ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	surfactant homeostasis (GO:0043129)	6.78637468
2	very-low-density lipoprotein particle assembly (GO:0034379)	6.50412703
3	plasma lipoprotein particle assembly (GO:0034377)	6.16871999
4	negative regulation of fibrinolysis (GO:0051918)	6.12565500
5	intestinal cholesterol absorption (GO:0030299)	6.07114120
6	peptidyl-glutamic acid carboxylation (GO:0017187)	6.05063012
7	protein carboxylation (GO:0018214)	6.05063012
8	lung epithelium development (GO:0060428)	5.62648920
9	protein-lipid complex assembly (GO:0065005)	5.54691552
10	regulation of apoptotic cell clearance (GO:2000425)	5.39873281
11	regulation of cholesterol homeostasis (GO:2000188)	5.35642691
12	chemical homeostasis within a tissue (GO:0048875)	5.30883238
13	low-density lipoprotein particle remodeling (GO:0034374)	5.26904081
14	cholesterol efflux (GO:0033344)	5.16044481
15	proline metabolic process (GO:0006560)	5.03188888
16	regulation of cholesterol esterification (GO:0010872)	4.93880612
17	regulation of fibrinolysis (GO:0051917)	4.93483312
18	regulation of cholesterol biosynthetic process (GO:0045540)	4.77563651
19	plasma lipoprotein particle remodeling (GO:0034369)	4.72850286
20	protein-lipid complex remodeling (GO:0034368)	4.72850286
21	macromolecular complex remodeling (GO:0034367)	4.72850286
22	regulation of complement activation (GO:0030449)	4.70667058
23	regulation of protein activation cascade (GO:2000257)	4.67193123
24	positive regulation of synapse maturation (GO:0090129)	4.66744707
25	plasma lipoprotein particle organization (GO:0071827)	4.63990885
26	protein-lipid complex subunit organization (GO:0071825)	4.39339800
27	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	4.26377051
28	proline biosynthetic process (GO:0006561)	4.24113577
29	regulation of bile acid biosynthetic process (GO:0070857)	4.23819604
30	regulation of plasminogen activation (GO:0010755)	4.18814372
31	high-density lipoprotein particle remodeling (GO:0034375)	4.16965683
32	plasma lipoprotein particle clearance (GO:0034381)	4.12040623
33	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	4.08633238
34	phosphate ion homeostasis (GO:0055062)	4.00351461
35	trivalent inorganic anion homeostasis (GO:0072506)	4.00351461
36	reverse cholesterol transport (GO:0043691)	3.98955792
37	cellular sodium ion homeostasis (GO:0006883)	3.97735264
38	blood coagulation, intrinsic pathway (GO:0007597)	3.93617837
39	neurotransmitter-gated ion channel clustering (GO:0072578)	3.80295953
40	negative regulation of protein activation cascade (GO:2000258)	3.75616065
41	glutamate metabolic process (GO:0006536)	3.67541352
42	intestinal absorption (GO:0050892)	3.67479053
43	negative regulation of cholesterol transport (GO:0032375)	3.66939988
44	negative regulation of sterol transport (GO:0032372)	3.66939988
45	regulation of synapse maturation (GO:0090128)	3.58569012
46	positive regulation of fatty acid biosynthetic process (GO:0045723)	3.53967337
47	low-density lipoprotein particle clearance (GO:0034383)	3.51697839
48	positive regulation of steroid metabolic process (GO:0045940)	3.50914607
49	cellular anion homeostasis (GO:0030002)	3.46950665
50	positive regulation of hormone metabolic process (GO:0032352)	3.43648879
51	cellular zinc ion homeostasis (GO:0006882)	3.41896782
52	positive regulation of dendritic spine morphogenesis (GO:0061003)	3.38659852
53	negative regulation of complement activation (GO:0045916)	3.36836881
54	positive regulation of extracellular matrix organization (GO:1903055)	3.34803718
55	embryonic retina morphogenesis in camera-type eye (GO:0060059)	3.33725102
56	cholesterol homeostasis (GO:0042632)	3.31531970
57	regulation of cholesterol metabolic process (GO:0090181)	3.31365037
58	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.31227322
59	L-phenylalanine metabolic process (GO:0006558)	3.31227322
60	synaptic vesicle docking involved in exocytosis (GO:0016081)	3.29888890
61	sterol homeostasis (GO:0055092)	3.28343539
62	diacylglycerol metabolic process (GO:0046339)	3.27585078
63	cell-cell junction maintenance (GO:0045217)	3.26213539
64	sterol transport (GO:0015918)	3.24984245
65	cholesterol transport (GO:0030301)	3.24984245
66	phosphate ion transmembrane transport (GO:0035435)	3.24602357
67	layer formation in cerebral cortex (GO:0021819)	3.21621133
68	central nervous system myelination (GO:0022010)	3.20708177
69	axon ensheathment in central nervous system (GO:0032291)	3.20708177
70	lipoprotein metabolic process (GO:0042157)	3.19454028
71	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	3.18735453
72	dicarboxylic acid biosynthetic process (GO:0043650)	3.18388565
73	renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)	3.17838534
74	regulation of extracellular matrix organization (GO:1903053)	3.17361379
75	negative regulation of sodium ion transport (GO:0010766)	3.14684247
76	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.13692765
77	L-phenylalanine catabolic process (GO:0006559)	3.13692765
78	pinocytosis (GO:0006907)	3.10686156
79	regulation of extracellular matrix disassembly (GO:0010715)	3.10642607
80	protein retention in ER lumen (GO:0006621)	3.10548050
81	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	3.09292821
82	sodium ion export (GO:0071436)	3.08368588
83	receptor catabolic process (GO:0032801)	3.03440210
84	nephron tubule morphogenesis (GO:0072078)	3.01699103
85	nephron epithelium morphogenesis (GO:0072088)	3.01699103
86	glutamine family amino acid biosynthetic process (GO:0009084)	3.00471154
87	phospholipid efflux (GO:0033700)	3.00010559
88	positive regulation of phagocytosis (GO:0050766)	2.99414422
89	positive regulation of hormone biosynthetic process (GO:0046886)	2.96000451
90	glutamate secretion (GO:0014047)	2.95930382
91	sodium ion homeostasis (GO:0055078)	2.93108822
92	modified amino acid transport (GO:0072337)	2.87905053
93	drinking behavior (GO:0042756)	2.87065772
94	response to vitamin A (GO:0033189)	2.81972837
95	positive regulation of lipoprotein lipase activity (GO:0051006)	2.79871475
96	positive regulation of triglyceride lipase activity (GO:0061365)	2.79871475
97	regulation of cell-cell adhesion mediated by cadherin (GO:2000047)	2.77539404
98	oligosaccharide catabolic process (GO:0009313)	2.75996842
99	cerebellar granule cell differentiation (GO:0021707)	2.74162281
100	basement membrane organization (GO:0071711)	2.72723221

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	5.45707458
2	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	3.56329841
3	ZNF263_19887448_ChIP-Seq_K562_Human	3.24771457
4	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	3.16712296
5	RXR_22158963_ChIP-Seq_LIVER_Mouse	3.00658693
6	FOXA2_19822575_ChIP-Seq_HepG2_Human	2.74709690
7	LXR_22292898_ChIP-Seq_THP-1_Human	2.72448438
8	PPARA_22158963_ChIP-Seq_LIVER_Mouse	2.60876758
9	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.53649148
10	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.46687490
11	CLOCK_20551151_ChIP-Seq_293T_Human	2.25472872
12	ERG_21242973_ChIP-ChIP_JURKAT_Human	2.23257596
13	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.21792305
14	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.21617765
15	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.20895269
16	KDM2B_26808549_Chip-Seq_K562_Human	2.04866499
17	ZFP281_18757296_ChIP-ChIP_E14_Mouse	2.04254607
18	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.98822371
19	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.98481391
20	RACK7_27058665_Chip-Seq_MCF-7_Human	1.96458048
21	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.94083222
22	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.91392393
23	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.88773883
24	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.85370768
25	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.82015425
26	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.77645068
27	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.77337419
28	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.71878875
29	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.70858933
30	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.67780905
31	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.63246507
32	SMC4_20622854_ChIP-Seq_HELA_Human	1.62459998
33	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.60550982
34	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.59956532
35	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.58754182
36	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.57906171
37	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.57243622
38	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.53650519
39	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.52909426
40	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.51967685
41	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.45373469
42	P68_20966046_ChIP-Seq_HELA_Human	1.45163770
43	CREB1_26743006_Chip-Seq_LNCaP_Human	1.44060696
44	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.40538346
45	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.39900193
46	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	1.39744190
47	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.38968908
48	TCF7_22412390_ChIP-Seq_EML_Mouse	1.38499342
49	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.33199377
50	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.32257907
51	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.32095949
52	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.30420807
53	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.30391806
54	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.29534671
55	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.27322791
56	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.25069039
57	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.24410205
58	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.22747699
59	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.21303066
60	MYC_22102868_ChIP-Seq_BL_Human	1.19928495
61	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.16304179
62	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.15960149
63	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.14594272
64	CTCF_27219007_Chip-Seq_Bcells_Human	1.14526067
65	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.14059879
66	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.14028323
67	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.13682746
68	DROSHA_22980978_ChIP-Seq_HELA_Human	1.13180004
69	KDM2B_26808549_Chip-Seq_DND41_Human	1.13064529
70	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.12449849
71	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.11915735
72	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.10436691
73	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.10394831
74	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.08578166
75	AR_21909140_ChIP-Seq_LNCAP_Human	1.07334105
76	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.07019812
77	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	1.06926835
78	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.06029658
79	TP53_22127205_ChIP-Seq_IMR90_Human	1.05722015
80	POU5F1_16518401_ChIP-PET_MESCs_Mouse	1.05556619
81	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.05006858
82	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.04952305
83	ATF3_27146783_Chip-Seq_COLON_Human	1.04823692
84	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.02496340
85	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.01477982
86	TET1_21490601_ChIP-Seq_MESCs_Mouse	1.01042580
87	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.00433982
88	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.99818697
89	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	0.99806767
90	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.99175347
91	TRIM28_21343339_ChIP-Seq_HEK293_Human	0.98634798
92	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.97178408
93	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.95369881
94	KAP1_27257070_Chip-Seq_ESCs_Mouse	0.93944336
95	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	0.93452469
96	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.92045132
97	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	0.91804740
98	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.91245450
99	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.90965629
100	GATA6_25053715_ChIP-Seq_YYC3_Human	0.90427963

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	5.72778012
2	MP0003122_maternal_imprinting	5.29473536
3	MP0000566_synostosis	4.48434816
4	MP0003123_paternal_imprinting	3.86463899
5	MP0004782_abnormal_surfactant_physiolog	3.33517323
6	MP0003172_abnormal_lysosome_physiology	3.21292743
7	MP0009780_abnormal_chondrocyte_physiolo	2.99149332
8	MP0005365_abnormal_bile_salt	2.95124904
9	MP0002089_abnormal_postnatal_growth/wei	2.90989036
10	MP0010329_abnormal_lipoprotein_level	2.76831917
11	MP0005058_abnormal_lysosome_morphology	2.59386777
12	MP0001666_abnormal_nutrient_absorption	2.49851746
13	MP0002139_abnormal_hepatobiliary_system	2.44934639
14	MP0004270_analgesia	2.30498379
15	MP0008875_abnormal_xenobiotic_pharmacok	2.13386664
16	MP0003195_calcinosis	2.07949324
17	MP0005451_abnormal_body_composition	2.01558847
18	MP0003879_abnormal_hair_cell	1.98994528
19	MP0005409_darkened_coat_color	1.89605467
20	MP0004859_abnormal_synaptic_plasticity	1.82276008
21	MP0003329_amyloid_beta_deposits	1.81935604
22	MP0001958_emphysema	1.79602425
23	MP0005167_abnormal_blood-brain_barrier	1.66351473
24	MP0008260_abnormal_autophagy	1.65743164
25	MP0000678_abnormal_parathyroid_gland	1.65165944
26	MP0005085_abnormal_gallbladder_physiolo	1.63374262
27	MP0005076_abnormal_cell_differentiation	1.59352254
28	MP0001915_intracranial_hemorrhage	1.48775852
29	MP0009840_abnormal_foam_cell	1.47386701
30	MP0002118_abnormal_lipid_homeostasis	1.47233892
31	MP0003115_abnormal_respiratory_system	1.45774804
32	MP0008569_lethality_at_weaning	1.40698133
33	MP0003121_genomic_imprinting	1.36834799
34	MP0000639_abnormal_adrenal_gland	1.36568195
35	MP0000920_abnormal_myelination	1.34817353
36	MP0003566_abnormal_cell_adhesion	1.32199562
37	MP0009046_muscle_twitch	1.30800911
38	MP0002249_abnormal_larynx_morphology	1.29806104
39	MP0002064_seizures	1.29017509
40	MP0005423_abnormal_somatic_nervous	1.22963118
41	MP0001348_abnormal_lacrimal_gland	1.18371088
42	MP0003942_abnormal_urinary_system	1.18290327
43	MP0001177_atelectasis	1.14383013
44	MP0003690_abnormal_glial_cell	1.13135311
45	MP0005332_abnormal_amino_acid	1.11965142
46	MP0003252_abnormal_bile_duct	1.10699342
47	MP0000604_amyloidosis	1.08551712
48	MP0003705_abnormal_hypodermis_morpholog	1.07272005
49	MP0003635_abnormal_synaptic_transmissio	1.06999785
50	MP0004264_abnormal_extraembryonic_tissu	1.05824093
51	MP0000609_abnormal_liver_physiology	1.05347626
52	MP0003878_abnormal_ear_physiology	0.99077186
53	MP0005377_hearing/vestibular/ear_phenot	0.99077186
54	MP0005083_abnormal_biliary_tract	0.98821237
55	MP0004272_abnormal_basement_membrane	0.97657349
56	MP0003632_abnormal_nervous_system	0.97108003
57	MP0008995_early_reproductive_senescence	0.95843643
58	MP0005257_abnormal_intraocular_pressure	0.94117526
59	MP0000681_abnormal_thyroid_gland	0.90982325
60	MP0005410_abnormal_fertilization	0.90586786
61	MP0003880_abnormal_central_pattern	0.89095305
62	MP0005408_hypopigmentation	0.87687099
63	MP0004742_abnormal_vestibular_system	0.82763811
64	MP0001849_ear_inflammation	0.82391248
65	MP0002063_abnormal_learning/memory/cond	0.81894032
66	MP0004858_abnormal_nervous_system	0.81559406
67	MP0003631_nervous_system_phenotype	0.81437143
68	MP0001486_abnormal_startle_reflex	0.80371873
69	MP0001270_distended_abdomen	0.77544915
70	MP0001661_extended_life_span	0.74742477
71	MP0003634_abnormal_glial_cell	0.74484366
72	MP0002557_abnormal_social/conspecific_i	0.73886048
73	MP0003315_abnormal_perineum_morphology	0.73726192
74	MP0000534_abnormal_ureter_morphology	0.73647012
75	MP0003633_abnormal_nervous_system	0.72772857
76	MP0001440_abnormal_grooming_behavior	0.72293353
77	MP0010368_abnormal_lymphatic_system	0.70430903
78	MP0001346_abnormal_lacrimal_gland	0.67728622
79	MP0009672_abnormal_birth_weight	0.67011745
80	MP0005388_respiratory_system_phenotype	0.66093842
81	MP0002133_abnormal_respiratory_system	0.66093842
82	MP0003950_abnormal_plasma_membrane	0.65862261
83	MP0003191_abnormal_cellular_cholesterol	0.64230658
84	MP0003868_abnormal_feces_composition	0.63728132
85	MP0002229_neurodegeneration	0.62836219
86	MP0002909_abnormal_adrenal_gland	0.61905166
87	MP0003075_altered_response_to	0.61669231
88	MP0002572_abnormal_emotion/affect_behav	0.60841594
89	MP0000003_abnormal_adipose_tissue	0.60450784
90	MP0004185_abnormal_adipocyte_glucose	0.60288525
91	MP0002184_abnormal_innervation	0.59833970
92	MP0000598_abnormal_liver_morphology	0.59362868
93	MP0000955_abnormal_spinal_cord	0.58798346
94	MP0005646_abnormal_pituitary_gland	0.57844178
95	MP0002272_abnormal_nervous_system	0.55999663
96	MP0003656_abnormal_erythrocyte_physiolo	0.54899703
97	MP0010234_abnormal_vibrissa_follicle	0.54829610
98	MP0002132_abnormal_respiratory_system	0.54459319
99	MP0001730_embryonic_growth_arrest	0.54209525
100	MP0009384_cardiac_valve_regurgitation	0.54080011

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Deep venous thrombosis (HP:0002625)	9.07257443
2	Joint hemorrhage (HP:0005261)	5.74812837
3	Prolonged partial thromboplastin time (HP:0003645)	4.89201884
4	Hemorrhage of the eye (HP:0011885)	4.21972810
5	Complement deficiency (HP:0004431)	4.06422853
6	Hypercholesterolemia (HP:0003124)	4.05931562
7	Xanthomatosis (HP:0000991)	4.00404287
8	Glomerulonephritis (HP:0000099)	3.71925330
9	Hypobetalipoproteinemia (HP:0003563)	3.58069237
10	Interstitial pulmonary disease (HP:0006530)	3.48976581
11	Small epiphyses (HP:0010585)	3.41081220
12	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.35106597
13	Menorrhagia (HP:0000132)	3.23308528
14	Abnormality of complement system (HP:0005339)	3.17728302
15	Abnormality of the common coagulation pathway (HP:0010990)	3.17170230
16	Systemic lupus erythematosus (HP:0002725)	3.14624862
17	Cerebral aneurysm (HP:0004944)	3.11780456
18	Asymmetry of the thorax (HP:0001555)	3.07175715
19	Broad alveolar ridges (HP:0000187)	2.88330969
20	Bronchomalacia (HP:0002780)	2.79658958
21	Neurofibrillary tangles (HP:0002185)	2.79186453
22	Purpura (HP:0000979)	2.76743856
23	Abnormality of carpal bone ossification (HP:0006257)	2.64612207
24	Epiphyseal dysplasia (HP:0002656)	2.59037963
25	Alacrima (HP:0000522)	2.57478234
26	Abnormality of the lumbar spine (HP:0100712)	2.56293862
27	Vaginal fistula (HP:0004320)	2.53994260
28	Hypolipoproteinemia (HP:0010981)	2.53873365
29	Vascular calcification (HP:0004934)	2.44335338
30	Broad palm (HP:0001169)	2.43166995
31	Mitral stenosis (HP:0001718)	2.31442769
32	Gout (HP:0001997)	2.29568755
33	Impaired pain sensation (HP:0007328)	2.29105929
34	Abnormality of pain sensation (HP:0010832)	2.29105929
35	Protrusio acetabuli (HP:0003179)	2.26752665
36	Acanthocytosis (HP:0001927)	2.26629595
37	Supranuclear gaze palsy (HP:0000605)	2.26474464
38	Cerebral inclusion bodies (HP:0100314)	2.25503531
39	Renal duplication (HP:0000075)	2.24522225
40	Aplasia involving bones of the extremities (HP:0009825)	2.21205079
41	Aplasia involving bones of the upper limbs (HP:0009823)	2.21205079
42	Aplasia of the phalanges of the hand (HP:0009802)	2.21205079
43	Flat acetabular roof (HP:0003180)	2.21199334
44	Myocardial infarction (HP:0001658)	2.21159085
45	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.20149653
46	Skin nodule (HP:0200036)	2.16375610
47	Irregular epiphyses (HP:0010582)	2.14763217
48	Bifid scrotum (HP:0000048)	2.12001476
49	Cardiovascular calcification (HP:0011915)	2.07174720
50	Epidermoid cyst (HP:0200040)	2.07070145
51	Scanning speech (HP:0002168)	2.06971241
52	Abnormal ossification of hand bones (HP:0005921)	2.05668926
53	Limited elbow extension (HP:0001377)	2.05464763
54	Hypoalphalipoproteinemia (HP:0003233)	2.05060273
55	Growth hormone excess (HP:0000845)	2.04554824
56	Epileptic encephalopathy (HP:0200134)	2.04266196
57	Pancreatic islet-cell hyperplasia (HP:0004510)	2.03048409
58	Neonatal death (HP:0003811)	2.02819465
59	Spontaneous abortion (HP:0005268)	2.01158913
60	Hepatoblastoma (HP:0002884)	1.98711508
61	Abnormal tarsal ossification (HP:0008369)	1.91416606
62	Abnormality of the Achilles tendon (HP:0005109)	1.90554985
63	Ulnar bowing (HP:0003031)	1.89567204
64	Wide nose (HP:0000445)	1.88525916
65	Insomnia (HP:0100785)	1.88069008
66	Abnormal hand bone ossification (HP:0010660)	1.86741765
67	Annular pancreas (HP:0001734)	1.85701417
68	Absent epiphyses (HP:0010577)	1.85302493
69	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.85302493
70	Arnold-Chiari malformation (HP:0002308)	1.82860806
71	Abnormality of the lacrimal duct (HP:0011481)	1.82343794
72	Nasolacrimal duct obstruction (HP:0000579)	1.81425508
73	Abnormal gallbladder physiology (HP:0012438)	1.81174838
74	Cholecystitis (HP:0001082)	1.81174838
75	Status epilepticus (HP:0002133)	1.81053859
76	Flared iliac wings (HP:0002869)	1.78836281
77	Urinary glycosaminoglycan excretion (HP:0003541)	1.76427394
78	Mucopolysacchariduria (HP:0008155)	1.76427394
79	Facial shape deformation (HP:0011334)	1.75608648
80	Potter facies (HP:0002009)	1.75608648
81	Hypophosphatemic rickets (HP:0004912)	1.74948495
82	Choanal stenosis (HP:0000452)	1.73922845
83	Menstrual irregularities (HP:0000858)	1.73351021
84	Decreased lacrimation (HP:0000633)	1.72918270
85	Akinesia (HP:0002304)	1.71841533
86	Biconcave vertebral bodies (HP:0004586)	1.71321743
87	Hepatocellular carcinoma (HP:0001402)	1.70152299
88	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.69289683
89	Abnormality of the nasal septum (HP:0000419)	1.69081413
90	Heterotopia (HP:0002282)	1.68665910
91	Atonic seizures (HP:0010819)	1.67812024
92	Hyperacusis (HP:0010780)	1.67603637
93	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.66625460
94	Supernumerary ribs (HP:0005815)	1.66120068
95	Gonadal dysgenesis (HP:0000133)	1.64298265
96	Hypotension (HP:0002615)	1.61609673
97	Widely patent fontanelles and sutures (HP:0004492)	1.61539089
98	Renovascular hypertension (HP:0100817)	1.61475880
99	Abnormality of the vitreous humor (HP:0004327)	1.60536257
100	Action tremor (HP:0002345)	1.60111615

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FGFR4	6.24368927
2	ICK	3.65441930
3	FGFR3	3.46385919
4	RIPK1	3.39684947
5	TRIB3	3.25612481
6	WNK4	2.59908385
7	TYRO3	2.51723541
8	EEF2K	2.47478009
9	CDK12	2.32219558
10	EPHA2	2.27819223
11	NTRK3	2.15953925
12	ERN1	1.91630007
13	LATS2	1.90374123
14	WNK1	1.87710173
15	SIK1	1.87654676
16	PDGFRA	1.87287355
17	FGFR2	1.84016434
18	SMG1	1.83691758
19	MST1R	1.76864212
20	MAP3K9	1.71332645
21	EPHA4	1.63720254
22	PKN2	1.55657279
23	FGFR1	1.54874955
24	DAPK2	1.50432652
25	PDPK1	1.43184534
26	NTRK2	1.38836711
27	DYRK1B	1.38442406
28	SIK2	1.38297319
29	MARK2	1.22393859
30	RET	1.13050826
31	KSR2	1.12903300
32	UHMK1	1.11923245
33	CAMKK1	1.11761674
34	DDR2	1.11197241
35	PRKD3	1.10065580
36	SGK223	1.05299258
37	SGK494	1.05299258
38	PDK1	0.94752964
39	PRPF4B	0.94302662
40	NTRK1	0.91621802
41	MAPK11	0.90455566
42	LATS1	0.89863623
43	BRSK1	0.86998084
44	CDC42BPA	0.86871573
45	MAP3K2	0.82496742
46	IRAK3	0.81731798
47	STK38	0.78865283
48	SGK3	0.78545863
49	PAK6	0.77884174
50	MET	0.77706162
51	AKT3	0.74793206
52	MAP3K1	0.74428754
53	MTOR	0.69355128
54	MAPKAPK3	0.68518852
55	ALK	0.68377676
56	MAP3K13	0.67301817
57	MINK1	0.66900365
58	LMTK2	0.65385076
59	ERBB2	0.64730427
60	PTK2	0.63896567
61	DAPK1	0.62819658
62	RPS6KB1	0.60201733
63	SGK1	0.58888824
64	MAP3K7	0.57726796
65	PTK6	0.57119456
66	CDK15	0.55919837
67	MAP2K6	0.53843423
68	NEK6	0.53093242
69	MAP3K11	0.52828928
70	PRKAA2	0.49547461
71	SGK2	0.49386199
72	ARAF	0.49333326
73	CDK18	0.49110630
74	CDK7	0.48460863
75	CAMK1D	0.48448884
76	CDK11A	0.48366514
77	PIK3CA	0.46196269
78	NME1	0.46071411
79	CAMK4	0.45963312
80	MAPK10	0.45655796
81	CDK5	0.45109405
82	FGR	0.43817540
83	PAK4	0.43066060
84	BMX	0.40059323
85	MAP2K3	0.39747741
86	CSNK1E	0.38350821
87	PRKAA1	0.37875756
88	CDK14	0.37761091
89	RPS6KA2	0.34933400
90	SRC	0.33612557
91	MAPK12	0.32446588
92	RPS6KA3	0.31780472
93	PDGFRB	0.29667379
94	HIPK2	0.28374874
95	MAPK8	0.26893104
96	RPS6KB2	0.25995594
97	MARK1	0.25778277
98	TGFBR2	0.25306302
99	CDK6	0.24498298
100	PRKG2	0.24371778

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Complement and coagulation cascades_Homo sapiens_hsa04610	4.29597832
2	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	3.48354038
3	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.85905833
4	Other glycan degradation_Homo sapiens_hsa00511	2.84215253
5	Arginine biosynthesis_Homo sapiens_hsa00220	2.43217056
6	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.29241363
7	Steroid biosynthesis_Homo sapiens_hsa00100	2.28388075
8	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.19603075
9	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.14831457
10	Fat digestion and absorption_Homo sapiens_hsa04975	1.98774641
11	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.95789015
12	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.91492800
13	Arginine and proline metabolism_Homo sapiens_hsa00330	1.86610367
14	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.83916918
15	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.83804351
16	Histidine metabolism_Homo sapiens_hsa00340	1.76628981
17	Bile secretion_Homo sapiens_hsa04976	1.70642614
18	ABC transporters_Homo sapiens_hsa02010	1.61418678
19	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.61061711
20	Phenylalanine metabolism_Homo sapiens_hsa00360	1.54667111
21	PPAR signaling pathway_Homo sapiens_hsa03320	1.50118554
22	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.47069536
23	Thyroid hormone synthesis_Homo sapiens_hsa04918	1.45308069
24	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.37364137
25	Long-term potentiation_Homo sapiens_hsa04720	1.35793861
26	Fatty acid metabolism_Homo sapiens_hsa01212	1.33624995
27	Mineral absorption_Homo sapiens_hsa04978	1.23318642
28	Prion diseases_Homo sapiens_hsa05020	1.21854225
29	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.20369461
30	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.18819544
31	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.13698692
32	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.12326537
33	Galactose metabolism_Homo sapiens_hsa00052	1.10121838
34	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.05570576
35	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.02685124
36	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.99170228
37	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.98327209
38	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.97976441
39	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.97222193
40	Fatty acid degradation_Homo sapiens_hsa00071	0.95064320
41	Glucagon signaling pathway_Homo sapiens_hsa04922	0.92686057
42	VEGF signaling pathway_Homo sapiens_hsa04370	0.85293389
43	Renin-angiotensin system_Homo sapiens_hsa04614	0.83763419
44	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.83399000
45	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.83372581
46	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.83298959
47	ECM-receptor interaction_Homo sapiens_hsa04512	0.82085216
48	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.80927938
49	Glutamatergic synapse_Homo sapiens_hsa04724	0.80868087
50	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.80785952
51	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.78918299
52	Insulin signaling pathway_Homo sapiens_hsa04910	0.77458247
53	Lysosome_Homo sapiens_hsa04142	0.77269048
54	Sphingolipid metabolism_Homo sapiens_hsa00600	0.76441891
55	Pertussis_Homo sapiens_hsa05133	0.75170616
56	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.72795583
57	Carbon metabolism_Homo sapiens_hsa01200	0.71902475
58	Tyrosine metabolism_Homo sapiens_hsa00350	0.70916863
59	Insulin resistance_Homo sapiens_hsa04931	0.70081538
60	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.70074031
61	Nicotine addiction_Homo sapiens_hsa05033	0.69193397
62	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.69165149
63	Non-small cell lung cancer_Homo sapiens_hsa05223	0.67938450
64	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.67889592
65	AMPK signaling pathway_Homo sapiens_hsa04152	0.65299679
66	Pyruvate metabolism_Homo sapiens_hsa00620	0.65090358
67	Vibrio cholerae infection_Homo sapiens_hsa05110	0.64713272
68	Lysine degradation_Homo sapiens_hsa00310	0.63582483
69	GnRH signaling pathway_Homo sapiens_hsa04912	0.63564733
70	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.61642551
71	mTOR signaling pathway_Homo sapiens_hsa04150	0.61197583
72	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.60630883
73	GABAergic synapse_Homo sapiens_hsa04727	0.59226132
74	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.58822045
75	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.56550117
76	Sulfur relay system_Homo sapiens_hsa04122	0.54805070
77	Choline metabolism in cancer_Homo sapiens_hsa05231	0.53738381
78	Glioma_Homo sapiens_hsa05214	0.53704367
79	Amphetamine addiction_Homo sapiens_hsa05031	0.52970746
80	Estrogen signaling pathway_Homo sapiens_hsa04915	0.51561307
81	ErbB signaling pathway_Homo sapiens_hsa04012	0.48346812
82	Bladder cancer_Homo sapiens_hsa05219	0.48270644
83	Proteoglycans in cancer_Homo sapiens_hsa05205	0.47680928
84	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46405069
85	Pentose phosphate pathway_Homo sapiens_hsa00030	0.45840692
86	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.45601206
87	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.43808819
88	Wnt signaling pathway_Homo sapiens_hsa04310	0.43730228
89	Adherens junction_Homo sapiens_hsa04520	0.42920496
90	Gastric acid secretion_Homo sapiens_hsa04971	0.39154985
91	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.37636965
92	Endocytosis_Homo sapiens_hsa04144	0.37228520
93	Glycerolipid metabolism_Homo sapiens_hsa00561	0.37018850
94	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.36603812
95	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.35103897
96	Insulin secretion_Homo sapiens_hsa04911	0.33427103
97	Axon guidance_Homo sapiens_hsa04360	0.32980932
98	Endometrial cancer_Homo sapiens_hsa05213	0.31992208
99	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.31423229
100	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.30784728

SLC22A31

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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