SLC22A5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency (CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lysine catabolic process (GO:0006554)6.43810446
2lysine metabolic process (GO:0006553)6.43810446
3* drug transmembrane transport (GO:0006855)6.39328103
4urate metabolic process (GO:0046415)6.01085283
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.92730418
6L-phenylalanine catabolic process (GO:0006559)5.92730418
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.89186989
8L-phenylalanine metabolic process (GO:0006558)5.89186989
9glyoxylate metabolic process (GO:0046487)5.82542339
10* drug transport (GO:0015893)5.68747861
11cysteine metabolic process (GO:0006534)5.66781858
12aromatic amino acid family catabolic process (GO:0009074)5.55437586
13fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.50062461
14drug catabolic process (GO:0042737)5.16263471
15indole-containing compound catabolic process (GO:0042436)5.15326960
16indolalkylamine catabolic process (GO:0046218)5.15326960
17tryptophan catabolic process (GO:0006569)5.15326960
18homocysteine metabolic process (GO:0050667)5.10259139
19valine metabolic process (GO:0006573)5.02898575
20tryptophan metabolic process (GO:0006568)4.98812368
21desmosome organization (GO:0002934)4.95105006
22sulfur amino acid catabolic process (GO:0000098)4.89259762
23alpha-linolenic acid metabolic process (GO:0036109)4.80396256
24kynurenine metabolic process (GO:0070189)4.79208065
25amino-acid betaine metabolic process (GO:0006577)4.79175270
26short-chain fatty acid metabolic process (GO:0046459)4.71702230
27fatty acid beta-oxidation (GO:0006635)4.68081161
28serine family amino acid catabolic process (GO:0009071)4.62003519
29exogenous drug catabolic process (GO:0042738)4.61515926
30aspartate family amino acid catabolic process (GO:0009068)4.55299763
31carnitine shuttle (GO:0006853)4.55159641
32regulation of fatty acid oxidation (GO:0046320)4.54252150
33response to mercury ion (GO:0046689)4.42884395
34epoxygenase P450 pathway (GO:0019373)4.40759163
35fatty acid oxidation (GO:0019395)4.40024041
36branched-chain amino acid metabolic process (GO:0009081)4.38831138
37skeletal muscle adaptation (GO:0043501)4.37774976
38* organic cation transport (GO:0015695)4.37443078
39* quaternary ammonium group transport (GO:0015697)4.36538278
40bundle of His cell to Purkinje myocyte communication (GO:0086069)4.36455011
41bile acid biosynthetic process (GO:0006699)4.32989176
422-oxoglutarate metabolic process (GO:0006103)4.32713480
43lipid oxidation (GO:0034440)4.31925741
44macroautophagy (GO:0016236)4.24888580
45fatty acid catabolic process (GO:0009062)4.21625217
46intestinal epithelial cell development (GO:0060576)4.20711612
47cellular ketone body metabolic process (GO:0046950)4.20048529
48tricarboxylic acid metabolic process (GO:0072350)4.17444722
49branched-chain amino acid catabolic process (GO:0009083)4.16765261
50phosphate ion transport (GO:0006817)4.16594808
51aromatic amino acid family metabolic process (GO:0009072)4.15799725
52acetyl-CoA metabolic process (GO:0006084)4.15543136
53striated muscle atrophy (GO:0014891)4.14346308
54carnitine metabolic process (GO:0009437)4.13277949
55alpha-amino acid catabolic process (GO:1901606)4.11111586
56cellular modified amino acid catabolic process (GO:0042219)4.09478795
57triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.05612023
58monocarboxylic acid catabolic process (GO:0072329)4.01555293
59cellular amino acid catabolic process (GO:0009063)3.99978874
60positive regulation of fatty acid oxidation (GO:0046321)3.99278669
61serine family amino acid metabolic process (GO:0009069)3.99044435
62vitamin transmembrane transport (GO:0035461)3.96984340
63urea cycle (GO:0000050)3.94964087
64urea metabolic process (GO:0019627)3.94964087
65regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.94483210
66* carnitine transmembrane transport (GO:1902603)3.93601117
67regulation of fatty acid beta-oxidation (GO:0031998)3.88027756
68phosphate ion transmembrane transport (GO:0035435)3.86946531
69drug metabolic process (GO:0017144)3.85147645
70aminoglycoside antibiotic metabolic process (GO:0030647)3.84062563
71benzene-containing compound metabolic process (GO:0042537)3.83261841
72labyrinthine layer development (GO:0060711)3.83242378
73organic acid catabolic process (GO:0016054)3.82790436
74carboxylic acid catabolic process (GO:0046395)3.82790436
75glutamate metabolic process (GO:0006536)3.81984606
76NADH metabolic process (GO:0006734)3.81658599
77bile acid metabolic process (GO:0008206)3.75013637
78cellular glucuronidation (GO:0052695)3.73718376
79regulation of triglyceride catabolic process (GO:0010896)3.68424340
80nitrogen cycle metabolic process (GO:0071941)3.67007697
81intestinal absorption (GO:0050892)3.66915608
82fructose metabolic process (GO:0006000)3.65485739
83ethanol oxidation (GO:0006069)3.64749686
84indolalkylamine metabolic process (GO:0006586)3.62636918
85ketone body metabolic process (GO:1902224)3.62253343
86positive regulation of fatty acid beta-oxidation (GO:0032000)3.62174835
874-hydroxyproline metabolic process (GO:0019471)3.61324693
88flavonoid metabolic process (GO:0009812)3.58651412
89biotin metabolic process (GO:0006768)3.58381020
90* amino-acid betaine transport (GO:0015838)3.56478255
91* carnitine transport (GO:0015879)3.56478255
92glucuronate metabolic process (GO:0019585)3.55924323
93uronic acid metabolic process (GO:0006063)3.55924323
94iron ion import (GO:0097286)3.55209014
95tyrosine metabolic process (GO:0006570)3.55200553
96cellular biogenic amine catabolic process (GO:0042402)3.53449595
97amine catabolic process (GO:0009310)3.53449595
98muscle atrophy (GO:0014889)3.53289769
99regulation of cholesterol homeostasis (GO:2000188)3.53116283
100serine family amino acid biosynthetic process (GO:0009070)3.49890121
101negative regulation of sterol transport (GO:0032372)3.49174364
102negative regulation of cholesterol transport (GO:0032375)3.49174364
103protein hydroxylation (GO:0018126)3.48584998
104phospholipid homeostasis (GO:0055091)3.47364078
105vitamin D metabolic process (GO:0042359)3.40042810
106xenobiotic catabolic process (GO:0042178)3.38947692
107dicarboxylic acid biosynthetic process (GO:0043650)3.37784803
108high-density lipoprotein particle remodeling (GO:0034375)3.36971549
109heme transport (GO:0015886)3.30928671
110protein carboxylation (GO:0018214)3.29916098
111peptidyl-glutamic acid carboxylation (GO:0017187)3.29916098
112response to nitrosative stress (GO:0051409)3.27920405
113modified amino acid transport (GO:0072337)3.26429189
114small molecule catabolic process (GO:0044282)3.25921427
115fatty acid transmembrane transport (GO:1902001)3.25425682
116complement activation, alternative pathway (GO:0006957)3.24828212
117nonribosomal peptide biosynthetic process (GO:0019184)3.24372631
118very long-chain fatty acid metabolic process (GO:0000038)3.20501615
119regulation of bile acid biosynthetic process (GO:0070857)3.19758633
120response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.19050523
121response to nitric oxide (GO:0071731)3.18423437
122triglyceride homeostasis (GO:0070328)3.17722648
123acylglycerol homeostasis (GO:0055090)3.17722648
124regulation of protein activation cascade (GO:2000257)3.17033542
125regulation of cholesterol metabolic process (GO:0090181)3.11271770
126peptidyl-proline hydroxylation (GO:0019511)3.05854204
127diterpenoid biosynthetic process (GO:0016102)3.03745869
128regulation of guanylate cyclase activity (GO:0031282)3.02463515
129ventricular cardiac muscle cell action potential (GO:0086005)2.97598407
130angiotensin maturation (GO:0002003)2.82423000
131multicellular organismal water homeostasis (GO:0050891)2.81511770
132phenylpropanoid metabolic process (GO:0009698)2.79607727
133positive regulation of keratinocyte differentiation (GO:0045618)2.75997477
134regulation of keratinocyte differentiation (GO:0045616)2.75436947
135auditory receptor cell differentiation (GO:0042491)2.74668345
136hemidesmosome assembly (GO:0031581)2.74522911
137regulation of water loss via skin (GO:0033561)2.71406548
138excretion (GO:0007588)2.69096950
139bile acid and bile salt transport (GO:0015721)2.66226740
140pyrimidine-containing compound transmembrane transport (GO:0072531)2.66104887
141negative regulation of fatty acid transport (GO:2000192)2.64630936
142sulfate transport (GO:0008272)2.59815128
143creatine metabolic process (GO:0006600)2.59020841
144UDP-N-acetylglucosamine metabolic process (GO:0006047)2.58652463
145sulfur compound transport (GO:0072348)2.57770537
146keratinocyte development (GO:0003334)2.57641688
147regulation of skeletal muscle contraction (GO:0014819)2.56182938
148water homeostasis (GO:0030104)2.55272217
149steroid hormone mediated signaling pathway (GO:0043401)2.52135548
150digestion (GO:0007586)2.51475010
151relaxation of cardiac muscle (GO:0055119)2.49789409
152sulfate transmembrane transport (GO:1902358)2.48784281
153insulin-like growth factor receptor signaling pathway (GO:0048009)2.46761561
154coenzyme catabolic process (GO:0009109)2.46751368
155phenol-containing compound catabolic process (GO:0019336)2.46525862
156regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.45364269
157response to growth hormone (GO:0060416)2.45084709
158positive regulation of lipid catabolic process (GO:0050996)2.42059555
159motile cilium assembly (GO:0044458)2.40009144
160nitric oxide biosynthetic process (GO:0006809)2.39020334
161intracellular lipid transport (GO:0032365)2.38301896
162sarcomere organization (GO:0045214)2.36322823
163sphingomyelin metabolic process (GO:0006684)2.35419169
164ethanol metabolic process (GO:0006067)2.34908689
165positive regulation of epidermal cell differentiation (GO:0045606)2.34873145
166early endosome to late endosome transport (GO:0045022)2.33875906
167tight junction assembly (GO:0070830)2.31770271
168long-chain fatty acid transport (GO:0015909)2.30403061
169regulation of hippo signaling (GO:0035330)2.29536342
170cellular carbohydrate catabolic process (GO:0044275)2.29286460
171positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.28371373
172cornea development in camera-type eye (GO:0061303)2.28186716
173establishment of skin barrier (GO:0061436)2.27860604

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.10678847
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.81769911
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.05219802
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.92802484
5* LXR_22158963_ChIP-Seq_LIVER_Mouse5.31588402
6* EGR1_23403033_ChIP-Seq_LIVER_Mouse4.48941386
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.90897158
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.25432306
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.22190106
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.90286986
11ZNF217_24962896_ChIP-Seq_MCF-7_Human2.80390808
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.71319649
13AHR_22903824_ChIP-Seq_MCF-7_Human2.69878393
14* CLOCK_20551151_ChIP-Seq_293T_Human2.36359414
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.16876774
16HIF1A_21447827_ChIP-Seq_MCF-7_Human2.15248412
17GATA1_22025678_ChIP-Seq_K562_Human2.03318486
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.00832955
19TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.98837518
20SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.96730242
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94522115
22* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.89367007
23ARNT_22903824_ChIP-Seq_MCF-7_Human1.86031689
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.85943913
25ESR1_21235772_ChIP-Seq_MCF-7_Human1.79176147
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78582650
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.78340951
28SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.73891388
29SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.73891388
30FOXM1_26456572_ChIP-Seq_MCF-7_Human1.67867695
31IRF8_22096565_ChIP-ChIP_GC-B_Human1.63961826
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.62931190
33SOX2_27498859_Chip-Seq_STOMACH_Mouse1.62364831
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62046570
35FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.58201076
36FOXA2_19822575_ChIP-Seq_HepG2_Human1.53790556
37ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.52644114
38SOX9_24532713_ChIP-Seq_HFSC_Mouse1.49344317
39CTNNB1_20460455_ChIP-Seq_HCT116_Human1.48833854
40ZNF263_19887448_ChIP-Seq_K562_Human1.47966434
41CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.45376376
42KLF5_25053715_ChIP-Seq_YYC3_Human1.44473530
43ER_23166858_ChIP-Seq_MCF-7_Human1.40798195
44HNF4A_19822575_ChIP-Seq_HepG2_Human1.38203543
45* GATA4_25053715_ChIP-Seq_YYC3_Human1.37690887
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35237131
47CDX2_20551321_ChIP-Seq_CACO-2_Human1.34284332
48CHD1_26751641_Chip-Seq_LNCaP_Human1.31501045
49ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.30546555
50ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26816108
51PPAR_26484153_Chip-Seq_NCI-H1993_Human1.23688415
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23319345
53CREB1_26743006_Chip-Seq_LNCaP_Human1.21932768
54* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19794960
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19372293
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.17387642
57FOXO3_23340844_ChIP-Seq_DLD1_Human1.15995437
58TP63_22573176_ChIP-Seq_HFKS_Human1.15114704
59PKCTHETA_26484144_Chip-Seq_BREAST_Human1.12584413
60TCF4_18268006_ChIP-ChIP_LS174T_Human1.10048478
61ATF3_27146783_Chip-Seq_COLON_Human1.07598707
62TRIM28_21343339_ChIP-Seq_HEK293_Human1.05048732
63* TP63_23658742_ChIP-Seq_EP156T_Human1.04580980
64Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.02976902
65DROSHA_22980978_ChIP-Seq_HELA_Human1.02068187
66NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00432760
67SALL4_18804426_ChIP-ChIP_XEN_Mouse0.98516748
68LXR_22292898_ChIP-Seq_THP-1_Human0.97104559
69* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96837425
70* GATA6_25053715_ChIP-Seq_YYC3_Human0.96250440
71FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96180380
72STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95972207
73ESR1_20079471_ChIP-ChIP_T-47D_Human0.95303077
74TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95129427
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94630907
76* SMC4_20622854_ChIP-Seq_HELA_Human0.93731643
77EGR1_19032775_ChIP-ChIP_M12_Human0.93595991
78FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.93003635
79AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91868419
80TP63_17297297_ChIP-ChIP_HaCaT_Human0.91331042
81BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90980707
82* TBX20_22080862_ChIP-Seq_HEART_Mouse0.90824707
83* TBX20_22328084_ChIP-Seq_HEART_Mouse0.90824707
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90013829
85SOX2_20726797_ChIP-Seq_SW620_Human0.90001265
86RACK7_27058665_Chip-Seq_MCF-7_Human0.89985803
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87826334
88GATA2_21666600_ChIP-Seq_HMVEC_Human0.87823118
89ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.85788668
90P300_27058665_Chip-Seq_ZR-75-30cells_Human0.83171480
91GATA1_19941826_ChIP-Seq_K562_Human0.82922638
92* CDX2_22108803_ChIP-Seq_LS180_Human0.82428158
93* CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.82109850
94EP300_21415370_ChIP-Seq_HL-1_Mouse0.81476857
95FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.81013356
96RXR_22108803_ChIP-Seq_LS180_Human0.80806116
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.80776536
98* CJUN_26792858_Chip-Seq_BT549_Human0.80102539
99GATA2_19941826_ChIP-Seq_K562_Human0.80014085
100TDRD3_21172665_ChIP-Seq_MCF-7_Human0.79599672
101PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.79091148
102NR3C1_21868756_ChIP-Seq_MCF10A_Human0.79026061
103EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.78949665
104UBF1/2_26484160_Chip-Seq_HMECs_Human0.78621614
105STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.78095351
106* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76227896
107ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.75910053
108* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.74211689
109TP53_16413492_ChIP-PET_HCT116_Human0.74138888
110CDX2_19796622_ChIP-Seq_MESCs_Mouse0.73023367
111* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.72991737
112ELF5_23300383_ChIP-Seq_T47D_Human0.72599008
113FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.72304915
114* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.72018829
115WDR5_24793694_ChIP-Seq_LNCAP_Human0.71504799
116PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.71318047
117AR_21909140_ChIP-Seq_LNCAP_Human0.71304801
118* CEBPB_22108803_ChIP-Seq_LS180_Human0.69642012
119ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.68883583
120HOXB7_26014856_ChIP-Seq_BT474_Human0.68700024
121* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.68055889
122NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.66438974
123RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63707347
124* GATA3_24758297_ChIP-Seq_MCF-7_Human0.62627010
125* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.62521073
126SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.60998740
127KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.60734228
128NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.59742260
129NRF2_20460467_ChIP-Seq_MEFs_Mouse0.59742260
130SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.59665558
131NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.59527262
132SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.59299841
133TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.59142199
134* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.58246933
135GATA1_19941827_ChIP-Seq_MEL_Mouse0.58093393
136FOXA1_25552417_ChIP-Seq_VCAP_Human0.58062338
137RUNX1_27514584_Chip-Seq_MCF-7_Human0.57653835
138MYB_21317192_ChIP-Seq_ERMYB_Mouse0.57535812
139P63_26484246_Chip-Seq_KERATINOCYTES_Human0.57101524
140MYC_19915707_ChIP-ChIP_AK7_Human0.56890615
141RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.56231120
142PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.55866226
143SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.54837686
144SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.54791784
145* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.53415517

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.60073822
2MP0002139_abnormal_hepatobiliary_system6.96088369
3MP0005365_abnormal_bile_salt4.62695038
4MP0005085_abnormal_gallbladder_physiolo4.56194408
5MP0008875_abnormal_xenobiotic_pharmacok4.45999049
6* MP0005332_abnormal_amino_acid3.65425148
7MP0003252_abnormal_bile_duct3.42766663
8MP0004019_abnormal_vitamin_homeostasis3.38141071
9MP0009780_abnormal_chondrocyte_physiolo3.27095079
10MP0003195_calcinosis3.26767393
11MP0000383_abnormal_hair_follicle3.06891324
12MP0010678_abnormal_skin_adnexa2.88713077
13MP0004043_abnormal_pH_regulation2.86470133
14MP0002138_abnormal_hepatobiliary_system2.82783089
15MP0010329_abnormal_lipoprotein_level2.74376478
16MP0000013_abnormal_adipose_tissue2.63958498
17MP0003806_abnormal_nucleotide_metabolis2.62327882
18* MP0009643_abnormal_urine_homeostasis2.59853739
19MP0009840_abnormal_foam_cell2.52635919
20MP0001666_abnormal_nutrient_absorption2.36748229
21MP0004484_altered_response_of2.36685687
22MP0004233_abnormal_muscle_weight2.34058188
23MP0003191_abnormal_cellular_cholesterol2.09089768
24MP0001756_abnormal_urination1.89372241
25MP0002118_abnormal_lipid_homeostasis1.88073617
26MP0005670_abnormal_white_adipose1.87251497
27MP0005636_abnormal_mineral_homeostasis1.83633630
28MP0001765_abnormal_ion_homeostasis1.83032434
29MP0000427_abnormal_hair_cycle1.78951772
30MP0005584_abnormal_enzyme/coenzyme_acti1.78730242
31MP0005319_abnormal_enzyme/_coenzyme1.78727795
32MP0001873_stomach_inflammation1.78303745
33* MP0000609_abnormal_liver_physiology1.73950463
34* MP0002136_abnormal_kidney_physiology1.71201082
35MP0000003_abnormal_adipose_tissue1.69794848
36MP0005083_abnormal_biliary_tract1.67115368
37MP0003186_abnormal_redox_activity1.66469246
38MP0001664_abnormal_digestion1.54337774
39MP0002098_abnormal_vibrissa_morphology1.51334789
40MP0005409_darkened_coat_color1.50265033
41MP0000678_abnormal_parathyroid_gland1.49864415
42MP0005076_abnormal_cell_differentiation1.46323322
43MP0001764_abnormal_homeostasis1.45708657
44MP0004145_abnormal_muscle_electrophysio1.40193042
45MP0005451_abnormal_body_composition1.39712485
46MP0003183_abnormal_peptide_metabolism1.39048691
47MP0002009_preneoplasia1.39027401
48MP0000579_abnormal_nail_morphology1.34595243
49MP0003300_gastrointestinal_ulcer1.34301626
50MP0003879_abnormal_hair_cell1.33643023
51MP0004036_abnormal_muscle_relaxation1.33315799
52MP0000749_muscle_degeneration1.31729647
53MP0006138_congestive_heart_failure1.30579746
54MP0005058_abnormal_lysosome_morphology1.30508742
55MP0000747_muscle_weakness1.27269547
56MP0004087_abnormal_muscle_fiber1.25731426
57MP0005666_abnormal_adipose_tissue1.18063765
58MP0002269_muscular_atrophy1.17017436
59MP0004130_abnormal_muscle_cell1.15870234
60MP0004381_abnormal_hair_follicle1.15252596
61MP0006036_abnormal_mitochondrial_physio1.15227060
62MP0003878_abnormal_ear_physiology1.13794222
63MP0005377_hearing/vestibular/ear_phenot1.13794222
64MP0003950_abnormal_plasma_membrane1.12290876
65MP0000462_abnormal_digestive_system1.10275248
66MP0010630_abnormal_cardiac_muscle1.08003768
67MP0010234_abnormal_vibrissa_follicle1.07800515
68MP0002249_abnormal_larynx_morphology1.07316222
69MP0002254_reproductive_system_inflammat1.05443547
70MP0002876_abnormal_thyroid_physiology1.04153711
71MP0002160_abnormal_reproductive_system1.03586430
72MP0000467_abnormal_esophagus_morphology1.02179005
73MP0000538_abnormal_urinary_bladder1.01042107
74* MP0000598_abnormal_liver_morphology0.99672493
75MP0001958_emphysema0.99305949
76MP0001661_extended_life_span0.99237387
77MP0004782_abnormal_surfactant_physiolog0.98641103
78MP0003724_increased_susceptibility_to0.97077641
79MP0004084_abnormal_cardiac_muscle0.95596948
80MP0010352_gastrointestinal_tract_polyps0.95393931
81MP0000377_abnormal_hair_follicle0.95363786
82MP0002909_abnormal_adrenal_gland0.95035578
83MP0005501_abnormal_skin_physiology0.94868907
84MP0002132_abnormal_respiratory_system0.94186350
85MP0003866_abnormal_defecation0.94096207
86MP0004147_increased_porphyrin_level0.93019043
87MP0009764_decreased_sensitivity_to0.91038516
88MP0003705_abnormal_hypodermis_morpholog0.89675984
89MP0002971_abnormal_brown_adipose0.89207912
90MP0000627_abnormal_mammary_gland0.89182660
91MP0004215_abnormal_myocardial_fiber0.88254333
92MP0005084_abnormal_gallbladder_morpholo0.88245002
93MP0000604_amyloidosis0.88181007
94MP0008775_abnormal_heart_ventricle0.87701790
95MP0003045_fibrosis0.87348827
96MP0008469_abnormal_protein_level0.87191262
97MP0003690_abnormal_glial_cell0.86333093
98MP0005535_abnormal_body_temperature0.85906301
99* MP0009642_abnormal_blood_homeostasis0.85618326
100MP0000230_abnormal_systemic_arterial0.85579249
101MP0003868_abnormal_feces_composition0.85371746
102MP0003656_abnormal_erythrocyte_physiolo0.85072622
103MP0005620_abnormal_muscle_contractility0.84938073
104MP0005448_abnormal_energy_balance0.84290262
105MP0004264_abnormal_extraembryonic_tissu0.83586924
106MP0002168_other_aberrant_phenotype0.81722907
107MP0002928_abnormal_bile_duct0.81690050
108MP0001216_abnormal_epidermal_layer0.81579102
109MP0000477_abnormal_intestine_morphology0.77348160
110MP0008961_abnormal_basal_metabolism0.77046641
111MP0010368_abnormal_lymphatic_system0.76470577
112MP0002332_abnormal_exercise_endurance0.76171879
113MP0000751_myopathy0.75757933
114MP0002972_abnormal_cardiac_muscle0.73352993
115MP0009763_increased_sensitivity_to0.73268504
116MP0000750_abnormal_muscle_regeneration0.72164100
117MP0002127_abnormal_cardiovascular_syste0.71744733
118MP0001544_abnormal_cardiovascular_syste0.71081087
119MP0005385_cardiovascular_system_phenoty0.71081087
120MP0002135_abnormal_kidney_morphology0.68947515
121* MP0002078_abnormal_glucose_homeostasis0.68301002
122MP0003638_abnormal_response/metabolism_0.67351780
123MP0005375_adipose_tissue_phenotype0.66436734
124MP0005647_abnormal_sex_gland0.64832173
125MP0005376_homeostasis/metabolism_phenot0.62526982
126MP0005334_abnormal_fat_pad0.62468282
127MP0009765_abnormal_xenobiotic_induced0.62422971
128MP0005220_abnormal_exocrine_pancreas0.57729230
129MP0005165_increased_susceptibility_to0.54248076
130MP0003075_altered_response_to0.53646996
131MP0003646_muscle_fatigue0.52465816
132MP0002796_impaired_skin_barrier0.52130871
133MP0009697_abnormal_copulation0.49939178
134MP0005408_hypopigmentation0.49429872
135MP0002837_dystrophic_cardiac_calcinosis0.49409978
136MP0005395_other_phenotype0.49003201
137MP0003329_amyloid_beta_deposits0.48835144
138MP0009384_cardiac_valve_regurgitation0.48756557
139MP0005166_decreased_susceptibility_to0.48632093
140MP0005167_abnormal_blood-brain_barrier0.47858201
141MP0005330_cardiomyopathy0.47533407
142MP0004885_abnormal_endolymph0.44679929
143MP0001845_abnormal_inflammatory_respons0.43511205
144MP0002295_abnormal_pulmonary_circulatio0.42560775
145MP0005266_abnormal_metabolism0.42533812
146MP0006035_abnormal_mitochondrial_morpho0.42256774
147MP0003953_abnormal_hormone_level0.41423179
148MP0006082_CNS_inflammation0.40381997
149MP0009115_abnormal_fat_cell0.40135274
150MP0002166_altered_tumor_susceptibility0.38453921
151MP0008873_increased_physiological_sensi0.37290464
152MP0008872_abnormal_physiological_respon0.34937722
153MP0000249_abnormal_blood_vessel0.34571221
154MP0004185_abnormal_adipocyte_glucose0.34475655
155MP0005464_abnormal_platelet_physiology0.34271640

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinuria (HP:0003108)5.43762337
2Right ventricular cardiomyopathy (HP:0011663)5.34303134
3Gout (HP:0001997)5.19302965
4Abnormality of glutamine family amino acid metabolism (HP:0010902)5.18524212
5Abnormality of aromatic amino acid family metabolism (HP:0004338)4.81992441
6Abnormality of serine family amino acid metabolism (HP:0010894)4.76163249
7Abnormality of glycine metabolism (HP:0010895)4.76163249
8Increased circulating renin level (HP:0000848)4.54817141
9Hypokalemic alkalosis (HP:0001949)4.50249894
10Xanthomatosis (HP:0000991)4.47913679
11Proximal tubulopathy (HP:0000114)4.44047242
12Ketosis (HP:0001946)4.35172487
13Abnormality of fatty-acid metabolism (HP:0004359)4.28721953
14Intrahepatic cholestasis (HP:0001406)4.20240481
15Metabolic alkalosis (HP:0200114)4.15354854
16Hyperactive renin-angiotensin system (HP:0000841)4.14462322
17Abnormality of purine metabolism (HP:0004352)4.13207110
18Ketoacidosis (HP:0001993)4.10670672
19Abnormality of monocarboxylic acid metabolism (HP:0010996)4.04817150
20* Hyperammonemia (HP:0001987)4.04660911
21Increased purine levels (HP:0004368)3.87997532
22Hyperuricemia (HP:0002149)3.87997532
23Generalized aminoaciduria (HP:0002909)3.82206676
24Abnormality of aspartate family amino acid metabolism (HP:0010899)3.78096628
25Deep venous thrombosis (HP:0002625)3.73030651
26Exercise-induced myalgia (HP:0003738)3.70935611
27Hypomagnesemia (HP:0002917)3.69051760
28Alkalosis (HP:0001948)3.66787440
29Abnormality of chloride homeostasis (HP:0011422)3.65830682
30Abnormal urine output (HP:0012590)3.65762147
31Hyperglycinemia (HP:0002154)3.65711530
32Polyuria (HP:0000103)3.62004491
33Hyperkalemia (HP:0002153)3.60101309
34Decreased circulating renin level (HP:0003351)3.51341659
35Bundle branch block (HP:0011710)3.49888866
36Abnormality of nucleobase metabolism (HP:0010932)3.48165067
37Abnormality of renal excretion (HP:0011036)3.47024879
38Hyperlipoproteinemia (HP:0010980)3.36683297
39Abnormality of sulfur amino acid metabolism (HP:0004339)3.35443740
40Hydroxyprolinuria (HP:0003080)3.31816866
41Abnormality of proline metabolism (HP:0010907)3.31816866
42Hypoglycemic coma (HP:0001325)3.31039390
43Dicarboxylic aciduria (HP:0003215)3.28693824
44Abnormality of dicarboxylic acid metabolism (HP:0010995)3.28693824
45Hypobetalipoproteinemia (HP:0003563)3.23622076
46Lip pit (HP:0100267)3.23464868
47Hyporeflexia of lower limbs (HP:0002600)3.23440212
48Abnormality of urine glucose concentration (HP:0011016)3.23328557
49Glycosuria (HP:0003076)3.23328557
50Muscle fiber inclusion bodies (HP:0100299)3.10780573
51Abnormality of magnesium homeostasis (HP:0004921)3.10217489
52Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.09667365
53Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.02732803
54Delayed CNS myelination (HP:0002188)3.01632011
55Vascular calcification (HP:0004934)3.00309251
56Metabolic acidosis (HP:0001942)3.00307688
57Dysmetric saccades (HP:0000641)2.94298809
58Flat acetabular roof (HP:0003180)2.88459641
59Hypolipoproteinemia (HP:0010981)2.83558710
60Abnormality of potassium homeostasis (HP:0011042)2.83376253
61Hypoalphalipoproteinemia (HP:0003233)2.81590701
62Abnormal drinking behavior (HP:0030082)2.78757624
63Polydipsia (HP:0001959)2.78757624
64Renal salt wasting (HP:0000127)2.74375082
65Hyperaldosteronism (HP:0000859)2.70827896
66Abnormality of renin-angiotensin system (HP:0000847)2.70807947
67Malnutrition (HP:0004395)2.70745308
68Cardiovascular calcification (HP:0011915)2.68797320
69Complement deficiency (HP:0004431)2.68386888
70Epidermoid cyst (HP:0200040)2.67138583
71Fat malabsorption (HP:0002630)2.66927451
72Tetany (HP:0001281)2.62458545
73Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.62158812
74Hyponatremia (HP:0002902)2.60762272
75* Lethargy (HP:0001254)2.60531316
76Myoglobinuria (HP:0002913)2.59602795
77Prolonged partial thromboplastin time (HP:0003645)2.58864321
78* Vomiting (HP:0002013)2.53382389
79Septate vagina (HP:0001153)2.52208401
80Ileus (HP:0002595)2.50884127
81Abnormality of serum amino acid levels (HP:0003112)2.47630790
82Onycholysis (HP:0001806)2.46585795
83Nephrolithiasis (HP:0000787)2.42540820
84Renal tubular acidosis (HP:0001947)2.41702111
85Syncope (HP:0001279)2.41526265
86Abdominal distention (HP:0003270)2.40479117
87Rhabdomyolysis (HP:0003201)2.37929227
88Hyperphosphaturia (HP:0003109)2.37350097
89Nemaline bodies (HP:0003798)2.34674663
90Rickets (HP:0002748)2.32966572
91Joint hemorrhage (HP:0005261)2.29679213
92Ventricular tachycardia (HP:0004756)2.28676440
93Abnormality of the common coagulation pathway (HP:0010990)2.27700020
94Hepatocellular carcinoma (HP:0001402)2.27514876
95Cerebellar dysplasia (HP:0007033)2.26965948
96Myopathic facies (HP:0002058)2.26550581
97Nausea (HP:0002018)2.26462382
98Abnormality of alanine metabolism (HP:0010916)2.25215895
99Hyperalaninemia (HP:0003348)2.25215895
100Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25215895
101Abnormality of methionine metabolism (HP:0010901)2.24326048
102Irritability (HP:0000737)2.24137776
103Short nail (HP:0001799)2.21810375
104Pancreatitis (HP:0001733)2.18659695
105Hypercholesterolemia (HP:0003124)2.18509971
106Germ cell neoplasia (HP:0100728)2.18152325
107Abnormality of pyrimidine metabolism (HP:0004353)2.18080981
108Hyperventilation (HP:0002883)2.15737120
109Abnormal urine phosphate concentration (HP:0012599)2.14910585
110Conjugated hyperbilirubinemia (HP:0002908)2.13619993
111Enlarged kidneys (HP:0000105)2.13413976
112Adrenal overactivity (HP:0002717)2.12862545
113Heart block (HP:0012722)2.12636833
114Abnormality of the calf musculature (HP:0001430)2.11321313
115Hyperbilirubinemia (HP:0002904)2.10526867
116Vacuolated lymphocytes (HP:0001922)2.10223551
117Pigmentary retinal degeneration (HP:0001146)2.10070646
118Pili torti (HP:0003777)2.08477350
119Sensorimotor neuropathy (HP:0007141)2.08383725
120Abnormal atrioventricular conduction (HP:0005150)2.08174032
121Spastic diplegia (HP:0001264)2.07546312
122Abnormal enzyme/coenzyme activity (HP:0012379)2.06945338
123Thin bony cortex (HP:0002753)2.06531636
124EMG: myopathic abnormalities (HP:0003458)2.06270385
125Focal segmental glomerulosclerosis (HP:0000097)2.05419138
126Bulbar palsy (HP:0001283)2.04804312
127Systemic lupus erythematosus (HP:0002725)2.04540534
128Palpitations (HP:0001962)2.03936849
129Esophageal varix (HP:0002040)2.02110433
130Popliteal pterygium (HP:0009756)2.01293984
131EMG: neuropathic changes (HP:0003445)2.01289120
132Hypophosphatemia (HP:0002148)2.00377617
133Methylmalonic aciduria (HP:0012120)1.99966917
134Hypokalemia (HP:0002900)1.99861826
135Abnormality of vitamin metabolism (HP:0100508)1.99021322
136Hypercalciuria (HP:0002150)1.98398482
137Calf muscle hypertrophy (HP:0008981)1.97326185
138Myocardial infarction (HP:0001658)1.97140749
139Hypoplasia of dental enamel (HP:0006297)1.97002891
140Cerebral edema (HP:0002181)1.95794135
141Muscle hypertrophy of the lower extremities (HP:0008968)1.94686461
142Abnormality of the nasal septum (HP:0000419)1.94457886
143Progressive muscle weakness (HP:0003323)1.93936415
144Steatorrhea (HP:0002570)1.93396501
145Sparse lateral eyebrow (HP:0005338)1.92934491
146Clumsiness (HP:0002312)1.91758631
147Late onset (HP:0003584)1.91709170
148Abnormal hair laboratory examination (HP:0003328)1.90582215
149Widely patent fontanelles and sutures (HP:0004492)1.90167474
150Abnormality of alkaline phosphatase activity (HP:0004379)1.90106406
151Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.88506379
152Amelogenesis imperfecta (HP:0000705)1.86858000
153Dehydration (HP:0001944)1.85564998
154Abnormal glucose tolerance (HP:0001952)1.85120151
155Abnormality of sodium homeostasis (HP:0010931)1.84502078
156Abnormality of the intrinsic pathway (HP:0010989)1.84136975
157Abnormality of vitamin B metabolism (HP:0004340)1.83765647
158Neonatal onset (HP:0003623)1.81670239
159Abnormality of the vitamin B12 metabolism (HP:0004341)1.80074994
160Muscle fiber splitting (HP:0003555)1.79411981
161Atrioventricular block (HP:0001678)1.78444539
162Ventricular arrhythmia (HP:0004308)1.76560896
163Abnormality of small intestinal villus morphology (HP:0011472)1.75832504
164Villous atrophy (HP:0011473)1.75832504
165Mildly elevated creatine phosphokinase (HP:0008180)1.73592566
166Hypotension (HP:0002615)1.72182733
167Tubular atrophy (HP:0000092)1.70105434
168Sudden death (HP:0001699)1.69884416
169Distal lower limb muscle weakness (HP:0009053)1.69480033
170Potter facies (HP:0002009)1.69412432

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK45.51777435
2BCKDK4.93694956
3OXSR14.42088874
4WNK34.28878387
5FGFR42.98086242
6STK392.95613532
7ACVR1B2.70433293
8MAPKAPK32.56606482
9PBK2.44637388
10FRK2.43611283
11ERN12.43400408
12EEF2K2.37932578
13AKT32.36866299
14PDK32.28456457
15PDK42.28456457
16TRIB32.26336002
17OBSCN2.19004795
18SIK12.03349244
19EPHB11.95609928
20MST1R1.83712856
21PKN21.82665165
22TRPM71.77618564
23PDK21.74698744
24RPS6KB21.70216601
25RIPK11.69992309
26FGFR21.66377912
27CDK121.63044492
28PHKG21.53411305
29PHKG11.53411305
30MAP3K61.48287466
31NEK61.40184392
32EPHA21.34851711
33TYK21.32289474
34MUSK1.32032138
35KDR1.28461807
36TIE11.28456922
37PTK61.27654944
38TGFBR21.26057311
39MAP3K31.24981121
40FLT31.24922716
41MAP2K31.22749476
42RET1.20787518
43INSRR1.20052696
44STK38L1.18290833
45ICK1.17346541
46SGK4941.15770053
47SGK2231.15770053
48GRK61.11553995
49MAP2K11.09547743
50TBK11.05596654
51DMPK1.05216866
52PINK11.04654759
53MAP3K71.04501789
54SCYL21.03232128
55MAPK71.01722099
56MAPK110.96894532
57AKT20.96430093
58JAK10.96029250
59MYLK0.95997851
60FGFR30.94699617
61TAOK30.93246939
62PRKAA20.92926601
63ERBB40.91560228
64SGK30.88203629
65LRRK20.85343883
66LATS10.85114561
67GSK3A0.84133832
68PDPK10.83104255
69CAMK1G0.81007146
70RPS6KB10.79696257
71CDC42BPA0.79637340
72RPS6KA20.79178443
73JAK20.75733796
74PTK20.75600219
75MAP4K10.75326868
76MAP3K110.72545224
77MAP3K140.71367228
78WNK10.71214009
79IKBKE0.69697853
80STK240.69156191
81LMTK20.68530561
82MAPK120.68051097
83SGK20.67540246
84EPHA30.67532333
85PRKCI0.66886399
86MAP2K40.65281381
87MAP2K20.65135798
88PRKG20.63762910
89MAP2K60.60970674
90RPS6KA60.60336639
91MET0.59364628
92MAP3K10.59283964
93MAPK150.58793853
94PDK10.58685367
95ITK0.58210389
96PRKAA10.56493045
97ABL20.56108169
98RPS6KC10.53292717
99RPS6KL10.53292717
100IRAK30.53252898
101MELK0.52112869
102CHUK0.52075276
103MAP3K100.51946061
104STK380.50177606
105CAMK2D0.49196454
106TTN0.48817772
107MAPKAPK50.48179604
108CSK0.47620352
109CAMK1D0.47485947
110NME10.47385826
111PDGFRB0.47368996
112PIK3CG0.47220903
113KIT0.46497897
114NEK90.45391428
115FER0.45294108
116GRK10.45107067
117MST40.45016476
118NME20.44061240
119NEK10.41290055
120STK100.39684440
121MAP3K120.39180693
122MAPK40.36395092
123ZAP700.35969088
124JAK30.35237004
125ERBB20.34721854
126PRKD30.34323715
127CDK60.33250396
128MARK20.33004305
129PRKCZ0.32871347
130DYRK1B0.32821415
131PRKACG0.31274246
132PAK40.30920878
133TNK20.30918750
134CAMK2G0.30666824
135IGF1R0.29374274
136IRAK10.29273538
137BTK0.29232294
138PDGFRA0.26228049
139MAP3K20.25295024
140PIK3CA0.25030808
141CSF1R0.23910870
142DAPK20.23490270
143PRKCQ0.23219817
144MTOR0.23168113
145NLK0.22784019

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.35456189
2Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.10929528
3Fatty acid degradation_Homo sapiens_hsa000712.96932134
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.88608027
5Propanoate metabolism_Homo sapiens_hsa006402.88298053
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.75807389
7Butanoate metabolism_Homo sapiens_hsa006502.70249866
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.63774089
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.60510553
10Tryptophan metabolism_Homo sapiens_hsa003802.51821283
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.48536123
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.39696646
13Peroxisome_Homo sapiens_hsa041462.35637959
14Nitrogen metabolism_Homo sapiens_hsa009102.31173053
15Fatty acid metabolism_Homo sapiens_hsa012122.25370938
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.23742724
17Arginine biosynthesis_Homo sapiens_hsa002202.15936437
18PPAR signaling pathway_Homo sapiens_hsa033202.12515927
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.09733885
20beta-Alanine metabolism_Homo sapiens_hsa004102.02665944
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.94623916
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.91864833
23Pyruvate metabolism_Homo sapiens_hsa006201.88517270
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.83347965
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.79847220
26Vitamin digestion and absorption_Homo sapiens_hsa049771.69505557
27Bile secretion_Homo sapiens_hsa049761.66835131
28Sulfur metabolism_Homo sapiens_hsa009201.64722192
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.59956448
30Histidine metabolism_Homo sapiens_hsa003401.58795020
31Caffeine metabolism_Homo sapiens_hsa002321.58454406
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.56005458
33Chemical carcinogenesis_Homo sapiens_hsa052041.55991508
34Carbon metabolism_Homo sapiens_hsa012001.50828241
35Complement and coagulation cascades_Homo sapiens_hsa046101.48525904
36Starch and sucrose metabolism_Homo sapiens_hsa005001.47004640
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.44463458
38Fatty acid elongation_Homo sapiens_hsa000621.42240090
39Circadian rhythm_Homo sapiens_hsa047101.30381551
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28971127
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.27159164
42Phenylalanine metabolism_Homo sapiens_hsa003601.26671655
43Retinol metabolism_Homo sapiens_hsa008301.22063808
44Selenocompound metabolism_Homo sapiens_hsa004501.21924548
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.19219462
46Folate biosynthesis_Homo sapiens_hsa007901.18596482
47Glutathione metabolism_Homo sapiens_hsa004801.17567505
48Arginine and proline metabolism_Homo sapiens_hsa003301.13201597
49Glycerolipid metabolism_Homo sapiens_hsa005611.09197898
50Fat digestion and absorption_Homo sapiens_hsa049751.08276687
51ABC transporters_Homo sapiens_hsa020101.07851450
52Lysine degradation_Homo sapiens_hsa003101.05644018
53Biosynthesis of amino acids_Homo sapiens_hsa012301.05445302
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.98296343
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93855819
56Tight junction_Homo sapiens_hsa045300.92532101
57Ether lipid metabolism_Homo sapiens_hsa005650.89308908
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88039901
59Tyrosine metabolism_Homo sapiens_hsa003500.86882345
60Staphylococcus aureus infection_Homo sapiens_hsa051500.86823201
61Pancreatic secretion_Homo sapiens_hsa049720.80122209
62Sulfur relay system_Homo sapiens_hsa041220.78392814
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73962477
64Pentose phosphate pathway_Homo sapiens_hsa000300.73931877
65Renin secretion_Homo sapiens_hsa049240.72213466
66Inositol phosphate metabolism_Homo sapiens_hsa005620.72150770
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71860926
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71700126
69Dorso-ventral axis formation_Homo sapiens_hsa043200.71356210
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69880930
71mTOR signaling pathway_Homo sapiens_hsa041500.67204211
72Steroid biosynthesis_Homo sapiens_hsa001000.67107795
73Mineral absorption_Homo sapiens_hsa049780.66222101
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64474608
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58759010
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.57972239
77Fructose and mannose metabolism_Homo sapiens_hsa000510.57356168
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54611134
79Renin-angiotensin system_Homo sapiens_hsa046140.51408284
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50440545
81Metabolic pathways_Homo sapiens_hsa011000.50009073
82FoxO signaling pathway_Homo sapiens_hsa040680.49335373
83Other glycan degradation_Homo sapiens_hsa005110.48686302
84Fatty acid biosynthesis_Homo sapiens_hsa000610.48044813
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47003669
86Thyroid cancer_Homo sapiens_hsa052160.46356780
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.45943574
88Protein digestion and absorption_Homo sapiens_hsa049740.45027943
89* Choline metabolism in cancer_Homo sapiens_hsa052310.44794224
90Type II diabetes mellitus_Homo sapiens_hsa049300.43165109
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.42706536
92Galactose metabolism_Homo sapiens_hsa000520.42554186
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41098274
94Insulin resistance_Homo sapiens_hsa049310.39662711
95Insulin secretion_Homo sapiens_hsa049110.39148023
96Adherens junction_Homo sapiens_hsa045200.38497121
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.32663165
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30308488
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29276441
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28362208
101Vitamin B6 metabolism_Homo sapiens_hsa007500.27723881
102Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.27216219
103Endometrial cancer_Homo sapiens_hsa052130.26074386
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23787684
105Lysosome_Homo sapiens_hsa041420.23615348
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.16560443
107Collecting duct acid secretion_Homo sapiens_hsa049660.16164435
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.15926545
109Thyroid hormone synthesis_Homo sapiens_hsa049180.14491421
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.12961154
111Arachidonic acid metabolism_Homo sapiens_hsa005900.12913720
112Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.12273710
113AMPK signaling pathway_Homo sapiens_hsa041520.11771538
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.10775138
115Glucagon signaling pathway_Homo sapiens_hsa049220.05654777
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.1427217
117Insulin signaling pathway_Homo sapiens_hsa04910-0.1278490
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1267292
119Oxidative phosphorylation_Homo sapiens_hsa00190-0.1256385
120Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1223377
121Sphingolipid metabolism_Homo sapiens_hsa00600-0.0977882
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.0913911
123One carbon pool by folate_Homo sapiens_hsa00670-0.0412775
124Hepatitis C_Homo sapiens_hsa05160-0.0345519
125Linoleic acid metabolism_Homo sapiens_hsa00591-0.0058493

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