SLC22A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)8.50401553
2cilium movement (GO:0003341)8.35309777
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.49352007
4epithelial cilium movement (GO:0003351)6.87011631
5protoporphyrinogen IX metabolic process (GO:0046501)5.61849010
6protoporphyrinogen IX biosynthetic process (GO:0006782)5.35714352
7axoneme assembly (GO:0035082)5.24842284
8tolerance induction (GO:0002507)4.66230449
9left/right pattern formation (GO:0060972)4.65782808
10response to peptidoglycan (GO:0032494)4.53286088
11positive regulation of tolerance induction (GO:0002645)4.34407505
12sodium ion export (GO:0071436)4.34086087
13cellular potassium ion homeostasis (GO:0030007)4.24387276
14negative regulation of immunoglobulin mediated immune response (GO:0002890)4.24054060
15negative regulation of B cell mediated immunity (GO:0002713)4.24054060
16detection of other organism (GO:0098543)4.21810308
17response to xenobiotic stimulus (GO:0009410)4.17423944
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.12540936
19porphyrin-containing compound biosynthetic process (GO:0006779)4.12151767
20detection of molecule of bacterial origin (GO:0032490)4.05852942
21heme biosynthetic process (GO:0006783)4.02782530
22negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.00860148
23regulation of tolerance induction (GO:0002643)3.99575373
24aminoglycoside antibiotic metabolic process (GO:0030647)3.96064394
25ventricular system development (GO:0021591)3.93944881
26detection of bacterium (GO:0016045)3.92390270
27pyrimidine-containing compound transmembrane transport (GO:0072531)3.91570658
28positive regulation of cellular amide metabolic process (GO:0034250)3.91373602
29cellular extravasation (GO:0045123)3.82049573
30negative regulation of humoral immune response (GO:0002921)3.81988427
31detection of external biotic stimulus (GO:0098581)3.81936957
32macrophage activation involved in immune response (GO:0002281)3.78996995
33regulation of cilium movement (GO:0003352)3.76442046
34negative regulation of cell killing (GO:0031342)3.72209935
35negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.72209935
36regulation of germinal center formation (GO:0002634)3.71647315
37tetrapyrrole biosynthetic process (GO:0033014)3.70990415
38lysine metabolic process (GO:0006553)3.66650980
39lysine catabolic process (GO:0006554)3.66650980
40antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.63172205
41primary alcohol catabolic process (GO:0034310)3.61071135
42gas transport (GO:0015669)3.60292436
43negative regulation of lymphocyte mediated immunity (GO:0002707)3.59955909
44regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.57054284
45left/right axis specification (GO:0070986)3.56343905
46low-density lipoprotein particle remodeling (GO:0034374)3.55806743
47antigen processing and presentation of endogenous antigen (GO:0019883)3.51012422
48oxygen transport (GO:0015671)3.49631406
49heme metabolic process (GO:0042168)3.46893605
50positive regulation of gamma-delta T cell activation (GO:0046645)3.45697894
51regulation of interleukin-6 biosynthetic process (GO:0045408)3.45042030
52urate metabolic process (GO:0046415)3.44158876
53positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.43456577
54hypotonic response (GO:0006971)3.42554500
55porphyrin-containing compound metabolic process (GO:0006778)3.42535862
56cysteine metabolic process (GO:0006534)3.42473744
57antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.34642358
58vitamin transmembrane transport (GO:0035461)3.31959277
59neutrophil mediated immunity (GO:0002446)3.31678373
60drug transmembrane transport (GO:0006855)3.30998637
61macrophage activation (GO:0042116)3.30641350
62negative regulation of interleukin-12 production (GO:0032695)3.29756703
63low-density lipoprotein particle clearance (GO:0034383)3.28561032
64detection of biotic stimulus (GO:0009595)3.28173742
65diterpenoid biosynthetic process (GO:0016102)3.27655401
66drug transport (GO:0015893)3.25437818
67production of molecular mediator involved in inflammatory response (GO:0002532)3.23451022
68microglial cell activation (GO:0001774)3.22002781
69positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.20725201
70myeloid leukocyte mediated immunity (GO:0002444)3.19859550
71hydrogen peroxide biosynthetic process (GO:0050665)3.18705219
72valine metabolic process (GO:0006573)3.15508072
73nonribosomal peptide biosynthetic process (GO:0019184)3.15185656
74killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.09856233
75disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.09856233
76regulation of interferon-beta biosynthetic process (GO:0045357)3.09742457
77glutathione biosynthetic process (GO:0006750)3.09269027
78ethanol metabolic process (GO:0006067)3.07300956
79regulation of response to osmotic stress (GO:0047484)3.05498064
80negative regulation of leukocyte mediated immunity (GO:0002704)3.04935166
81germinal center formation (GO:0002467)3.04709656
82alanine transport (GO:0032328)3.01554371
83response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.01226348
84response to host immune response (GO:0052572)3.01226348
85negative regulation of toll-like receptor signaling pathway (GO:0034122)3.00706973
86neutrophil activation (GO:0042119)3.00323492
87response to methylmercury (GO:0051597)2.99443687
88regulation of interleukin-5 production (GO:0032674)2.97106570
89neutrophil activation involved in immune response (GO:0002283)2.96991988
90very-low-density lipoprotein particle assembly (GO:0034379)2.94459132
91microtubule bundle formation (GO:0001578)2.94255819
92response to thyroid hormone (GO:0097066)2.93559488
93reactive oxygen species biosynthetic process (GO:1903409)2.92670382
94negative regulation of adaptive immune response (GO:0002820)2.92181153
95response to host (GO:0075136)2.91980440
96response to host defenses (GO:0052200)2.91980440
97response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.91980440
98regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.88404717
99negative regulation of interleukin-6 production (GO:0032715)2.87802375
100glycoside metabolic process (GO:0016137)2.87713370
101plasma lipoprotein particle organization (GO:0071827)2.84885562
102immunoglobulin mediated immune response (GO:0016064)2.84689970
103regulation of mast cell degranulation (GO:0043304)2.84579535
104regulation of gamma-delta T cell activation (GO:0046643)2.81814768
105phosphate ion transport (GO:0006817)2.80941918
106granulocyte activation (GO:0036230)2.80173412
107cellular sodium ion homeostasis (GO:0006883)2.79507263
108positive regulation of p38MAPK cascade (GO:1900745)2.79110030
109regulation of T-helper 2 cell differentiation (GO:0045628)2.78237957
110negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.76966034
111potassium ion import (GO:0010107)2.76256673
112toxin transport (GO:1901998)2.75370996
113leukocyte migration involved in inflammatory response (GO:0002523)2.75366194
114L-amino acid import (GO:0043092)2.73607300
115positive regulation of extracellular matrix organization (GO:1903055)2.72595359
116regulation of cellular amide metabolic process (GO:0034248)2.71971755
117phosphate ion transmembrane transport (GO:0035435)2.71943526
118negative regulation of erythrocyte differentiation (GO:0045647)2.71137883
119protein-lipid complex subunit organization (GO:0071825)2.69436979
120plasma lipoprotein particle assembly (GO:0034377)2.69091929
121hemoglobin metabolic process (GO:0020027)2.68140281
122regulation of toll-like receptor signaling pathway (GO:0034121)2.67397490
123regulation of myeloid leukocyte mediated immunity (GO:0002886)2.67096223
124regulation of beta-amyloid formation (GO:1902003)2.67060603
125positive regulation of monocyte chemotaxis (GO:0090026)2.66875962
126leukocyte aggregation (GO:0070486)2.65779073
127tetrapyrrole metabolic process (GO:0033013)2.63780578
128lipopolysaccharide-mediated signaling pathway (GO:0031663)2.63449480
129hydrogen peroxide catabolic process (GO:0042744)2.62412418
130negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.61372480
131regulation of leukocyte degranulation (GO:0043300)2.61059073
132superoxide anion generation (GO:0042554)2.60075297
133respiratory burst (GO:0045730)2.59102337
134fructose metabolic process (GO:0006000)2.58070025
135angiotensin maturation (GO:0002003)2.57159552
136myeloid cell activation involved in immune response (GO:0002275)2.56784668
137C4-dicarboxylate transport (GO:0015740)2.55813338
138response to type I interferon (GO:0034340)2.55359233
139regulation of mast cell activation involved in immune response (GO:0033006)2.54447170
140glutamate metabolic process (GO:0006536)2.53315312
141drug catabolic process (GO:0042737)2.52276892
142response to lead ion (GO:0010288)2.50558910
143desmosome organization (GO:0002934)2.49370885
144fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.47689521
145dicarboxylic acid biosynthetic process (GO:0043650)2.47296125
146* organic cation transport (GO:0015695)2.47121973
147positive regulation by symbiont of host defense response (GO:0052509)2.46565295
148modulation by symbiont of host defense response (GO:0052031)2.46565295
149modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.46565295
150modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.46565295
151positive regulation by organism of defense response of other organism involved in symbiotic interact2.46565295
152modulation by symbiont of host immune response (GO:0052553)2.46565295
153short-chain fatty acid metabolic process (GO:0046459)2.46386033
154protein-lipid complex assembly (GO:0065005)2.44240885
155response to phenylpropanoid (GO:0080184)2.43993393
156plasma lipoprotein particle remodeling (GO:0034369)2.43747631
157protein-lipid complex remodeling (GO:0034368)2.43747631
158macromolecular complex remodeling (GO:0034367)2.43747631
159amino acid import (GO:0043090)2.43240666
160cellular modified amino acid catabolic process (GO:0042219)2.42636635
161renal absorption (GO:0070293)2.42019485
162regulation of hypersensitivity (GO:0002883)2.41652480
163bicarbonate transport (GO:0015701)2.41509126
164negative regulation of growth of symbiont in host (GO:0044130)2.39207280
165negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.39207280
166modulation of growth of symbiont involved in interaction with host (GO:0044144)2.39207280
167regulation of growth of symbiont in host (GO:0044126)2.39207280
168positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.38692096
169disruption of cells of other organism (GO:0044364)2.38245598
170killing of cells of other organism (GO:0031640)2.38245598
171gamma-aminobutyric acid transport (GO:0015812)2.37534168
172exogenous drug catabolic process (GO:0042738)2.36064586
173iron ion import (GO:0097286)2.35991005
174alpha-linolenic acid metabolic process (GO:0036109)2.35794709
175one-carbon compound transport (GO:0019755)2.34694501
176positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.34466812
177aspartate family amino acid catabolic process (GO:0009068)2.33474349
178glycine transport (GO:0015816)2.33408599
179positive regulation of triglyceride metabolic process (GO:0090208)2.33371571
180regulation of triglyceride catabolic process (GO:0010896)2.32906026
181* carnitine metabolic process (GO:0009437)2.32094884
182tricarboxylic acid metabolic process (GO:0072350)2.31633261
183potassium ion homeostasis (GO:0055075)2.31617814
184axonemal dynein complex assembly (GO:0070286)11.9574733
185cilium or flagellum-dependent cell motility (GO:0001539)10.5689672

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.41344347
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.91027860
3GATA1_22025678_ChIP-Seq_K562_Human3.52132234
4* ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.24472612
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.99683062
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.54408676
7* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.52731250
8* RXR_22158963_ChIP-Seq_LIVER_Mouse2.46253887
9GATA1_19941826_ChIP-Seq_K562_Human2.38123232
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.33151707
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.30574594
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.27203277
13VDR_21846776_ChIP-Seq_THP-1_Human2.23152435
14SPI1_23127762_ChIP-Seq_K562_Human2.21443184
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.15838464
16* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.05999676
17* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.03396732
18* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98223288
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.96278733
20SCL_19346495_ChIP-Seq_HPC-7_Human1.94355483
21SPI1_23547873_ChIP-Seq_NB4_Human1.92848868
22RUNX1_22412390_ChIP-Seq_EML_Mouse1.91317876
23MAF_26560356_Chip-Seq_TH1_Human1.90655420
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.88375584
25FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.88189621
26IRF8_27001747_Chip-Seq_BMDM_Mouse1.84932478
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.83163038
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.82935196
29IRF8_21731497_ChIP-ChIP_J774_Mouse1.81950074
30GATA2_19941826_ChIP-Seq_K562_Human1.78384531
31KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.77893721
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.75792573
33* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70712036
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.68532968
35* GATA1_19941827_ChIP-Seq_MEL_Mouse1.67202925
36VDR_24787735_ChIP-Seq_THP-1_Human1.65641995
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.60963708
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59806217
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59758405
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.56961256
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54889182
42MYB_26560356_Chip-Seq_TH2_Human1.54690451
43FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.54464751
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.53106379
45CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.53081181
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.52010719
47STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.50601230
48CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50600439
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.50038152
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49220637
51UTX_26944678_Chip-Seq_JUKART_Human1.47564227
52TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.46868789
53RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46354236
54MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45557125
55RXR_22108803_ChIP-Seq_LS180_Human1.44716957
56IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43920536
57DROSHA_22980978_ChIP-Seq_HELA_Human1.43669146
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.42774444
59TCF7_22412390_ChIP-Seq_EML_Mouse1.40908877
60EGR1_23403033_ChIP-Seq_LIVER_Mouse1.40243271
61P63_26484246_Chip-Seq_KERATINOCYTES_Human1.39571247
62PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.39127052
63STAT1_20625510_ChIP-Seq_HELA_Human1.38412867
64IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38154608
65* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37971854
66MYB_26560356_Chip-Seq_TH1_Human1.37827466
67KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.36771447
68STAT4_19710469_ChIP-ChIP_TH1__Mouse1.36598186
69FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.35244641
70AR_21572438_ChIP-Seq_LNCaP_Human1.35072729
71ZNF263_19887448_ChIP-Seq_K562_Human1.34050639
72MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.32611296
73SOX2_27498859_Chip-Seq_STOMACH_Mouse1.32294328
74STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32287721
75SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31884332
76CDX2_20551321_ChIP-Seq_CACO-2_Human1.31119742
77CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29544961
78RACK7_27058665_Chip-Seq_MCF-7_Human1.29237128
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.28433075
80GATA3_27048872_Chip-Seq_THYMUS_Human1.26573827
81SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25867887
82ELK3_25401928_ChIP-Seq_HUVEC_Human1.25844641
83SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25355234
84SMC4_20622854_ChIP-Seq_HELA_Human1.25211218
85VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24000101
86CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23020276
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22637403
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22468631
89NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22468631
90PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22275021
91ELF1_20517297_ChIP-Seq_JURKAT_Human1.22163203
92VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.20405746
93RUNX1_27514584_Chip-Seq_MCF-7_Human1.20230712
94ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19657609
95STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19394505
96LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18641132
97NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.18120957
98BCOR_27268052_Chip-Seq_Bcells_Human1.16184831
99LXR_22292898_ChIP-Seq_THP-1_Human1.14915104
100MAF_26560356_Chip-Seq_TH2_Human1.14812005
101CJUN_26792858_Chip-Seq_BT549_Human1.14770049
102NCOR1_26117541_ChIP-Seq_K562_Human1.13403277
103GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12445583
104BCL6_27268052_Chip-Seq_Bcells_Human1.11924905
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10676663
106KDM2B_26808549_Chip-Seq_DND41_Human1.09997873
107TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09720843
108* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.08134980
109SOX2_20726797_ChIP-Seq_SW620_Human1.05974905
110CLOCK_20551151_ChIP-Seq_293T_Human1.05215737
111SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.04158295
112ERG_21242973_ChIP-ChIP_JURKAT_Human1.04047172
113CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03964907
114SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02264429
115GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02139502
116SMAD_19615063_ChIP-ChIP_OVARY_Human1.02009794
117FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00473062
118PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00387824
119STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99704444
120TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99368602
121TP63_23658742_ChIP-Seq_EP156T_Human0.99363042
122SMRT_27268052_Chip-Seq_Bcells_Human0.98486439
123* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97977904
124VDR_24763502_ChIP-Seq_THP-1_Human0.97918701
125P68_20966046_ChIP-Seq_HELA_Human0.97711658
126GATA3_26560356_Chip-Seq_TH2_Human0.96982824
127TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.96858237
128SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.96503653
129FOXO3_23340844_ChIP-Seq_DLD1_Human0.96461395
130GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94975829
131TP53_18474530_ChIP-ChIP_U2OS_Human0.94658110
132* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93168787
133ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92463376
134CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92401580
135TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91939998
136RUNX_20019798_ChIP-Seq_JUKART_Human0.90985276
137PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89608638
138GATA4_25053715_ChIP-Seq_YYC3_Human0.88222469
139HIF1A_21447827_ChIP-Seq_MCF-7_Human0.87251075
140BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.87092360
141GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85238737
142TP53_16413492_ChIP-PET_HCT116_Human0.85075743
143SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.85064612
144SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.85064612
145* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.84866579
146SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.84228341
147KDM2B_26808549_Chip-Seq_K562_Human0.83343271
148* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.83209591
149SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.82278825
150* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81897820
151BP1_19119308_ChIP-ChIP_Hs578T_Human0.79533563
152NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.79422209
153PIAS1_25552417_ChIP-Seq_VCAP_Human0.79408510
154GATA2_21666600_ChIP-Seq_HMVEC_Human0.78643811
155GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78420412
156ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.75938549
157FOXA2_19822575_ChIP-Seq_HepG2_Human0.75171940
158DNAJC2_21179169_ChIP-ChIP_NT2_Human0.74472411
159TBX20_22328084_ChIP-Seq_HEART_Mouse0.74237936
160TBX20_22080862_ChIP-Seq_HEART_Mouse0.74237936

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo4.74809160
2MP0005360_urolithiasis4.31732471
3MP0002132_abnormal_respiratory_system4.19166364
4MP0004147_increased_porphyrin_level3.82922524
5MP0002254_reproductive_system_inflammat2.95829726
6MP0002653_abnormal_ependyma_morphology2.68440762
7MP0002277_abnormal_respiratory_mucosa2.63157227
8MP0003436_decreased_susceptibility_to2.48382658
9MP0002139_abnormal_hepatobiliary_system2.46102512
10MP0004043_abnormal_pH_regulation2.33138796
11MP0003690_abnormal_glial_cell2.25179358
12MP0003646_muscle_fatigue2.21017435
13MP0006082_CNS_inflammation2.20704290
14MP0003191_abnormal_cellular_cholesterol2.09026466
15MP0002796_impaired_skin_barrier2.08822303
16MP0005332_abnormal_amino_acid2.05866418
17MP0009046_muscle_twitch2.05207079
18MP0010155_abnormal_intestine_physiology2.04008062
19MP0008260_abnormal_autophagy2.03975200
20MP0001853_heart_inflammation1.94179318
21MP0009278_abnormal_bone_marrow1.92813829
22MP0002405_respiratory_system_inflammati1.91959869
23MP0003075_altered_response_to1.83898342
24MP0004019_abnormal_vitamin_homeostasis1.80374139
25MP0003828_pulmonary_edema1.80223851
26MP0001545_abnormal_hematopoietic_system1.78266979
27MP0003186_abnormal_redox_activity1.76919526
28MP0004858_abnormal_nervous_system1.76219174
29MP0003195_calcinosis1.76058386
30MP0001765_abnormal_ion_homeostasis1.74801127
31MP0009764_decreased_sensitivity_to1.74188096
32MP0001800_abnormal_humoral_immune1.72214865
33MP0005636_abnormal_mineral_homeostasis1.71164994
34MP0002723_abnormal_immune_serum1.68068558
35MP0000465_gastrointestinal_hemorrhage1.67449531
36MP0002420_abnormal_adaptive_immunity1.67211349
37MP0002452_abnormal_antigen_presenting1.67161577
38MP0005083_abnormal_biliary_tract1.67039150
39MP0001819_abnormal_immune_cell1.65947427
40MP0002419_abnormal_innate_immunity1.65270194
41MP0000604_amyloidosis1.64829833
42MP0009643_abnormal_urine_homeostasis1.60780329
43MP0005058_abnormal_lysosome_morphology1.55036027
44MP0003329_amyloid_beta_deposits1.54019301
45MP0004883_abnormal_blood_vessel1.48748651
46MP0010329_abnormal_lipoprotein_level1.44142722
47MP0009840_abnormal_foam_cell1.42342070
48MP0000858_altered_metastatic_potential1.41866071
49MP0003806_abnormal_nucleotide_metabolis1.40593781
50MP0003183_abnormal_peptide_metabolism1.38918423
51MP0005167_abnormal_blood-brain_barrier1.38221422
52MP0005451_abnormal_body_composition1.37931832
53MP0002136_abnormal_kidney_physiology1.36887672
54MP0003172_abnormal_lysosome_physiology1.36222715
55MP0008875_abnormal_xenobiotic_pharmacok1.35951638
56MP0003303_peritoneal_inflammation1.35476670
57MP0003866_abnormal_defecation1.34016842
58MP0004885_abnormal_endolymph1.33863802
59MP0005584_abnormal_enzyme/coenzyme_acti1.33623691
60MP0001533_abnormal_skeleton_physiology1.32090425
61MP0005501_abnormal_skin_physiology1.32047667
62MP0002148_abnormal_hypersensitivity_rea1.32015337
63MP0000343_altered_response_to1.31411512
64MP0001501_abnormal_sleep_pattern1.30668568
65MP0001756_abnormal_urination1.28921501
66MP0005671_abnormal_response_to1.27359382
67MP0009785_altered_susceptibility_to1.25035063
68MP0008004_abnormal_stomach_pH1.24887059
69MP0005025_abnormal_response_to1.23287942
70MP0001835_abnormal_antigen_presentation1.22962530
71MP0002398_abnormal_bone_marrow1.20085918
72MP0005535_abnormal_body_temperature1.18646629
73MP0000716_abnormal_immune_system1.18362901
74MP0003763_abnormal_thymus_physiology1.17186359
75MP0001851_eye_inflammation1.16624710
76MP0004381_abnormal_hair_follicle1.16474017
77MP0002089_abnormal_postnatal_growth/wei1.16243757
78MP0003300_gastrointestinal_ulcer1.14033997
79MP0009333_abnormal_splenocyte_physiolog1.12762430
80MP0002722_abnormal_immune_system1.11942840
81MP0005164_abnormal_response_to1.11819644
82MP0002998_abnormal_bone_remodeling1.10340572
83MP0002138_abnormal_hepatobiliary_system1.10298344
84MP0005166_decreased_susceptibility_to1.09684724
85MP0002006_tumorigenesis1.08057482
86MP0002060_abnormal_skin_morphology1.07487263
87MP0003724_increased_susceptibility_to1.06829998
88MP0002332_abnormal_exercise_endurance1.05028111
89MP0002166_altered_tumor_susceptibility1.04638711
90MP0002971_abnormal_brown_adipose1.03287891
91MP0005464_abnormal_platelet_physiology1.03197189
92MP0001216_abnormal_epidermal_layer1.02943961
93MP0003566_abnormal_cell_adhesion1.02713683
94MP0004947_skin_inflammation1.00918608
95MP0005000_abnormal_immune_tolerance1.00834871
96MP0010771_integument_phenotype0.99803698
97MP0009765_abnormal_xenobiotic_induced0.99801176
98MP0002429_abnormal_blood_cell0.99463708
99MP0002168_other_aberrant_phenotype0.99303309
100MP0002118_abnormal_lipid_homeostasis0.99203095
101MP0008569_lethality_at_weaning0.98954516
102MP0000689_abnormal_spleen_morphology0.98554600
103MP0005310_abnormal_salivary_gland0.97718382
104MP0005319_abnormal_enzyme/_coenzyme0.97044431
105MP0002933_joint_inflammation0.94671069
106MP0000685_abnormal_immune_system0.93370090
107MP0001958_emphysema0.93118261
108MP0001790_abnormal_immune_system0.92296819
109MP0005387_immune_system_phenotype0.92296819
110MP0008469_abnormal_protein_level0.91877682
111MP0002638_abnormal_pupillary_reflex0.90772554
112MP0001663_abnormal_digestive_system0.89461963
113MP0009780_abnormal_chondrocyte_physiolo0.87984738
114MP0005076_abnormal_cell_differentiation0.87890189
115MP0005390_skeleton_phenotype0.85619502
116MP0003045_fibrosis0.85562521
117MP0002009_preneoplasia0.85456832
118MP0003638_abnormal_response/metabolism_0.84150593
119MP0000609_abnormal_liver_physiology0.83085577
120MP0005365_abnormal_bile_salt0.83075877
121MP0003453_abnormal_keratinocyte_physiol0.83047510
122MP0009931_abnormal_skin_appearance0.82839643
123MP0001845_abnormal_inflammatory_respons0.80936943
124MP0000249_abnormal_blood_vessel0.80688447
125MP0005623_abnormal_meninges_morphology0.80196760
126MP0003252_abnormal_bile_duct0.80168276
127MP0003091_abnormal_cell_migration0.80029202
128MP0005377_hearing/vestibular/ear_phenot0.79030003
129MP0003878_abnormal_ear_physiology0.79030003
130MP0004808_abnormal_hematopoietic_stem0.78674005
131MP0003633_abnormal_nervous_system0.76929376
132MP0005670_abnormal_white_adipose0.76417048
133MP0005376_homeostasis/metabolism_phenot0.76367436
134MP0000383_abnormal_hair_follicle0.76314675
135MP0004742_abnormal_vestibular_system0.75923735
136MP0003448_altered_tumor_morphology0.75561238
137MP0005174_abnormal_tail_pigmentation0.75305447
138MP0005165_increased_susceptibility_to0.75287343
139MP0009763_increased_sensitivity_to0.74369681
140MP0000920_abnormal_myelination0.74025616
141MP0004264_abnormal_extraembryonic_tissu0.73070716
142MP0001764_abnormal_homeostasis0.72708546
143MP0000678_abnormal_parathyroid_gland0.71571351
144MP0005666_abnormal_adipose_tissue0.71043633
145MP0005397_hematopoietic_system_phenotyp0.70905178
146MP0004510_myositis0.70300741
147MP0003795_abnormal_bone_structure0.70143153
148MP0001849_ear_inflammation0.69523862

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.32493407
2Abnormal respiratory motile cilium morphology (HP:0005938)9.32493407
3Dynein arm defect of respiratory motile cilia (HP:0012255)9.25987508
4Absent/shortened dynein arms (HP:0200106)9.25987508
5Abnormal respiratory motile cilium physiology (HP:0012261)9.10990719
6Abnormal ciliary motility (HP:0012262)8.99638665
7Rhinitis (HP:0012384)8.35534109
8Nasal polyposis (HP:0100582)6.74299088
9Bronchiectasis (HP:0002110)6.30840729
10Chronic bronchitis (HP:0004469)6.15186722
11Abnormality of the nasal mucosa (HP:0000433)5.77780867
12Epiphyseal dysplasia (HP:0002656)4.58663270
13Metabolic alkalosis (HP:0200114)4.37477189
14Recurrent sinusitis (HP:0011108)4.18320174
15Bronchitis (HP:0012387)3.97138310
16Poikilocytosis (HP:0004447)3.96017857
17Hypokalemic alkalosis (HP:0001949)3.88753373
18Chronic sinusitis (HP:0011109)3.81610864
19Recurrent otitis media (HP:0000403)3.59538732
20Increased circulating renin level (HP:0000848)3.54089583
21Metaphyseal cupping (HP:0003021)3.52724473
22Male infertility (HP:0003251)3.41495788
23Infertility (HP:0000789)3.41305787
24Abnormality of glutamine family amino acid metabolism (HP:0010902)3.40615409
25Chronic otitis media (HP:0000389)3.34308149
26Irregular epiphyses (HP:0010582)3.28521509
27Abnormality of proline metabolism (HP:0010907)3.25642537
28Hydroxyprolinuria (HP:0003080)3.25642537
29Cupped ribs (HP:0000887)3.23294889
30Hyperglycinuria (HP:0003108)3.13237180
31Myositis (HP:0100614)3.12681841
32Renal tubular acidosis (HP:0001947)3.09809274
33Abnormal urine output (HP:0012590)3.09351904
34Metaphyseal dysplasia (HP:0100255)3.09214202
35Eczematoid dermatitis (HP:0000976)3.09051835
36Diaphragmatic weakness (HP:0009113)3.08427205
37Abnormality of chloride homeostasis (HP:0011422)3.06898763
38Hypomagnesemia (HP:0002917)3.06537967
39Abnormal tarsal ossification (HP:0008369)3.03771244
40Polyuria (HP:0000103)2.97833574
41Abnormality of the heme biosynthetic pathway (HP:0010472)2.95029477
42Confusion (HP:0001289)2.92259669
43Delayed epiphyseal ossification (HP:0002663)2.91098531
44Hyperactive renin-angiotensin system (HP:0000841)2.79103604
45Reticulocytosis (HP:0001923)2.78548489
46Abnormality of renal excretion (HP:0011036)2.78263748
47Elevated erythrocyte sedimentation rate (HP:0003565)2.76556428
48Onycholysis (HP:0001806)2.76264801
49Recurrent abscess formation (HP:0002722)2.71503517
50Genu varum (HP:0002970)2.70557186
51Atelectasis (HP:0100750)2.67353802
52Small epiphyses (HP:0010585)2.67031498
53Acanthocytosis (HP:0001927)2.67006916
54Vacuolated lymphocytes (HP:0001922)2.66451337
55Abnormality of magnesium homeostasis (HP:0004921)2.64294144
56Recurrent bacterial skin infections (HP:0005406)2.60097024
57Orchitis (HP:0100796)2.59662188
58Gout (HP:0001997)2.57328326
59Increased cerebral lipofuscin (HP:0011813)2.53440181
60Autoimmune thrombocytopenia (HP:0001973)2.49762001
61Recurrent gram-negative bacterial infections (HP:0005420)2.49421500
62Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.48977953
63Recurrent bronchitis (HP:0002837)2.47230028
64Abnormality of macrophages (HP:0004311)2.47170640
65Hyperbilirubinemia (HP:0002904)2.45658416
66Occipital encephalocele (HP:0002085)2.45532810
67Abnormality of serine family amino acid metabolism (HP:0010894)2.44859054
68Abnormality of glycine metabolism (HP:0010895)2.44859054
69Metaphyseal irregularity (HP:0003025)2.41363145
70Retrobulbar optic neuritis (HP:0100654)2.37252999
71Optic neuritis (HP:0100653)2.37252999
72Vitreoretinal degeneration (HP:0000655)2.36943279
73Alkalosis (HP:0001948)2.35780849
74Diplopia (HP:0000651)2.34229989
75Abnormality of binocular vision (HP:0011514)2.34229989
76Abnormality of purine metabolism (HP:0004352)2.33536007
77Flat acetabular roof (HP:0003180)2.31705537
78Increased neuronal autofluorescent lipopigment (HP:0002074)2.31217145
79Abnormal drinking behavior (HP:0030082)2.28186286
80Polydipsia (HP:0001959)2.28186286
81Protuberant abdomen (HP:0001538)2.27311676
82Neonatal short-limb short stature (HP:0008921)2.26604010
83Xanthomatosis (HP:0000991)2.24222445
84Urticaria (HP:0001025)2.22928900
85Abnormality of the vertebral endplates (HP:0005106)2.22840483
86Hyperaldosteronism (HP:0000859)2.21973005
87Hypochromic microcytic anemia (HP:0004840)2.21908737
88Ketoacidosis (HP:0001993)2.21844771
89Tetany (HP:0001281)2.18024308
90Cholelithiasis (HP:0001081)2.16528638
91Absent frontal sinuses (HP:0002688)2.12509627
92Abnormality of the axillary hair (HP:0100134)2.11677749
93Abnormality of secondary sexual hair (HP:0009888)2.11677749
94Paralysis (HP:0003470)2.08351645
95Obstructive lung disease (HP:0006536)2.08326114
96Chronic obstructive pulmonary disease (HP:0006510)2.08326114
97Vascular calcification (HP:0004934)2.05144584
98Proximal tubulopathy (HP:0000114)2.04774497
99Pathologic fracture (HP:0002756)2.04687233
100Abnormal foot bone ossification (HP:0010675)2.04455070
101Flared metaphyses (HP:0003015)2.03838078
102Irregular vertebral endplates (HP:0003301)2.03752906
103Axonal loss (HP:0003447)2.00019614
104Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.3359377
105Stomatitis (HP:0010280)1.99386908
106Hypertriglyceridemia (HP:0002155)1.98925642
107Abnormal gallbladder morphology (HP:0012437)1.98615613
108Abnormality of renin-angiotensin system (HP:0000847)1.98610461
109Coxa vara (HP:0002812)1.97328270
110True hermaphroditism (HP:0010459)1.96508454
111Abnormality of reticulocytes (HP:0004312)1.96402560
112Pancreatic fibrosis (HP:0100732)1.96019533
113Renal salt wasting (HP:0000127)1.95025412
114Ketosis (HP:0001946)1.94944755
115Increased purine levels (HP:0004368)1.93625171
116Hyperuricemia (HP:0002149)1.93625171
117Ovoid vertebral bodies (HP:0003300)1.92120699
118Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.91784494
119Aplasia involving bones of the extremities (HP:0009825)1.91673630
120Aplasia involving bones of the upper limbs (HP:0009823)1.91673630
121Aplasia of the phalanges of the hand (HP:0009802)1.91673630
122Hemiplegia (HP:0002301)1.91643592
123Flat capital femoral epiphysis (HP:0003370)1.90290099
124Ileus (HP:0002595)1.89638537
125Gastrointestinal infarctions (HP:0005244)1.89456327
126Muscle fiber splitting (HP:0003555)1.87057630
127Urinary glycosaminoglycan excretion (HP:0003541)1.86800955
128Mucopolysacchariduria (HP:0008155)1.86800955
129Short femoral neck (HP:0100864)1.83169570
130Nausea (HP:0002018)1.82832001
131Recurrent skin infections (HP:0001581)1.82736203
132Mediastinal lymphadenopathy (HP:0100721)1.82198710
133Osteoarthritis (HP:0002758)1.80977533
134Abnormality of fatty-acid metabolism (HP:0004359)1.80153493
135Plantar hyperkeratosis (HP:0007556)1.79054243
136Abnormality of the lumbar spine (HP:0100712)1.77879418
137Generalized aminoaciduria (HP:0002909)1.77714967
138Gingivitis (HP:0000230)1.76975324
139Cystic liver disease (HP:0006706)1.73003898
140Recurrent fungal infections (HP:0002841)1.72342498
141Increased serum ferritin (HP:0003281)1.71660606
142Amyloidosis (HP:0011034)1.71390043
143Keratoconjunctivitis sicca (HP:0001097)1.70023363
144Microcytic anemia (HP:0001935)1.66769938
145Absent rod-and cone-mediated responses on ERG (HP:0007688)1.64183381
146Hypochromic anemia (HP:0001931)1.62470859
147Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.59977108
148Arterial thrombosis (HP:0004420)1.59804374
149Meningitis (HP:0001287)1.59206295
150Abnormal delayed hypersensitivity skin test (HP:0002963)1.56956671
151Vasculitis (HP:0002633)1.55792164
152Abnormality of iron homeostasis (HP:0011031)1.54460468
153Spontaneous hematomas (HP:0007420)1.52883145
154Polycythemia (HP:0001901)1.52081125
155Abnormality of the frontal sinuses (HP:0002687)1.51137193
156Keratoconjunctivitis (HP:0001096)1.50561530
157Nephropathy (HP:0000112)1.49970160
158Prolonged bleeding time (HP:0003010)1.49936761
159Peritonitis (HP:0002586)1.48521636
160Recurrent cutaneous fungal infections (HP:0011370)1.48001549
161Chronic mucocutaneous candidiasis (HP:0002728)1.48001549
162Bell-shaped thorax (HP:0001591)1.47194015
163Pulmonary infiltrates (HP:0002113)1.47131067
164Malnutrition (HP:0004395)1.45148512
165Pancreatic cysts (HP:0001737)1.42911546
166Episodic fever (HP:0001954)1.42408400
167Tubulointerstitial nephritis (HP:0001970)1.41239906
168Increased IgE level (HP:0003212)1.39899084
169Recurrent pneumonia (HP:0006532)1.39273780
170Interstitial pulmonary disease (HP:0006530)1.39259260
171Purpura (HP:0000979)1.39145147
172Abnormality of the distal phalanges of the toes (HP:0010182)1.39086673
173Encephalitis (HP:0002383)1.38982791
174Obstructive sleep apnea (HP:0002870)1.37966395
175Abnormality of midbrain morphology (HP:0002418)1.37728525
176Molar tooth sign on MRI (HP:0002419)1.37728525
177Pulmonary embolism (HP:0002204)1.37531016
178Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.36552146
179Chronic hepatic failure (HP:0100626)1.36179182
180Anorexia (HP:0002039)1.35457326
181Hemoptysis (HP:0002105)1.34964786
182Ventricular fibrillation (HP:0001663)1.34264790
183Epistaxis (HP:0000421)1.34132150
184Short nail (HP:0001799)1.33571712
185Gangrene (HP:0100758)1.33068370
186Chest pain (HP:0100749)1.32577725
187Distal lower limb muscle weakness (HP:0009053)1.31481139
188Hyperkalemia (HP:0002153)1.31134163

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.20052549
2MST1R4.31682163
3MAP3K32.93835540
4OXSR12.72359095
5CSK2.55090729
6RIPK42.44359163
7WNK32.35721437
8WNK42.27715239
9STK242.18166063
10MUSK2.15102035
11MAP3K142.11189287
12TRPM72.07312989
13MST42.07238851
14PBK2.03358954
15RIPK12.03109994
16ERN12.02420849
17IRAK31.89257762
18ZAP701.86318219
19TRIB31.80358015
20LMTK21.79514777
21PRPF4B1.78321340
22EPHA21.74197290
23TBK11.72941329
24TYK21.70028569
25ERBB31.64368745
26WNK11.60432382
27ABL21.52471084
28PTK2B1.52399474
29MAP3K121.47535304
30PIM21.45048993
31MAP4K11.44795839
32JAK21.44135678
33NTRK21.43176107
34PRKG21.41988627
35TAOK21.41222244
36FES1.40245491
37CAMKK21.37362557
38SIK11.34731572
39MAP3K61.33410442
40BLK1.33286797
41IKBKE1.31747330
42TNIK1.27590758
43MAP3K111.26861226
44SMG11.26203520
45MAPK121.25006346
46MAPKAPK31.24717254
47MAP2K31.23471503
48SGK31.23023301
49EPHB11.20503771
50JAK11.19283932
51SGK21.18881049
52BMX1.14452143
53TAOK11.13895742
54PTK61.12833147
55FGR1.11362768
56LRRK21.11064307
57IRAK41.08536244
58STK101.06833532
59IRAK11.05543861
60KSR21.04711551
61IKBKB1.04353807
62SGK2231.03773988
63SGK4941.03773988
64MARK21.02099380
65TNK21.00163873
66TESK20.97059666
67KIT0.96035285
68PIM10.95072144
69GRK60.93509210
70STK380.90009868
71MAP3K70.87973113
72SGK10.85903308
73MATK0.85639797
74EIF2AK20.84672941
75MAPK110.83556620
76IRAK20.83541900
77PRKCD0.82594905
78CDK60.81431809
79MARK30.77283655
80MAP3K10.75939785
81MAP3K130.74770022
82HIPK20.73266885
83MAPK40.70839296
84PRKACG0.70539326
85EIF2AK30.70338150
86CDC42BPA0.69298356
87MAP2K40.68979369
88BTK0.68923739
89SYK0.67572134
90NME10.66364234
91PRKAA20.65496150
92EPHA30.64462899
93DDR20.63623117
94CAMK1D0.63562078
95PDPK10.63487102
96MAPKAPK50.63063075
97STK40.61567571
98SIK20.61102963
99PDK10.60519083
100ABL10.60404734
101PRKD20.59739852
102TXK0.59270757
103PRKAA10.59256501
104GRK50.59036351
105ICK0.58453331
106MET0.58338181
107MAP3K20.54111760
108DYRK1A0.53292442
109TLK10.53148086
110LYN0.52639267
111TAOK30.52084980
112RET0.50818671
113LCK0.50331377
114TEC0.48849655
115GSK3A0.48319823
116RAF10.47776423
117PIK3CG0.46738424
118MAP2K60.46526138
119DAPK20.46406969
120MAP3K50.46049724
121PRKCA0.45933714
122YES10.45531335
123GRK70.44822964
124CLK10.42166132
125FYN0.42038521
126DYRK1B0.41786873
127TGFBR20.41589187
128PHKG10.41119205
129PHKG20.41119205
130NME20.40406054
131RPS6KL10.39752196
132RPS6KC10.39752196
133PRKCQ0.38237040
134CSF1R0.37504740
135CAMKK10.36906432
136MAP3K80.36825154
137FGFR30.36283909
138JAK30.35570082
139HCK0.34391333
140NEK90.33476059
141NEK60.33396343
142PRKG10.33145704
143PAK40.33130583
144RPS6KA20.32898625
145ADRBK10.32783610
146BMPR20.31362191
147MOS0.30703214
148TESK10.30474321

Predicted pathways (KEGG)

RankGene SetZ-score
1Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049644.23730630
2Nitrogen metabolism_Homo sapiens_hsa009103.22223844
3Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.41784933
4Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.02372988
5PPAR signaling pathway_Homo sapiens_hsa033202.00403523
6Fatty acid degradation_Homo sapiens_hsa000711.93244026
7Fatty acid biosynthesis_Homo sapiens_hsa000611.91951740
8Collecting duct acid secretion_Homo sapiens_hsa049661.88334093
9Bile secretion_Homo sapiens_hsa049761.84453818
10Mineral absorption_Homo sapiens_hsa049781.77830627
11Fatty acid metabolism_Homo sapiens_hsa012121.70417567
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.70202193
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.70192320
14Peroxisome_Homo sapiens_hsa041461.61362604
15Pentose and glucuronate interconversions_Homo sapiens_hsa000401.61056937
16Vitamin digestion and absorption_Homo sapiens_hsa049771.58975812
17Graft-versus-host disease_Homo sapiens_hsa053321.54481750
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.53531681
19Other glycan degradation_Homo sapiens_hsa005111.52547776
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50423170
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.50342660
22Allograft rejection_Homo sapiens_hsa053301.47445898
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46462421
24Influenza A_Homo sapiens_hsa051641.44042572
25Arginine biosynthesis_Homo sapiens_hsa002201.43282038
26Lysosome_Homo sapiens_hsa041421.43244833
27B cell receptor signaling pathway_Homo sapiens_hsa046621.43042956
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.41490524
29Carbohydrate digestion and absorption_Homo sapiens_hsa049731.40826436
30Malaria_Homo sapiens_hsa051441.40181670
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.39779282
32Acute myeloid leukemia_Homo sapiens_hsa052211.39065142
33TNF signaling pathway_Homo sapiens_hsa046681.36404149
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.36361244
35Protein digestion and absorption_Homo sapiens_hsa049741.36185861
36Measles_Homo sapiens_hsa051621.35570381
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34797744
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.34063400
39Toxoplasmosis_Homo sapiens_hsa051451.32616124
40beta-Alanine metabolism_Homo sapiens_hsa004101.32386563
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.31830520
42Staphylococcus aureus infection_Homo sapiens_hsa051501.27771550
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27638917
44Sphingolipid metabolism_Homo sapiens_hsa006001.25483694
45Autoimmune thyroid disease_Homo sapiens_hsa053201.24282303
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21801297
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.19723083
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.18651875
49NF-kappa B signaling pathway_Homo sapiens_hsa040641.16086582
50Salmonella infection_Homo sapiens_hsa051321.15947528
51Glutathione metabolism_Homo sapiens_hsa004801.15873778
52Butanoate metabolism_Homo sapiens_hsa006501.14211122
53Glycerolipid metabolism_Homo sapiens_hsa005611.13745379
54Renin-angiotensin system_Homo sapiens_hsa046141.13117789
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12922309
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11319226
57Caffeine metabolism_Homo sapiens_hsa002321.11061791
58Primary bile acid biosynthesis_Homo sapiens_hsa001201.09987821
59Adipocytokine signaling pathway_Homo sapiens_hsa049201.09900779
60Starch and sucrose metabolism_Homo sapiens_hsa005001.09644981
61Chemokine signaling pathway_Homo sapiens_hsa040621.09177470
62ABC transporters_Homo sapiens_hsa020101.08905784
63Glycosaminoglycan degradation_Homo sapiens_hsa005311.07151577
64Tryptophan metabolism_Homo sapiens_hsa003801.06800569
65Type I diabetes mellitus_Homo sapiens_hsa049401.05968064
66Non-small cell lung cancer_Homo sapiens_hsa052231.04828773
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.04551517
68Antigen processing and presentation_Homo sapiens_hsa046121.02469553
69Propanoate metabolism_Homo sapiens_hsa006401.02130293
70Phagosome_Homo sapiens_hsa041451.01232163
71Pancreatic cancer_Homo sapiens_hsa052120.99465638
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99402853
73Herpes simplex infection_Homo sapiens_hsa051680.99288515
74Leishmaniasis_Homo sapiens_hsa051400.99020529
75Tyrosine metabolism_Homo sapiens_hsa003500.97919509
76Fructose and mannose metabolism_Homo sapiens_hsa000510.95658811
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94978930
78Gastric acid secretion_Homo sapiens_hsa049710.93479088
79Sulfur metabolism_Homo sapiens_hsa009200.93306525
80Apoptosis_Homo sapiens_hsa042100.93272433
81Hepatitis B_Homo sapiens_hsa051610.92827583
82Asthma_Homo sapiens_hsa053100.90799691
83Salivary secretion_Homo sapiens_hsa049700.85946422
84Chronic myeloid leukemia_Homo sapiens_hsa052200.85907679
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84573157
86Complement and coagulation cascades_Homo sapiens_hsa046100.82235913
87T cell receptor signaling pathway_Homo sapiens_hsa046600.81928907
88Phenylalanine metabolism_Homo sapiens_hsa003600.80534572
89Thyroid hormone synthesis_Homo sapiens_hsa049180.79688099
90Histidine metabolism_Homo sapiens_hsa003400.79396365
91Pentose phosphate pathway_Homo sapiens_hsa000300.79253929
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79247111
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78203874
94Rheumatoid arthritis_Homo sapiens_hsa053230.77613115
95Viral myocarditis_Homo sapiens_hsa054160.76133948
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76123750
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75164841
98Notch signaling pathway_Homo sapiens_hsa043300.74635256
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74304887
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73364376
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72572866
102Tuberculosis_Homo sapiens_hsa051520.72559966
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.72417522
104VEGF signaling pathway_Homo sapiens_hsa043700.71898329
105Shigellosis_Homo sapiens_hsa051310.70507261
106Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69876908
107Osteoclast differentiation_Homo sapiens_hsa043800.69669520
108Regulation of autophagy_Homo sapiens_hsa041400.69412810
109Intestinal immune network for IgA production_Homo sapiens_hsa046720.66721443
110Platelet activation_Homo sapiens_hsa046110.66611090
111Endocytosis_Homo sapiens_hsa041440.66239436
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.66207389
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64058825
114Carbon metabolism_Homo sapiens_hsa012000.63892919
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.63282692
116Toll-like receptor signaling pathway_Homo sapiens_hsa046200.62247826
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61921611
118Dorso-ventral axis formation_Homo sapiens_hsa043200.61843353
119Prolactin signaling pathway_Homo sapiens_hsa049170.61842229
120Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60916157
121Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60622797
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60355712
123Synaptic vesicle cycle_Homo sapiens_hsa047210.59160803
124Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59138016
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57953457
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56982041
127Insulin resistance_Homo sapiens_hsa049310.56726113
128Pancreatic secretion_Homo sapiens_hsa049720.55706848
129NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55486746
130Viral carcinogenesis_Homo sapiens_hsa052030.54064001
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53698608
132FoxO signaling pathway_Homo sapiens_hsa040680.53443423
133Bladder cancer_Homo sapiens_hsa052190.52073196
134Renal cell carcinoma_Homo sapiens_hsa052110.51617077
135Endometrial cancer_Homo sapiens_hsa052130.50858179
136Lysine degradation_Homo sapiens_hsa003100.49185247
137Vitamin B6 metabolism_Homo sapiens_hsa007500.48947022
138Arginine and proline metabolism_Homo sapiens_hsa003300.48012285
139African trypanosomiasis_Homo sapiens_hsa051430.46979424
140Drug metabolism - other enzymes_Homo sapiens_hsa009830.46678238
141Renin secretion_Homo sapiens_hsa049240.46362860
142Long-term depression_Homo sapiens_hsa047300.46187837
143Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45767764
144ECM-receptor interaction_Homo sapiens_hsa045120.44612472
145Chemical carcinogenesis_Homo sapiens_hsa052040.44263092
146Amoebiasis_Homo sapiens_hsa051460.43812375
147Nicotine addiction_Homo sapiens_hsa050330.41958699
148Fat digestion and absorption_Homo sapiens_hsa049750.41460221
149Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41174397
150Hematopoietic cell lineage_Homo sapiens_hsa046400.40498358
151Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40157612
152Glutamatergic synapse_Homo sapiens_hsa047240.39635000
153Pyruvate metabolism_Homo sapiens_hsa006200.39472130
154Galactose metabolism_Homo sapiens_hsa000520.38543200
155Sulfur relay system_Homo sapiens_hsa041220.37342057
156Hepatitis C_Homo sapiens_hsa051600.37186254
157Pertussis_Homo sapiens_hsa051330.37000613
158Legionellosis_Homo sapiens_hsa051340.33083759
159Arachidonic acid metabolism_Homo sapiens_hsa005900.32526577
160Type II diabetes mellitus_Homo sapiens_hsa049300.31297957

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