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44776223
122Pertussis_Homo sapiens_hsa051330.44219215
123p53 signaling pathway_Homo sapiens_hsa041150.42156280
124Toxoplasmosis_Homo sapiens_hsa051450.42059263
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42035489
126NF-kappa B signaling pathway_Homo sapiens_hsa040640.41004149
127Glutathione metabolism_Homo sapiens_hsa004800.40318979
128Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40145112
129Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40074297
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.39824157
131Ovarian steroidogenesis_Homo sapiens_hsa049130.38873655
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.37640258
133Histidine metabolism_Homo sapiens_hsa003400.36660589
134Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36504914
135Complement and coagulation cascades_Homo sapiens_hsa046100.36420960
136Sulfur relay system_Homo sapiens_hsa041220.36237492
137Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36003665
138Metabolic pathways_Homo sapiens_hsa011000.34690449
139Tight junction_Homo sapiens_hsa045300.34127440
140Insulin signaling pathway_Homo sapiens_hsa049100.33529390
141Viral carcinogenesis_Homo sapiens_hsa052030.33252667
142Other glycan degradation_Homo sapiens_hsa005110.32740610
143Tyrosine metabolism_Homo sapiens_hsa003500.31361830
144Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.27698529
145Proteoglycans in cancer_Homo sapiens_hsa052050.23072525
146AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.20471886
147Glycerophospholipid metabolism_Homo sapiens_hsa005640.17839612
148Sphingolipid metabolism_Homo sapiens_hsa006000.16810526
149Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15374504
150Vascular smooth muscle contraction_Homo sapiens_hsa042700.13082483
151Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.11100043

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